Updated on 2022/04/25

写真a

 
HEMMI Hisashi
 
Organization
Graduate School of Bioagricultural Sciences Department of Applied Biosciences Professor
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences
Title
Professor

Degree 1

  1. Doctor of Engineering ( 1998.3   Tohoku University ) 

Research Interests 5

  1. molecular evolution

  2. lipid

  3. enzyme

  4. isoprenoid

  5. archaea

Research Areas 5

  1. Others / Others  / Applied Microbiology

  2. Others / Others  / Applied Biochemistry

  3. Others / Others  / Bio-Function/Bioprocesses

  4. Others / Others  / Functional Biochemistry

  5. Others / Others  / Structural Biochemistry

Current Research Project and SDGs 2

  1. 環境からの有用酵素遺伝子探索技術の開発

  2. イソプレノイド生合成酵素の探索、機能解析、機能改変

Research History 4

  1. Associate Professor, Graduate School of Bioagricultural Sciences, Nagoya University

    2007.4

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    Country:Japan

  2. Associate Professor, Graduate School of Bioagricultural Sciences, Nagoya University

    2005.8 - 2007.3

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    Country:Japan

  3. Visiting scientist, University of Nebraska-Lincoln, USA

    2004.9 - 2005.6

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    Country:Japan

  4. Research Associate, Graduate School of Engineering, Tohoku University

    1998.4 - 2005.7

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    Country:Japan

Education 3

  1. Tohoku University   Graduate School, Division of Engineering   Department of Biomolecular Engineering

    1995.4 - 1998.3

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    Country: Japan

  2. Tohoku University   Graduate School, Division of Engineering   Department of Biomolecular Engineering

    1993.4 - 1995.3

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    Country: Japan

  3. Tohoku University   Faculty of Engineering

    1989.4 - 1993.3

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    Country: Japan

Professional Memberships 9

  1. Japan Society for Bioscience, Biotechnology, and Agrochemistry

    2020.6 - 2022.5

  2. The Society for Biotechnology, Japan

    2007.6 - 2011.5

  3. The Vitamin Society of Japan

    2013.11

  4. The Japanese Biochemical Society

    2010.10 - 2012.9

  5. イソプレノイド研究会

  6. 日本Archaea研究会   幹事

    2015.7

  7. 極限環境生物学会

  8. American Society for Microbiology

  9. American Society for Biochemistry and Molecular Biology

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Committee Memberships 10

  1. 第31回イソプレノイド研究会例会実行委員会   実行委員長  

    2021.9   

  2. 日本ビタミン学会第72回大会実行委員会   委員  

    2020.9   

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    Committee type:Academic society

  3. 日本農芸化学会2018年度大会実行委員会   委員  

    2018.3   

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    Committee type:Academic society

  4. Italy-Japan Symposium New Trends in Enzyme Science and Engineering of Enzyme and Microbiology for Sustainable Society Organizing Committee   Organizing committee member, organizing secretariat  

    2014.11   

  5. 農芸化学会中部支部第168回例会実行委員会   世話人  

    2013.10   

  6. 第20回ドリコールおよびイソプレノイド研究会例会実行委員会   実行委員長  

    2010.10   

  7. Italy-Japan Symposium New Trends in Enzyme Science and Technology Organizing Committee   Committee member  

    2009.10   

  8. 第61回日本生物工学会大会実行委員会   委員  

    2009.9   

  9. 日本農芸化学会2008年度大会実行委員会   委員  

    2008.3   

  10. Japan-Italy Symposium of New Trends in Enzyme Science and Technology Organizing Committee   Committee member  

    2006.11   

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Awards 3

  1. 長瀬研究振興賞

    2019.4   長瀬科学技術振興財団  

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    Award type:Award from publisher, newspaper, foundation, etc.  Country:Japan

  2. 日本ビタミン学会奨励賞

    2010.6   日本ビタミン学会  

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    Country:Japan

  3. 酵素応用シンポジウム研究奨励賞

    2009.6   酵素応用シンポジウム事務局  

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    Country:Japan

 

Papers 116

  1. Identification and characterization of a serine racemase in the silkworm Bombyx mori. Reviewed

    Tanaka Y, Yoshimura T, Hakamata M, Saito C, Sumitani M, Sezutsu H, Hemmi H, Ito T

    Journal of Biochemistry     2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jb/mvac026

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  2. Mechanism of Pyridoxine 5'-Phosphate Accumulation in Pyridoxal 5'-Phosphate-Binding Protein Deficiency. Reviewed

    Ito T, Ogawa H, Hemmi H, Downs DM, Yoshimura T

    Journal of Bacteriology   Vol. 204 ( 3 ) page: e0052121   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JB.00521-21

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  3. Identification and functional analysis of a new type of Z,E-mixed prenyl reductase from mycobacteria. Reviewed

    Abe T, Hakamata M, Nishiyama A, Tateishi Y, Matsumoto S, Hemmi H, Ueda D, Sato T

    The FEBS journal     2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/febs.16412

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  4. Identification and biochemical characterization of a heteromeric cis-prenyltransferase from the thermophilic archaeon Archaeoglobus fulgidus. Reviewed

    Sompiyachoke K, Nagasaka A, Ito T, Hemmi H

    Journal of Biochemistry     2022.2

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jb/mvac022

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  5. Isopentenyl diphosphate/dimethylallyl diphosphate-specific Nudix hydrolase from the methanogenic archaeon Methanosarcina mazei. Reviewed

    Ishibashi Y, Matsushima N, Ito T, Hemmi H

    Bioscience, Biotechnology, and Biochemistry   Vol. 86 ( 2 ) page: 246 - 253   2022.1

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/bbb/zbab205

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  6. Evolution and properties of alanine racemase from Synechocystis sp. PCC6803 Reviewed

    Ashida Hiroyuki, Murakami Kaho, Inagaki Kenji, Sawa Yoshihiro, Hemmi Hisashi, Iwasaki Yugo, Yoshimura Tohru

    JOURNAL OF BIOCHEMISTRY     2021.12

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  7. Enzymatic determination of d-alanine with l-alanine dehydrogenase and alanine racemase Reviewed

    Ashida Hiroyuki, Sawa Yoshihiro, Yoshimura Tohru

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 85 ( 11 ) page: 2221 - 2223   2021.11

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    Language:English  

    DOI: 10.1093/bbb/zbab148

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  8. Total Synthesis and Structure Confirmation of trans-Anhydromevalonate-5-phosphate, a Key Biosynthetic Intermediate of the Archaeal Mevalonate Pathway Reviewed

    Yasuno Yoko, Nakayama Atsushi, Saito Kai, Kitsuwa Kohei, Okamura Hironori, Komeyama Mutsumi, Hemmi Hisashi, Shinada Tetsuro

    JOURNAL OF NATURAL PRODUCTS   Vol. 84 ( 10 ) page: 2749 - 2754   2021.10

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  9. Urinary l-erythro-β-hydroxyasparagine-a novel serine racemase inhibitor and substrate of the Zn2+-dependent d-serine dehydratase. Reviewed

    Ito T, Tono M, Kitaura Y, Hemmi H, Yoshimura T

    Bioscience reports   Vol. 41 ( 4 )   2021.4

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    Language:English  

    DOI: 10.1042/BSR20210260

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  10. A versatile cis-prenyltransferase from Methanosarcina mazei catalyzes both C- and O-prenylations Reviewed

    Okada Miyako, Unno Hideaki, Emi Koh-Ichi, Matsumoto Mayuko, Hemmi Hisashi

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 296   page: 100679   2021.4

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbc.2021.100679

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  11. 古細菌型メバロン酸経路の発見 Invited Reviewed

    邊見 久

    生化学   Vol. 93 ( 2 ) page: 221 - 224   2021.4

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese  

  12. Mechanism of eukaryotic serine racemase-catalyzed serine dehydration Reviewed

    Ito Tomokazu, Matsuoka Mai, Goto Masaru, Watanabe Soichiro, Mizobuchi Taichi, Matsushita Kazuma, Nasu Ryoma, Hemmi Hisashi, Yoshimura Tohru

    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS   Vol. 1868 ( 9 ) page: 140460   2020.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbapap.2020.140460

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  13. Reconstruction of the "Archaeal" Mevalonate Pathway from the Methanogenic Archaeon Methanosarcina mazei in Escherichia coli Cells Reviewed

    Yoshida Ryo, Yoshimura Tohru, Hemmi Hisashi

    APPLIED AND ENVIRONMENTAL MICROBIOLOGY   Vol. 86 ( 6 )   2020.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/AEM.02889-19

