Faculty Profiles - HOSHIYAMA, Minoru

West症候群におけるてんかんネットワークの継時的変化

星野高志, 小口和代, 井上健二, 寳珠山稔

理学療法学Supplement Vol. 47S1 ( 0 ) page： F-83_2 - F-83_2 2020

多感覚継続刺激下における視聴覚同時変化に対する脳磁場反応

田中絵実, 木田哲夫, 柿木隆介, 寳珠山稔

日本生体磁気学会誌 Vol. 33 ( 1 ) page： 135 - 137 2020

A magnetoencephalographic study of longitudinal brain function alterations following carpal tunnel release. International journal Open Access

Katsuyuki Iwatsuki, Minoru Hoshiyama, Akihito Yoshida, Takaaki Shinohara, Hitoshi Hirata

Scientific reports Vol. 9 ( 1 ) page： 19776 - 19776 2019.12

Language：English Publishing type：Research paper (scientific journal)

We investigate changes in brain function before and after carpal tunnel release. Magnetoencephalography (MEG), during which we recorded somatosensory evoked cortical magnetic fields (SEFs), and a clinical evaluation were performed before surgery and 6 months after. The distance on the vertical axis between the equivalent current dipoles (ECDs) for the first and third digits before surgery was significantly less than after surgery. There were no significant differences in values between the control participant and patients after surgery. In terms of distal motor latency, there was a negative correlation with the distance. The recovery function of the root mean square (RMS) before surgery for the N20m was less suppressed at 10 ms of ISI in patients, compared to controls. There were no significant differences in the RMS values for patients before and after surgery. Our results indicate that treating peripheral nerve lesions, such as in carpal tunnel release, positively modifies brain function.

DOI： 10.1038/s41598-019-56190-8

牧祐輝, 伊藤祐史, 岡井佑, 白木杏奈, 川口将宏, 鈴木健史, 田中雅大, 坂口陽子, 山本啓之, 中田智彦, 城所博之, 前澤聡, バガリナオ・エピファニオ, 寶珠山稔, 夏目淳

臨床神経生理学 Vol. 47 ( 5 ) page： 432 - 432 2019.10

Meaningful occupation: A self-awareness intervention for patients with unilateral spatial neglect Reviewed

Kaori KAWABATA and Minoru HOSHIYAMA

New Zealand Journal of Occupational Thearpy page： in press 2019.9

Action performance in children with autism spectrum disorder at preschool age: A pilot study Reviewed

Misako Sano, Kaori Yamaguchi, Reiko Fukatsu, Minoru Hoshiyama

International Journal of Developmental Dissabilities page： in press 2019.9

Action performance in children with autism spectrum disorder at preschool age: A pilot study Reviewed

Misako Sano, Kaori Yamaguchi, Reiko Fukatsu, Minoru Hoshiyama

International Journal of Developmental Dissabilities page： in press 2019.9

Meaningful occupation: A self-awareness intervention for patients with unilateral spatial neglect Reviewed

Kaori KAWABATA, Minoru HOSHIYAMA

New Zealand Journal of Occupational Thearpy page： in press 2019.9

Reorganization of brain networks and its association with general cognitive performance over the adult lifespan. Reviewed International journal Open Access

Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshiaki Taoka, Shuji Koyama, Hiroki C Tanabe, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Norio Ozaki, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Gen Sobue

Scientific reports Vol. 9 ( 1 ) page： 11352 - 11352 2019.8

Language：English Publishing type：Research paper (scientific journal)

Healthy aging is associated with structural and functional changes in the brain even in individuals who are free of neurodegenerative diseases. Using resting state functional magnetic resonance imaging data from a carefully selected cohort of participants, we examined cross sectional changes in the functional organization of several large-scale brain networks over the adult lifespan and its potential association with general cognitive performance. Converging results from multiple analyses at the voxel, node, and network levels showed widespread reorganization of functional brain networks with increasing age. Specifically, the primary processing (visual and sensorimotor) and visuospatial (dorsal attention) networks showed diminished network integrity, while the so-called core neurocognitive (executive control, salience, and default mode) and basal ganglia networks exhibited relatively preserved between-network connections. The visuospatial and precuneus networks also showed significantly more widespread increased connectivity with other networks. Graph analysis suggested that this reorganization progressed towards a more integrated network topology. General cognitive performance, assessed by Addenbrooke's Cognitive Examination-Revised total score, was positively correlated with between-network connectivity among the core neurocognitive and basal ganglia networks and the integrity of the primary processing and visuospatial networks. Mediation analyses further indicated that the observed association between aging and relative decline in cognitive performance could be mediated by changes in relevant functional connectivity measures. Overall, these findings provided further evidence supporting widespread age-related brain network reorganization and its potential association with general cognitive performance during healthy aging.

