Updated on 2025/02/20

写真a

 
MATSUDA, Naoyuki
 
Organization
Graduate School of Medicine Program in Integrated Medicine Development Professor
Disaster Mitigation Research Center Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor
Other name(s)
Department of Emergency & Critical Care Medicine, Nagoya University Graduate School of Medicine
Profile
Specialty: emergency medicine, anesthesiology, intensive care medicine, critical care medicine,disaster medicine, pharmacology

Degree 1

  1. Doctor of Philosophy ( 2001.3   Hokkaido University ) 

Research Interests 8

  1. Emergency Medicine

  2. Pathogenesis and treatment of multiple organ failure

  3. Critical Care Medicine, Intensive Care Medicine

  4. Anesthesiology

  5. ICU Management System with Education System

  6. Emergency Room Management System with Education System

  7. Establishment of a regional severe trauma management system

  8. tele-ICU system

Research Areas 5

  1. Life Science / Emergency medicine  / Emergency Medicine and Critical Care Medicine

  2. Life Science / Anesthesiology  / Anesthesiology

  3. Life Science / Pharmacology  / Pharmacology

  4. Life Science / Infectious disease medicine  / Infection Control

  5. Life Science / Emergency medicine  / Disaster Medicine, CBRNE Medicine,Acute Toxicology

Current Research Project and SDGs 6

  1. Emergency management system construction in Japan

  2. 救急外来および集中治療室における薬剤の適正使用に関する研究と報告

  3. Foundation for in-hospital intensive care education in a closed ICU and high intensity ICU system

  4. Promoting a global understanding of the pathophysiology of sepsis and septic shock

  5. Pathophysiology of Severe Sepsis

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Research History 11

  1. Department of Emergency & Critical Medicine, Nagoya University Graduate School of Medicine   Professor

    2010.2

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    Country:Japan

  2. 名古屋大学減災研究連携センター・教授   教授

    2010.12

  3. 京都大学大学院医学研究科・初期診療・救急医学分野・准教授   准教授

    2007.9 - 2010.1

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    Country:Japan

  4. 富山大学医学部附属病院麻酔科・診療教授   准教授

    2007.1 - 2007.8

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    Country:Japan

  5. 富山大学医学薬学研究部分子医科薬理学講座・准教授   准教授

    2006.2 - 2007.8

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    Country:Japan

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Education 2

  1. Hokkaido University   Graduate School, Division of Medicine   Surgery

    1995.4 - 2001.3

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    Country: Japan

  2. Hokkaido University   Faculty of Medicine   Division of Medicine

    1986.4 - 1993.3

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    Country: Japan

Professional Memberships 33

  1. Global Sepsis Alliance

    2022.4

  2. 日本集中治療医学会   理事

    2014.3

  3. 日本救急医学会   評議員

    2016.4

  4. 日本心臓血管麻酔学会   常任理事

    2023.4

  5. 日本心臓血管麻酔学会   理事

    2013.9 - 2023.3

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Committee Memberships 6

  1. 名古屋大学入学試験実施委員会   委員  

    2010.4   

  2. 名古屋市メディカルコントロール協議会   副委員長/顧問  

    2010.4   

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    Committee type:Municipal

    名古屋市の救急搬送についての適正化を評価し,さらに還元する協議会

  3. 名古屋大学医学部 広報・ホームページ専門委員会   松田直之  

    2014.4   

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    Committee type:Other

  4. 名大病院災害対策専門委員会   委員長  

    2013.4 - 2018.9   

  5. 名大病院救急外来及び救急・内科系集中治療部運営協議会   設立委員長/議長  

    2011.4 - 2018.9   

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Awards 12

  1. Journal of Intensive Care Review of the Year 2023

    2024.3   日本集中治療医学会   Journal of Intensive Care Review of the Year 2023

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    Award type:Honored in official journal of a scientific society, scientific journal 

    日本集中治療医学会の国際誌の原著論文等の査読に対するベストレビューアとしての表彰です。

  2. Journal of Intensive Care Review of the Year 2021

    2022.3   日本集中治療医学会  

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    Award type:Honored in official journal of a scientific society, scientific journal 

