Updated on 2025/02/03

写真a

 
MATSUDA, Naoyuki
 
Organization
Graduate School of Medicine Program in Integrated Medicine Development Professor
Disaster Mitigation Research Center Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor
Other name(s)
Department of Emergency & Critical Care Medicine, Nagoya University Graduate School of Medicine
Profile
Specialty: emergency medicine, anesthesiology, intensive care medicine, critical care medicine,disaster medicine, pharmacology

Degree 1

  1. Doctor of Philosophy ( 2001.3   Hokkaido University ) 

Research Interests 8

  1. Emergency Medicine

  2. Pathogenesis and treatment of multiple organ failure

  3. Critical Care Medicine, Intensive Care Medicine

  4. Anesthesiology

  5. Emergency Room Management System with Education System

  6. ICU Management System with Education System

  7. tele-ICU system

  8. Establishment of a regional severe trauma management system

Research Areas 5

  1. Life Science / Emergency medicine  / Emergency Medicine and Critical Care Medicine

  2. Life Science / Anesthesiology  / Anesthesiology

  3. Life Science / Pharmacology  / Pharmacology

  4. Life Science / Infectious disease medicine  / Infection Control

  5. Life Science / Emergency medicine  / Disaster Medicine, CBRNE Medicine,Acute Toxicology

Current Research Project and SDGs 6

  1. Emergency management system construction in Japan

  2. 救急外来および集中治療室における薬剤の適正使用に関する研究と報告

  3. Foundation for in-hospital intensive care education in a closed ICU and high intensity ICU system

  4. Promoting a global understanding of the pathophysiology of sepsis and septic shock

  5. Pathophysiology of Severe Sepsis

  6. Research on cell death in the field of emergency and intensive care: building a theory for cell lifesaving

▼display all

Research History 11

  1. Department of Emergency & Critical Medicine, Nagoya University Graduate School of Medicine   Professor

    2010.2

      More details

    Country:Japan

  2. 名古屋大学減災研究連携センター・教授   教授

    2010.12

  3. 京都大学大学院医学研究科・初期診療・救急医学分野・准教授   准教授

    2007.9 - 2010.1

      More details

    Country:Japan

  4. 富山大学医学部附属病院麻酔科・診療教授   准教授

    2007.1 - 2007.8

      More details

    Country:Japan

  5. 富山大学医学薬学研究部分子医科薬理学講座・准教授   准教授

    2006.2 - 2007.8

      More details

    Country:Japan

  6. 北海道大学大学院医学研究科・救急医学分野・学内講師

    2004.4 - 2006.1

      More details

    Country:Japan

  7. 北海道大学病院 救急部・集中治療部・助手

    2000.10 - 2004.3

      More details

    Country:Japan

  8. 北海道大学医学部附属病院 救急部・集中治療部・医員

    2000.4 - 2000.9

      More details

    Country:Japan

  9. Hokkaido University

    1995.4 - 2000.3

  10. 北海道砂川市立病院・医員

    1994.4 - 1995.3

      More details

    Country:Japan

  11. 北海道大学医学部附属病院・医員

    1993.4 - 1994.3

      More details

    Country:Japan

▼display all

Education 2

  1. Hokkaido University   Graduate School, Division of Medicine   Surgery

    1995.4 - 2001.3

      More details

    Country: Japan

  2. Hokkaido University   Faculty of Medicine   Division of Medicine

    1986.4 - 1993.3

      More details

    Country: Japan

Professional Memberships 33

  1. Global Sepsis Alliance

    2022.4

  2. 日本集中治療医学会   理事

    2014.3

  3. 日本救急医学会   評議員

    2016.4

  4. 日本心臓血管麻酔学会   常任理事

    2023.4

  5. 日本心臓血管麻酔学会   理事

    2013.9 - 2023.3

  6. 日本救急医学会中部地方会誌   編集委員長

    2024.4

  7. 日本麻酔学会   代議員

    2024.4

  8. 日本心臓血管麻酔学会   集中治療部会・委員長

    2015.4

  9. Journal of Cardiothoracic and Vascular Anesthesia   Editorial Board

    2010.4

  10. 日本集中治療医学会   集中治療薬剤委員会・委員長

    2021.4 - 2023.3

  11. 日本集中治療医学会   広報委員会・委員長

    2014.4 - 2023.3

  12. 日本集中治療医学会   Global Sepsis Alliance委員会・担当理事

    2019.1

  13. 日本救急医学会中部地方会   理事

    2011.4

  14. 日本臨床麻酔学会   評議員

    2010.4

  15. 日本感染症学会

  16. 日本化学療法学会

  17. 日本外傷学会

  18. 日本呼吸器学会

  19. 日本薬理学会   評議員

    2005.4 - 2006.3

  20. 日本炎症・再生医学会

  21. 日本ペインクリニック学会

  22. Japanese Society of Intensive Care Medicine   Chairman of International Committee

    2013.4 - 2017.3

  23. 日本心臓血管麻酔学会   編集委員長

    2011.4 - 2016.3

  24. 日本集中治療医学会   専門医委員会 委員

    2010.4 - 2011.3

  25. 日本臨床麻酔学会   査読委員

    2007.4

  26. 日本外科感染症学   医の質・安全委員会 副委員長

    2007.4

  27. 日本循環制御医学会   機関誌編集委員

    2007.4 - 2013.3

  28. the Society of Critical Care Medicine   Internal Medicine Section member

    2007.4 - 2008.3

  29. 日本外科感染症学会誌   編集委員・査読委員

    2006.4 - 2012.3

  30. 日本心臓血管麻酔学会   文献レビュー委員会 委員長

    2006.4 - 2010.3

  31. 日本集中治療医学会   評議員

    2005.4

  32. 日本麻酔科学会   評議員

    2005.4 - 2010.3

  33. American Society of Anesthesiologist

▼display all

Committee Memberships 6

  1. 名古屋大学入学試験実施委員会   委員  

    2010.4   

  2. 名古屋市メディカルコントロール協議会   副委員長/顧問  

    2010.4   

      More details

    Committee type:Municipal

    名古屋市の救急搬送についての適正化を評価し,さらに還元する協議会

  3. 名古屋大学医学部 広報・ホームページ専門委員会   松田直之  

    2014.4   

      More details

    Committee type:Other

  4. 名大病院災害対策専門委員会   委員長  

    2013.4 - 2018.9   

  5. 名大病院救急外来及び救急・内科系集中治療部運営協議会   設立委員長/議長  

    2011.4 - 2018.9   

  6. 名大病院移植検討委員会   委員長  

    2012.4 - 2018.9   

▼display all

Awards 12

  1. Journal of Intensive Care Review of the Year 2023

    2024.3   日本集中治療医学会   Journal of Intensive Care Review of the Year 2023

     More details

    Award type:Honored in official journal of a scientific society, scientific journal 

    日本集中治療医学会の国際誌の原著論文等の査読に対するベストレビューアとしての表彰です。

  2. Journal of Intensive Care Review of the Year 2021

    2022.3   日本集中治療医学会  

     More details

    Award type:Honored in official journal of a scientific society, scientific journal 

    日本集中治療医学会の国際誌の原著論文等の査読に対するベストレビューアとしての表彰です。

  3. 日本麻酔科学会 第28回山村記念賞

    2009.8   日本麻酔科学会  

     More details

    Award type:International academic award (Japan or overseas)  Country:Japan

    敗血症病態における転写因子NF-kBの機能解析

  4. 2009年日本集中治療医学会 優秀論文賞

    2010.3   日本集中治療医学会  

     More details

    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

    Nuclear factor-κB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis. Crit Care Med 37:2791-2799,2009.

  5. 39th米国集中治療医学会 Annual Scientific Award

    2010.1   米国集中治療医学会  

     More details

    Inhaled TAK1 siRNA Improves Lung Inflammation and Apoptosis by Reduced Transcriptional Activity of NF-kB and AP-1

  6. 40th米国集中治療医学会 Reserch Citation Award

    2010.1   米国集中治療医学会  

     More details

    Award type:Award from international society, conference, symposium, etc.  Country:United States

  7. 35th米国集中治療医学会 Reserch Citation Award

    2006.1   米国集中治療医学会  

  8. 2004年日本集中治療医学会 優秀論文賞

    2005.2   日本集中治療医学会  

     More details

    Country:Japan

    Therapeutic effect of in vivo transfection of transcription factor decoy to NF-kB on septic lung in mice. Am J Physiol Lung Cell Mol Physiol 287: L1248-L1255,2004.

  9. 日本ヒスタミン研究会 第1回和田記念賞

    2004.12   日本ヒスタミン研究会  

     More details

    Country:Japan

    敗血症に合併する急性肺障害の増悪機構 ―ヒスタミン受容体発現の変化―

  10. 33th米国集中治療医学会 Annual Scientific Award

    2004.2   米国集中治療医学会  

  11. 日本救急医学会 丸茂賞

    2003.11   日本救急医学会  

     More details

    Country:Japan

  12. 北海道麻酔科学会 第15回高橋賞

    2002.9   北海道麻酔科学会  

     More details

    Country:Japan

▼display all

 

Papers 130

  1. Vascular endotheliitis associated with infections: Its pathogenetic role and therapeutic implication Reviewed

    Hattori, Y; Hattori, K; Machida, T; Matsuda, N

    BIOCHEMICAL PHARMACOLOGY   Vol. 197   page: 114909   2022.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bcp.2022.114909

    Web of Science

    PubMed

  2. Efficacy and safety of landiolol, an ultra-short-acting beta 1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): a multicentre, open-label, randomised controlled trial Reviewed

    Kakihana Yasuyuki, Nishida Osamu, Taniguchi Takumi, Okajima Masaki, Morimatsu Hiroshi, Ogura Hiroshi, Yamada Yoshitsugu, Nagano Tetsuji, Morishima Eiichiro, Matsuda Naoyuki

    LANCET RESPIRATORY MEDICINE   Vol. 8 ( 9 ) page: 863 - 872   2020.9

     More details

    Authorship:Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S2213-2600(20)30037-0

    Web of Science

    PubMed

  3. Impact of patient characteristics on the efficacy and safety of landiolol in patients with sepsis-related tachyarrhythmia: Subanalysis of the J-Land 3S randomised controlled study Reviewed

    Matsuda Naoyuki, Nishida Osamu, Taniguchi Takumi, Okajima Masaki, Morimatsu Hiroshi, Ogura Hiroshi, Yamada Yoshitsugu, Nagano Tetsuji, Ichikawa Akira, Kakihana Yasuyuki

    ECLINICALMEDICINE   Vol. 28   page: 100571   2020.11

     More details

    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.eclinm.2020.100571

    Web of Science

    PubMed

  4. New drug discovery for surviving sepsis from multiple organ failure Reviewed

    Matsuda Naoyuki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 128 ( 3 ) page: S44-S44   2015.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  5. Clinical paper The rCAST score is useful for estimating the neurological prognosis in pediatric patients with post-cardiac arrest syndrome before ICU admission: External validation study using a nationwide prospective registry Reviewed

    Yasuda Yuma, Nishikimi Mitsuaki, Matsui Kota, Numaguchi Atsushi, Nishida Kazuki, Emoto Ryo, Matsui Shigeyuki, Matsuda Naoyuki

    RESUSCITATION   Vol. 168   page: 103 - 109   2021.11

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.resuscitation.2021.09.025

    Web of Science

    PubMed

  6. Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock Reviewed

    Hiraiwa Hiroaki, Kasugai Daisuke, Ozaki Masayuki, Goto Yukari, Jingushi Naruhiro, Higashi Michiko, Nishida Kazuki, Kondo Toru, Furusawa Kenji, Morimoto Ryota, Okumura Takahiro, Matsuda Naoyuki, Matsui Shigeyuki, Murohara Toyoaki

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 18823   2021.9

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-98397-8

    Web of Science

    PubMed

  7. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020). Reviewed

    Egi M, Ogura H, Yatabe T, Atagi K, Inoue S, Iba T, Kakihana Y, Kawasaki T, Kushimoto S, Kuroda Y, Kotani J, Shime N, Taniguchi T, Tsuruta R, Doi K, Doi M, Nakada TA, Nakane M, Fujishima S, Hosokawa N, Masuda Y, Matsushima A, Matsuda N, Yamakawa K, Hara Y, Sakuraya M, Ohshimo S, Aoki Y, Inada M, Umemura Y, Kawai Y, Kondo Y, Saito H, Taito S, Takeda C, Terayama T, Tohira H, Hashimoto H, Hayashida K, Hifumi T, Hirose T, Fukuda T, Fujii T, Miura S, Yasuda H, Abe T, Andoh K, Iida Y, Ishihara T, Ide K, Ito K, Ito Y, Inata Y, Utsunomiya A, Unoki T, Endo K, Ouchi A, Ozaki M, Ono S, Katsura M, Kawaguchi A, Kawamura Y, Kudo D, Kubo K, Kurahashi K, Sakuramoto H, Shimoyama A, Suzuki T, Sekine S, Sekino M, Takahashi N, Takahashi S, Takahashi H, Tagami T, Tajima G, Tatsumi H, Tani M, Tsuchiya A, Tsutsumi Y, Naito T, Nagae M, Nagasawa I, Nakamura K, Nishimura T, Nunomiya S, Norisue Y, Hashimoto S, Hasegawa D, Hatakeyama J, Hara N, Higashibeppu N, Furushima N, Furusono H, Matsuishi Y, Matsuyama T, Minematsu Y, Miyashita R, Miyatake Y, Moriyasu M, Yamada T, Yamada H, Yamamoto R, Yoshida T, Yoshida Y, Yoshimura J, Yotsumoto R, Yonekura H, Wada T, Watanabe E, Aoki M, Asai H, Abe T, Igarashi Y, Iguchi N, Ishikawa M, Ishimaru G, Isokawa S, Itakura R, Imahase H, Imura H, Irinoda T, Uehara K, Ushio N, Umegaki T, Egawa Y, Enomoto Y, Ota K, Ohchi Y, Ohno T, Ohbe H, Oka K, Okada N, Okada Y, Okano H, Okamoto J, Okuda H, Ogura T, Onodera Y, Oyama Y, Kainuma M, Kako E, Kashiura M, Kato H, Kanaya A, Kaneko T, Kanehata K, Kano KI, Kawano H, Kikutani K, Kikuchi H, Kido T, Kimura S, Koami H, Kobashi D, Saiki I, Sakai M, Sakamoto A, Sato T, Shiga Y, Shimoto M, Shimoyama S, Shoko T, Sugawara Y, Sugita A, Suzuki S, Suzuki Y, Suhara T, Sonota K, Takauji S, Takashima K, Takahashi S, Takahashi Y, Takeshita J, Tanaka Y, Tampo A, Tsunoyama T, Tetsuhara K, Tokunaga K, Tomioka Y, Tomita K, Tominaga N, Toyosaki M, Toyoda Y, Naito H, Nagata I, Nagato T, Nakamura Y, Nakamori Y, Nahara I, Naraba H, Narita C, Nishioka N, Nishimura T, Nishiyama K, Nomura T, Haga T, Hagiwara Y, Hashimoto K, Hatachi T, Hamasaki T, Hayashi T, Hayashi M, Hayamizu A, Haraguchi G, Hirano Y, Fujii R, Fujita M, Fujimura N, Funakoshi H, Horiguchi M, Maki J, Masunaga N, Matsumura Y, Mayumi T, Minami K, Miyazaki Y, Miyamoto K, Murata T, Yanai M, Yano T, Yamada K, Yamada N, Yamamoto T, Yoshihiro S, Tanaka H, Nishida O

    Journal of intensive care   Vol. 9 ( 1 ) page: 53   2021.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40560-021-00555-7

    PubMed

  8. Beneficial effect of STAT3 decoy oligodeoxynucleotide transfection on organ injury and mortality in mice with cecal ligation and puncture-induced sepsis Reviewed

    Imbaby Samar, Matsuda Naoyuki, Tomita Kengo, Hattori Kohshi, Palikhe Sailesh, Yokoo Hiroki, Hattori Yuichi

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 15316   2020.9

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-72136-x

    Web of Science

    PubMed

  9. Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU: A Single-Center Randomized Placebo-Controlled Trial Reviewed

    Nishikimi Mitsuaki, Numaguchi Atsushi, Takahashi Kunihiko, Miyagawa Yasuhiro, Matsui Kota, Higashi Michiko, Makishi Go, Matsui Shigeyuki, Matsuda Naoyuki

    CRITICAL CARE MEDICINE   Vol. 46 ( 7 ) page: 1099-1105   2018.7

     More details

    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000003132

    Web of Science

    PubMed

  10. Activator Protein-1 Decoy Oligodeoxynucleotide Transfection Is Beneficial in Reducing Organ Injury and Mortality in Septic Mice Reviewed

    Imaizumi Takahiro, Matsuda Naoyuki, Tomita Kengo, Palikhe Sailesh, Ohashi Wakana, Hattori Kohshi, Hattori Yuichi

    CRITICAL CARE MEDICINE   Vol. 46 ( 5 ) page: E435 - E442   2018.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000003009

    Web of Science

    PubMed

  11. Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: attribution to phosphodiesterase 4 upregulation Reviewed

    Sakai Mari, Suzuki Tokiko, Tomita Kengo, Yamashita Shigeyuki, Palikhe Sailesh, Hattori Kohshi, Yoshimura Naoki, Matsuda Naoyuki, Hattori Yuichi

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   Vol. 312 ( 6 ) page: H1224-H1237   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpheart.00828.2016

    Web of Science

    PubMed

  12. CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracy Reviewed

    Nishikimi Mitsuaki, Matsuda Naoyuki, Matsui Kota, Takahashi Kunihiko, Ejima Tadashi, Liu Keibun, Ogura Takayuki, Higashi Michiko, Umino Hitoshi, Makishi Go, Numaguchi Atsushi, Matsushima Satoru, Tokuyama Hideki, Nakamura Mitsunobu, Matsui Shigeyuki

    INTENSIVE CARE MEDICINE   Vol. 42 ( 12 ) page: 2106-2107   2016.12

     More details

    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00134-016-4492-3

    Web of Science

    PubMed

  13. *Silencing of Fas-associated Death Domain Protects Mice from Septic Lung Inflammation and Apoptosis. Reviewed

    Matsuda N,Yamamoto S, Takano KI, Kageyama SI, Kurobe Y, Yoshiwara Y, Takano Y, Hattori Y.

    Am J Respir Crit Care Med   Vol. 79   page: 806-815   2009.6

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  14. *Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock. Reviewed

    Matsuda N,Takano Y,Kageyama S,Hatakeyama N,Shakunaga K,Kitajima I,Yamazaki M,Hattori Y.

    Cardiovasc Res   Vol. 76   page: 132-140   2007.6

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  15. *Nuclear Factor-kB decoy oligonucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis. Reviewed

    Matsuda N,Hattori Y,Takahashi Y,Subrina Jesmin,Gando S.

    Mol Pharmacol   Vol. 67   page: 1018-1025   2005.5

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  16. Therapeutic effect of in vivo transfection of transcription factor decoy to NF-kB on septic lung in mice. Reviewed

    Matsuda N,Hattori Y,Takahashi Y,Nishihira J,Jesmin S,Kobayashi M,Gando S.

    Am J Physiol Lung Cell Mol Physiol   Vol. 287   page: L1248-L1255   2004.4

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  17. [Molecular mechanisms underlying the pathogenesis of septic multiple organ failure].

    Matsuda N, Machida T, Hattori Y

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica   Vol. 159 ( 2 ) page: 101 - 106   2024

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1254/fpj.23109

    PubMed

  18. Administration of lipid emulsion reduced the hypnotic potency of propofol more than that of thiamylal in mice Reviewed

    Higashi, M; Taharabaru, S; Adachi, YU; Satomoto, M; Tamura, T; Matsuda, N; Sato-Boku, A; Okuda, M

    EXPERIMENTAL ANIMALS   Vol. 72 ( 4 ) page: 468 - 474   2023

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1538/expanim.23-0010

    Web of Science

    PubMed

  19. Survey on the current status of the indication and implementation protocols for bile replacement in patients with external biliary drainage with special reference to infection control

    Shinkawa, H; Kubo, S; Mikamo, H; Matsuda, N; Omura, K; Okamoto, K; Ono, S; Obara, H; Kobayashi, M; Sasaki, J; Shimizu, J; Sueyoshi, S; Yoshida, J; Watanabe, M; Takesue, Y

    SURGERY TODAY   Vol. 52 ( 10 ) page: 1446 - 1452   2022.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-022-02475-x

    Web of Science

    PubMed

  20. [Vascular hyperpermeable molecules potentially contributing to the development of pulmonary edema in sepsis-associated ARDS].

