北海道大学大学院医学研究科・救急医学分野・学内講師

2004.4 - 2006.1

北海道大学病院 救急部・集中治療部・助手

2000.10 - 2006.1

北海道大学医学部附属病院 救急部・集中治療部・医員

2000.4 - 2000.9

北海道砂川市立病院・医員

1994.4 - 1995.3

北海道大学医学部附属病院・研修医

1993.4 - 1994.3

日本集中治療医学会   集中治療薬剤委員会・委員長

2021.4

日本集中治療医学会   広報委員会・委員長

2014.4

日本集中治療医学会   Global Sepsis Alliance委員会・担当理事

2019.1

日本救急医学会中部地方会   理事

2011.4

日本臨床麻酔学会   理事

2010.4

日本感染症学会

日本化学療法学会

日本外傷学会

日本呼吸器学会

日本薬理学会   評議員

2005.4 - 2006.3

日本炎症・再生医学会

日本ペインクリニック学会

Japanese Society of Intensive Care Medicine   Chairman of International Committee

2013.4 - 2017.3

日本心臓血管麻酔学会   編集委員長

2011.4 - 2016.3

日本集中治療医学会   専門医委員会 委員

2010.4 - 2011.3

日本臨床麻酔学会   査読委員

2007.4

日本外科感染症学   医の質・安全委員会 副委員長

2007.4

日本循環制御医学会   機関誌編集委員

2007.4 - 2013.3

the Society of Critical Care Medicine   Internal Medicine Section member

2007.4 - 2008.3

日本外科感染症学会誌   編集委員・査読委員

2006.4 - 2012.3

日本心臓血管麻酔学会   文献レビュー委員会 委員長

2006.4 - 2010.3

日本集中治療医学会   評議員

2005.4

日本麻酔科学会   評議員

2005.4 - 2010.3

American Society of Anesthesiologist

2004年日本集中治療医学会 優秀論文賞

2005.2   日本集中治療医学会  

日本ヒスタミン研究会 第1回和田記念賞

2004.12   日本ヒスタミン研究会  

33th米国集中治療医学会 Annual Scientific Award

2004.2   米国集中治療医学会  

日本救急医学会 丸茂賞

2003.11   日本救急医学会  

北海道麻酔科学会 第15回高橋賞

2002.9   北海道麻酔科学会  

Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea-pig lungs using methylprednisolone. Reviewed

  Vol. 295   page： L998-L1006   2008.11

Roles of phosphatidylinositol 3-kinase and NADPH oxidase in ATP-sensitive K+ channel function impaired by high glucose in the human artery. Reviewed

Hypertension   Vol. 52   page： 507-513   2008.5

*Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock. Reviewed

Matsuda N,Takano Y,Kageyama S,Hatakeyama N,Shakunaga K,Kitajima I,Yamazaki M,Hattori Y.

Cardiovasc Res   Vol. 76   page： 132-140   2007.6

Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: reversal effect of fluvastatin therapy. Reviewed

Matsuda N,Hayashi Y, Takahashi Y,Hattori Y.

J Pharmacol Exp Ther   Vol. 319   page： 1348-1354   2006.10

Role of MIF in acute lung injury in mice with acute pancreatitis complicated by endotoxemia. Reviewed

Matsuda N,Nishihira J,Takahashi Y,Kennmotsu O,Hattori Y.

Am J Respir Cell Mol Biol   Vol. 35   page： 198-205   2006.7

*Nuclear Factor-kB decoy oligonucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis. Reviewed

Matsuda N,Hattori Y,Takahashi Y,Subrina Jesmin,Gando S.

Mol Pharmacol   Vol. 67   page： 1018-1025   2005.5

Therapeutic effect of in vivo transfection of transcription factor decoy to NF-kB on septic lung in mice.

Matsuda N,Hattori Y,Takahashi Y,Nishihira J,Jesmin S,Kobayashi M,Gando S.

Am J Physiol Lung Cell Mol Physiol   Vol. 287   page： L1248-L1255   2004.4

The modulation of vascular ATP-sensitive K+ channel function via phosphatidylinositol 3-kinase-Akt pathway activated by phenylephrine. Reviewed

Haba M, Hatakeyama N, Kinoshita H, Teramae H, Azma T, Hatano Y, Matsuda N.

J Pharmacol Exp Ther   Vol. 334   page： 673-678   2010.9

[Molecular mechanisms underlying the pathogenesis of septic multiple organ failure].

Matsuda N, Machida T, Hattori Y

Nihon yakurigaku zasshi. Folia pharmacologica Japonica   Vol. 159 ( 2 ) page： 101 - 106   2024

Administration of lipid emulsion reduced the hypnotic potency of propofol more than that of thiamylal in mice

Higashi, M; Taharabaru, S; Adachi, YU; Satomoto, M; Tamura, T; Matsuda, N; Sato-Boku, A; Okuda, M

EXPERIMENTAL ANIMALS   Vol. 72 ( 4 ) page： 468 - 474   2023

Survey on the current status of the indication and implementation protocols for bile replacement in patients with external biliary drainage with special reference to infection control

Shinkawa, H; Kubo, S; Mikamo, H; Matsuda, N; Omura, K; Okamoto, K; Ono, S; Obara, H; Kobayashi, M; Sasaki, J; Shimizu, J; Sueyoshi, S; Yoshida, J; Watanabe, M; Takesue, Y

SURGERY TODAY   Vol. 52 ( 10 ) page： 1446 - 1452   2022.10

Vascular endotheliitis associated with infections: Its pathogenetic role and therapeutic implication

Hattori, Y; Hattori, K; Machida, T; Matsuda, N

BIOCHEMICAL PHARMACOLOGY   Vol. 197   page： 114909   2022.3

[Vascular hyperpermeable molecules potentially contributing to the development of pulmonary edema in sepsis-associated ARDS].

Hattori K, Matsuda N, Hattori Y

Nihon yakurigaku zasshi. Folia pharmacologica Japonica   Vol. 157 ( 4 ) page： 226 - 231   2022

Clinical paper The rCAST score is useful for estimating the neurological prognosis in pediatric patients with post-cardiac arrest syndrome before ICU admission: External validation study using a nationwide prospective registry

Yasuda Yuma, Nishikimi Mitsuaki, Matsui Kota, Numaguchi Atsushi, Nishida Kazuki, Emoto Ryo, Matsui Shigeyuki, Matsuda Naoyuki

RESUSCITATION   Vol. 168   page： 103 - 109   2021.11

Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock

Hiraiwa Hiroaki, Kasugai Daisuke, Ozaki Masayuki, Goto Yukari, Jingushi Naruhiro, Higashi Michiko, Nishida Kazuki, Kondo Toru, Furusawa Kenji, Morimoto Ryota, Okumura Takahiro, Matsuda Naoyuki, Matsui Shigeyuki, Murohara Toyoaki

SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page： 18823   2021.9

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).