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  14. Inhibition of glycine cleavage system by pyridoxine 5 '-phosphate causes synthetic lethality in glyA yggS and serA yggS in Escherichia coli Reviewed International coauthorship

    Ito Tomokazu, Hori Ran, Hemmi Hisashi, Downs Diana M., Yoshimura Tohru

    MOLECULAR MICROBIOLOGY   Vol. 113 ( 1 ) page: 270 - 284   2020.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/mmi.14415

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  15. Construction of an artificial biosynthetic pathway for hyperextended archaeal membrane lipids in the bacterium <i>Escherichia coli</i>. Reviewed

    Yoshida R, Hemmi H

    Synthetic biology (Oxford, England)   Vol. 5 ( 1 ) page: ysaa018   2020

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/synbio/ysaa018

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  16. A heteromeric cis-prenyltransferase is responsible for the biosynthesis of glycosyl carrier lipids in Methanosarcina mazei Reviewed

    Emi Koh-ichi, Sompiyachoke Kitty, Okada Miyako, Hemmi Hisashi

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 520 ( 2 ) page: 291 - 296   2019.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2019.09.143

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  17. Conserved Pyridoxal 5 '-Phosphate-Binding Protein YggS Impacts Amino Acid Metabolism through Pyridoxine 5 '-Phosphate in Escherichia coli Reviewed International coauthorship

    Ito Tomokazu, Yamamoto Kana, Hori Ran, Yamauchi Ayako, Downs Diana M., Hemmi Hisashi, Yoshimura Tohru

    APPLIED AND ENVIRONMENTAL MICROBIOLOGY   Vol. 85 ( 11 )   2019.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/AEM.00430-19

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  18. Conversion of Mevalonate 3-Kinase into 5-Phosphomevalonate 3-Kinase by Single Amino Acid Mutations Reviewed

    Motoyama Kento, Sobue Fumiaki, Kawaide Hiroshi, Yoshimura Tohru, Hemmi Hisashi

    APPLIED AND ENVIRONMENTAL MICROBIOLOGY   Vol. 85 ( 9 )   2019.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/AEM.00256-19

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  19. Modified mevalonate pathway of the archaeon <i>Aeropyrum pernix</i> proceeds via <i>trans</i>-anhydromevalonate 5-phosphate. Reviewed

    Hayakawa H, Motoyama K, Sobue F, Ito T, Kawaide H, Yoshimura T, Hemmi H

    Proceedings of the National Academy of Sciences of the United States of America   Vol. 115 ( 40 ) page: 10034-10039   2018.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.1809154115

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  20. D-Serine Metabolism and Its Importance in Development of Dictyostelium discoideum Reviewed

    Ito Tomokazu, Hamauchi Natsuki, Hagi Taisuke, Morohashi Naoya, Hemmi Hisashi, Sato Yukie G., Saito Tamao, Yoshimura Tohru

    FRONTIERS IN MICROBIOLOGY   Vol. 9   page: 784   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fmicb.2018.00784

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  21. Production of Ophthalmic Acid Using Engineered Escherichia coli Reviewed

    Ito Tomokazu, Tokoro Maiko, Hori Ran, Hemmi Hisashi, Yoshimura Tohru

    APPLIED AND ENVIRONMENTAL MICROBIOLOGY   Vol. 84 ( 7 )   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/AEM.02806-17

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  22. Biosynthetic machinery for C-25,C-25-diether archaeal lipids from the hyperthermophilic archaeon Aeropyrum pernix Reviewed

    Yoshida Ryo, Yoshimura Tohru, Hemmi Hisashi

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 497 ( 1 ) page: 87-92   2018.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2018.02.028

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  23. Utilization of an intermediate of the methylerythritol phosphate pathway, (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate, as the prenyl donor substrate for various prenyltransferases Reviewed

    Hayashi Yoshifumi, Ito Tomokazu, Yoshimura Tohru, Hemmi Hisashi

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 82 ( 6 ) page: 993-1002   2018

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/09168451.2017.1398064

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  24. Occurrence of the (2R,3S) -Isomer of 2-Amino-3,4-dihydroxybutanoic Acid in the Mushroom Hypsizygus marmoreus Reviewed

    Ito Tomokazu, Yu Zhuoer, Yoshino Issei, Hirozawa Yurina, Yamamoto Kana, Shinoda Kiyotugu, Watanabe Akira, Hemmi Hisashi, Asada Yasuhiko, Yoshimura Tohru

    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY   Vol. 65 ( 30 ) page: 6131-6139   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.jafc.7b01893

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  25. Identification of enzymes involved in the mevalonate pathway of Flavobacterium johnsoniae Reviewed

    Hayakawa Hajime, Sobue Fumiaki, Motoyama Kento, Yoshimura Tohru, Hemmi Hisashi

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 487 ( 3 ) page: 702-708   2017.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2017.04.120

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  26. A Single Amino Acid Mutation Converts (R)-5-Diphosphomevalonate Decarboxylase into a Kinase Reviewed

    Motoyama Kento, Unno Hideaki, Hattori Ai, Takaoka Tomohiro, Ishikita Hiroshi, Kawaide Hiroshi, Yoshimura Tohru, Hemmi Hisashi

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 292 ( 6 ) page: 2457-2469   2017.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M116.752535

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  27. メバロン酸経路の多様性 Invited

    邊見 久

    バイオサイエンスとインダストリー   Vol. 74 ( 1 ) page: 15-20   2016

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    Authorship:Lead author   Language:Japanese  

  28. 大腸菌をプラットフォームとしたアーキア膜脂質生合成研究 Invited

    邊見 久

    酵素工学ニュース   ( 76 ) page: 11-15   2016

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    Language:Japanese  

  29. A cis-prenyltransferase from Methanosarcina acetivorans catalyzes both head-to-tail and nonhead-to-tail prenyl condensation Reviewed

    Ogawa, T., Emi, K., Koga, K., Yoshimura, T. & Hemmi, H.

    FEBS Journal   Vol. 283   page: 2369-2383   2016

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  30. Ophthalmic acid accumulation in an Escherichia coli mutant lacking the conserved pyridoxal 5'-phosphate-binding protein YggS Reviewed

    Ito, T., Yamauchi, A., Hemmi, H. & Yoshimura, T.

    Journal of Bioscience and Bioengineering   Vol. 122   page: 689-693   2016

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  31. A new member of MocR/GabR-type PLP-binding regulator of D-alanyl-D-alanine ligase in Brevibacillus brevis Reviewed

    Takenaka, T., Ito, T., Miyahara, I., Hemmi, H. & Yoshimura T.

    FEBS Journal   Vol. 282   page: 4201-4217   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/febs.13415

  32. Domain characterization of Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator Reviewed

    Okuda, K., Ito, T., Goto, M., Takenaka, T., Hemmi, H. & Yoshimura T.

    Journal of Biochemistry   Vol. 158 ( 3 ) page: 225-234   2015

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  33. A highly selective biosynthetic pathway to non-natural C50 carotenoids assembled from moderately selective enzymes Reviewed

    Furubayashi, M., Ikezumi, M., Takaichi, S., Maoka, T., Hemmi, H., Ogawa, T., Saito, K., Tobias, A.V. & Umeno, D.

    Nature Communications   Vol. 6   page: 7534   2015

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  34. A phytoene desaturase homolog gene from the methanogenic archaean Methanosarcina acetivorans is responsible for hydroxyarchaeol biosynthesis Reviewed

    Mori, T., Isobe, K., Ogawa, T., Yoshimura, T. & Hemmi, H.

    Biochemical and Biophysical Research Communications   Vol. 466   page: 186-191   2015

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  35. In vivo formation of the protein disulfide bond that enhances the thermostability of diphosphomevalonate decarboxylase, an intracellular enzyme from the hyperthermophilic archaean Sulfolobus solfataricus Reviewed

    Hattori, A., Unno, H., Goda, S., Motoyama, K., Yoshimura, T. & Hemmi, H.

    Journal of Bacteriology   Vol. 197 ( 21 ) page: 3463-3471   2015

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  36. PEGylated D-serine dehydratase as a D-serine reducing agent Reviewed

    Ito, T., Takada, H., Isobe, K., Suzuki, M., Kitaura, Y., Hemmi, H., Matsuda, T. & Yoshimura T.

    Journal of Pharmaceutical and Biomedical Analysis   Vol. 116   page: 34-39   2015

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  37. Role of the aminotransferase domain in Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator Reviewed

    Okuda, K., Kato, S., Ito, T., Shiraki, S., Kawase, Y., Goto, M., Kawashima, S., Hemmi, H., Fukada H. & Yoshimura T.