    日本集中治療医学会の国際誌の原著論文等の査読に対するベストレビューアとしての表彰です。

  3. 日本麻酔科学会 第28回山村記念賞

    2009.8   日本麻酔科学会  

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    Award type:International academic award (Japan or overseas)  Country:Japan

    敗血症病態における転写因子NF-kBの機能解析

  4. 2009年日本集中治療医学会 優秀論文賞

    2010.3   日本集中治療医学会  

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

    Nuclear factor-κB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis. Crit Care Med 37:2791-2799,2009.

  5. 39th米国集中治療医学会 Annual Scientific Award

    2010.1   米国集中治療医学会  

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    Inhaled TAK1 siRNA Improves Lung Inflammation and Apoptosis by Reduced Transcriptional Activity of NF-kB and AP-1

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Papers 130

  1. Vascular endotheliitis associated with infections: Its pathogenetic role and therapeutic implication Reviewed

    Hattori, Y; Hattori, K; Machida, T; Matsuda, N

    BIOCHEMICAL PHARMACOLOGY   Vol. 197   page: 114909   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bcp.2022.114909

    Web of Science

    PubMed

  2. Efficacy and safety of landiolol, an ultra-short-acting beta 1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): a multicentre, open-label, randomised controlled trial Reviewed

    Kakihana Yasuyuki, Nishida Osamu, Taniguchi Takumi, Okajima Masaki, Morimatsu Hiroshi, Ogura Hiroshi, Yamada Yoshitsugu, Nagano Tetsuji, Morishima Eiichiro, Matsuda Naoyuki

    LANCET RESPIRATORY MEDICINE   Vol. 8 ( 9 ) page: 863 - 872   2020.9

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    Authorship:Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S2213-2600(20)30037-0

    Web of Science

    PubMed

  3. Impact of patient characteristics on the efficacy and safety of landiolol in patients with sepsis-related tachyarrhythmia: Subanalysis of the J-Land 3S randomised controlled study Reviewed

    Matsuda Naoyuki, Nishida Osamu, Taniguchi Takumi, Okajima Masaki, Morimatsu Hiroshi, Ogura Hiroshi, Yamada Yoshitsugu, Nagano Tetsuji, Ichikawa Akira, Kakihana Yasuyuki

    ECLINICALMEDICINE   Vol. 28   page: 100571   2020.11

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.eclinm.2020.100571

    Web of Science

    PubMed

  4. New drug discovery for surviving sepsis from multiple organ failure Reviewed

    Matsuda Naoyuki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 128 ( 3 ) page: S44-S44   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  5. Clinical paper The rCAST score is useful for estimating the neurological prognosis in pediatric patients with post-cardiac arrest syndrome before ICU admission: External validation study using a nationwide prospective registry Reviewed

    Yasuda Yuma, Nishikimi Mitsuaki, Matsui Kota, Numaguchi Atsushi, Nishida Kazuki, Emoto Ryo, Matsui Shigeyuki, Matsuda Naoyuki

    RESUSCITATION   Vol. 168   page: 103 - 109   2021.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.resuscitation.2021.09.025

    Web of Science

    PubMed

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Books 31

  1. Perioperative/postoperative management – ​​Surgical intensive care Q&A –

    Naoyuki Matsuda( Role: Edit)

    2024.11  ( ISBN:978-4-88378-584-1

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    Total pages:236   Responsible for pages:1~236   Language:Japanese Book type:Textbook, survey, introduction

    General Overview
    1. The Mechanism and System of Surgical Intensive Care
    2. Handover and Conferences in the ICU
    3. Proper Use of Antibiotics in the Perioperative Period
    4. Enteral Nutrition Therapy in the Surgical Perioperative Period
    5. Specialized Perspectives in ICU Perioperative Nursing
    6. Rehabilitation in the Surgical Perioperative Period

