Organization
Nagoya University Hospital Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer
OGAWA, Yasushi
Degree 1
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博士（医学） （ 2004.11 名古屋大学 ）
Research Interests 4
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chemical biology
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epigenetics
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inflammatory keratosis
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dermatology
Research Areas 4
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Others / Others / Dermatology
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Life Science / Connective tissue disease and allergy / リアルワールドデータ
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Humanities & Social Sciences / Sociology of science, history of science and technology / 書誌計量学
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Life Science / Dermatology
Current Research Project and SDGs 4
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免疫アレルギー疾患対策に関する研究基盤及び評価基盤の構築」
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レセプト情報を用いた免疫アレルギー疾患の臨床分析
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研究者多様性が研究開発イノベーションにもたらす効果の書誌計量学的分析
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アトピー性皮膚炎をモデルとした次世代リバーストランスレーション研究基盤構築に向けた研究
Research History 5
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Nagoya University Department of Advanced Medicine, Nagoya University Hospital Lecturer
2020.5
Country：Japan
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Japan Agency for Medical Research and Development Department of Research Promotion, Division of Rare / Intractable Disease Research Deputy Manager
2018.4 - 2020.4
Country：Japan
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Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental UniversityResearch Assistant Professor
2007.1 - 2010.3
Country：Japan
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University of Texas Southwestern Medical Center at DallasDepartment of PathologyPostdoctoral fellow
2005.4 - 2007.1
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University of Texas Southwestern Medical Center at DallasDepartment of DermatologyPostdoctoral Fellow
2004.4 - 2005.3
Education 3
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Nagoya University Graduate School of Medicine Dermatology
2000.4 - 2004.3
Country： Japan
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Nagoya University Faculty of Medicine
- 1998.3
Country： Japan
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Nagoya University School of Medicine
1992.4 - 1998.3
Country： Japan
Professional Memberships 4
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加齢皮膚医学研究会
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The Japanese Pharmacological Society
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Japanese Dermatological Association
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The Japanese Society for Investigative Dermatology
Committee Memberships 1
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日本皮膚科学会 医療戦略委員
2018.6
Awards 3
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第1回 高木賞
2017 公益財団法人マルホ・高木皮膚科学振興財団
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第16回ガルデルマ賞
2015
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加齢皮膚医学研究基金（ロート賞）
2011 加齢皮膚医学研究会
Papers 52
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Yasutsugu Akasaki, Takenori Inomata, Masao Iwagami, Jaemyoung Sung, Ken Nagino, Takeya Adachi, Hideaki Morita, Mayumi Tamari, Keigo Kainuma, Keiko Kan-o, Hiroaki Ogata, Masafumi Sakashita, Masaki Futamura, Yosuke Kurashima, Saeko Nakajima, Katsunori Masaki, Yasushi Ogawa, Sakura Sato, Akihiro Miyagawa, Akie Midorikawa-Inomata, Keiichi Fujimoto, Yuichi Okumura, Kenta Fujio, Tianxiang Huang, Kunihiko Hirosawa, Yuki Morooka, Akira Murakami, Shintaro Nakao
Clinical and Translational Allergy Vol. 14 ( 9 ) 2024.9
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Vol. 73 ( 4 ) page： 329 - 339 2024.6
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Tatsuhiro Noda, Takuya Takeichi, Kana Tanahashi, Yasushi Ogawa, So Takeuchi, Takenori Yoshikawa, Erika Toriyama, Miwa Ashida, Sumihisa Imakado, Hitoshi Tsuchihashi, Takashi Okamoto, Yusuke Okuno, Tomoo Ogi, Kazumitsu Sugiura, Akiharu Kubo, Yoshinao Muro, Yasushi Suga, Akemi Ishida-Yamamoto, Masashi Akiyama
Experimental Dermatology Vol. 33 ( 4 ) 2024.4
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[STATE-OF-THE-ART OF GLOBAL START-UP INVESTMENT FOR ALLERGY AND IMMUNOLOGY 2022].
