Updated on 2021/11/02

写真a

 
MATSUDA, Naoyuki
 
Organization
Graduate School of Medicine Program in Integrated Medicine Development Professor
Disaster Mitigation Research Center Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor

Degree 1

  1. Doctor of Philosophy ( 2001.3   Hokkaido University ) 

Research Interests 1

  1. systemic inflammatory response syndrome, sepsis, acute lung injury, shock, DIC, MODS, infection, antibiotics, transcriptional factor, NF-kB, AP-1, CREB, STAT, endothelium, vascular, gene therapy, apoptosis, autophagy

Research Areas 5

  1. Life Science / Emergency medicine  / Emergency Medicine and Critical Care Medicine

  2. Life Science / Anesthesiology  / Anesthesiology

  3. Life Science / Emergency medicine  / Critical Care Medicine

  4. Life Science / Pharmacology  / Pharmacology

  5. Life Science / Infectious disease medicine  / 感染症管理

Current Research Project and SDGs 4

  1. Pathophysiology of Severe Sepsis

  2. Mecular control of interleukin-6 receptor signaling in systemic inflammation

  3. Gene Therapy: Construction of cell regeneration theory in septic shock

  4. Gene Regulation of Protein Catabolism in Systemic Inflammatory Response State

Research History 10

  1. Nagoya University   Professor in Nagoya University Disaster Mitigation Research Center

    2010.12

  2. Department of Emergency & Critical Medicine, Nagoya University Graduate School of Medicine

    2010.2

      More details

    Country:Japan

  3. 京都大学大学院医学研究科・初期診療・救急医学分野・准教授

    2007.9 - 2010.1

      More details

    Country:Japan

  4. 富山大学医学部附属病院麻酔科・診療教授

    2007.1 - 2007.8

      More details

    Country:Japan

  5. 富山大学医学薬学研究部分子医科薬理学講座・准教授

    2006.2 - 2007.8

      More details

    Country:Japan

  6. 北海道大学大学院医学研究科・救急医学分野・学内講師

    2004.4 - 2006.1

      More details

    Country:Japan

  7. 北海道大学病院 救急部・集中治療部・助手

    2000.10 - 2006.1

      More details

    Country:Japan

  8. 北海道大学医学部附属病院 救急部・集中治療部・医員

    2000.4 - 2000.9

      More details

    Country:Japan

  9. 北海道砂川市立病院・医員

    1994.4 - 1995.3

      More details

    Country:Japan

  10. 北海道大学医学部附属病院・研修医

    1993.4 - 1994.3

      More details

    Country:Japan

▼display all

Education 2

  1. Hokkaido University   Graduate School, Division of Medicine   Surgery

    1995.4 - 2001.3

      More details

    Country: Japan

  2. Hokkaido University   Faculty of Medicine   Division of Medicine

    1986.4 - 1993.3

      More details

    Country: Japan

Professional Memberships 29

  1. 日本集中治療医学会   理事

    2014.3

  2. 日本救急医学会   評議員

    2016.4

  3. 日本心臓血管麻酔学会   理事

    2013.9

  4. 日本心臓血管麻酔学会   集中治療部会・委員長

    2015.4

  5. Journal of Cardiothoracic and Vascular Anesthesia   Editorial Board

    2010.4

  6. 日本集中治療医学会   集中治療薬剤委員会・委員長

    2021.4

  7. 日本集中治療医学会   広報委員会・委員長

    2014.4

  8. 日本集中治療医学会   Global Sepsis Alliance委員会・担当理事

    2019.1

  9. 日本救急医学会中部地方会   理事

    2011.4

  10. 日本臨床麻酔学会   理事

    2010.4

  11. 日本感染症学会

  12. 日本化学療法学会

  13. 日本外傷学会

  14. 日本呼吸器学会

  15. 日本薬理学会   評議員

    2005.4 - 2006.3

  16. 日本炎症・再生医学会

  17. 日本ペインクリニック学会

  18. Japanese Society of Intensive Care Medicine   Chairman of International Committee

    2013.4 - 2017.3

  19. 日本心臓血管麻酔学会   編集委員長

    2011.4 - 2016.3

  20. 日本集中治療医学会   専門医委員会 委員

    2010.4 - 2011.3

  21. 日本臨床麻酔学会   査読委員

    2007.4

  22. 日本外科感染症学   医の質・安全委員会 副委員長

    2007.4

  23. 日本循環制御医学会   機関誌編集委員

    2007.4 - 2013.3

  24. the Society of Critical Care Medicine   Internal Medicine Section member

    2007.4 - 2008.3

  25. 日本外科感染症学会誌   編集委員・査読委員

    2006.4 - 2012.3

  26. 日本心臓血管麻酔学会   文献レビュー委員会 委員長

    2006.4 - 2010.3

  27. 日本集中治療医学会   評議員

    2005.4

  28. 日本麻酔科学会   評議員

    2005.4 - 2010.3

  29. American Society of Anesthesiologist

▼display all

Committee Memberships 3

  1. 救急外来及び救急・内科系集中治療部運営協議会   議長  

    2011.4   

  2. 災害対策専門委員会   委員長  

    2013.4   

  3. 移植検討委員会   委員長  

    2012.4   

Awards 10

  1. 日本麻酔科学会 第28回山村記念賞

    2009.8   日本麻酔科学会  

     More details

    Country:Japan

    敗血症病態における転写因子NF-kBの機能解析

  2. 2009年日本集中治療医学会 優秀論文賞

    2010.3   日本集中治療医学会  

     More details

    Country:Japan

    Nuclear factor-κB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis. Crit Care Med 37:2791-2799,2009.

  3. 39th米国集中治療医学会 Annual Scientific Award

    2010.1   米国集中治療医学会  

     More details

    Inhaled TAK1 siRNA Improves Lung Inflammation and Apoptosis by Reduced Transcriptional Activity of NF-kB and AP-1

  4. 40th米国集中治療医学会 Reserch Citation Award

    2010.1   米国集中治療医学会  

     More details

    Award type:Award from international society, conference, symposium, etc.  Country:United States

  5. 35th米国集中治療医学会 Reserch Citation Award

    2006.1   米国  

  6. 2004年日本集中治療医学会 優秀論文賞

    2005.2   日本集中治療医学会  

     More details

    Country:Japan

    Therapeutic effect of in vivo transfection of transcription factor decoy to NF-kB on septic lung in mice. Am J Physiol Lung Cell Mol Physiol 287: L1248-L1255,2004.

  7. 日本ヒスタミン研究会 第1回和田記念賞

    2004.12   日本ヒスタミン研究会  

     More details

    Country:Japan

    敗血症に合併する急性肺障害の増悪機構 ―ヒスタミン受容体発現の変化―

  8. 33th米国集中治療医学会 Annual Scientific Award

    2004.2   米国集中治療医学会  

  9. 日本救急医学会 丸茂賞

    2003.11   日本救急医学会  

     More details

    Country:Japan

  10. 北海道麻酔科学会 第15回高橋賞

    2002.9   北海道麻酔科学会  

     More details

    Country:Japan

▼display all

 

Papers 124

  1. *Regulation of histamine H4 receptors contributes to splenic apoptosis in septic mice: counteraction of the anti-apoptotic action of nuclear factor-kB. Reviewed

    Matsuda N, Teramae H, Futatsugi M, Takano KI, Yamamoto S, Tomita K, Suzuki T, Yokoo H, Koike K, Hattori Y.

    J Pharmacol Exp Ther   Vol. 109   page: 1635-1643   2010.3

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  2. Increased death receptor pathway of apoptotic signaling in septic mouse aorta: effect of systemic delivery of FADD siRNA. Reviewed

    Matsuda N, Teramae H, Yamamoto S, Takano KI, Takano Y, Hattori Y.

    Am J Physiol Heart Circ Physiol   Vol. 298   page: 92-101   2010.1

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  3. *Nuclear factor-kB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis. Reviewed

    Matsuda N, Yamamoto S, Yokoo H, Tobe K, Hattori Y.

    Crit Care Med   Vol. 37   page: 2791-2799   2009.10

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  4. *Silencing of Fas-associated Death Domain Protects Mice from Septic Lung Inflammation and Apoptosis. Reviewed

    Matsuda N,Yamamoto S, Takano KI, Kageyama SI, Kurobe Y, Yoshiwara Y, Takano Y, Hattori Y.

    Am J Respir Crit Care Med   Vol. 79   page: 806-815   2009.6

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  5. Priming by lipopolysaccharide exaggerates acute lung injury and mortality in responses to peptidoglycan through up-regulation of Toll-like receptor-2 expression in mice. Reviewed

    Matsuda N, Yamazaki H, Takano KI, Matsui K, Takano Y, Kemmotsu O, Hattori Y.

    Biochem Pharmacol   Vol. 75   page: 1065-1075   2008.11

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  6. Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea-pig lungs using methylprednisolone. Reviewed

      Vol. 295   page: L998-L1006   2008.11

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  7. Roles of phosphatidylinositol 3-kinase and NADPH oxidase in ATP-sensitive K+ channel function impaired by high glucose in the human artery. Reviewed

    Hypertension   Vol. 52   page: 507-513   2008.5

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  8. *Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock. Reviewed

    Matsuda N,Takano Y,Kageyama S,Hatakeyama N,Shakunaga K,Kitajima I,Yamazaki M,Hattori Y.

    Cardiovasc Res   Vol. 76   page: 132-140   2007.6

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  9. Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: reversal effect of fluvastatin therapy. Reviewed

    Matsuda N,Hayashi Y, Takahashi Y,Hattori Y.

    J Pharmacol Exp Ther   Vol. 319   page: 1348-1354   2006.10

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  10. Role of MIF in acute lung injury in mice with acute pancreatitis complicated by endotoxemia. Reviewed

    Matsuda N,Nishihira J,Takahashi Y,Kennmotsu O,Hattori Y.

    Am J Respir Cell Mol Biol   Vol. 35   page: 198-205   2006.7

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  11. *Nuclear Factor-kB decoy oligonucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis. Reviewed

    Matsuda N,Hattori Y,Takahashi Y,Subrina Jesmin,Gando S.

    Mol Pharmacol   Vol. 67   page: 1018-1025   2005.5

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  12. Therapeutic effect of in vivo transfection of transcription factor decoy to NF-kB on septic lung in mice.

    Matsuda N,Hattori Y,Takahashi Y,Nishihira J,Jesmin S,Kobayashi M,Gando S.

    Am J Physiol Lung Cell Mol Physiol   Vol. 287   page: L1248-L1255   2004.4

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  13. The modulation of vascular ATP-sensitive K+ channel function via phosphatidylinositol 3-kinase-Akt pathway activated by phenylephrine. Reviewed

    Haba M, Hatakeyama N, Kinoshita H, Teramae H, Azma T, Hatano Y, Matsuda N.

