日本Archaea研究会   幹事

2006

極限環境生物学会

2018

American Society for Biochemistry and Molecular Biology

2016

American Society for Microbiology

2013

Italy-Japan Symposium New Trends in Enzyme Science and Engineering of Enzyme and Microbiology for Sustainable Society Organizing Committee   Organizing committee member, organizing secretariat  

2014.11   

農芸化学会中部支部第168回例会実行委員会   世話人  

2013.10   

第20回ドリコールおよびイソプレノイド研究会例会実行委員会   実行委員長  

2010.10   

Italy-Japan Symposium New Trends in Enzyme Science and Technology Organizing Committee   Committee member  

2009.10   

第61回日本生物工学会大会実行委員会   委員  

2009.9   

日本農芸化学会2008年度大会実行委員会   委員  

2008.3   

Japan-Italy Symposium of New Trends in Enzyme Science and Technology Organizing Committee   Committee member  

2006.11   

d-amino acid auxotrophic Escherichia coli strain for in vivo functional cloning of novel d-amino acid synthetic enzyme. Reviewed

Ito T, Muto N, Sakagami H, Tanaka M, Hemmi H, Yoshimura T

FEBS journal     2023.1

Identification and functional analysis of a new type of Z,E-mixed prenyl reductase from mycobacteria Reviewed

Abe Tohru, Hakamata Mariko, Nishiyama Akihito, Tateishi Yoshitaka, Matsumoto Sohkichi, Hemmi Hisashi, Ueda Daijiro, Sato Tsutomu

FEBS JOURNAL   Vol. 289 ( 16 ) page： 4981 - 4997   2022.8

Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways Reviewed International coauthorship

Aoki Mizuki, Vinokur Jeffrey, Motoyama Kento, Ishikawa Rino, Collazo Michael, Cascio Duilio, Sawaya Michael R., Ito Tomokazu, Bowie James U., Hemmi Hisashi

JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 298 ( 7 ) page： 102111   2022.7

Identification and characterization of a serine racemase in the silkworm Bombyx mori. Reviewed

Tanaka Y, Yoshimura T, Hakamata M, Saito C, Sumitani M, Sezutsu H, Hemmi H, Ito T

Journal of biochemistry   Vol. 172 ( 1 ) page： 17 - 28   2022.6

Identification and biochemical characterization of a heteromeric cis-prenyltransferase from the thermophilic archaeon Archaeoglobus fulgidus Reviewed

Sompiyachoke Kitty, Nagasaka Arisa, Ito Tomokazu, Hemmi Hisashi

JOURNAL OF BIOCHEMISTRY   Vol. 171 ( 6 ) page： 641 - 651   2022.5

Mechanism of Pyridoxine 5 '-Phosphate Accumulation in Pyridoxal 5 '-Phosphate-Binding Protein Deficiency Reviewed International coauthorship

Ito Tomokazu, Ogawa Honoka, Hemmi Hisashi, Downs Diana M., Yoshimura Tohru

JOURNAL OF BACTERIOLOGY   Vol. 204 ( 3 ) page： e0052121   2022.3

Isopentenyl diphosphate/dimethylallyl diphosphate-specific Nudix hydrolase from the methanogenic archaeon Methanosarcina mazei Reviewed

Ishibashi Yumi, Matsushima Natsumi, Ito Tomokazu, Hemmi Hisashi

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 86 ( 2 ) page： 246 - 253   2022.1

Evolution and properties of alanine racemase from Synechocystis sp. PCC6803 Reviewed

Ashida Hiroyuki, Murakami Kaho, Inagaki Kenji, Sawa Yoshihiro, Hemmi Hisashi, Iwasaki Yugo, Yoshimura Tohru

JOURNAL OF BIOCHEMISTRY   Vol. 171 ( 4 ) page： 421 - 428   2021.12

Total Synthesis and Structure Confirmation of trans-Anhydromevalonate-5-phosphate, a Key Biosynthetic Intermediate of the Archaeal Mevalonate Pathway Reviewed

Yasuno Yoko, Nakayama Atsushi, Saito Kai, Kitsuwa Kohei, Okamura Hironori, Komeyama Mutsumi, Hemmi Hisashi, Shinada Tetsuro

JOURNAL OF NATURAL PRODUCTS   Vol. 84 ( 10 ) page： 2749 - 2754   2021.10

Urinary l-erythro-β-hydroxyasparagine-a novel serine racemase inhibitor and substrate of the Zn2+-dependent d-serine dehydratase. Reviewed

Ito T, Tono M, Kitaura Y, Hemmi H, Yoshimura T

Bioscience reports   Vol. 41 ( 4 )   2021.4

A versatile cis-prenyltransferase from Methanosarcina mazei catalyzes both C- and O-prenylations Reviewed

Okada Miyako, Unno Hideaki, Emi Koh-Ichi, Matsumoto Mayuko, Hemmi Hisashi

JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 296   page： 100679   2021.4

古細菌型メバロン酸経路の発見 Invited Reviewed

邊見　久

生化学   Vol. 93 ( 2 ) page： 221 - 224   2021.4

Mechanism of eukaryotic serine racemase-catalyzed serine dehydration Reviewed

Ito Tomokazu, Matsuoka Mai, Goto Masaru, Watanabe Soichiro, Mizobuchi Taichi, Matsushita Kazuma, Nasu Ryoma, Hemmi Hisashi, Yoshimura Tohru

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS   Vol. 1868 ( 9 ) page： 140460   2020.9

Reconstruction of the "Archaeal" Mevalonate Pathway from the Methanogenic Archaeon Methanosarcina mazei in Escherichia coli Cells Reviewed

Yoshida Ryo, Yoshimura Tohru, Hemmi Hisashi

APPLIED AND ENVIRONMENTAL MICROBIOLOGY   Vol. 86 ( 6 )   2020.3

Inhibition of glycine cleavage system by pyridoxine 5 '-phosphate causes synthetic lethality in glyA yggS and serA yggS in Escherichia coli Reviewed International coauthorship

Ito Tomokazu, Hori Ran, Hemmi Hisashi, Downs Diana M., Yoshimura Tohru

MOLECULAR MICROBIOLOGY   Vol. 113 ( 1 ) page： 270 - 284   2020.1

Construction of an artificial biosynthetic pathway for hyperextended archaeal membrane lipids in the bacterium <i>Escherichia coli</i>. Reviewed

Yoshida R, Hemmi H

Synthetic biology (Oxford, England)   Vol. 5 ( 1 ) page： ysaa018   2020

A heteromeric cis-prenyltransferase is responsible for the biosynthesis of glycosyl carrier lipids in Methanosarcina mazei Reviewed