Takeya Adachi, Motoshi Hayano, Yasunori Ito, Takenori Inomata, Yasushi Ogawa, Keigo Kainuma, Keiko Kan-O, Yosuke Kurashima, Yu Kuwabara, Masafumi Sakashita, Sakura Sato, Yasuhiro Tomita, Saeko Nakajima, Masaki Futamura, Katsunori Masaki, Mayumi Tamari, Motohiro Ebisawa, Hideaki Morita
Arerugi = [Allergy] Vol. 73 ( 3 ) page： 268 - 278 2024
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Yasutsugu Akasaki, Masao Iwagami, Jaemyoung Sung, Ken Nagino, Takeya Adachi, Hideaki Morita, Mayumi Tamari, Keigo Kainuma, Keiko Kan‐o, Hiroaki Ogata, Masafumi Sakashita, Masaki Futamura, Yosuke Kurashima, Saeko Nakajima, Katsunori Masaki, Yasushi Ogawa, Sakura Sato, Akihiro Miyagawa, Akie Midorikawa‐Inomata, Keiichi Fujimoto, Yuichi Okumura, Kenta Fujio, Tianxiang Huang, Kunihiko Hirosawa, Yuki Morooka, Shintaro Nakao, Akira Murakami, Hiroyuki Kobayashi, Takenori Inomata
Allergy 2023.11
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A case of advanced diffuse large B-cell lymphoma diagnosed from widespread superficial mycosis of the skin Invited Reviewed
Yuika Suzuki, Chiaki Murase, Yoko Ushijima, Yuriko Hanai, Yasushi Ogawa, Takanori Toyama, Masashi Akiyama
Journal of the European Academy of Dermatology and Venereology : JEADV 2023
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Research impact analysis of international funding agencies in the realm of allergy and immunology Reviewed
Takeya Adachi, Yasushi Ogawa, Tamami Fukushi, Kei Ito, Amane Koizumi, Masashi Shirabe, Masako Toriya, Jun Hirako, Takenori Inomata, Katsunori Masaki, Ryohei Sasano, Sakura Sato, Keigo Kainuma, Masaki Futamura, Keiko Kan-O , Yosuke Kurashima, Saeko Nakajima, Masafumi Sakashita, Hideaki Morita, Aikichi Iwamoto, Sankei Nishima, Mayumi Tamari, Hajime Iizuka
Allergy 2022.5
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Evaluation of adrenaline auto-injector prescription profiles: A population-based, retrospective cohort study within the National Insurance Claims Database of Japan Reviewed
Sakura Sato, Keigo Kainuma, Tatsuya Noda, Motohiro Ebisawa, Masaki Futamura, Tomoaki Imamura, Akihiro Miyagawa, Saeko Nakajima, Yasushi Ogawa, Takenori Inomata, Keiko Kan-O, Yosuke Kurashima, Katsunori Masaki, Tomoya Myojin, Yuichi Nishioka, Masafumi Sakashita, Mayumi Tamari, Hideaki Morita, Takeya Adachi
2022
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More than keratitis, ichthyosis, and deafness: Multisystem effects of lethal GJB2 mutations Reviewed
Lilly, E., Bunick, C.G., Maley, A.M., Zhang, S., Spraker, M.K., Theos, A.J., Vivar, K.L., Seminario-Vidal, L., Bennett, A.E., Sidbury, R., Ogawa, Y., Akiyama, M., Binder, B., Hadj-Rabia, S., Morotti, R.A., Glusac, E.J., Choate, K.A., Richard, G., Milstone, L.M.
Journal of the American Academy of Dermatology Vol. 80 ( 3 ) page： 617 - 625 2019
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Adachi, T., Imanishi, N., Ogawa, Y., Furusawa, Y., Izumida, Y., Izumi, Y., Suematsu, M.