    Hattori K, Matsuda N, Hattori Y

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica   Vol. 157 ( 4 ) page: 226 - 231   2022

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1254/fpj.22013

    PubMed

  21. Impact of a long-term high-glucose environment on pro-inflammatory responses in macrophages stimulated with lipopolysaccharide

    Suzuki Tokiko, Yamashita Shigeyuki, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY     2021.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00210-021-02137-8

    Web of Science

    PubMed

  22. Outcome Related to Level of Targeted Temperature Management in Postcardiac Arrest Syndrome of Low, Moderate, and High Severities: A Nationwide Multicenter Prospective Registry

    Nishikimi Mitsuaki, Ogura Takayuki, Nishida Kazuki, Hayashida Kei, Emoto Ryo, Matsui Shigeyuki, Matsuda Naoyuki, Iwami Taku

    CRITICAL CARE MEDICINE   Vol. 49 ( 8 ) page: E741 - E750   2021.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000005025

    Web of Science

    PubMed

  23. Relative platelet reductions provide better pathophysiologic signatures of coagulopathies in sepsis

    Kasugai Daisuke, Ozaki Masayuki, Nishida Kazuki, Goto Yukari, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 14033   2021.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-93635-5

    Web of Science

    PubMed

  24. Failure of non-invasive respiratory support after 6 hours from initiation is associated with ICU mortality

    Nishikimi Mitsuaki, Nishida Kazuki, Shindo Yuichiro, Shoaib Muhammad, Kasugai Daisuke, Yasuda Yuma, Higashi Michiko, Numaguchi Atsushi, Yamamoto Takanori, Matsui Shigeyuki, Matsuda Naoyuki

    PLOS ONE   Vol. 16 ( 4 ) page: e0251030   2021.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0251030

    Web of Science

    PubMed

  25. A case of reexpansion pulmonary edema and acute pulmonary thromboembolism associated with diffuse large B-cell lymphoma treated with venovenous extracorporeal membrane oxygenation.

    Kazama S, Hiraiwa H, Kimura Y, Ozaki R, Shibata N, Arao Y, Oishi H, Kato H, Kuwayama T, Yamaguchi S, Kondo T, Furusawa K, Morimoto R, Okumura T, Bando YK, Sato T, Shimada K, Kiyoi H, Nakamura G, Yasuda Y, Kasugai D, Ogawa H, Higashi M, Yamamoto T, Jingushi N, Ozaki M, Numaguchi A, Goto Y, Matsuda N, Murohara T

    Journal of cardiology cases   Vol. 23 ( 1 ) page: 53 - 56   2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jccase.2020.08.013

    PubMed

  26. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).

    Egi M, Ogura H, Yatabe T, Atagi K, Inoue S, Iba T, Kakihana Y, Kawasaki T, Kushimoto S, Kuroda Y, Kotani J, Shime N, Taniguchi T, Tsuruta R, Doi K, Doi M, Nakada TA, Nakane M, Fujishima S, Hosokawa N, Masuda Y, Matsushima A, Matsuda N, Yamakawa K, Hara Y, Sakuraya M, Ohshimo S, Aoki Y, Inada M, Umemura Y, Kawai Y, Kondo Y, Saito H, Taito S, Takeda C, Terayama T, Tohira H, Hashimoto H, Hayashida K, Hifumi T, Hirose T, Fukuda T, Fujii T, Miura S, Yasuda H, Abe T, Andoh K, Iida Y, Ishihara T, Ide K, Ito K, Ito Y, Inata Y, Utsunomiya A, Unoki T, Endo K, Ouchi A, Ozaki M, Ono S, Katsura M, Kawaguchi A, Kawamura Y, Kudo D, Kubo K, Kurahashi K, Sakuramoto H, Shimoyama A, Suzuki T, Sekine S, Sekino M, Takahashi N, Takahashi S, Takahashi H, Tagami T, Tajima G, Tatsumi H, Tani M, Tsuchiya A, Tsutsumi Y, Naito T, Nagae M, Nagasawa I, Nakamura K, Nishimura T, Nunomiya S, Norisue Y, Hashimoto S, Hasegawa D, Hatakeyama J, Hara N, Higashibeppu N, Furushima N, Furusono H, Matsuishi Y, Matsuyama T, Minematsu Y, Miyashita R, Miyatake Y, Moriyasu M, Yamada T, Yamada H, Yamamoto R, Yoshida T, Yoshida Y, Yoshimura J, Yotsumoto R, Yonekura H, Wada T, Watanabe E, Aoki M, Asai H, Abe T, Igarashi Y, Iguchi N, Ishikawa M, Ishimaru G, Isokawa S, Itakura R, Imahase H, Imura H, Irinoda T, Uehara K, Ushio N, Umegaki T, Egawa Y, Enomoto Y, Ota K, Ohchi Y, Ohno T, Ohbe H, Oka K, Okada N, Okada Y, Okano H, Okamoto J, Okuda H, Ogura T, Onodera Y, Oyama Y, Kainuma M, Kako E, Kashiura M, Kato H, Kanaya A, Kaneko T, Kanehata K, Kano KI, Kawano H, Kikutani K, Kikuchi H, Kido T, Kimura S, Koami H, Kobashi D, Saiki I, Sakai M, Sakamoto A, Sato T, Shiga Y, Shimoto M, Shimoyama S, Shoko T, Sugawara Y, Sugita A, Suzuki S, Suzuki Y, Suhara T, Sonota K, Takauji S, Takashima K, Takahashi S, Takahashi Y, Takeshita J, Tanaka Y, Tampo A, Tsunoyama T, Tetsuhara K, Tokunaga K, Tomioka Y, Tomita K, Tominaga N, Toyosaki M, Toyoda Y, Naito H, Nagata I, Nagato T, Nakamura Y, Nakamori Y, Nahara I, Naraba H, Narita C, Nishioka N, Nishimura T, Nishiyama K, Nomura T, Haga T, Hagiwara Y, Hashimoto K, Hatachi T, Hamasaki T, Hayashi T, Hayashi M, Hayamizu A, Haraguchi G, Hirano Y, Fujii R, Fujita M, Fujimura N, Funakoshi H, Horiguchi M, Maki J, Masunaga N, Matsumura Y, Mayumi T, Minami K, Miyazaki Y, Miyamoto K, Murata T, Yanai M, Yano T, Yamada K, Yamada N, Yamamoto T, Yoshihiro S, Tanaka H, Nishida O

    Acute medicine & surgery   Vol. 8 ( 1 ) page: e659   2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ams2.659

    PubMed

  27. JM-1232(-) and propofol, a new combination of hypnotics with short-acting and non-cumulative preferable properties

    Taharabaru, S; Tamura, T; Higashi, M; Matsuda, N; Satomoto, M; Adachi, YU; Sato, AB; Okuda, M

    EXPERIMENTAL ANIMALS   Vol. 70 ( 1 ) page: 101 - 107   2021

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1538/expanim.20-0071

    Web of Science

    PubMed

  28. Relative bradycardia as a clinical feature in patients with coronavirus disease 2019 (COVID-19): A report of two cases.

    Hiraiwa H, Goto Y, Nakamura G, Yasuda Y, Sakai Y, Kasugai D, Jinno S, Tanaka T, Ogawa H, Higashi M, Yamamoto T, Jingushi N, Ozaki M, Numaguchi A, Kondo T, Morimoto R, Okumura T, Matsuda N, Murohara T

    Journal of cardiology cases   Vol. 22 ( 6 ) page: 260 - 264   2020.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jccase.2020.07.015

    PubMed

  29. Vascular endothelial growth factor contributes to lung vascular hyperpermeability in sepsis-associated acute lung injury

    Tomita Kengo, Saito Yuna, Suzuki Tokiko, Imbaby Samar, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY   Vol. 393 ( 12 ) page: 2365 - 2374   2020.12

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00210-020-01947-6

    Web of Science

    PubMed

  30. High-flow nasal cannula therapy for acute respiratory failure in patients with interstitial pneumonia: a retrospective observational study

    Omote, N; Matsuda, N; Hashimoto, N; Nishida, K; Sakamoto, K; Ando, A; Nakahara, Y; Nishikimi, M; Higashi, M; Matsu, S; Hasegawa, Y

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 2 ) page: 301 - 313   2020.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.82.2.301

    Web of Science

    PubMed

  31. STAT3 decoy oligodeoxynucleotides improve end-organ tissue injury and survival in septic mice

    Matsuda Naoyuki, Imbaby Samar, Hattori Kohshi, Hattori Yuichi

    FASEB JOURNAL   Vol. 34   2020.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1096/fasebj.2020.34.s1.03240

    Web of Science

  32. Delving into the caregiver burden associated basic activity of daily living disability among caregivers of patients with mild-to-moderate Alzheimer's disease

    Kawaharada Rika, Sugimoto Taiki, Tsuboi Yamato, Matsuda Naoka, Sakurai Takashi, Ono Rei

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 20 ( 3 ) page: 263 - 265   2020.3

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ggi.13862

    Web of Science

  33. Relationship Between Serum Norepinephrine Levels at ICU Admission and the Risk of ICU-Acquired Delirium: Secondary Analysis of the Melatonin Evaluation of Lowered Inflammation of ICU Trial.

    Yasuda Y, Nishikimi M, Nishida K, Takahashi K, Numaguchi A, Higashi M, Matsui S, Matsuda N

    Critical care explorations   Vol. 2 ( 2 ) page: e0082   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCE.0000000000000082

    PubMed

  34. Clinical Frailty Scale Score Before ICU Admission Is Associated With Mobility Disability in Septic Patients Receiving Early Rehabilitation.

    Nakajima H, Nishikimi M, Shimizu M, Hayashi K, Inoue T, Nishida K, Takahashi K, Matsui S, Nishida Y, Matsuda N

    Critical care explorations   Vol. 1 ( 12 ) page: e0066   2019.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCE.0000000000000066

    PubMed

  35. External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management.

    Nishikimi M, Ogura T, Nishida K, Takahashi K, Nakamura M, Matsui S, Matsuda N, Iwami T

    Resuscitation   Vol. 140   page: 135-141   2019.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.resuscitation.2019.05.028

    PubMed

  36. Timing of administration of epinephrine predicts the responsiveness to epinephrine in norepinephrine-refractory septic shock: a retrospective study

    Kasugai Daisuke, Nishikimi Mitsuaki, Nishida Kazuki, Higashi Michiko, Yamamoto Takanori, Numaguchi Atsushi, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

    JOURNAL OF INTENSIVE CARE   Vol. 7   page: 20   2019.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40560-019-0377-1

    Web of Science

    PubMed

  37. miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury.

    Funahashi Y, Kato N, Masuda T, Nishio F, Kitai H, Ishimoto T, Kosugi T, Tsuboi N, Matsuda N, Maruyama S, Kadomatsu K

    Laboratory investigation; a journal of technical methods and pathology     2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41374-019-0190-4

    PubMed

  38. Hemodynamics of cardiac tamponade during extracorporeal membrane oxygenation support in a patient with fulminant myocarditis.

    Kondo T, Morimoto R, Yokoi T, Yamaguchi S, Kuwayama T, Haga T, Hiraiwa H, Sugiura Y, Watanabe N, Kano N, Ichii T, Fukaya K, Sawamura A, Okumura T, Yoshizumi T, Mutsuga M, Fujimoto K, Matsuda N, Usui A, Murohara T

    Journal of cardiology cases   Vol. 19 ( 1 ) page: 22-24   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jccase.2018.08.009

    PubMed

  39. Different involvement of the MAPK family in inflammatory regulation in human pulmonary microvascular endothelial cells stimulated with LPS and IFN-gamma

    Suzuki Tokiko, Sakata Kimimasa, Mizuno Natsumi, Palikhe Sailesh, Yamashita Shigeyuki, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

    IMMUNOBIOLOGY   Vol. 223 ( 12 ) page: 777-785   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.imbio.2018.08.003

    Web of Science

    PubMed

  40. Sleep, the Missing Link? Reply

    Nishikimi Mitsuaki, Numaguchi Atsushi, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

    CRITICAL CARE MEDICINE   Vol. 46 ( 12 ) page: E1225-E1226   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000003452

    Web of Science

    PubMed

  41. Early Administration of Ramelteon in the ICU: Effects Deserve Further Study Reply

    Nishikimi Mitsuaki, Numaguchi Atsushi, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

    CRITICAL CARE MEDICINE   Vol. 46 ( 10 ) page: E1010-E1011   2018.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000003315

    Web of Science

    PubMed

  42. Anti-inflammatory properties of cilostazol: Its interruption of DNA binding activity of NF-kappa B from the Toll-like receptor signaling pathways

    Sakamoto Takuya, Ohashi Wakana, Tomita Kengo, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

    INTERNATIONAL IMMUNOPHARMACOLOGY   Vol. 62   page: 120 - 131   2018.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.intimp.2018.06.021

    Web of Science

    PubMed

  43. Cardioprotective and functional effects of levosimendan and milrinone in mice with cecal ligation and puncture-induced sepsis

    Yamashita Shigeyuki, Suzuki Tokiko, Iguchi Keisuke, Sakamoto Takuya, Tomita Kengo, Yokoo Hiroki, Sakai Mari, Misawa Hiroki, Hattori Kohshi, Nagata Toshi, Watanabe Yasuhide, Matsuda Naoyuki, Yoshimura Naoki, Hattori Yuichi

    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY   Vol. 391 ( 9 ) page: 1021-1032   2018.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00210-018-1527-z

    Web of Science

    PubMed

  44. Nucleic-acid based gene therapy approaches for sepsis Reviewed

    Hattori Yuichi, Hattori Kohshi, Suzuki Tokiko, Palikhe Sailesh, Matsuda Naoyuki

    EUROPEAN JOURNAL OF PHARMACOLOGY   Vol. 833   page: 403-410   2018.8

     More details

    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ejphar.2018.06.031

    Web of Science

    PubMed

  45. Promising method for management of venoarterial extracorporeal membrane oxygenation: A case of severe heart failure successfully stabilized by "high-flow/vasodilation method".

    Kondo T, Sawamura A, Okumura T, Kano N, Morimoto R, Watanabe N, Hiraiwa H, Kuwayama T, Sugiura Y, Haga T, Yamaguchi S, Fukaya K, Yokoi T, Fujimoto K, Mutsuga M, Yoshizumi T, Matsuda N, Usui A, Murohara T

    Journal of cardiology cases   Vol. 18 ( 2 ) page: 81-84   2018.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jccase.2018.05.002

    PubMed

  46. Differential effect of mild therapeutic hypothermia depending on the findings of hypoxic encephalopathy on early CT images in patients with post-cardiac arrest syndrome

    Nishikimi Mitsuaki, Ogura Takayuki, Nishida Kazuki, Takahashi Kunihiko, Fukaya Kenji, Liu Keibun, Nakamura Mitsunobu, Matsui Shigeyuki, Matsuda Naoyuki

    RESUSCITATION   Vol. 128   page: 11-15   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.resuscitation.2018.04.029

    Web of Science

    PubMed

  47. Role of G protein-coupled receptor kinase 2 in oxidative and nitrosative stress-related neurohistopathological changes in a mouse model of sepsis-associated encephalopathy

    Kawakami Masaaki, Hattori Mizuki, Ohashi Wakana, Fujimori Toshio, Hattori Kohshi, Takebe Mariko, Tomita Kengo, Yokoo Hiroki, Matsuda Naoyuki, Yamazaki Mitsuaki, Hattori Yuichi

    JOURNAL OF NEUROCHEMISTRY   Vol. 145 ( 6 ) page: 474-488   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jnc.14329

    Web of Science

    PubMed

  48. MIR-146A TARGETING SPLENIC MACROPHAGES PREVENTS SEPSIS-INDUCED MULTIPLE ORGAN INJURY INCLUDING ACUTE KIDNEY INJURY

    Funahashi Yoshio, Kato Noritoshi, Kitai Hiroki, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Matsuda Naoyuki, Maruyama Shoichi, Kadomatsu Kenji

    SHOCK   Vol. 49 ( 6 ) page: 21-21   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  49. Inducible nitric oxide synthase during the late phase of sepsis is associated with hypothermia and immune cell migration Reviewed

    Takatani Yudai, Ono Kenji, Suzuki Hiromi, Inaba Masato, Sawad Makoto, Matsuda Naoyuki

    LABORATORY INVESTIGATION   Vol. 98 ( 5 ) page: 629-639   2018.5

     More details

    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41374-018-0021-z

    Web of Science

    PubMed

  50. Accuracy of the first interpretation of early brain CT images for predicting the prognosis of post-cardiac arrest syndrome patients at the emergency department

    Nishikimi Mitsuaki, Ogura Takayuki, Matsui Kota, Takahashi Kunihiko, Fukaya Kenji, Liu Keibun, Morita Hideo, Nakamura Mitsunobu, Matsui Shigeyuki, Matsuda Naoyuki

    JOURNAL OF INTENSIVE CARE   Vol. 6   page: 26   2018.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40560-018-0296-6

    Web of Science

    PubMed

  51. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

    Nishida Osamu, Ogura Hiroshi, Egi Moritoki, Fujishima Seitaro, Hayashi Yoshiro, Iba Toshiaki, Imaizumi Hitoshi, Inoue Shigeaki, Kakihana Yasuyuki, Kotani Joji, Kushimoto Shigeki, Masuda Yoshiki, Matsuda Naoyuki, Matsushima Asako, Nakada Taka-aki, Nakagawa Satoshi, Nunomiya Shin, Sadahiro Tomohito, Shime Nobuaki, Yatabe Tomoaki, Hara Yoshitaka, Hayashida Kei, Kondo Yutaka, Sumi Yuka, Yasuda Hideto, Aoyama Kazuyoshi, Azuhata Takeo, Doi Kent, Doi Matsuyuki, Fujimura Naoyuki, Fuke Ryota, Fukuda Tatsuma, Goto Koji, Hasegawa Ryuichi, Hashimoto Satoru, Hatakeyama Junji, Hayakawa Mineji, Hifumi Toru, Higashibeppu Naoki, Hirai Katsuki, Hirose Tomoya, Ide Kentaro, Kaizuka Yasuo, Kan'o Tomomichi, Kawasaki Tatsuya, Kuroda Hiromitsu, Matsuda Akihisa, Matsumoto Shotaro, Nagae Masaharu, Onodera Mutsuo, Ohnuma Tetsu, Oshima Kiyohiro, Saito Nobuyuki, Sakamoto So, Sakuraya Masaaki, Sasano Mikio, Sato Norio, Sawamura Atsushi, Shimizu Kentaro, Shirai Kunihiro, Takei Tetsuhiro, Takeuchi Muneyuki, Takimoto Kohei, Taniguchi Takumi, Tatsumi Hiroomi, Tsuruta Ryosuke, Yama Naoya, Yamakawa Kazuma, Yamashita Chizuru, Yamashita Kazuto, Yoshida Takeshi, Tanaka Hiroshi, Oda Shigeto

    JOURNAL OF INTENSIVE CARE   Vol. 6   page: 7   2018.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40560-017-0270-8

    Web of Science

    PubMed

  52. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

    Nishida Osamu, Ogura Hiroshi, Egi Moritoki, Fujishima Seitaro, Hayashi Yoshiro, Iba Toshiaki, Imaizumi Hitoshi, Inoue Shigeaki, Kakihana Yasuyuki, Kotani Joji, Kushimoto Shigeki, Masuda Yoshiki, Matsuda Naoyuki, Matsushima Asako, Nakada Taka-aki, Nakagawa Satoshi, Nunomiya Shin, Sadahiro Tomohito, Shime Nobuaki, Yatabe Tomoaki, Hara Yoshitaka, Hayashida Kei, Kondo Yutaka, Sumi Yuka, Yasuda Hideto, Aoyama Kazuyoshi, Azuhata Takeo, Doi Kent, Doi Matsuyuki, Fujimura Naoyuki, Fuke Ryota, Fukuda Tatsuma, Goto Koji, Hasegawa Ryuichi, Hashimoto Satoru, Hatakeyama Junji, Hayakawa Mineji, Hifumi Toru, Higashibeppu Naoki, Hirai Katsuki, Hirose Tomoya, Ide Kentaro, Kaizuka Yasuo, Kan'o Tomomichi, Kawasaki Tatsuya, Kuroda Hiromitsu, Matsuda Akihisa, Matsumoto Shotaro, Nagae Masaharu, Onodera Mutsuo, Ohnuma Tetsu, Oshima Kiyohiro, Saito Nobuyuki, Sakamoto So, Sakuraya Masaaki, Sasano Mikio, Sato Norio, Sawamura Atsushi, Shimizu Kentaro, Shirai Kunihiro, Takei Tetsuhiro, Takeuchi Muneyuki, Takimoto Kohei, Taniguchi Takumi, Tatsumi Hiroomi, Tsuruta Ryosuke, Yama Naoya, Yamakawa Kazuma, Yamashita Chizuru, Yamashita Kazuto, Yoshida Takeshi, Tanaka Hiroshi, Oda Shigeto

    ACUTE MEDICINE & SURGERY   Vol. 5 ( 1 ) page: 3-89   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ams2.322

    Web of Science

    PubMed

  53. High-Flow Nasal Cannula Therapy for Acute Respiratory Failure in Patients with Interstitial Pneumonia: A Retrospective Observational Study

    Omote N., Hashimoto N., Matsuda N., Nishida K., Sakamoto K., Ando A., Nakahara Y., Nishikimi M., Higashi M., Matsui S., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 197   page: .   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  54. Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: Novel therapeutic implications and challenges

    Hattori Yuichi, Hattori Kohshi, Suzuki Tokiko, Matsuda Naoyuki

    PHARMACOLOGY & THERAPEUTICS   Vol. 177   page: 56-66   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pharmthera.2017.02.040

    Web of Science

    PubMed

  55. A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS

    Yamamoto Seiji, Muramatsu Masashi, Azuma Erika, Ikutani Masashi, Nagai Yoshinori, Sagara Hiroshi, Koo Bon-Nyeo, Kita Satomi, O'Donnell Erin, Osawa Tsuyoshi, Takahashi Hiroyuki, Takano Ken-ichi, Dohmoto Mitsuko, Sugimori Michiya, Usui Isao, Watanabe Yasuhide, Hatakeyama Noboru, Iwamoto Takahiro, Komuro Issei, Takatsu Kiyoshi, Tobe Kazuyuki, Niida Shumpei, Matsuda Naoyuki, Shibuya Masabumi, Sasahara Masakiyo

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page: 3855   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-03994-1

    Web of Science

    PubMed

  56. Plasmapheresis therapy has no triglyceride-lowering effect in patients with hypertriglyceridemic pancreatitis

    Miyamoto Kyohei, Horibe Masayasu, Sanui Masamitsu, Sasaki Mitsuhito, Sugiyama Daisuke, Kato Seiya, Yamashita Takahiro, Goto Takashi, Iwasaki Eisuke, Shirai Kunihiro, Oe Kyoji, Sawano Hirotaka, Oda Takuya, Yasuda Hideto, Ogura Yuki, Hirose Kaoru, Kitamura Katsuya, Chiba Nobutaka, Ozaki Tetsu, Oshima Taku, Yamamoto Tomonori, Nagata Keiji, Mine Tetsuya, Saito Koji, Sekino Motohiro, Furuya Tomoki, Matsuda Naoyuki, Hayakawa Mineji, Kanai Takanori, Mayumi Toshihiko

    INTENSIVE CARE MEDICINE   Vol. 43 ( 6 ) page: 949-951   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00134-017-4722-3

    Web of Science

    PubMed

  57. A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score

    Nishikimi Mitsuaki, Matsuda Naoyuki, Matsui Kota, Takahashi Kunihiko, Ejima Tadashi, Liu Keibun, Ogura Takayuki, Higashi Michiko, Umino Hitoshi, Makishi Go, Numaguchi Atsushi, Matsushima Satoru, Tokuyama Hideki, Nakamura Mitsunobu, Matsui Shigeyuki

    SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE   Vol. 25 ( 1 ) page: 49   2017.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13049-017-0392-y

    Web of Science

    PubMed

  58. Regulation of the Cardiovascular System by Histamine

    Hattori Yuichi, Hattori Kohshi, Matsuda Naoyuki

    HISTAMINE AND HISTAMINE RECEPTORS IN HEALTH AND DISEASE   Vol. 241   page: 239-258   2017

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/164_2016_15

    Web of Science

    PubMed

  59. Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis.

