Updated on 2021/05/28

写真a

 
OGAWA, Yasushi
 
Organization
Nagoya University Hospital Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer

Degree 1

  1. 博士(医学) ( 2004.11   名古屋大学 ) 

Research Interests 4

  1. chemical biology

  2. epigenetics

  3. inflammatory keratosis

  4. dermatology

Research Areas 1

  1. Others / Others  / Dermatology

Current Research Project and SDGs 2

  1. ケミカルバイオロジー的手法による皮膚疾患の解析

  2. 皮膚疾患におけるDFS70/LEDGFの役割

Research History 3

  1. Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental UniversityResearch Assistant Professor

    2007.1 - 2010.3

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    Country:Japan

  2. University of Texas Southwestern Medical Center at DallasDepartment of PathologyPostdoctoral fellow

    2005.4 - 2007.1

  3. University of Texas Southwestern Medical Center at DallasDepartment of DermatologyPostdoctoral Fellow

    2004.4 - 2005.3

Education 1

  1. Nagoya University   Faculty of Medicine

    - 1998.3

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    Country: Japan

 

Papers 44

  1. More than keratitis, ichthyosis, and deafness: Multisystem effects of lethal GJB2 mutations

    Lilly Evelyn, Bunick Christopher G., Maley Alexander M., Zhang Shali, Spraker Mary K., Theos Amy J., Vivar Karina L., Seminario-Vidal Lucia, Bennett Adam E., Sidbury Robert, Ogawa Yasushi, Akiyama Masashi, Binder Barbara, Hadj-Rabia Smail, Morotti Raffaella A., Glusac Earl J., Choate Keith A., Richard Gabriele, Milstone Leonard M.

    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY   Vol. 80 ( 3 ) page: 617 - 625   2019.3

  2. Survey on patients with undiagnosed diseases in Japan: potential patient numbers benefiting from Japan's initiative on rare and undiagnosed diseases (IRUD).

    Adachi T, Imanishi N, Ogawa Y, Furusawa Y, Izumida Y, Izumi Y, Suematsu M

    Orphanet journal of rare diseases   Vol. 13 ( 1 ) page: 208   2018.11

  3. Pansclerotic morphea associated with hypohidrosis and anti-M3 muscarinic acetylcholine receptor antibodies. Reviewed

    Fujita-Tanaka H, Ogawa Y*, Muro Y, Ogawa-Momohara M, Asashima H, Tsuboi H, Sumida T, Akiyama M.

    Br J Dermatol   Vol. 178 ( 3 ) page: E210 - E211   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/bjd.16021

    Web of Science

  4. Biallelic Mutations in KDSR Disrupt Ceramide Synthesis and Result in a Spectrum of Keratinization Disorders Associated with Thrombocytopenia

    Takeichi Takuya, Torrelo Antonio, Lee John Y. W., Ohno Yusuke, Luisa Lozano Maria, Kihara Akio, Liu Lu, Yasuda Yuka, Ishikawa Junko, Murase Takatoshi, Belen Rodrigo Ana, Fernandez-Crehuet Pablo, Toi Yoichiro, Mellerio Jemima, Rivera Jose, Vicente Vicente, Kelsell David P., Nishimura Yutaka, Okuno Yusuke, Kojima Daiei, Ogawa Yasushi, Sugiura Kazumitsu, Simpson Michael A., McLean W. H. Irwin, Akiyama Masashi, McGrath John A.

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   Vol. 137 ( 11 ) page: 2344 - 2353   2017.11

  5. Image Gallery: Unilaterally dominant acrokeratoelastoidosis (punctate palmoplantar keratoderma type 3)

    Taki T., Ogawa Y., Sakakibara A., Kono M., Akiyama M.

    BRITISH JOURNAL OF DERMATOLOGY   Vol. 177 ( 4 ) page: E157 - E157   2017.10

  6. Pigmented macules in Waardenburg syndrome type 2 due to KITLG mutation. Reviewed

    Ogawa Y*, Kono M, Akiyama M

    Pigment Cell Melanoma Res   Vol. 30 ( 5 ) page: 501 - 504   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pcmr.12597

    Web of Science

    PubMed

  7. Image Gallery: Palmoplantar hyperkeratosis in dermatomyositis with anti-PM/Scl antibodies

    Taki T., Muro Y., Ogawa Y., Akiyama M.