    Molecular Microbiology   Vol. 95 ( 2 ) page: 245-257   2015

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  38. Reaction mechanism of Zn2+-dependent D-serine dehydratase: role of a conserved tyrosine residue interacting with pyridine ring nitrogen of pyridoxal 5'-phosphate Reviewed

    Ito, T., Matsuoka, M., Koga, K., Hemmi, H. & Yoshimura, T.

    Journal of Biochemistry   Vol. 156   page: 173-180   2014

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  39. A novel geranylgeranyl reductase from the methanogenic archaeon Methanosarcina acetivorans displays unique regiospecificity Reviewed

    Ogawa, T., Isobe, K., Mori, T., Asakawa, S., Yoshimura, T. & Hemmi, H.

    FEBS Journal   Vol. 281   page: 3165-3176   2014

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  40. (R)-mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum Reviewed

    Azami, Y., Hattori, A., Nishimura, H., Kawaide, H., Yoshimura, T. & Hemmi, H.

    Journal of Biological Chemistry   Vol. 289   page: 15957-15967   2014

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  41. Geranylgeranyl reductase and ferredoxin from Methanosarcina acetivorans are required for the synthesis of fully reduced archaeal membrane lipid in Escherichia coli cells Reviewed

    Isobe, K., Ogawa, T., Hirose, K., Yokoi, T., Yoshimura, T. & Hemmi, H.

    Journal of Bacteriology   Vol. 196   page: 417-423   2014

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  42. Conserved pyridoxal protein that regulates Ile nad Val metabolism Reviewed

    Ito, T., Iimori, J., Takayama, S., Moriyama, A., Yamauchi, A., Hemmi, H. & Yoshimura, T.

    Journal of Bacteriology   Vol. 195   page: 5439-5449   2013

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  43. Substrate specificity of undecaprenyl diphosphate synthase from the hyperthermophilic archaeon Aeropyrum pernix Reviewed

    Mori, T., Ogawa, T., Yoshimura, T. & Hemmi, H.

    Biochemical and Biophysical Research Communications   Vol. 436   page: 230-234   2013

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  44. Biochemical evidence supporting the presence of the classical mevalonate pathway in the thermoacidophilic archaeon Sulfolobus solfataricus Reviewed

    Nishimura, H., Azami, Y., Miyagawa, M., Hashimoto, C., Yoshimura, T. & Hemmi, H.

    Journal of Biochemistry   Vol. 153   page: 415-420   2013

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  45. Catalytic mechanism of serine racemase from Dictyostelium discoideum Reviewed

    Ito, T., Maekawa, M., Hayashi, S., Goto, M., Hemmi, H. & Yoshimura, T.

    Amino Acids   Vol. 44   page: 1073-1084   2013

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  46. Substrate-induced change in the quaternary structure of type 2 isopentenyl diphosphate isomerase from Sulfolobus shibatae Reviewed

    Nakatani, H., Goda, S., Unno, H., Nagai, T., Yoshimura, T. & Hemmi, H.

    Journal of Bacteriology   Vol. 194   page: 3216-3224   2012

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  47. Quantitative analyses of the behavior of exogenously added bacteria during an acidulocomposting process Reviewed

    Suematsu, T., Yamashita, S., Hemmi, H., Yoshinari, A., Shimoyama, T., Nakayama, T. & Nishino, T.

    Journal of Bioscience and Bioengineering   Vol. 114   page: 70-72   2012

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    Language:English   Publishing type:Research paper (scientific journal)  

  48. Metal ion dependency of serine rasemase from Dictyostelium discoideum Reviewed

    Ito, T., Murase, H., Maekawa, M., Goto, M., Hayashi, S., Saito, H., Maki, M., Hemmi, H., & Yoshimura, T.

    Amino Acids   Vol. 43   page: 1567-1576   2012

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  49. Role of Zinc Ion for Catalytic Activity in D-Serine Dehydratase from Saccharomyces cerevisiae Reviewed

    Ito, T., Koga, K., Hemmi, H., & Yoshimura, T.

    FEBS Journal.   Vol. 279   page: 612-624   2012

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  50. Archaeal phospholipid biosynthetic pathway reconstructed in Escherichia coli Reviewed

    Yokoi, T., Isobe, K., Yoshimura, T. & Hemmi, H.

    Archaea   Vol. 2012   page: ID 438931   2012

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  51. Lysine racemase from a lactic acid bacterium, Oenococcus oeni: Structural basis of substrate specificity Reviewed

    Kato, S., Hemmi, H. & Yoshimura, T.

    Journal of Biochemistry   Vol. 152   page: 505-508   2012

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  52. Enzymatic assay for D-aspartic acid using D-aspartate oxidase and oxaloacetate decarboxylase Reviewed

    Kato, S., Ikuta, T., Hemmi, H., Takahashi, S., Kera, Y & Yoshimura, T.

    Bioscience, Biotechnology, and Biochemistry   Vol. 76   page: 2150-2152   2012

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  53. Covalent modification of reduced flavin mononucleotide in type-2 isopentenyl diphosphate isomerase by active-site-directed inhibitors Reviewed

    Nagai, T., Unno, H., Janczak, M.W., Yoshimura, T., Poulter, C.D. & Hemmi, H.

    Proceedings of the National Academy of Sciences of the United States of America   Vol. 108   page: 20461-20466   2011

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  54. Simultaneous determination of D-amino acids by the coupling method of D-amino acid oxidase with high-performance liquid chromatography Reviewed

    Kato, S., Kito, Y., Hemmi, H., & Yoshimura, T.

    Journal of Chromatography B   Vol. 111   page: 104-108   2011

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  55. Connected cavity structure enables prenyl elongation across the dimer interface in mutated geranylfarnesyl diphosphate synthase from Methanosarcina mazei Reviewed

    Ogawa, T., Yoshimura, T. & Hemmi, H.

    Biochemical and Biophysical Research Communications   Vol. 409   page: 333-337   2011

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  56. Structure and mutation analysis of archaeal geranylgeranyl reductase Reviewed

    Sasaki, D., Fujihashi, M., Iwata, Y., Murakami, M., Yoshimura, T., Hemmi, H. & Miki, K.

    Journal of Molecular Biology   Vol. 409   page: 543-557   2011

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  57. Alterations in D-amino acid concentrations and microbial community structures during the fermentation of red and white wines

    Kato, S., Ishihara, T., Hemmi, H., Kobayashi, H. & Yoshimura, T.

    Journal of Bioscience and Bioengineering   Vol. 111   page: 104-108   2011

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  58. ユニークなフラビン酵素:タイプ2イソペンテニル二リン酸イソメラーゼ

    邊見 久

    生化学   Vol. 83 ( 4 ) page: 304-307   2011

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  59. 古細菌イソプレノイド生合成に関わるタイプ2イソペンテニル二リン酸イソメラーゼにおけるフラビン補酵素の特異な機能 Invited Reviewed

    邊見 久

    ビタミン   Vol. 85 ( 1 ) page: 1-8   2011

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  60. Bacillus subtilis spore coat protein LipC is a phospholipase B Reviewed

    Masayama, A., Kato, S., Terashima, T., Molgaard, A., Hemmi, H., Yoshimura, T. & Moriyama, R.

    Bioscience, Biotechnology, and Biochemistry   Vol. 74   page: 24-30   2010

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  61. イソプレノイド代謝にみるフラビン補酵素のユニークな機能

    邊見 久

    バイオサイエンスとインダストリー   Vol. 68 ( 6 ) page: 421-423   2010

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    Authorship:Lead author   Language:Japanese  

  62. フラビン酵素の新機能?

    邊見 久

    生物工学会誌   Vol. 88 ( 3 ) page: 122   2010

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  63. アーキアにおける膜脂質生合成 Invited Reviewed

    邊見 久

    化学と生物   Vol. 48 ( 9 ) page: 614-621   2010

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  64. A highly sensitive enzymatic assay for D- and total serine detection using D-serine dehydratase from Saccharomyces cerevisiae Reviewed

    Naka, T., Ito, T., Hemmi, H. & Yoshimura, T.

    Journal of Molecular Catalysis B: Enzymatic   Vol. 67   page: 150-154   2010

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  65. Biochemical analysis of a novel lipolytic enzyme YvdO from Bacillus subtilis 168 Reviewed

    Kato, S., Yoshimura, T., Hemmi, H. & Moriyama, R.

    Bioscience, Biotechnology, and Biochemistry   Vol. 74   page: 701-706   2010

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  66. Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution Reviewed

    Ogawa, T., Yoshimura, T. & Hemmi, H.