Egi M, Ogura H, Yatabe T, Atagi K, Inoue S, Iba T, Kakihana Y, Kawasaki T, Kushimoto S, Kuroda Y, Kotani J, Shime N, Taniguchi T, Tsuruta R, Doi K, Doi M, Nakada TA, Nakane M, Fujishima S, Hosokawa N, Masuda Y, Matsushima A, Matsuda N, Yamakawa K, Hara Y, Sakuraya M, Ohshimo S, Aoki Y, Inada M, Umemura Y, Kawai Y, Kondo Y, Saito H, Taito S, Takeda C, Terayama T, Tohira H, Hashimoto H, Hayashida K, Hifumi T, Hirose T, Fukuda T, Fujii T, Miura S, Yasuda H, Abe T, Andoh K, Iida Y, Ishihara T, Ide K, Ito K, Ito Y, Inata Y, Utsunomiya A, Unoki T, Endo K, Ouchi A, Ozaki M, Ono S, Katsura M, Kawaguchi A, Kawamura Y, Kudo D, Kubo K, Kurahashi K, Sakuramoto H, Shimoyama A, Suzuki T, Sekine S, Sekino M, Takahashi N, Takahashi S, Takahashi H, Tagami T, Tajima G, Tatsumi H, Tani M, Tsuchiya A, Tsutsumi Y, Naito T, Nagae M, Nagasawa I, Nakamura K, Nishimura T, Nunomiya S, Norisue Y, Hashimoto S, Hasegawa D, Hatakeyama J, Hara N, Higashibeppu N, Furushima N, Furusono H, Matsuishi Y, Matsuyama T, Minematsu Y, Miyashita R, Miyatake Y, Moriyasu M, Yamada T, Yamada H, Yamamoto R, Yoshida T, Yoshida Y, Yoshimura J, Yotsumoto R, Yonekura H, Wada T, Watanabe E, Aoki M, Asai H, Abe T, Igarashi Y, Iguchi N, Ishikawa M, Ishimaru G, Isokawa S, Itakura R, Imahase H, Imura H, Irinoda T, Uehara K, Ushio N, Umegaki T, Egawa Y, Enomoto Y, Ota K, Ohchi Y, Ohno T, Ohbe H, Oka K, Okada N, Okada Y, Okano H, Okamoto J, Okuda H, Ogura T, Onodera Y, Oyama Y, Kainuma M, Kako E, Kashiura M, Kato H, Kanaya A, Kaneko T, Kanehata K, Kano KI, Kawano H, Kikutani K, Kikuchi H, Kido T, Kimura S, Koami H, Kobashi D, Saiki I, Sakai M, Sakamoto A, Sato T, Shiga Y, Shimoto M, Shimoyama S, Shoko T, Sugawara Y, Sugita A, Suzuki S, Suzuki Y, Suhara T, Sonota K, Takauji S, Takashima K, Takahashi S, Takahashi Y, Takeshita J, Tanaka Y, Tampo A, Tsunoyama T, Tetsuhara K, Tokunaga K, Tomioka Y, Tomita K, Tominaga N, Toyosaki M, Toyoda Y, Naito H, Nagata I, Nagato T, Nakamura Y, Nakamori Y, Nahara I, Naraba H, Narita C, Nishioka N, Nishimura T, Nishiyama K, Nomura T, Haga T, Hagiwara Y, Hashimoto K, Hatachi T, Hamasaki T, Hayashi T, Hayashi M, Hayamizu A, Haraguchi G, Hirano Y, Fujii R, Fujita M, Fujimura N, Funakoshi H, Horiguchi M, Maki J, Masunaga N, Matsumura Y, Mayumi T, Minami K, Miyazaki Y, Miyamoto K, Murata T, Yanai M, Yano T, Yamada K, Yamada N, Yamamoto T, Yoshihiro S, Tanaka H, Nishida O

Journal of intensive care   Vol. 9 ( 1 ) page： 53   2021.8

Impact of a long-term high-glucose environment on pro-inflammatory responses in macrophages stimulated with lipopolysaccharide

Suzuki Tokiko, Yamashita Shigeyuki, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY     2021.8

Outcome Related to Level of Targeted Temperature Management in Postcardiac Arrest Syndrome of Low, Moderate, and High Severities: A Nationwide Multicenter Prospective Registry

Nishikimi Mitsuaki, Ogura Takayuki, Nishida Kazuki, Hayashida Kei, Emoto Ryo, Matsui Shigeyuki, Matsuda Naoyuki, Iwami Taku

CRITICAL CARE MEDICINE   Vol. 49 ( 8 ) page： E741 - E750   2021.8

Relative platelet reductions provide better pathophysiologic signatures of coagulopathies in sepsis

Kasugai Daisuke, Ozaki Masayuki, Nishida Kazuki, Goto Yukari, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page： 14033   2021.7

Failure of non-invasive respiratory support after 6 hours from initiation is associated with ICU mortality

Nishikimi Mitsuaki, Nishida Kazuki, Shindo Yuichiro, Shoaib Muhammad, Kasugai Daisuke, Yasuda Yuma, Higashi Michiko, Numaguchi Atsushi, Yamamoto Takanori, Matsui Shigeyuki, Matsuda Naoyuki

PLOS ONE   Vol. 16 ( 4 ) page： e0251030   2021.4

A case of reexpansion pulmonary edema and acute pulmonary thromboembolism associated with diffuse large B-cell lymphoma treated with venovenous extracorporeal membrane oxygenation.

Kazama S, Hiraiwa H, Kimura Y, Ozaki R, Shibata N, Arao Y, Oishi H, Kato H, Kuwayama T, Yamaguchi S, Kondo T, Furusawa K, Morimoto R, Okumura T, Bando YK, Sato T, Shimada K, Kiyoi H, Nakamura G, Yasuda Y, Kasugai D, Ogawa H, Higashi M, Yamamoto T, Jingushi N, Ozaki M, Numaguchi A, Goto Y, Matsuda N, Murohara T

Journal of cardiology cases   Vol. 23 ( 1 ) page： 53 - 56   2021.1

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).

Egi M, Ogura H, Yatabe T, Atagi K, Inoue S, Iba T, Kakihana Y, Kawasaki T, Kushimoto S, Kuroda Y, Kotani J, Shime N, Taniguchi T, Tsuruta R, Doi K, Doi M, Nakada TA, Nakane M, Fujishima S, Hosokawa N, Masuda Y, Matsushima A, Matsuda N, Yamakawa K, Hara Y, Sakuraya M, Ohshimo S, Aoki Y, Inada M, Umemura Y, Kawai Y, Kondo Y, Saito H, Taito S, Takeda C, Terayama T, Tohira H, Hashimoto H, Hayashida K, Hifumi T, Hirose T, Fukuda T, Fujii T, Miura S, Yasuda H, Abe T, Andoh K, Iida Y, Ishihara T, Ide K, Ito K, Ito Y, Inata Y, Utsunomiya A, Unoki T, Endo K, Ouchi A, Ozaki M, Ono S, Katsura M, Kawaguchi A, Kawamura Y, Kudo D, Kubo K, Kurahashi K, Sakuramoto H, Shimoyama A, Suzuki T, Sekine S, Sekino M, Takahashi N, Takahashi S, Takahashi H, Tagami T, Tajima G, Tatsumi H, Tani M, Tsuchiya A, Tsutsumi Y, Naito T, Nagae M, Nagasawa I, Nakamura K, Nishimura T, Nunomiya S, Norisue Y, Hashimoto S, Hasegawa D, Hatakeyama J, Hara N, Higashibeppu N, Furushima N, Furusono H, Matsuishi Y, Matsuyama T, Minematsu Y, Miyashita R, Miyatake Y, Moriyasu M, Yamada T, Yamada H, Yamamoto R, Yoshida T, Yoshida Y, Yoshimura J, Yotsumoto R, Yonekura H, Wada T, Watanabe E, Aoki M, Asai H, Abe T, Igarashi Y, Iguchi N, Ishikawa M, Ishimaru G, Isokawa S, Itakura R, Imahase H, Imura H, Irinoda T, Uehara K, Ushio N, Umegaki T, Egawa Y, Enomoto Y, Ota K, Ohchi Y, Ohno T, Ohbe H, Oka K, Okada N, Okada Y, Okano H, Okamoto J, Okuda H, Ogura T, Onodera Y, Oyama Y, Kainuma M, Kako E, Kashiura M, Kato H, Kanaya A, Kaneko T, Kanehata K, Kano KI, Kawano H, Kikutani K, Kikuchi H, Kido T, Kimura S, Koami H, Kobashi D, Saiki I, Sakai M, Sakamoto A, Sato T, Shiga Y, Shimoto M, Shimoyama S, Shoko T, Sugawara Y, Sugita A, Suzuki S, Suzuki Y, Suhara T, Sonota K, Takauji S, Takashima K, Takahashi S, Takahashi Y, Takeshita J, Tanaka Y, Tampo A, Tsunoyama T, Tetsuhara K, Tokunaga K, Tomioka Y, Tomita K, Tominaga N, Toyosaki M, Toyoda Y, Naito H, Nagata I, Nagato T, Nakamura Y, Nakamori Y, Nahara I, Naraba H, Narita C, Nishioka N, Nishimura T, Nishiyama K, Nomura T, Haga T, Hagiwara Y, Hashimoto K, Hatachi T, Hamasaki T, Hayashi T, Hayashi M, Hayamizu A, Haraguchi G, Hirano Y, Fujii R, Fujita M, Fujimura N, Funakoshi H, Horiguchi M, Maki J, Masunaga N, Matsumura Y, Mayumi T, Minami K, Miyazaki Y, Miyamoto K, Murata T, Yanai M, Yano T, Yamada K, Yamada N, Yamamoto T, Yoshihiro S, Tanaka H, Nishida O