    J Pharmacol Exp Ther   Vol. 334   page: 673-678   2010.9

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  14. Clinical paper The rCAST score is useful for estimating the neurological prognosis in pediatric patients with post-cardiac arrest syndrome before ICU admission: External validation study using a nationwide prospective registry

    Yasuda Yuma, Nishikimi Mitsuaki, Matsui Kota, Numaguchi Atsushi, Nishida Kazuki, Emoto Ryo, Matsui Shigeyuki, Matsuda Naoyuki

    RESUSCITATION   Vol. 168   page: 103 - 109   2021.11

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.resuscitation.2021.09.025

    Web of Science

    PubMed

  15. Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock

    Hiraiwa Hiroaki, Kasugai Daisuke, Ozaki Masayuki, Goto Yukari, Jingushi Naruhiro, Higashi Michiko, Nishida Kazuki, Kondo Toru, Furusawa Kenji, Morimoto Ryota, Okumura Takahiro, Matsuda Naoyuki, Matsui Shigeyuki, Murohara Toyoaki

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 18823   2021.9

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-98397-8

    Web of Science

    PubMed

  16. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).

    Egi M, Ogura H, Yatabe T, Atagi K, Inoue S, Iba T, Kakihana Y, Kawasaki T, Kushimoto S, Kuroda Y, Kotani J, Shime N, Taniguchi T, Tsuruta R, Doi K, Doi M, Nakada TA, Nakane M, Fujishima S, Hosokawa N, Masuda Y, Matsushima A, Matsuda N, Yamakawa K, Hara Y, Sakuraya M, Ohshimo S, Aoki Y, Inada M, Umemura Y, Kawai Y, Kondo Y, Saito H, Taito S, Takeda C, Terayama T, Tohira H, Hashimoto H, Hayashida K, Hifumi T, Hirose T, Fukuda T, Fujii T, Miura S, Yasuda H, Abe T, Andoh K, Iida Y, Ishihara T, Ide K, Ito K, Ito Y, Inata Y, Utsunomiya A, Unoki T, Endo K, Ouchi A, Ozaki M, Ono S, Katsura M, Kawaguchi A, Kawamura Y, Kudo D, Kubo K, Kurahashi K, Sakuramoto H, Shimoyama A, Suzuki T, Sekine S, Sekino M, Takahashi N, Takahashi S, Takahashi H, Tagami T, Tajima G, Tatsumi H, Tani M, Tsuchiya A, Tsutsumi Y, Naito T, Nagae M, Nagasawa I, Nakamura K, Nishimura T, Nunomiya S, Norisue Y, Hashimoto S, Hasegawa D, Hatakeyama J, Hara N, Higashibeppu N, Furushima N, Furusono H, Matsuishi Y, Matsuyama T, Minematsu Y, Miyashita R, Miyatake Y, Moriyasu M, Yamada T, Yamada H, Yamamoto R, Yoshida T, Yoshida Y, Yoshimura J, Yotsumoto R, Yonekura H, Wada T, Watanabe E, Aoki M, Asai H, Abe T, Igarashi Y, Iguchi N, Ishikawa M, Ishimaru G, Isokawa S, Itakura R, Imahase H, Imura H, Irinoda T, Uehara K, Ushio N, Umegaki T, Egawa Y, Enomoto Y, Ota K, Ohchi Y, Ohno T, Ohbe H, Oka K, Okada N, Okada Y, Okano H, Okamoto J, Okuda H, Ogura T, Onodera Y, Oyama Y, Kainuma M, Kako E, Kashiura M, Kato H, Kanaya A, Kaneko T, Kanehata K, Kano KI, Kawano H, Kikutani K, Kikuchi H, Kido T, Kimura S, Koami H, Kobashi D, Saiki I, Sakai M, Sakamoto A, Sato T, Shiga Y, Shimoto M, Shimoyama S, Shoko T, Sugawara Y, Sugita A, Suzuki S, Suzuki Y, Suhara T, Sonota K, Takauji S, Takashima K, Takahashi S, Takahashi Y, Takeshita J, Tanaka Y, Tampo A, Tsunoyama T, Tetsuhara K, Tokunaga K, Tomioka Y, Tomita K, Tominaga N, Toyosaki M, Toyoda Y, Naito H, Nagata I, Nagato T, Nakamura Y, Nakamori Y, Nahara I, Naraba H, Narita C, Nishioka N, Nishimura T, Nishiyama K, Nomura T, Haga T, Hagiwara Y, Hashimoto K, Hatachi T, Hamasaki T, Hayashi T, Hayashi M, Hayamizu A, Haraguchi G, Hirano Y, Fujii R, Fujita M, Fujimura N, Funakoshi H, Horiguchi M, Maki J, Masunaga N, Matsumura Y, Mayumi T, Minami K, Miyazaki Y, Miyamoto K, Murata T, Yanai M, Yano T, Yamada K, Yamada N, Yamamoto T, Yoshihiro S, Tanaka H, Nishida O

    Journal of intensive care   Vol. 9 ( 1 ) page: 53   2021.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40560-021-00555-7

    PubMed

  17. Impact of a long-term high-glucose environment on pro-inflammatory responses in macrophages stimulated with lipopolysaccharide

    Suzuki Tokiko, Yamashita Shigeyuki, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY     2021.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00210-021-02137-8

    Web of Science

    PubMed

  18. Outcome Related to Level of Targeted Temperature Management in Postcardiac Arrest Syndrome of Low, Moderate, and High Severities: A Nationwide Multicenter Prospective Registry

    Nishikimi Mitsuaki, Ogura Takayuki, Nishida Kazuki, Hayashida Kei, Emoto Ryo, Matsui Shigeyuki, Matsuda Naoyuki, Iwami Taku

    CRITICAL CARE MEDICINE   Vol. 49 ( 8 ) page: E741 - E750   2021.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000005025

    Web of Science

    PubMed

  19. Relative platelet reductions provide better pathophysiologic signatures of coagulopathies in sepsis

    Kasugai Daisuke, Ozaki Masayuki, Nishida Kazuki, Goto Yukari, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 14033   2021.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-93635-5

    Web of Science

    PubMed

  20. Failure of non-invasive respiratory support after 6 hours from initiation is associated with ICU mortality

    Nishikimi Mitsuaki, Nishida Kazuki, Shindo Yuichiro, Shoaib Muhammad, Kasugai Daisuke, Yasuda Yuma, Higashi Michiko, Numaguchi Atsushi, Yamamoto Takanori, Matsui Shigeyuki, Matsuda Naoyuki

    PLOS ONE   Vol. 16 ( 4 ) page: e0251030   2021.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0251030

    Web of Science

    PubMed

  21. A case of reexpansion pulmonary edema and acute pulmonary thromboembolism associated with diffuse large B-cell lymphoma treated with venovenous extracorporeal membrane oxygenation.

    Kazama S, Hiraiwa H, Kimura Y, Ozaki R, Shibata N, Arao Y, Oishi H, Kato H, Kuwayama T, Yamaguchi S, Kondo T, Furusawa K, Morimoto R, Okumura T, Bando YK, Sato T, Shimada K, Kiyoi H, Nakamura G, Yasuda Y, Kasugai D, Ogawa H, Higashi M, Yamamoto T, Jingushi N, Ozaki M, Numaguchi A, Goto Y, Matsuda N, Murohara T

    Journal of cardiology cases   Vol. 23 ( 1 ) page: 53 - 56   2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jccase.2020.08.013

    PubMed

  22. Relative bradycardia as a clinical feature in patients with coronavirus disease 2019 (COVID-19): A report of two cases.

    Hiraiwa H, Goto Y, Nakamura G, Yasuda Y, Sakai Y, Kasugai D, Jinno S, Tanaka T, Ogawa H, Higashi M, Yamamoto T, Jingushi N, Ozaki M, Numaguchi A, Kondo T, Morimoto R, Okumura T, Matsuda N, Murohara T

    Journal of cardiology cases   Vol. 22 ( 6 ) page: 260 - 264   2020.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jccase.2020.07.015

    PubMed

  23. Vascular endothelial growth factor contributes to lung vascular hyperpermeability in sepsis-associated acute lung injury

    Tomita Kengo, Saito Yuna, Suzuki Tokiko, Imbaby Samar, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY   Vol. 393 ( 12 ) page: 2365 - 2374   2020.12

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00210-020-01947-6

    Web of Science

    PubMed

  24. Impact of patient characteristics on the efficacy and safety of landiolol in patients with sepsis-related tachyarrhythmia: Subanalysis of the J-Land 3S randomised controlled study

    Matsuda Naoyuki, Nishida Osamu, Taniguchi Takumi, Okajima Masaki, Morimatsu Hiroshi, Ogura Hiroshi, Yamada Yoshitsugu, Nagano Tetsuji, Ichikawa Akira, Kakihana Yasuyuki

    ECLINICALMEDICINE   Vol. 28   page: 100571   2020.11

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.eclinm.2020.100571

    Web of Science

    PubMed

  25. Beneficial effect of STAT3 decoy oligodeoxynucleotide transfection on organ injury and mortality in mice with cecal ligation and puncture-induced sepsis

    Imbaby Samar, Matsuda Naoyuki, Tomita Kengo, Hattori Kohshi, Palikhe Sailesh, Yokoo Hiroki, Hattori Yuichi

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 15316   2020.9

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-72136-x

    Web of Science

    PubMed

  26. Efficacy and safety of landiolol, an ultra-short-acting beta 1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): a multicentre, open-label, randomised controlled trial

    Kakihana Yasuyuki, Nishida Osamu, Taniguchi Takumi, Okajima Masaki, Morimatsu Hiroshi, Ogura Hiroshi, Yamada Yoshitsugu, Nagano Tetsuji, Morishima Eiichiro, Matsuda Naoyuki

    LANCET RESPIRATORY MEDICINE   Vol. 8 ( 9 ) page: 863 - 872   2020.9

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S2213-2600(20)30037-0

    Web of Science

    PubMed

  27. STAT3 decoy oligodeoxynucleotides improve end-organ tissue injury and survival in septic mice

    Matsuda Naoyuki, Imbaby Samar, Hattori Kohshi, Hattori Yuichi

    FASEB JOURNAL   Vol. 34   2020.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1096/fasebj.2020.34.s1.03240

    Web of Science

  28. Delving into the caregiver burden associated basic activity of daily living disability among caregivers of patients with mild-to-moderate Alzheimer's disease

    Kawaharada Rika, Sugimoto Taiki, Tsuboi Yamato, Matsuda Naoka, Sakurai Takashi, Ono Rei

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 20 ( 3 ) page: 263 - 265   2020.3

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ggi.13862

    Web of Science

  29. Relationship Between Serum Norepinephrine Levels at ICU Admission and the Risk of ICU-Acquired Delirium: Secondary Analysis of the Melatonin Evaluation of Lowered Inflammation of ICU Trial.

    Yasuda Y, Nishikimi M, Nishida K, Takahashi K, Numaguchi A, Higashi M, Matsui S, Matsuda N

    Critical care explorations   Vol. 2 ( 2 ) page: e0082   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCE.0000000000000082

    PubMed

  30. Clinical Frailty Scale Score Before ICU Admission Is Associated With Mobility Disability in Septic Patients Receiving Early Rehabilitation.