    Biochemical and Biophysical Research Communications   Vol. 393   page: 16-20   2010

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  67. Flavin's new role as a general acid-base catalyst with no redox function in type 2 isopentenyl diphosphate isomerase Reviewed

    Unno, H., Yamashita, S., Ikeda, Y., Sekiguchi, S., Yoshida, N., Yoshimura, T., Kusunoki, M., Nakayama, T., Nishino, T. & Hemmi, H.

    Journal of Biological Chemistry   Vol. 284   page: 9160-9167   2009

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  68. Physiological role of carbon dioxide in spore germination of Clostridium perfringens S40 Reviewed

    Kato, S., Masayama, A., Yoshimura, T., Hemmi, H., Tsunoda, H., Kihara, T. & Moriyama, R.

    Journal of Bioscience and Bioengineering   Vol. 108   page: 477-483   2009

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  69. Polymerase chain reaction-denaturing gradient gel electrophoresis analysis of microbial community structure in landfill leachate Reviewed

    Uchida, M., Hatayoshi, H., Syuku-nobe, A., Shimoyama, T., Nakayama, T., Okuwaki, A., Nishino, T. & Hemmi, H.

    Journal of Hazardous Materials   Vol. 164   page: 1503-1508   2009

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  70. Effect of mutagenesis at the region upstream from the G(Q/E) motif of three types of geranylgeranyl diphosphate synthase on product chain-length Reviewed

    Noike, M., Katagiri, T., Nakayama, T., Nishino, T. & Hemmi, H.

    Journal of Bioscience and Bioengineering   Vol. 107   page: 235-239   2009

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  71. The implication of YggT of Escherichia coli in osmotic regulation Reviewed

    Ito, T., Uozumi, N., Nakamura, T., Takayama, S., Matsuda, N., Aiba, H., Hemmi, H. & Yoshimura, T.

    Journal of Bioscience and Bioengineering   Vol. 73   page: 2698-2704   2009

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    DOI: 10.1271/bbb.90558

  72. A novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae Reviewed

    Ito, T., Hemmi, H., Kataoka, K., Mukai, Y. & Yoshimura, T.

    Biochemical Journal   Vol. 409   page: 399-406   2008

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  73. Reaction mechanism of type 2 isopentenyl diphosphate isomerase Invited Reviewed

    Hisashi Hemmi

    Vitamins   Vol. 82 ( 11 ) page: 581-588   2008

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  74. The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction Reviewed

    Noike, M., Katagiri, T., Nakayama, T., Koyama, T., Nishino, T. & Hemmi, H.

    FEBS Journal   Vol. 275   page: 3921-3933   2008

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  75. Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl-donor, not a dead-end product Reviewed

    Sato, S., Murakami, M., Yoshimura, T. & Hemmi, H.

    Journal of Bacteriology   Vol. 190   page: 3923-3929   2008

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  76. Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus Reviewed

    Murakami, M., Shibuya, K., Nakayama, T., Nishino, T., Yoshimura, T., Hemmi, H.

    FEBS Journal   Vol. 274   page: 805-814   2007

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  77. Enzyme assay of D-serine dehydratase from Saccharomyces cerevisiae Reviewed

    Ito, T., Takahashi, K., Naka, T., Hemmi, H. & Yoshimura, T.

    Analytical Biochemistry   Vol. 371   page: 167-172   2007

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  78. Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer Reviewed

    Doukov, T.I., Hemmi, H., Drennan, C.L., Ragsdale, S.W.

    Journal of Biological Chemistry   Vol. 282   page: 6609-6618   2007

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  79. A novel lipolytic enzyme, YcsK (LipC), located in the spore coat of Bacillus subtilis, is involved in spore germination Reviewed

    Masayama, A., Kuwana, R., Takamatsu, H., Hemmi, H., Yoshimura, T., Watabe, K., Moriyama, R.

    Journal of Bacteriology   Vol. 189   page: 2369-2375   2007

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  80. タイプ2イソペンテニル二リン酸イソメラーゼにおけるFMNの役割

    邊見 久、吉村 徹

    ビタミン   Vol. 81 ( 10 ) page: 504-506   2007

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  81. アーキアにおけるイソプレノイド脂質の生合成:生体化合物の進化の歴史は解明可能だろうか?

    邊見 久

    化学と生物   Vol. 45 ( 9 ) page: 596-598   2007

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  82. Total synthesis of geranylgeranylglyceryl phosphate enantiomers: substrates for characterization of 2,3-O-digeranylgeranylglyceryl phosphate synthase Reviewed

    Zhang, H., Shibuya, K., Hemmi, H., Nishino, T. & Prestwich, G.D.

    Organic Letters   Vol. 8   page: 943-946   2006

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  83. Microbacterium natoriense sp. nov., a novel D-aminoacylase-producing bacterium isolated from soil in Natori, Japan Reviewed

    Liu, J., Nakayama, T., Hemmi, H., Asano, Y., Tsuruoka, N., Shimomura, K., Nishijima, M. & Nishino, T.

    International Journal of Systematic and Evolutionary Microbiology   Vol. 55   page: 611-615   2005

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  84. Menaquinone-specific prenyl reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus Reviewed

    Hemmi, H., Takahashi, Y., Shibuya, K., Nakayama, T. & Nishino, T.

    Journal of Bacteriology   Vol. 187   page: 1937-1944   2005

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  85. UDP-glucuronic acid: Anthocyanin glucuronosyltransferase from red daisy (Bellis perennis) flowers enzymology and phylogenetics of a novel glucuronosyltransferase involved in flower pigment biosynthesis Reviewed

    Sawada, S., Suzuki, H., Ichimaida, F., Yamaguchi, M. A., Iwashita, T., Fukui, Y., Hemmi, H., Nishino, T. & Nakayama, T.

    Journal of Biological Chemistry   Vol. 280   page: 899-906   2005

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  86. Microbial diversity in bio-degradation and re-utilization processes of garbage Reviewed

    Haruta, S., Nakayama, T., Nakamura, K., Hemmi, H., Ishii, M., Igarashi, Y. & Nishino, T.

    Journal of Bioscience and Bioengineering   Vol. 99   page: 1-11   2005

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  87. Molecular biological analysis of microflora in a garbage treatment process under thermoacidophilic conditions Reviewed

    Hemmi, H., Shimoyama, T., Nakayama, T., Hoshi, K. & Nishino, T.

    Journal of Bioscience and Bioengineering   Vol. 97   page: 119-126   2004

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  88. Molecular cloning and characterization of a thermostable carboxylesterase from an archaeon, Sulfolobus shibatae DSMZ5389: a non-linear kinetic behavior of a hormone-sensitive lipase family enzyme Reviewed

    Ejima, K., Liu, J., Oshima, Y., Hirooka, K., Shimanuki, S., Hemmi, H., Nakayama, T. & Nishino, T.

    Journal of Bioscience and Bioengineering   Vol. 98   page: 445-451   2004

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  89. (S)-2,3-Di-O-geranylgeranylglyceryl phosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. Molecular cloning and characterization of a membrane-intrinsic prenyltransferase involved in the biosynthesis of archaeal ether-linked membrane lipids Reviewed

    Hemmi, H., Shibuya, K., Takahashi, Y., Nakayama, T. & Nishino, T.

    Journal of Biological Chemistry   Vol. 279   page: 50197-50203   2004

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  90. Catalytic mechanism of type 2 isopentenyl diphosphate:dimethylallyl diphosphate isomerase: verification of a redox role of the flavin cofactor in a reaction with no net redox change Reviewed

    Hemmi, H., Ikeda, Y., Yamashita, S., Nakayama, T. & Nishino, T.

    Biochemical and Biophysical Research Communications   Vol. 322   page: 905-910   2004

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  91. Type 2 isopentenyl diphosphate isomerase from a thermoacidophilic archaeon Sulfolobus shibatae Reviewed

    Yamashita, S., Hemmi, H., Ikeda, Y., Nakayama, T. & Nishino, T.

    European Journal of Biochemistry   Vol. 271   page: 1087-1093   2004

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  92. Acidulocomposting, an accelerated composting process of garbage under thermoacidophilic conditions for prolonged periods Reviewed

    Nishino, T., Nakayama, T., Hemmi, H., Shimoyama, T., Yamashita, S., Akai, M., Kanagawa, T., & Hoshi, K.

    Journal of Environmental Biotechnology   Vol. 3   page: 33-36   2003

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  93. An alternative mechanism of product chain-length determination in type III geranylgeranyl diphosphate synthase Reviewed

    Hemmi, H., Noike, M., Nakayama, T. & Nishino, T.

    European Journal of Biochemistry   Vol. 270   page: 2186-2194   2003

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  94. Fusion-type lycopene β-cyclase from a thermoacidophilic archaeon Sulfolobus solfataricus Reviewed

    Hemmi, H., Ikejiri, S., Nakayama, T. & Nishino, T.