    Specific Topics
    1. Monitoring in the ICU
    2. Evaluation of Portable X-ray Images
    3. Evaluation of Blood and Biochemical Tests
    4. Management of Medication Routes in the ICU
    5. Tips and Key Points for Postoperative Drain Management
    6. Ventricular Drainage and Intracranial Pressure Management
    7. ICU Bedside Echo (POCUS)
    8. Weaning from Mechanical Ventilation
    9. Graphic Monitoring of Mechanical Ventilation
    10. Use of HFNC and NPPV
    11. Blood Pressure Management and Use of Circulatory Drugs
    12. Essentials of Antiarrhythmic Drugs
    13. Management of Intra-Aortic Balloon Pump (IABP)
    14. Tips and Key Points for ECMO
    15. Introduction and Management of Impella®
    16. Acute Blood Purification Therapy in Acute Kidney Injury
    17. Evaluation and Management of Coagulation and Fibrinolysis in the Perioperative Period
    18. Management of Fluid In-Out Balance in the Perioperative Period
    19. Electrolyte Management
    20. Management of Post-ICU Syndrome
    21. PADIS Approach in Surgical Intensive Care — Pain, Sedation, and Delirium Management —

  2. 改訂第6版 救急診療指針 監修 日本救急医学会 Reviewed

    松田直之( Role: Contributor ,  血液・免疫疾患)

    株式会社 へるす出版  2024.4  ( ISBN:978-4-86719-083-8

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    Total pages:1522   Responsible for pages:482-496   Language:Japanese Book type:Textbook, survey, introduction

  3. 集中治療医学 日本集中治療医学会 編 Reviewed

    松田直之( Role: Joint author ,  受容体とシグナル伝達)

    株式会社 Gakken  2023.5  ( ISBN:978-4-05-510024-3

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    Total pages:424   Responsible for pages:32-46   Language:Japanese Book type:Textbook, survey, introduction

  4. 救急・集中治療アドバンス「敗血症〜感染症と臓器障害への対応〜」

    松田直之( Role: Edit ,  編集および執筆)

    株式会社 中山書店,東京  2023.1  ( ISBN:978-4-521-74336-3

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    Total pages:512   Responsible for pages:1-512   Language:Japanese Book type:Textbook, survey, introduction