Acute medicine & surgery   Vol. 8 ( 1 ) page： e659   2021.1

JM-1232(-) and propofol, a new combination of hypnotics with short-acting and non-cumulative preferable properties

Taharabaru, S; Tamura, T; Higashi, M; Matsuda, N; Satomoto, M; Adachi, YU; Sato, AB; Okuda, M

EXPERIMENTAL ANIMALS   Vol. 70 ( 1 ) page： 101 - 107   2021

Relative bradycardia as a clinical feature in patients with coronavirus disease 2019 (COVID-19): A report of two cases.

Hiraiwa H, Goto Y, Nakamura G, Yasuda Y, Sakai Y, Kasugai D, Jinno S, Tanaka T, Ogawa H, Higashi M, Yamamoto T, Jingushi N, Ozaki M, Numaguchi A, Kondo T, Morimoto R, Okumura T, Matsuda N, Murohara T

Journal of cardiology cases   Vol. 22 ( 6 ) page： 260 - 264   2020.12

Vascular endothelial growth factor contributes to lung vascular hyperpermeability in sepsis-associated acute lung injury

Tomita Kengo, Saito Yuna, Suzuki Tokiko, Imbaby Samar, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY   Vol. 393 ( 12 ) page： 2365 - 2374   2020.12

Impact of patient characteristics on the efficacy and safety of landiolol in patients with sepsis-related tachyarrhythmia: Subanalysis of the J-Land 3S randomised controlled study

Matsuda Naoyuki, Nishida Osamu, Taniguchi Takumi, Okajima Masaki, Morimatsu Hiroshi, Ogura Hiroshi, Yamada Yoshitsugu, Nagano Tetsuji, Ichikawa Akira, Kakihana Yasuyuki

ECLINICALMEDICINE   Vol. 28   page： 100571   2020.11

Beneficial effect of STAT3 decoy oligodeoxynucleotide transfection on organ injury and mortality in mice with cecal ligation and puncture-induced sepsis

Imbaby Samar, Matsuda Naoyuki, Tomita Kengo, Hattori Kohshi, Palikhe Sailesh, Yokoo Hiroki, Hattori Yuichi

SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page： 15316   2020.9

Efficacy and safety of landiolol, an ultra-short-acting beta 1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): a multicentre, open-label, randomised controlled trial

Kakihana Yasuyuki, Nishida Osamu, Taniguchi Takumi, Okajima Masaki, Morimatsu Hiroshi, Ogura Hiroshi, Yamada Yoshitsugu, Nagano Tetsuji, Morishima Eiichiro, Matsuda Naoyuki

LANCET RESPIRATORY MEDICINE   Vol. 8 ( 9 ) page： 863 - 872   2020.9

STAT3 decoy oligodeoxynucleotides improve end-organ tissue injury and survival in septic mice

Matsuda Naoyuki, Imbaby Samar, Hattori Kohshi, Hattori Yuichi

FASEB JOURNAL   Vol. 34   2020.4

Delving into the caregiver burden associated basic activity of daily living disability among caregivers of patients with mild-to-moderate Alzheimer's disease

Kawaharada Rika, Sugimoto Taiki, Tsuboi Yamato, Matsuda Naoka, Sakurai Takashi, Ono Rei

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 20 ( 3 ) page： 263 - 265   2020.3

Relationship Between Serum Norepinephrine Levels at ICU Admission and the Risk of ICU-Acquired Delirium: Secondary Analysis of the Melatonin Evaluation of Lowered Inflammation of ICU Trial.

Yasuda Y, Nishikimi M, Nishida K, Takahashi K, Numaguchi A, Higashi M, Matsui S, Matsuda N

Critical care explorations   Vol. 2 ( 2 ) page： e0082   2020.2

Clinical Frailty Scale Score Before ICU Admission Is Associated With Mobility Disability in Septic Patients Receiving Early Rehabilitation.

Nakajima H, Nishikimi M, Shimizu M, Hayashi K, Inoue T, Nishida K, Takahashi K, Matsui S, Nishida Y, Matsuda N

Critical care explorations   Vol. 1 ( 12 ) page： e0066   2019.12

External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management.

Nishikimi M, Ogura T, Nishida K, Takahashi K, Nakamura M, Matsui S, Matsuda N, Iwami T

Resuscitation   Vol. 140   page： 135-141   2019.5

Timing of administration of epinephrine predicts the responsiveness to epinephrine in norepinephrine-refractory septic shock: a retrospective study

Kasugai Daisuke, Nishikimi Mitsuaki, Nishida Kazuki, Higashi Michiko, Yamamoto Takanori, Numaguchi Atsushi, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

JOURNAL OF INTENSIVE CARE   Vol. 7   page： 20   2019.4

miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury.

Funahashi Y, Kato N, Masuda T, Nishio F, Kitai H, Ishimoto T, Kosugi T, Tsuboi N, Matsuda N, Maruyama S, Kadomatsu K

Laboratory investigation; a journal of technical methods and pathology     2019.1

Hemodynamics of cardiac tamponade during extracorporeal membrane oxygenation support in a patient with fulminant myocarditis.

Kondo T, Morimoto R, Yokoi T, Yamaguchi S, Kuwayama T, Haga T, Hiraiwa H, Sugiura Y, Watanabe N, Kano N, Ichii T, Fukaya K, Sawamura A, Okumura T, Yoshizumi T, Mutsuga M, Fujimoto K, Matsuda N, Usui A, Murohara T

Journal of cardiology cases   Vol. 19 ( 1 ) page： 22-24   2019.1

Different involvement of the MAPK family in inflammatory regulation in human pulmonary microvascular endothelial cells stimulated with LPS and IFN-gamma

Suzuki Tokiko, Sakata Kimimasa, Mizuno Natsumi, Palikhe Sailesh, Yamashita Shigeyuki, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

IMMUNOBIOLOGY   Vol. 223 ( 12 ) page： 777-785   2018.12

Sleep, the Missing Link? Reply

Nishikimi Mitsuaki, Numaguchi Atsushi, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

CRITICAL CARE MEDICINE   Vol. 46 ( 12 ) page： E1225-E1226   2018.12

Early Administration of Ramelteon in the ICU: Effects Deserve Further Study Reply

Nishikimi Mitsuaki, Numaguchi Atsushi, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