DOI： 10.1038/s41598-019-47922-x

研究と報告姿勢変換に伴う自律神経活動の変化-若年健常者での検討

星野高志, 小口和代, 寳珠山稔

総合リハビリテーション Vol. 47 ( 5 ) page： 463 - 468 2019.5

脳卒中後の下肢機能の回復とfunctional connectivity 脳波の運動関連領域5電極での検討

星野高志, 小口和代, 寳珠山稔

The Japanese Journal of Rehabilitation Medicine Vol. 56 ( 特別号 ) - 6 2019.5

筋電義手使用者の人工知能回内外制御に対するニューロリハビリテーション的評価

岩月克之, 大山慎太郎, 寶珠山稔, 下田真吾, 栗本秀, 山本美知郎, 建部将広, 平田仁

日本手外科学会雑誌 Vol. 36 ( 1 ) page： O53 - 1 2019.4

Anatomo-electro-clinical correlations of hypermotor seizures with amygdala enlargement: Hippocampal seizure origin identified using stereoelectroencephalography. Open Access

Ishizaki T, Maesawa S, Nakatsubo D, Yamamoto H, Shibata M, Kato S, Yoshida M, Natsume J, Hoshiyama M, Wakabayashi T

Epilepsy & behavior case reports Vol. 11 page： 10 - 13 2019

Magnetoencephalographic evaluation for the myoelectric hand prosthesis with tacit learning system. International journal

Iwatsuki K, Hoshiyama M, Oyama S, Shimoda S, Hirata H

NeuroRehabilitation Vol. 44 ( 1 ) page： 19 - 23 2019

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The effect of tacit learning systems (TLSs) on brain plasticity are as of yet unknown. We developed a myoelectric hand prosthesis equipped with a TLS to auto-regulate forearm rotation in response to upper extremity movement patterns. OBJECTIVE: To evaluate the effects of tacit learning on the central nervous system during a prosthesis control exercise. METHODS: The experienced prosthetic user performed a series of simple mechanical tasks with the TLS inactivated (the baseline condition) and then with it activated (the enhanced, experimental condition). The process was video recorded. Subsequently, the participant viewed video recordings of each condition (baseline and experimental) during magnetoencephalography and electroencephalography recordings. RESULTS: Stronger connections between the motor area and other cortical areas were observed, as indicated by a significant increase in coherence values. CONCLUSIONS: Integration and interoperability may underlie tacit learning and promote motor function-related adaptive neuroplasticity.

DOI： 10.3233/NRE-182514

脳卒中後の運動機能とfunctional connectivityの変化

星野高志, 小口和代, 寳珠山稔

理学療法学Supplement Vol. 46S1 ( 0 ) page： E-63_1 - E-63_1 2019

Language：Japanese Publisher：公益社団法人日本理学療法士協会

【はじめに・目的】 脳活動のネットワークとしての機能が明らかにされつつある中で、皮質各領域間のfunctional connectivity (FC) が重要視されている。脳卒中後は主に半球内，半球間のFCの低下が報告されており，運動機能のバイオマーカーとして注目されている。FC は研究領域では測定されているものの，機器や費用面からリハビリテーション領域への応用には課題が多い。脳波 (EEG) は比較的安価でベッドサイド等でも簡便に測定可能である。本研究では脳卒中１症例を対象にEEGを用い，運動関連領域6電極に限定してFCを解析し，運動機能との関連を調べた。【方法】 対象は脳梗塞 (左内包後脚～放線冠) で右片麻痺を呈した40歳代男性１名とした。運動機能はSIAS運動項目 (SIAS-m) ，Fugl-Meyer 評価法上肢項目 (FMAU) ・下肢項目 (FMAL) ，簡易上肢機能検査 (STEF) を用いて評価した。EEGは日本電気三栄社製 Biotop (6R-12) を用い，国際10-10法に準じてC3, C4, FC3, FC4, Cz, FCzの6電極で測定した (sampling周波数1000Hz) 。課題条件は麻痺側手指運動 (手指条件) および足関節底背屈運動 (足条件) 各30秒間とした。解析はBrainstormを用い，notch filter，band pass filter 0.5-100Hzで前処理後，β帯域 (12-30Hz) における各電極間のFCをamplitude envelope correlation (AEC) にて分析した。評価・測定は発症後1ヶ月，2ヶ月および9ヶ月に実施した。【結果】 運動機能に関してSIAS-mは発症後1 / 2 / 9ヶ月の順に 3-1,4-4-1 / 3-1,4-4-1 / 4-4,4-4-1だった。上肢はFMAU 45 / 53 / 66，STEF 36 / 51 / 81と経時的に改善，下肢はFMAL 20 / 25 / 27であった。AECは，手指条件では機能改善に伴い半球間 (C3-C4，FC3-FC4) および非損傷半球内 (C4-FC4) で減少，損傷半球内 (C3-FC3) は変化なかった。一方，足条件では半球間および損傷半球内は機能変化に伴い若干増加し，非損傷半球内は変化なかった。また運動前領域正中~損傷半球 (FCz-C3，FCz-FC3) および非損傷半球 (FCz-C4，FCz-FC4) では2条件とも経時的に増加した。【考察】 上肢機能は手指で顕著に改善した。機能回復レベルには非損傷半球からの半球間抑制が関与する (Silasi et al., 2014) ため，手指条件での半球間および非損傷半球内のAECの減少は半球間抑制の減弱を反映していると推察した。一方，足条件のAECは手指と異なり半球間抑制の減弱に値する変化を示さなかった。これは手指と足での半球間抑制の違い (Volz et al., 2015) や，足関節の麻痺の残存などが原因と考えた。また手指条件での損傷半球内AECが初期から高値で変化がないことから，手指の機能予後を反映する可能性も考えられた。運動前領域正中~損傷半球および非損傷半球間のAECは2条件とも経時的に大きく増加した。この変化は脳卒中後の運動発現に関する神経機序の回復や再構築を示していると推察した。Wu et al. (2015) は機能回復の程度は損傷側の運動野と運動前野のFCに相関すると報告しており，本研究でも類似の変化が認められた。今後多数症例でこれらの仮説の検証を行いたい。【倫理的配慮，説明と同意】本研究はヘルシンキ宣言を遵守し，名古屋大学医学部医学系研究科生命倫理審査委員会（承認番号17-602），および刈谷豊田総合病院倫理委員会（第302号）の承認を得て実施した。対象者には書面にて本人に研究の趣旨を説明し，同意を得た。