    1 章 総論
     1-1 敗血症の歴史(丸藤 哲)
     1-2 感染症の歴史(長友安弘,二木芳人)
     1-3 敗血症の病態生理(平澤博之)
     1-4 感染症における自然免疫(保倉祥太,竹内 理)
    2 章 敗血症と感染症の診断
     2-1 敗血症の定義と診断(吉村旬平,梅村 穣,小倉裕司)
     2-2 感染症疾患の定義と診断(藤田次郎)
     2-3 細菌診断におけるグラム染色(朝野和典,濱口重人)
     2-4 微生物診断における特殊検査(奥田菜緒,笠原 敬)
     2-5 感染症と敗血症のバイオマーカー(志馬伸朗)
    3 章 感染症の管理
    [3-1 総論]
     3-1-1 院内感染で注意するべき微生物(中嶋一彦)
     3-1-2 細菌培養検査/薬剤感受性の適正評価(草野展周)
    3-1-3 ドレーンを用いた感染症管理(小林美奈子)
    [3-2 各論]
     3-2-1 ブドウ球菌属:MSSA,MRSA,MRCNS(山本善裕,兼田磨熙杜)
     3-2-2 エンテロコッカス属(土戸康弘,藤田直久)
     3-2-3 クレブシエラ属(岡 祐介,青木洋介)
     3-2-4 アシネトバクター属(萩原真生,山岸由佳,三鴨廣繁)
     3-2-5 緑膿菌(荒川宜親,伊藤亮太)
     3-2-6 エンテロバクター属(詫間隆博,時松一成)
     3-2-7 大腸菌(西 順一郎)
     3-2-8 結核菌(御手洗 聡)
     3-2-9 肺炎球菌(藤田次郎)
     3-2-10 溶血性レンサ球菌(飯沼由嗣)
     3-2-11 レジオネラ属(宮良高維)
     3-2-12 クロストリジウム属(中村 敦)
     3-2-13 ウイルス感染症:COVID-19 を念頭においた対応(関 雅文)
     3-2-14 深在性真菌症(大森慶太郎)
     3-2-15 ダニ媒介感染症(山岸由佳)
    4 章 ベーシック:敗血症性臓器障害の管理
     4-1 日本版敗血症診療ガイドライン(矢田部智昭,西田 修)
     4-2 モニタリング(水口義規,谷口 巧)
     4-3 鎮痛・鎮静・せん妄・睡眠の管理(鶴田良介,藤田 基)
     4-4 ARDS の病態と管理(松田直之)
     4-5 敗血症性ショックの管理:血管障害と心臓障害(松田直之)
     4-6 急性腎障害の管理(齋藤尚二,丸山彰一)
     4-7 播種性血管内凝固の管理(早川峰司)
     4-8 神経・筋障害の管理:PICS への対応(中西信人,井上茂亮)
     4-9 急性期栄養管理(中村謙介,小谷穣治)
     4-10 電解質/内分泌の管理(江木盛時)
     4-11 臨床工学機器の管理(相嶋一登)
     4-12 早期リハビリテーションの実際(髙橋佑太,高橋哲也)
    5 章 アドバンス:敗血症管理の工夫
     5-1 災害時における感染症と敗血症への対応(高野知憲,山﨑行敬,國島広之)
     5-2 敗血症の早期発見のためのシステム(中川 聡)
     5-3 抗菌薬のTDM の工夫(松元一明)
     5-4 敗血症における神経集中治療(黒田泰弘,河北賢哉)
     5-5 敗血症における人工呼吸管理の工夫(木庭 茂,則末泰博)
     5-6 敗血症におけるβ遮断薬の適正使用法(垣花泰之)
     5-7 敗血症における血液浄化法の工夫(森山和広,西田 修)
     5-8 ステロイド療法の工夫(黒田浩光,升田好樹)
     5-9 経腸栄養管理の工夫(佐藤格夫,沖田光雄,小川史朗)
     5-10 ビタミン投与の評価と検討(矢田部智昭)

  5. 救急・集中治療 「重症感染症のすべて —研修医からの質問302—」

    松田直之( Role: Edit ,  全内容)

    株式会社 総合医学社  2023.1  ( ISBN:978-4-88378-577-3

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    Total pages:360   Responsible for pages:1-360   Language:Japanese Book type:Textbook, survey, introduction

    I.総 論
    重症感染症を考える
    感染症パンデミック
    感染症法の概要について
    輸入感染症
    1類感染症の動向と対策
    2類感染症の動向と対策
    人工呼吸器関連肺炎の動向
    カテーテル関連血流感染症の動向

    II.感染症の診断・治療・病態
    予防接種の基本知識
    感染症の問診で気をつけること
    微生物検査方法
    血液培養検査で気をつけること
    遺伝子検査機器による感染症診断
    重症感染症の病理
    アンチバイオグラムの作成と利用
    敗血症の診断で気をつけること
    敗血症の治療で気をつけること
    感染症における補体活性化
    凝固・線溶系異常で気をつけること
    消毒薬の効果と限界
    抗菌薬の選択とPK/PD

    III.各種感染症の管理
    結 核
    肺非結核性抗酸菌症
    肺炎球菌
    髄膜炎菌
    インフルエンザ菌
    肺炎マイコプラズマ
    レジオネラ
    COVID-19に対する感染防御策
    COVID-19の診断と治療
    インフルエンザウイルス
    MSSAとMRSA
    腸球菌属
    クレブシエラ属
    アシネトバクター属
    緑膿菌
    エンテロバクター科
    大腸菌
    溶血性連鎖球菌
    破傷風菌
    Clostridium difficile
    嫌気性菌
    カンジダ属―侵襲性カンジダ感染症―
    アスペルギルス属
    ムーコル症
    梅 毒
    食中毒
    犬咬傷
    ダニ刺症(ダニ媒介感染症)