    Hattori M, Yamazaki M, Ohashi W, Tanaka S, Hattori K, Todoroki K, Fujimori T, Ohtsu H, Matsuda N, Hattori Y

    Intensive care medicine experimental   Vol. 4 ( 1 ) page: 36   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40635-016-0109-y

    PubMed

  60. In vitro reduction of antibacterial activity of tigecycline against multidrug-resistant Acinetobacter baumannii with host stress hormone norepinephrine

    Inaba Masato, Matsuda Naoyuki, Banno Hirotsugu, Jin Wanchun, Wachino Jun-ichi, Yamada Keiko, Kimura Kouji, Arakawa Yoshichika

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS   Vol. 48 ( 6 ) page: 680-689   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijantimicag.2016.09.022

    Web of Science

    PubMed

  61. The International Activities in Taiwan by the Joint Burn Care Assistance Team of Physicians from Japan Medical Association and Three Medical Societies.

    Matsuda N, Yamada S, Hinoshita T, Sasaki J, Ikeda H, Harunari N, Sakamoto T

    Japan Medical Association journal : JMAJ   Vol. 59 ( 1 ) page: 12-16   2016.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  62. [Severe infection in critical emergency care].

    Matsuda N, Takatani Y, Higashi T, Inaba M, Ejima T

    Nihon rinsho. Japanese journal of clinical medicine   Vol. 74 ( 2 ) page: 245-51   2016.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  63. Alert cell strategy in SIRS-induced vasculitis: sepsis and endothelial cells

    Matsuda Naoyuki

    JOURNAL OF INTENSIVE CARE   Vol. 4   page: 21   2016

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40560-016-0147-2

    Web of Science

    PubMed

  64. Anti-Inflammatory Profile of Levosimendan in Cecal Ligation-Induced Septic Mice and in Lipopolysaccharide-Stimulated Macrophages

    Wang Qiang, Yokoo Hiroki, Takashina Michinori, Sakata Kimimasa, Ohashi Wakana, Abedelzaher Lobna A., Imaizumi Takahiro, Sakamoto Takuya, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

    CRITICAL CARE MEDICINE   Vol. 43 ( 11 ) page: E508 - E520   2015.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000001269

    Web of Science

    PubMed

  65. Radial artery cannulation decreases the distal arterial blood flow measured by power Doppler ultrasound

    Numaguchi Atsushi, Adachi Yushi U., Aoki Yoshitaka, Ishii Yasuhiro, Suzuki Katsumi, Obata Yukako, Sato Shigehito, Nishiwaki Kimitoshi, Matsuda Naoyuki

    JOURNAL OF CLINICAL MONITORING AND COMPUTING   Vol. 29 ( 5 ) page: 653-657   2015.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10877-014-9648-5

    Web of Science

    PubMed

  66. Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes

    Yamamoto Seiji, Niida Shumpei, Azuma Erika, Yanagibashi Tsutomu, Muramatsu Masashi, Huang Ting Ting, Sagara Hiroshi, Higaki Sayuri, Ikutani Masashi, Nagai Yoshinori, Takatsu Kiyoshi, Miyazaki Kenji, Hamashima Takeru, Mori Hisashi, Matsuda Naoyuki, Ishii Yoko, Sasahara Masakiyo

    SCIENTIFIC REPORTS   Vol. 5   page: 8505   2015.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep08505

    Web of Science

    PubMed

  67. Ultrasonography-guided radial artery catheterization and further optimal sequences

    Adachi Yushi U., Numaguchi Atsushi, Matsuda Naoyuki

    JOURNAL OF CLINICAL MONITORING AND COMPUTING   Vol. 29 ( 1 ) page: 201-202   2015.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10877-014-9608-0

    Web of Science

    PubMed

  68. Lingual tonsil hypertrophy diagnosed by post-mortem computed tomography in a difficult airway case

    Hinoshita T., Numaguchi A., Adachi Y. U., Nakahara K., Matsuda N.

    ACTA ANAESTHESIOLOGICA SCANDINAVICA   Vol. 58 ( 9 ) page: 1162-1163   2014.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/aas.12388

    Web of Science

  69. Continuous administration of landiolol reduced QT dispersion in postoperative patients

    Suzuki Katsumi, Numaguchi Atsushi, Adachi Yushi U., Obata Yukako, Hatano Toshiyuki, Ejima Tadashi, Sato Shigehito, Matsuda Naoyuki

    JOURNAL OF CLINICAL ANESTHESIA   Vol. 26 ( 6 ) page: 438-442   2014.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jclinane.2014.01.017

    Web of Science

    PubMed

  70. Not only bupivacaine but also propofol is sinking in lipid?

    Adachi Yushi U., Numaguchi Atsushi, Matsuda Naoyuki

    JOURNAL OF ANESTHESIA   Vol. 28 ( 3 ) page: 476-476   2014.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00540-013-1725-2

    Web of Science

    PubMed

  71. Alert Cell Strategy: Mechanisms of Inflammatory Response and Organ Protection. Reviewed

    Noboru Hatakeyama, Naoyuki Matsuda

    Curr Pharm Des   Vol. 20   page: 5766-5778   2014.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  72. Alert cell strategy: mechanisms of inflammatory response and organ protection.

    Hatakeyama N, Matsuda N

    Current pharmaceutical design   Vol. 20 ( 36 ) page: 5766-78   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  73. The Japanese guidelines for the management of sepsis.

    Oda S, Aibiki M, Ikeda T, Imaizumi H, Endo S, Ochiai R, Kotani J, Shime N, Nishida O, Noguchi T, Matsuda N, Hirasawa H, Sepsis Registry Committee of The Japanese Society of Intensive Care Medicine.

    Journal of intensive care   Vol. 2 ( 1 ) page: 55   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40560-014-0055-2

    PubMed

  74. Landiolol reduces hemodynamic responses to bronchoscopy-assisted suctioning in intubated ICU patients.

    Tochikubo J, Adachi YU, Ejima T, Numaguchi A, Matsuda N, Sato S, Shiiya N

    Journal of intensive care   Vol. 2 ( 1 ) page: 6   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/2052-0492-2-6

    PubMed

  75. Alert Cell Strategy: Mechanisms of Inflammatory Response and Organ Protection

    Hatakeyama Noboru, Matsuda Naoyuki

    CURRENT PHARMACEUTICAL DESIGN   Vol. 20 ( 36 ) page: 5766-5778   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  76. The advanced radial artery cannulation using Insyte-A (TM) with real-time ultrasound guidance

    Adachi Yushi U., Hatano Toshiyuki, Hashimoto Shinsuke, Ejima Tadashi, Murase Kichiro, Matsuda Naoyuki

    JOURNAL OF CLINICAL MONITORING AND COMPUTING   Vol. 27 ( 6 ) page: 703-704   2013.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10877-013-9482-1

    Web of Science

    PubMed

  77. BUNDLE-BASED MANAGEMENT OF SEPTIC SHOCK IN NAGOYA UNIVERSITY EMERGENCY AND MEDICAL ICU

    Matsuda N., Matsushima S., Hashimoto S., Ejima M., Takatani Y., Higashi M., Inaba M., Ohbayashi M., Asada K., Umino J., Hinoshita T., Numaguchi A., Kado M., Adachi Y., Takahashi H.

    INTENSIVE CARE MEDICINE   Vol. 39   page: S480-S480   2013.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  78. INFLAMMATION-INDUCED AUTOPHAGY HUMAN VASCULAR ENDOTHELIAL CELLS

    Matsuda N., Konishi Y., Itoh R., Tochikubo J., Adachi Y.

    INTENSIVE CARE MEDICINE   Vol. 39   page: S239-S240   2013.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  79. The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons

    Koyano Fumika, Okatsu Kei, Ishigaki Shinsuke, Fujioka Yusuke, Kimura Mayumi, Sobue Gen, Tanaka Keiji, Matsuda Noriyuki

    GENES TO CELLS   Vol. 18 ( 8 ) page: 672-681   2013.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12066

    Web of Science

  80. Recurarization after sugammadex following a prolonged rocuronium infusion for induced hypothermia

    Murata Tetsuya, Kubodera Toshi, Ohbayashi Masakazu, Murase Kichiro, Adachi Yushi U., Matsuda Naoyuki

    CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE   Vol. 60 ( 5 ) page: 508-509   2013.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12630-013-9909-7

    Web of Science

    PubMed

  81. Intravenous droperidol decreases the bispectral index during general anesthesia with sevoflurane and remifentanil.

    Adachi YU, Tanaka K, Suzuki S, Nishiwaki K, Matsuda N

    Masui. The Japanese journal of anesthesiology   Vol. 62 ( 1 ) page: 71-4   2013.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  82. Subcutaneous emphysema and ultrasound sonography.

    Kubodera T, Adachi YU, Hatano T, Ejima T, Numaguchi A, Matsuda N

    Journal of intensive care   Vol. 1 ( 1 ) page: 8   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/2052-0492-1-8

    PubMed

  83. The effect of aging on dopamine release and metabolism during sevoflurane anesthesia in rat striatum: An in vivo microdialysis study

    Kimura-Kuroiwa Kaori, Adachi Yushi U., Mimuro Soichiro, Obata Yukako, Kawamata Mikito, Sato Shigehito, Matsuda Naoyuki

    BRAIN RESEARCH BULLETIN   Vol. 89 ( 5-6 ) page: 223-230   2012.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.brainresbull.2012.08.006

    Web of Science

    PubMed

  84. NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte apoptosis.

    Matsuno K, Iwata K, Matsumoto M, Katsuyama M, Cui W, Murata A, Nakamura H, Ibi M, Ikami K, Zhang J, Matoba S, Jin D, Takai S, Matsubara H, Matsuda N, Yabe-Nishimura C

    Free radical biology & medicine   Vol. 53 ( 9 ) page: 1718-28   2012.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.freeradbiomed.2012.08.590

    PubMed

  85. [ECG changes after the induction of general anesthesia with remifentanil: a report of three case].

    Tanaka K, Adachi Y, Suzuki S, Nishiwaki K, Matsuda N

    Masui. The Japanese journal of anesthesiology   Vol. 61 ( 10 ) page: 1128-32   2012.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  86. TAK-1 SIRNA NORMALIZES AUTOPHAGY AND APOPTOSIS IN SEPTIC MOUSE LUNG

    Matsuda N., Tochikubo J., Tamura T., Tsuzuki M., Murase K., Adachi Y.

    INTENSIVE CARE MEDICINE   Vol. 38   page: S18-S18   2012.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  87. MODULATION OF EXPRESSION AND FUNCTION OF ION CHANNELS IN ATRIAL MYOCYTE FROM SEPTIC GUINEA PIG

    Hatakeyama N., Aoki Y., Sakakibara K., Matsuda N., Kinoshita H., Fujiwara Y.

    INTENSIVE CARE MEDICINE   Vol. 38   page: S103-S103   2012.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  88. Epidural catheter insertion during general anesthesia

    Adachi Yushi U., Matsuda Naoyuki

    JOURNAL OF ANESTHESIA   Vol. 26 ( 4 ) page: 633-633   2012.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00540-012-1382-x

    Web of Science

    PubMed

  89. Is it constantly possible to penetrate only the anterior vessel wall against hydrostatic strain?

    Adachi Yushi U., Tuzuki Michitaka, Matsuda Naoyuki

    CRITICAL CARE MEDICINE   Vol. 40 ( 8 ) page: 2534-2535   2012.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e31825453ff

    Web of Science

    PubMed

  90. Is it fluid or air causing anesthesia mumps?

    Adachi Yushi U., Matsuda Naoyuki

    JOURNAL OF ANESTHESIA   Vol. 26 ( 4 ) page: 638-639   2012.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00540-012-1387-5

    Web of Science

    PubMed

  91. Evaluating patient self-assessment of health as a predictor of hospital admission in emergency practice: a diagnostic validity study

    Miyamichi Ryosuke, Mayumi Toshihiko, Asaoka Mineo, Matsuda Naoyuki

    EMERGENCY MEDICINE JOURNAL   Vol. 29 ( 7 ) page: 570-575   2012.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/emj.2010.105247

    Web of Science

    PubMed

  92. Isoflurane Pretreatment Preserves Adenosin Triphosphate-Sensitive K+ Channel Function in the Human Artery Exposed to Oxidative Stress Caused by High Glucose Levels

    Kinoshita Hiroyuki, Matsuda Naoyuki, Iranami Hiroshi, Ogawa Koji, Hatakeyama Noboru, Azma Toshiharu, Kawahito Shinji, Yamazaki Mitsuaki

    ANESTHESIA AND ANALGESIA   Vol. 115 ( 1 ) page: 54-61   2012.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1213/ANE.0b013e318254270d

    Web of Science

    PubMed

  93. Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice

    Kimura-Kuroiwa Kaori, Adachi Yushi U., Obata Yukako, Kawamata Mikito, Sato Shigehito, Matsuda Naoyuki

    JOURNAL OF ANESTHESIA   Vol. 26 ( 3 ) page: 422-428   2012.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00540-012-1344-3

    Web of Science

    PubMed

  94. Role of ion channels in sepsis-induced atrial tachyarrhythmias in guinea pigs

    Aoki Yuta, Hatakeyama Noboru, Yamamoto Seiji, Kinoshita Hiroyuki, Matsuda Naoyuki, Hattori Yuichi, Yamazaki Mitsuaki

    BRITISH JOURNAL OF PHARMACOLOGY   Vol. 166 ( 1 ) page: 390-400   2012.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1476-5381.2011.01769.x

    Web of Science

    PubMed

  95. Pentobarbital Decreased Nitric Oxide Release in the Rat Striatum but Ketamine Increased the Release Independent of Cholinergic Regulation

    Kimura-Kuroiwa Kaori, Adachi Yushi U., Mimuro Soichiro, Kawamata Mikito, Sato Shigehito, Matsuda Naoyuki

    EXPERIMENTAL ANIMALS   Vol. 61 ( 2 ) page: 165-170   2012.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  96. Cochlear Blood Flow and Speech Perception Ability in Cochlear Implant Users

    Nakashima Tsutomu, Hattori Taku, Sone Michihiko, Asahi Kiyomitsu, Matsuda Naoko, Teranishi Masaaki, Yoshida Tadao, Kato Ken, Sato Eisuke

    OTOLOGY & NEUROTOLOGY   Vol. 33 ( 2 ) page: 165-168   2012.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MAO.0b013e318241c0db

    Web of Science

  97. The effect of insulin may not be so simple.

    Kinoshita H, Matsuda N

    Anesthesiology   Vol. 116 ( 2 ) page: 488; author reply 489-90   2012.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/ALN.0b013e31823fd04d

    PubMed

  98. [Sudden increases and decreases in bispectral index values more than 30 within 1 minute during general anesthesia].

    Toriyama W, Adachi Y, Obata Y, Sato S, Matsuda N

    Masui. The Japanese journal of anesthesiology   Vol. 61 ( 2 ) page: 210-3   2012.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  99. Roles of neuronal nitric oxide synthase, oxidative stress, and propofol in N-methyl-D-aspartate-induced dilatation of cerebral arterioles

    Hama-Tomioka K., Kinoshita H., Nakahata K., Kondo T., Azma T., Kawahito S., Hatakeyama N., Matsuda N.

    BRITISH JOURNAL OF ANAESTHESIA   Vol. 108 ( 1 ) page: 21-29   2012.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/bja/aer368

    Web of Science

  100. ENDOPLASMIC RETICULUM STRESS SENSOR PROTEINS EXPRESSION AND ITS ALTERATION IN SEPSIS DEPEND ON CELL TYPES IN PANCREAS AND ADRENAL GLAND

    Suzuki T., Matsuda N., Teramae H., Sato N., Koike K.

    SHOCK   Vol. 37   page: 111-111   2012

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  101. Pentobarbital decreased nitric oxide release in the rat striatum but ketamine increased the release independent of cholinergic regulation.

    Kimura-Kuroiwa K, Adachi YU, Mimuro S, Kawamata M, Sato S, Matsuda N

    Experimental animals   Vol. 61 ( 2 ) page: 165-70   2012

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1538/expanim.61.165

    PubMed

  102. [Inflammatory alert cell strategy in septic acute lung injury].

    Matsuda N, Tsuzuki M, Ichikawa S, Tochikubo J, Tamura T, Adachi Y

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica   Vol. 138 ( 4 ) page: 151-4   2011.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  103. High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors.

    Kageyama S, Yokoo H, Tomita K, Kageyama-Yahara N, Uchimido R, Matsuda N, Yamamoto S, Hattori Y

    Cardiovascular diabetology   Vol. 10   page: 73   2011.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1475-2840-10-73

    PubMed

  104. Successful recovery from delayed amniotic fluid embolism with prolonged cardiac resuscitation.

    Hosono K, Matsumura N, Matsuda N, Fujiwara H, Sato Y, Konishi I

    The journal of obstetrics and gynaecology research   Vol. 37 ( 8 ) page: 1122-5   2011.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1447-0756.2010.01470.x

    PubMed

  105. Modification of endotracheal intubation using AirwayScope (TM) videolaryngoscope for straight reinforced tubes

    Minonishi T., Kinoshita H., Hirayama M., Hatakeyama N., Matsuda N.

    MINERVA ANESTESIOLOGICA   Vol. 77 ( 8 ) page: 850-851   2011.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  106. LEVELS OF ANTITHROMBIN ACTIVITY AFTER ANTITHROMBIN ADMINISTRATION INDICATE PROGNOSIS OF SEPTIC DIC PATIENTS

    Mayumi T., Suzuki S., Yamamoto T., Ichikawa T., Onodera M., Tsuzuki M., Kin B., Inoue T., Kainuma M., Takahashi H., Matsuda N., Nishiwaki K.

    SHOCK   Vol. 35   page: 13-13   2011.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  107. Successful treatment of acute lung injury with pitavastatin in septic mice: potential role of glucocorticoid receptor expression in alveolar macrophages.

    Takano K, Yamamoto S, Tomita K, Takashina M, Yokoo H, Matsuda N, Takano Y, Hattori Y

    The Journal of pharmacology and experimental therapeutics   Vol. 336 ( 2 ) page: 381-90   2011.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1124/jpet.110.171462

    PubMed

  108. Issues regarding propofol concentrations within the clinical range.

    Kinoshita H, Matsuda N

    Anesthesiology   Vol. 114 ( 1 ) page: 218; author reply 218-9   2011.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/ALN.0b013e3181ff728d

    PubMed

  109. Alert cell strategy for inflammation and cell death in septic ALI/ARDS

    Matsuda Naoyuki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 115   page: 38P - 38P   2011

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  110. Origin of the cerebral microvascular pericytes in the neurogenesis period

    Yamamoto Seiji, Muramatsu Masashi, Azuma Erika, Dohmoto Mitsuko, Takano Ken-ichi, Kita Satomi, Iwamoto Takahiro, Komuro Issei, Niida Shumpei, Shibuya Masabumi, Matsuda Naoyuki, Hattori Yuichi

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 115   page: 86P-86P   2011

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  111. FADD SIRNA REDUCES AUTOPHAGY AND APOPTOSIS IN SEPTIC MICE

    Matsuda Naoyuki, Teramae Hiroki

    CRITICAL CARE MEDICINE   Vol. 38 ( 12 ) page: U20-U20   2010.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  112. Insights Into Sepsis Therapeutic Design Based on the Apoptotic Death Pathway

    Hattori Yuichi, Takano Ken-ichi, Teramae Hiroki, Yamamoto Seiji, Yokoo Hiroki, Matsuda Naoyuki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 114 ( 4 ) page: 354-365   2010.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1254/jphs.10R04CR

    Web of Science

  113. MODULATION ON EXPRESSION AND FUNCTION OF CALCIUM AND POTASSIUM CHANNELS IN SEPTIC GUINEA PIG ATRIUM

    Hatakeyama Noboru, Aoki Yuta, Kinoshita Hiroyuki, Matsuda Naoyuki, Yamazaki Mitsuaki

    CRITICAL CARE MEDICINE   Vol. 38 ( 12 ) page: U51-U51   2010.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  114. The modulation of vascular ATP-sensitive K+ channel function via phosphatidylinositol 3-kinase-Akt pathway activated by phenylephrine. Reviewed

    Haba M, Hatakeyama N, Kinoshita H, Teramae H, Azma T, Hatano Y, Matsuda N.