Emi Koh-ichi, Sompiyachoke Kitty, Okada Miyako, Hemmi Hisashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 520 ( 2 ) page： 291 - 296   2019.12

Conserved Pyridoxal 5 '-Phosphate-Binding Protein YggS Impacts Amino Acid Metabolism through Pyridoxine 5 '-Phosphate in Escherichia coli Reviewed International coauthorship

Ito Tomokazu, Yamamoto Kana, Hori Ran, Yamauchi Ayako, Downs Diana M., Hemmi Hisashi, Yoshimura Tohru

APPLIED AND ENVIRONMENTAL MICROBIOLOGY   Vol. 85 ( 11 )   2019.6

Conversion of Mevalonate 3-Kinase into 5-Phosphomevalonate 3-Kinase by Single Amino Acid Mutations Reviewed

Motoyama Kento, Sobue Fumiaki, Kawaide Hiroshi, Yoshimura Tohru, Hemmi Hisashi

APPLIED AND ENVIRONMENTAL MICROBIOLOGY   Vol. 85 ( 9 )   2019.5

Modified mevalonate pathway of the archaeon <i>Aeropyrum pernix</i> proceeds via <i>trans</i>-anhydromevalonate 5-phosphate. Reviewed

Hayakawa H, Motoyama K, Sobue F, Ito T, Kawaide H, Yoshimura T, Hemmi H

Proceedings of the National Academy of Sciences of the United States of America   Vol. 115 ( 40 ) page： 10034-10039   2018.9

D-Serine Metabolism and Its Importance in Development of Dictyostelium discoideum Reviewed

Ito Tomokazu, Hamauchi Natsuki, Hagi Taisuke, Morohashi Naoya, Hemmi Hisashi, Sato Yukie G., Saito Tamao, Yoshimura Tohru

FRONTIERS IN MICROBIOLOGY   Vol. 9   page： 784   2018.4

Production of Ophthalmic Acid Using Engineered Escherichia coli Reviewed

Ito Tomokazu, Tokoro Maiko, Hori Ran, Hemmi Hisashi, Yoshimura Tohru

APPLIED AND ENVIRONMENTAL MICROBIOLOGY   Vol. 84 ( 7 )   2018.4

Biosynthetic machinery for C-25,C-25-diether archaeal lipids from the hyperthermophilic archaeon Aeropyrum pernix Reviewed

Yoshida Ryo, Yoshimura Tohru, Hemmi Hisashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 497 ( 1 ) page： 87-92   2018.2

Utilization of an intermediate of the methylerythritol phosphate pathway, (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate, as the prenyl donor substrate for various prenyltransferases Reviewed

Hayashi Yoshifumi, Ito Tomokazu, Yoshimura Tohru, Hemmi Hisashi

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 82 ( 6 ) page： 993-1002   2018

Occurrence of the (2R,3S) -Isomer of 2-Amino-3,4-dihydroxybutanoic Acid in the Mushroom Hypsizygus marmoreus Reviewed

Ito Tomokazu, Yu Zhuoer, Yoshino Issei, Hirozawa Yurina, Yamamoto Kana, Shinoda Kiyotugu, Watanabe Akira, Hemmi Hisashi, Asada Yasuhiko, Yoshimura Tohru

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY   Vol. 65 ( 30 ) page： 6131-6139   2017.8

Identification of enzymes involved in the mevalonate pathway of Flavobacterium johnsoniae Reviewed

Hayakawa Hajime, Sobue Fumiaki, Motoyama Kento, Yoshimura Tohru, Hemmi Hisashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 487 ( 3 ) page： 702-708   2017.6

A Single Amino Acid Mutation Converts (R)-5-Diphosphomevalonate Decarboxylase into a Kinase Reviewed

Motoyama Kento, Unno Hideaki, Hattori Ai, Takaoka Tomohiro, Ishikita Hiroshi, Kawaide Hiroshi, Yoshimura Tohru, Hemmi Hisashi

JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 292 ( 6 ) page： 2457-2469   2017.2

メバロン酸経路の多様性 Invited

邊見　久

バイオサイエンスとインダストリー   Vol. 74 ( 1 ) page： 15-20   2016

大腸菌をプラットフォームとしたアーキア膜脂質生合成研究 Invited

邊見　久

酵素工学ニュース   ( 76 ) page： 11-15   2016

A cis-prenyltransferase from Methanosarcina acetivorans catalyzes both head-to-tail and nonhead-to-tail prenyl condensation Reviewed

Ogawa, T., Emi, K., Koga, K., Yoshimura, T. & Hemmi, H.

FEBS Journal   Vol. 283   page： 2369-2383   2016

Ophthalmic acid accumulation in an Escherichia coli mutant lacking the conserved pyridoxal 5'-phosphate-binding protein YggS Reviewed

Ito, T., Yamauchi, A., Hemmi, H. & Yoshimura, T.

Journal of Bioscience and Bioengineering   Vol. 122   page： 689-693   2016

A new member of MocR/GabR-type PLP-binding regulator of D-alanyl-D-alanine ligase in Brevibacillus brevis Reviewed

Takenaka, T., Ito, T., Miyahara, I., Hemmi, H. & Yoshimura T.

FEBS Journal   Vol. 282   page： 4201-4217   2015

Role of the aminotransferase domain in Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator Reviewed

Okuda, K., Kato, S., Ito, T., Shiraki, S., Kawase, Y., Goto, M., Kawashima, S., Hemmi, H., Fukada H. & Yoshimura T.

Molecular Microbiology   Vol. 95 ( 2 ) page： 245-257   2015

Domain characterization of Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator Reviewed

Okuda, K., Ito, T., Goto, M., Takenaka, T., Hemmi, H. & Yoshimura T.

Journal of Biochemistry   Vol. 158 ( 3 ) page： 225-234   2015

A highly selective biosynthetic pathway to non-natural C₅₀ carotenoids assembled from moderately selective enzymes Reviewed

Furubayashi, M., Ikezumi, M., Takaichi, S., Maoka, T., Hemmi, H., Ogawa, T., Saito, K., Tobias, A.V. & Umeno, D.

Nature Communications   Vol. 6   page： 7534   2015

A phytoene desaturase homolog gene from the methanogenic archaean Methanosarcina acetivorans is responsible for hydroxyarchaeol biosynthesis Reviewed

Mori, T., Isobe, K., Ogawa, T., Yoshimura, T. & Hemmi, H.

Biochemical and Biophysical Research Communications   Vol. 466   page： 186-191   2015

In vivo formation of the protein disulfide bond that enhances the thermostability of diphosphomevalonate decarboxylase, an intracellular enzyme from the hyperthermophilic archaean Sulfolobus solfataricus Reviewed

Hattori, A., Unno, H., Goda, S., Motoyama, K., Yoshimura, T. & Hemmi, H.

