研究者詳細 - 小川　靖

論文 - 小川　靖

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A Palindromic Motif in the -2084 to -2078 Upstream Region is Essential for ABCA12 Promoter Function in Cultured Human Keratinocytes 査読有り

Yoshitaka Shimizu, Yasushi Ogawa, Kazumitsu Sugiura, Jun-ichi Takeda, Kaori Sakai-Sawada, Teruki Yanagi, Atsushi Kon, Daisuke Sawamura, Hiroshi Shimizu, Masashi Akiyama

Scientific Reports 4 巻頁： 6737 2014年10月

A palindromic motif in the -2084 to -2078 upstream region is essential for ABCA12 promoter function in cultured human keratinocytes 査読有り

Shimizu, Y., Ogawa, Y., Sugiura, K., Takeda, J.-I., Sakai-Sawada, K., Yanagi, T., Kon, A., Sawamura, D., Shimizu, H., Akiyama, M.

Scientific Reports 4 巻 2014年

Revertant Mutation Releases Confined Lethal Mutation, Opening Pandora's Box: A Novel Genetic Pathogenesis 査読有り

Ogawa, Y., Takeichi, T., Kono, M., Hamajima, N., Yamamoto, T., Sugiura, K., Akiyama, M.

PLoS Genetics 10 巻 ( 5 ) 2014年

Nuclear envelope localization of Ran-binding protein 2 and Ran-GTPase-activating protein 1 in psoriatic epidermal keratinocytes 査読有り

Yasuda, K., Sugiura, K., Takeichi, T., Ogawa, Y., Muro, Y., Akiyama, M.

Experimental Dermatology 23 巻 ( 2 ) 2014年

High survival rate of harlequin ichthyosis in Japan 査読有り

Shibata, A., Ogawa, Y., Sugiura, K., Muro, Y., Abe, R., Suzuki, T., Akiyama, M.

Journal of the American Academy of Dermatology 70 巻 ( 2 ) 2014年

Establishment of an ELISA to detect anti-glycyl-tRNA synthetase antibody (anti-EJ), a serological marker of dermatomyositis/polymyositis and interstitial lung disease 査読有り

Hane, H., Muro, Y., Watanabe, K., Ogawa, Y., Sugiura, K., Akiyama, M.

Clinica Chimica Acta 431 巻 2014年

Novel ABCA12 missense mutation p.Phe2144Ser underlies congenital ichthyosiform erythroderma 査読有り

Shimizu, Y., Sugiura, K., Aoyama, Y., Ogawa, Y., Hitomi, K., Iwatsuki, K., Akiyama, M.

Journal of Dermatology 40 巻 ( 7 ) 2013年

The majority of generalized pustular psoriasis without psoriasis vulgaris Is caused by deficiency of interleukin-36 receptor antagonist 査読有り国際誌

Sugiura, K., Takemoto, A., Yamaguchi, M., Takahashi, H., Shoda, Y., Mitsuma, T., Tsuda, K., Nishida, E., Togawa, Y., Nakajima, K., Sakakibara, A., Kawachi, S., Shimizu, M., Ito, Y., Takeichi, T., Kono, M., Ogawa, Y., Muro, Y., Ishida-Yamamoto, A., Sano, S., Matsue, H., Morita, A., Mizutani, H., Iizuka, H., Muto, M., Akiyama, M.

Journal of Investigative Dermatology 133 巻 ( 11 ) 頁： 2514 - 2521 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）

Generalized pustular psoriasis (GPP) is a rare inflammatory skin disease that can be life-threatening. Recently, it has been reported that familial GPP is caused by homozygous or compound heterozygous mutations of IL36RN. However, the majority of GPP cases are sporadic and it is controversial whether IL36RN mutations are a causative/predisposing factor for sporadic GPP. We searched for IL36RN mutations in two groups of GPP patients in the Japanese population in this study: GPP without psoriasis vulgaris (PV), and GPP with PV. Eleven cases of GPP without PV (GPP alone) and 20 cases of GPP accompanied by PV (GPP with PV) were analyzed. Surprisingly, 9 out of 11 cases of GPP alone had homozygous or compound heterozygous mutations in IL36RN. In contrast, only 2 of 20 cases of GPP with PV had compound heterozygous mutations in IL36RN. The two cases of GPP with PV who had compound heterozygous mutations in IL36RN are siblings, and both cases had PV-susceptible HLA-A*0206. We determined that GPP alone is a distinct subtype of GPP and is etiologically distinguished from GPP with PV, and that the majority of GPP alone is caused by deficiency of the interleukin-36 receptor antagonist due to IL36RN mutations.

DOI： 10.1038/jid.2013.230

Scopus

PubMed

Possible roles of barrier-to-autointegration factor 1 in regulation of keratinocyte differentiation and proliferation 査読有り

Takama, H., Sugiura, K., Ogawa, Y., Muro, Y., Akiyama, M.