    Biochemical and Biophysical Research Communications   Vol. 305   page: 586-591   2003

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  95. Introduction of the archaebacterial geranylgeranyl pyrophosphate synthase gene into Chlamydomonas reinhardtii chloroplast Reviewed

    Fukusaki, E. I., Nishikawa, T., Kato, K., Shinmyo, A., Hemmi, H., Nishino, T. & Kobayashi, A.

    Journal of Bioscience and Bioengineering   Vol. 95   page: 283-287   2003

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  96. Collagenolytic serine-carboxyl proteinase from Alicyclobacillus sendaiensis strain NTAP-1: Purification, characterization, gene cloning, and heterologous expression Reviewed

    Tsuruoka, N., Nakayama, T., Ashida, M., Hemmi, H., Nakao, M., Minakata, H., Oyama, H., Oda, K. & Nishino, T.

    Applied and Environmental Microbiology   Vol. 69   page: 162-169   2003

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  97. Alicyclobacillus sendaiensis sp nov., a novel acidophilic, slightly thermophilic species isolated from soil in Sendai, Japan Reviewed

    Tsuruoka, N., Isono, Y., Shida, O., Hemmi, H., Nakayama, T. & Nishino, T.

    International Journal of Systematic and Evolutionary Microbiology   Vol. 53   page: 1081-1084   2003

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  98. Altering the substrate chain-length specificity of an α-glucosidase Reviewed

    Noguchi, A., Nakayama, T., Hemmi, H. & Nishino, T.

    Biochemical and Biophysical Research Communications   Vol. 304   page: 684-690   2003

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  99. Deciphering the molecular basis of the broad substrate specificity of α-glucosidase from Bacillus sp SAM1606 Reviewed

    Noguchi, A., Yano, M., Ohshima, Y., Hemmi, H., Inohara-Ochiai, M., Okada, M., Min, K. S., Nakayama, T. & Nishino, T.

    Journal of Biochemistry   Vol. 134   page: 543-550   2003

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  100. Deletion and insertion of a 192-residue peptide in the active-site domain of glycosyl hydrolase family-2 β-galactosidases Reviewed

    Inohara-Ochiai, M., Hasegawa, S., Iguchi, S., Ashikari, T., Shibano, Y., Hemmi, H., Nakayama, T. & Nishino, T.

    Journal of Bioscience and Bioengineering   Vol. 93   page: 575-583   2002

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  101. Novel medium-chain prenyl diphosphate synthase from the thermo acidophilic archaeon Sulfolobus solfataticus Reviewed

    Hemmi, H., Ikejiri, S., Yamashita, S. & Nishino, T.

    Journal of Bacteriology   Vol. 184   page: 615-620   2002

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  102. Novel sugar phosphotransferase system applicable to the efficient labeling of the compounds synthesized via the non-mevalonate pathway in Escherichia coli Reviewed

    Hemmi, H., Yamashita, S., Nakayama, T. & Nishino, T.

    Journal of Bioscience and Bioengineering   Vol. 93   page: 515-518   2002

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  103. Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations Reviewed

    Hemmi, H., Noike, M., Nakayama, T. & Nishino, T.

    Biochemical and Biophysical Research Communications   Vol. 297   page: 1096-1101   2002

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  104. Site-specific mutagenesis at positions 272 and 273 of the Bacillus sp SAM1606 α-glucosidase to screen mutants with altered specificity for oligosaccharide production by transglucosylation Reviewed

    Okada, M., Nakayama, T., Noguchi, A., Yano, M., Hemmi, H., Nishino, T. & Ueda, T.

    Journal of Molecular Catalysis B-Enzymatic   Vol. 16   page: 265-274   2002

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  105. Dramatic changes in the substrate specificities of prenyltransferase by a single amino acid substitution Reviewed

    Maki, Y., Komabayashi, M., Gotoh, Y., Ohya, N., Hemmi, H., Hirooka, K., Nishino, T. & Koyama, T.

    Journal of Molecular Catalysis B-Enzymatic   Vol. 19   page: 431-436   2002

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  106. Cloning, expression, and characterization of cis-polyprenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus acidocaldarius Reviewed

    Hemmi, H., Yamashita, S., Shimoyama, T., Nakayama, T. & Nishino, T.

    Journal of Bacteriology   Vol. 183   page: 401-404   2001

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  107. ホスミドマイシンー抗マラリア薬としての再発見

    邊見 久

    生物工学会誌   Vol. 78 ( 8 ) page: 338   2000

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  108. Zinc biosorption by a zinc-resistant bacterium, Brevibacterium sp strain HZM-1 Reviewed

    Taniguchi, J., Hemmi, H., Tanahashi, K., Amano, N., Nakayama, T. & Nishino, T.

    Applied Microbiology and Biotechnology   Vol. 54   page: 581-588   2000

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  109. An active-site mutation causes enhanced reactivity and altered regiospecificity of transglucosylation catalyzed by the Bacillus sp SAM1606 α-glucosidase Reviewed

    Inohara-Ochiai, M., Okada, M., Nakayama, T., Hemmi, H., Ueda, T., Iwashita, T., Kan, Y., Shibano, Y., Ashikari, T. & Nishino, T.

    Journal of Bioscience and Bioengineering   Vol. 89   page: 431-437   2000

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  110. The role of histidine-114 of Sulfolobus acidocaldarius geranylgeranyl diphosphate synthase in chain-length determination Reviewed

    Hirooka, K., Kato, T., Matsu-ura, J., Hemmi, H. & Nishino, T.

    FEBS Letters   Vol. 481   page: 68-72   2000

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  111. Identification of genes affecting lycopene formation in Escherichia coli transformed with carotenoid biosynthetic genes: Candidates for early genes in isoprenoid biosynthesis Reviewed

    Hemmi, H., Ohnuma, S., Nagaoka, K. & Nishino, T.

    Journal of Biochemistry   Vol. 123   page: 1088-1096   1998

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  112. Overexpression of an archaeal geranylgeranyl diphosphate synthase in Escherichia coli cells Reviewed

    Ohto, C., Nakane, H., Hemmi, H., Ohnuma, S., Obata, S. & Nishino, T.

    Bioscience Biotechnology and Biochemistry   Vol. 62   page: 1243-1246   1998

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  113. Recognition of allylic substrates in Sulfolobus acidocaldarius geranylgeranyl diphosphate synthase: Analysis using mutated enzymes and artificial allylic substrates Reviewed

    Ohnuma, S., Hemmi, H., Koyama, T., Ogura, K. & Nishino, T.

    Journal of Biochemistry   Vol. 123   page: 1036-1040   1998

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  114. Effects of random mutagenesis in a putative substrate-binding domain of geranylgeranyl diphosphate synthase upon intermediate formation and substrate specificity Reviewed

    Ohnuma, S., Hemmi, H., Ohto, C., Nakane, H. & Nishino, T.

    Journal of Biochemistry   Vol. 121   page: 696-704   1997

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  115. Conversion from farnesyl diphosphate synthase to geranylgeranyl diphosphate synthase by random chemical mutagenesis Reviewed

    Ohnuma, S. I., Nakazawa, T., Hemmi, H., Hallberg, A. M., Koyama, T., Ogura, K. & Nishino, T.

    Journal of Biological Chemistry   Vol. 271   page: 10087-10095   1996

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  116. Conversion of product specificity of archaebacterial geranylgeranyl-diphosphate synthase - Identification of essential amino acid residues for chain length determination of prenyltransferase reaction Reviewed

    Ohnuma, S., Hirooka, K., Hemmi, H., Ishida, C., Ohto, C. & Nishino, T.