Journal of Bacteriology   Vol. 197 ( 21 ) page： 3463-3471   2015

PEGylated D-serine dehydratase as a D-serine reducing agent Reviewed

Ito, T., Takada, H., Isobe, K., Suzuki, M., Kitaura, Y., Hemmi, H., Matsuda, T. & Yoshimura T.

Journal of Pharmaceutical and Biomedical Analysis   Vol. 116   page： 34-39   2015

Reaction mechanism of Zn²⁺-dependent D-serine dehydratase: role of a conserved tyrosine residue interacting with pyridine ring nitrogen of pyridoxal 5'-phosphate Reviewed

Ito, T., Matsuoka, M., Koga, K., Hemmi, H. & Yoshimura, T.

Journal of Biochemistry   Vol. 156   page： 173-180   2014

A novel geranylgeranyl reductase from the methanogenic archaeon Methanosarcina acetivorans displays unique regiospecificity Reviewed

Ogawa, T., Isobe, K., Mori, T., Asakawa, S., Yoshimura, T. & Hemmi, H.

FEBS Journal   Vol. 281   page： 3165-3176   2014

(R)-mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum Reviewed

Azami, Y., Hattori, A., Nishimura, H., Kawaide, H., Yoshimura, T. & Hemmi, H.

Journal of Biological Chemistry   Vol. 289   page： 15957-15967   2014

Geranylgeranyl reductase and ferredoxin from Methanosarcina acetivorans are required for the synthesis of fully reduced archaeal membrane lipid in Escherichia coli cells Reviewed

Isobe, K., Ogawa, T., Hirose, K., Yokoi, T., Yoshimura, T. & Hemmi, H.

Journal of Bacteriology   Vol. 196   page： 417-423   2014

Conserved pyridoxal protein that regulates Ile nad Val metabolism Reviewed

Ito, T., Iimori, J., Takayama, S., Moriyama, A., Yamauchi, A., Hemmi, H. & Yoshimura, T.

Journal of Bacteriology   Vol. 195   page： 5439-5449   2013

Substrate specificity of undecaprenyl diphosphate synthase from the hyperthermophilic archaeon Aeropyrum pernix Reviewed

Mori, T., Ogawa, T., Yoshimura, T. & Hemmi, H.

Biochemical and Biophysical Research Communications   Vol. 436   page： 230-234   2013

Biochemical evidence supporting the presence of the classical mevalonate pathway in the thermoacidophilic archaeon Sulfolobus solfataricus Reviewed

Nishimura, H., Azami, Y., Miyagawa, M., Hashimoto, C., Yoshimura, T. & Hemmi, H.

Journal of Biochemistry   Vol. 153   page： 415-420   2013

Catalytic mechanism of serine racemase from Dictyostelium discoideum Reviewed

Ito, T., Maekawa, M., Hayashi, S., Goto, M., Hemmi, H. & Yoshimura, T.

Amino Acids   Vol. 44   page： 1073-1084   2013

Substrate-induced change in the quaternary structure of type 2 isopentenyl diphosphate isomerase from Sulfolobus shibatae Reviewed

Nakatani, H., Goda, S., Unno, H., Nagai, T., Yoshimura, T. & Hemmi, H.

Journal of Bacteriology   Vol. 194   page： 3216-3224   2012

Quantitative analyses of the behavior of exogenously added bacteria during an acidulocomposting process Reviewed

Suematsu, T., Yamashita, S., Hemmi, H., Yoshinari, A., Shimoyama, T., Nakayama, T. & Nishino, T.

Journal of Bioscience and Bioengineering   Vol. 114   page： 70-72   2012

Metal ion dependency of serine rasemase from Dictyostelium discoideum Reviewed

Ito, T., Murase, H., Maekawa, M., Goto, M., Hayashi, S., Saito, H., Maki, M., Hemmi, H., & Yoshimura, T.

Amino Acids   Vol. 43   page： 1567-1576   2012

Role of Zinc Ion for Catalytic Activity in D-Serine Dehydratase from Saccharomyces cerevisiae Reviewed

Ito, T., Koga, K., Hemmi, H., & Yoshimura, T.

FEBS Journal.   Vol. 279   page： 612-624   2012

Archaeal phospholipid biosynthetic pathway reconstructed in Escherichia coli Reviewed

Yokoi, T., Isobe, K., Yoshimura, T. & Hemmi, H.

Archaea   Vol. 2012   page： ID 438931   2012

Lysine racemase from a lactic acid bacterium, Oenococcus oeni: Structural basis of substrate specificity Reviewed

Kato, S., Hemmi, H. & Yoshimura, T.

Journal of Biochemistry   Vol. 152   page： 505-508   2012

Enzymatic assay for D-aspartic acid using D-aspartate oxidase and oxaloacetate decarboxylase Reviewed

Kato, S., Ikuta, T., Hemmi, H., Takahashi, S., Kera, Y & Yoshimura, T.

Bioscience, Biotechnology, and Biochemistry   Vol. 76   page： 2150-2152   2012

Covalent modification of reduced flavin mononucleotide in type-2 isopentenyl diphosphate isomerase by active-site-directed inhibitors Reviewed

Nagai, T., Unno, H., Janczak, M.W., Yoshimura, T., Poulter, C.D. & Hemmi, H.

Proceedings of the National Academy of Sciences of the United States of America   Vol. 108   page： 20461-20466   2011

Simultaneous determination of D-amino acids by the coupling method of D-amino acid oxidase with high-performance liquid chromatography Reviewed

Kato, S., Kito, Y., Hemmi, H., & Yoshimura, T.

Journal of Chromatography B   Vol. 111   page： 104-108   2011

Connected cavity structure enables prenyl elongation across the dimer interface in mutated geranylfarnesyl diphosphate synthase from Methanosarcina mazei Reviewed

Ogawa, T., Yoshimura, T. & Hemmi, H.

Biochemical and Biophysical Research Communications   Vol. 409   page： 333-337   2011

Structure and mutation analysis of archaeal geranylgeranyl reductase Reviewed

Sasaki, D., Fujihashi, M., Iwata, Y., Murakami, M., Yoshimura, T., Hemmi, H. & Miki, K.

Journal of Molecular Biology   Vol. 409   page： 543-557   2011

Alterations in D-amino acid concentrations and microbial community structures during the fermentation of red and white wines

Kato, S., Ishihara, T., Hemmi, H., Kobayashi, H. & Yoshimura, T.

