Faculty Profiles - SUZUKI, Yasuhiro

Presentations -

Division display 61 - 77 of about 77 ／ All the affair displays >>

Investigation of the protein-protein interaction network of yeast by using the social network analysis

タンパク質間相互作用ネットワークのモジュラーな進化

荻島創一, 鈴木泰博, 長谷武志, 中川草, 田中博

日本分子生物学会年会講演要旨集 2005.11.25

Network Design and its discussions by optimizing network distinctive quantity using Genetic Algorithms

佐藤史隆, 広安知之, 三木光範, 鈴木泰博

情報処理学会シンポジウム論文集 2005.10.11

Molecular Evolutionary Analysis of Yeast Protein Interaction Network

Soichi Ogishima, Takeshi Hase, So Nakagawa, Yasuhiro Suzuki, Hiroshi Tanaka

PROCEEDINGS OF WORLD ACADEMY OF SCIENCE, ENGINEERING AND TECHNOLOGY, VOL 6 2005 WORLD ACAD SCI, ENG & TECH-WASET

Event date： 2005

Language：English

To understand life as biological system, evolutionary understanding is indispensable. Protein interactions data are rapidly accumulating and are suitable for system-level evolutionary analysis. We have analyzed yeast protein interaction network by both mathematical and biological approaches. In this poster presentation, we inferred the evolutionary birth periods of yeast proteins by reconstructing phylogenetic profile. It has been thought that hub proteins that have high connection degree are evolutionary old. But our analysis showed that hub proteins are entirely evolutionary new. We also examined evolutionary processes of protein complexes. It showed that member proteins of complexes were tend to have appeared in the same evolutionary period. Our results suggested that protein interaction network evolved by modules that form the functional unit. We also reconstructed standardized phylogenetic trees and calculated evolutionary rates of yeast proteins. It showed that there is no obvious correlation between evolutionary rates and connection degrees of yeast proteins.

p53シグナル伝達系のモデリングおよびシミュレーション:Abstract Cell Modelでの試み

荻島創一, 鈴木泰博, 田中博

医療情報学連合大会論文集 2004.11.26