    BRITISH JOURNAL OF DERMATOLOGY   Vol. 176 ( 5 ) page: E94 - E94   2017.5

  8. Epstein-Barr Virus-associated Natural Killer/T-cell Lymphoma in a Patient Receiving Therapy with Anti-Tumour Necrosis Factor and Thiopurine

    Murase Chiaki, Ogawa Yasushi, Yamamoto Azusa, Iriyama Chisako, Akiyama Masashi

    ACTA DERMATO-VENEREOLOGICA   Vol. 97 ( 2 ) page: 273 - 274   2017.2

  9. Pityriasis Rubra Pilaris Type V as an Autoinflammatory Disease by CARD14 Mutations

    Takeichi Takuya, Sugiura Kazumitsu, Nomura Toshifumi, Sakamoto Taiko, Ogawa Yasushi, Oiso Naoki, Futei Yuko, Fujisaki Aki, Koizumi Akiko, Aoyama Yumi, Nakajima Kimiko, Hatano Yutaka, Hayashi Kei, Ishida-Yamamoto Akemi, Fujiwara Sakuhei, Sano Shigetoshi, Iwatsuki Keiji, Kawada Akira, Suga Yasushi, Shimizu Hiroshi, McGrath John A., Akiyama Masashi

    JAMA DERMATOLOGY   Vol. 153 ( 1 ) page: 66 - 70   2017.1

  10. IgE-independent pathophysiology of severe atopic dermatitis demonstrated in an IgE-deficient patient. Reviewed

    Ogawa Y, Kono M, Tsujikawa M, Tsujiuchi H, Akiyama M.

    J Dermatol Sci.   Vol. 82 ( 2 ) page: 139-141   2016.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jdermsci.2016.01.008.

  11. Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis. Reviewed

    Masaki S, Kii I, Sumida Y, Kato-Sumida T, Ogawa Y, Ito N, Nakamura M, Sonamoto R, Kataoka N, Hosoya T, Hagiwara M.

    Bioorg Med Chem.   Vol. 23 ( 15 ) page: 4434-4441   2015.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmc.2015.06.018.

  12. Anti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma. Reviewed

    Muro Y, Hosono Y, Sugiura K, Ogawa Y, Mimori T, Akiyama M.

    Arthritis Res Ther.   Vol. 17 ( 1 ) page: 57   2015.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13075-015-0573-x.

  13. A Palindromic Motif in the -2084 to -2078 Upstream Region is Essential for ABCA12 Promoter Function in Cultured Human Keratinocytes Reviewed

    Yoshitaka Shimizu, Yasushi Ogawa, Kazumitsu Sugiura, Jun-ichi Takeda, Kaori Sakai-Sawada, Teruki Yanagi, Atsushi Kon, Daisuke Sawamura, Hiroshi Shimizu, Masashi Akiyama

    Scientific Reports   Vol. 4   page: 6737   2014.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  14. Revertant mutation releases confined lethal mutation, opening Pandora's box: a novel genetic pathogenesis Reviewed

    Ogawa, Y. Takeichi, T. Kono, M. Hamajima, N. Yamamoto, T. Sugiura, K. Akiyama, M.

    PLoS Genet   Vol. 10 ( 5 ) page: e1004276   2014.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  15. Establishment of an ELISA to detect anti-glycyl-tRNA synthetase antibody (anti-EJ), a serological marker of dermatomyositis/polymyositis and interstitial lung disease Reviewed

    Hane, H. Muro, Y. Watanabe, K. Ogawa, Y. Sugiura, K. Akiyama, M.

    Clin Chim Acta   Vol. 431   page: 9-14   2014.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  16. Nuclear envelope localization of Ran-binding protein 2 and Ran-GTPase-activating protein 1 in psoriatic epidermal keratinocytes Reviewed

    Yasuda, K. Sugiura, K. Takeichi, T. Ogawa, Y. Muro, Y. Akiyama, M.