Orphanet Journal of Rare Diseases Vol. 13 ( 1 ) page： 208 2018
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Pigmented macules in Waardenburg syndrome type 2 due to KITLG mutation Reviewed
Ogawa, Y., Kono, M., Akiyama, M.
Pigment Cell and Melanoma Research Vol. 30 ( 5 ) page： 501 - 504 2017
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Taki, T., Ogawa, Y., Sakakibara, A., Kono, M., Akiyama, M.
British Journal of Dermatology Vol. 177 ( 4 ) page： E157 - E157 2017
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Murase, C., Ogawa, Y., Yamamoto, A., Iriyama, C., Akiyama, M.
Acta Dermato-Venereologica Vol. 97 ( 2 ) page： 273 - 274 2017
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Takeichi, T., Torrelo, A., Lee, J.Y.W., Ohno, Y., Lozano, M.L., Kihara, A., Liu, L., Yasuda, Y., Ishikawa, J., Murase, T., Rodrigo, A.B., Fernández-Crehuet, P., Toi, Y., Mellerio, J., Rivera, J., Vicente, V., Kelsell, D.P., Nishimura, Y., Okuno, Y., Kojima, D., Ogawa, Y., Sugiura, K., Simpson, M.A., McLean, W.H.I., Akiyama, M., McGrath, J.A.
Journal of Investigative Dermatology Vol. 137 ( 11 ) page： 2344 - 2353 2017
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抗PM/Scl抗体陽性皮膚筋炎の3例
滝 奉樹, 室 慶直, 小川 靖, 杉浦 一充, 秋山 真志
日本皮膚科学会雑誌 Vol. 126 ( 1 ) page： 33 - 33 2016.1
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IgE-independent pathophysiology of severe atopic dermatitis demonstrated in an IgE-deficient patient Reviewed
Ogawa, Y., Kono, M., Tsujikawa, M., Tsujiuchi, H., Akiyama, M.
Journal of Dermatological Science Vol. 82 ( 2 ) 2016
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Unilateral generalized linear porokeratosis with nail dystrophy Reviewed
Kono, M., Yokoyama, N., Ogawa, Y., Takama, H., Sugiura, K., Akiyama, M.
Journal of Dermatology Vol. 43 ( 3 ) 2016
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Non-infectious panniculitis during hydroxyurea therapy in a patient with myeloproliferative disease Reviewed
Ogawa, Y., Akiyama, M.
Acta Dermato-Venereologica Vol. 96 ( 4 ) 2016
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Anti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma. Reviewed
Muro Y, Hosono Y, Sugiura K, Ogawa Y, Mimori T, Akiyama M.
Arthritis Res Ther. Vol. 17 ( 1 ) page： 57 2015.5
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Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis Reviewed
Masaki, S., Kii, I., Sumida, Y., Kato-Sumida, T., Ogawa, Y., Ito, N., Nakamura, M., Sonamoto, R., Kataoka, N., Hosoya, T., Hagiwara, M.
Bioorganic and Medicinal Chemistry Vol. 23 ( 15 ) page： 4434 - 4441 2015
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A Palindromic Motif in the -2084 to -2078 Upstream Region is Essential for ABCA12 Promoter Function in Cultured Human Keratinocytes Reviewed
Yoshitaka Shimizu, Yasushi Ogawa, Kazumitsu Sugiura, Jun-ichi Takeda, Kaori Sakai-Sawada, Teruki Yanagi, Atsushi Kon, Daisuke Sawamura, Hiroshi Shimizu, Masashi Akiyama
Scientific Reports Vol. 4 page： 6737 2014.10
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Shimizu, Y., Ogawa, Y., Sugiura, K., Takeda, J.-I., Sakai-Sawada, K., Yanagi, T., Kon, A., Sawamura, D., Shimizu, H., Akiyama, M.
Scientific Reports Vol. 4 2014
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Ogawa, Y., Takeichi, T., Kono, M., Hamajima, N., Yamamoto, T., Sugiura, K., Akiyama, M.