    Nakajima H, Nishikimi M, Shimizu M, Hayashi K, Inoue T, Nishida K, Takahashi K, Matsui S, Nishida Y, Matsuda N

    Critical care explorations   Vol. 1 ( 12 ) page: e0066   2019.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCE.0000000000000066

    PubMed

  31. External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management.

    Nishikimi M, Ogura T, Nishida K, Takahashi K, Nakamura M, Matsui S, Matsuda N, Iwami T

    Resuscitation   Vol. 140   page: 135-141   2019.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.resuscitation.2019.05.028

    PubMed

  32. Timing of administration of epinephrine predicts the responsiveness to epinephrine in norepinephrine-refractory septic shock: a retrospective study

    Kasugai Daisuke, Nishikimi Mitsuaki, Nishida Kazuki, Higashi Michiko, Yamamoto Takanori, Numaguchi Atsushi, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

    JOURNAL OF INTENSIVE CARE   Vol. 7   page: 20   2019.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40560-019-0377-1

    Web of Science

    PubMed

  33. miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury.

    Funahashi Y, Kato N, Masuda T, Nishio F, Kitai H, Ishimoto T, Kosugi T, Tsuboi N, Matsuda N, Maruyama S, Kadomatsu K

    Laboratory investigation; a journal of technical methods and pathology     2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41374-019-0190-4

    PubMed

  34. Hemodynamics of cardiac tamponade during extracorporeal membrane oxygenation support in a patient with fulminant myocarditis.

    Kondo T, Morimoto R, Yokoi T, Yamaguchi S, Kuwayama T, Haga T, Hiraiwa H, Sugiura Y, Watanabe N, Kano N, Ichii T, Fukaya K, Sawamura A, Okumura T, Yoshizumi T, Mutsuga M, Fujimoto K, Matsuda N, Usui A, Murohara T

    Journal of cardiology cases   Vol. 19 ( 1 ) page: 22-24   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jccase.2018.08.009

    PubMed

  35. Different involvement of the MAPK family in inflammatory regulation in human pulmonary microvascular endothelial cells stimulated with LPS and IFN-gamma

    Suzuki Tokiko, Sakata Kimimasa, Mizuno Natsumi, Palikhe Sailesh, Yamashita Shigeyuki, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

    IMMUNOBIOLOGY   Vol. 223 ( 12 ) page: 777-785   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.imbio.2018.08.003

    Web of Science

    PubMed

  36. Sleep, the Missing Link? Reply

    Nishikimi Mitsuaki, Numaguchi Atsushi, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

    CRITICAL CARE MEDICINE   Vol. 46 ( 12 ) page: E1225-E1226   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000003452

    Web of Science

    PubMed

  37. Early Administration of Ramelteon in the ICU: Effects Deserve Further Study Reply

    Nishikimi Mitsuaki, Numaguchi Atsushi, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

    CRITICAL CARE MEDICINE   Vol. 46 ( 10 ) page: E1010-E1011   2018.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000003315

    Web of Science

    PubMed

  38. Anti-inflammatory properties of cilostazol: Its interruption of DNA binding activity of NF-kappa B from the Toll-like receptor signaling pathways

    Sakamoto Takuya, Ohashi Wakana, Tomita Kengo, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

    INTERNATIONAL IMMUNOPHARMACOLOGY   Vol. 62   page: 120-131   2018.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.intimp.2018.06.021

    Web of Science

    PubMed

  39. Cardioprotective and functional effects of levosimendan and milrinone in mice with cecal ligation and puncture-induced sepsis

    Yamashita Shigeyuki, Suzuki Tokiko, Iguchi Keisuke, Sakamoto Takuya, Tomita Kengo, Yokoo Hiroki, Sakai Mari, Misawa Hiroki, Hattori Kohshi, Nagata Toshi, Watanabe Yasuhide, Matsuda Naoyuki, Yoshimura Naoki, Hattori Yuichi

    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY   Vol. 391 ( 9 ) page: 1021-1032   2018.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00210-018-1527-z

    Web of Science

    PubMed

  40. Nucleic-acid based gene therapy approaches for sepsis

    Hattori Yuichi, Hattori Kohshi, Suzuki Tokiko, Palikhe Sailesh, Matsuda Naoyuki

    EUROPEAN JOURNAL OF PHARMACOLOGY   Vol. 833   page: 403-410   2018.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ejphar.2018.06.031

    Web of Science

    PubMed

  41. Promising method for management of venoarterial extracorporeal membrane oxygenation: A case of severe heart failure successfully stabilized by "high-flow/vasodilation method".

    Kondo T, Sawamura A, Okumura T, Kano N, Morimoto R, Watanabe N, Hiraiwa H, Kuwayama T, Sugiura Y, Haga T, Yamaguchi S, Fukaya K, Yokoi T, Fujimoto K, Mutsuga M, Yoshizumi T, Matsuda N, Usui A, Murohara T

    Journal of cardiology cases   Vol. 18 ( 2 ) page: 81-84   2018.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jccase.2018.05.002

    PubMed

  42. Differential effect of mild therapeutic hypothermia depending on the findings of hypoxic encephalopathy on early CT images in patients with post-cardiac arrest syndrome

    Nishikimi Mitsuaki, Ogura Takayuki, Nishida Kazuki, Takahashi Kunihiko, Fukaya Kenji, Liu Keibun, Nakamura Mitsunobu, Matsui Shigeyuki, Matsuda Naoyuki

    RESUSCITATION   Vol. 128   page: 11-15   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.resuscitation.2018.04.029

    Web of Science

    PubMed

  43. Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU: A Single-Center Randomized Placebo-Controlled Trial

    Nishikimi Mitsuaki, Numaguchi Atsushi, Takahashi Kunihiko, Miyagawa Yasuhiro, Matsui Kota, Higashi Michiko, Makishi Go, Matsui Shigeyuki, Matsuda Naoyuki

    CRITICAL CARE MEDICINE   Vol. 46 ( 7 ) page: 1099-1105   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000003132

    Web of Science

    PubMed

  44. Role of G protein-coupled receptor kinase 2 in oxidative and nitrosative stress-related neurohistopathological changes in a mouse model of sepsis-associated encephalopathy

    Kawakami Masaaki, Hattori Mizuki, Ohashi Wakana, Fujimori Toshio, Hattori Kohshi, Takebe Mariko, Tomita Kengo, Yokoo Hiroki, Matsuda Naoyuki, Yamazaki Mitsuaki, Hattori Yuichi

    JOURNAL OF NEUROCHEMISTRY   Vol. 145 ( 6 ) page: 474-488   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jnc.14329

    Web of Science

    PubMed

  45. MIR-146A TARGETING SPLENIC MACROPHAGES PREVENTS SEPSIS-INDUCED MULTIPLE ORGAN INJURY INCLUDING ACUTE KIDNEY INJURY

    Funahashi Yoshio, Kato Noritoshi, Kitai Hiroki, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Matsuda Naoyuki, Maruyama Shoichi, Kadomatsu Kenji

    SHOCK   Vol. 49 ( 6 ) page: 21-21   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  46. Activator Protein-1 Decoy Oligodeoxynucleotide Transfection Is Beneficial in Reducing Organ Injury and Mortality in Septic Mice

    Imaizumi Takahiro, Matsuda Naoyuki, Tomita Kengo, Palikhe Sailesh, Ohashi Wakana, Hattori Kohshi, Hattori Yuichi

    CRITICAL CARE MEDICINE   Vol. 46 ( 5 ) page: E435-E442   2018.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000003009

    Web of Science

    PubMed

  47. Inducible nitric oxide synthase during the late phase of sepsis is associated with hypothermia and immune cell migration

    Takatani Yudai, Ono Kenji, Suzuki Hiromi, Inaba Masato, Sawad Makoto, Matsuda Naoyuki

    LABORATORY INVESTIGATION   Vol. 98 ( 5 ) page: 629-639   2018.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41374-018-0021-z

    Web of Science

    PubMed

  48. Accuracy of the first interpretation of early brain CT images for predicting the prognosis of post-cardiac arrest syndrome patients at the emergency department

    Nishikimi Mitsuaki, Ogura Takayuki, Matsui Kota, Takahashi Kunihiko, Fukaya Kenji, Liu Keibun, Morita Hideo, Nakamura Mitsunobu, Matsui Shigeyuki, Matsuda Naoyuki

    JOURNAL OF INTENSIVE CARE   Vol. 6   page: 26   2018.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40560-018-0296-6

    Web of Science

    PubMed

  49. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

    Nishida Osamu, Ogura Hiroshi, Egi Moritoki, Fujishima Seitaro, Hayashi Yoshiro, Iba Toshiaki, Imaizumi Hitoshi, Inoue Shigeaki, Kakihana Yasuyuki, Kotani Joji, Kushimoto Shigeki, Masuda Yoshiki, Matsuda Naoyuki, Matsushima Asako, Nakada Taka-aki, Nakagawa Satoshi, Nunomiya Shin, Sadahiro Tomohito, Shime Nobuaki, Yatabe Tomoaki, Hara Yoshitaka, Hayashida Kei, Kondo Yutaka, Sumi Yuka, Yasuda Hideto, Aoyama Kazuyoshi, Azuhata Takeo, Doi Kent, Doi Matsuyuki, Fujimura Naoyuki, Fuke Ryota, Fukuda Tatsuma, Goto Koji, Hasegawa Ryuichi, Hashimoto Satoru, Hatakeyama Junji, Hayakawa Mineji, Hifumi Toru, Higashibeppu Naoki, Hirai Katsuki, Hirose Tomoya, Ide Kentaro, Kaizuka Yasuo, Kan'o Tomomichi, Kawasaki Tatsuya, Kuroda Hiromitsu, Matsuda Akihisa, Matsumoto Shotaro, Nagae Masaharu, Onodera Mutsuo, Ohnuma Tetsu, Oshima Kiyohiro, Saito Nobuyuki, Sakamoto So, Sakuraya Masaaki, Sasano Mikio, Sato Norio, Sawamura Atsushi, Shimizu Kentaro, Shirai Kunihiro, Takei Tetsuhiro, Takeuchi Muneyuki, Takimoto Kohei, Taniguchi Takumi, Tatsumi Hiroomi, Tsuruta Ryosuke, Yama Naoya, Yamakawa Kazuma, Yamashita Chizuru, Yamashita Kazuto, Yoshida Takeshi, Tanaka Hiroshi, Oda Shigeto

    JOURNAL OF INTENSIVE CARE   Vol. 6   page: 7   2018.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40560-017-0270-8

    Web of Science

    PubMed

  50. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

    Nishida Osamu, Ogura Hiroshi, Egi Moritoki, Fujishima Seitaro, Hayashi Yoshiro, Iba Toshiaki, Imaizumi Hitoshi, Inoue Shigeaki, Kakihana Yasuyuki, Kotani Joji, Kushimoto Shigeki, Masuda Yoshiki, Matsuda Naoyuki, Matsushima Asako, Nakada Taka-aki, Nakagawa Satoshi, Nunomiya Shin, Sadahiro Tomohito, Shime Nobuaki, Yatabe Tomoaki, Hara Yoshitaka, Hayashida Kei, Kondo Yutaka, Sumi Yuka, Yasuda Hideto, Aoyama Kazuyoshi, Azuhata Takeo, Doi Kent, Doi Matsuyuki, Fujimura Naoyuki, Fuke Ryota, Fukuda Tatsuma, Goto Koji, Hasegawa Ryuichi, Hashimoto Satoru, Hatakeyama Junji, Hayakawa Mineji, Hifumi Toru, Higashibeppu Naoki, Hirai Katsuki, Hirose Tomoya, Ide Kentaro, Kaizuka Yasuo, Kan'o Tomomichi, Kawasaki Tatsuya, Kuroda Hiromitsu, Matsuda Akihisa, Matsumoto Shotaro, Nagae Masaharu, Onodera Mutsuo, Ohnuma Tetsu, Oshima Kiyohiro, Saito Nobuyuki, Sakamoto So, Sakuraya Masaaki, Sasano Mikio, Sato Norio, Sawamura Atsushi, Shimizu Kentaro, Shirai Kunihiro, Takei Tetsuhiro, Takeuchi Muneyuki, Takimoto Kohei, Taniguchi Takumi, Tatsumi Hiroomi, Tsuruta Ryosuke, Yama Naoya, Yamakawa Kazuma, Yamashita Chizuru, Yamashita Kazuto, Yoshida Takeshi, Tanaka Hiroshi, Oda Shigeto