CRITICAL CARE MEDICINE   Vol. 46 ( 10 ) page： E1010-E1011   2018.10

Anti-inflammatory properties of cilostazol: Its interruption of DNA binding activity of NF-kappa B from the Toll-like receptor signaling pathways

Sakamoto Takuya, Ohashi Wakana, Tomita Kengo, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

INTERNATIONAL IMMUNOPHARMACOLOGY   Vol. 62   page： 120 - 131   2018.9

Cardioprotective and functional effects of levosimendan and milrinone in mice with cecal ligation and puncture-induced sepsis

Yamashita Shigeyuki, Suzuki Tokiko, Iguchi Keisuke, Sakamoto Takuya, Tomita Kengo, Yokoo Hiroki, Sakai Mari, Misawa Hiroki, Hattori Kohshi, Nagata Toshi, Watanabe Yasuhide, Matsuda Naoyuki, Yoshimura Naoki, Hattori Yuichi

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY   Vol. 391 ( 9 ) page： 1021-1032   2018.9

Nucleic-acid based gene therapy approaches for sepsis

Hattori Yuichi, Hattori Kohshi, Suzuki Tokiko, Palikhe Sailesh, Matsuda Naoyuki

EUROPEAN JOURNAL OF PHARMACOLOGY   Vol. 833   page： 403-410   2018.8

Promising method for management of venoarterial extracorporeal membrane oxygenation: A case of severe heart failure successfully stabilized by "high-flow/vasodilation method".

Kondo T, Sawamura A, Okumura T, Kano N, Morimoto R, Watanabe N, Hiraiwa H, Kuwayama T, Sugiura Y, Haga T, Yamaguchi S, Fukaya K, Yokoi T, Fujimoto K, Mutsuga M, Yoshizumi T, Matsuda N, Usui A, Murohara T

Journal of cardiology cases   Vol. 18 ( 2 ) page： 81-84   2018.8

Differential effect of mild therapeutic hypothermia depending on the findings of hypoxic encephalopathy on early CT images in patients with post-cardiac arrest syndrome

Nishikimi Mitsuaki, Ogura Takayuki, Nishida Kazuki, Takahashi Kunihiko, Fukaya Kenji, Liu Keibun, Nakamura Mitsunobu, Matsui Shigeyuki, Matsuda Naoyuki

RESUSCITATION   Vol. 128   page： 11-15   2018.7

Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU: A Single-Center Randomized Placebo-Controlled Trial

Nishikimi Mitsuaki, Numaguchi Atsushi, Takahashi Kunihiko, Miyagawa Yasuhiro, Matsui Kota, Higashi Michiko, Makishi Go, Matsui Shigeyuki, Matsuda Naoyuki

CRITICAL CARE MEDICINE   Vol. 46 ( 7 ) page： 1099-1105   2018.7

Role of G protein-coupled receptor kinase 2 in oxidative and nitrosative stress-related neurohistopathological changes in a mouse model of sepsis-associated encephalopathy

Kawakami Masaaki, Hattori Mizuki, Ohashi Wakana, Fujimori Toshio, Hattori Kohshi, Takebe Mariko, Tomita Kengo, Yokoo Hiroki, Matsuda Naoyuki, Yamazaki Mitsuaki, Hattori Yuichi

JOURNAL OF NEUROCHEMISTRY   Vol. 145 ( 6 ) page： 474-488   2018.6

MIR-146A TARGETING SPLENIC MACROPHAGES PREVENTS SEPSIS-INDUCED MULTIPLE ORGAN INJURY INCLUDING ACUTE KIDNEY INJURY

Funahashi Yoshio, Kato Noritoshi, Kitai Hiroki, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Matsuda Naoyuki, Maruyama Shoichi, Kadomatsu Kenji

SHOCK   Vol. 49 ( 6 ) page： 21-21   2018.6

Activator Protein-1 Decoy Oligodeoxynucleotide Transfection Is Beneficial in Reducing Organ Injury and Mortality in Septic Mice

Imaizumi Takahiro, Matsuda Naoyuki, Tomita Kengo, Palikhe Sailesh, Ohashi Wakana, Hattori Kohshi, Hattori Yuichi

CRITICAL CARE MEDICINE   Vol. 46 ( 5 ) page： E435 - E442   2018.5

Inducible nitric oxide synthase during the late phase of sepsis is associated with hypothermia and immune cell migration

Takatani Yudai, Ono Kenji, Suzuki Hiromi, Inaba Masato, Sawad Makoto, Matsuda Naoyuki

LABORATORY INVESTIGATION   Vol. 98 ( 5 ) page： 629-639   2018.5

Accuracy of the first interpretation of early brain CT images for predicting the prognosis of post-cardiac arrest syndrome patients at the emergency department

Nishikimi Mitsuaki, Ogura Takayuki, Matsui Kota, Takahashi Kunihiko, Fukaya Kenji, Liu Keibun, Morita Hideo, Nakamura Mitsunobu, Matsui Shigeyuki, Matsuda Naoyuki

JOURNAL OF INTENSIVE CARE   Vol. 6   page： 26   2018.4

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

Nishida Osamu, Ogura Hiroshi, Egi Moritoki, Fujishima Seitaro, Hayashi Yoshiro, Iba Toshiaki, Imaizumi Hitoshi, Inoue Shigeaki, Kakihana Yasuyuki, Kotani Joji, Kushimoto Shigeki, Masuda Yoshiki, Matsuda Naoyuki, Matsushima Asako, Nakada Taka-aki, Nakagawa Satoshi, Nunomiya Shin, Sadahiro Tomohito, Shime Nobuaki, Yatabe Tomoaki, Hara Yoshitaka, Hayashida Kei, Kondo Yutaka, Sumi Yuka, Yasuda Hideto, Aoyama Kazuyoshi, Azuhata Takeo, Doi Kent, Doi Matsuyuki, Fujimura Naoyuki, Fuke Ryota, Fukuda Tatsuma, Goto Koji, Hasegawa Ryuichi, Hashimoto Satoru, Hatakeyama Junji, Hayakawa Mineji, Hifumi Toru, Higashibeppu Naoki, Hirai Katsuki, Hirose Tomoya, Ide Kentaro, Kaizuka Yasuo, Kan'o Tomomichi, Kawasaki Tatsuya, Kuroda Hiromitsu, Matsuda Akihisa, Matsumoto Shotaro, Nagae Masaharu, Onodera Mutsuo, Ohnuma Tetsu, Oshima Kiyohiro, Saito Nobuyuki, Sakamoto So, Sakuraya Masaaki, Sasano Mikio, Sato Norio, Sawamura Atsushi, Shimizu Kentaro, Shirai Kunihiro, Takei Tetsuhiro, Takeuchi Muneyuki, Takimoto Kohei, Taniguchi Takumi, Tatsumi Hiroomi, Tsuruta Ryosuke, Yama Naoya, Yamakawa Kazuma, Yamashita Chizuru, Yamashita Kazuto, Yoshida Takeshi, Tanaka Hiroshi, Oda Shigeto