PLoS Genetics Vol. 10 ( 5 ) 2014
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Yasuda, K., Sugiura, K., Takeichi, T., Ogawa, Y., Muro, Y., Akiyama, M.
Experimental Dermatology Vol. 23 ( 2 ) 2014
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High survival rate of harlequin ichthyosis in Japan Reviewed
Shibata, A., Ogawa, Y., Sugiura, K., Muro, Y., Abe, R., Suzuki, T., Akiyama, M.
Journal of the American Academy of Dermatology Vol. 70 ( 2 ) 2014
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Hane, H., Muro, Y., Watanabe, K., Ogawa, Y., Sugiura, K., Akiyama, M.
Clinica Chimica Acta Vol. 431 2014
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Novel ABCA12 missense mutation p.Phe2144Ser underlies congenital ichthyosiform erythroderma Reviewed
Shimizu, Y., Sugiura, K., Aoyama, Y., Ogawa, Y., Hitomi, K., Iwatsuki, K., Akiyama, M.
Journal of Dermatology Vol. 40 ( 7 ) 2013
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The majority of generalized pustular psoriasis without psoriasis vulgaris Is caused by deficiency of interleukin-36 receptor antagonist Reviewed International journal
Sugiura, K., Takemoto, A., Yamaguchi, M., Takahashi, H., Shoda, Y., Mitsuma, T., Tsuda, K., Nishida, E., Togawa, Y., Nakajima, K., Sakakibara, A., Kawachi, S., Shimizu, M., Ito, Y., Takeichi, T., Kono, M., Ogawa, Y., Muro, Y., Ishida-Yamamoto, A., Sano, S., Matsue, H., Morita, A., Mizutani, H., Iizuka, H., Muto, M., Akiyama, M.
Journal of Investigative Dermatology Vol. 133 ( 11 ) page： 2514 - 2521 2013
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Takama, H., Sugiura, K., Ogawa, Y., Muro, Y., Akiyama, M.
Journal of Dermatological Science Vol. 71 ( 2 ) 2013
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Sugiura, K., Takeichi, T., Kono, M., Ito, Y., Ogawa, Y., Muro, Y., Akiyama, M.
Journal of Investigative Dermatology Vol. 132 ( 12 ) page： 2855-7 2012
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Sugiura, K., Takeichi, T., Kono, M., Ogawa, Y., Shimoyama, Y., Muro, Y., Akiyama, M.
British Journal of Dermatology Vol. 167 ( 3 ) 2012
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Challenges to congenital genetic disorders with "RNA-targeting" chemical compounds Reviewed
Ogawa, Y., Hagiwara, M.
Pharmacology and Therapeutics Vol. 134 ( 3 ) 2012
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LEDGF/DFS70 activates the MK2/IL6/STAT3 pathway in HaCaT Reviewed
Takeichi, T., Sugiura, K., Muro, Y., Ogawa, Y., Akiyama, M.
Journal of Dermatological Science Vol. 63 ( 3 ) 2011
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Debdab, M., Carreaux, F., Renault, S., Soundararajan, M., Fedorov, O., Filippakopoulos, P., Lozach, O., Babault, L., Tahtouh, T., Baratte, B., Ogawa, Y., Hagiwara, M., Eisenreich, A., Rauch, U., Knapp, S., Meijer, L., Bazureau, J.-P.
Journal of Medicinal Chemistry Vol. 54 ( 12 ) 2011
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Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A Reviewed
Ogawa, Y., Nonaka, Y., Goto, T., Ohnishi, E., Hiramatsu, T., Kii, I., Yoshida, M., Ikura, T., Onogi, H., Shibuya, H., Hosoya, T., Ito, N., Hagiwara, M.
Nature Communications Vol. 1 ( 7 ) 2010
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Takeichi, T., Sugiura, K., Muro, Y., Matsumoto, K., Ogawa, Y., Futamura, K., Kaminuma, O., Hashimoto, N., Shimoyama, Y., Saito, H., Tomita, Y.