    ACUTE MEDICINE & SURGERY   Vol. 5 ( 1 ) page: 3-89   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ams2.322

    Web of Science

    PubMed

  51. High-Flow Nasal Cannula Therapy for Acute Respiratory Failure in Patients with Interstitial Pneumonia: A Retrospective Observational Study

    Omote N., Hashimoto N., Matsuda N., Nishida K., Sakamoto K., Ando A., Nakahara Y., Nishikimi M., Higashi M., Matsui S., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 197   page: .   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  52. Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: Novel therapeutic implications and challenges

    Hattori Yuichi, Hattori Kohshi, Suzuki Tokiko, Matsuda Naoyuki

    PHARMACOLOGY & THERAPEUTICS   Vol. 177   page: 56-66   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pharmthera.2017.02.040

    Web of Science

    PubMed

  53. A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS

    Yamamoto Seiji, Muramatsu Masashi, Azuma Erika, Ikutani Masashi, Nagai Yoshinori, Sagara Hiroshi, Koo Bon-Nyeo, Kita Satomi, O'Donnell Erin, Osawa Tsuyoshi, Takahashi Hiroyuki, Takano Ken-ichi, Dohmoto Mitsuko, Sugimori Michiya, Usui Isao, Watanabe Yasuhide, Hatakeyama Noboru, Iwamoto Takahiro, Komuro Issei, Takatsu Kiyoshi, Tobe Kazuyuki, Niida Shumpei, Matsuda Naoyuki, Shibuya Masabumi, Sasahara Masakiyo

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page: 3855   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-03994-1

    Web of Science

    PubMed

  54. Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: attribution to phosphodiesterase 4 upregulation

    Sakai Mari, Suzuki Tokiko, Tomita Kengo, Yamashita Shigeyuki, Palikhe Sailesh, Hattori Kohshi, Yoshimura Naoki, Matsuda Naoyuki, Hattori Yuichi

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   Vol. 312 ( 6 ) page: H1224-H1237   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpheart.00828.2016

    Web of Science

    PubMed

  55. Plasmapheresis therapy has no triglyceride-lowering effect in patients with hypertriglyceridemic pancreatitis

    Miyamoto Kyohei, Horibe Masayasu, Sanui Masamitsu, Sasaki Mitsuhito, Sugiyama Daisuke, Kato Seiya, Yamashita Takahiro, Goto Takashi, Iwasaki Eisuke, Shirai Kunihiro, Oe Kyoji, Sawano Hirotaka, Oda Takuya, Yasuda Hideto, Ogura Yuki, Hirose Kaoru, Kitamura Katsuya, Chiba Nobutaka, Ozaki Tetsu, Oshima Taku, Yamamoto Tomonori, Nagata Keiji, Mine Tetsuya, Saito Koji, Sekino Motohiro, Furuya Tomoki, Matsuda Naoyuki, Hayakawa Mineji, Kanai Takanori, Mayumi Toshihiko

    INTENSIVE CARE MEDICINE   Vol. 43 ( 6 ) page: 949-951   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00134-017-4722-3

    Web of Science

    PubMed

  56. A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score

    Nishikimi Mitsuaki, Matsuda Naoyuki, Matsui Kota, Takahashi Kunihiko, Ejima Tadashi, Liu Keibun, Ogura Takayuki, Higashi Michiko, Umino Hitoshi, Makishi Go, Numaguchi Atsushi, Matsushima Satoru, Tokuyama Hideki, Nakamura Mitsunobu, Matsui Shigeyuki

    SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE   Vol. 25 ( 1 ) page: 49   2017.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13049-017-0392-y

    Web of Science

    PubMed

  57. Regulation of the Cardiovascular System by Histamine

    Hattori Yuichi, Hattori Kohshi, Matsuda Naoyuki

    HISTAMINE AND HISTAMINE RECEPTORS IN HEALTH AND DISEASE   Vol. 241   page: 239-258   2017

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/164_2016_15

    Web of Science

    PubMed

  58. CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracy

    Nishikimi Mitsuaki, Matsuda Naoyuki, Matsui Kota, Takahashi Kunihiko, Ejima Tadashi, Liu Keibun, Ogura Takayuki, Higashi Michiko, Umino Hitoshi, Makishi Go, Numaguchi Atsushi, Matsushima Satoru, Tokuyama Hideki, Nakamura Mitsunobu, Matsui Shigeyuki

    INTENSIVE CARE MEDICINE   Vol. 42 ( 12 ) page: 2106-2107   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00134-016-4492-3

    Web of Science

    PubMed

  59. Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis.

    Hattori M, Yamazaki M, Ohashi W, Tanaka S, Hattori K, Todoroki K, Fujimori T, Ohtsu H, Matsuda N, Hattori Y

    Intensive care medicine experimental   Vol. 4 ( 1 ) page: 36   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40635-016-0109-y

    PubMed

  60. In vitro reduction of antibacterial activity of tigecycline against multidrug-resistant Acinetobacter baumannii with host stress hormone norepinephrine

    Inaba Masato, Matsuda Naoyuki, Banno Hirotsugu, Jin Wanchun, Wachino Jun-ichi, Yamada Keiko, Kimura Kouji, Arakawa Yoshichika

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS   Vol. 48 ( 6 ) page: 680-689   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijantimicag.2016.09.022

    Web of Science

    PubMed

  61. The International Activities in Taiwan by the Joint Burn Care Assistance Team of Physicians from Japan Medical Association and Three Medical Societies.

    Matsuda N, Yamada S, Hinoshita T, Sasaki J, Ikeda H, Harunari N, Sakamoto T

    Japan Medical Association journal : JMAJ   Vol. 59 ( 1 ) page: 12-16   2016.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  62. Alert cell strategy in SIRS-induced vasculitis: sepsis and endothelial cells

    Matsuda Naoyuki

    JOURNAL OF INTENSIVE CARE   Vol. 4   page: 21   2016.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40560-016-0147-2

    Web of Science

    PubMed

  63. [Severe infection in critical emergency care].

    Matsuda N, Takatani Y, Higashi T, Inaba M, Ejima T

    Nihon rinsho. Japanese journal of clinical medicine   Vol. 74 ( 2 ) page: 245-51   2016.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  64. Anti-Inflammatory Profile of Levosimendan in Cecal Ligation-Induced Septic Mice and in Lipopolysaccharide-Stimulated Macrophages

    Wang Qiang, Yokoo Hiroki, Takashina Michinori, Sakata Kimimasa, Ohashi Wakana, Abedelzaher Lobna A., Imaizumi Takahiro, Sakamoto Takuya, Hattori Kohshi, Matsuda Naoyuki, Hattori Yuichi

    CRITICAL CARE MEDICINE   Vol. 43 ( 11 ) page: E508-E520   2015.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000001269

    Web of Science

    PubMed

  65. Radial artery cannulation decreases the distal arterial blood flow measured by power Doppler ultrasound

    Numaguchi Atsushi, Adachi Yushi U., Aoki Yoshitaka, Ishii Yasuhiro, Suzuki Katsumi, Obata Yukako, Sato Shigehito, Nishiwaki Kimitoshi, Matsuda Naoyuki

    JOURNAL OF CLINICAL MONITORING AND COMPUTING   Vol. 29 ( 5 ) page: 653-657   2015.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10877-014-9648-5

    Web of Science

    PubMed

  66. New drug discovery for surviving sepsis from multiple organ failure

    Matsuda Naoyuki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 128 ( 3 ) page: S44-S44   2015.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  67. Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes

    Yamamoto Seiji, Niida Shumpei, Azuma Erika, Yanagibashi Tsutomu, Muramatsu Masashi, Huang Ting Ting, Sagara Hiroshi, Higaki Sayuri, Ikutani Masashi, Nagai Yoshinori, Takatsu Kiyoshi, Miyazaki Kenji, Hamashima Takeru, Mori Hisashi, Matsuda Naoyuki, Ishii Yoko, Sasahara Masakiyo

    SCIENTIFIC REPORTS   Vol. 5   page: 8505   2015.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep08505

    Web of Science

    PubMed

  68. Ultrasonography-guided radial artery catheterization and further optimal sequences

    Adachi Yushi U., Numaguchi Atsushi, Matsuda Naoyuki

    JOURNAL OF CLINICAL MONITORING AND COMPUTING   Vol. 29 ( 1 ) page: 201-202   2015.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10877-014-9608-0

    Web of Science

    PubMed

  69. Lingual tonsil hypertrophy diagnosed by post-mortem computed tomography in a difficult airway case

    Hinoshita T., Numaguchi A., Adachi Y. U., Nakahara K., Matsuda N.

    ACTA ANAESTHESIOLOGICA SCANDINAVICA   Vol. 58 ( 9 ) page: 1162-1163   2014.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/aas.12388

    Web of Science

  70. Continuous administration of landiolol reduced QT dispersion in postoperative patients

    Suzuki Katsumi, Numaguchi Atsushi, Adachi Yushi U., Obata Yukako, Hatano Toshiyuki, Ejima Tadashi, Sato Shigehito, Matsuda Naoyuki

    JOURNAL OF CLINICAL ANESTHESIA   Vol. 26 ( 6 ) page: 438-442   2014.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jclinane.2014.01.017

    Web of Science

    PubMed

  71. Ubiquitin is phosphorylated by PINK1 to activate parkin

    Koyano Fumika, Okatsu Kei, Kosako Hidetaka, Tamura Yasushi, Go Etsu, Kimura Mayumi, Kimura Yoko, Tsuchiya Hikaru, Yoshihara Hidehito, Hirokawa Takatsugu, Endo Toshiya, Fon Edward A., Trempe Jean-Francois, Saeki Yasushi, Tanaka Keiji, Matsuda Noriyuki

    NATURE   Vol. 510 ( 7503 ) page: 162-+   2014.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nature13392

    Web of Science

  72. Not only bupivacaine but also propofol is sinking in lipid?

    Adachi Yushi U., Numaguchi Atsushi, Matsuda Naoyuki

    JOURNAL OF ANESTHESIA   Vol. 28 ( 3 ) page: 476-476   2014.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00540-013-1725-2

    Web of Science

    PubMed

  73. Alert Cell Strategy: Mechanisms of Inflammatory Response and Organ Protection. Reviewed

    Noboru Hatakeyama, Naoyuki Matsuda

    Curr Pharm Des   Vol. 20   page: 5766-5778   2014.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  74. Alert cell strategy: mechanisms of inflammatory response and organ protection.