JOURNAL OF INTENSIVE CARE   Vol. 6   page： 7   2018.2

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

Nishida Osamu, Ogura Hiroshi, Egi Moritoki, Fujishima Seitaro, Hayashi Yoshiro, Iba Toshiaki, Imaizumi Hitoshi, Inoue Shigeaki, Kakihana Yasuyuki, Kotani Joji, Kushimoto Shigeki, Masuda Yoshiki, Matsuda Naoyuki, Matsushima Asako, Nakada Taka-aki, Nakagawa Satoshi, Nunomiya Shin, Sadahiro Tomohito, Shime Nobuaki, Yatabe Tomoaki, Hara Yoshitaka, Hayashida Kei, Kondo Yutaka, Sumi Yuka, Yasuda Hideto, Aoyama Kazuyoshi, Azuhata Takeo, Doi Kent, Doi Matsuyuki, Fujimura Naoyuki, Fuke Ryota, Fukuda Tatsuma, Goto Koji, Hasegawa Ryuichi, Hashimoto Satoru, Hatakeyama Junji, Hayakawa Mineji, Hifumi Toru, Higashibeppu Naoki, Hirai Katsuki, Hirose Tomoya, Ide Kentaro, Kaizuka Yasuo, Kan'o Tomomichi, Kawasaki Tatsuya, Kuroda Hiromitsu, Matsuda Akihisa, Matsumoto Shotaro, Nagae Masaharu, Onodera Mutsuo, Ohnuma Tetsu, Oshima Kiyohiro, Saito Nobuyuki, Sakamoto So, Sakuraya Masaaki, Sasano Mikio, Sato Norio, Sawamura Atsushi, Shimizu Kentaro, Shirai Kunihiro, Takei Tetsuhiro, Takeuchi Muneyuki, Takimoto Kohei, Taniguchi Takumi, Tatsumi Hiroomi, Tsuruta Ryosuke, Yama Naoya, Yamakawa Kazuma, Yamashita Chizuru, Yamashita Kazuto, Yoshida Takeshi, Tanaka Hiroshi, Oda Shigeto

ACUTE MEDICINE & SURGERY   Vol. 5 ( 1 ) page： 3-89   2018.1

High-Flow Nasal Cannula Therapy for Acute Respiratory Failure in Patients with Interstitial Pneumonia: A Retrospective Observational Study

Omote N., Hashimoto N., Matsuda N., Nishida K., Sakamoto K., Ando A., Nakahara Y., Nishikimi M., Higashi M., Matsui S., Hasegawa Y.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 197   page： .   2018

Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: Novel therapeutic implications and challenges

Hattori Yuichi, Hattori Kohshi, Suzuki Tokiko, Matsuda Naoyuki

PHARMACOLOGY & THERAPEUTICS   Vol. 177   page： 56-66   2017.9

A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS

Yamamoto Seiji, Muramatsu Masashi, Azuma Erika, Ikutani Masashi, Nagai Yoshinori, Sagara Hiroshi, Koo Bon-Nyeo, Kita Satomi, O'Donnell Erin, Osawa Tsuyoshi, Takahashi Hiroyuki, Takano Ken-ichi, Dohmoto Mitsuko, Sugimori Michiya, Usui Isao, Watanabe Yasuhide, Hatakeyama Noboru, Iwamoto Takahiro, Komuro Issei, Takatsu Kiyoshi, Tobe Kazuyuki, Niida Shumpei, Matsuda Naoyuki, Shibuya Masabumi, Sasahara Masakiyo

SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page： 3855   2017.6

Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: attribution to phosphodiesterase 4 upregulation

Sakai Mari, Suzuki Tokiko, Tomita Kengo, Yamashita Shigeyuki, Palikhe Sailesh, Hattori Kohshi, Yoshimura Naoki, Matsuda Naoyuki, Hattori Yuichi

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   Vol. 312 ( 6 ) page： H1224-H1237   2017.6

Plasmapheresis therapy has no triglyceride-lowering effect in patients with hypertriglyceridemic pancreatitis

Miyamoto Kyohei, Horibe Masayasu, Sanui Masamitsu, Sasaki Mitsuhito, Sugiyama Daisuke, Kato Seiya, Yamashita Takahiro, Goto Takashi, Iwasaki Eisuke, Shirai Kunihiro, Oe Kyoji, Sawano Hirotaka, Oda Takuya, Yasuda Hideto, Ogura Yuki, Hirose Kaoru, Kitamura Katsuya, Chiba Nobutaka, Ozaki Tetsu, Oshima Taku, Yamamoto Tomonori, Nagata Keiji, Mine Tetsuya, Saito Koji, Sekino Motohiro, Furuya Tomoki, Matsuda Naoyuki, Hayakawa Mineji, Kanai Takanori, Mayumi Toshihiko

INTENSIVE CARE MEDICINE   Vol. 43 ( 6 ) page： 949-951   2017.6

A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score

Nishikimi Mitsuaki, Matsuda Naoyuki, Matsui Kota, Takahashi Kunihiko, Ejima Tadashi, Liu Keibun, Ogura Takayuki, Higashi Michiko, Umino Hitoshi, Makishi Go, Numaguchi Atsushi, Matsushima Satoru, Tokuyama Hideki, Nakamura Mitsunobu, Matsui Shigeyuki

SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE   Vol. 25 ( 1 ) page： 49   2017.5

Regulation of the Cardiovascular System by Histamine

Hattori Yuichi, Hattori Kohshi, Matsuda Naoyuki

HISTAMINE AND HISTAMINE RECEPTORS IN HEALTH AND DISEASE   Vol. 241   page： 239-258   2017

CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracy

Nishikimi Mitsuaki, Matsuda Naoyuki, Matsui Kota, Takahashi Kunihiko, Ejima Tadashi, Liu Keibun, Ogura Takayuki, Higashi Michiko, Umino Hitoshi, Makishi Go, Numaguchi Atsushi, Matsushima Satoru, Tokuyama Hideki, Nakamura Mitsunobu, Matsui Shigeyuki

INTENSIVE CARE MEDICINE   Vol. 42 ( 12 ) page： 2106-2107   2016.12

Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis.

Hattori M, Yamazaki M, Ohashi W, Tanaka S, Hattori K, Todoroki K, Fujimori T, Ohtsu H, Matsuda N, Hattori Y

Intensive care medicine experimental   Vol. 4 ( 1 ) page： 36   2016.12

In vitro reduction of antibacterial activity of tigecycline against multidrug-resistant Acinetobacter baumannii with host stress hormone norepinephrine

Inaba Masato, Matsuda Naoyuki, Banno Hirotsugu, Jin Wanchun, Wachino Jun-ichi, Yamada Keiko, Kimura Kouji, Arakawa Yoshichika

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS   Vol. 48 ( 6 ) page： 680-689   2016.12

The International Activities in Taiwan by the Joint Burn Care Assistance Team of Physicians from Japan Medical Association and Three Medical Societies.

Matsuda N, Yamada S, Hinoshita T, Sasaki J, Ikeda H, Harunari N, Sakamoto T

Japan Medical Association journal : JMAJ   Vol. 59 ( 1 ) page： 12-16   2016.7

[Severe infection in critical emergency care].