    IV.これからの重症感染対策
    地域における感染制御支援
    感染管理教育
    抗菌薬療法への薬剤師からの支援
    感染症管理データベース

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Presentations 15

  1. Organ Injury and Organ Failure in Intensive Care: IL-6 and Procalcitonin Invited

    Naoyuki Matsuda

    2025.3.14 

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    Event date: 2025.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:Hakata, Japan   Country:Japan  

  2. Educational lecture: "The cutting edge of perioperative sepsis managements" Invited

    Naoyuki Matsuda

    The 44th Annual Meeting of The Japan Society for Clinical Anesthesia  2024.11.22  The Japan Society for Clinical Anesthesia

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    Event date: 2024.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:Tokyo   Country:Japan  

    [Introduction] The international definition of sepsis was changed to Sepsis-3 in 2016, and the "sepsis" changed from "systemic inflammation" in infectious diseases to "organ dysfunction". The pathophysiology of systemic inflammation is being elucidated in more detail based on 1) damage-associated molecular patterns (DAMPs) from surgery, trauma, burns, acute pancreatitis, etc., 2) immunodeficiency and DAMPs and pathogen-associated molecular patterns (PAMPs) associated with immune-linked diseases, and 3) PAMPs associated with perioperative infections. This educational lecture aims to summarize infection control and perioperative ecological invasion control as a clinical practice of anesthesiology, based on the molecular interpretation of DAMPs/PAMPs.
    [Content] This is an opportunity to consider systemic management, including perioperative infection control, based on the following nine contents from both clinical and basic perspectives. 1. Sepsis as a second attack on the body, 2. 1. Emergency emergency anesthesia for sepsis, 2. How to reverse septic shock, 3. Categorization of target bacteria, 5. Effective use of perioperative antibiotics and points to note, 6. Anesthesia for emergency surgery with flesh-eating bacteria, 7. Characteristics of bacteria that cannot be disinfected with alcohol, 8. Intensive care management for septic shock, 9. Management of neuromuscular junction in sepsis.

    [Conclusion] The perspective of "bioinvasive control," a theme in anesthesiology, is one of the essences of sepsis treatment. This is an opportunity to thoroughly implement infection control in the management of DAMPs as a bioinvasive treatment for scheduled surgery, and to consider the appropriateness of anesthesia for patients with sepsis in emergency surgery, as well as postoperative intensive care.

  3. Panel discussion: "Measures to deal with emergency demand" Invited

    Naoyuki Matsuda

    2024.11.21 

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    Event date: 2024.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Akita   Country:Japan  

  4. Euro-Japan Forum 2025 Invited International conference

    Naoyuki Matsuda

    Intensiven Care Medicine:Euro-Japan Forum 2025  2025.3.14  Japanese Society of Intensive Care Medicine & European Society of Intensive Care Medicine

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    Event date: 2025.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:WEB   Country:France  

  5. ジョイントシンポジウム 敗血症診療改善のために:敗血症性ショックの治療. Invited

    松田直之

    第52回日本集中治療医学会学術集会  2025.3.16  日本集中治療医学会,日本救急医学会,日本感染症学会

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    Event date: 2025.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:博多   Country:Japan  

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Other research activities 10

  1. 世界敗血症デー9月13日〜敗血症の認知を高める活動〜. 週刊 日本医事新報 5237:60-61, 2024.

    2024.8

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    世界敗血症デー9月13日〜敗血症の認知を高める活動〜. 週刊 日本医事新報 5237:60-61, 2024.

  2. 集中治療タスク・シフト/シェアに関する安全管理指針作成ワーキンググループ. 日本集中治療医学会 集中治療に係るタスク・シフト/シェアに関する安全管理指針. 日集中医誌 31:21-32, 2024.

    2024.4

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    集中治療タスク・シフト/シェアに関する安全管理指針作成ワーキンググループ. 日本集中治療医学会 集中治療に係るタスク・シフト/シェアに関する安全管理指針. 日集中医誌 31:21-32, 2024.