    Hatakeyama N, Matsuda N

    Current pharmaceutical design   Vol. 20 ( 36 ) page: 5766-78   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  75. The Japanese guidelines for the management of sepsis.

    Oda S, Aibiki M, Ikeda T, Imaizumi H, Endo S, Ochiai R, Kotani J, Shime N, Nishida O, Noguchi T, Matsuda N, Hirasawa H, Sepsis Registry Committee of The Japanese Society of Intensive Care Medicine.

    Journal of intensive care   Vol. 2 ( 1 ) page: 55   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40560-014-0055-2

    PubMed

  76. Landiolol reduces hemodynamic responses to bronchoscopy-assisted suctioning in intubated ICU patients.

    Tochikubo J, Adachi YU, Ejima T, Numaguchi A, Matsuda N, Sato S, Shiiya N

    Journal of intensive care   Vol. 2 ( 1 ) page: 6   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/2052-0492-2-6

    PubMed

  77. Alert Cell Strategy: Mechanisms of Inflammatory Response and Organ Protection

    Hatakeyama Noboru, Matsuda Naoyuki

    CURRENT PHARMACEUTICAL DESIGN   Vol. 20 ( 36 ) page: 5766-5778   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  78. The advanced radial artery cannulation using Insyte-A (TM) with real-time ultrasound guidance

    Adachi Yushi U., Hatano Toshiyuki, Hashimoto Shinsuke, Ejima Tadashi, Murase Kichiro, Matsuda Naoyuki

    JOURNAL OF CLINICAL MONITORING AND COMPUTING   Vol. 27 ( 6 ) page: 703-704   2013.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10877-013-9482-1

    Web of Science

    PubMed

  79. BUNDLE-BASED MANAGEMENT OF SEPTIC SHOCK IN NAGOYA UNIVERSITY EMERGENCY AND MEDICAL ICU

    Matsuda N., Matsushima S., Hashimoto S., Ejima M., Takatani Y., Higashi M., Inaba M., Ohbayashi M., Asada K., Umino J., Hinoshita T., Numaguchi A., Kado M., Adachi Y., Takahashi H.

    INTENSIVE CARE MEDICINE   Vol. 39   page: S480-S480   2013.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  80. INFLAMMATION-INDUCED AUTOPHAGY HUMAN VASCULAR ENDOTHELIAL CELLS

    Matsuda N., Konishi Y., Itoh R., Tochikubo J., Adachi Y.

    INTENSIVE CARE MEDICINE   Vol. 39   page: S239-S240   2013.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  81. The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons

    Koyano Fumika, Okatsu Kei, Ishigaki Shinsuke, Fujioka Yusuke, Kimura Mayumi, Sobue Gen, Tanaka Keiji, Matsuda Noriyuki

    GENES TO CELLS   Vol. 18 ( 8 ) page: 672-681   2013.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12066

    Web of Science

  82. Recurarization after sugammadex following a prolonged rocuronium infusion for induced hypothermia

    Murata Tetsuya, Kubodera Toshi, Ohbayashi Masakazu, Murase Kichiro, Adachi Yushi U., Matsuda Naoyuki

    CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE   Vol. 60 ( 5 ) page: 508-509   2013.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12630-013-9909-7

    Web of Science

    PubMed

  83. Intravenous droperidol decreases the bispectral index during general anesthesia with sevoflurane and remifentanil.

    Adachi YU, Tanaka K, Suzuki S, Nishiwaki K, Matsuda N

    Masui. The Japanese journal of anesthesiology   Vol. 62 ( 1 ) page: 71-4   2013.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  84. Subcutaneous emphysema and ultrasound sonography.

    Kubodera T, Adachi YU, Hatano T, Ejima T, Numaguchi A, Matsuda N

    Journal of intensive care   Vol. 1 ( 1 ) page: 8   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/2052-0492-1-8

    PubMed

  85. The effect of aging on dopamine release and metabolism during sevoflurane anesthesia in rat striatum: An in vivo microdialysis study

    Kimura-Kuroiwa Kaori, Adachi Yushi U., Mimuro Soichiro, Obata Yukako, Kawamata Mikito, Sato Shigehito, Matsuda Naoyuki

    BRAIN RESEARCH BULLETIN   Vol. 89 ( 5-6 ) page: 223-230   2012.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.brainresbull.2012.08.006

    Web of Science

    PubMed

  86. NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte apoptosis.

    Matsuno K, Iwata K, Matsumoto M, Katsuyama M, Cui W, Murata A, Nakamura H, Ibi M, Ikami K, Zhang J, Matoba S, Jin D, Takai S, Matsubara H, Matsuda N, Yabe-Nishimura C

    Free radical biology & medicine   Vol. 53 ( 9 ) page: 1718-28   2012.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.freeradbiomed.2012.08.590

    PubMed

  87. [ECG changes after the induction of general anesthesia with remifentanil: a report of three case].

    Tanaka K, Adachi Y, Suzuki S, Nishiwaki K, Matsuda N

    Masui. The Japanese journal of anesthesiology   Vol. 61 ( 10 ) page: 1128-32   2012.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  88. TAK-1 SIRNA NORMALIZES AUTOPHAGY AND APOPTOSIS IN SEPTIC MOUSE LUNG

    Matsuda N., Tochikubo J., Tamura T., Tsuzuki M., Murase K., Adachi Y.

    INTENSIVE CARE MEDICINE   Vol. 38   page: S18-S18   2012.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  89. MODULATION OF EXPRESSION AND FUNCTION OF ION CHANNELS IN ATRIAL MYOCYTE FROM SEPTIC GUINEA PIG

    Hatakeyama N., Aoki Y., Sakakibara K., Matsuda N., Kinoshita H., Fujiwara Y.

    INTENSIVE CARE MEDICINE   Vol. 38   page: S103-S103   2012.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  90. Epidural catheter insertion during general anesthesia

    Adachi Yushi U., Matsuda Naoyuki

    JOURNAL OF ANESTHESIA   Vol. 26 ( 4 ) page: 633-633   2012.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00540-012-1382-x

    Web of Science

    PubMed

  91. Is it constantly possible to penetrate only the anterior vessel wall against hydrostatic strain?

    Adachi Yushi U., Tuzuki Michitaka, Matsuda Naoyuki

    CRITICAL CARE MEDICINE   Vol. 40 ( 8 ) page: 2534-2535   2012.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0b013e31825453ff

    Web of Science

    PubMed

  92. Is it fluid or air causing anesthesia mumps?

    Adachi Yushi U., Matsuda Naoyuki

    JOURNAL OF ANESTHESIA   Vol. 26 ( 4 ) page: 638-639   2012.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00540-012-1387-5

    Web of Science

    PubMed

  93. Evaluating patient self-assessment of health as a predictor of hospital admission in emergency practice: a diagnostic validity study

    Miyamichi Ryosuke, Mayumi Toshihiko, Asaoka Mineo, Matsuda Naoyuki

    EMERGENCY MEDICINE JOURNAL   Vol. 29 ( 7 ) page: 570-575   2012.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/emj.2010.105247

    Web of Science

    PubMed

  94. Isoflurane Pretreatment Preserves Adenosin Triphosphate-Sensitive K+ Channel Function in the Human Artery Exposed to Oxidative Stress Caused by High Glucose Levels

    Kinoshita Hiroyuki, Matsuda Naoyuki, Iranami Hiroshi, Ogawa Koji, Hatakeyama Noboru, Azma Toshiharu, Kawahito Shinji, Yamazaki Mitsuaki

    ANESTHESIA AND ANALGESIA   Vol. 115 ( 1 ) page: 54-61   2012.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1213/ANE.0b013e318254270d

    Web of Science

    PubMed

  95. Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice

    Kimura-Kuroiwa Kaori, Adachi Yushi U., Obata Yukako, Kawamata Mikito, Sato Shigehito, Matsuda Naoyuki

    JOURNAL OF ANESTHESIA   Vol. 26 ( 3 ) page: 422-428   2012.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00540-012-1344-3

    Web of Science

    PubMed

  96. Role of ion channels in sepsis-induced atrial tachyarrhythmias in guinea pigs

    Aoki Yuta, Hatakeyama Noboru, Yamamoto Seiji, Kinoshita Hiroyuki, Matsuda Naoyuki, Hattori Yuichi, Yamazaki Mitsuaki

    BRITISH JOURNAL OF PHARMACOLOGY   Vol. 166 ( 1 ) page: 390-400   2012.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1476-5381.2011.01769.x

    Web of Science

    PubMed

  97. Pentobarbital Decreased Nitric Oxide Release in the Rat Striatum but Ketamine Increased the Release Independent of Cholinergic Regulation

    Kimura-Kuroiwa Kaori, Adachi Yushi U., Mimuro Soichiro, Kawamata Mikito, Sato Shigehito, Matsuda Naoyuki

    EXPERIMENTAL ANIMALS   Vol. 61 ( 2 ) page: 165-170   2012.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  98. Cochlear Blood Flow and Speech Perception Ability in Cochlear Implant Users

    Nakashima Tsutomu, Hattori Taku, Sone Michihiko, Asahi Kiyomitsu, Matsuda Naoko, Teranishi Masaaki, Yoshida Tadao, Kato Ken, Sato Eisuke

    OTOLOGY & NEUROTOLOGY   Vol. 33 ( 2 ) page: 165-168   2012.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MAO.0b013e318241c0db

    Web of Science

  99. The effect of insulin may not be so simple.

    Kinoshita H, Matsuda N

    Anesthesiology   Vol. 116 ( 2 ) page: 488; author reply 489-90   2012.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/ALN.0b013e31823fd04d

    PubMed

  100. [Sudden increases and decreases in bispectral index values more than 30 within 1 minute during general anesthesia].

    Toriyama W, Adachi Y, Obata Y, Sato S, Matsuda N

    Masui. The Japanese journal of anesthesiology   Vol. 61 ( 2 ) page: 210-3   2012.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  101. Roles of neuronal nitric oxide synthase, oxidative stress, and propofol in N-methyl-D-aspartate-induced dilatation of cerebral arterioles

    Hama-Tomioka K., Kinoshita H., Nakahata K., Kondo T., Azma T., Kawahito S., Hatakeyama N., Matsuda N.

    BRITISH JOURNAL OF ANAESTHESIA   Vol. 108 ( 1 ) page: 21-29   2012.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/bja/aer368

    Web of Science

  102. ENDOPLASMIC RETICULUM STRESS SENSOR PROTEINS EXPRESSION AND ITS ALTERATION IN SEPSIS DEPEND ON CELL TYPES IN PANCREAS AND ADRENAL GLAND

    Suzuki T., Matsuda N., Teramae H., Sato N., Koike K.

    SHOCK   Vol. 37   page: 111-111   2012

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  103. Pentobarbital decreased nitric oxide release in the rat striatum but ketamine increased the release independent of cholinergic regulation.

    Kimura-Kuroiwa K, Adachi YU, Mimuro S, Kawamata M, Sato S, Matsuda N

    Experimental animals   Vol. 61 ( 2 ) page: 165-70   2012

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1538/expanim.61.165

    PubMed

  104. [Inflammatory alert cell strategy in septic acute lung injury].

    Matsuda N, Tsuzuki M, Ichikawa S, Tochikubo J, Tamura T, Adachi Y

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica   Vol. 138 ( 4 ) page: 151-4   2011.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  105. High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors.