    Exp Dermatol   Vol. 23 ( 2 ) page: 119-124   2014.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  17. High survival rate of harlequin ichthyosis in Japan Reviewed

    Shibata, A. Ogawa, Y. Sugiura, K. Muro, Y. Abe, R. Suzuki, T. Akiyama, M.

    J Am Acad Dermatol   Vol. 70 ( 2 ) page: 387-388   2014.2

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  18. The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist Reviewed

    Sugiura, K. Takemoto, A. Yamaguchi, M. Takahashi, H. Shoda, Y. Mitsuma, T. Tsuda, K. Nishida, E. Togawa, Y. Nakajima, K. Sakakibara, A. Kawachi, S. Shimizu, M. Ito, Y. Takeichi, T. Kono, M. Ogawa, Y. Muro, Y. Ishida-Yamamoto, A. Sano, S. Matsue, H. Morita, A. Mizutani, H. Iizuka, H. Muto, M. Akiyama, M.

    J Invest Dermatol   Vol. 133 ( 11 ) page: 2514-2521   2013.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  19. Possible roles of barrier-to-autointegration factor 1 in regulation of keratinocyte differentiation and proliferation

    Takama, H. Sugiura, K. Ogawa, Y. Muro, Y. Akiyama, M.

    J Dermatol Sci   Vol. 71 ( 2 ) page: 100-106   2013.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  20. Novel ABCA12 missense mutation p.Phe2144Ser underlies congenital ichthyosiform erythroderma Reviewed

    Shimizu, Y. Sugiura, K. Aoyama, Y. Ogawa, Y. Hitomi, K. Iwatsuki, K. Akiyama, M.

    J Dermatol Sci   Vol. 40 ( 7 ) page: 581-582   2013.7

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  21. Severe chilblain lupus is associated with heterozygous missense mutations of catalytic amino acids or their adjacent mutations in the exonuclease domains of 3'-repair exonuclease 1. Reviewed

    Sugiura, K. Takeichi, T. Kono, M. Ito, Y. Ogawa, Y. Muro, Y. Akiyama, M.

    J Invest Dermatol   Vol. 132 ( 12 ) page: 2855-7   2012.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/jid.2012.210

  22. A novel IL36RN/IL1F5 homozygous nonsense mutation, p.Arg10X, in a Japanese patient with adult-onset generalized pustular psoriasis Reviewed

    Sugiura, K. Takeichi, T. Kono, M. Ogawa, Y. Shimoyama, Y. Muro, Y. Akiyama, M. Br J Dermatol

    Br J Dermatol   Vol. 167 ( 3 ) page: 699-701   2012.9

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  23. Severe Chilblain Lupus Is Associated with Heterozygous Missense Mutations of Catalytic Amino Acids or their Adjacent Mutations in the Exonuclease Domains of 3'-Repair Exonuclease 1. Reviewed

    Sugiura K, Takeichi T, Kono M, Ito Y, Ogawa Y, Muro Y and Akiyama M

    J Invest Dermatol     page: In press   2012

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    Language:English   Publishing type:Research paper (scientific journal)  

  24. Challenges to congenital genetic disorders with "RNA-targeting" chemical compounds Invited Reviewed

    Ogawa Y and Hagiwara M.

    Pharmacol Ther   Vol. 134 ( 3 ) page: 298-305   2012

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  25. LEDGF/DFS70 activates the MK2/IL6/STAT3 pathway in HaCaT. Reviewed

    Takeichi T, Sugiura K, Muro Y, Ogawa Y, Akiyama M

    J Dermatol Sci   Vol. 63 ( 3 ) page: 203-5   2011.9

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  26. Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. Reviewed

    Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP.

    J Med Chem   Vol. 54 ( 12 ) page: 4172-86   2011.6

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    Language:English   Publishing type:Research paper (scientific journal)  

  27. Overexpression of LEDGF/DFS70 Induces IL-6 via p38 Activation in HaCaT Cells, Similar to that Seen in the Psoriatic Condition. Reviewed

    Takeichi T, Sugiura K, Muro Y, Matsumoto K, Ogawa Y, Futamura K, Kaminuma O, Hashimoto N, Shimoyama Y, Saito H, Tomita Y.