    J Pharmacol Exp Ther   Vol. 334   page: 673-678   2010.9

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  115. Endothelial detachment, caused by low-shear stress and resulting in neointima formation in mice

    Tsuzuki M., Matsuda N., Okumura K., Murohara T.

    EUROPEAN HEART JOURNAL   Vol. 31   page: 403-404   2010.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  116. The Modulation of Vascular ATP-Sensitive K+ Channel Function via the Phosphatidylinositol 3-Kinase-Akt Pathway Activated by Phenylephrine

    Haba Masanori, Hatakeyama Noboru, Kinoshita Hiroyuki, Teramae Hiroki, Azma Toshiharu, Hatano Yoshio, Matsuda Naoyuki

    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS   Vol. 334 ( 2 ) page: 673-678   2010.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1124/jpet.110.167775

    Web of Science

    PubMed

  117. *Regulation of histamine H4 receptors contributes to splenic apoptosis in septic mice: counteraction of the anti-apoptotic action of nuclear factor-kB. Reviewed

    Matsuda N, Teramae H, Futatsugi M, Takano KI, Yamamoto S, Tomita K, Suzuki T, Yokoo H, Koike K, Hattori Y.

    J Pharmacol Exp Ther   Vol. 109   page: 1635-1643   2010.3

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  118. Up-regulation of histamine H4 receptors contributes to splenic apoptosis in septic mice: counteraction of the antiapoptotic action of nuclear factor-kappaB.

    Matsuda N, Teramae H, Futatsugi M, Takano K, Yamamoto S, Tomita K, Suzuki T, Yokoo H, Koike K, Hattori Y

    The Journal of pharmacology and experimental therapeutics   Vol. 332 ( 3 ) page: 730-7   2010.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1124/jpet.109.163543

    PubMed

  119. Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells

    Zhang Xiao-Hong, Yokoo Hiroki, Nishioka Hiroshi, Fujii Hajime, Matsuda Naoyuki, Hayashi Toshio, Hattori Yuichi

    BRITISH JOURNAL OF PHARMACOLOGY   Vol. 159 ( 4 ) page: 928-938   2010.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1476-5381.2009.00594.x

    Web of Science

    PubMed

  120. Tracheal intubation with the AirwayScope videolaryngoscope using straight vs curved reinforced tubes.

    Minonishi T, Kinoshita H, Tange K, Hatakeyama N, Matsuda N, Azma T, Hatano Y

    Canadian journal of anaesthesia = Journal canadien d'anesthesie   Vol. 57 ( 1 ) page: 92-3   2010.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12630-009-9210-y

    PubMed

  121. Increased death receptor pathway of apoptotic signaling in septic mouse aorta: effect of systemic delivery of FADD siRNA.

    Matsuda N, Teramae H, Yamamoto S, Takano K, Takano Y, Hattori Y

    American journal of physiology. Heart and circulatory physiology   Vol. 298 ( 1 ) page: H92-101   2010.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpheart.00069.2009

    PubMed

  122. Possible involvement of brain cytokines-modulating signaling pathways in hypothalamus in encephalopathy and development of sepsis in mice

    Imai Satoshi, Narita Minoru, Ishiwata Sayuri, Narita Michiko, Honda Natsuki, Niikura Keiichi, Kuzumaki Naoko, Matsuda Naoyuki, Suzuki Tsutomu

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 112   page: 25P-25P   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  123. Insights into sepsis therapeutic design based on the apoptotic death pathway.

    Hattori Y, Takano K, Teramae H, Yamamoto S, Yokoo H, Matsuda N

    Journal of pharmacological sciences   Vol. 114 ( 4 ) page: 354-65   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  124. Possible involvement of central cytokines and chemokines in the development of sepsis following cecal ligation and puncture in mice

    Ishiwata Sayuri, Narita Minoru, Narita Michiko, Honda Natsuki, Imai Satoshi, Niikura Keiichi, Kuzumaki Naoko, Matsuda Naoyuki, Suzuki Tsutomu

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 112   page: 107P-107P   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  125. *Nuclear factor-kB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis. Reviewed

    Matsuda N, Yamamoto S, Yokoo H, Tobe K, Hattori Y.

    Crit Care Med   Vol. 37   page: 2791-2799   2009.10

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  126. Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea-pig lungs using methylprednisolone. Reviewed

      Vol. 295   page: L998-L1006   2008.11

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  127. Priming by lipopolysaccharide exaggerates acute lung injury and mortality in responses to peptidoglycan through up-regulation of Toll-like receptor-2 expression in mice. Reviewed

    Matsuda N, Yamazaki H, Takano KI, Matsui K, Takano Y, Kemmotsu O, Hattori Y.

    Biochem Pharmacol   Vol. 75   page: 1065-1075   2008.11

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  128. Roles of phosphatidylinositol 3-kinase and NADPH oxidase in ATP-sensitive K+ channel function impaired by high glucose in the human artery. Reviewed

    Hypertension   Vol. 52   page: 507-513   2008.5

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  129. Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: reversal effect of fluvastatin therapy. Reviewed

    Matsuda N,Hayashi Y, Takahashi Y,Hattori Y.

    J Pharmacol Exp Ther   Vol. 319   page: 1348-1354   2006.10

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  130. Role of MIF in acute lung injury in mice with acute pancreatitis complicated by endotoxemia. Reviewed

    Matsuda N,Nishihira J,Takahashi Y,Kennmotsu O,Hattori Y.

    Am J Respir Cell Mol Biol   Vol. 35   page: 198-205   2006.7

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

▼display all

Books 31

  1. Perioperative/postoperative management – ​​Surgical intensive care Q&A –

    Naoyuki Matsuda( Role: Edit)

    2024.11  ( ISBN:978-4-88378-584-1

     More details

    Total pages:236   Responsible for pages:1~236   Language:Japanese Book type:Textbook, survey, introduction

    General Overview
    1. The Mechanism and System of Surgical Intensive Care
    2. Handover and Conferences in the ICU
    3. Proper Use of Antibiotics in the Perioperative Period
    4. Enteral Nutrition Therapy in the Surgical Perioperative Period
    5. Specialized Perspectives in ICU Perioperative Nursing
    6. Rehabilitation in the Surgical Perioperative Period

    Specific Topics
    1. Monitoring in the ICU
    2. Evaluation of Portable X-ray Images
    3. Evaluation of Blood and Biochemical Tests
    4. Management of Medication Routes in the ICU
    5. Tips and Key Points for Postoperative Drain Management
    6. Ventricular Drainage and Intracranial Pressure Management
    7. ICU Bedside Echo (POCUS)
    8. Weaning from Mechanical Ventilation
    9. Graphic Monitoring of Mechanical Ventilation
    10. Use of HFNC and NPPV
    11. Blood Pressure Management and Use of Circulatory Drugs
    12. Essentials of Antiarrhythmic Drugs
    13. Management of Intra-Aortic Balloon Pump (IABP)
    14. Tips and Key Points for ECMO
    15. Introduction and Management of Impella®
    16. Acute Blood Purification Therapy in Acute Kidney Injury
    17. Evaluation and Management of Coagulation and Fibrinolysis in the Perioperative Period
    18. Management of Fluid In-Out Balance in the Perioperative Period
    19. Electrolyte Management
    20. Management of Post-ICU Syndrome
    21. PADIS Approach in Surgical Intensive Care — Pain, Sedation, and Delirium Management —

  2. 改訂第6版 救急診療指針 監修 日本救急医学会 Reviewed

    松田直之( Role: Contributor ,  血液・免疫疾患)

    株式会社 へるす出版  2024.4  ( ISBN:978-4-86719-083-8

     More details

    Total pages:1522   Responsible for pages:482-496   Language:Japanese Book type:Textbook, survey, introduction

  3. 集中治療医学 日本集中治療医学会 編 Reviewed

    松田直之( Role: Joint author ,  受容体とシグナル伝達)

    株式会社 Gakken  2023.5  ( ISBN:978-4-05-510024-3

     More details

    Total pages:424   Responsible for pages:32-46   Language:Japanese Book type:Textbook, survey, introduction

  4. 救急・集中治療アドバンス「敗血症〜感染症と臓器障害への対応〜」

    松田直之( Role: Edit ,  編集および執筆)

    株式会社 中山書店,東京  2023.1  ( ISBN:978-4-521-74336-3

     More details

    Total pages:512   Responsible for pages:1-512   Language:Japanese Book type:Textbook, survey, introduction

    1 章 総論
     1-1 敗血症の歴史(丸藤 哲)
     1-2 感染症の歴史(長友安弘,二木芳人)
     1-3 敗血症の病態生理(平澤博之)
     1-4 感染症における自然免疫(保倉祥太,竹内 理)
    2 章 敗血症と感染症の診断
     2-1 敗血症の定義と診断(吉村旬平,梅村 穣,小倉裕司)
     2-2 感染症疾患の定義と診断(藤田次郎)
     2-3 細菌診断におけるグラム染色(朝野和典,濱口重人)
     2-4 微生物診断における特殊検査(奥田菜緒,笠原 敬)
     2-5 感染症と敗血症のバイオマーカー(志馬伸朗)
    3 章 感染症の管理
    [3-1 総論]
     3-1-1 院内感染で注意するべき微生物(中嶋一彦)
     3-1-2 細菌培養検査/薬剤感受性の適正評価(草野展周)
    3-1-3 ドレーンを用いた感染症管理(小林美奈子)
    [3-2 各論]
     3-2-1 ブドウ球菌属:MSSA,MRSA,MRCNS(山本善裕,兼田磨熙杜)
     3-2-2 エンテロコッカス属(土戸康弘,藤田直久)
     3-2-3 クレブシエラ属(岡 祐介,青木洋介)
     3-2-4 アシネトバクター属(萩原真生,山岸由佳,三鴨廣繁)
     3-2-5 緑膿菌(荒川宜親,伊藤亮太)
     3-2-6 エンテロバクター属(詫間隆博,時松一成)
     3-2-7 大腸菌(西 順一郎)
     3-2-8 結核菌(御手洗 聡)
     3-2-9 肺炎球菌(藤田次郎)
     3-2-10 溶血性レンサ球菌(飯沼由嗣)
     3-2-11 レジオネラ属(宮良高維)
     3-2-12 クロストリジウム属(中村 敦)
     3-2-13 ウイルス感染症:COVID-19 を念頭においた対応(関 雅文)
     3-2-14 深在性真菌症(大森慶太郎)
     3-2-15 ダニ媒介感染症(山岸由佳)
    4 章 ベーシック:敗血症性臓器障害の管理
     4-1 日本版敗血症診療ガイドライン(矢田部智昭,西田 修)
     4-2 モニタリング(水口義規,谷口 巧)
     4-3 鎮痛・鎮静・せん妄・睡眠の管理(鶴田良介,藤田 基)
     4-4 ARDS の病態と管理(松田直之)
     4-5 敗血症性ショックの管理:血管障害と心臓障害(松田直之)
     4-6 急性腎障害の管理(齋藤尚二,丸山彰一)
     4-7 播種性血管内凝固の管理(早川峰司)
     4-8 神経・筋障害の管理:PICS への対応(中西信人,井上茂亮)
     4-9 急性期栄養管理(中村謙介,小谷穣治)
     4-10 電解質/内分泌の管理(江木盛時)
     4-11 臨床工学機器の管理(相嶋一登)
     4-12 早期リハビリテーションの実際(髙橋佑太,高橋哲也)
    5 章 アドバンス:敗血症管理の工夫
     5-1 災害時における感染症と敗血症への対応(高野知憲,山﨑行敬,國島広之)
     5-2 敗血症の早期発見のためのシステム(中川 聡)
     5-3 抗菌薬のTDM の工夫(松元一明)
     5-4 敗血症における神経集中治療(黒田泰弘,河北賢哉)
     5-5 敗血症における人工呼吸管理の工夫(木庭 茂,則末泰博)
     5-6 敗血症におけるβ遮断薬の適正使用法(垣花泰之)
     5-7 敗血症における血液浄化法の工夫(森山和広,西田 修)
     5-8 ステロイド療法の工夫(黒田浩光,升田好樹)
     5-9 経腸栄養管理の工夫(佐藤格夫,沖田光雄,小川史朗)
     5-10 ビタミン投与の評価と検討(矢田部智昭)

  5. 救急・集中治療 「重症感染症のすべて —研修医からの質問302—」

    松田直之( Role: Edit ,  全内容)

    株式会社 総合医学社  2023.1  ( ISBN:978-4-88378-577-3

     More details

    Total pages:360   Responsible for pages:1-360   Language:Japanese Book type:Textbook, survey, introduction

    I.総 論
    重症感染症を考える
    感染症パンデミック
    感染症法の概要について
    輸入感染症
    1類感染症の動向と対策
    2類感染症の動向と対策
    人工呼吸器関連肺炎の動向
    カテーテル関連血流感染症の動向

    II.感染症の診断・治療・病態
    予防接種の基本知識
    感染症の問診で気をつけること
    微生物検査方法
    血液培養検査で気をつけること
    遺伝子検査機器による感染症診断
    重症感染症の病理
    アンチバイオグラムの作成と利用
    敗血症の診断で気をつけること
    敗血症の治療で気をつけること
    感染症における補体活性化
    凝固・線溶系異常で気をつけること
    消毒薬の効果と限界
    抗菌薬の選択とPK/PD

    III.各種感染症の管理
    結 核
    肺非結核性抗酸菌症
    肺炎球菌
    髄膜炎菌
    インフルエンザ菌
    肺炎マイコプラズマ
    レジオネラ
    COVID-19に対する感染防御策
    COVID-19の診断と治療
    インフルエンザウイルス
    MSSAとMRSA
    腸球菌属
    クレブシエラ属
    アシネトバクター属
    緑膿菌
    エンテロバクター科
    大腸菌
    溶血性連鎖球菌
    破傷風菌
    Clostridium difficile
    嫌気性菌
    カンジダ属―侵襲性カンジダ感染症―
    アスペルギルス属
    ムーコル症
    梅 毒
    食中毒
    犬咬傷
    ダニ刺症(ダニ媒介感染症)

    IV.これからの重症感染対策
    地域における感染制御支援
    感染管理教育
    抗菌薬療法への薬剤師からの支援
    感染症管理データベース

  6. ER・ICUでの薬の使い方・考え方 — エキスパートが実践する秘訣(コツ)— 2021-'22 Reviewed

    松田直之( Role: Edit)

    総合医学社  2020.10  ( ISBN:9784883785674

     More details

    Total pages:336   Responsible for pages:1-336   Language:Japanese Book type:Textbook, survey, introduction

    内容詳細と執筆担当

    総 論
    Q1 救急・集中治療領域における薬剤の適正使用 松田直之
    Q2 救急・集中治療領域の薬剤の安全管理 曽我弘道,入江利行
    Q3 救急・集中治療領域におけるTDMの役割 高橋佳子
    Q4 救急・集中治療における薬剤師ポジションペーパー 前田幹広

    各論 Ⅰ.中枢関連
    Q5 頭部外傷に対する薬物使用 本多 満
    Q6 脳卒中 山本修輔,黒田 敏
    Q7 痙攣重積・てんかん重積 横堀將司
    Q8 髄膜炎・脳炎 伊藤 悟
    Q9 神経・筋疾患(ギラン・バレー症候群) 小池春樹,勝野雅央

    各論 Ⅱ.呼吸関連
    Q10 市中肺炎/誤嚥性肺炎 進藤有一郎
    Q11 結核 新山 優,細川直登
    Q12 インフルエンザウイルス感染症/COVID-19 倭 正也
    Q13 ARDS  丸山一男,丸山淳子,今井 寛
    Q14 慢性閉塞性肺疾患 亀之原佑介,町田健太朗,井上博雅
    Q15 間質性肺炎 近藤康博

    各論 Ⅲ.循環関連
    Q16 心肺停止 山畑佳篤
    Q17 うっ血性心不全 平敷安希博
    Q18 アナフィラキシー/アナフィラキシーショック 永田 真,正木健司
    Q19 急性心筋梗塞 杉﨑陽一郎,山本 剛
    Q20 感染性心内膜炎 天野雅史,泉 知里
    Q21 不整脈 油井慶晃,佐藤直樹
    Q22 肺高血圧症 中野嘉久,近藤隆久
    Q23 深部静脈血栓症 舘野丈太郎,小倉裕司

    各論 Ⅳ.腎臓関連
    Q24 急性腎障害(AKI) 鷺島克之

    各論 Ⅴ.消化器関連
    Q25 急性肝炎/急性肝不全(劇症肝炎,遅発性肝不全)  中山伸朗
    Q26 急性膵炎 真弓俊彦,石川成人
    Q27 胃十二指腸潰瘍 松本憲明,篠塚 健,大鶴 繁
    Q28 炎症性腸疾患 松下正伸,中村正直,藤城光弘

    各論 Ⅵ.血液凝固・線溶関連
    Q29 外傷における血液凝固・線溶系の管理 久志本成樹,山本圭祐,遠藤 成
    Q30 播種性血管内凝固(DIC) 山川一馬
    Q31 溶血性尿毒症症候群 渡邉栄三
    Q32 ヘパリン起因性血小板減少症 釈永清志
    各論 Ⅶ.内分泌・代謝・電解質関連
    Q33 抗利尿ホルモン不適合分泌症候群(SIADH)  萩原大輔,有馬 寛
    Q34 甲状腺クリーゼ/甲状腺機能亢進症 赤水尚史
    Q35 副甲状腺機能亢進症/副甲状腺機能低下症 野津雅和,山内美香
    Q36 副腎皮質機能低下症(副腎クリーゼを含む) 坂本竜一,小川佳宏
    Q37 糖尿病性ケトアシドーシス/高血糖性高浸透圧症候群 清水敬樹
    Q38 高ナトリウム血症/低ナトリウム血症 猪谷哲司,寺田典生
    Q39 高カリウム血症/低カリウム血症 宮川泰宏
    各論 Ⅷ.精神関連
    Q40 集中治療領域の鎮静・鎮痛・せん妄・睡眠の管理 中原貴志,鶴田良介
    Q41 急性薬物中毒 山口 均
    各論 Ⅸ.小児関連
    Q42 小児集中治療 内田 要,松井彦郎
    各論 Ⅹ.感染症関連
    Q43 MRSA/MSSA/MRCNSに対する抗菌薬治療 植田貴史,竹末芳生
    Q44 多剤耐性グラム陰性菌に対する抗菌薬治療 福井康貴,川筋仁史,山本善裕
    Q45 嫌気性菌に対する抗菌薬治療 萩原真生,山岸由佳,三鴨廣繁
    Q46 クロストリジウム感染症 久保有子,大毛宏喜
    Q47 真菌感染症に関する抗真菌薬治療 田代将人,泉川公一

  7. 救急・集中治療アドバンス「急性循環不全」

    松田直之( Role: Joint editor ,  急性循環不全の病態)

    株式会社 中山書店  2019.5  ( ISBN:978-4-521-74335-6

     More details

    Total pages:344   Language:Japanese Book type:Textbook, survey, introduction

    1章 定義と診断
     1-1 循環不全の定義と診断 (橋本壮志,天谷文昌)
      1 循環の生理学的意義
      2 循環不全ならびにショックの定義
      3 ショックの定義の変遷
      4 循環不全の診断
     1-2 急性循環不全の病態 (松田直之)
      1 急性循環不全の病態の基本
      2 急性循環不全を誘導する4つの病態
      3 ずり応力に依存した血管径調節作用
      4 急性循環不全における虚血領域の血管拡張反応の病態
      5 急性循環不全における心機能抑制の病態
      6 急性循環不全に随伴する全身性病態
       Column Na+-Ca2+交換系(NCX)
     1-3 急性循環不全の重症度評価(高橋一則,中根正樹)
      1 初期評価
      2 それぞれの病態に対する重症度評価
       Column ショック症状をきたさない低血圧