    Kageyama S, Yokoo H, Tomita K, Kageyama-Yahara N, Uchimido R, Matsuda N, Yamamoto S, Hattori Y

    Cardiovascular diabetology   Vol. 10   page: 73   2011.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1475-2840-10-73

    PubMed

  106. Successful recovery from delayed amniotic fluid embolism with prolonged cardiac resuscitation.

    Hosono K, Matsumura N, Matsuda N, Fujiwara H, Sato Y, Konishi I

    The journal of obstetrics and gynaecology research   Vol. 37 ( 8 ) page: 1122-5   2011.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1447-0756.2010.01470.x

    PubMed

  107. Modification of endotracheal intubation using AirwayScope (TM) videolaryngoscope for straight reinforced tubes

    Minonishi T., Kinoshita H., Hirayama M., Hatakeyama N., Matsuda N.

    MINERVA ANESTESIOLOGICA   Vol. 77 ( 8 ) page: 850-851   2011.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  108. LEVELS OF ANTITHROMBIN ACTIVITY AFTER ANTITHROMBIN ADMINISTRATION INDICATE PROGNOSIS OF SEPTIC DIC PATIENTS

    Mayumi T., Suzuki S., Yamamoto T., Ichikawa T., Onodera M., Tsuzuki M., Kin B., Inoue T., Kainuma M., Takahashi H., Matsuda N., Nishiwaki K.

    SHOCK   Vol. 35   page: 13-13   2011.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  109. Successful treatment of acute lung injury with pitavastatin in septic mice: potential role of glucocorticoid receptor expression in alveolar macrophages.

    Takano K, Yamamoto S, Tomita K, Takashina M, Yokoo H, Matsuda N, Takano Y, Hattori Y

    The Journal of pharmacology and experimental therapeutics   Vol. 336 ( 2 ) page: 381-90   2011.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1124/jpet.110.171462

    PubMed

  110. Issues regarding propofol concentrations within the clinical range.

    Kinoshita H, Matsuda N

    Anesthesiology   Vol. 114 ( 1 ) page: 218; author reply 218-9   2011.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/ALN.0b013e3181ff728d

    PubMed

  111. Alert cell strategy for inflammation and cell death in septic ALI/ARDS

    Matsuda Naoyuki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 115   page: 38P-38P   2011

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  112. Origin of the cerebral microvascular pericytes in the neurogenesis period

    Yamamoto Seiji, Muramatsu Masashi, Azuma Erika, Dohmoto Mitsuko, Takano Ken-ichi, Kita Satomi, Iwamoto Takahiro, Komuro Issei, Niida Shumpei, Shibuya Masabumi, Matsuda Naoyuki, Hattori Yuichi

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 115   page: 86P-86P   2011

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  113. FADD SIRNA REDUCES AUTOPHAGY AND APOPTOSIS IN SEPTIC MICE

    Matsuda Naoyuki, Teramae Hiroki

    CRITICAL CARE MEDICINE   Vol. 38 ( 12 ) page: U20-U20   2010.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  114. Insights Into Sepsis Therapeutic Design Based on the Apoptotic Death Pathway

    Hattori Yuichi, Takano Ken-ichi, Teramae Hiroki, Yamamoto Seiji, Yokoo Hiroki, Matsuda Naoyuki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 114 ( 4 ) page: 354-365   2010.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1254/jphs.10R04CR

    Web of Science

  115. MODULATION ON EXPRESSION AND FUNCTION OF CALCIUM AND POTASSIUM CHANNELS IN SEPTIC GUINEA PIG ATRIUM

    Hatakeyama Noboru, Aoki Yuta, Kinoshita Hiroyuki, Matsuda Naoyuki, Yamazaki Mitsuaki

    CRITICAL CARE MEDICINE   Vol. 38 ( 12 ) page: U51-U51   2010.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  116. Endothelial detachment, caused by low-shear stress and resulting in neointima formation in mice

    Tsuzuki M., Matsuda N., Okumura K., Murohara T.

    EUROPEAN HEART JOURNAL   Vol. 31   page: 403-404   2010.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  117. The Modulation of Vascular ATP-Sensitive K+ Channel Function via the Phosphatidylinositol 3-Kinase-Akt Pathway Activated by Phenylephrine

    Haba Masanori, Hatakeyama Noboru, Kinoshita Hiroyuki, Teramae Hiroki, Azma Toshiharu, Hatano Yoshio, Matsuda Naoyuki

    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS   Vol. 334 ( 2 ) page: 673-678   2010.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1124/jpet.110.167775

    Web of Science

    PubMed

  118. Up-regulation of histamine H4 receptors contributes to splenic apoptosis in septic mice: counteraction of the antiapoptotic action of nuclear factor-kappaB.

    Matsuda N, Teramae H, Futatsugi M, Takano K, Yamamoto S, Tomita K, Suzuki T, Yokoo H, Koike K, Hattori Y

    The Journal of pharmacology and experimental therapeutics   Vol. 332 ( 3 ) page: 730-7   2010.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1124/jpet.109.163543

    PubMed

  119. Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells

    Zhang Xiao-Hong, Yokoo Hiroki, Nishioka Hiroshi, Fujii Hajime, Matsuda Naoyuki, Hayashi Toshio, Hattori Yuichi

    BRITISH JOURNAL OF PHARMACOLOGY   Vol. 159 ( 4 ) page: 928-938   2010.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1476-5381.2009.00594.x

    Web of Science

    PubMed

  120. Tracheal intubation with the AirwayScope videolaryngoscope using straight vs curved reinforced tubes.

    Minonishi T, Kinoshita H, Tange K, Hatakeyama N, Matsuda N, Azma T, Hatano Y

    Canadian journal of anaesthesia = Journal canadien d'anesthesie   Vol. 57 ( 1 ) page: 92-3   2010.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12630-009-9210-y

    PubMed

  121. Increased death receptor pathway of apoptotic signaling in septic mouse aorta: effect of systemic delivery of FADD siRNA.

    Matsuda N, Teramae H, Yamamoto S, Takano K, Takano Y, Hattori Y

    American journal of physiology. Heart and circulatory physiology   Vol. 298 ( 1 ) page: H92-101   2010.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpheart.00069.2009

    PubMed

  122. Possible involvement of brain cytokines-modulating signaling pathways in hypothalamus in encephalopathy and development of sepsis in mice

    Imai Satoshi, Narita Minoru, Ishiwata Sayuri, Narita Michiko, Honda Natsuki, Niikura Keiichi, Kuzumaki Naoko, Matsuda Naoyuki, Suzuki Tsutomu

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 112   page: 25P-25P   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  123. Possible involvement of central cytokines and chemokines in the development of sepsis following cecal ligation and puncture in mice

    Ishiwata Sayuri, Narita Minoru, Narita Michiko, Honda Natsuki, Imai Satoshi, Niikura Keiichi, Kuzumaki Naoko, Matsuda Naoyuki, Suzuki Tsutomu

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 112   page: 107P-107P   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  124. Insights into sepsis therapeutic design based on the apoptotic death pathway.

    Hattori Y, Takano K, Teramae H, Yamamoto S, Yokoo H, Matsuda N

    Journal of pharmacological sciences   Vol. 114 ( 4 ) page: 354-65   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

▼display all

Books 3

  1. 救急・集中治療・生体侵襲と臓器管理

    編集・執筆 松田直之( Role: Joint author)

    総合医学社,東京  2008.11 

     More details

    Language:Japanese

  2. Histamine and sepsis. Histamine: Biology and Medical Aspects.

    Matsuda N,Hattori Y,Gando S.( Role: Joint author)

    Karger Spring Med Publishing Ltd.  2004.5 

     More details

    Language:English

  3. Pathological significance of over-production of histamine and altered transcriptional regulation of H1- and H2-receptors during septic shock.

    Matsuda N,Hattori Y,Kemmotsu O,Gando S.( Role: Joint author)

    Elsevier Science  2001.3 

     More details

    Language:English

KAKENHI (Grants-in-Aid for Scientific Research) 15

  1. 敗血症性多臓器不全におけるSTAT3の遺伝子治療による創薬科学医療イノベーション

    2019.4

    科学研究費補助金  基盤研究(B)

      More details

    Authorship:Principal investigator 

    【概 要】インターロイキン6(IL-6:Interleukin-6)は,救急・集中治療領域などの急性期管理で,炎症に随伴して上昇する血清マーカーである。本研究は,様々な細胞におけるIL-6受容体シグナルについて,「敗血症動物モデル」および「ヒト培養細胞」の2つの研究系で解析する。以下の4つの内容を主目的として,IL-6受容体シグナルを解析する。
     ①  敗血症病態で血中濃度の上昇するIL-6が,「どの細胞に作用し」,「どのような作用をもたらすか」を,IL-6受容体シグナルを持つ「細胞同定」として明らかとする。
     ② IL-6受容体シグナルで活性化される主要な転写因子であるSignal Transducers and Activator of Transcription-3(STAT-3)を,各種の臓器系細胞や血球系細胞において「どの強度まで活性化できるか」を比較解析し,IL-6受容体発現細胞における「STAT-3活性強度」を評価する。
     ③ IL-6受容体シグナルとして活性化される「転写因子STAT-3」の結合する転写領域GAS(γ-interferon-activated site;5’-TTTCCnGGAAA-3’,n:任意)およびSIE(c-sis-inducible element; 5’-GATCTACGGATTTCCGGGAAATGAAGCT-3’)の活性を,「デコイ核酸などの遺伝子治療」で抑制し,様々な細胞のSTAT-3の役割を明確とする。
     ④ 慢性関節リウマチへの適応がある「抗IL-6α抗体」である「サリルマブ」や「トシリズマブ」の敗血症病態における効果を転写因子活性の「遺子治療」と比較する。

  2. Molecular basis of sex differences in sepsis-induced multi-organ dysfunction syndrome

    Grant number:21H03035  2021.4 - 2025.3

      More details

    Authorship:Coinvestigator(s) 

  3. Treatment strategy against sepsis induced thrombocytopenia and the associated complement hyperactivation

    Grant number:21K09065  2021.4 - 2024.3

      More details

    Authorship:Coinvestigator(s) 

  4. 敗血症病態における心筋細胞内Ca2+動態の解析

    2017.4 - 2019.3

    科学研究費補助金  基盤研究(C)

      More details

    Authorship:Coinvestigator(s) 

  5. Drug discovery for improvement of positive inotropic effect in septic myocardial injury

    2015.4 - 2017.4

    Grant-in-Aid for Scientific Research 

      More details

    Authorship:Principal investigator 

  6. Drug discovery platform for improvement of positive inotropic effect in septic myocardium

    Grant number:15K15661  2015.4 - 2017.3

    Matsuda Naoyuki

      More details

    Authorship:Principal investigator 

    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

    We weighed the effects of dobutamine and milrinone as inotropes in BALB/c mice with cecal ligation and puncture (CLP)-induced sepsis. Surface expression levels of β1-adrenoceptors and alpha subunits of three main G protein families in myocardium were unaffected by CLP-induced sepsis. Plasma cyclic adenosine monophosphate (cAMP) levels were significantly elevated in both sham-operated and CLP mice in response to milrinone but only in sham-operated controls in response to dobutamine. Of phosphodiesterase (PDE) isoforms, PDE4D, but not PDE3A, both of which are responsible for cardiac cAMP hydrolysis, was significantly upregulated in CLP mouse myocardium. We define a novel mechanism for the impaired responsiveness to dobutamine as an inotrope in sepsis and understanding the role of PDE4D in modulating cardiac functional responsiveness in sepsis may open the potential of PDE4D-targeted therapeutic option in septic patients with low cardiac output who have a need for inotropic support.