    J Invest Dermatol   Vol. 130 ( 12 ) page: 2760-7   2010.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  28. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Reviewed

    Ogawa Y, Nonaka Y, Goto T, Ohnishi E, Hiramatsu T, Kii I, Yoshida M, Ikura T, Onogi H, Shibuya H, Hosoya T, Ito N, Hagiwara M.

    Nature Communications   Vol. 1   2010.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  29. Intravital imaging of IL-1beta production in skin Reviewed

    Matsushima H, Ogawa Y, Miyazaki T, Tanaka H, Nishibu A, Takashima A.

    J Invest Dermatol.   Vol. 130 ( 6 ) page: 1571-1580   2010.6

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  30. Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. Reviewed

    Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, Kuro-o M.

    J Biol Chem.   Vol. 282 ( 37 ) page: 26687-26695   2007.9

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  31. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Reviewed

    Goetz R, Beenken A, Ibrahimi OA, Kalinina J, Olsen SK, Eliseenkova AV, Xu C, Neubert TA, Zhang F, Linhardt RJ, Yu X, White KE, Inagaki T, Kliewer SA, Yamamoto M, Kurosu H, Ogawa Y, Kuro-o M, Lanske B, Razzaque MS, Mohammadi M.

    Mol Cell Biol.   Vol. 27 ( 9 ) page: 3417-3728   2007.5

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  32. BetaKlotho is required for metabolic activity of fibroblast growth factor 21 Reviewed

    Ogawa Y, Kurosu H, Yamamoto M, Nandi A, Rosenblatt KP, Goetz R, Eliseenkova AV, Mohammadi M, Kuro-o M.

    Proc Natl Acad Sci U S A.   Vol. 104 ( 18 ) page: 7432-7437   2007.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  33. HLA-associated production of anti-DFS70/LEDGF autoantibodies and systemic autoimmune disease. Reviewed

    Muro Y, Ogawa Y, Sugiura K, Tomita Y.

    J Autoimmun.   Vol. 26 ( 4 ) page: 252-257   2006.6

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  34. Regulation of fibroblast growth factor-23 signaling by klotho.

    Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, Baum MG, Schiavi S, Hu MC, Moe OW, Kuro-o M.

    J Biol Chem.   Vol. 281 ( 10 ) page: 6120-6123   2006.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  35. Anti-p80 coilin autoantibodies react with a conserved epitope and are associated with anti-DFS70/LEDGF autoantibodies. Reviewed

    Goto N, Sugiura K, Ogawa Y, Watanabe A, Onouchi H, Tomita Y, Muro Y.

    J Autoimmun.   Vol. 26 ( 1 ) page: 42-51   2006.2

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  36. Identification of novel pharmacological activities of an antifungal agent, nystatin, to promote dendritic cell maturation. Reviewed

    Ogawa Y, Mizumoto N, Tanaka H, Matsushima H, Takashima A.

    J Invest Dermatol.   Vol. 126 ( 2 ) page: 349-353   2006.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  37. Regulation of oxidative stress by the anti-aging hormone klotho. Reviewed

    Yamamoto M, Clark JD, Pastor JV, Gurnani P, Nandi A, Kurosu H, Miyoshi M, Ogawa Y, Castrillon DH, Rosenblatt KP, Kuro-o M.

    J Biol CHem   Vol. 280 ( 45 ) page: 38029-34   2005.11

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  38. Discovery of novel immunostimulants by dendritic-cell-based functional screening. Reviewed

    Mizumoto N, Gao J, Matsushima H, Ogawa Y, Tanaka H, Takashima A.

    Blood   Vol. 106 ( 9 ) page: 3082-3089   2005.11

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  39. Autoantibodies to DFS70/LEDGF are increased in alopecia areata patients. Reviewed

    Okamoto M, Ogawa Y, Watanabe A, Sugiura K, Shimomura Y, Aoki N, Nagasaka T, Tomita Y, Muro Y.