DOI： 10.14900/cjpt.46s1.e-63_1

CiNii Research

Evaluation of the brain function for the myoelectric hand prosthesis with tacit learning system

Iwatsuki, K., Oyama, S., Hoshiyama, M., Shimoda, S., Hirata, H.

Biosystems and Biorobotics Vol. 21 page： 248 - 251 2019

Assessment of attention function recovery in patients after stroke using sequential desk-top tasks

Tanikaga Miki, Muzuno Jumpei, Tanaka Masahiro, Hoshiyama Minoru

INTERNATIONAL JOURNAL OF THERAPY AND REHABILITATION Vol. 25 ( 12 ) page： 665-674 - 674 2018.12

Language：English Publishing type：Research paper (scientific journal) Publisher：MARK ALLEN GROUP

Background/Aims: The course of recovery of performance with attention function has not been sufficiently investigated during the period for rehabilitation after stroke. A sequential desk-top task was applied, whose performance required the spatiotemporal attention function step by step, to patients after stroke. The relationship between the sequential task and conventional assessments of cognitive function was also assessed.Methods: A sequential desk-top task with 13 levels of peg-carrying performance, which involved attention function, was applied to 24 patients with a disturbance of attention function after stroke. The outcomes of the sequential task were compared with the results of the Mini-Mental State Examination, Trail Making Test Part A and B, Hamamatsu type Japanese syllabary selection test sentence (Syllabary), Paced Auditory Serial Addition Test, Ponsford's Attentional Rating Scale, and Functional Independence Measure.Findings: All participants showed significant progress in the level of the sequential desk-top task. The levels achieved in the sequential task were correlated with the scores of Mini-Mental State Examination, Trail Making Test Part A, Paced Auditory Serial Addition Test, Syllabary, and Functional Independence Measure.Conclusions: The results of the sequential desk-top task suggested the recovery course of the attention function, and the results of the task predicted the functional recovery revealed by other test batteries.

DOI： 10.12968/ijtr.2018.25.12.665

Brain Activity on Observation of Another Person's Action: A Magnetoencephalographic Study. International journal

Mizuno J, Kawamura M, Hoshiyama M

Motor control Vol. 22 ( 4 ) page： 377 - 390 2018.10

Language：English Publishing type：Research paper (scientific journal)

Brain activity was recorded using a whole-head magnetoencephalography system followed by coherence analysis to assess neural connectivity in 10 healthy right-handed adults to clarify differences in neural connectivity in brain regions during action observation from several perspectives. The subjects were instructed to observe and memorize or imitate the hand action from a first-person or second-person visual perspective. The brain activity in coherence was modified among frontal and central, sensorimotor, and mirror neuron system-related regions based on the visual perspectives of finger movements. The regional activity in coherence changed similarly under the imitation and observation tasks compared with the condition of observing static hand figures. The information from different visual perspectives of body movements was processed in the frontal-central regions related to sensorimotor processes and partially in mirror neuron system.

DOI： 10.1123/mc.2017-0053