  7. 敗血症性多臓器不全における主要臓器再生への遺伝子治療とiPS細胞の応用

    2013.4 - 2017.3

    科学研究費補助金  基盤研究(B)

      More details

    Authorship:Principal investigator 

  8. 敗血症病態に合併するタンパク異化病態の分子生化学的解明と遺伝子治療の開発

    2010.4 - 2012.3

    科学研究費補助金  基盤研究(A)

    松田直之

      More details

    Authorship:Principal investigator 

  9. Role of Autophagy and the Molecule Targeting in Sepsis

    Grant number:22249059  2010 - 2012

    MATSUDA Naoyuki

      More details

    Authorship:Principal investigator 

    Grant amount:\48750000 ( Direct Cost: \37500000 、 Indirect Cost:\11250000 )

    Sepsis, known as a inducer of severe multiple organ diseases, has no established effective treatment except for antibiotics. Sepsis can lead multiple organ failure due to amid acid transformation to acute phase proteins such as inflammatory cytokines. In this study, I have found that some parts of autophagy-related gene family wereincreased at transcriptional and translated levels in the acute terms of sepsis of cultured human vascular endothelial cells and sepsis mouse models. LC3 was activated in particular, and promoted an autophagosome formation. It was concluded that FADD, TAK-1 andtranscriptional activity of NF-κB and AP-1 were significantly related with autophagy acceleration in the cultured human vascular endothelial cells and sepsis mouse model.

  10. Bio-Marker of Severe Sepsis in Super-Senior Citizens

    2009.9 - 2010.3

    Grant-in-Aid for Scientific Research 

      More details

    Authorship:Coinvestigator(s) 

  11. Detection of Circulating Endothelial Cells in Severe Sepsis

    Grant number:21390482  2009 - 2011

    KOIKE Kaoru

      More details

    Authorship:Coinvestigator(s) 

    Sepsis is a severe disorder as systemic inflammation with infection. In this illness, vascular endothelial damage proceeds to induce disseminated intravascular coagulation(DIC). This study revealed that circulating endothelial cell(CEC) was increased and plasma platelet count was decreased in the time dependent manner after sepsis induction by cecal ligation and puncture in male BALB-C mice. Nuclear factor-kappaB decoy oligonucleotides more strongly decreased CEC count than inactivation of FADD, TAK-1, and activator protein-1. The CEC count could be a reliable marker to evaluate DIC and dysfunction of vascular endothelium.

  12. Role of Bone Marrow Derived Stem Cells for Repair of Multiple Organs in Severe Sepsis

    2008.4 - 2010.3

    Grant-in-Aid for Scientific Research 

      More details

    Authorship:Principal investigator 

  13. The transcription factor AP-1 as a molecular target in sepsis therapy

    Grant number:20590250  2008 - 2010

    HATTORI Yuichi

      More details

    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    Polymicrobial sepsis was induced by cecal ligation and puncture (CLP) in BALB/c mice (8-12 wk of age). The DNA binding activity of AP-1, as assessed by electrophoretic mobility shift assay, was time-dependently increased in lung tissues from mice after the onset of CLP-induced sepsis. This increase was effectively eliminated by in vivo transfection of AP-1 decoy oligonucleotides (ODNs). Sepsis induction significantly increased surface expression of death receptors, such as TNF-R1, Fas, DR4, and DR5, in lung and aortic tissues after sepsis. Furthermore, the gene and protein levels of FADD, which recruits procaspase-8 into the death-inducing signaling complex, were increased after sepsis induction. These sepsis-induced changes were eliminated by systemic application of AP-1 decoy ODNs. TUNEL assays revealed that the significant appearance of cell apoptosis in lung and aortic tissue sections from septic mice was prevented by systemic treatment with AP-1 decoy ODNs. When endotoxic shock was induced by an intravenous injection of 10mg/kg lipopolysaccharide (LPS) in mice, expression levels of inflammatory molecules, including IL-1R, IL-6R, HMGB-1, and gp130, were highly increased, which was significantly inhibited by AP-1 decoy ODN treatment. All animals which received LPS died within 48h, and the animals that were treated with AP-1 decoy ODNs after LPS exhibited a striking improvement of survival. Our results suggest that AP-1 decoy ODN therapy represent an effective strategy in the treatment of sepsis. In addition, systemic administration of siRNA targeting FADD, which was found to be transactivated by AP-1, prevented the development of acute lung injury in CLP mice, and improved their survival. These findings indicate the potential usefulness of FADD siRNA for gene therapy of the septic syndrome.

  14. Gene Therapy of Severe Sepsis

    2007.4 - 2010.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(B)

      More details

    Authorship:Principal investigator 

  15. Analysis of cerebral microcirculatory regulation in relation to anesthetics and gene therapy using the live-cell imaging

    Grant number:19390409  2007 - 2010

    KINOSHITA Hiroyuki

      More details

    Authorship:Coinvestigator(s) 

    We employed the computer-assisted microscopy to evaluate microvascular function in the rat brain slices. Electrical stimulation induced constriction of the cerebral parenchymal arteriole, whereas an inhibitor of 20-HETE abolished this response. NMDA, which is one of excitatory amino acids, produced dilation of these arterioles, corresponding with intracellular production of superoxide in addition to nitric oxide in the smooth muscle cells. Propofol within clinically relevant concentrations reduced these vascular responses.

▼display all

 

Teaching Experience (On-campus) 16

  1. Emergency Medicine

    2021

  2. Emergency Medicine

    2020

  3. 救急医学

    2019

     詳細を見る

    大講堂講義内容
     本講では、総論として「救急医学」と「集中治療医学」の学術背景を解説し、各講義の中で救急患者の診断と治療、集中治療の診断と治療の考える根底を作ることを目的としています。講義数が9コマであり、救急医学と集中治療の学習の基盤を形成するための系統講義としています。

    臨床実習内容
     臨床実習では、救急科専門医および集中治療専門医により、実践的テーマを設定した講義と演習、そして患者さんを受け持つことによる実習が行われます。臨床実習は、医学部附属病院での診療に即した実習です。救急搬入の実際、急性期ベッドサイドでの診察などを通じて、急性期医療の診断と治療を学び、急性期管理医学の根底を整理して頂いています。院内外の実習を直接担当し、実習の最終日のまとめも担当させていただいています。また、臨床実習Ⅱでは、将来、救急医学に進みたいと考える希望者が、他病院での救急実習を含めて、より深く急性期医療を学ぶことができる内容とします。

  4. ALI/ARDSの病態と治療

    2010

     詳細を見る

    2010年より毎年継続

  5. ショックの病態と治療

    2010

     詳細を見る

    ショックの病態と治療

  6. 急性腎不全の管理

    2010

     詳細を見る

    2010年より毎年継続

  7. 急性期抗菌薬の適正使用

    2010

     詳細を見る

    2010年より毎年継続

  8. 急性期栄養管理の学術とポイント

    2010

     詳細を見る

    2010年より毎年継続

  9. 敗血症の病態生理学的研究と創薬

    2010

     詳細を見る

    2010年より毎年継続

  10. 人工呼吸器のモニタリング

    2010

     詳細を見る

    2010年より臨床実習中の講義および医師教育として通年の施行としている。年50回程度。

  11. 教養科目 生命科学と現代医療

    2021

     詳細を見る

    救急医療と集中治療に関する全学教養としての解説講義

  12. 特別講義 急性期多臓器不全の全身管理と研究

    2021

     詳細を見る

    集中治療医学に関する特別講義

    講義内容

    (1)総論:多臓器不全の病態学   救急・集中治療医学分野 教授 松田直之

     多臓器不全が進行する過程として,臓器を構成する上皮系細胞や血管内皮細胞の炎症を感知する細胞内情報伝達を考察する。脳,脊椎,筋骨格系,肺,心臓,血管,肝臓,腎臓,末梢神経,血液細胞の相互連関を解説する。今後の創薬研究の方向性について,広く討議する。
    Key word: damage-associated molecular patterns(DAMPs),pathogen-associated molecular patterns(PAMPs),Toll-like受容体,nucleotide-binding oligomerization domain(NOD), NOD-like receptors (NLRs),AIM2-like receptors(ALRs),retinoic acid-inducible gene-Ⅰ(RIG-Ⅰ)like receptors(RLRs),C型レクチン受容体,交感神経緊張,細胞内Ca2+過負荷,ミトコンドリア死,など

    (2)急性肺傷害の診断と治療    救急・集中治療医学分野 教授 松田直之

     急性肺傷害は,医師になれば必ず誰もが自身の担当している患者さんで遭遇する病態である。急性肺傷害に対しては,その原因となるDAMPsシグナルの主因の評価が大切であり,この緩和が治療の鍵となる。現在の急性肺傷害の定義,そして急性肺傷害の病態と治療を解説し,呼吸機能回復のための今後の研究を含めた討議とする。
    Key word: ARDS,ARDS Berlin定義,PaO2/FIO2,転写因子,Deathシグナル,Ⅱ型肺胞上皮細胞,骨髄由来多能性分化細胞,繊維芽細胞の細胞内情報伝達シグナル,血管透過性亢進,少量ステロイド療法,人工呼吸器の適正使用,PEEP,high flow nasal cannula,NPPVなど。

    (3)ショックの診断と治療      救急・集中治療医学分野 教授 松田直之

     ショックは急性循環不全と同義である。このショックの定義,ショックを呈する4つ病態,さらにショックがもたらす虚血と細胞死について解説し,各ショック分類に適した治療,播種性血管内凝固症候群を合併した際の病態と管理の方向性について解説する。
    Key word: 血流分布異常性ショック,循環血液量減少性ショック,心原性ショック,拘束性ショック,early goal-directed therapy,warm shock,cold shock, 細胞内Ca2+過負荷,網状皮斑(livedo),播種性血管内凝固症候群(DIC),など。

    (4)急性腎傷害の診断と治療   救急・集中治療医学分野 教授 松田直之

     腎臓の解剖学と生理学を復習し,その上で急性腎傷害の定義,急性腎傷害の病態学的解釈と治療を解説する。その上で,血液浄化法を用いる場合についての指針,透析療法と濾過療法の区分,吸着療法の3つのエッセンスをまとめる。腎機能回復のための今後の研究を含めた討議とする。
    Key word: KIDGOガイドライン,RIFLE criteria,AKIN criteria,クレアチニン,BUN,クレアチニン-クリアランス,ネフロン,たこ足細胞,メサンギウム細胞,持続血液濾過透析,CRRT,限外濾過,吸着,クリアランス,など。

    (5)急性期における消化管および栄養の管理  救急・集中治療医学分野 教授 松田直之
     消化管および肝胆膵の解剖と生理学および消化管ホルモンの作用を復習し,他の臓器傷害との関連性を論じる。また,急性期の栄養管理について,今後の研究を含めた討議とする。
    Key word: 消化管出血,輪状筋,縦走筋,消化管免疫,消化管内のpH管理,カルシウム感受性,急性肝不全,伊東細胞,急性膵炎ガイドライン,TOKYOガイドライン,急性期栄養管理,など。