    Journal of Biological Chemistry   Vol. 271   page: 18831-18837   1996

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▼display all

Books 5

  1. ビタミン・バイオファクター総合事典

    邊見 久( Role: Contributor ,  2.2.2 ビタミンB2 構造・化学)

    朝倉書店  2021.6 

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    Language:Japanese Book type:Dictionary, encyclopedia

  2. 生体膜の分子機構:リピッドワールドが先導する生命科学

    邊見 久( Role: Joint author)

    化学同人  2014 

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    Language:Japanese

  3. Handbook of Flavoproteins

    Hisashi Hemmi( Role: Joint author)

    Walter de Gruyter  2012 

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    Language:English

  4. Comprehensive Natural Products II Chemistry and Biology

    Kuzuyama, T., Hemmi, H. & Takahashi, S.( Role: Joint author)

    Elsevier  2010 

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    Language:English

  5. 酵素ハンドブック 第3版

    ( Role: Joint author)

    朝倉書店  2008 

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    Language:Japanese

Presentations 63

  1. アーキア型メバロン酸経路の鍵酵素であるホスホメバロン酸脱水酵素は[4Fe-4S]型鉄硫黄クラスターを有する

    米山睦、三野広幸、保野陽子、品田哲郎、伊藤智和、邊見久

    第33回日本Archaea研究会講演会  2021.7.16 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  2. 未培養真正細菌に存在する古細菌型メバロン酸経路

    邊見 久, Riko Kuriki, 吉田 稜

    第30回イソプレノイド研究会例会 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  3. アーキア膜脂質:生合成研究とエンジニアリングへの展開 Invited

    邊見 久

    2019年度卓越大学院GTR成果報告会 

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    Event date: 2020.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋大学理学部坂田・平田ホール   Country:Japan  

  4. 「緩い」基質認識が可能にするプレニル基転移反応のリデザイン Invited

    邊見 久

    生合成リデザイン第7回公開シンポジウム 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:北里大学白金プラチナタワー   Country:Japan  

  5. 超好熱性アーキアAeropyrum pernix由来ホスホ-trans-アンヒドロメバロン酸デカルボキシラーゼの特性評価

    邊見 久, 松嶋夏海, 品田哲郎, 吉村 徹

    第20回極限環境生物学会年会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  6. Discovery of a 'fourth' mevalonate pathway from the hyperthermophilic archaeon Aeropyrum pernix Invited International conference

    Hisashi Hemmi

    Thermophiles 2019 15th International Congress on Thermophiles 

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    Event date: 2019.9

    Language:English   Presentation type:Oral presentation (keynote)  

    Country:Japan  

  7. 超好熱アーキアに見出した「第4の」メバロン酸経路 Invited

    邊見 久

    微生物ウィーク2019 シンポジウム「好熱菌研究最前線」 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  8. 古細菌型メバロン酸経路の発見 Invited

    邊見 久

    2019年度日本農芸化学会大会 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  9. Creation of mevalonate decarboxylase for the production of a second-generation biofuel, isoprenol Invited

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    Event date: 2018.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  10. 超好熱性アーキアから見出された新奇な変形メバロン酸経路

    邊見 久, 早川 祝, 本山 賢人, 祖父江史明, 川出 洋, 吉村 徹

    第91回日本生化学会大会 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  11. A novel modified mevalonate pathway identified from a hyperthemophilic archaeon Aeropyrum pernix International conference

    Hisashi Hemmi, Hajime Hayakawa, Kento Motoyama, Fumiaki Sobue, Tomokazu Ito, Hiroshi Kawaide, and Tohru Yoshimura

    Extremophiles 2018: 12th International Congress of Extremophiles 

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    Event date: 2018.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Italy  

  12. RIトレーサー実験による古細菌メバロン酸経路の解明 Invited

    邊見 久

    第42回国立大学ラジオアイソトープ総合センター長会議 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  13. アーキアにおけるメバロン酸経路の多様性 Invited

    邊見 久

    第12回日本ゲノム微生物学会シンポジウム「アーキアのゲノムバイオロジー〜ゲノム研究が解き明かす新しいアーキアの姿〜」 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  14. 古細菌の耐熱性と膜脂質の関係 Invited

    邊見 久

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  15. Diversity and evolution of the mevalonate pathways in archaea Invited International conference

    Hisashi Hemmi, Kento Motoyama, Ai Hattori, Hideaki Unno, Hiroshi Kawaide, Tohru Yoshimura

    Japan-Italy Joint Symposium: New Trends in Enzyme and Microbial Science in the Translational Biology Era 

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    Event date: 2017.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:National Research Council of Italy, Naples   Country:Italy  

  16. Mutation-induced conversion of diphosphomevalonate decarboxylase into a kinase International conference

    Hisashi Hemmi, Kento Motoyama, Hiroshi Kawaide and Tohru Yoshimura

    TERPNET 2017 13th International Meeting on Biosynthesis, Function and Synthetic Biology of Isoprenoids 

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    Event date: 2017.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Dalian International Conference Centre   Country:China  

  17. 部位特異的変異導入による好熱性古細菌由来メバロン酸3-キナーゼの基質特異性および触媒機能の改変

    本山健人、川出 洋、吉村 徹、邊見 久

    2017年度酵素補酵素研究会 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  18. Evolution of the mevalonate pathways in Archaea International conference

    Hisashi Hemmi

    2nd US-Japan Seminar on the Biosynthesis of Natural Products for Young Researchers 

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    Event date: 2017.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  19. アーキアにおけるメバロン酸経路の多様性とその進化

    邊見 久

    第89回日本生化学会大会 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  20. Conversion of 5-diphosphomevalonate decarboxylase into 3-kinase International conference

    Hisashi Hemmi, Kento Motoyama, Ai Hattori, and Tohru Yoshimura

    The 5th International Conference on Cofactors and Active Enzyme Molecule 2016 

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    Event date: 2016.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  21. 好熱性アーキアSulfolobus solfataricus由来ジホスホメバロン酸デカルボキシラーゼの耐熱性に寄与するサブユニット間ジスルフィド結合

    邊見 久,服部 愛,海野英昭,郷田秀一郎,本山賢人,吉村 徹

    日本Archaea研究会第29回講演会 

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    Event date: 2016.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  22. 分岐型プレニル二リン酸を与えるメタン生成古細菌由来酵素の研究

    邊見 久、小川拓哉、江見晃一、吉村 徹

    2015年度日本農芸化学会中部・関西支部合同大会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  23. メタン生成アーキアのシス型プレニルトランスフェラーゼホモログによる分 岐型プレニル二リン酸の合成

    邊見 久、小川拓哉、吉村 徹

    第25回 イソプレノイド研究会例会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  24. Thermoplasma型変形メバロン酸経路とメバロン酸3-キナーゼ

    邊見 久、生明 靖裕、本山 健人、服部 愛、吉村 徹

    2015年度 酵素補酵素研究会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  25. Thermoplasma-type modified mevalonate pathway and mevalonate 3-kinase International conference

    Hisashi Hemmi, Yasuhiro Azami, Kento Motoyama, Ai Hattori and Tohru Yoshimura

    TERPNET 2015 12th International Meeting on Biosynthesis, Function and Synthetic Biology of Isoprenoids 

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    Event date: 2015.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Canada  

  26. Mevalonate 3-phosphate is an intermediate of the mevalonate pathway in the thermophilic archaeon Thermoplasma acidophilus International conference

    Hisashi Hemmi, Yasuhiro Azami, Ai Hattori, Hiroto Nishimura, Hiroshi Kawaide and Tohru Yoshimura

    Japan-Italy Joint Symposium: New Trends in Science and Engineering of Enzyme and Microbiology for Sustainable Society 

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    Event date: 2014.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  27. Thermoplasma acidophilumより見出された第3のメバロン酸経路

    邊見 久、生明靖裕、服部 愛、西村泰斗、川出 洋、吉村 徹

    日本Archaea研究会第27回講演会 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:立命館大学びわこ・くさつキャンパス   Country:Japan  

  28. 大腸菌をプラットフォームとしたアーキア特異的イソプレノイド脂質の生合成研究

    邊見 久

    2014年度日本農芸化学会大会 

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    Event date: 2014.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:明治大学生田キャンパス   Country:Japan  

  29. A third alternative mevalonate pathway from Thermoplasma acidophilum International conference

    Hisashi Hemmi, Yasuhiro Azami, Ai Hattori, Hiroshi Kawaide and Tohru Yoshimura

    1st US-Japan Seminar on the Biosynthesis of Natural Products for Young Researchers 

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    Event date: 2014.3

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  30. 新規なアプローチによるアーキア膜脂質の生合成研究

    邊見 久

    第86回日本生化学会大会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  31. Biosynthesis of intact archaeal membrane lipid in bacterial cells International conference

    Hisashi Hemmi, Keisuke Isobe, Takeru Yokoi and Tohru Yoshimura

    Gordon Research Conference on Archaea: Ecology, Metabolism & Molecular Biology 

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    Event date: 2013.7 - 2013.8

    Language:English   Presentation type:Poster presentation  

    Country:Italy  

  32. バクテリア細胞中における完全飽和アーキア脂質の生合成 International conference

    邊見 久、磯部圭祐、吉村 徹

    日本Archaea研究会第26回講演会 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  33. アーキア膜脂質生合成に関わる新奇フラビン酵素(1)

    邊見 久、磯部圭祐、吉村 徹

    日本ビタミン学会第65回大会 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  34. タイプ2イソペンテニル二リン酸イソメラーゼにおけるフラビン補酵素の触媒機能