Journal of Bioscience and Bioengineering   Vol. 111   page： 104-108   2011

ユニークなフラビン酵素：タイプ2イソペンテニル二リン酸イソメラーゼ

邊見　久

生化学   Vol. 83 ( 4 ) page： 304-307   2011

古細菌イソプレノイド生合成に関わるタイプ２イソペンテニル二リン酸イソメラーゼにおけるフラビン補酵素の特異な機能 Invited Reviewed

邊見　久

ビタミン   Vol. 85 ( 1 ) page： 1-8   2011

Bacillus subtilis spore coat protein LipC is a phospholipase B Reviewed

Masayama, A., Kato, S., Terashima, T., Molgaard, A., Hemmi, H., Yoshimura, T. & Moriyama, R.

Bioscience, Biotechnology, and Biochemistry   Vol. 74   page： 24-30   2010

Biochemical analysis of a novel lipolytic enzyme YvdO from Bacillus subtilis 168 Reviewed

Kato, S., Yoshimura, T., Hemmi, H. & Moriyama, R.

Bioscience, Biotechnology, and Biochemistry   Vol. 74   page： 701-706   2010

Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution Reviewed

Ogawa, T., Yoshimura, T. & Hemmi, H.

Biochemical and Biophysical Research Communications   Vol. 393   page： 16-20   2010

A highly sensitive enzymatic assay for D- and total serine detection using D-serine dehydratase from Saccharomyces cerevisiae Reviewed

Naka, T., Ito, T., Hemmi, H. & Yoshimura, T.

Journal of Molecular Catalysis B: Enzymatic   Vol. 67   page： 150-154   2010

イソプレノイド代謝にみるフラビン補酵素のユニークな機能

邊見　久

バイオサイエンスとインダストリー   Vol. 68 ( 6 ) page： 421-423   2010

フラビン酵素の新機能？

邊見　久

生物工学会誌   Vol. 88 ( 3 ) page： 122   2010

アーキアにおける膜脂質生合成 Invited Reviewed

邊見　久

化学と生物   Vol. 48 ( 9 ) page： 614-621   2010

Flavin's new role as a general acid-base catalyst with no redox function in type 2 isopentenyl diphosphate isomerase Reviewed

Unno, H., Yamashita, S., Ikeda, Y., Sekiguchi, S., Yoshida, N., Yoshimura, T., Kusunoki, M., Nakayama, T., Nishino, T. & Hemmi, H.

Journal of Biological Chemistry   Vol. 284   page： 9160-9167   2009

Physiological role of carbon dioxide in spore germination of Clostridium perfringens S40 Reviewed

Kato, S., Masayama, A., Yoshimura, T., Hemmi, H., Tsunoda, H., Kihara, T. & Moriyama, R.

Journal of Bioscience and Bioengineering   Vol. 108   page： 477-483   2009

Polymerase chain reaction-denaturing gradient gel electrophoresis analysis of microbial community structure in landfill leachate Reviewed

Uchida, M., Hatayoshi, H., Syuku-nobe, A., Shimoyama, T., Nakayama, T., Okuwaki, A., Nishino, T. & Hemmi, H.

Journal of Hazardous Materials   Vol. 164   page： 1503-1508   2009

Effect of mutagenesis at the region upstream from the G(Q/E) motif of three types of geranylgeranyl diphosphate synthase on product chain-length Reviewed

Noike, M., Katagiri, T., Nakayama, T., Nishino, T. & Hemmi, H.

Journal of Bioscience and Bioengineering   Vol. 107   page： 235-239   2009

The implication of YggT of Escherichia coli in osmotic regulation Reviewed

Ito, T., Uozumi, N., Nakamura, T., Takayama, S., Matsuda, N., Aiba, H., Hemmi, H. & Yoshimura, T.

Journal of Bioscience and Bioengineering   Vol. 73   page： 2698-2704   2009

A novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae Reviewed

Ito, T., Hemmi, H., Kataoka, K., Mukai, Y. & Yoshimura, T.

Biochemical Journal   Vol. 409   page： 399-406   2008

Reaction mechanism of type 2 isopentenyl diphosphate isomerase Invited Reviewed

Hisashi Hemmi

Vitamins   Vol. 82 ( 11 ) page： 581-588   2008

The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction Reviewed

Noike, M., Katagiri, T., Nakayama, T., Koyama, T., Nishino, T. & Hemmi, H.

FEBS Journal   Vol. 275   page： 3921-3933   2008

Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl-donor, not a dead-end product Reviewed

Sato, S., Murakami, M., Yoshimura, T. & Hemmi, H.

Journal of Bacteriology   Vol. 190   page： 3923-3929   2008

Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus Reviewed

Murakami, M., Shibuya, K., Nakayama, T., Nishino, T., Yoshimura, T., Hemmi, H.

FEBS Journal   Vol. 274   page： 805-814   2007

アーキアにおけるイソプレノイド脂質の生合成：生体化合物の進化の歴史は解明可能だろうか？

邊見　久

化学と生物   Vol. 45 ( 9 ) page： 596-598   2007

タイプ２イソペンテニル二リン酸イソメラーゼにおけるFMNの役割

邊見　久、吉村　徹

ビタミン   Vol. 81 ( 10 ) page： 504-506   2007

Enzyme assay of D-serine dehydratase from Saccharomyces cerevisiae Reviewed

Ito, T., Takahashi, K., Naka, T., Hemmi, H. & Yoshimura, T.

Analytical Biochemistry   Vol. 371   page： 167-172   2007

Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer Reviewed

Doukov, T.I., Hemmi, H., Drennan, C.L., Ragsdale, S.W.

Journal of Biological Chemistry   Vol. 282   page： 6609-6618   2007

A novel lipolytic enzyme, YcsK (LipC), located in the spore coat of Bacillus subtilis, is involved in spore germination Reviewed

Masayama, A., Kuwana, R., Takamatsu, H., Hemmi, H., Yoshimura, T., Watabe, K., Moriyama, R.

Journal of Bacteriology   Vol. 189   page： 2369-2375   2007

Total synthesis of geranylgeranylglyceryl phosphate enantiomers: substrates for characterization of 2,3-O-digeranylgeranylglyceryl phosphate synthase Reviewed

Zhang, H., Shibuya, K., Hemmi, H., Nishino, T. & Prestwich, G.D.

Organic Letters   Vol. 8   page： 943-946   2006

Microbacterium natoriense sp. nov., a novel D-aminoacylase-producing bacterium isolated from soil in Natori, Japan Reviewed

Liu, J., Nakayama, T., Hemmi, H., Asano, Y., Tsuruoka, N., Shimomura, K., Nishijima, M. & Nishino, T.

International Journal of Systematic and Evolutionary Microbiology   Vol. 55   page： 611-615   2005

Menaquinone-specific prenyl reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus Reviewed

Hemmi, H., Takahashi, Y., Shibuya, K., Nakayama, T. & Nishino, T.