Journal of Investigative Dermatology Vol. 130 ( 12 ) 2010
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Intravital imaging of IL-1Β production in skin Reviewed
Matsushima, H., Ogawa, Y., Miyazaki, T., Tanaka, H., Nishibu, A., Takashima, A.
Journal of Investigative Dermatology Vol. 130 ( 6 ) 2010
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Goetz, R., Beenken, A., Ibrahimi, O.A., Kalinina, J., Olsen, S.K., Eliseenkova, A.V., Xu, C., Neubert, T.A., Zhang, F., Linhardt, R.J., Yu, X., White, K.E., Inagaki, T., Kliewer, S.A., Yamamoto, M., Kurosu, H., Ogawa, Y., Kuro-o, M., Lanske, B., Razzaque, M.S., Mohammadi, M.
Molecular and Cellular Biology Vol. 27 ( 9 ) 2007
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βKlotho is required for metabolic activity of fibroblast growth factor 21 Reviewed
Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K.P., Goetz, R., Eliseenkova, A.V., Mohammadi, M., Kuro-O, M.
Proceedings of the National Academy of Sciences of the United States of America Vol. 104 ( 18 ) 2007
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Kurosu, H., Choi, M., Ogawa, Y., Dickson, A.S., Goetz, R., Eliseenkova, A.V., Mohammadi, M., Rosenblatt, K.P., Kliewer, S.A., Kuro-O, M.
Journal of Biological Chemistry Vol. 282 ( 37 ) 2007
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Goto, N., Sugiura, K., Ogawa, Y., Watanabe, A., Onouchi, H., Tomita, Y., Muro, Y.
Journal of Autoimmunity Vol. 26 ( 1 ) 2006
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Regulation of fibroblast growth factor-23 signaling by Klotho Reviewed
Kurosu, H., Ogawa, Y., Miyoshi, M., Yamamoto, M., Nandi, A., Rosenblatt, K.P., Baum, M.G., Schiavi, S., Hu, M.-C., Moe, O.W., Kuro-o, M.
Journal of Biological Chemistry Vol. 281 ( 10 ) 2006
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Ogawa, Y., Mizumoto, N., Tanaka, H., Matsushima, H., Takashima, A.
Journal of Investigative Dermatology Vol. 126 ( 2 ) 2006
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HLA-associated production of anti-DFS70/LEDGF autoantibodies and systemic autoimmune disease Reviewed
Muro, Y., Ogawa, Y., Sugiura, K., Tomita, Y.
Journal of Autoimmunity Vol. 26 ( 4 ) 2006
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Discovery of novel immunostimulants by dendritic-cell-based functional screening Reviewed
Mizumoto, N., Gao, J., Matsushima, H., Ogawa, Y., Tanaka, H., Takashima, A.
Blood Vol. 106 ( 9 ) 2005
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Regulation of oxidative stress by the anti-aging hormone klotho Reviewed
Yamamoto, M., Clark, J.D., Pastor, J.V., Gurnani, P., Nandi, A., Kurosu, H., Miyoshi, M., Ogawa, Y., Castrillon, D.H., Rosenblatt, K.P., Kuro-O, M.
Journal of Biological Chemistry Vol. 280 ( 45 ) 2005
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Ogawa, Y., Adachi, A., Okamoto, M., Hashimoto, T., Tomita, Y.
Journal of Dermatology Vol. 31 ( 8 ) 2004
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Ogawa, Y., Sugiura, K., Watanabe, A., Kunimatsu, M., Mishima, M., Tomita, Y., Muro, Y.
Journal of Autoimmunity Vol. 23 ( 3 ) 2004
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Autoantibodies to DFS70/LEDGF are increased in alopecia areata patients Reviewed International journal
Okamoto, M., Ogawa, Y., Watanabe, A., Sugiura, K., Shimomura, Y., Aoki, N., Nagasaka, T., Tomita, Y., Muro, Y.
Journal of Autoimmunity Vol. 23 ( 3 ) page： 257 - 66 2004
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Ogawa, Y., Adachi, A., Tomita, Y.