    2章 診断補助
     2-1 モニタリング総論 (森松博史,松﨑 孝,廣井一正)
      1 画像診断
      2 生理学的検査/血液検査
      3 血管内デバイス
     2-2 胸部X線 (立木規与秀,安宅一晃)
      1 臥位撮影での注意点
      2 心原性における所見
      3 循環血液量減少性における所見
      4 閉塞性における所見
     2-3 心電図 (水野裕八)
      1 モニター誘導と標準12誘導
      2 基本パラメータの把握
      3 緊張性の高い心電図と注意すべき心電図変化
      4 注意すべき心電図
      5 心電図に影響を与えうる病態
       Column Cabrera forma
       Column 12誘導心電図から心室性不整脈の起源を同定する
     2-4 血液ガス分析 (藤野裕士)
      1 血液ガス分析の実際
      2 体外循環におけるPaCO2管理
     2-5 心エコー (山田 聡)
      1 心エコー法の役割
      2 左室収縮機能と1回拍出量の評価
      3 左室拡張機能と左室充満圧の評価
       Advice 初期の心エコー検査の適応
       Topics ASEによる左室拡張機能評価のアルゴリズム
     2-6 CT (小山靖史,林 祐作)
      1 CT検査で行うtriple rule out
      2 急性大動脈解離の診断
      3 急性肺血栓塞栓症の診断
      4 急性心筋梗塞の診断
     2-7 心臓カテーテル検査 (小林欣夫,立石和也)
      1 冠動脈造影検査
      2 右心カテーテル検査
      3 心筋生検
       Column door-to-balloon time
       Column 抗血小板薬のローディング
       Column CULPRIT-SHOCK 試験
     2-8 バイオマーカー (佐藤幸人)
      1 心筋梗塞診断における心筋トロポニンT,心筋トロポニンI測定
      2 急性心不全診断におけるBNP,NT-proBNP測定
      3 肺動脈血栓塞栓症診断におけるD-ダイマー測定
      4 急性心不全の治療経過におけるバイオマーカーの推移
       Advice バイオマーカーの一般的注意
     2-9 心拍出量モニター (小竹良文)
      1 急性循環不全の原因鑑別とモニタリング
      2 動脈圧波形解析法の原理
      3 酸素需給バランスの指標としての静脈血酸素飽和度
      4 モニターから得られる指標に基づいた輸液蘇生
       Topics プロトコール化された輸液蘇生
       Column 肺動脈カテーテル
       Topics 呼気終末閉塞テスト

    3章 症状・疾患における病態と治療
    [1.ショック]
     3-1-1 閉塞性・拘束性ショック (京 道人,志馬伸朗)
      1 定義
      2 閉塞性・拘束性ショックの病態
      3 閉塞性・拘束性ショックの身体所見
      4 閉塞性・拘束性ショックの検査所見
      5 鑑別
      6 閉塞性・拘束性ショックの治療
       Column 肺血栓塞栓症の否定
     3-1-2 出血性ショック (浅香葉子,瀬尾龍太郎)
      1 定義
      2 出血性ショックの身体所見
      3 出血性ショックの検査所見
      4 鑑別,原因疾患
      5 出血性ショックの治療
       Topics トロンボエラストグラフィー(TEGR),トロンボエラストメトリー(ROTEMR)
     3-1-3 心原性ショック (大塚将秀)
      1 定義
      2 心原性ショックの病態
      3 心原性ショックの身体所見
      4 心原性ショックの検査所見
      5 鑑別
      6 心原性ショックの原因疾患
      7 心原性ショックの治療
     3-1-4 敗血症性ショック (赤塚正幸,升田好樹)
      1 敗血症性ショックの病態
      2 敗血症性ショックの治療
      3 今後の展望
     3-1-5 アナフィラキシーショック (大藤 純)
      1 定義と診断基準
      2 アナフィラキシーショックの病態生理
      3 アナフィラキシーショックの身体所見
      4 アナフィラキシーショックの検査所見
      5 アナフィラキシーショックの治療
      6 症例提示
       Column Kounis症候群
       Column Bezold-Jarisch反射
     3-1-6 神経原性ショック (土井賢治,武居哲洋)
      1 定義
      2 神経原性ショックの病態
      3 神経原性ショックの原因
      4 神経原性ショックの診断
      5 神経原性ショックの治療
     3-1-7 産科ショック (安田則久,後藤孝治)
      1 産科ショックと妊産婦死亡の発生状況
      2 産科ショックをきたす疾患
      3 産科DIC
      4 産科危機的出血への対応
     3-1-8 内分泌疾患によるショック (高橋 完)
      1 甲状腺クリーゼ
      2 粘液水腫性昏睡
      3 急性副腎不全(副腎クリーゼ)
      4 高血糖緊急症
       Column 副腎クリーゼと胃腸炎
     [2.重症心疾患]
     3-2-1 虚血性心疾患 (澤田賢一郎,川上将司,安田 聡)
      1 急性冠症候群
      2 心原性ショックを合併する急性冠症候群
      3 急性心筋梗塞に合併する機械的合併症
      4 右室梗塞
       Column PCI vs CABG
       Column 肺動脈カテーテル
     3-2-2 非虚血性心筋症 (坂田泰史,余西智香)
      1 主な非虚血性心筋症
      2 非虚血性心筋症の診断
      3 非虚血性心筋症の治療
     3-2-3 重症不整脈 (野上昭彦)
      1 重症心室性不整脈の病態
      2 重症心室性不整脈の検査
      3 重症心室性不整脈の治療
       Column アブレーション施行群と非施行群の無作為化比較試験
     3-2-4 劇症型心筋炎 (猪又孝元)
      1 劇症型心筋炎の病態
      2 劇症型心筋炎の診断
      3 劇症型心筋炎の治療
       Column 心筋炎の定義と疾患概念のズレ
     3-2-5 たこつぼ症候群 (明石嘉浩)
      1 たこつぼ症候群の診断基準
      2 たこつぼ症候群の病態
      3 たこつぼ症候群の症状と検査所見
      4 たこつぼ症候群の治療
      5 たこつぼ症候群の予後

    4章 治療選択
     4-1 呼吸管理 (内山昭則)
      1 右心機能と呼吸
      2 陽圧換気と胸腔内圧
      3 肺水腫とPEEP
      4 左心不全とPEEP
      5 非侵襲的陽圧換気(NPPV)
      6 侵襲的呼吸管理
      7 換気量の設定をどうするか?:肺保護換気について
      8 人工呼吸からのウィーニングと循環
     4-2 カテコラミン (松本聡治朗,原 哲也)
      1 カテコラミンの生合成および代謝
      2 カテコラミンの生理作用
      3 各種カテコラミン
      4 薬物-受容体相互作用
      5 PDE-III阻害薬
       Column カテコラミンとPDE-III阻害薬
     4-3 輸液療法 (渡邉誠之,讃井將満)
      1 初期輸液の考え方
      2 輸液製剤の選択
      3 輸液の生理学
      4 輸液方法
     4-4 IABP:導入と管理のポイント (那須崇人,森野禎浩)
      1 背景
      2 IABPの原理
      3 IABPの導入:適応
      4 IABPの禁忌
      5 管理上のポイント
      6 IABPの離脱
     4-5 ECMO:導入と管理のポイント (竹田晋浩,大山慶介)
      1 ECMOの適応
      2 VA-ECMOの導入方法
      3 導入時の3段階
      4 導入後
      5 VA-ECMO特有の合併症
      6 離脱
      7 IMPELLA
       Topics PCPSとVA-ECMO
       Column Dirty double
       Column 鼠径部の穿刺
       Column 各社カニューレの特徴
     4-6 補助人工心臓:導入と管理のポイント (絹川弘一郎)
      1 体外設置型VADの適応
      2 体外設置型VAD挿入後の予防的管理
      3 心機能回復への試み
       Column LVAD装着後のリバースリモデリングとは?
     4-7 一時ペーシングとペースメーカー植込み (石川利之)
      1 一時ペーシング
      2 永久ペースメーカー植込み
       Column 生理的ペースメーカーと非生理的ペースメーカー
     4-8 植込み型除細動器(ICD)・着用型自動除細動器(WCD) (庭野慎一)
      1 器質的疾患を有する症例の突然死リスクとICD
      2 急性期病態における突然死リスクと除細動デバイス
      3 着用型自動除細動器(WCD)とその適応
       Column 突然死の一次予防と二次予防の疫学
       Column 心筋梗塞発症後早期のICD使用
     4-9 輸血 (大田典之)
      1 輸血の危険性
      2 restrictive strategy(制限輸血),liberal strategy(非制限輸血)の是非
      3 大量輸血
     4-10 利尿薬 (内田篤治郎)
      1 ループ利尿薬
      2 抗アルドステロン薬
      3 サイアザイド系利尿薬
      4 ヒト心房性ナトリウム利尿ペプチド(hANP)
       Column 利尿薬への抵抗性を形成する要因
       Topics 敗血症における急性腎障害とバソプレシン
     4-11 心筋保護薬 (奥村貴裕)
      1 心筋保護薬とは
      2 左室駆出率からみた心不全の分類とリバースリモデリング
      3 心筋保護薬のエビデンス
      4 服薬遵守の重要性
      5 心筋保護薬使用のタイミング,コツとピットフォール
      6 HFpEFに対する心筋保護薬のエビデンス
     4-12 抗血小板薬・抗凝固薬 (奥山裕司)
      1 抗血小板薬・抗凝固薬の作用機序
      2 急性循環不全を呈する病態での使用法
      3 抗血小板薬・抗凝固薬内服中の出血への対処法
     4-13 抗不整脈薬 (池田隆徳)
      1 抗不整脈薬の分類と種類
      2 抗不整脈薬の作用機転
      3 抗不整脈薬の使用目的
      4 抗不整脈薬の適応疾患
      5 各薬剤の使用ポイント
      6 併用療法
      7 抗不整脈薬の副作用
      8 禁忌疾患
       Column Naチャネル遮断薬とKチャネル遮断薬の作用の違い
       Column 発作性心房細動に対する停止法としての“pill-in-the-pocket”
       Advice 抗不整脈薬の排泄経路と主な副作用
     4-14 ステロイド (江木盛時)
      1 急性循環不全におけるステロイド
      2 敗血症に対するステロイド療法
      3 敗血症性ショック患者すべてにステロイドを使用すべきか?
      4 敗血症性ショックに対するステロイド投与に関し不明確な事項

  8. 救急・集中治療アドバンス「急性肝不全・急性腎障害・代謝異常」 Reviewed

    松田直之( Role: Joint editor ,  糖尿病:急性期血糖管理)

    株式会社 中山書店  2018.2  ( ISBN: 978-4-521-74334-9

     More details

    Total pages:312   Responsible for pages:235-244   Language:Japanese Book type:Textbook, survey, introduction

    1章 急性肝不全の病態
     1-1 劇症肝炎 (徳田賢太郎)
      1 劇症肝炎の定義,診断基準
      2 劇症肝炎の成因
      3 劇症肝炎発症のメカニズム
      4 劇症肝炎の臨床像
      5 劇症肝炎の管理
     1-2 ウイルス性肝炎 (田村純人)
      1 ウイルス性肝炎の疫学
      2 ウイルス性肝炎の診断
      3 ウイルス性肝炎の臨床症状
      4 臨床検査
      5 鑑別診断
      6 治療
      7 肝炎ウイルス感染による肝炎
      8 肝炎ウイルス以外のウイルス感染による肝機能障害
     1-3 薬物性肝障害 (池田房雄)
      1 薬物性肝障害の起因薬物
      2 薬物性肝障害の発症機序
      3 薬物性肝障害の診断
      4 薬物性肝障害の病理所見
      5 薬物性肝障害の治療
     1-4 術後肝不全 (永山 稔,竹政伊知朗)
      1 術後肝不全の病態
      2 術後肝不全の定義
      3 術後肝不全を予防する対策
      4 術後肝不全に対する治療
     1-5 肝機能評価 (篠田昌宏,黒田達夫,北川雄光)
      1 肝機能に関連する血液検査
      2 肝機能評価に用いられる画像検査
      3 肝予備能評価法
      4 慢性・急性肝不全別の肝機能評価
      5 今後の課題

    2章 急性肝不全の治療
     2-1 急性肝不全に対する薬物療法 (松﨑 孝,森松博史)
      1 急性肝不全の分類
      2 急性肝不全の診断と治療
      3 急性肝不全における臓器別の臨床症状と対処法
      4 劇症肝炎の薬物療法:病態からのアプローチ
      5 急性肝不全の薬物療法:臓器障害の観点から
     2-2 急性肝不全に対する人工肝補助療法(ALS) (今泉 均)
      1 ALSの目的
      2 on-line HDF,high flow CHDFの役割
      3 血漿交換(PE)の役割
      4 急性肝不全に対するALSの実際
      5 ALSの限界と今後の展望
     2-3 急性肝不全に対する肝移植 (篠田昌宏,黒田達夫,北川雄光)
      1 急性肝不全に対する肝移植
      2 肝移植の実際:症例提示
      3 急性肝不全に対するABO血液型不適合成人生体肝移植
      4 今後の課題

    3章 急性腎傷害の定義・診断
     3-1 急性腎傷害(AKI)の定義 (高折佳央梨,内野滋彦)
      1 歴史的背景:RIFLE分類,AKIN分類,KDIGO分類
      2 sCrおよび尿量によるAKI定義の現状
      3 今後の課題
     3-2 AKIの病因分類 (松浦 亮,野入英世)
      1 AKIの病因
      2 腎前性AKI
      3 腎性AKI
      4 腎後性AKI
     3-3 AKIのバイオマーカー (森 潔)
      1 代表的なAKIのバイオマーカー
      2 バイオマーカーによるAKIの早期診断
      3 バイオマーカーによるAKIの重症度および生命予後の予測
      4 臨床介入試験へのAKIバイオマーカーの応用
      5 今後の課題
     3-4 AKI診療ガイドラインのポイント (堀野太郎,寺田典生)
      1 日本版AKI診療ガイドライン作成までの経緯
      2 各章(CQ)のポイント

    4章 急性腎傷害の治療
     4-1 AKIに対する血液浄化法の考え方 (森山和広,西田 修)
      1 血液浄化法の基礎知識
      2 CH(D)Fによるサイトカインの除去
      3 CH(D)F中の抗菌薬投与の基本的考え方
      4 CH(D)F中の栄養成分の喪失と投与量の基本的考え方
     4-2 AKIに対する血液浄化療法の開始と中止 (清水一好,森松博史)
      1 現行のガイドライン
      2 開始基準
      3 中止基準
     4-3 AKIに対する血液浄化療法の浄化量 (村田真理絵,長谷川正宇,河原﨑宏雄)
      1 血液浄化療法における浄化量とは
      2 浄化量とAKIの予後の関係
      3 日本における浄化量
     4-4 特殊な腎代替療法-小児の血液透析と腹膜透析 (小椋雅夫,石倉健司)
      1 小児の特殊性
      2 急性血液浄化療法の適応
      3 小児における血液透析
      4 小児における腹膜透析
     4-5 AKI患者の栄養管理 (矢田部智昭)
      1 集中治療患者における栄養管理
      2 AKI患者の栄養管理
      3 集中治療患者における血糖管理
     4-6 AKIにおける利尿薬の投与 (土井研人)
      1 尿量減少とAKI
      2 AKIにおける体液過剰
      3 AKIにおける利尿薬投与の是非
      4 ループ利尿薬
      5 ヒト心房性ナトリウム利尿ペプチド(hANP)
     4-7 AKIに対する血管作動薬の効果 (小坂順子,森松博史)
      1 ドパミン
      2 ノルアドレナリン
      3 バソプレシン
     4-8 小児におけるAKI (綾 邦彦)
      1 小児AKIの疫学
      2 小児AKIの診断
      3 小児AKIの治療
     4-9 高齢者におけるAKI (佐々木 環,城所研吾)
      1 高齢者におけるAKIの疫学
      2 加齢による腎臓の変化
      3 高齢者におけるAKIの原因
      4 高齢者におけるAKIの診断:AKIの臨床経過の把握
      5 高齢者におけるAKIの短期予後と回復後の経過
      6 高齢者AKIの治療戦略
      7 治療の倫理的側面と問題
      8 今後の課題

    5章 電解質・代謝異常
     5-1 ナトリウム異常 (行岡秀和)
      1 低ナトリウム血症(hyponatremia)
      2 高ナトリウム血症(hypernatremia)
     5-2 カリウム異常 (岡元和文)
      1 低カリウム血症(hypokalemia)
      2 高カリウム血症(hyperkalemia)
     5-3 糖尿病:急性期血糖管理 (松田直之)
      1 糖尿病管理の概念
      2 糖尿病の定義と診断
      3 糖尿病に合併する病態のモニタリング
      4 救急・集中治療領域における急性期血糖コントロール
     5-4 急性副腎不全(副腎クリーゼ) (江島 豊)
      1 副腎と視床下部-下垂体-副腎系
      2 糖質コルチコイド(GC)産生と代謝
      3 重症疾患時のHPA系
      4 炎症に関連するGC作用分子メカニズム
      5 副腎不全(AI)の一般的な原因分類
      6 重症疾患における副腎不全
      7 副腎不全の診断
      8 治療

    6章 酸塩基平衡異常
     6-1 重炭酸アプローチ (小竹良文)
      1 酸塩基平衡異常の解釈
      2 重炭酸アプローチに基づいた酸塩基平衡の評価法
     6-2 base excessアプローチ (井上敬太,内藤慶史,佐和貞治)
      1 base excessアプローチ以前の概念
      2 base excessアプローチの実際
     6-3 Stewartアプローチ (木村 聡,森松博史)
      1 概念
      2 strong ion difference(SID)
      3 ATOT
      4 SIDaとSIDe
      5 strong ion gap(SIG)
      6 pHの決定因子のまとめ

  9. Advances in Emergency and Intensive Care Medicine: Inflammation and coagulation/fibrinolysis in critically ill patients

    Naoyuki Matsuda( Role: Edit)

    2017.3  ( ISBN:978-4-521-74333-2

     More details

    Total pages:336   Responsible for pages:1-336   Language:Japanese Book type:Textbook, survey, introduction

    Chapter 1: Overview

    1-1: The relationship between inflammation, coagulation, and fibrinolysis in the field of emergency and intensive care

    Chapter 2: Definition and diagnosis of inflammation, coagulation, and fibrinolysis

    2-1: Definition and diagnosis of systemic inflammatory response syndrome

    [Definition and diagnosis of DIC]

    2-2: Diagnostic criteria for acute DIC

    2-3: (Former) Ministry of Health, Labor, and Welfare diagnostic criteria for DIC

    2-4: ISTH DIC diagnostic criteria

    2-5 Obstetric DIC diagnostic criteria

    2-6 Neonatal DIC diagnostic criteria

    Chapter 3 Inflammation and coagulation/fibrinolysis markers

    3-1 White blood cells

    3-2 CRP

    3-3 Inflammatory cytokines

    3-4 Proliferative cytokines

    3-5 Coagulation system tests and molecular markers

    3-6 Fibrinolysis system tests and molecular markers

    3-7 Procalcitonin

    3-8 Presepsin

    3-9 Fibrinogen, platelets

    3-10 PT, APTT, TT

    3-11 Endogenous proteases

    Chapter 4 Association with underlying diseases

    4-1 Sepsis

    4-2 Trauma

    4-3 Burns 4-4 Heat stroke
    4-5 Malignant tumors
    4-6 Obstetric diseases
    4-7 Neonates
    Chapter 5 Treatment
    5-1 Sepsis treatment guidelines
    5-2 Antithrombin concentrates
    5-3 Thrombomodulin
    5-4 Synthetic protease inhibitors
    5-5 Heparins
    Chapter 6 Important differential diagnoses
    6-1 Thrombotic microangiopathy
    6-2 Thrombotic thrombocytopenic purpura
    6-3 Hemolytic uremic syndrome
    6-4 HELLP syndrome
    6-5 Antiphospholipid syndrome
    6-6 Hemophagocytic lymphohistiocytosis
    6-7 Heparin-induced thrombocytopenia

  10. ICU・救急ナース松田塾 呼吸と循環に強くなる!

    松田直之( Role: Sole author)

    株式会社Gakken  2016.9  ( ISBN:9784780911077

     More details

    Total pages:162   Book type:Textbook, survey, introduction

  11. 救急・集中治療アドバンス「急性呼吸不全」 Reviewed

    松田直之( Role: Joint editor ,  ステロイド療法)

    株式会社 中山書店  2016.4  ( ISBN:978-4-521-74332-5

     More details

    Total pages:336   Responsible for pages:290-294   Language:Japanese Book type:Textbook, survey, introduction

  12. 標準救急医学第5版 日本救急医学会編 生体侵襲 Reviewed

    松田直之( Role: Contributor ,  生体侵襲と生体反応)

    医学書院  2014.1  ( ISBN:978-4-260-01755-8

     More details

    Total pages:520   Responsible for pages:221-225   Language:Japanese Book type:Textbook, survey, introduction

  13. 救急・集中治療「生体侵襲と臓器管理」

    松田直之(編集・執筆)

    総合医学社,東京  2008.11  ( ISBN:9784883782956

     More details

    Language:Japanese Book type:Scholarly book

  14. 呼吸器疾患 Clinical-Radiological-Pathological アプローチ Reviewed

    松田直之( Role: Contributor ,  急性呼吸不全とALI/ARDS)

    株式会社 南江堂  2017.3  ( ISBN:978-4-524-25964-9

     More details

    Total pages:280   Responsible for pages:36-40   Language:Japanese Book type:Textbook, survey, introduction

  15. 心臓血管手術周術期管理のすべて

    松田直之( Role: Contributor ,  Minitracheostomy 吸痰吸引キットをいつどう使うか?)