Journal of Bacteriology   Vol. 187   page： 1937-1944   2005

UDP-glucuronic acid: Anthocyanin glucuronosyltransferase from red daisy (Bellis perennis) flowers enzymology and phylogenetics of a novel glucuronosyltransferase involved in flower pigment biosynthesis Reviewed

Sawada, S., Suzuki, H., Ichimaida, F., Yamaguchi, M. A., Iwashita, T., Fukui, Y., Hemmi, H., Nishino, T. & Nakayama, T.

Journal of Biological Chemistry   Vol. 280   page： 899-906   2005

Microbial diversity in bio-degradation and re-utilization processes of garbage Reviewed

Haruta, S., Nakayama, T., Nakamura, K., Hemmi, H., Ishii, M., Igarashi, Y. & Nishino, T.

Journal of Bioscience and Bioengineering   Vol. 99   page： 1-11   2005

Molecular biological analysis of microflora in a garbage treatment process under thermoacidophilic conditions Reviewed

Hemmi, H., Shimoyama, T., Nakayama, T., Hoshi, K. & Nishino, T.

Journal of Bioscience and Bioengineering   Vol. 97   page： 119-126   2004

Molecular cloning and characterization of a thermostable carboxylesterase from an archaeon, Sulfolobus shibatae DSMZ5389: a non-linear kinetic behavior of a hormone-sensitive lipase family enzyme Reviewed

Ejima, K., Liu, J., Oshima, Y., Hirooka, K., Shimanuki, S., Hemmi, H., Nakayama, T. & Nishino, T.

Journal of Bioscience and Bioengineering   Vol. 98   page： 445-451   2004

(S)-2,3-Di-O-geranylgeranylglyceryl phosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. Molecular cloning and characterization of a membrane-intrinsic prenyltransferase involved in the biosynthesis of archaeal ether-linked membrane lipids Reviewed

Hemmi, H., Shibuya, K., Takahashi, Y., Nakayama, T. & Nishino, T.

Journal of Biological Chemistry   Vol. 279   page： 50197-50203   2004

Catalytic mechanism of type 2 isopentenyl diphosphate:dimethylallyl diphosphate isomerase: verification of a redox role of the flavin cofactor in a reaction with no net redox change Reviewed

Hemmi, H., Ikeda, Y., Yamashita, S., Nakayama, T. & Nishino, T.

Biochemical and Biophysical Research Communications   Vol. 322   page： 905-910   2004

Type 2 isopentenyl diphosphate isomerase from a thermoacidophilic archaeon Sulfolobus shibatae Reviewed

Yamashita, S., Hemmi, H., Ikeda, Y., Nakayama, T. & Nishino, T.

European Journal of Biochemistry   Vol. 271   page： 1087-1093   2004

Acidulocomposting, an accelerated composting process of garbage under thermoacidophilic conditions for prolonged periods Reviewed

Nishino, T., Nakayama, T., Hemmi, H., Shimoyama, T., Yamashita, S., Akai, M., Kanagawa, T., & Hoshi, K.

Journal of Environmental Biotechnology   Vol. 3   page： 33-36   2003

An alternative mechanism of product chain-length determination in type III geranylgeranyl diphosphate synthase Reviewed

Hemmi, H., Noike, M., Nakayama, T. & Nishino, T.

European Journal of Biochemistry   Vol. 270   page： 2186-2194   2003

Fusion-type lycopene β-cyclase from a thermoacidophilic archaeon Sulfolobus solfataricus Reviewed

Hemmi, H., Ikejiri, S., Nakayama, T. & Nishino, T.

Biochemical and Biophysical Research Communications   Vol. 305   page： 586-591   2003

Introduction of the archaebacterial geranylgeranyl pyrophosphate synthase gene into Chlamydomonas reinhardtii chloroplast Reviewed

Fukusaki, E. I., Nishikawa, T., Kato, K., Shinmyo, A., Hemmi, H., Nishino, T. & Kobayashi, A.

Journal of Bioscience and Bioengineering   Vol. 95   page： 283-287   2003

Collagenolytic serine-carboxyl proteinase from Alicyclobacillus sendaiensis strain NTAP-1: Purification, characterization, gene cloning, and heterologous expression Reviewed

Tsuruoka, N., Nakayama, T., Ashida, M., Hemmi, H., Nakao, M., Minakata, H., Oyama, H., Oda, K. & Nishino, T.

Applied and Environmental Microbiology   Vol. 69   page： 162-169   2003

Alicyclobacillus sendaiensis sp nov., a novel acidophilic, slightly thermophilic species isolated from soil in Sendai, Japan Reviewed

Tsuruoka, N., Isono, Y., Shida, O., Hemmi, H., Nakayama, T. & Nishino, T.

International Journal of Systematic and Evolutionary Microbiology   Vol. 53   page： 1081-1084   2003

Altering the substrate chain-length specificity of an α-glucosidase Reviewed

Noguchi, A., Nakayama, T., Hemmi, H. & Nishino, T.

Biochemical and Biophysical Research Communications   Vol. 304   page： 684-690   2003

Deciphering the molecular basis of the broad substrate specificity of α-glucosidase from Bacillus sp SAM1606 Reviewed

Noguchi, A., Yano, M., Ohshima, Y., Hemmi, H., Inohara-Ochiai, M., Okada, M., Min, K. S., Nakayama, T. & Nishino, T.

Journal of Biochemistry   Vol. 134   page： 543-550   2003

Deletion and insertion of a 192-residue peptide in the active-site domain of glycosyl hydrolase family-2 β-galactosidases Reviewed

Inohara-Ochiai, M., Hasegawa, S., Iguchi, S., Ashikari, T., Shibano, Y., Hemmi, H., Nakayama, T. & Nishino, T.

Journal of Bioscience and Bioengineering   Vol. 93   page： 575-583   2002

Novel medium-chain prenyl diphosphate synthase from the thermo acidophilic archaeon Sulfolobus solfataticus Reviewed

Hemmi, H., Ikejiri, S., Yamashita, S. & Nishino, T.

Journal of Bacteriology   Vol. 184   page： 615-620   2002

Novel sugar phosphotransferase system applicable to the efficient labeling of the compounds synthesized via the non-mevalonate pathway in Escherichia coli Reviewed

Hemmi, H., Yamashita, S., Nakayama, T. & Nishino, T.

Journal of Bioscience and Bioengineering   Vol. 93   page： 515-518   2002

Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations Reviewed

Hemmi, H., Noike, M., Nakayama, T. & Nishino, T.