Journal of Dermatology Vol. 30 ( 11 ) 2003
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Autoantibody to thioredoxin reductase in an ovarian cancer patient Reviewed
Muro, Y., Ogawa, Y., Kato, Y., Hagiwara, M.
Biochemical and Biophysical Research Communications Vol. 242 ( 2 ) 1998
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Shimomura, A., Ogawa, Y., Kitani, T., Fujisawa, H., Hagiwara, M.
Journal of Biological Chemistry Vol. 271 ( 30 ) 1996
MISC 11
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抗PM/Scl抗体陽性皮膚筋炎の3例はじめに
桃原 真理子, 室 慶直, 滝 奉樹, 小川 靖, 杉浦 一充, 秋山 真志, 岡地 祥太郎, 曽根 淳
中部リウマチ Vol. 46 ( 2 ) page： 37 - 37 2017.3
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ヒト表皮ケラチノサイトにおけるABCA12プロモーターの解析 プロモーター活性に必要なパリンドローム配列の同定
小川 靖, 清水 由隆, 杉浦 一充, 秋山 真志, 武田 淳一, 澤田 香織, 柳 輝希, 清水 宏, 今 淳, 澤村 大輔
角化症研究会記録集 Vol. 30 page： 18 - 21 2016.3
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片側優位性に症状を呈した点状掌蹠角化症の1例
滝 奉樹, 小川 靖, 秋山 真志, 榊原 彰浩
日本皮膚科学会雑誌 Vol. 126 ( 2 ) page： 195 - 195 2016.2
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TREX1新規変異p.Pro132Alaによる家族性凍瘡状狼瘡の1例
杉浦 一充, 武市 拓也, 河野 通浩, 小川 靖, 室 慶直, 秋山 真志
中部リウマチ Vol. 44 ( 1 ) page： 58 - 58 2014.7
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尋常性乾癬を伴わない汎発性膿疱性乾癬の大半はIL-36RN欠損症(DITRA)である
杉浦 一充, 武市 拓也, 河野 通浩, 小川 靖, 室 慶直, 秋山 真志, 武藤 正彦
日本皮膚科学会雑誌 Vol. 124 ( 5 ) page： 979 - 979 2014.4
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尋常性乾癬を伴わない汎発性膿疱性乾癬の大半はIL-36RN欠損症(DITRA)である
杉浦 一充, 武市 拓也, 河野 通浩, 小川 靖, 室 慶直, 秋山 真志, 武藤 正彦
日本皮膚科学会雑誌 Vol. 124 ( 2 ) page： 201 - 201 2014.2
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尋常性乾癬を伴わない汎発性膿疱性乾癬の大半はIL-36RN欠損症(DITRA)である
杉浦 一充, 武市 拓也, 河野 通浩, 小川 靖, 室 慶直, 武藤 正彦, 秋山 真志
Journal of Environmental Dermatology and Cutaneous Allergology Vol. 7 ( 5 ) page： 475 - 475 2013.11
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TREX1新規変異p.Pro132Alaによる家族性凍瘡状狼瘡の1例
杉浦 一充, 河野 通浩, 小川 靖, 室 慶直, 秋山 真志, 武市 拓也
日本皮膚科学会雑誌 Vol. 123 ( 4 ) page： 481 - 481 2013.4
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IL36RN新規変異p.Arg10Xによる家族性汎発性膿疱性乾癬の成人発症例
杉浦 一充, 河野 通浩, 小川 靖, 室 慶直, 秋山 真志, 武市 拓也
日本皮膚科学会雑誌 Vol. 123 ( 4 ) page： 461 - 461 2013.4
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LEDGF/DFS70の過剰発現はHaCaT細胞においてp38の活性化を介してIL-6を誘導する 新規乾癬ケラチノサイトモデル
武市 拓也, 杉浦 一充, 室 慶直, 小川 靖, 二村 恭子, 富田 靖
角化症研究会記録集 Vol. 25 page： 16 - 20 2011.3
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Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, which resembles psoriasis
Takuya Takeichi, Kazumitsu Sugiura, Yoshinao Muro, Kenji Matsumoto, Yasushi Ogawa, Kyoko Futamura, Yasushi Tomita
JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 130 page： S85 - S85 2010.9
KAKENHI (Grants-in-Aid for Scientific Research) 9
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A proof of concept study of medium chain trygryceride diet based treatment for congenital ichtgyosis
Grant number：17K10206 2017.4 - 2018.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship：Principal investigator
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
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Grant number：15H04887 2015.4 - 2018.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
AKIYAMA Masashi, ISHIKAWA Junko
Authorship：Coinvestigator(s)
In the present study, we accumulated families with inherited keratinization disorders including ichthyosis, and performed whole exome and/or whole genome sequencing using next generation sequencers to clarify genetic causes of the patients. Clinical information and data from the genetic analysis were collected as our data bank of patients with inherited keratinization disorders.