Matsuda N, Takatani Y, Higashi T, Inaba M, Ejima T

Nihon rinsho. Japanese journal of clinical medicine   Vol. 74 ( 2 ) page： 245-51   2016.2

Alert cell strategy in SIRS-induced vasculitis: sepsis and endothelial cells

Matsuda Naoyuki

JOURNAL OF INTENSIVE CARE   Vol. 4   page： 21   2016

Anti-Inflammatory Profile of Levosimendan in Cecal Ligation-Induced Septic Mice and in Lipopolysaccharide-Stimulated Macrophages

Wang Qiang, Yokoo Hiroki, Takashina Michinori, Sakata Kimimasa, Ohashi Wakana, Abedelzaher Lobna A., Imaizumi Takahiro, Sakamoto Takuya, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

CRITICAL CARE MEDICINE   Vol. 43 ( 11 ) page： E508 - E520   2015.11

Radial artery cannulation decreases the distal arterial blood flow measured by power Doppler ultrasound

Numaguchi Atsushi, Adachi Yushi U., Aoki Yoshitaka, Ishii Yasuhiro, Suzuki Katsumi, Obata Yukako, Sato Shigehito, Nishiwaki Kimitoshi, Matsuda Naoyuki

JOURNAL OF CLINICAL MONITORING AND COMPUTING   Vol. 29 ( 5 ) page： 653-657   2015.10

New drug discovery for surviving sepsis from multiple organ failure

Matsuda Naoyuki

JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 128 ( 3 ) page： S44-S44   2015.7

Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes

Yamamoto Seiji, Niida Shumpei, Azuma Erika, Yanagibashi Tsutomu, Muramatsu Masashi, Huang Ting Ting, Sagara Hiroshi, Higaki Sayuri, Ikutani Masashi, Nagai Yoshinori, Takatsu Kiyoshi, Miyazaki Kenji, Hamashima Takeru, Mori Hisashi, Matsuda Naoyuki, Ishii Yoko, Sasahara Masakiyo

SCIENTIFIC REPORTS   Vol. 5   page： 8505   2015.2

Ultrasonography-guided radial artery catheterization and further optimal sequences

Adachi Yushi U., Numaguchi Atsushi, Matsuda Naoyuki

JOURNAL OF CLINICAL MONITORING AND COMPUTING   Vol. 29 ( 1 ) page： 201-202   2015.2

Lingual tonsil hypertrophy diagnosed by post-mortem computed tomography in a difficult airway case

Hinoshita T., Numaguchi A., Adachi Y. U., Nakahara K., Matsuda N.

ACTA ANAESTHESIOLOGICA SCANDINAVICA   Vol. 58 ( 9 ) page： 1162-1163   2014.10

Continuous administration of landiolol reduced QT dispersion in postoperative patients

Suzuki Katsumi, Numaguchi Atsushi, Adachi Yushi U., Obata Yukako, Hatano Toshiyuki, Ejima Tadashi, Sato Shigehito, Matsuda Naoyuki

JOURNAL OF CLINICAL ANESTHESIA   Vol. 26 ( 6 ) page： 438-442   2014.9

Ubiquitin is phosphorylated by PINK1 to activate parkin

Koyano Fumika, Okatsu Kei, Kosako Hidetaka, Tamura Yasushi, Go Etsu, Kimura Mayumi, Kimura Yoko, Tsuchiya Hikaru, Yoshihara Hidehito, Hirokawa Takatsugu, Endo Toshiya, Fon Edward A., Trempe Jean-Francois, Saeki Yasushi, Tanaka Keiji, Matsuda Noriyuki

NATURE   Vol. 510 ( 7503 ) page： 162-+   2014.6

Not only bupivacaine but also propofol is sinking in lipid?

Adachi Yushi U., Numaguchi Atsushi, Matsuda Naoyuki

JOURNAL OF ANESTHESIA   Vol. 28 ( 3 ) page： 476-476   2014.6

Alert Cell Strategy: Mechanisms of Inflammatory Response and Organ Protection. Reviewed

Noboru Hatakeyama, Naoyuki Matsuda

Curr Pharm Des   Vol. 20   page： 5766-5778   2014.2

Alert cell strategy: mechanisms of inflammatory response and organ protection.

Hatakeyama N, Matsuda N

Current pharmaceutical design   Vol. 20 ( 36 ) page： 5766-78   2014

The Japanese guidelines for the management of sepsis.

Oda S, Aibiki M, Ikeda T, Imaizumi H, Endo S, Ochiai R, Kotani J, Shime N, Nishida O, Noguchi T, Matsuda N, Hirasawa H, Sepsis Registry Committee of The Japanese Society of Intensive Care Medicine.

Journal of intensive care   Vol. 2 ( 1 ) page： 55   2014

Alert Cell Strategy: Mechanisms of Inflammatory Response and Organ Protection

Hatakeyama Noboru, Matsuda Naoyuki

CURRENT PHARMACEUTICAL DESIGN   Vol. 20 ( 36 ) page： 5766-5778   2014

Landiolol reduces hemodynamic responses to bronchoscopy-assisted suctioning in intubated ICU patients.

Tochikubo J, Adachi YU, Ejima T, Numaguchi A, Matsuda N, Sato S, Shiiya N

Journal of intensive care   Vol. 2 ( 1 ) page： 6   2014

The advanced radial artery cannulation using Insyte-A (TM) with real-time ultrasound guidance

Adachi Yushi U., Hatano Toshiyuki, Hashimoto Shinsuke, Ejima Tadashi, Murase Kichiro, Matsuda Naoyuki

JOURNAL OF CLINICAL MONITORING AND COMPUTING   Vol. 27 ( 6 ) page： 703-704   2013.12

BUNDLE-BASED MANAGEMENT OF SEPTIC SHOCK IN NAGOYA UNIVERSITY EMERGENCY AND MEDICAL ICU

Matsuda N., Matsushima S., Hashimoto S., Ejima M., Takatani Y., Higashi M., Inaba M., Ohbayashi M., Asada K., Umino J., Hinoshita T., Numaguchi A., Kado M., Adachi Y., Takahashi H.

INTENSIVE CARE MEDICINE   Vol. 39   page： S480-S480   2013.10

INFLAMMATION-INDUCED AUTOPHAGY HUMAN VASCULAR ENDOTHELIAL CELLS

Matsuda N., Konishi Y., Itoh R., Tochikubo J., Adachi Y.

INTENSIVE CARE MEDICINE   Vol. 39   page： S239-S240   2013.10

The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons

Koyano Fumika, Okatsu Kei, Ishigaki Shinsuke, Fujioka Yusuke, Kimura Mayumi, Sobue Gen, Tanaka Keiji, Matsuda Noriyuki

GENES TO CELLS   Vol. 18 ( 8 ) page： 672-681   2013.8

Recurarization after sugammadex following a prolonged rocuronium infusion for induced hypothermia

Murata Tetsuya, Kubodera Toshi, Ohbayashi Masakazu, Murase Kichiro, Adachi Yushi U., Matsuda Naoyuki

CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE   Vol. 60 ( 5 ) page： 508-509   2013.5

Intravenous droperidol decreases the bispectral index during general anesthesia with sevoflurane and remifentanil.

Adachi YU, Tanaka K, Suzuki S, Nishiwaki K, Matsuda N

Masui. The Japanese journal of anesthesiology   Vol. 62 ( 1 ) page： 71-4   2013.1

Subcutaneous emphysema and ultrasound sonography.

Kubodera T, Adachi YU, Hatano T, Ejima T, Numaguchi A, Matsuda N

Journal of intensive care   Vol. 1 ( 1 ) page： 8   2013

The effect of aging on dopamine release and metabolism during sevoflurane anesthesia in rat striatum: An in vivo microdialysis study

Kimura-Kuroiwa Kaori, Adachi Yushi U., Mimuro Soichiro, Obata Yukako, Kawamata Mikito, Sato Shigehito, Matsuda Naoyuki

BRAIN RESEARCH BULLETIN   Vol. 89 ( 5-6 ) page： 223-230   2012.12

NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte apoptosis.

Matsuno K, Iwata K, Matsumoto M, Katsuyama M, Cui W, Murata A, Nakamura H, Ibi M, Ikami K, Zhang J, Matoba S, Jin D, Takai S, Matsubara H, Matsuda N, Yabe-Nishimura C

Free radical biology & medicine   Vol. 53 ( 9 ) page： 1718-28   2012.11

[ECG changes after the induction of general anesthesia with remifentanil: a report of three case].

Tanaka K, Adachi Y, Suzuki S, Nishiwaki K, Matsuda N

Masui. The Japanese journal of anesthesiology   Vol. 61 ( 10 ) page： 1128-32   2012.10

TAK-1 SIRNA NORMALIZES AUTOPHAGY AND APOPTOSIS IN SEPTIC MOUSE LUNG

Matsuda N., Tochikubo J., Tamura T., Tsuzuki M., Murase K., Adachi Y.