Biochemical and Biophysical Research Communications   Vol. 297   page： 1096-1101   2002

Site-specific mutagenesis at positions 272 and 273 of the Bacillus sp SAM1606 α-glucosidase to screen mutants with altered specificity for oligosaccharide production by transglucosylation Reviewed

Okada, M., Nakayama, T., Noguchi, A., Yano, M., Hemmi, H., Nishino, T. & Ueda, T.

Journal of Molecular Catalysis B-Enzymatic   Vol. 16   page： 265-274   2002

Dramatic changes in the substrate specificities of prenyltransferase by a single amino acid substitution Reviewed

Maki, Y., Komabayashi, M., Gotoh, Y., Ohya, N., Hemmi, H., Hirooka, K., Nishino, T. & Koyama, T.

Journal of Molecular Catalysis B-Enzymatic   Vol. 19   page： 431-436   2002

Cloning, expression, and characterization of cis-polyprenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus acidocaldarius Reviewed

Hemmi, H., Yamashita, S., Shimoyama, T., Nakayama, T. & Nishino, T.

Journal of Bacteriology   Vol. 183   page： 401-404   2001

ホスミドマイシンー抗マラリア薬としての再発見

邊見　久

生物工学会誌   Vol. 78 ( 8 ) page： 338   2000

The role of histidine-114 of Sulfolobus acidocaldarius geranylgeranyl diphosphate synthase in chain-length determination Reviewed

Hirooka, K., Kato, T., Matsu-ura, J., Hemmi, H. & Nishino, T.

FEBS Letters   Vol. 481   page： 68-72   2000

Zinc biosorption by a zinc-resistant bacterium, Brevibacterium sp strain HZM-1 Reviewed

Taniguchi, J., Hemmi, H., Tanahashi, K., Amano, N., Nakayama, T. & Nishino, T.

Applied Microbiology and Biotechnology   Vol. 54   page： 581-588   2000

An active-site mutation causes enhanced reactivity and altered regiospecificity of transglucosylation catalyzed by the Bacillus sp SAM1606 α-glucosidase Reviewed

Inohara-Ochiai, M., Okada, M., Nakayama, T., Hemmi, H., Ueda, T., Iwashita, T., Kan, Y., Shibano, Y., Ashikari, T. & Nishino, T.

Journal of Bioscience and Bioengineering   Vol. 89   page： 431-437   2000

Identification of genes affecting lycopene formation in Escherichia coli transformed with carotenoid biosynthetic genes: Candidates for early genes in isoprenoid biosynthesis Reviewed

Hemmi, H., Ohnuma, S., Nagaoka, K. & Nishino, T.

Journal of Biochemistry   Vol. 123   page： 1088-1096   1998

Overexpression of an archaeal geranylgeranyl diphosphate synthase in Escherichia coli cells Reviewed

Ohto, C., Nakane, H., Hemmi, H., Ohnuma, S., Obata, S. & Nishino, T.

Bioscience Biotechnology and Biochemistry   Vol. 62   page： 1243-1246   1998

Recognition of allylic substrates in Sulfolobus acidocaldarius geranylgeranyl diphosphate synthase: Analysis using mutated enzymes and artificial allylic substrates Reviewed

Ohnuma, S., Hemmi, H., Koyama, T., Ogura, K. & Nishino, T.

Journal of Biochemistry   Vol. 123   page： 1036-1040   1998

Effects of random mutagenesis in a putative substrate-binding domain of geranylgeranyl diphosphate synthase upon intermediate formation and substrate specificity Reviewed

Ohnuma, S., Hemmi, H., Ohto, C., Nakane, H. & Nishino, T.

Journal of Biochemistry   Vol. 121   page： 696-704   1997

Conversion from farnesyl diphosphate synthase to geranylgeranyl diphosphate synthase by random chemical mutagenesis Reviewed

Ohnuma, S. I., Nakazawa, T., Hemmi, H., Hallberg, A. M., Koyama, T., Ogura, K. & Nishino, T.

Journal of Biological Chemistry   Vol. 271   page： 10087-10095   1996

Conversion of product specificity of archaebacterial geranylgeranyl-diphosphate synthase - Identification of essential amino acid residues for chain length determination of prenyltransferase reaction Reviewed

Ohnuma, S., Hirooka, K., Hemmi, H., Ishida, C., Ohto, C. & Nishino, T.

Journal of Biological Chemistry   Vol. 271   page： 18831-18837   1996

未培養真正細菌に存在する古細菌型メバロン酸経路

邊見　久, Riko Kuriki, 吉田　稜

第３０回イソプレノイド研究会例会 

アーキア膜脂質：生合成研究とエンジニアリングへの展開 Invited

邊見　久

2019年度卓越大学院GTR成果報告会 

「緩い」基質認識が可能にするプレニル基転移反応のリデザイン Invited

邊見　久

生合成リデザイン第7回公開シンポジウム 

超好熱性アーキアAeropyrum pernix由来ホスホ-trans-アンヒドロメバロン酸デカルボキシラーゼの特性評価

邊見　久, 松嶋夏海, 品田哲郎, 吉村　徹

第２０回極限環境生物学会年会 

Discovery of a 'fourth' mevalonate pathway from the hyperthermophilic archaeon Aeropyrum pernix Invited International conference

Hisashi Hemmi

Thermophiles 2019 15th International Congress on Thermophiles 

超好熱アーキアに見出した「第４の」メバロン酸経路 Invited

邊見　久

微生物ウィーク2019 シンポジウム「好熱菌研究最前線」 

古細菌型メバロン酸経路の発見 Invited

邊見　久

2019年度日本農芸化学会大会 

Creation of mevalonate decarboxylase for the production of a second-generation biofuel, isoprenol Invited

超好熱性アーキアから見出された新奇な変形メバロン酸経路

邊見　久, 早川　祝, 本山　賢人, 祖父江史明, 川出　洋, 吉村　徹

第９１回日本生化学会大会 

A novel modified mevalonate pathway identified from a hyperthemophilic archaeon Aeropyrum pernix International conference

Hisashi Hemmi, Hajime Hayakawa, Kento Motoyama, Fumiaki Sobue, Tomokazu Ito, Hiroshi Kawaide, and Tohru Yoshimura

Extremophiles 2018: 12th International Congress of Extremophiles 

RIトレーサー実験による古細菌メバロン酸経路の解明 Invited

邊見　久

第４２回国立大学ラジオアイソトープ総合センター長会議 

アーキアにおけるメバロン酸経路の多様性 Invited

邊見　久

第12回日本ゲノム微生物学会シンポジウム「アーキアのゲノムバイオロジー〜ゲノム研究が解き明かす新しいアーキアの姿〜」 

古細菌の耐熱性と膜脂質の関係 Invited

邊見　久

Diversity and evolution of the mevalonate pathways in archaea Invited International conference