    株式会社 メジカルビュー社,東京  2023.3  ( ISBN:978-4-7583-2206-5

     More details

    Total pages:656   Responsible for pages:242-246   Language:Japanese Book type:Textbook, survey, introduction

    Ⅰ 総論
     1 国内における心臓血管手術の件数と短期死亡率(日本胸部外科学会および日本血管外科学会の公開資料)  [一原直昭,宮田裕章,國原 孝]
     2 術前
      ① 術前評価とその意義  [伊藤丈二]
      ② 術前評価とその対策  [佐々木健一]
      ③ 血液・血漿分画製剤の準備  [岩朝静子]
      ④ 再手術における評価と対策  [佐々木健一]
     【One Point Advice】
      ① インフォームドコンセント  [山口敦司]
      ② 手術医療分野での医療安全に関する最近の話題(ハイリスクカンファレンスと医療事故調査制度)  [ 小池正嘉,三尾 寧]
      ③ 循環器疾患と睡眠時無呼吸症候群  [末松義弘]
     3 術中
      ① 最新の心臓麻酔:各種モニタリング  [安田篤史,澤村成史]
      ② 最新の心臓麻酔:硬膜外麻酔,スパイナルドレナージと抗凝固,抗血小板療法  [柿沼玲史,澤村成史]
      ③ 緊急手術とCPR,IABP,Impella®,PCPS/V–A ECMO  [中田 淳,山本 剛]
      ④ 人工心肺回路  [室岡諭岐,吉田雅人]
      ⑤ 心筋保護  [阿部貴行]
     4 術後早期
      ①-1 術後管理(ICU)  [伊藤雄二郎]
      ①-2 術後管理(一般病棟)  [吉野邦彦]
      ② 術後疼痛管理  [井上莊一郎,小幡由美]
      ③ 鎮静,せん妄管理  [榎本貴一,岡村 誉]
      ④ 腎不全・透析患者の術前・術中・術後管理  [津久井宏行]
      ⑤ 術後不整脈に対する対策と抗不整脈薬の使用法  [有田卓人,大塚崇之]
      ⑥-1 medication の最新エビデンス:利尿薬以外  [田邉健吾]
      ⑥-2 medication の最新エビデンス:利尿薬  [瀬在 明]
     5 術後後期
      ① 心臓リハビリテーション  [櫻田弘治,加藤祐子]
      ② 心臓血管手術と認知機能  [前川謙悟]
      ③ 補助換気療法  [田代尚範]
     6 周術期栄養管理と栄養指導  [松元紀子]
     【One Point Advice】
      ④ 術中経食道心エコー検査(TEE)  [清野雄介]
      ⑤ 感染と抗菌薬の使い方  [狩野惠彦]
      ⑥ 術後創感染  [藤原 修]
      ⑦ 術後DVT 予防  [辻 明宏,中西宣文]
      ⑧ ヘパリン起因性血小板減少症  [本橋慎也]
      ⑨ 嚥下  [稲本陽子]
      ⑩ 周術期口腔ケア  [伊東令華]
      ⑪ 緩和医療  [中川俊一]
      ⑫ HFNC とNPPV,どっちがいいの?  [前田 隼,齋藤敬太]
      ⑬ minitracheostomy:喀痰吸引キットをいつ,どう使うか?  [松田直之]
      ⑭ 心臓血管手術後の緊急CPR  [森川大樹,平岡栄治]
      ⑮ スパイナルドレナージ  [大谷将之,齋木佳克]

    Ⅱ 各論
     1 弁膜症
      ① 大動脈弁狭窄症に対する大動脈弁置換術  [阿部恒平]
      ② 大動脈弁狭窄症に対するTAVI  [阿佐美匡彦]
      ③ 大動脈弁閉鎖不全症に対する大動脈弁形成術  [國原 孝]
      ④ 僧帽弁狭窄症に対する僧帽弁置換術  [竹谷 剛]
      ⑤ 僧帽弁閉鎖不全症に対する僧帽弁形成術  [田端 実]
      ⑥ 三尖弁閉鎖不全症に対する三尖弁形成術  [山口裕己]
      ⑦ 胸腔鏡下心臓手術(MICS)  [岡本一真]
      ⑧ 感染性心内膜炎における手術のタイミング  [田口駿介,三浦 崇,江石清行]
     【One Point Advice】
      ⑯ SAM を防ぐには?  [真鍋 晋]
      ⑰ PPM を防ぐには?  [渡邊 隼]
      ⑱ MAC への対策  [柴田利彦]
      ⑲ 僧帽弁閉鎖不全症に対するMitraClip®  [森川喬生]
      ⑳ 心房性機能性僧帽弁閉鎖不全症とは?  [高橋洋介]
     2 虚血性心疾患
      ① conventional CABG  [関 雅浩]
      ② OPCAB(off–pump CABG)  [大野貴之]
      ③ MICS CABG  [菊地慶太]
      ④ グラフトの評価と採取  [松山重文]
      ⑤ 急性心筋梗塞の合併症に対する手術  [木下 武,浅井 徹]
      ⑥ 虚血性心筋症に対する手術  [松浦 馨]
     【One Point Advice】
      ㉑ total arterial revascularization って本当にいいの?(Pros)  [鈴木友彰]
      ㉒ total arterial revascularization って本当にいいの?(Cons)  [伊藤敏明]
      ㉓ endarterectomy  [北本昌平,高梨秀一郎]
      ㉔ proximal anastomosis device  [西田秀史]
     3 大動脈疾患
      ① 大動脈基部置換術・自己弁温存基部置換術  [國原 孝]
      ② 上行・弓部大動脈瘤  [大坪 諭]
      ③ 胸部下行・胸腹部大動脈手術  [志水秀行,飯田泰功]
      ④ 腹部大動脈瘤  [藤村直樹]
      ⑤ 大動脈緊急症  [吉武明弘]
      ⑥ ステントグラフト治療の周術期管理  [馬場 健,宿澤孝太,大木隆生]
     【One Point Advice】
      ㉕ 大動脈炎症候群  [荻野 均]
      ㉖ Marfan 症候群  [縄田 寛]
      ㉗ B型解離後リハビリテーション  [新野哲也]
      ㉘ 急性大動脈スーパーネットワークから学んだこと  [髙橋寿由樹]
     4 心房細動に対するMaze 手術  [石井庸介]
     5 肥大型心筋症
      中隔心筋切除術/肥大型心筋症修復術  [清水 篤,高梨秀一郎]
     6 拡張型心筋症  [松居喜郎]
     7 左心補助人工心臓(LVAD),心臓移植  [井口篤志,新浪博士]
     8 急性肺塞栓症  [山本 剛]
     9 慢性血栓塞栓性肺高血圧症  [島原佑介]
     10 心臓腫瘍  [和田有子]
     11 心膜疾患,拡張障害  [西畑庸介,玉木理仁]
     12 成人先天性心疾患  [平田康隆]
     【One Point Advice】
      ㉙ 左心耳切除術  [遠藤大介,田端 実]

  16. 日本集中治療医学会専門医テキスト  日本集中治療医学会 編 Reviewed

    松田直之( Role: Contributor ,  感染の基礎)

    2015.3  ( ISBN:978-4-88378-850-7

     More details

    Total pages:20150304   Responsible for pages:665-682   Language:Japanese Book type:Textbook, survey, introduction

  17. 標準救急医学第5版 日本救急医学会編 敗血症 Reviewed

    松田直之( Role: Contributor ,  敗血症)

    医学書院  2014.1  ( ISBN:978-4-260-01755-8

     More details

    Total pages:520   Responsible for pages:292-299   Language:Japanese Book type:Textbook, survey, introduction

  18. 標準麻酔科学 第6版 Reviewed

    松田直之( Role: Contributor ,  麻酔科医に必要な救急医学と集中治療医学の知識)

    医学書院  2011.4  ( ISBN:978-4-260-01179-2

     More details

    Total pages:376   Language:Japanese Book type:Textbook, survey, introduction

  19. 改訂第3版 脳神経外科救急ハンドブック 日本脳神経外科救急学会編

    松田直之( Role: Contributor ,  中枢神経系感染症)

    株式会社 メディカ出版  2024.10  ( ISBN: 4-8404-8525-9

     More details

    Total pages:368   Responsible for pages:288-292   Language:Japanese Book type:Textbook, survey, introduction

  20. 救急・集中治療 最新ガイドライン 2024-'25

    松田直之( Role: Joint author ,  成人の敗血症/敗血症性ショックの診療指針)

    株式会社 総合医学社  2024.3  ( ISBN:978-4-88378-478-3

     More details

    Total pages:440   Responsible for pages:80-86   Language:Japanese Book type:Textbook, survey, introduction

    敗血症および敗血症性ショックの診療ガイドラインと診療指針を解説している。

  21. 今日の治療指針 2024

    松田直之(救急医療における感染防御対策)

    株式会社 医学書院  2024.1  ( ISBN:978-4-260-05342-6

     More details

    Total pages:2224   Responsible for pages:118-120   Language:Japanese Book type:Textbook, survey, introduction

  22. 麻酔科プラクティス 8「麻酔管理の疑問に答える生理学」 Reviewed

    松田直之( Role: Contributor ,  高血糖にはどのような有害作用があるのか?)

    株式会社 文光堂  2023.5  ( ISBN:978-4-8306-2855-9

     More details

    Total pages:304   Responsible for pages:192-200   Language:Japanese Book type:Textbook, survey, introduction

  23. 心臓血管手術周術期管理のすべて

    松田直之( Role: Contributor ,  Minitracheostomy 吸痰吸引キットをいつどう使うか?)

    株式会社 メジカルビュー社  2023.3  ( ISBN:ISBN978-4-7583-2206-5

     More details

    Total pages:656   Responsible for pages:242-246   Language:Japanese Book type:Textbook, survey, introduction

  24. 麻酔科トラブルシューティング A to Z

    松田直之( Role: Joint author ,  敗血症)

    株式会社 文光堂  2022.11  ( ISBN:978-4-8306-2853-5

     More details

    Language:Japanese Book type:Textbook, survey, introduction

  25. 救急・集中治療. 最新ガイドライン 2022-'23.

    松田直之( Role: Joint editor)

    総合医学社  2022.9  ( ISBN:978-4-88378-725-8

  26. 救急・集中治療 最新ガイドライン 2022-'23

    松田直之( Role: Joint editor ,  成人の敗血症・敗血症性ショック)

    株式会社 総合医学  2022.3  ( ISBN:978-4-88378-725-8

     More details

    Total pages:500   Responsible for pages:1-500   Language:Japanese Book type:Textbook, survey, introduction

    I.緊急処置・蘇生・手技

    気道確保困難症の指針
    応急手当(first aid)の指針
    成人の一次救命処置(BLS)の指針(窒息を除く)
    自動体外式除細動器(AED),除細動の指針
    成人の二次救命処置(ALS)の指針
    小児の一次救命処置(PBLS)の指針
    小児の二次救命処置(PALS)の指針
    新生児心肺蘇生の指針
    心停止後症候群患者に対する体温管理療法の指針
    蘇生後の全身管理の指針
    ウツタイン様式(病院外心停止事例の記録様式の統一)
    胸腔ドレーン挿入と感染予防の指針
    中心静脈ラインに関する感染対策の指針
    肺動脈カテーテルの挿入指針
    高気圧酸素治療の指針
    血液製剤の使用および輸血療法の実施指針
    危機的出血対応の指針(産科を含む)
    播種性血管内凝固症候群(DIC)の治療指針
    ヘパリン起因性血小板減少症(HIT)の指針
    II.救急外来(ER)での対応

    雷鳴頭痛患者の指針
    失神患者の指針
    心筋梗塞が疑われる患者の指針
    てんかん患者の指針
    腰痛患者の診療指針
    外傷の初期診療指針
    III.ショックの治療

    成人の敗血症/敗血症性ショックの診療指針
    小児・新生児の敗血症性ショックの治療指針
    アナフィラキシーショックの指針
    心原性ショックの治療指針
    急性期心原性ショックの治療指針
    外傷後の大量出血・凝固障害に対する治療ガイドライン
    IV.外傷・熱傷の診断・治療

    外傷による心停止の管理指針
    頭部外傷の治療指針
    肺挫傷の治療指針
    鈍的腹部外傷の治療指針
    肝・脾損傷の治療指針
    膵損傷の治療指針
    腎損傷・膀胱損傷の治療指針
    鈍的大動脈損傷(BAI)の診断と治療指針
    脊髄損傷の評価と管理指針
    不安定型骨盤骨折の管理指針
    多発外傷患者における大腿骨骨幹部骨折に対する治療指針
    圧挫症候群の初期治療と予防の指針
    熱傷患者の管理指針
    電撃傷・雷撃傷の管理指針
    穿通性腹部外傷患者への予防的抗菌薬投与の指針
    外傷による病院前心肺停止の蘇生中止の指針
    高齢の外傷患者に対する指針
    外傷患者の静脈血栓塞栓症の予防指針
    外傷患者の栄養管理指針
    V.脳神経系疾患の診断・治療・ケア

    くも膜下出血の治療指針
    脳出血の治療指針
    a 脳梗塞の治療指針
    b 脳梗塞に対する血栓溶解療法の指針
    c 急性期脳梗塞に対する経カテーテル治療の指針
    d 一過性脳虚血発作(TIA)後の脳卒中予防のための指針
    痙攣の緊急診断と治療指針
    頭痛の緊急診断と治療指針
    脳卒中治療室(SCU)の退室指針 —再発予知のために—
    VI.呼吸器系疾患の診断・治療・ケア

    気道異物・窒息の緊急処置の指針
    気管切開の指針
    溺水の治療指針
    重症肺炎の治療指針
    小児気管支喘息の指針
    成人気管支喘息の指針
    妊婦の喘息発作の治療指
    慢性閉塞性肺疾患(COPD)の増悪の治療指針
    急性呼吸不全に対する非侵襲的陽圧換気(NPPV)の指針
    急性呼吸促迫症候群(ARDS)の人工呼吸管理指針
    急性呼吸促迫症候群(ARDS)の全身管理の指針
    輸血関連急性肺傷害(TRALI)の診断と治療指針
    自然気胸の治療指針
    人工呼吸器関連肺炎(VAP)の予防指針
    人工呼吸器からのウイニングの指針
    人工呼吸中の痛み・不穏・せん妄の管理指針
    人工呼吸中の栄養管理指針
    結核の診断と治療指針 —救急室・ICU での予防のために—
    嚥下障害による誤嚥防止の指針
    VII.心血管系疾患の診断・治療・ケア

    高血圧性緊急症の治療指針
    徐脈の緊急処置指針
    頻拍の緊急処置指針
    心房細動の緊急治療指針
    心臓手術後の心房細動の薬物療法の指針
    心房細動に対する緊急ペーシング指針
    心房細動に対する抗凝固療法の指針
    上室性不整脈の緊急治療指針
    急性冠症候群の治療指針
    ST上昇を伴う心筋梗塞の治療指針
    非ST上昇型急性冠症候群の治療指針
    急性心筋梗塞に対する血栓溶解療法の指針
    冠動脈疾患におけるカテーテルインターベンション(PCI)治療指針
    冠動脈バイパス術の指針
    周術期のCIED(ペースメーカ,ICD,CRT 等)の管理指針
    破裂性腹部大動脈瘤の治療指針
    感染性心内膜炎の予防と治療指針
    肺血栓塞栓症の予防と治療指針
    心不全の治療指針
    心疾患をもつ患者の非心臓手術時の周術期評価の指針
    VIII.消化器系疾患の診断・治療・ケア

    急性膵炎の診断と治療指針
    急性胆管炎,胆嚢炎の診療指針
    急性腹症の診断と治療指針
    消化管出血の診断と治療指針
    急性虫垂炎の診断と治療指針
    劇症肝炎の管理指針(Guidelines for fulminant hepatic failure)
    食道静脈瘤の治療指針
    胃食道逆流症(GERD)の診断と治療指針
    IX.代謝疾患の診断・治療・ケア

    糖尿病昏睡:糖尿病性ケトアシドーシス・高浸透圧高血糖状態・低血糖昏睡の治療指針
    甲状腺クリーゼ・粘液水腫の診断・治療の指針
    X.泌尿器・生殖器系疾患の診断・治療・ケア

    尿路結石の治療指針
    Acute kidney injury の診断・治療指針
    XI.産婦人科系疾患の診断・治療・ケア

    産科婦人科救急の初期評価と治療指針
    妊婦の心肺停止の管理指針
    XII.急性中毒の診断・治療・ケア

    メタノール中毒の治療指針
    エチレングリコール中毒の治療指針
    アセトアミノフェン中毒の治療指針
    その他の薬品中毒(三環系抗うつ薬,ジフェンヒドラミン,β-ブロッカー,カルシウムブロッカー)
    鉄誤飲による中毒治療の指針
    サリチル酸中毒の治療指針
    尿のアルカリ化の指標
    消化管除染の指針
    胃洗浄(急性中毒における)の指針
    腸洗浄(whole bowel irrigation)の指針
    下剤使用の指針
    活性炭による消化管除染の指針
    バイオテロ被災者の急性期ケアの指針
    XIII.環境障害・電解質異常・皮膚障害の診断・治療・ケア

    低体温症の管理指針
    熱中症の診断と治療指針
    致死的な電解質異常の治療指針
    中毒性表皮壊死症の診断と治療指針
    XIV.感染性疾患の診断・治療・ケア

    Clostridiodes(Clostridium)difficile感染症およびその対策
    メチシリン耐性黄色ブドウ球菌(MRSA)の診断と治療方針
    XV.精神障害・法医学・倫理の診断・治療・ケア

    PICSとその対策
    急性ストレス障害(ASD)・心的外傷後ストレス障害(PTSD)の指針
    集中治療室における終末期医療
    異状死の判定指針

  27. 今日の処方 改訂第6版

    松田直之( Role: Contributor ,  ショック)

    株式会社 南江堂  2019.3  ( ISBN:978-4-524-25119-3

     More details

    Total pages:904   Responsible for pages:8-15   Language:Japanese Book type:Textbook, survey, introduction

  28. 日本集中治療医学会専門医テキスト第3版 日本集中治療医学会教育委員会 編 Reviewed

    松田直之( Role: Contributor ,  心疾患の診断と管理)

    株式会社 シー・ビー・アール  2019.3  ( ISBN:978-4-908083-92-1

     More details

    Total pages:960   Responsible for pages:266-286   Language:Japanese Book type:Textbook, survey, introduction

  29. Histamine and sepsis. Histamine: Biology and Medical Aspects.

    Matsuda N,Hattori Y,Gando S.( Role: Joint author)

    Karger Spring Med Publishing Ltd.  2004.5 

     More details

    Language:English

  30. 急性期NPPVハンドブック

    松田直之( Role: Contributor ,  COPDでの高濃度酸素投与の問題点と対策について)

    株式会社 メディカル・ビュー  2017.10 

     More details

    Total pages:250   Responsible for pages:168-170   Language:Japanese Book type:Textbook, survey, introduction

  31. Pathological significance of over-production of histamine and altered transcriptional regulation of H1- and H2-receptors during septic shock.

    Matsuda N,Hattori Y,Kemmotsu O,Gando S.( Role: Joint author)

    Elsevier Science  2001.3 

     More details

    Language:English

▼display all

Presentations 11

  1. Educational lecture: "The cutting edge of perioperative sepsis managements" Invited

    Naoyuki Matsuda

    The 44th Annual Meeting of The Japan Society for Clinical Anesthesia  2024.11.22  The Japan Society for Clinical Anesthesia

     More details

    Event date: 2024.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:Tokyo   Country:Japan  

    [Introduction] The international definition of sepsis was changed to Sepsis-3 in 2016, and the "sepsis" changed from "systemic inflammation" in infectious diseases to "organ dysfunction". The pathophysiology of systemic inflammation is being elucidated in more detail based on 1) damage-associated molecular patterns (DAMPs) from surgery, trauma, burns, acute pancreatitis, etc., 2) immunodeficiency and DAMPs and pathogen-associated molecular patterns (PAMPs) associated with immune-linked diseases, and 3) PAMPs associated with perioperative infections. This educational lecture aims to summarize infection control and perioperative ecological invasion control as a clinical practice of anesthesiology, based on the molecular interpretation of DAMPs/PAMPs.
    [Content] This is an opportunity to consider systemic management, including perioperative infection control, based on the following nine contents from both clinical and basic perspectives. 1. Sepsis as a second attack on the body, 2. 1. Emergency emergency anesthesia for sepsis, 2. How to reverse septic shock, 3. Categorization of target bacteria, 5. Effective use of perioperative antibiotics and points to note, 6. Anesthesia for emergency surgery with flesh-eating bacteria, 7. Characteristics of bacteria that cannot be disinfected with alcohol, 8. Intensive care management for septic shock, 9. Management of neuromuscular junction in sepsis.

    [Conclusion] The perspective of "bioinvasive control," a theme in anesthesiology, is one of the essences of sepsis treatment. This is an opportunity to thoroughly implement infection control in the management of DAMPs as a bioinvasive treatment for scheduled surgery, and to consider the appropriateness of anesthesia for patients with sepsis in emergency surgery, as well as postoperative intensive care.