INTENSIVE CARE MEDICINE   Vol. 38   page： S18-S18   2012.10

MODULATION OF EXPRESSION AND FUNCTION OF ION CHANNELS IN ATRIAL MYOCYTE FROM SEPTIC GUINEA PIG

Hatakeyama N., Aoki Y., Sakakibara K., Matsuda N., Kinoshita H., Fujiwara Y.

INTENSIVE CARE MEDICINE   Vol. 38   page： S103-S103   2012.10

Epidural catheter insertion during general anesthesia

Adachi Yushi U., Matsuda Naoyuki

JOURNAL OF ANESTHESIA   Vol. 26 ( 4 ) page： 633-633   2012.8

Is it constantly possible to penetrate only the anterior vessel wall against hydrostatic strain?

Adachi Yushi U., Tuzuki Michitaka, Matsuda Naoyuki

CRITICAL CARE MEDICINE   Vol. 40 ( 8 ) page： 2534-2535   2012.8

Is it fluid or air causing anesthesia mumps?

Adachi Yushi U., Matsuda Naoyuki

JOURNAL OF ANESTHESIA   Vol. 26 ( 4 ) page： 638-639   2012.8

Evaluating patient self-assessment of health as a predictor of hospital admission in emergency practice: a diagnostic validity study

Miyamichi Ryosuke, Mayumi Toshihiko, Asaoka Mineo, Matsuda Naoyuki

EMERGENCY MEDICINE JOURNAL   Vol. 29 ( 7 ) page： 570-575   2012.7

Isoflurane Pretreatment Preserves Adenosin Triphosphate-Sensitive K+ Channel Function in the Human Artery Exposed to Oxidative Stress Caused by High Glucose Levels

Kinoshita Hiroyuki, Matsuda Naoyuki, Iranami Hiroshi, Ogawa Koji, Hatakeyama Noboru, Azma Toshiharu, Kawahito Shinji, Yamazaki Mitsuaki

ANESTHESIA AND ANALGESIA   Vol. 115 ( 1 ) page： 54-61   2012.7

Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice

Kimura-Kuroiwa Kaori, Adachi Yushi U., Obata Yukako, Kawamata Mikito, Sato Shigehito, Matsuda Naoyuki

JOURNAL OF ANESTHESIA   Vol. 26 ( 3 ) page： 422-428   2012.6

Role of ion channels in sepsis-induced atrial tachyarrhythmias in guinea pigs

Aoki Yuta, Hatakeyama Noboru, Yamamoto Seiji, Kinoshita Hiroyuki, Matsuda Naoyuki, Hattori Yuichi, Yamazaki Mitsuaki

BRITISH JOURNAL OF PHARMACOLOGY   Vol. 166 ( 1 ) page： 390-400   2012.5

Pentobarbital Decreased Nitric Oxide Release in the Rat Striatum but Ketamine Increased the Release Independent of Cholinergic Regulation

Kimura-Kuroiwa Kaori, Adachi Yushi U., Mimuro Soichiro, Kawamata Mikito, Sato Shigehito, Matsuda Naoyuki

EXPERIMENTAL ANIMALS   Vol. 61 ( 2 ) page： 165-170   2012.4

Cochlear Blood Flow and Speech Perception Ability in Cochlear Implant Users

Nakashima Tsutomu, Hattori Taku, Sone Michihiko, Asahi Kiyomitsu, Matsuda Naoko, Teranishi Masaaki, Yoshida Tadao, Kato Ken, Sato Eisuke

OTOLOGY & NEUROTOLOGY   Vol. 33 ( 2 ) page： 165-168   2012.2

The effect of insulin may not be so simple.

Kinoshita H, Matsuda N

Anesthesiology   Vol. 116 ( 2 ) page： 488; author reply 489-90   2012.2

[Sudden increases and decreases in bispectral index values more than 30 within 1 minute during general anesthesia].

Toriyama W, Adachi Y, Obata Y, Sato S, Matsuda N

Masui. The Japanese journal of anesthesiology   Vol. 61 ( 2 ) page： 210-3   2012.2

Roles of neuronal nitric oxide synthase, oxidative stress, and propofol in N-methyl-D-aspartate-induced dilatation of cerebral arterioles

Hama-Tomioka K., Kinoshita H., Nakahata K., Kondo T., Azma T., Kawahito S., Hatakeyama N., Matsuda N.

BRITISH JOURNAL OF ANAESTHESIA   Vol. 108 ( 1 ) page： 21-29   2012.1

ENDOPLASMIC RETICULUM STRESS SENSOR PROTEINS EXPRESSION AND ITS ALTERATION IN SEPSIS DEPEND ON CELL TYPES IN PANCREAS AND ADRENAL GLAND

Suzuki T., Matsuda N., Teramae H., Sato N., Koike K.

SHOCK   Vol. 37   page： 111-111   2012

Pentobarbital decreased nitric oxide release in the rat striatum but ketamine increased the release independent of cholinergic regulation.

Kimura-Kuroiwa K, Adachi YU, Mimuro S, Kawamata M, Sato S, Matsuda N

Experimental animals   Vol. 61 ( 2 ) page： 165-70   2012

[Inflammatory alert cell strategy in septic acute lung injury].

Matsuda N, Tsuzuki M, Ichikawa S, Tochikubo J, Tamura T, Adachi Y

Nihon yakurigaku zasshi. Folia pharmacologica Japonica   Vol. 138 ( 4 ) page： 151-4   2011.10

High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors.

Kageyama S, Yokoo H, Tomita K, Kageyama-Yahara N, Uchimido R, Matsuda N, Yamamoto S, Hattori Y

Cardiovascular diabetology   Vol. 10   page： 73   2011.8

Successful recovery from delayed amniotic fluid embolism with prolonged cardiac resuscitation.

Hosono K, Matsumura N, Matsuda N, Fujiwara H, Sato Y, Konishi I

The journal of obstetrics and gynaecology research   Vol. 37 ( 8 ) page： 1122-5   2011.8

Modification of endotracheal intubation using AirwayScope (TM) videolaryngoscope for straight reinforced tubes

Minonishi T., Kinoshita H., Hirayama M., Hatakeyama N., Matsuda N.

MINERVA ANESTESIOLOGICA   Vol. 77 ( 8 ) page： 850-851   2011.8

LEVELS OF ANTITHROMBIN ACTIVITY AFTER ANTITHROMBIN ADMINISTRATION INDICATE PROGNOSIS OF SEPTIC DIC PATIENTS

Mayumi T., Suzuki S., Yamamoto T., Ichikawa T., Onodera M., Tsuzuki M., Kin B., Inoue T., Kainuma M., Takahashi H., Matsuda N., Nishiwaki K.

SHOCK   Vol. 35   page： 13-13   2011.6

Successful treatment of acute lung injury with pitavastatin in septic mice: potential role of glucocorticoid receptor expression in alveolar macrophages.

Takano K, Yamamoto S, Tomita K, Takashina M, Yokoo H, Matsuda N, Takano Y, Hattori Y

The Journal of pharmacology and experimental therapeutics   Vol. 336 ( 2 ) page： 381-90   2011.2

Issues regarding propofol concentrations within the clinical range.