To elucidate the interaction between epidermal lipid synthesis and metabolism, and differentiation and proliferation of the epidermal keratinocytes, we analyzed detailed epidermal lipid profiles and differentiation/proliferation statuses of the keratinocytes in our mouse models of inherited ichthyoses. We comprehensively summarized the effects of epidermal functional lipids on differentiation and proliferation of the epidermal keratinocytes. From the present results, we considered novel therapeutic manners for keratinization disorders using epidermal functional lipids and lipid mediators. -
Dynamic epigenetic change of keratinocytes in inflammtory skin diseases
Grant number：26461657 2014.4 - 2018.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Yasushi Ogawa, AKIYAMA Masashi
Authorship：Principal investigator
Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）
This study aimed to investigate the roles of epigenetic changes of keratinocytes in the formation of inflammatory skin lesion of psoriasis. A reverse chemical genomics-approach was adopted. Topical imiquimod-induced skin inflammation was used as a mouse model of psoriasis, and various chemical inhibitors of chromatin modifying enzymes are applied to investigate their effect on the formation of the skin lesion. As a result we newly identified a histone demethylase inhibitor that promote the formation of the lesion, and a kinase inhibitor that suppress the skin lesion.
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Grant number：25670502 2013.4 - 2015.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
OGAWA Yasushi, SUGIURA Kazumitsu, AKIYAMA Masashi
Authorship：Principal investigator
Grant amount：\3770000 （ Direct Cost: \2900000 、 Indirect Cost：\870000 ）
This study was designed to verify the hypothesized feed forward mechanism of lipid metabolism-transcriptional regulation in differentiating keratinocytes, and find possible application of this putative mechanism in the treatment of congenital skin diseases. For this purpose we utilized Abca12-deficient as a mouse model of harlequin ichthyosis and CGI-58-deficient mouse as a model of neutral lipid storage disease with ichthyosis. Primary keratinocytes taken from the skin of model mice were treated with agonists of PPAR family nuclear receptors. A PPARγagonist restored the decreased expression of a keratinocyte differentiation marker. It could not, however, provide an overall reversal of the disease phenotype. An attempt to inject of PPAR agonist in utero failed to rescue the early death of newborn mice. Search for skin-specific triglyceride lipase was performed using siRNA targeted at PNPLA family members suggested the putative lipase exists otherwise.
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Impact of phosphate toxicity on skin aging
Grant number：24659527 2012.4 - 2013.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
OGAWA Yasushi
Authorship：Principal investigator
Grant amount：\3770000 （ Direct Cost: \2900000 、 Indirect Cost：\870000 ）
Hyperphosphatemia is caused by several diseases including chronic renal failure, and is often accompanied by skin manifestations that mimic aging. The "phosphate toxicity" hypothesis suggests that hyperphosphatemia induce aging like symptoms of the body, however, the direct consequence of the high phosphate condition on keratinocytes was not well studied.