Hisashi Hemmi, Kento Motoyama, Ai Hattori, Hideaki Unno, Hiroshi Kawaide, Tohru Yoshimura

Japan-Italy Joint Symposium: New Trends in Enzyme and Microbial Science in the Translational Biology Era 

Mutation-induced conversion of diphosphomevalonate decarboxylase into a kinase International conference

Hisashi Hemmi, Kento Motoyama, Hiroshi Kawaide and Tohru Yoshimura

TERPNET 2017 13th International Meeting on Biosynthesis, Function and Synthetic Biology of Isoprenoids 

部位特異的変異導入による好熱性古細菌由来メバロン酸3-キナーゼの基質特異性および触媒機能の改変

本山健人、川出　洋、吉村　徹、邊見　久

2017年度酵素補酵素研究会 

Evolution of the mevalonate pathways in Archaea International conference

Hisashi Hemmi

2nd US-Japan Seminar on the Biosynthesis of Natural Products for Young Researchers 

アーキアにおけるメバロン酸経路の多様性とその進化

邊見　久

第89回日本生化学会大会 

Conversion of 5-diphosphomevalonate decarboxylase into 3-kinase International conference

Hisashi Hemmi, Kento Motoyama, Ai Hattori, and Tohru Yoshimura

The 5th International Conference on Cofactors and Active Enzyme Molecule 2016 

好熱性アーキアSulfolobus solfataricus由来ジホスホメバロン酸デカルボキシラーゼの耐熱性に寄与するサブユニット間ジスルフィド結合

邊見　久，服部　愛，海野英昭，郷田秀一郎，本山賢人，吉村　徹

日本Archaea研究会第29回講演会 

分岐型プレニル二リン酸を与えるメタン生成古細菌由来酵素の研究

邊見　久、小川拓哉、江見晃一、吉村　徹

2015年度日本農芸化学会中部・関西支部合同大会 

メタン生成アーキアのシス型プレニルトランスフェラーゼホモログによる分 岐型プレニル二リン酸の合成

邊見 久、小川拓哉、吉村 徹

第２５回 イソプレノイド研究会例会 

Thermoplasma型変形メバロン酸経路とメバロン酸3-キナーゼ

邊見 久、生明 靖裕、本山 健人、服部 愛、吉村 徹

2015年度 酵素補酵素研究会 

Thermoplasma-type modified mevalonate pathway and mevalonate 3-kinase International conference

Hisashi Hemmi, Yasuhiro Azami, Kento Motoyama, Ai Hattori and Tohru Yoshimura

TERPNET 2015 12th International Meeting on Biosynthesis, Function and Synthetic Biology of Isoprenoids 

Mevalonate 3-phosphate is an intermediate of the mevalonate pathway in the thermophilic archaeon Thermoplasma acidophilus International conference

Hisashi Hemmi, Yasuhiro Azami, Ai Hattori, Hiroto Nishimura, Hiroshi Kawaide and Tohru Yoshimura

Japan-Italy Joint Symposium: New Trends in Science and Engineering of Enzyme and Microbiology for Sustainable Society 

Thermoplasma acidophilumより見出された第３のメバロン酸経路

邊見　久、生明靖裕、服部　愛、西村泰斗、川出　洋、吉村　徹

日本Archaea研究会第２７回講演会 

大腸菌をプラットフォームとしたアーキア特異的イソプレノイド脂質の生合成研究

邊見　久

2014年度日本農芸化学会大会 

A third alternative mevalonate pathway from Thermoplasma acidophilum International conference

Hisashi Hemmi, Yasuhiro Azami, Ai Hattori, Hiroshi Kawaide and Tohru Yoshimura

1st US-Japan Seminar on the Biosynthesis of Natural Products for Young Researchers 

新規なアプローチによるアーキア膜脂質の生合成研究

邊見　久

第８６回日本生化学会大会 

Biosynthesis of intact archaeal membrane lipid in bacterial cells International conference

Hisashi Hemmi, Keisuke Isobe, Takeru Yokoi and Tohru Yoshimura

Gordon Research Conference on Archaea: Ecology, Metabolism & Molecular Biology 

バクテリア細胞中における完全飽和アーキア脂質の生合成 International conference

邊見　久、磯部圭祐、吉村　徹

日本Archaea研究会第２６回講演会 

アーキア膜脂質生合成に関わる新奇フラビン酵素（１）

邊見　久、磯部圭祐、吉村　徹

日本ビタミン学会第６５回大会 

タイプ２イソペンテニル二リン酸イソメラーゼにおけるフラビン補酵素の触媒機能

邊見　久

2013年度日本農芸化学会大会 

Substrate-induced change in the quaternary structure of type 2 isopentenyl diphosphate isomerase from Sulfolobus shibatae

Hisashi Hemmi

mechanism-based inhibitorを用いたタイプ２イソペンテニル二リン酸イソメラーゼの反応機構解析

邊見　久

2012年度酵素・補酵素研究会 

Archaeal phospholipid biosynthesis pathway reconstructed in E. coli International conference

Takeru Yokoi, Keisuke Isobe, Tohru Yoshimura and Hisashi Hemmi

The International Conference of Natural Product Biosynthesis (8th US-Japan Seminar on the Biosynthesis of Natural Products: Enzymology, Structural Biology, Drug Discovery, Genome Mining) 

アーキア膜脂質生合成に関わるゲラニルゲラニルレダクターゼの構造機能相関

邊見　久

第８４回日本生化学会大会 

Structure-function relationship in archaeal geranylgeranyl reductase International conference

Hisashi Hemmi, Yuki Iwata, Daisuke Sasaki, Masahiro Fujihashi, Motomichi Murakami, Tohru Yoshimura, and Kunio Miki

Gordon Research Conference on Archaea: Ecology, Metabolism & Molecular Biology 

Non-redox catalysis by reduced flavin mononucleotide in type 2 isopentenyl diphosphate isomerase International conference

Hisashi Hemmi

17th International Symposium on Flavins and Flavoproteins 

タイプ２イソペンテニル二リン酸イソメラーゼにおけるフラビン補酵素の機能

邊見　久

新学術領域「生合成マシナリー」第２回若手シンポジウム 

不可逆阻害剤となる基質アナログを用いたタイプ２イソペンテニル二リン酸イソメラーゼの反応機構解析

邊見　久、長井拓也、海野英昭、吉村　徹

日本ビタミン学会第６３回大会 

古細菌イソプレノイド生合成に関わるタイプ２イソペンテニル二リン酸イソメラーゼにおけるフラビン補酵素の特異な機能

邊見　久

日本ビタミン学会第６２回大会 

タイプ２イソペンテニル二リン酸イソメラーゼの反応における還元型FMNの分子触媒機構

邊見　久、長井拓也、海野英昭、吉村　徹

日本ビタミン学会第６２回大会 

Type 2 isopentenyl diphosphate isomerase: unusual reaction mechanism of a flavoenzyme International conference