    J Autoimmun.   Vol. 23 ( 3 ) page: 221-231   2004.11

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  40. Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal alpha-helical domain. Reviewed

    Ogawa Y, Sugiura K, Watanabe A, Kunimatsu M, Mishima M, Tomita Y, Muro Y.

    J Autoimmun   Vol. 23 ( 3 ) page: 221-231   2004.11

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  41. A case of refractory bullous pemphigoid with plasmapheresis-associated thrombopenia: efficacy of pulsed intravenous cyclophosphamide therapy. Reviewed

    Ogawa Y, Adachi A, Okamoto M, Hashimoto T, Tomita Y.

    J Dermatol.   Vol. 31 ( 8 ) page: 651-654   2004.8

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  42. The successful use of topical tacrolimus treatment for a chronic actinic dermatitis patient with complications of idiopathic leukopenia. Reviewed

    Ogawa Y, Adachi A, Tomita Y.

    J Dermatol   Vol. 30 ( 11 ) page: 805-809   2003.11

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  43. Autoantibody to thioredoxin reductase in an ovarian cancer patient. Reviewed

    Muro Y, Ogawa Y, Kato Y, Hagiwara M.

    Biochem Biophys Res Commun.   Vol. 252 ( 2 ) page: 267-271   1998.1

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  44. Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein. Reviewed

    Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M.

    J Biol Chem.   Vol. 271 ( 30 ) page: 17957-17960   1996.7

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KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. A proof of concept study of medium chain trygryceride diet based treatment for congenital ichtgyosis

    Grant number:17K10206  2017.4 - 2018.3

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

  2. Elucidation of roles of lipid mediators in the epidermis to innovate novel therapeutic strategies for keratinization disorders

    Grant number:15H04887  2015.4 - 2018.3

    AKIYAMA Masashi

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    Authorship:Coinvestigator(s) 

    In the present study, we accumulated families with inherited keratinization disorders including ichthyosis, and performed whole exome and/or whole genome sequencing using next generation sequencers to clarify genetic causes of the patients. Clinical information and data from the genetic analysis were collected as our data bank of patients with inherited keratinization disorders.
    To elucidate the interaction between epidermal lipid synthesis and metabolism, and differentiation and proliferation of the epidermal keratinocytes, we analyzed detailed epidermal lipid profiles and differentiation/proliferation statuses of the keratinocytes in our mouse models of inherited ichthyoses. We comprehensively summarized the effects of epidermal functional lipids on differentiation and proliferation of the epidermal keratinocytes. From the present results, we considered novel therapeutic manners for keratinization disorders using epidermal functional lipids and lipid mediators.

  3. Dynamic epigenetic change of keratinocytes in inflammtory skin diseases

    Grant number:26461657  2014.4 - 2018.3

    Yasushi Ogawa

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    Authorship:Principal investigator 

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    This study aimed to investigate the roles of epigenetic changes of keratinocytes in the formation of inflammatory skin lesion of psoriasis. A reverse chemical genomics-approach was adopted. Topical imiquimod-induced skin inflammation was used as a mouse model of psoriasis, and various chemical inhibitors of chromatin modifying enzymes are applied to investigate their effect on the formation of the skin lesion. As a result we newly identified a histone demethylase inhibitor that promote the formation of the lesion, and a kinase inhibitor that suppress the skin lesion.

Industrial property rights 2

  1. DYRKを阻害するベンゾチアゾール誘導体を含有する医薬組成物

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    Applicant:萩原 正敏、 澁谷 浩司、 大西 英理子、 小川 靖、細谷 孝充、 平松 俊行、 吉田 実代

    Application no:2008-190277  Date applied:2008.7

    Country of applicant:Domestic  

  2. FGF21 Upregulates Expression of GLUT-1 in a βKlotho-Dependent Manner.

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    Applicant:Kuro-o M, Ogawa Y, Kurosu H, Rosenblatt K

    Application no:U.S. Patent Number: 7,537,903 

    Date registered:2009.5 

    Country of applicant:Foreign country