    邊見 久

    2013年度日本農芸化学会大会 

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    Event date: 2013.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  35. Substrate-induced change in the quaternary structure of type 2 isopentenyl diphosphate isomerase from Sulfolobus shibatae

    Hisashi Hemmi

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    Event date: 2012.8

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  36. mechanism-based inhibitorを用いたタイプ2イソペンテニル二リン酸イソメラーゼの反応機構解析

    邊見 久

    2012年度酵素・補酵素研究会 

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    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋大学   Country:Japan  

  37. Archaeal phospholipid biosynthesis pathway reconstructed in E. coli International conference

    Takeru Yokoi, Keisuke Isobe, Tohru Yoshimura and Hisashi Hemmi

    The International Conference of Natural Product Biosynthesis (8th US-Japan Seminar on the Biosynthesis of Natural Products: Enzymology, Structural Biology, Drug Discovery, Genome Mining) 

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    Event date: 2012.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  38. アーキア膜脂質生合成に関わるゲラニルゲラニルレダクターゼの構造機能相関

    邊見 久

    第84回日本生化学会大会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:国立京都国際会館   Country:Japan  

  39. Structure-function relationship in archaeal geranylgeranyl reductase International conference

    Hisashi Hemmi, Yuki Iwata, Daisuke Sasaki, Masahiro Fujihashi, Motomichi Murakami, Tohru Yoshimura, and Kunio Miki

    Gordon Research Conference on Archaea: Ecology, Metabolism & Molecular Biology 

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    Event date: 2011.8 - 2011.9

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  40. Non-redox catalysis by reduced flavin mononucleotide in type 2 isopentenyl diphosphate isomerase International conference

    Hisashi Hemmi

    17th International Symposium on Flavins and Flavoproteins 

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    Event date: 2011.7

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:United States  

  41. タイプ2イソペンテニル二リン酸イソメラーゼにおけるフラビン補酵素の機能

    邊見 久

    新学術領域「生合成マシナリー」第2回若手シンポジウム 

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    Event date: 2011.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:理研鈴木梅太郎ホール、和光市   Country:Japan  

  42. 不可逆阻害剤となる基質アナログを用いたタイプ2イソペンテニル二リン酸イソメラーゼの反応機構解析

    邊見 久、長井拓也、海野英昭、吉村 徹

    日本ビタミン学会第63回大会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島 安田女子大学   Country:Japan  

  43. 古細菌イソプレノイド生合成に関わるタイプ2イソペンテニル二リン酸イソメラーゼにおけるフラビン補酵素の特異な機能

    邊見 久

    日本ビタミン学会第62回大会 

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    Event date: 2010.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  44. タイプ2イソペンテニル二リン酸イソメラーゼの反応における還元型FMNの分子触媒機構

    邊見 久、長井拓也、海野英昭、吉村 徹

    日本ビタミン学会第62回大会 

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    Event date: 2010.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  45. Type 2 isopentenyl diphosphate isomerase: unusual reaction mechanism of a flavoenzyme International conference

    Italy-Japan Symposium of New Trends in Enzyme Science and Technology 

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    Event date: 2009.10

    Language:English   Presentation type:Oral presentation (general)  

  46. 古細菌膜脂質生合成に関わるフラビン酵素の分子機構解明と応用

    邊見 久

    第10回酵素応用シンポジウム 

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    Event date: 2009.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  47. 部位特異的変異導入によるタイプ2イソペンテニル二リン酸イソメラーゼの反応機構解析

    邊見 久、長井拓也、海野英昭、吉村 徹

    日本ビタミン学会第61回大会 

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    Event date: 2009.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  48. The reaction mechanism of type 2 isopentenyl diphosphate isomerase International conference

    TERPNET 2009 9th International Meeting: Biosynthesis and Function of Isoprenoids in Plants, Microorganisms and Parasites 

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    Event date: 2009.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  49. タイプ2イソペンテニル二リン酸イソメラーゼの反応機構:一般酸塩基触媒としてのフラビンの機能

    邊見 久、海野英昭、山下 哲、池田陽介、関口信哉、吉田宜永、吉村 徹、楠木正巳、中山 亨、西野徳三

    2009年度日本農芸化学会大会 

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    Event date: 2009.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  50. タイプ2イソペンテニル二リン酸イソメラーゼの反応機構

    邊見 久、海野英昭、山下 哲、池田陽介、関口信哉、吉田宜永、中山 亨、西野徳三、楠木正巳、吉村 徹

    第18回ドリコールおよびイソプレノイド研究会例会 

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    Event date: 2008.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  51. タイプ2イソペンテニル二リン酸イソメラーゼの結晶構造と予想される反応機構

    邊見 久、海野英昭、池田陽介、関口信哉、吉田宜永、中山 亨、西野徳三、楠木正巳、吉村 徹

    第60回日本生物工学会大会 

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    Event date: 2008.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  52. Geranylgeranyl Reductases Responsible for Archaeal Membrane Lipid Biosynthesis International conference

    7th US-Japan Seminar on the Biosynthesis of Natural Products: Enzymology, Structural Biology, and Drug Discovery 

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    Event date: 2008.6

    Language:English   Presentation type:Oral presentation (general)  

  53. 好熱性アーキア由来タイプ2イソペンテニル二リン酸イソメラーゼの結晶構造解析

    邊見 久、海野英昭、池田陽介、関口信哉、吉田宜永、中山 亨、西野徳三、楠木正巳、吉村 徹

    日本ビタミン学会第60回大会 

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    Event date: 2008.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  54. メタゲノムスクリーニングへのGC-enriching MDA法の応用

    邊見 久、鳴川晃生、中根修平、吉村 徹

    日本農芸化学会2008年度大会 

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    Event date: 2008.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  55. 好熱性アーキア由来ゲラニルゲラニルレダクターゼの反応特異性解析

    邊見 久、村上真通、佐藤 翔、吉村 徹

    第17回ドリコールおよびイソプレノイド研究会例会 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  56. Catalytic Specificity of Membrane Lipid Biosynthetic Gerenylgeranyl Reductase from The Thermoacidophilic Archaeon Sulfolobus acidocaldarius International conference

    Gordon Research Conference on Archaea: Ecology, Metabolism & Molecular Biology 

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    Event date: 2007.8

    Language:English   Presentation type:Poster presentation  

  57. タイプ2イソペンテニル二リン酸イソメラーゼにおける基質および補酵素の結合様式

    邊見 久、関口信哉、池田陽介、山下 哲、中山 亨、吉村 徹、西野徳三

    日本ビタミン学会第59回大会 

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    Event date: 2007.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  58. タイプ2イソペンテニル二リン酸イソメラーゼにおける基質結合残基の探索

    邊見 久、関口信哉、池田陽介、山下 哲、中山 亨、西野徳三、吉村 徹

    日本農芸化学会2007年度大会 

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    Event date: 2007.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  59. Geranylgeranyl reductase responsible for the biosynthesis of archaeal membrane lipids International conference

    Hisashi Hemmi, Motomichi Murakami, Kyohei Shibuya, Toru Nakayama, Tokuzo Nishino, Tohru Yoshimura

    Japan-Italy Symposium of New Trends in Enzyme Science and Technology 

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    Event date: 2006.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

    Hisashi Hemmi, Motomichi Murakami, Kyohei Shibuya, Toru Nakayama, Tokuzo Nishino, Tohru Yoshimura

  60. アーキアの膜脂質生合成に関わるゲラニルゲラニルレダクターゼ

    邊見 久、村上真通、渋谷恭平、中山 亨、西野徳三

    第16回ドリコールおよびイソプレノイド研究会例会 

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    Event date: 2006.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  61. タイプ2イソペンテニル二リン酸イソメラーゼへの部位特異的変異導入

    邊見 久、池田陽介、山下 哲、中山 亨、西野 徳三

    日本農芸化学会2006年度大会 

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    Event date: 2006.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  62. 超好熱性アーキアArchaeoglobus fulgidus由来ゲラニルゲラニルレダクターゼ

    邊見 久、渋谷恭平、中山 亨、西野徳三

    第57回日本生物工学会大会 

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    Event date: 2005.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  63. 好熱性アーキアのプレニル基還元酵素

    邊見 久、渋谷恭平、高橋義洋、西野徳三

    第15回ドリコールおよびイソプレノイド研究会例会 

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    Event date: 2005.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