Italy-Japan Symposium of New Trends in Enzyme Science and Technology 

古細菌膜脂質生合成に関わるフラビン酵素の分子機構解明と応用

邊見　久

第１０回酵素応用シンポジウム 

部位特異的変異導入によるタイプ２イソペンテニル二リン酸イソメラーゼの反応機構解析

邊見　久、長井拓也、海野英昭、吉村　徹

日本ビタミン学会第６１回大会 

The reaction mechanism of type 2 isopentenyl diphosphate isomerase International conference

TERPNET 2009 9th International Meeting: Biosynthesis and Function of Isoprenoids in Plants, Microorganisms and Parasites 

タイプ２イソペンテニル二リン酸イソメラーゼの反応機構：一般酸塩基触媒としてのフラビンの機能

邊見　久、海野英昭、山下　哲、池田陽介、関口信哉、吉田宜永、吉村　徹、楠木正巳、中山　亨、西野徳三

2009年度日本農芸化学会大会 

タイプ２イソペンテニル二リン酸イソメラーゼの反応機構

邊見　久、海野英昭、山下　哲、池田陽介、関口信哉、吉田宜永、中山　亨、西野徳三、楠木正巳、吉村　徹

第１８回ドリコールおよびイソプレノイド研究会例会 

タイプ２イソペンテニル二リン酸イソメラーゼの結晶構造と予想される反応機構

邊見　久、海野英昭、池田陽介、関口信哉、吉田宜永、中山　亨、西野徳三、楠木正巳、吉村　徹

第６０回日本生物工学会大会 

Geranylgeranyl Reductases Responsible for Archaeal Membrane Lipid Biosynthesis International conference

7th US-Japan Seminar on the Biosynthesis of Natural Products: Enzymology, Structural Biology, and Drug Discovery 

好熱性アーキア由来タイプ２イソペンテニル二リン酸イソメラーゼの結晶構造解析

邊見　久、海野英昭、池田陽介、関口信哉、吉田宜永、中山　亨、西野徳三、楠木正巳、吉村　徹

日本ビタミン学会第６０回大会 

メタゲノムスクリーニングへのGC-enriching MDA法の応用

邊見　久、鳴川晃生、中根修平、吉村　徹

日本農芸化学会２００８年度大会 

好熱性アーキア由来ゲラニルゲラニルレダクターゼの反応特異性解析

邊見　久、村上真通、佐藤　翔、吉村　徹

第１７回ドリコールおよびイソプレノイド研究会例会 

Catalytic Specificity of Membrane Lipid Biosynthetic Gerenylgeranyl Reductase from The Thermoacidophilic Archaeon Sulfolobus acidocaldarius International conference

Gordon Research Conference on Archaea: Ecology, Metabolism & Molecular Biology 

タイプ２イソペンテニル二リン酸イソメラーゼにおける基質および補酵素の結合様式

邊見　久、関口信哉、池田陽介、山下　哲、中山　亨、吉村　徹、西野徳三

日本ビタミン学会第５９回大会 

タイプ２イソペンテニル二リン酸イソメラーゼにおける基質結合残基の探索

邊見　久、関口信哉、池田陽介、山下　哲、中山　亨、西野徳三、吉村　徹

日本農芸化学会２００７年度大会 

Geranylgeranyl reductase responsible for the biosynthesis of archaeal membrane lipids International conference

Hisashi Hemmi, Motomichi Murakami, Kyohei Shibuya, Toru Nakayama, Tokuzo Nishino, Tohru Yoshimura

Japan-Italy Symposium of New Trends in Enzyme Science and Technology 

アーキアの膜脂質生合成に関わるゲラニルゲラニルレダクターゼ

邊見　久、村上真通、渋谷恭平、中山　亨、西野徳三

第１６回ドリコールおよびイソプレノイド研究会例会 

タイプ２イソペンテニル二リン酸イソメラーゼへの部位特異的変異導入

邊見　久、池田陽介、山下　哲、中山　亨、西野　徳三

日本農芸化学会２００６年度大会 

超好熱性アーキアArchaeoglobus fulgidus由来ゲラニルゲラニルレダクターゼ

邊見　久、渋谷恭平、中山　亨、西野徳三

第５７回日本生物工学会大会 

好熱性アーキアのプレニル基還元酵素

邊見　久、渋谷恭平、高橋義洋、西野徳三

第１５回ドリコールおよびイソプレノイド研究会例会 

古細菌膜資質生合成における未知の炭素−炭素結合形成反応の解明

2014.11 - 2017.3

武田科学振興財団ライフサイエンス研究奨励 

Application-oriented research on the biosynthesis of archaeal membrane lipids and their relative compounds

2009.8 - 2012.3

Evaluation of microbial diversity in groundwater using hot springs as access points

2006.11 - 2008.3

Research on archaeal membrane lipids as new functional materials

2006.8 - 2008.3

Search of microorganisms and genes of enzymes valuable for the enhancement of microbial degradation process of garbage wastes

2001.9 - 2004.3

Machinery of condensation reactions between isoprene units that generate the structural variety of isoprenoid

Grant number：17H05437  2017.4 - 2019.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Trials to strengthen bacterial cell membrane by the production of archaeal membrane lipids

Grant number：16K14882  2016.4 - 2018.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

Hemmi Hisashi, MOTOYAMA Kento, KOKUBO Takuya, YOSHIDA Ryo

非メバロン酸経路中間体を基質とするプレニル基転移酵素の探索と高分子合成への応用

2014.4 - 2016.3

科学研究費補助金  挑戦的萌芽研究

新奇アーキア酵素を活用した非天然イソプレノイドの生合成マシナリー

2013.4 - 2015.3

科学研究費補助金  新学術領域研究

代謝工学利用を目指したアーキア由来新奇メバロン酸経路の解明

2011.4 - 2014.3

科学研究費補助金  基盤研究(C)

生合成マシナリーヘのアーキア酵素組み込みによる非天然イソプレノイド化合物の創出

2011.4 - 2013.3

科学研究費補助金  新学術領域研究

New developments in isoprenoid metabolism study from archaea

2008.9 - 2010.3

Grant-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists(B)

Isoprenoid lipid metabolism in archaea--from the viewpoint of redox reaction--

2006.9 - 2008.3

Grant-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists(B)

Elucidation of the molecular evolution pathways of prenyltransferases

2002.9 - 2004.3

Grant-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists(B)

長鎖プレニル二燐酸合成酵素

大沼信一、広岡和丈、邊見　久、浅田千佳、大音　徳、西野徳三