In this study we verified that normal human epidermal keratinocytes (NHEK) are driven into early cellular senescence if cultured under non-optimum phosphate condition. NHEK showed highest population doubling levels (PDL) when cultured in 4 mM phosphate and the concentration lower or higher than this level resulted in decreased PDL. The decrease in PDL was accompanied by increased expression of keratinocyte differentiation markers. No increase in senescence associated secreted proteins was observed. It may be suggested that high phosphate condition may drive NHEK to differentiated state leading to accelerated aging-like phenotype. -
Grant number：23689054 2011.4 - 2015.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)
OGAWA Yasushi, SUGIURA Kazumitsu, AKIYAMA Masashi
Authorship：Principal investigator
Grant amount：\25090000 （ Direct Cost: \19300000 、 Indirect Cost：\5790000 ）
The present study examined a novel pathogenic mechanism of psoriasis where the epigenetic changes in affected keratinocytes promotes and stabilize the psoriatic skin lesions. The transcription activation cofactor LEDGF shows unique nuclear localization in the proliferating psoriatic keratinocytes. Our study revealed LEDGF shows extranuclear localization in G0/G1 keratinocyte cells, whereas upon stimulation with extracellular growth signals, it translocalizes to the nucleus via MEK and PI3K kinase-mediated mechanism. LEDGF was found to be a H3K36me3 reader, and when localized to the nucleus, it binds to the H3K36me3 motif and recruits the histone modification complex MLL. The present study is in support of the epigenetic model of psoriasis pathogenesis where the nuclear translocalized LEDGF enhances the di- and tri- methylation of H3K4 of the promoter regions of inflammatory cytokines and other psoriasis associated genes, leading to their enhanced and sustained expression.
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Investigation of two-step theory involved with TIF1-gamma in cancer-associated with dermatomyositis
Grant number：23591618 2011.4 - 2015.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
MURO YOSHINAO, SUGIURA Kazumitsu, OGAWA Yasushi
Authorship：Coinvestigator(s)
The pathogenic mechanisms has been still unknown in cancer-associated dermatomyositis (CADM). We investigated whether malignant tissues in CADM have the aberrant expression of TIF1-γ, which is a serological marker of CADM, and also investigated the possibility of interaction between TIF1-γ, and TGFβand other associated molecules. We showed the high expression of TIF1-γ
in malignant tissues in patients with anti-TIF1-γ and suggested the possibility of tumor growth by the phosphorylation of STAT3 through IL-6. -
Grant number：23249058 2011.4 - 2014.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
AKIYAMA Masashi, OGAWA Yasushi, KONO Michihiro, ABE Riichiro, SUGIURA Kazumitsu, MURO Yoshinao
Authorship：Coinvestigator(s)
In the present study, we established ABCA12-mutant mice harboring ABCA12 partial loss-of-function mutations, as model mice for congenital ichthyosiform erythroderma. In the model mice, we evaluated the up-regulation effects on ABCA12 gene expression by various compounds, which were expected to have up-regulation effects on ABCA12 gene expression. As for the compounds which were proved to have up-regulation effects on ABCA12 gene expression, we further investigated treatment efficacy of the up-regulators of ABCA12 gene expression in the model mice, by monitoring ichthyosis phenotype recovery and restoration of skin barrier function.
In addition, we also established model mice carrying ABCA12 loss-of-function mutations as a model of harlequin ichthyosis. Using the model mice, we evaluated treatment efficacy of various read-through compounds to harlequin ichthyosis phenotypes by monitoring restoration of the stratum corneum barrier function and phenotype recovery. -
Molecular Mechanism of Chemotherapy Resistance of Malignant Melanoma
Grant number：23659548 2011 - 2012
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
OGAWA Yasushi
Authorship：Principal investigator
Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）
Industrial property rights 2
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DYRKを阻害するベンゾチアゾール誘導体を含有する医薬組成物
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FGF21 Upregulates Expression of GLUT-1 in a βKlotho-Dependent Manner.