Kinoshita H, Matsuda N

Anesthesiology   Vol. 114 ( 1 ) page： 218; author reply 218-9   2011.1

Alert cell strategy for inflammation and cell death in septic ALI/ARDS

Matsuda Naoyuki

JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 115   page： 38P - 38P   2011

Origin of the cerebral microvascular pericytes in the neurogenesis period

Yamamoto Seiji, Muramatsu Masashi, Azuma Erika, Dohmoto Mitsuko, Takano Ken-ichi, Kita Satomi, Iwamoto Takahiro, Komuro Issei, Niida Shumpei, Shibuya Masabumi, Matsuda Naoyuki, Hattori Yuichi

JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 115   page： 86P-86P   2011

FADD SIRNA REDUCES AUTOPHAGY AND APOPTOSIS IN SEPTIC MICE

Matsuda Naoyuki, Teramae Hiroki

CRITICAL CARE MEDICINE   Vol. 38 ( 12 ) page： U20-U20   2010.12

Insights Into Sepsis Therapeutic Design Based on the Apoptotic Death Pathway

Hattori Yuichi, Takano Ken-ichi, Teramae Hiroki, Yamamoto Seiji, Yokoo Hiroki, Matsuda Naoyuki

JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 114 ( 4 ) page： 354-365   2010.12

MODULATION ON EXPRESSION AND FUNCTION OF CALCIUM AND POTASSIUM CHANNELS IN SEPTIC GUINEA PIG ATRIUM

Hatakeyama Noboru, Aoki Yuta, Kinoshita Hiroyuki, Matsuda Naoyuki, Yamazaki Mitsuaki

CRITICAL CARE MEDICINE   Vol. 38 ( 12 ) page： U51-U51   2010.12

Endothelial detachment, caused by low-shear stress and resulting in neointima formation in mice

Tsuzuki M., Matsuda N., Okumura K., Murohara T.

EUROPEAN HEART JOURNAL   Vol. 31   page： 403-404   2010.9

The Modulation of Vascular ATP-Sensitive K+ Channel Function via the Phosphatidylinositol 3-Kinase-Akt Pathway Activated by Phenylephrine

Haba Masanori, Hatakeyama Noboru, Kinoshita Hiroyuki, Teramae Hiroki, Azma Toshiharu, Hatano Yoshio, Matsuda Naoyuki

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS   Vol. 334 ( 2 ) page： 673-678   2010.8

Up-regulation of histamine H4 receptors contributes to splenic apoptosis in septic mice: counteraction of the antiapoptotic action of nuclear factor-kappaB.

Matsuda N, Teramae H, Futatsugi M, Takano K, Yamamoto S, Tomita K, Suzuki T, Yokoo H, Koike K, Hattori Y

The Journal of pharmacology and experimental therapeutics   Vol. 332 ( 3 ) page： 730-7   2010.3

Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells

Zhang Xiao-Hong, Yokoo Hiroki, Nishioka Hiroshi, Fujii Hajime, Matsuda Naoyuki, Hayashi Toshio, Hattori Yuichi

BRITISH JOURNAL OF PHARMACOLOGY   Vol. 159 ( 4 ) page： 928-938   2010.2

Tracheal intubation with the AirwayScope videolaryngoscope using straight vs curved reinforced tubes.

Minonishi T, Kinoshita H, Tange K, Hatakeyama N, Matsuda N, Azma T, Hatano Y

Canadian journal of anaesthesia = Journal canadien d'anesthesie   Vol. 57 ( 1 ) page： 92-3   2010.1

Increased death receptor pathway of apoptotic signaling in septic mouse aorta: effect of systemic delivery of FADD siRNA.

Matsuda N, Teramae H, Yamamoto S, Takano K, Takano Y, Hattori Y

American journal of physiology. Heart and circulatory physiology   Vol. 298 ( 1 ) page： H92-101   2010.1

Possible involvement of brain cytokines-modulating signaling pathways in hypothalamus in encephalopathy and development of sepsis in mice

Imai Satoshi, Narita Minoru, Ishiwata Sayuri, Narita Michiko, Honda Natsuki, Niikura Keiichi, Kuzumaki Naoko, Matsuda Naoyuki, Suzuki Tsutomu

JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 112   page： 25P-25P   2010

Possible involvement of central cytokines and chemokines in the development of sepsis following cecal ligation and puncture in mice

Ishiwata Sayuri, Narita Minoru, Narita Michiko, Honda Natsuki, Imai Satoshi, Niikura Keiichi, Kuzumaki Naoko, Matsuda Naoyuki, Suzuki Tsutomu

JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 112   page： 107P-107P   2010

Insights into sepsis therapeutic design based on the apoptotic death pathway.

Hattori Y, Takano K, Teramae H, Yamamoto S, Yokoo H, Matsuda N

Journal of pharmacological sciences   Vol. 114 ( 4 ) page： 354-65   2010

敗血症病態における心筋細胞内Ca2+動態の解析

2017.4 - 2019.3

科学研究費補助金  基盤研究(C)

Drug discovery for improvement of positive inotropic effect in septic myocardial injury

2015.4 - 2017.4

Grant-in-Aid for Scientific Research 

Drug discovery platform for improvement of positive inotropic effect in septic myocardium

Grant number：15K15661  2015.4 - 2017.3

Matsuda Naoyuki

敗血症性多臓器不全における主要臓器再生への遺伝子治療とiPS細胞の応用

2013.4 - 2017.3

科学研究費補助金  基盤研究(B)

Gene therapy and application of iPS cells to major organ regeneration in septic multiple organ failure

Grant number：25293365  2013.4 - 2017.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

Matsuda Naoyuki

Analysis using knock-down methods for gene-associated receptor signaling in sepsis

Grant number：23659843  2011 - 2012

Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

MATSUDA Naoyuki

敗血症病態に合併するタンパク異化病態の分子生化学的解明と遺伝子治療の開発

2010.4 - 2012.3

科学研究費補助金  基盤研究(A)

松田直之

Role of Autophagy and the Molecule Targeting in Sepsis

Grant number：22249059  2010 - 2012

MATSUDA Naoyuki

Bio-Marker of Severe Sepsis in Super-Senior Citizens

2009.9 - 2010.3

Grant-in-Aid for Scientific Research 

Detection of Circulating Endothelial Cells in Severe Sepsis

Grant number：21390482  2009 - 2011

KOIKE Kaoru

Role of Bone Marrow Derived Stem Cells for Repair of Multiple Organs in Severe Sepsis

2008.4 - 2010.3

Grant-in-Aid for Scientific Research 

The transcription factor AP-1 as a molecular target in sepsis therapy

Grant number：20590250  2008 - 2010

HATTORI Yuichi

Gene Therapy of Severe Sepsis

2007.4 - 2010.3

Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(B)

Analysis of cerebral microcirculatory regulation in relation to anesthetics and gene therapy using the live-cell imaging

Grant number：19390409  2007 - 2010

KINOSHITA Hiroyuki

急性腎不全の管理

2010

急性期抗菌薬の適正使用

2010

急性期栄養管理の学術とポイント

2010

敗血症の病態生理学的研究と創薬

2010

人工呼吸器のモニタリング

2010

教養科目　生命科学と現代医療

2021

特別講義　急性期多臓器不全の全身管理と研究

2021

救急医学

2021

現代医療と生命科学

2021

現代医療と生命科学

2019

Life Sciences and Modern Medicine

2011

麻酔科学「呼吸管理」

2009.4 - 2010.3 （富山大学医学部）

呼吸器内科「急性肺障害の診断と治療」

2009.4 - 2010.3 （富山大学医学部）

臨床薬理学「救急・集中治療におけるEBMの実践」

2009.4 - 2010.3 （富山大学医学部）

早期体験学習「救急・集中治療」

2009.4 - 2010.3 （星薬科大学）

大学院特別講義

2019.4 - 2020.3 （University of Shizuoka）

大学院特別講義

2019.4 - 2020.3 （University of Toyama）