  3. Mechanisms and systems of surgical intensive care.

    2024.12

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    In Japan, surgical intensive care units (SICU) have developed since the late 1980s, primarily for cases in which postoperative recovery in a general ward is difficult, such as after cardiovascular surgery, esophageal surgery, pancreaticoduodenectomy, and radical hysterectomy. The need for SICUs can be broadly categorized into three major management considerations: (1) cases where surgical trauma is significant, (2) cases where preoperative comorbidities are severe, and (3) cases where intraoperative or postoperative complications arise.

    Most surgeries are performed as "elective surgeries," and preoperative management strategies such as smoking cessation, nutritional management, inflammation control (fever pattern, CRP levels), and blood glucose management (HbA1c levels) are implemented to optimize intraoperative and postoperative care. If sudden symptoms such as fever, inflammation, or an unstable increase in CRP are observed, surgery is postponed. Additionally, if HbA1c is high (normal <6.5%), surgery is delayed until blood glucose management stabilizes, with glycated hemoglobin (normal <17%) being used for monitoring. To optimize postoperative recovery, preoperative preparation is crucial, including (1) inflammation management (reducing the effects of intraoperative and postoperative inflammatory responses), (2) diabetes management (minimizing postoperative glucose intolerance), (3) smoking cessation management (reducing intraoperative and postoperative airway inflammation and suppressing excessive sputum production), (4) respiratory function assessment, (5) cardiac function assessment, (6) liver function assessment, and (7) renal function assessment. These factors collectively shape the intraoperative management plan, including anesthesia methods and anesthetic management.

    On the other hand, in cases requiring emergency surgery due to urgent hospital admission, the preoperative condition of the patient varies significantly compared to elective surgeries. Since preoperative preparation may be incomplete, SICUs play a vital role in reassessing the patient's overall condition and providing additional treatment. In addition to physicians, a multidisciplinary team is involved in patient care, including specialized nurses, clinical engineers (for appropriate management of medical devices), physical therapists (for early rehabilitation), pharmacists (for proper management of oral and intravenous medications), dietitians, and administrative assistants.

  4. 講座 救急・集中治療とサイトカイン「Interleukin-6」. 救急・集中治療 36:573-579, 2024.

    2024.10

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    松田直之. 救急・集中治療とサイトカイン「Interleukin-6」. 救急・集中治療 36:573-579, 2024.

  5. 総説 外科系集中治療におけるPADISの考え方―鎮痛・鎮静・せん妄の管理―. 救急・集中治療 36:188-200, 2024.

    2024.10

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    総説 外科系集中治療におけるPADISの考え方―鎮痛・鎮静・せん妄の管理―. 救急・集中治療 36:188-200, 2024.

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KAKENHI (Grants-in-Aid for Scientific Research) 16

  1. Role of potassium channels on septic cardiomyopathy

    Grant number:23K08464  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

  2. Transcriptome analysis and drug discovery in sepsis

    Grant number:23K24432  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator 

    Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )

  3. Sex differences based development of anti-sepsis drug

    Grant number:23K21461  2021.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s) 

  4. Treatment strategy against sepsis induced thrombocytopenia and the associated complement hyperactivation

    Grant number:21K09065  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

  5. Medical innovation using gene therapy of transcriptional factor STAT3 in septic multiple organ dysfunction

    Grant number:19H03757  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Naoyuki Matsuda

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    Authorship:Principal investigator 

    Grant amount:\17290000 ( Direct Cost: \13300000 、 Indirect Cost:\3990000 )

    In septic mouse model (CLP) by cecal ligation and puncture, JAK2 activity and STAT3 activity was increased in time series. Synthetic administration of double-stranded STAT3 decoy oligodeoxynucleotide (ODN) reduced organ damage in major organs including the lungs, liver, kidneys. STAT3 decoy ODN reduced the overproduction of inflammatory cytokines and chemokines in CLP mice, and significantly suppressed the production of inflammatory molecules such as HMGB1 in the lungs and liver. The result clarifies the role of STAT3 in sepsis and suggests the potential usefulness of STAT3 decoy ODN in gene therapy for sepsis.