  2. Panel discussion: "Measures to deal with emergency demand" Invited

    Naoyuki Matsuda

    2024.11.21 

     More details

    Event date: 2024.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Akita   Country:Japan  

  3. Fluid management in patients with sepsis and septic shock Invited

    Naoyuki Matsuda MD, PhD

    KSCTVA/JACVA Joint Session  2024.9.22  Japanese society of Cardiovascular Anersthesiolosists

     More details

    Event date: 2024.9

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Horoshima   Country:Japan  

  4. Mitochondrial dysfunction in intensive care International conference

    Naoyuki Matsuda MD, PhD

    The 13th Critical Care Conference in Thailand  2024.7.12 

     More details

    Event date: 2024.7

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:Thai Society of Critical Care Medicine   Country:Thailand  

  5. Early Warning System : Emergency & Critical Care Medicine Invited International conference

    Naoyuki Matsuda MD, PhD

    Indonesia Network Symposium  2024.4.24  Muhammadiyah University of Makassar

     More details

    Event date: 2024.4

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:Makassar   Country:Indonesia  

  6. 画像から読み解く重症度と離床可否の判断「重症間質性肺炎の診断と治療」 Invited

    松田直之

    日本離床学会 教育セミナー  2025.2.15  日本離床学会

     More details

    Event date: 2025.2

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:WEB開催   Country:Japan  

  7. Pathophysiology of Sepsic Shock Invited International coauthorship

    Naoyuki Matsuda

    2024.12.14 

     More details

    Event date: 2024.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:Omiya   Country:Japan  

  8. 心臓血管手術における炎症管理

    松田直之

    日本心臓血管麻酔学会第30回学術大会  2024.9.21  日本心臓血管麻酔学会

     More details

    Event date: 2024.9

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Venue:広島   Country:Japan  

  9. Treatment of Septic Based on Japanese Lifestyle Background

    Naoyuki Matsuda MD, PhD

    The 13th Critical Care Conference in Thailand  2024.7.11  Thai Society of Ceritical Care Medicine

     More details

    Event date: 2024.7

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Bangkok   Country:Thailand  

  10. Pathophysiological Progression in Septic Shock Managements Invited

    Naoyuki Matsuda MD, PhD

    2024.4.12  Japan Shock Society

     More details

    Event date: 2024.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:Tokyo   Country:Japan  

  11. Immune Function in Critical Ill Patients

    Naoyuki Matsuda MD, PhD

    2024.3.15  Japanese Society of Intensive Care Medicine

     More details

    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:Sapporo   Country:Japan  

▼display all

Other research activities 10

  1. 世界敗血症デー9月13日〜敗血症の認知を高める活動〜. 週刊 日本医事新報 5237:60-61, 2024.

    2024.8

     More details

    世界敗血症デー9月13日〜敗血症の認知を高める活動〜. 週刊 日本医事新報 5237:60-61, 2024.

  2. 集中治療タスク・シフト/シェアに関する安全管理指針作成ワーキンググループ. 日本集中治療医学会 集中治療に係るタスク・シフト/シェアに関する安全管理指針. 日集中医誌 31:21-32, 2024.

    2024.4

     More details

    集中治療タスク・シフト/シェアに関する安全管理指針作成ワーキンググループ. 日本集中治療医学会 集中治療に係るタスク・シフト/シェアに関する安全管理指針. 日集中医誌 31:21-32, 2024.

  3. Mechanisms and systems of surgical intensive care.

    2024.12

     More details

    In Japan, surgical intensive care units (SICU) have developed since the late 1980s, primarily for cases in which postoperative recovery in a general ward is difficult, such as after cardiovascular surgery, esophageal surgery, pancreaticoduodenectomy, and radical hysterectomy. The need for SICUs can be broadly categorized into three major management considerations: (1) cases where surgical trauma is significant, (2) cases where preoperative comorbidities are severe, and (3) cases where intraoperative or postoperative complications arise.

    Most surgeries are performed as "elective surgeries," and preoperative management strategies such as smoking cessation, nutritional management, inflammation control (fever pattern, CRP levels), and blood glucose management (HbA1c levels) are implemented to optimize intraoperative and postoperative care. If sudden symptoms such as fever, inflammation, or an unstable increase in CRP are observed, surgery is postponed. Additionally, if HbA1c is high (normal <6.5%), surgery is delayed until blood glucose management stabilizes, with glycated hemoglobin (normal <17%) being used for monitoring. To optimize postoperative recovery, preoperative preparation is crucial, including (1) inflammation management (reducing the effects of intraoperative and postoperative inflammatory responses), (2) diabetes management (minimizing postoperative glucose intolerance), (3) smoking cessation management (reducing intraoperative and postoperative airway inflammation and suppressing excessive sputum production), (4) respiratory function assessment, (5) cardiac function assessment, (6) liver function assessment, and (7) renal function assessment. These factors collectively shape the intraoperative management plan, including anesthesia methods and anesthetic management.

    On the other hand, in cases requiring emergency surgery due to urgent hospital admission, the preoperative condition of the patient varies significantly compared to elective surgeries. Since preoperative preparation may be incomplete, SICUs play a vital role in reassessing the patient's overall condition and providing additional treatment. In addition to physicians, a multidisciplinary team is involved in patient care, including specialized nurses, clinical engineers (for appropriate management of medical devices), physical therapists (for early rehabilitation), pharmacists (for proper management of oral and intravenous medications), dietitians, and administrative assistants.

  4. 講座 救急・集中治療とサイトカイン「Interleukin-6」. 救急・集中治療 36:573-579, 2024.

    2024.10

     More details

    松田直之. 救急・集中治療とサイトカイン「Interleukin-6」. 救急・集中治療 36:573-579, 2024.

  5. 総説 外科系集中治療におけるPADISの考え方―鎮痛・鎮静・せん妄の管理―. 救急・集中治療 36:188-200, 2024.

    2024.10

     More details

    総説 外科系集中治療におけるPADISの考え方―鎮痛・鎮静・せん妄の管理―. 救急・集中治療 36:188-200, 2024.

  6. 講座 救急・集中治療とサイトカイン「Tumor Necrosis Factor」. 救急・集中治療 36:384-389, 2024.

    2024.10

     More details

    救急・集中治療とサイトカイン「Tumor Necrosis Factor」. 救急・集中治療 36:384-389, 2024.

  7. 総説 集中治療における感染管理. 消化外科 47:1177-1184, 2024

    2024.8

     More details

    総説 集中治療における感染管理. 消化外科 47:1177-1184, 2024

  8. 講座 外科系集中治療の仕組みとシステム. 救急・集中治療 36:1-11, 2024.

    2024.5

     More details

    講座 外科系集中治療の仕組みとシステム. 救急・集中治療 36:1-11, 2024.

  9. Review: Acute Liver Failure

    2024.5

  10. Review: Molecular mechanisms of sepsis-induced multiple organ failure

    2024.3

▼display all

KAKENHI (Grants-in-Aid for Scientific Research) 16

  1. Role of potassium channels on septic cardiomyopathy

    Grant number:23K08464  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Coinvestigator(s) 

  2. Transcriptome analysis and drug discovery in sepsis

    Grant number:23K24432  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

      More details

    Authorship:Principal investigator 

    Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )

  3. Sex differences based development of anti-sepsis drug

    Grant number:23K21461  2021.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

      More details

    Authorship:Coinvestigator(s) 

  4. Treatment strategy against sepsis induced thrombocytopenia and the associated complement hyperactivation

    Grant number:21K09065  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Coinvestigator(s) 

  5. Medical innovation using gene therapy of transcriptional factor STAT3 in septic multiple organ dysfunction

    Grant number:19H03757  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Naoyuki Matsuda

      More details

    Authorship:Principal investigator 

    Grant amount:\17290000 ( Direct Cost: \13300000 、 Indirect Cost:\3990000 )

    In septic mouse model (CLP) by cecal ligation and puncture, JAK2 activity and STAT3 activity was increased in time series. Synthetic administration of double-stranded STAT3 decoy oligodeoxynucleotide (ODN) reduced organ damage in major organs including the lungs, liver, kidneys. STAT3 decoy ODN reduced the overproduction of inflammatory cytokines and chemokines in CLP mice, and significantly suppressed the production of inflammatory molecules such as HMGB1 in the lungs and liver. The result clarifies the role of STAT3 in sepsis and suggests the potential usefulness of STAT3 decoy ODN in gene therapy for sepsis.

  6. Analysis of cardiac Ca2+ homeostasis in septic shock

    Grant number:17K11047  2017.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Watanabe Yasuhide

      More details

    Authorship:Coinvestigator(s) 

    We investigate cardiomyocyte Ca2+ kinetics and cardiac Na+/Ca2+ exchanger function in sepsis shock.Our collaborators reported dobutamine showed a positive inotropic effect on septic model mice (Sakai et al., 2017). We reported that carvedilol inhibited INCX in guinea-pig cardiac ventricular myocytes (Tashiro et al., 2017) and flecainide suppressed INCX (Kuroda et al., 2017). We reported that the effects of levosimendan and milrinone on hearts of septic mice (Yamashita et al., 2018) and our collaborators reported the elucidation on pathophysiologic mechanisms of septic shock and its application of new treatments (Suzuki et al., 2018). We reported that pinacidil enhanced INCX current in a NO-cGMP-PKG pathway (Iguchi et al., 2019) and summarized the mechanisms of cardioprotective drugs which enhanced NCX1 function (Watanabe, 2019).In 2020 and 2021,we researched in collaboration with the University of Shizuoka on cardiac contractility in septic shock.
    <BR>

  7. Drug discovery platform for improvement of positive inotropic effect in septic myocardium

    Grant number:15K15661  2015.4 - 2017.3

    Matsuda Naoyuki

      More details

    Authorship:Principal investigator 

    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

    We weighed the effects of dobutamine and milrinone as inotropes in BALB/c mice with cecal ligation and puncture (CLP)-induced sepsis. Surface expression levels of β1-adrenoceptors and alpha subunits of three main G protein families in myocardium were unaffected by CLP-induced sepsis. Plasma cyclic adenosine monophosphate (cAMP) levels were significantly elevated in both sham-operated and CLP mice in response to milrinone but only in sham-operated controls in response to dobutamine. Of phosphodiesterase (PDE) isoforms, PDE4D, but not PDE3A, both of which are responsible for cardiac cAMP hydrolysis, was significantly upregulated in CLP mouse myocardium. We define a novel mechanism for the impaired responsiveness to dobutamine as an inotrope in sepsis and understanding the role of PDE4D in modulating cardiac functional responsiveness in sepsis may open the potential of PDE4D-targeted therapeutic option in septic patients with low cardiac output who have a need for inotropic support.

  8. Gene therapy and application of iPS cells to major organ regeneration in septic multiple organ failure

    Grant number:25293365  2013.4 - 2017.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Matsuda Naoyuki

      More details

    Authorship:Principal investigator 

    Grant amount:\18460000 ( Direct Cost: \14200000 、 Indirect Cost:\4260000 )

    Sepsis causes fibroblast proliferation in various organs following systemic inflammation due to infection. For this process, we studied growth control of fibroblasts in mouse sepsis model and human fibroblast cell culture system. Male BALB-C mice of 8 to 12 weeks as a sepsis animal model were used to evaluate pathology by cecal ligation and puncture (CLP). Analysis of the distribution of fibroblasts using S100 calcium-binding protein, etc. showed an increase in fibroblasts in the lungs and the atrial fascia interface in the time course after CLP. In the study of cell culture of human fibroblast IMR-90, it was possible to evaluate that the β receptor activation by catecholamine and thrombin activity in systemic inflammation are strongly involved in fibroblast proliferation. It was revealed that fibroblast proliferation and organization was observed in association with inflammation of sepsis in the lung and heart.

  9. Analysis using knock-down methods for gene-associated receptor signaling in sepsis

    Grant number:23659843  2011.4 - 2013.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    MATSUDA Naoyuki

      More details

    Authorship:Principal investigator 

    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

    Sepsis is well known as a severe disease states corresponding emergency and intensive care. Sepsis is a systemic inflammatory reactions against viruses and bacteria, but effective therapy to control inflammation of the non-antibiotic still has not been established. In this study, to improve the survival rate of sepsis model mice by inhibiting gene transcription FADD, of TAK-1, such as by administering the siRNA, the manipulation reduced the LC3 expression level of lung, kidney, and aorta as gene recognition receptors. Subsequent analysis clarified the mechanism that inhibitions of both activation, autophagosome formation in sepsis pathology were not enhanced. The changeswere found as normalized functioning in electron microscope image. It can be said that it is considered by the suppression of gene-aware receptor signaling, leading to results that can reduce the organ inflammation associated bacterial infections, viral infections, in gene therapy, to have the significance of proposed new drug discovery in severe infection.

  10. Role of Autophagy and the Molecule Targeting in Sepsis

    Grant number:22249059  2010.4 - 2012.3

    MATSUDA Naoyuki

      More details

    Authorship:Principal investigator 

    Grant amount:\48750000 ( Direct Cost: \37500000 、 Indirect Cost:\11250000 )

    Sepsis, known as a inducer of severe multiple organ diseases, has no established effective treatment except for antibiotics. Sepsis can lead multiple organ failure due to amid acid transformation to acute phase proteins such as inflammatory cytokines. In this study, I have found that some parts of autophagy-related gene family wereincreased at transcriptional and translated levels in the acute terms of sepsis of cultured human vascular endothelial cells and sepsis mouse models. LC3 was activated in particular, and promoted an autophagosome formation. It was concluded that FADD, TAK-1 andtranscriptional activity of NF-κB and AP-1 were significantly related with autophagy acceleration in the cultured human vascular endothelial cells and sepsis mouse model.

  11. Bio-Marker of Severe Sepsis in Super-Senior Citizens

    Grant number:21指-22  2009.9 - 2010.3

      More details

    Authorship:Coinvestigator(s) 

  12. Detection of Circulating Endothelial Cells in Severe Sepsis

    Grant number:21390482  2009.4 - 2011.3

    KOIKE Kaoru

      More details

    Authorship:Coinvestigator(s) 

    Sepsis is a severe disorder as systemic inflammation with infection. In this illness, vascular endothelial damage proceeds to induce disseminated intravascular coagulation(DIC). This study revealed that circulating endothelial cell(CEC) was increased and plasma platelet count was decreased in the time dependent manner after sepsis induction by cecal ligation and puncture in male BALB-C mice. Nuclear factor-kappaB decoy oligonucleotides more strongly decreased CEC count than inactivation of FADD, TAK-1, and activator protein-1. The CEC count could be a reliable marker to evaluate DIC and dysfunction of vascular endothelium.

  13. Role of Bone Marrow Derived Stem Cells for Repair of Multiple Organs in Severe Sepsis

    Grant number:20659282  2008.4 - 2010.3

    Grant-in-Aid for Scientific Research 

      More details

    Authorship:Principal investigator 

  14. The transcription factor AP-1 as a molecular target in sepsis therapy

    Grant number:20590250  2008.4 - 2010.3

    Grants-in-Aid for Scientific Research 

    HATTORI Yuichi

      More details

    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    Polymicrobial sepsis was induced by cecal ligation and puncture (CLP) in BALB/c mice (8-12 wk of age). The DNA binding activity of AP-1, as assessed by electrophoretic mobility shift assay, was time-dependently increased in lung tissues from mice after the onset of CLP-induced sepsis. This increase was effectively eliminated by in vivo transfection of AP-1 decoy oligonucleotides (ODNs). Sepsis induction significantly increased surface expression of death receptors, such as TNF-R1, Fas, DR4, and DR5, in lung and aortic tissues after sepsis. Furthermore, the gene and protein levels of FADD, which recruits procaspase-8 into the death-inducing signaling complex, were increased after sepsis induction. These sepsis-induced changes were eliminated by systemic application of AP-1 decoy ODNs. TUNEL assays revealed that the significant appearance of cell apoptosis in lung and aortic tissue sections from septic mice was prevented by systemic treatment with AP-1 decoy ODNs. When endotoxic shock was induced by an intravenous injection of 10mg/kg lipopolysaccharide (LPS) in mice, expression levels of inflammatory molecules, including IL-1R, IL-6R, HMGB-1, and gp130, were highly increased, which was significantly inhibited by AP-1 decoy ODN treatment. All animals which received LPS died within 48h, and the animals that were treated with AP-1 decoy ODNs after LPS exhibited a striking improvement of survival. Our results suggest that AP-1 decoy ODN therapy represent an effective strategy in the treatment of sepsis. In addition, systemic administration of siRNA targeting FADD, which was found to be transactivated by AP-1, prevented the development of acute lung injury in CLP mice, and improved their survival. These findings indicate the potential usefulness of FADD siRNA for gene therapy of the septic syndrome.

  15. Gene Therapy of Severe Sepsis

    Grant number:19390405  2007.4 - 2010.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(B)

      More details

    Authorship:Principal investigator 

  16. Analysis of cerebral microcirculatory regulation in relation to anesthetics and gene therapy using the live-cell imaging

    Grant number:19390409  2007.4 - 2010.3

    Grants-in-Aid for Scientific Research 

    KINOSHITA Hiroyuki

      More details

    Authorship:Coinvestigator(s) 

    We employed the computer-assisted microscopy to evaluate microvascular function in the rat brain slices. Electrical stimulation induced constriction of the cerebral parenchymal arteriole, whereas an inhibitor of 20-HETE abolished this response. NMDA, which is one of excitatory amino acids, produced dilation of these arterioles, corresponding with intracellular production of superoxide in addition to nitric oxide in the smooth muscle cells. Propofol within clinically relevant concentrations reduced these vascular responses.

▼display all

 

Teaching Experience (On-campus) 39

  1. 名古屋大学 医学部大講堂講義 救急医学

    2024

     詳細を見る

    1 総論 救急・集中治療医学
    2 多臓器不全の病態と管理
    3.多発外傷の診断と治療
    7. 急性薬物中毒の診断と治療
    8 救急初期診療ER:診断と治療(1)
    9 救急初期診療ER:診断と治療(2)

  2. 名古屋大学全学講義 防災減災学「救急医療体制と減災医学」

    2024

     詳細を見る

    災害医療の初動体制と災害時医療における未然の予防策の講義

  3. 全学教養 現代医学入門「救急医療の仕組みと進歩」

    2024

     詳細を見る

    救急医学に関する基本事項,救急医療システムについての総論的講義

  4. 名古屋大学 医学部選択講義 多臓器不全の診断と治療

    2024

  5. 名大保健学科 講堂講義 救急医療と災害医療

    2024

  6. 名古屋大学 医学部大講堂講義 救急医学

    2023

     詳細を見る


    1 総論 救急・集中治療医学
    2 多臓器不全の病態と管理
    3 心肺蘇生の管理とエビデンス
    4 多発外傷の診断と治療
    5 広範囲熱傷の管理と治療
    6 急性薬物中毒の診断と治療
    7 災害医療・減災医療システム
    8 救急初期診療ER:診断と治療(1)
    9 救急初期診療ER:診断と治療(2)

  7. 名大保健学科 講堂講義 救急医療と災害医療

    2023

  8. 名古屋大学全学講義 防災減災学「救急医療体制と減災医学」

    2023

  9. 名古屋大学 医学部選択講義 多臓器不全の診断と治療

    2023

     詳細を見る


    1.総論:多臓器不全の病態と創薬視点
    2.ARDSの病態と治療
    3.ショックの病態と治療
    4.急性腎障害の病態と治療
    5.急性期の消化管と栄養の管理

  10. 名古屋大学 医学部大講堂講義 救急医学

    2022

     詳細を見る


    1 総論 救急・集中治療医学
    2 多臓器不全の病態と管理
    3 心肺蘇生の管理とエビデンス
    4 多発外傷の診断と治療
    5 広範囲熱傷の管理と治療
    6 急性薬物中毒の診断と治療
    7 災害医療・減災医療システム
    8 救急初期診療ER:診断と治療(1)
    9 救急初期診療ER:診断と治療(2)

  11. 名大保健学科 講堂講義 救急医療と災害医療

    2022

  12. 名古屋大学全学講義 防災減災学「救急医療体制と減災医学」

    2022

  13. 選択科目 多臓器不全の病態と治療

    2022

     詳細を見る


    1.総論:多臓器不全の病態と創薬視点
    2.ARDSの病態と治療
    3.ショックの病態と治療
    4.急性腎障害の病態と治療
    5.急性期の消化管と栄養の管理

  14. Emergency Medicine

    2021

  15. 選択講義 多臓器不全の診断と治療

    2021

     詳細を見る


    1.総論:多臓器不全の病態と創薬視点
    2.ARDSの病態と治療
    3.ショックの病態と治療
    4.急性腎障害の病態と治療
    5.急性期の消化管と栄養の管理

  16. 名大保健学科 講堂講義 救急医療と災害医療

    2021

  17. 名古屋大学全学講義 防災減災学「救急医療体制と減災医学」

    2021

  18. Emergency Medicine

    2020

  19. 選択講義 多臓器不全の管理ポイント

    2020

     詳細を見る


    1.総論 多臓器不全の病態学
    2.急性肺傷害の診断と治療
    3.ショックの診断と治療
    4.急性消化器症候群の病態と治療
    5.急性腎障害の診断と治療

  20. 名大保健学科 講堂講義 救急医療と災害医療

    2020

  21. 名古屋大学全学講義 防災減災学「救急医療体制と減災医学」

    2020

  22. 名古屋大学 医学部大講堂講義 救急医学

    2019

     詳細を見る

    大講堂講義内容
     本講では、総論として「救急医学」と「集中治療医学」の学術背景を解説し、各講義の中で救急患者の診断と治療、集中治療の診断と治療の考える根底を作ることを目的としています。講義数が9コマであり、救急医学と集中治療の学習の基盤を形成するための系統講義としています。

    臨床実習内容
     臨床実習では、救急科専門医および集中治療専門医により、実践的テーマを設定した講義と演習、そして患者さんを受け持つことによる実習が行われます。臨床実習は、医学部附属病院での診療に即した実習です。救急搬入の実際、急性期ベッドサイドでの診察などを通じて、急性期医療の診断と治療を学び、急性期管理医学の根底を整理して頂いています。院内外の実習を直接担当し、実習の最終日のまとめも担当させていただいています。また、臨床実習Ⅱでは、将来、救急医学に進みたいと考える希望者が、他病院での救急実習を含めて、より深く急性期医療を学ぶことができる内容とします。

  23. 名古屋大学全学講義 防災減災学「救急医療体制と減災医学」

    2019

     詳細を見る

    大規模災害時の医療システム構築についての講義

  24. 名大保健学科 大講堂講義 救急医療と災害医療

    2019

  25. 選択講義 多臓器不全の管理ポイント

    2019

  26. ALI/ARDSの病態と治療

    2010

     詳細を見る

    2010年より毎年継続

  27. Diagnosis and treatment of multiple organ failure

    2024

     詳細を見る

    This special lecture is aimed at medical students and will cover the following 5 themes, with a detailed discussion of the following as related to systemic management of major organs.