▼display all

Research Project for Joint Research, Competitive Funding, etc. 9

  1. Microbial production of isoprenoid using the archaeal mevalonate pathway

    2019.4 - 2020.3

    Hisashi Hemmi

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    Grant type:Competitive

  2. 省エネルギー型メバロン酸経路の有用物質生産への応用

    2019.4 - 2020.3

    長瀬科学技術振興財団 2019年度研究助成金 

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    Grant type:Competitive

  3. アーキア膜脂質によるバクテリア膜脂質の置換に基づく大腸菌の細胞膜エンジニアリング

    2018.4 - 2020.3

    発酵研究所平成30年度一般研究助成 

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    Grant type:Competitive

  4. Creation of mevalonate decarboxylase for the production of a second-generation biofuel, isoprenol

    2017.10 - 2018.3

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    Grant type:Competitive

  5. 古細菌膜資質生合成における未知の炭素−炭素結合形成反応の解明

    2014.11 - 2017.3

    武田科学振興財団ライフサイエンス研究奨励 

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    Grant type:Competitive

  6. Application-oriented research on the biosynthesis of archaeal membrane lipids and their relative compounds

    2009.8 - 2012.3

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    Grant type:Competitive

  7. Evaluation of microbial diversity in groundwater using hot springs as access points

    2006.11 - 2008.3

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    Grant type:Competitive

  8. Research on archaeal membrane lipids as new functional materials

    2006.8 - 2008.3

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    Grant type:Competitive

  9. Search of microorganisms and genes of enzymes valuable for the enhancement of microbial degradation process of garbage wastes

    2001.9 - 2004.3

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 12

  1. Creation of microbial cells as the innovative chassis for isoprenoid production

    Grant number:20H02899  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator 

    Grant amount:\18070000 ( Direct Cost: \13900000 、 Indirect Cost:\4170000 )

  2. Redesign of prenyltransfer reactions enabled by "permissive" substrate recognition

    Grant number:19H04651  2019.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

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    Authorship:Principal investigator 

    Grant amount:\7670000 ( Direct Cost: \5900000 、 Indirect Cost:\1770000 )

  3. Cellular membrane engineering of Escherichia coli using membrane lipids from hyperthermophilic archaea

    Grant number:18K19170  2018.6 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    Hemmi Hisashi

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    Authorship:Principal investigator 

    Grant amount:\6240000 ( Direct Cost: \4800000 、 Indirect Cost:\1440000 )

    The research was aimed at the establishment of "cell membrane engineering" technology that might enable to change the properties of E. coli membrane by overproducing isoprenoid membrane lipid from a hyperthermophilic archaeon Aeropyrum pernix, which has long hydrocarbon chains. At the same time, we discovered the archaeal mevalonate pathway, which was a novel pathway that supplies biosynthetic precursors for isoprenoid. Thus, we examined the effect of the introduction of the pathway on microbial production of isoprenoid and therefore proved the increase in isoprenoid production when the host was cultivated semi-anaerobically. In addition, we succeeded in synthesizing an unnatural archaeal membrane lipid that has a long hydrocarbon chain by introducing genes from A. pernix and other organisms in combination into E. coli.

  4. Machinery of condensation reactions between isoprene units that generate the structural variety of isoprenoid

    Grant number:17H05437  2017.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

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    Authorship:Principal investigator 

    Grant amount:\7540000 ( Direct Cost: \5800000 、 Indirect Cost:\1740000 )

  5. Trials to strengthen bacterial cell membrane by the production of archaeal membrane lipids

    Grant number:16K14882  2016.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    Hemmi Hisashi, MOTOYAMA Kento, KOKUBO Takuya, YOSHIDA Ryo

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    Authorship:Principal investigator 

    Grant amount:\3770000 ( Direct Cost: \2900000 、 Indirect Cost:\870000 )

    The structures of membrane lipids from archaea are different from those from other organisms, bacteria and eukaryotes. The difference causes the low permeability of membrane composed of archaeal membrane lipids to small molecules such as ions, which is considered to enable archaea to grow under extreme conditions. Thus, we have forced the bacterium Escherichia coli to produce archaeal membrane lipids in order to strengthen its cell membrane. In this study, we introduced a biosynthetic pathway of the precursors of archaeal membrane lipids in E. coli to increase their production levels. And, we elucidated the biosynthetic pathway of membrane lipids specific to a hyperthermophilic archaeon, which are expected to have greater effects on the strengthening of membrane, and constructed the production system of the lipids in E. coli.

  6. 非メバロン酸経路中間体を基質とするプレニル基転移酵素の探索と高分子合成への応用

    2014.4 - 2016.3

    科学研究費補助金  挑戦的萌芽研究

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    Authorship:Principal investigator 

  7. 新奇アーキア酵素を活用した非天然イソプレノイドの生合成マシナリー

    2013.4 - 2015.3

    科学研究費補助金  新学術領域研究

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    Authorship:Principal investigator 

  8. 代謝工学利用を目指したアーキア由来新奇メバロン酸経路の解明

    2011.4 - 2014.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  9. 生合成マシナリーヘのアーキア酵素組み込みによる非天然イソプレノイド化合物の創出

    2011.4 - 2013.3

    科学研究費補助金  新学術領域研究

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    Authorship:Principal investigator 

  10. New developments in isoprenoid metabolism study from archaea

    2008.9 - 2010.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists(B)

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    Authorship:Principal investigator 

  11. Isoprenoid lipid metabolism in archaea--from the viewpoint of redox reaction--

    2006.9 - 2008.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists(B)

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    Authorship:Principal investigator 

  12. Elucidation of the molecular evolution pathways of prenyltransferases

    2002.9 - 2004.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists(B)

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    Authorship:Principal investigator 

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Industrial property rights 6

  1. 新規な亜鉛吸着菌及び該菌を用いた亜鉛を除去・回収する方法

    西野徳三、中山 亨、邊見 久

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    Applicant:科学技術振興事業団

    Application no:特願2000-127333  Date applied:2000.4

    Announcement no:特開2001-299332 

    Country of applicant:Domestic  

  2. Process for the production of prenyl diphosphate using mutants of geranylgeranyl diphosphate synthase

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    Date applied:1998.4

    Patent/Registration no:US5885810  Date registered:1999.3 

    Country of applicant:Foreign country  

  3. Nucleic acid encoding mutant geranylgeranyl diphosphate synthase

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    Date applied:1998.4

    Patent/Registration no:US5882909  Date registered:1999.3 

    Country of applicant:Foreign country  

  4. Long-chain prenyl diphosphate synthase

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    Application no:EP19960113930  Date applied:1996.8

    Patent/Registration no:EP0763542  Date registered:1999.11 

    Country of applicant:Foreign country  

  5. Long-chain prenyl diphosphate synthase

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    Date applied:1996.8

    Patent/Registration no:US5807725  Date registered:1998.9 

    Country of applicant:Foreign country  

  6. 長鎖プレニル二燐酸合成酵素

    大沼信一、広岡和丈、邊見 久、浅田千佳、大音 徳、西野徳三

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    Applicant:トヨタ自動車

    Application no:特願平7-247043  Date applied:1995.9

    Announcement no:特開平9-65878 

    Country of applicant:Domestic  

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Teaching Experience (On-campus) 42

  1. 化学基礎II

    2021

  2. 化学基礎II

    2020

  3. 化学基礎II

    2019

  4. 化学基礎II

    2018

  5. 化学基礎II

    2017

  6. 化学基礎II

    2016

  7. 化学基礎II

    2015

  8. 化学基礎II

    2014

  9. 化学基礎II

    2013

  10. 化学基礎II

    2012

  11. 化学基礎II

    2011

  12. 生命物理化学1

    2019

  13. 生命物理化学1

    2018

  14. 生命物理化学1

    2017

  15. 生命物理化学1

    2016

  16. 生命物理化学1

    2015

  17. 生命物理化学1

    2014

  18. 生命物理化学1

    2013

  19. 生命物理化学1

    2012

  20. 生命物理化学1

    2011

  21. 応用生命科学実験実習

    2021

  22. 応用生命科学実験実習

    2020

  23. 応用生命科学実験実習

    2019

  24. 応用生命科学実験実習

    2018

  25. 応用生命科学実験実習

    2017

  26. 応用生命科学実験実習

    2016

  27. 応用生命科学実験実習

    2015

  28. 応用生命科学実験実習

    2014

  29. 応用生命科学実験実習

    2013

  30. 応用生命科学実験実習

    2012

  31. 応用生命科学実験実習

    2011

  32. 酵素学特論2

    2020

  33. 酵素学特論2

    2019

  34. 酵素学特論2

    2018

  35. 応用生命化学特論

    2017

  36. 応用生命化学特論

    2016

  37. 応用生命化学特論

    2015

  38. 応用生命化学特論

    2014

  39. 応用生命化学特論

    2013

  40. 応用生命化学特論

    2012

  41. 応用生命化学特論

    2011

  42. 応用生命化学特論

    2005

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