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Teaching Experience (On-campus) 41

  1. 名古屋大学 医学部医学科 大講堂講義 救急医学

    2024

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    1 総論 救急・集中治療医学
    2 多臓器不全の病態と管理
    3.多発外傷の診断と治療
    7. 急性薬物中毒の診断と治療
    8 救急初期診療ER:診断と治療(1)
    9 救急初期診療ER:診断と治療(2)

  2. 名古屋大学 全学講義 防災減災学「救急医療体制と減災医学」

    2024

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    災害医療の初動体制と災害時医療における未然の予防策の講義

  3. 名古屋大学 全学講義 現代医学入門「救急医療の仕組みと進歩」

    2024

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    救急医学に関する基本事項,救急医療システムについての総論的講義

  4. 名古屋大学 保健学科 講堂講義 救急医療と災害医療

    2024

  5. 名古屋大学 医学部医学科 選択講義 多臓器不全の診断と治療

    2024

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Teaching Experience (Off-campus) 19

  1. Universitas Muhammadiyah Emergency Medicine

    2024.4

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    Level:Undergraduate (liberal arts)  Country:Indonesia

  2. 京都大学医学部医学科 救急医学(大講堂講義・臨床実習)

    2007.4 - 2010.3 Kyoto University)

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    Level:Undergraduate (specialized) 

  3. 京都大学医学部保健学科 リハビリテーション 大講堂講義

    2007.4 - 2010.3 Kyoto University)

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    Level:Undergraduate (specialized)  Country:Japan

  4. 富山大学医学部医学科 麻酔科学 大講堂講義

    2006.4 - 2020.3 University of Toyama)

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    Level:Undergraduate (specialized)  Country:Japan

  5. 富山大学医学部医学科 薬理学 大講堂講義

    2006.4 - 2019.3 University of Toyama)

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    Level:Undergraduate (specialized)  Country:Japan

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Social Contribution 12

  1. World sepsis Day Kyoto 2024

    Role(s):Appearance, Panelist, Commentator, Presenter, Media coverage, Lecturer, Planner, Organizing member, Demonstrator, Contribution

    Naoyuki Matsuda MD, PhD  Kyoto Station  2024.9

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    Audience: Junior students, High school students, College students, Graduate students, Teachers, Researchesrs, General, Scientific, Company, Civic organization, Governmental agency, Media

    Type:Science festival

    In order to raise awareness of sepsis, "World Sepsis Day" was held on September 8, 2024 at Muromachi-koji Square on the 4th floor of Kyoto Station. The total number of participants was about 10,000, of which about 350 were seated in the stepped seating on the floor, making it a large-scale sepsis awareness activity on a global world scale. I was the producer and director of this event.

  2. Sepsis Festival 2019 in NAGOYA

    Role(s):Panelist, Commentator, Presenter, Media coverage, Interviewer, Editer, Lecturer, Informant, Planner, Organizing member, Demonstrator, Contribution

    Naoyuki Matsuda MD, PhD  2019.3 - 2019.4

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    Audience: Infants, Schoolchildren, Junior students, High school students, College students, Graduate students, Teachers, Guardians, Researchesrs, General, Scientific, Company, Civic organization, Governmental agency, Media

    Type:Science festival

  3. Medical support for patients with severe burns after a dust explosion in Taiwan

    Role(s):Panelist, Lecturer, Advisor, Informant, Organizing member, Investigater, Report writing, Contribution

    Japan Medical Association  Taiwan  2015.7 - 2015.11

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    Audience: High school students, College students, Graduate students, Teachers, Guardians, Researchesrs, General, Scientific, Company, Civic organization, Governmental agency, Media

    Type:Investigation, survey

    On June 27th of this year, a dust explosion occurred at a theme park in Taiwan, leaving approximately 500 young people with severe burns. A team of specialist doctors from Japan worked hard to provide treatment using artificial skin and medical supplies donated from Japan.