  13. 救急医学

    2021

     詳細を見る

    講義内容

    (1)総論 救急・集中治療医学    救急・集中治療医学分野  教授 松田直之 
       救急医学と集中治療医学の対象とする緊急性と重症性の高い病態について、病態生理学的観点から診断と治療の概念を総括します。この講義の聴講により、救急医学のテキストを読みやすいものとします。本講では、さらに急性期管理医学としての管理システム構築方法や救急医療法制を解説し、救急医療を国における方向性と立ち位置、今後の形体や方策を論じます。重症感染症、多発外傷、広範囲熱傷、気道熱傷、肺挫傷、心肺停止などの実例を紹介し、救急医学と集中治療医学の概要を解説します。
      理解すべき内容とキイ・ワード:救急科専門医制度、救急医療システム、内因性疾患の急性増悪、交通外傷、広範囲熱傷、ヘリ搬送、ショック、救命、心肺停止、全身性炎症反応、交感神経症候群、サイトカインストーム、緊急性、重症度。

    (2)多臓器不全の病態と管理     救急・集中治療医学分野  教授 松田直之
       救急医学は、critical careおよびintensive careとして急性期病態を救命救急センターや集中治療室で管理する。この病態は、多臓器不全であり、生体侵襲に対して急性期の生体反応として生じる統一性が認められる。このような急性相反応、自律神経活性、全身性炎症と多臓器不全の関連について解説する。
      理解すべき内容とキイ・ワード:多臓器不全症候群、敗血症、全身性炎症案脳症候群、ARDS、肺線維症、ショック、AKI、急性脊髄傷害、急性消化管症候群、オートファジー、アポトーシス、炎症性サイトカイン、カテコラミン受容体シグナル、急性期再生医療。

    (3)心肺蘇生の管理エッセンス      救急・集中治療医学分野  教授 松田直之
       心肺停止の評価方法、2015年に改定された心肺蘇生ガイドラインに準じた心肺蘇生法、2015年までの心肺蘇生法などを解説します。既に実習では、basic life support(BLS)を習得していると思います。現在の心肺蘇生管理の仕組みを解説すします。この内容の理論的解釈に加えて、advanced life support(ACLS)の要点を整理し、心肺蘇生の重要内容を説明できることを目標とします。
      理解すべき内容とキイ・ワード:来院時心肺停止、CPAPA、気道確保、心臓マッサージ、BLS、ACLS、AED、交感神経症候群、接触感染予防、ARDS、AKI、蘇生後低酸素性脳症、低体温療法、脳蘇生。

    (4)多発外傷の診断と治療    救急・集中治療医学分野  教授 松田直之
       外傷診療は、救急医学における重要な診療内容の一つです。特に、全身管理を必要とする多発外傷の特徴、外傷患者の初期診療における標準化された診療内容、および「システム化」と「仕組み化」における知識を整理します。講義は、実際の多発外傷の症例提示を含めて、視覚的に、かつ管理における最先端内容を提示し、教科書を読みやすいものとします。
      理解すべき内容とキイ・ワード:JATEC、JPTEC、PAD、ABCDEアプローチ、ダブルアイ、primary survey、secondary survey、tertiary survey、病院前救護体制、AMPLE、FAST、PATBED2X、FIXES。

    (5)熱傷の管理と治療          救急・集中治療医学分野  教授 松田直之   熱傷の定義、深度分類、熱傷範囲の診断、重症度評価としてburn indexの求め方、輸液法、創処置と治療、再生医療の導入について解説します。その上で、広範囲熱傷における炎症管理としての集中治療について解説します。
      理解すべき内容とキイ・ワード:深達度、Ⅰ度熱傷、Ⅱ度熱傷、Ⅲ度熱傷、burn index、気道熱傷、シアン中毒、一酸化炭素中毒、皮膚移植。

    (6)急性薬物中毒の診断と治療    救急・集中治療医学分野  教授 松田直之
       急性薬物中毒は、救急疾患として頻回に認められる病態です。呼吸、循環、代謝を含めた適切な初期診療が必要となります。急性薬物中毒の一般的な診断と治療について解説し、薬理作用の復習とする一方で、全身管理の基本を整理します。特に臨床に用いられる薬物の中毒物質の種類、胃洗浄の具体的な方法、応急処置、および治療について解説します。
      理解すべき内容とキイ・ワード:気道確保、管制支障、胃洗浄、活性炭、血液浄化法、誤嚥性肺炎。

    (7)災害医療・減災医療システム   救急・集中治療医学分野  教授 松田直之
       南海地震、東南海連動地震が迫っていると言われていますが、このような震災が起きた際に、病院でどのような初動が行われるかを解説します。その一方で、バイオテロ、核対策も不可欠な時代となっています。阪神淡路大震災、東日本大震災、大規模犯罪、テロなどの実例を提示しながら、現在の災害医療システムについて概説し、救急医療、集中治療、ヘリコプターによる広域搬送システム、在宅医療との密接な関連として、救急医療の平素からの活動性の重要性を学術として解説します。講義内容としては、トリアージ方法、広域搬送の方法について、さらに疾病としては多発外傷、Crush症候群、一酸化炭素中毒、熱傷、溺水などとの関連について解説します。
      理解すべき内容とキイ・ワード:自然災害、人為的災害、救急医療、DMAT、JMAT、CSCATTT、METHANE、多発外傷診療、PTD、STARTトリアージ、PATトリアージ、広域搬送。

    (8)救急初期診療ER:診断と治療(1)  救急・集中治療医学分野  教授 松田直之
    (9)救急初期診療ER:診断と治療(2)  救急・集中治療医学分野  教授 松田直之
       救急外来を徒歩で来院する患者さんの主訴に対して、緊急性の高い鑑別診断として考えなければならない内容について、鑑別診断のアセスメントと治療を解説します。この代表的な主訴として、意識障害、発熱、胸痛、腹痛について、バイタルサインの時系列での評価方法を提示し、詳細な評価方法を解説します。一方、ER(Emergency Room)では、迅速診断に加えて、緊急性を形成する病態解釈と治療が不可欠です。臨床実習に先立った基礎形成期として、急性肺傷害、ショック、急性腎傷害、重症感染症、環境異常症について解説します。
      理解すべき内容とキイ・ワード:鑑別診断、緊急性、重症性,アセスメント、治療指針。

  14. 現代医療と生命科学

    2021

     詳細を見る

    救急医療と集中治療についての講義

  15. 現代医療と生命科学

    2019

     詳細を見る

    全学教養授業として,90分2コマ,180分の講義を担当した。

  16. Life Sciences and Modern Medicine

    2011

▼display all

Teaching Experience (Off-campus) 11

  1. Emnergency Medicine

    2021.4 - 2022.3 Aichi Mizuho College)

     More details

    Level:Undergraduate (specialized)  Country:Japan

  2. 麻酔・蘇生学「敗血症/SIRS研究の基礎と臨床」

    2009.4 - 2010.3 東北大学医学部)

  3. 救急医学「急性薬物中毒の診断と治療」

    2009.4 - 2010.3 京都府立医科大学)

  4. 臨床薬理学「救急医療と薬理学」

    2009.4 - 2010.3 京都府立医科大学)

  5. 循環管理・ショック

    2009.4 - 2010.3 徳島大学医学部)

  6. 麻酔科学「呼吸管理」

    2009.4 - 2010.3 富山大学医学部)

  7. 呼吸器内科「急性肺障害の診断と治療」

    2009.4 - 2010.3 富山大学医学部)

  8. 臨床薬理学「救急・集中治療におけるEBMの実践」

    2009.4 - 2010.3 富山大学医学部)

  9. 早期体験学習「救急・集中治療」

    2009.4 - 2010.3 星薬科大学)

  10. 大学院特別講義

    2019.4 - 2020.3 University of Shizuoka)

  11. 大学院特別講義

    2019.4 - 2020.3 University of Toyama)

▼display all

 

Social Contribution 4

  1. World Sepsis Day in Nagoya and Tokai, Japan

    Role(s):Appearance, Panelist, Commentator, Presenter, Media coverage, Lecturer, Advisor, Informant, Organizing member, Demonstrator, Contribution

    Naoyuki Matsuda project  Interviews, Article postings, CBC Radio, etc.  2012.9

     More details

    Audience: Schoolchildren, Junior students, High school students, College students, Graduate students, Teachers, Guardians, Researchesrs, General, Scientific, Company, Civic organization, Media

    Type:TV or radio program

  2. World Sepsis Day/ Global Sepsis Alliance

    Role(s):Appearance, Commentator, Lecturer, Contribution

  3. Sepsis Festival 2019 in NAGOYA

    Role(s):Panelist, Commentator, Presenter, Media coverage, Interviewer, Editer, Lecturer, Informant, Planner, Organizing member, Demonstrator, Contribution

    Naoyuki Matsuda MD, PhD  2019.3 - 2019.4

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students, College students, Graduate students, Teachers, Guardians, Researchesrs, General, Scientific, Company, Civic organization, Governmental agency, Media

    Type:Science festival

  4. Global Sepsis Alliance 世界敗血症デイ運営 in NAGOYA

    2011.9

     More details

    敗血症の診療成績を高めるために,Global Sepsis Allianceに所属し,東海地方にGlobal Sepsis Alliance in NAGOYAを設立しました。年1回9月13日を世界敗血症デイとし,世界と連携して東海および日本の敗血症診療キャンペーンを実施しています。「Global Sepsis Alliance in NAGOYA」の代表として,感染症診療の適正化に向けた国際連携を展開しています。

Media Coverage 3

  1. 世界と連携した集中治療教育 TV or radio program

    松田直之  2007.1

     More details

    集中治療の教育活動を,講演,メディア,誌上掲載などの方策として,世界と連携して行っています。

  2. 救急医療を知るための会 TV or radio program

    松田直之  2005.4

     More details

    救急医療のすべてについて,仕組み作り,重要な管理内容,救急医療の詳細等について,講演,実演,アドバイスなどを,日本救急医学会指導医・専門医として広く行っています。

  3. 敗血症という病態を知っていただくための会

    1998.4

     More details

    敗血症について,医療従事者のみではなく,広く市民の皆さまに情報提供しています。

Academic Activities 2

  1. 救急医療に関する報道協力 International contribution

    Role(s):Planning, management, etc., Panel moderator, session chair, etc., Supervision (editorial), Review, evaluation, Planning/Implementing academic research, Peer review

    テレビ局・ラジオ局  2000.4

     More details

    Type:Scientific advice/Review 

    救急医療のかかえる現在の課題,そして将来の展望について,さまざまなインタビューに協力し,本邦および世界の救急医療の発展に貢献する方針としています。

  2. Press cooperation on the management of various types of infectious diseases and sepsis

    Role(s):Planning, management, etc., Panel moderator, session chair, etc., Supervision (editorial), Review, evaluation, Planning/Implementing academic research, Peer review

    2010.2

     More details

    Type:Scientific advice/Review 

    Many understandings about the management of infectious diseases and sepsis will be provided to contribute Japan and the world.