Journal of Dermatological Science 71 巻 ( 2 ) 2013年

Severe chilblain lupus is associated with heterozygous missense mutations of catalytic amino acids or their adjacent mutations in the exonuclease domains of 30-repair exonuclease 1 査読有り

Sugiura, K., Takeichi, T., Kono, M., Ito, Y., Ogawa, Y., Muro, Y., Akiyama, M.

Journal of Investigative Dermatology 132 巻 ( 12 ) 頁： 2855-7 2012年

A novel IL36RN/IL1F5 homozygous nonsense mutation, p.Arg10X, in a Japanese patient with adult-onset generalized pustular psoriasis 査読有り

Sugiura, K., Takeichi, T., Kono, M., Ogawa, Y., Shimoyama, Y., Muro, Y., Akiyama, M.

British Journal of Dermatology 167 巻 ( 3 ) 2012年

Challenges to congenital genetic disorders with "RNA-targeting" chemical compounds 査読有り

Ogawa, Y., Hagiwara, M.

Pharmacology and Therapeutics 134 巻 ( 3 ) 2012年

LEDGF/DFS70 activates the MK2/IL6/STAT3 pathway in HaCaT 査読有り

Takeichi, T., Sugiura, K., Muro, Y., Ogawa, Y., Akiyama, M.

Journal of Dermatological Science 63 巻 ( 3 ) 2011年

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: Modulation of alternative pre-RNA splicing 査読有り

Debdab, M., Carreaux, F., Renault, S., Soundararajan, M., Fedorov, O., Filippakopoulos, P., Lozach, O., Babault, L., Tahtouh, T., Baratte, B., Ogawa, Y., Hagiwara, M., Eisenreich, A., Rauch, U., Knapp, S., Meijer, L., Bazureau, J.-P.

Journal of Medicinal Chemistry 54 巻 ( 12 ) 2011年

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A 査読有り

Ogawa, Y., Nonaka, Y., Goto, T., Ohnishi, E., Hiramatsu, T., Kii, I., Yoshida, M., Ikura, T., Onogi, H., Shibuya, H., Hosoya, T., Ito, N., Hagiwara, M.

Nature Communications 1 巻 ( 7 ) 2010年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NATURE PUBLISHING GROUP

Dyrk1A (dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A) is a serine/threonine kinase essential for brain development and function, and its excessive activity is considered a pathogenic factor in Down syndrome. The development of potent, selective inhibitors of Dyrk1A would help to elucidate the molecular mechanisms of normal and diseased brains, and may provide a new lead compound for molecular-targeted drug discovery. Here, we report a novel Dyrk1A inhibitor, INDY, a benzothiazole derivative showing a potent ATP-competitive inhibitory effect with IC50 and K-i values of 0.24 and 0.18 mu M, respectively. X-ray crystallography of the Dyrk1A/INDY complex revealed the binding of INDY in the ATP pocket of the enzyme. INDY effectively reversed the aberrant tau-phosphorylation and rescued the repressed NFAT (nuclear factor of activated T cell) signalling induced by Dyrk1A overexpression. Importantly, proINDY, a prodrug of INDY, effectively recovered Xenopus embryos from head malformation induced by Dyrk1A overexpression, resulting in normally developed embryos and demonstrating the utility of proINDY in vivo.

DOI： 10.1038/ncomms1090

Web of Science

Scopus

Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition 査読有り

Takeichi, T., Sugiura, K., Muro, Y., Matsumoto, K., Ogawa, Y., Futamura, K., Kaminuma, O., Hashimoto, N., Shimoyama, Y., Saito, H., Tomita, Y.

Journal of Investigative Dermatology 130 巻 ( 12 ) 2010年

Intravital imaging of IL-1Β production in skin 査読有り

Matsushima, H., Ogawa, Y., Miyazaki, T., Tanaka, H., Nishibu, A., Takashima, A.

Journal of Investigative Dermatology 130 巻 ( 6 ) 2010年

Molecular insights into the Klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members 査読有り

Goetz, R., Beenken, A., Ibrahimi, O.A., Kalinina, J., Olsen, S.K., Eliseenkova, A.V., Xu, C., Neubert, T.A., Zhang, F., Linhardt, R.J., Yu, X., White, K.E., Inagaki, T., Kliewer, S.A., Yamamoto, M., Kurosu, H., Ogawa, Y., Kuro-o, M., Lanske, B., Razzaque, M.S., Mohammadi, M.

Molecular and Cellular Biology 27 巻 ( 9 ) 2007年

βKlotho is required for metabolic activity of fibroblast growth factor 21 査読有り

Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K.P., Goetz, R., Eliseenkova, A.V., Mohammadi, M., Kuro-O, M.

Proceedings of the National Academy of Sciences of the United States of America 104 巻 ( 18 ) 2007年

Tissue-specific expression of βklotho and Fibroblast Growth Factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 査読有り

Kurosu, H., Choi, M., Ogawa, Y., Dickson, A.S., Goetz, R., Eliseenkova, A.V., Mohammadi, M., Rosenblatt, K.P., Kliewer, S.A., Kuro-O, M.

Journal of Biological Chemistry 282 巻 ( 37 ) 2007年

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