    In response to a request for emergency medical support from the Taiwan Medical Association and other organizations, the Japan Medical Association dispatched six burn treatment specialists from the Japanese Society of Intensive Care Medicine, the Japanese Society of Emergency Medicine, and the Japanese Burn Association as the Japan Medical Association's "Tri-Society Joint Burn Medical Support Team" from July 12th to 15th. As the leader of this team, he handled medical cooperation, information sharing, health meetings, and interviews.

    The Japan Medical Association held a press conference to announce the following:

    July 15: Emergency medical support for victims of severe burns caused by an explosion accident in Taiwan based on the iJN-France-T initiative

    August 5: Attending the iJN-France-T Agreement Signing Ceremony with the Taiwan Medical Association

    September 9: Report on the activities of the "Hakuhon Medical Association Three-School Joint Burn Treatment Support Team" in the Taiwan Dust Explosion Accident

    October 28: Funding for medical support activities for patients with severe burns caused by an explosion accident in Taiwan

  4. World Sepsis Day in Nagoya and Tokai, Japan

    Role(s):Appearance, Panelist, Commentator, Presenter, Media coverage, Lecturer, Advisor, Informant, Organizing member, Demonstrator, Contribution

    Naoyuki Matsuda project  Interviews, Article postings, CBC Radio, etc.  2012.9

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    Audience: Schoolchildren, Junior students, High school students, College students, Graduate students, Teachers, Guardians, Researchesrs, General, Scientific, Company, Civic organization, Media

    Type:TV or radio program

  5. Global Sepsis Alliance 世界敗血症デー in NAGOYA

    Role(s):Panelist, Commentator, Presenter, Chief editor, Interviewer, Editer, Lecturer, Advisor, Informant, Planner, Organizing member, Demonstrator, Investigater, Report writing

    2011.9

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    Type:Lecture

    敗血症の診療成績を高めるために,Global Sepsis Allianceに所属し,東海地方にGlobal Sepsis Alliance in NAGOYAを設立しました。年1回9月13日を世界敗血症デイとし,世界と連携して東海および日本の敗血症診療キャンペーンを実施しています。「Global Sepsis Alliance in NAGOYA」の代表として,感染症診療の適正化に向けた国際連携を展開しています。

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Media Coverage 3

  1. 世界と連携した集中治療教育 TV or radio program

    松田直之  2007.1

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    集中治療の教育活動を,講演,メディア,誌上掲載などの方策として,世界と連携して行っています。

  2. 救急医療を知るための会 TV or radio program

    松田直之  2005.4

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    救急医療のすべてについて,仕組み作り,重要な管理内容,救急医療の詳細等について,講演,実演,アドバイスなどを,日本救急医学会指導医・専門医として広く行っています。

  3. 敗血症という病態を知っていただくための会

    1998.4

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    敗血症について,医療従事者のみではなく,広く市民の皆さまに情報提供しています。

Academic Activities 3

  1. World Sepsis Day Kyoto 2024 International contribution

    Role(s):Planning, management, etc., Panel moderator, session chair, etc., Supervision (editorial), Planning/Implementing academic research

    Naoyuki Matsuda  2024.9

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    Type:Competition, symposium, etc. 

  2. 救急医療に関する報道協力 International contribution

    Role(s):Planning, management, etc., Panel moderator, session chair, etc., Supervision (editorial), Review, evaluation, Planning/Implementing academic research, Peer review

    テレビ局・ラジオ局  2000.4

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    Type:Scientific advice/Review 

    救急医療のかかえる現在の課題,そして将来の展望について,さまざまなインタビューに協力し,本邦および世界の救急医療の発展に貢献する方針としています。

  3. Press cooperation on the management of various types of infectious diseases and sepsis

    Role(s):Planning, management, etc., Panel moderator, session chair, etc., Supervision (editorial), Review, evaluation, Planning/Implementing academic research, Peer review

    2010.2

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    Type:Scientific advice/Review 

    Many understandings about the management of infectious diseases and sepsis will be provided to contribute Japan and the world.