    (1) General overview of multiple organ failure: multiple organ failure and the ligand-receptor response, inflammatory molecules, autonomic nerve balances, immunity, infection, nutritional deficiency, and cell death.
    (2) Acute lung injury: the definition, pathology, diagnosis, and treatment of ARDS.
    (3) Shock: the definition, pathology, diagnosis, and treatment of shock.
    (4) Acute kidney injury: renal physiology, and the pathology and treatment of acute kidney injury.
    (5) Gastrointestinal injury and nutritional management: the acute pathology of the gastrointestinal tract and the liver, biliary and pancreas in comparison with normal conditions.

    We will discuss the above themes and have the academic foundation for systemic management of major organs with severe inflammation.

  28. ショックの病態と治療

    2010

     詳細を見る

    ショックの病態と治療

  29. 急性腎不全の管理

    2010

     詳細を見る

    2010年より毎年継続

  30. 急性期抗菌薬の適正使用

    2010

     詳細を見る

    2010年より毎年継続

  31. 急性期栄養管理の学術とポイント

    2010

     詳細を見る

    2010年より毎年継続

  32. 敗血症の病態生理学的研究と創薬

    2010

     詳細を見る

    2010年より毎年継続

  33. 人工呼吸器のモニタリング

    2010

     詳細を見る

    2010年より臨床実習中の講義および医師教育として通年の施行としている。年50回程度。

  34. 教養科目 生命科学と現代医療

    2021

     詳細を見る

    救急医療と集中治療に関する全学教養としての解説講義

  35. 特別講義 急性期多臓器不全の全身管理と研究

    2021

     詳細を見る

    集中治療医学に関する特別講義

    講義内容

    (1)総論:多臓器不全の病態学   救急・集中治療医学分野 教授 松田直之

     多臓器不全が進行する過程として,臓器を構成する上皮系細胞や血管内皮細胞の炎症を感知する細胞内情報伝達を考察する。脳,脊椎,筋骨格系,肺,心臓,血管,肝臓,腎臓,末梢神経,血液細胞の相互連関を解説する。今後の創薬研究の方向性について,広く討議する。
    Key word: damage-associated molecular patterns(DAMPs),pathogen-associated molecular patterns(PAMPs),Toll-like受容体,nucleotide-binding oligomerization domain(NOD), NOD-like receptors (NLRs),AIM2-like receptors(ALRs),retinoic acid-inducible gene-Ⅰ(RIG-Ⅰ)like receptors(RLRs),C型レクチン受容体,交感神経緊張,細胞内Ca2+過負荷,ミトコンドリア死,など

    (2)急性肺傷害の診断と治療    救急・集中治療医学分野 教授 松田直之

     急性肺傷害は,医師になれば必ず誰もが自身の担当している患者さんで遭遇する病態である。急性肺傷害に対しては,その原因となるDAMPsシグナルの主因の評価が大切であり,この緩和が治療の鍵となる。現在の急性肺傷害の定義,そして急性肺傷害の病態と治療を解説し,呼吸機能回復のための今後の研究を含めた討議とする。
    Key word: ARDS,ARDS Berlin定義,PaO2/FIO2,転写因子,Deathシグナル,Ⅱ型肺胞上皮細胞,骨髄由来多能性分化細胞,繊維芽細胞の細胞内情報伝達シグナル,血管透過性亢進,少量ステロイド療法,人工呼吸器の適正使用,PEEP,high flow nasal cannula,NPPVなど。

    (3)ショックの診断と治療      救急・集中治療医学分野 教授 松田直之

     ショックは急性循環不全と同義である。このショックの定義,ショックを呈する4つ病態,さらにショックがもたらす虚血と細胞死について解説し,各ショック分類に適した治療,播種性血管内凝固症候群を合併した際の病態と管理の方向性について解説する。
    Key word: 血流分布異常性ショック,循環血液量減少性ショック,心原性ショック,拘束性ショック,early goal-directed therapy,warm shock,cold shock, 細胞内Ca2+過負荷,網状皮斑(livedo),播種性血管内凝固症候群(DIC),など。

    (4)急性腎傷害の診断と治療   救急・集中治療医学分野 教授 松田直之

     腎臓の解剖学と生理学を復習し,その上で急性腎傷害の定義,急性腎傷害の病態学的解釈と治療を解説する。その上で,血液浄化法を用いる場合についての指針,透析療法と濾過療法の区分,吸着療法の3つのエッセンスをまとめる。腎機能回復のための今後の研究を含めた討議とする。
    Key word: KIDGOガイドライン,RIFLE criteria,AKIN criteria,クレアチニン,BUN,クレアチニン-クリアランス,ネフロン,たこ足細胞,メサンギウム細胞,持続血液濾過透析,CRRT,限外濾過,吸着,クリアランス,など。

    (5)急性期における消化管および栄養の管理  救急・集中治療医学分野 教授 松田直之
     消化管および肝胆膵の解剖と生理学および消化管ホルモンの作用を復習し,他の臓器傷害との関連性を論じる。また,急性期の栄養管理について,今後の研究を含めた討議とする。
    Key word: 消化管出血,輪状筋,縦走筋,消化管免疫,消化管内のpH管理,カルシウム感受性,急性肝不全,伊東細胞,急性膵炎ガイドライン,TOKYOガイドライン,急性期栄養管理,など。

  36. 救急医学

    2021

     詳細を見る

    講義内容

    (1)総論 救急・集中治療医学    救急・集中治療医学分野  教授 松田直之 
       救急医学と集中治療医学の対象とする緊急性と重症性の高い病態について、病態生理学的観点から診断と治療の概念を総括します。この講義の聴講により、救急医学のテキストを読みやすいものとします。本講では、さらに急性期管理医学としての管理システム構築方法や救急医療法制を解説し、救急医療を国における方向性と立ち位置、今後の形体や方策を論じます。重症感染症、多発外傷、広範囲熱傷、気道熱傷、肺挫傷、心肺停止などの実例を紹介し、救急医学と集中治療医学の概要を解説します。
      理解すべき内容とキイ・ワード:救急科専門医制度、救急医療システム、内因性疾患の急性増悪、交通外傷、広範囲熱傷、ヘリ搬送、ショック、救命、心肺停止、全身性炎症反応、交感神経症候群、サイトカインストーム、緊急性、重症度。

    (2)多臓器不全の病態と管理     救急・集中治療医学分野  教授 松田直之
       救急医学は、critical careおよびintensive careとして急性期病態を救命救急センターや集中治療室で管理する。この病態は、多臓器不全であり、生体侵襲に対して急性期の生体反応として生じる統一性が認められる。このような急性相反応、自律神経活性、全身性炎症と多臓器不全の関連について解説する。
      理解すべき内容とキイ・ワード:多臓器不全症候群、敗血症、全身性炎症案脳症候群、ARDS、肺線維症、ショック、AKI、急性脊髄傷害、急性消化管症候群、オートファジー、アポトーシス、炎症性サイトカイン、カテコラミン受容体シグナル、急性期再生医療。

    (3)心肺蘇生の管理エッセンス      救急・集中治療医学分野  教授 松田直之
       心肺停止の評価方法、2015年に改定された心肺蘇生ガイドラインに準じた心肺蘇生法、2015年までの心肺蘇生法などを解説します。既に実習では、basic life support(BLS)を習得していると思います。現在の心肺蘇生管理の仕組みを解説すします。この内容の理論的解釈に加えて、advanced life support(ACLS)の要点を整理し、心肺蘇生の重要内容を説明できることを目標とします。
      理解すべき内容とキイ・ワード:来院時心肺停止、CPAPA、気道確保、心臓マッサージ、BLS、ACLS、AED、交感神経症候群、接触感染予防、ARDS、AKI、蘇生後低酸素性脳症、低体温療法、脳蘇生。

    (4)多発外傷の診断と治療    救急・集中治療医学分野  教授 松田直之
       外傷診療は、救急医学における重要な診療内容の一つです。特に、全身管理を必要とする多発外傷の特徴、外傷患者の初期診療における標準化された診療内容、および「システム化」と「仕組み化」における知識を整理します。講義は、実際の多発外傷の症例提示を含めて、視覚的に、かつ管理における最先端内容を提示し、教科書を読みやすいものとします。
      理解すべき内容とキイ・ワード:JATEC、JPTEC、PAD、ABCDEアプローチ、ダブルアイ、primary survey、secondary survey、tertiary survey、病院前救護体制、AMPLE、FAST、PATBED2X、FIXES。

    (5)熱傷の管理と治療          救急・集中治療医学分野  教授 松田直之   熱傷の定義、深度分類、熱傷範囲の診断、重症度評価としてburn indexの求め方、輸液法、創処置と治療、再生医療の導入について解説します。その上で、広範囲熱傷における炎症管理としての集中治療について解説します。
      理解すべき内容とキイ・ワード:深達度、Ⅰ度熱傷、Ⅱ度熱傷、Ⅲ度熱傷、burn index、気道熱傷、シアン中毒、一酸化炭素中毒、皮膚移植。

    (6)急性薬物中毒の診断と治療    救急・集中治療医学分野  教授 松田直之
       急性薬物中毒は、救急疾患として頻回に認められる病態です。呼吸、循環、代謝を含めた適切な初期診療が必要となります。急性薬物中毒の一般的な診断と治療について解説し、薬理作用の復習とする一方で、全身管理の基本を整理します。特に臨床に用いられる薬物の中毒物質の種類、胃洗浄の具体的な方法、応急処置、および治療について解説します。
      理解すべき内容とキイ・ワード:気道確保、管制支障、胃洗浄、活性炭、血液浄化法、誤嚥性肺炎。

    (7)災害医療・減災医療システム   救急・集中治療医学分野  教授 松田直之
       南海地震、東南海連動地震が迫っていると言われていますが、このような震災が起きた際に、病院でどのような初動が行われるかを解説します。その一方で、バイオテロ、核対策も不可欠な時代となっています。阪神淡路大震災、東日本大震災、大規模犯罪、テロなどの実例を提示しながら、現在の災害医療システムについて概説し、救急医療、集中治療、ヘリコプターによる広域搬送システム、在宅医療との密接な関連として、救急医療の平素からの活動性の重要性を学術として解説します。講義内容としては、トリアージ方法、広域搬送の方法について、さらに疾病としては多発外傷、Crush症候群、一酸化炭素中毒、熱傷、溺水などとの関連について解説します。
      理解すべき内容とキイ・ワード:自然災害、人為的災害、救急医療、DMAT、JMAT、CSCATTT、METHANE、多発外傷診療、PTD、STARTトリアージ、PATトリアージ、広域搬送。

    (8)救急初期診療ER:診断と治療(1)  救急・集中治療医学分野  教授 松田直之
    (9)救急初期診療ER:診断と治療(2)  救急・集中治療医学分野  教授 松田直之
       救急外来を徒歩で来院する患者さんの主訴に対して、緊急性の高い鑑別診断として考えなければならない内容について、鑑別診断のアセスメントと治療を解説します。この代表的な主訴として、意識障害、発熱、胸痛、腹痛について、バイタルサインの時系列での評価方法を提示し、詳細な評価方法を解説します。一方、ER(Emergency Room)では、迅速診断に加えて、緊急性を形成する病態解釈と治療が不可欠です。臨床実習に先立った基礎形成期として、急性肺傷害、ショック、急性腎傷害、重症感染症、環境異常症について解説します。
      理解すべき内容とキイ・ワード:鑑別診断、緊急性、重症性,アセスメント、治療指針。

  37. 現代医療と生命科学

    2021

     詳細を見る

    救急医療と集中治療についての講義

  38. 現代医療と生命科学

    2019

     詳細を見る

    全学教養授業として,90分2コマ,180分の講義を担当した。

  39. Life Sciences and Modern Medicine

    2011

▼display all

Teaching Experience (Off-campus) 19

  1. Universitas Muhammadiyah Emergency Medicine

    2024.4

     More details

    Level:Undergraduate (liberal arts)  Country:Indonesia

  2. 京都大学医学部医学科 救急医学(大講堂講義・臨床実習)

    2007.4 - 2010.3 Kyoto University)

     More details

    Level:Undergraduate (specialized) 

  3. 京都大学医学部保健学科 リハビリテーション 大講堂講義

    2007.4 - 2010.3 Kyoto University)

     More details

    Level:Undergraduate (specialized)  Country:Japan

  4. 富山大学医学部医学科 麻酔科学 大講堂講義

    2006.4 - 2020.3 University of Toyama)

     More details

    Level:Undergraduate (specialized)  Country:Japan

  5. 富山大学医学部医学科 薬理学 大講堂講義

    2006.4 - 2019.3 University of Toyama)

     More details

    Level:Undergraduate (specialized)  Country:Japan

  6. 北海道大学医学部医学科 救急医学(大講堂講義・臨床実習)

    2000.4 - 2006.3 Hokkaido University)

     More details

    Level:Undergraduate (specialized)  Country:Japan

  7. 北海道大学医学部医学科 大講堂講義 薬理学

    1997.4 - 2005.3 Hokkaido University)

     More details

    Level:Undergraduate (specialized)  Country:Japan

  8. Emergency Treatment

    2024.4

     More details

    Level:Other 

  9. Emnergency Medicine

    2021.4 Aichi Mizuho College)

     More details

    Level:Undergraduate (specialized)  Country:Japan

  10. 東北大学 麻酔・蘇生学  大講堂講義 敗血症/SIRS研究の基礎と臨床

    2009.4 - 2013.3 東北大学医学部)

     More details

    Country:Japan

  11. 京都府立医科大学 救急医学 大講堂講義 急性薬物中毒の診断と治療

    2009.4 - 2010.3 京都府立医科大学)

     More details

    Level:Undergraduate (specialized)  Country:Japan

  12. 京都府立医科大学 臨床薬理学「救急医療と薬理学」

    2009.4 - 2010.3 京都府立医科大学)

     More details

    Level:Undergraduate (specialized) 

  13. 徳島大学 救急医学 大講堂講義 循環管理・ショック

    2009.4 - 2013.3 徳島大学医学部)

     More details

    Level:Undergraduate (specialized) 

  14. Infection Management in Emergency Medicine

    2011.4

  15. 富山大学 呼吸器内科「急性肺障害の診断と治療」

    2009.4 - 2010.3 富山大学医学部)

  16. 富山大学 臨床薬理学「救急・集中治療におけるEBMの実践」

    2009.4 - 2018.3 富山大学医学部)

     More details

    Level:Undergraduate (specialized)  Country:Japan

  17. 星薬科大学 早期体験学習 救急・集中治療

    2009.4 - 2010.3 Hoshi University)

  18. 静岡県立大学 大学院特別講義

    2019.4 - 2020.3 University of Shizuoka)

     More details

    Level:Postgraduate  Country:Japan

  19. 富山大学 大学院特別講義

    2006.4 - 2020.3 University of Toyama)

     More details

    Level:Graduate (liberal arts) 

▼display all

 

Social Contribution 7

  1. World sepsis Day Kyoto 2024

    Role(s):Appearance, Panelist, Commentator, Presenter, Media coverage, Lecturer, Planner, Organizing member, Demonstrator, Contribution

    Naoyuki Matsuda MD, PhD  Kyoto Station  2024.9

     More details

    Audience: Junior students, High school students, College students, Graduate students, Teachers, Researchesrs, General, Scientific, Company, Civic organization, Governmental agency, Media

    Type:Science festival

    In order to raise awareness of sepsis, "World Sepsis Day" was held on September 8, 2024 at Muromachi-koji Square on the 4th floor of Kyoto Station. The total number of participants was about 10,000, of which about 350 were seated in the stepped seating on the floor, making it a large-scale sepsis awareness activity on a global world scale. I was the producer and director of this event.

  2. Sepsis Festival 2019 in NAGOYA

    Role(s):Panelist, Commentator, Presenter, Media coverage, Interviewer, Editer, Lecturer, Informant, Planner, Organizing member, Demonstrator, Contribution

    Naoyuki Matsuda MD, PhD  2019.3 - 2019.4

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students, College students, Graduate students, Teachers, Guardians, Researchesrs, General, Scientific, Company, Civic organization, Governmental agency, Media

    Type:Science festival

  3. Medical support for patients with severe burns after a dust explosion in Taiwan

    Role(s):Panelist, Lecturer, Advisor, Informant, Organizing member, Investigater, Report writing, Contribution

    Japan Medical Association  Taiwan  2015.7 - 2015.11

     More details

    Audience: High school students, College students, Graduate students, Teachers, Guardians, Researchesrs, General, Scientific, Company, Civic organization, Governmental agency, Media

    Type:Investigation, survey

    On June 27th of this year, a dust explosion occurred at a theme park in Taiwan, leaving approximately 500 young people with severe burns. A team of specialist doctors from Japan worked hard to provide treatment using artificial skin and medical supplies donated from Japan.

    In response to a request for emergency medical support from the Taiwan Medical Association and other organizations, the Japan Medical Association dispatched six burn treatment specialists from the Japanese Society of Intensive Care Medicine, the Japanese Society of Emergency Medicine, and the Japanese Burn Association as the Japan Medical Association's "Tri-Society Joint Burn Medical Support Team" from July 12th to 15th. As the leader of this team, he handled medical cooperation, information sharing, health meetings, and interviews.

    The Japan Medical Association held a press conference to announce the following:

    July 15: Emergency medical support for victims of severe burns caused by an explosion accident in Taiwan based on the iJN-France-T initiative

    August 5: Attending the iJN-France-T Agreement Signing Ceremony with the Taiwan Medical Association

    September 9: Report on the activities of the "Hakuhon Medical Association Three-School Joint Burn Treatment Support Team" in the Taiwan Dust Explosion Accident

    October 28: Funding for medical support activities for patients with severe burns caused by an explosion accident in Taiwan

  4. World Sepsis Day in Nagoya and Tokai, Japan

    Role(s):Appearance, Panelist, Commentator, Presenter, Media coverage, Lecturer, Advisor, Informant, Organizing member, Demonstrator, Contribution

    Naoyuki Matsuda project  Interviews, Article postings, CBC Radio, etc.  2012.9

     More details

    Audience: Schoolchildren, Junior students, High school students, College students, Graduate students, Teachers, Guardians, Researchesrs, General, Scientific, Company, Civic organization, Media

    Type:TV or radio program

  5. World Sepsis Day/ Global Sepsis Alliance

    Role(s):Appearance, Commentator, Lecturer, Contribution

    2010.2

  6. 刑事事件捜査/証人召喚 令和4年(わ)第1850号 

    Role(s):Advisor, Informant, Investigater

    名古屋地方裁判所  2024.1 - 2025.1

     More details

    Audience: General, Governmental agency

    Type:Investigation, survey

    司法協力:傷害致死における死亡事由の病態生理学的解釈の提供および解説
    第2号法廷(1F)2024年2月14日
    第601号法廷(6F)2025年1月29日

  7. Global Sepsis Alliance 世界敗血症デー in NAGOYA

    Role(s):Panelist, Commentator, Presenter, Chief editor, Interviewer, Editer, Lecturer, Advisor, Informant, Planner, Organizing member, Demonstrator, Investigater, Report writing

    2011.9

     More details

    Type:Lecture

    敗血症の診療成績を高めるために,Global Sepsis Allianceに所属し,東海地方にGlobal Sepsis Alliance in NAGOYAを設立しました。年1回9月13日を世界敗血症デイとし,世界と連携して東海および日本の敗血症診療キャンペーンを実施しています。「Global Sepsis Alliance in NAGOYA」の代表として,感染症診療の適正化に向けた国際連携を展開しています。

▼display all

Media Coverage 3

  1. 世界と連携した集中治療教育 TV or radio program

    松田直之  2007.1

     More details

    集中治療の教育活動を,講演,メディア,誌上掲載などの方策として,世界と連携して行っています。

  2. 救急医療を知るための会 TV or radio program

    松田直之  2005.4

     More details

    救急医療のすべてについて,仕組み作り,重要な管理内容,救急医療の詳細等について,講演,実演,アドバイスなどを,日本救急医学会指導医・専門医として広く行っています。

  3. 敗血症という病態を知っていただくための会

    1998.4

     More details

    敗血症について,医療従事者のみではなく,広く市民の皆さまに情報提供しています。

Academic Activities 3

  1. World Sepsis Day Kyoto 2024 International contribution

    Role(s):Planning, management, etc., Panel moderator, session chair, etc., Supervision (editorial), Planning/Implementing academic research

    Naoyuki Matsuda  2024.9

     More details

    Type:Competition, symposium, etc. 

  2. 救急医療に関する報道協力 International contribution

    Role(s):Planning, management, etc., Panel moderator, session chair, etc., Supervision (editorial), Review, evaluation, Planning/Implementing academic research, Peer review

    テレビ局・ラジオ局  2000.4

     More details

    Type:Scientific advice/Review 

    救急医療のかかえる現在の課題,そして将来の展望について,さまざまなインタビューに協力し,本邦および世界の救急医療の発展に貢献する方針としています。

  3. Press cooperation on the management of various types of infectious diseases and sepsis

    Role(s):Planning, management, etc., Panel moderator, session chair, etc., Supervision (editorial), Review, evaluation, Planning/Implementing academic research, Peer review

    2010.2

     More details

    Type:Scientific advice/Review 

    Many understandings about the management of infectious diseases and sepsis will be provided to contribute Japan and the world.