Faculty Profiles - HOSHIYAMA, Minoru

脳磁図による疼痛病態特異的な機能異常の検出と解析．

岩月克之, 寳珠山稔

ペインクリニック Vol. 40 page： 1179 - 1185 2019

Feed-forward-related neural activity for vocalization: A pilot study using magnetoencephalography Reviewed

寳珠山稔

Neurology, Psychiatry and Brain Research Vol. 27 page： 21 - 26 2018

Connectivity of neural signals to the primary motor area during preparatory periods for movement following external and internal cues. International journal

Jumpei Kudo, Minoru Hoshiyama

Somatosensory & motor research Vol. 42 ( 1 ) page： 28 - 37 2025.1

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: We investigated the connectivity of neural signals from movement-related cortical areas to the primary motor area (M1) in the hemisphere contralateral to the movement side during the period of movement-related magnetic fields before movement. MATERIALS AND METHODS: Participants were 13 healthy adults, and nerual signals were recorded using magnetoencephalography. Spontaneous extension of the right wrist was performed at the participant's own pace and following a visual cue in internal (IC) and external (EC) cue tasks. The connectivity of neural signals to M1 from each movement-related motor area was assessed by Granger causality analysis (GCA). The GCA was performed on the neural activity elicited in a frequency band between 7.8 and 46.9 Hz during the pre-movement periods, which occurred durng the readiness field (RF) and the negative slope prime (NSp). F-values, as connectivity values obtained by GCA, were compared between the EC and IC cue tasks. RESULTS: For NSp periods, the connectivity of neural signals from the left superior frontal area (SF-L) to M1 was dominant in the IC task, whereas that from the left superior parietal area (SP-L) to M1 was dominant in the EC task. The F value in the GCA from SP-L to M1 was greater in the EC task during RF than in the IC task during equivalent periods. CONSLUSIONS: In the present study, there were differences in the connectivity of neural signals to M1 between IC and EC tasks. The present results suggested that the pattern of pre-movement neural activity that resulted in a movement was not uniform but differed between movement tasks just before the movement.

DOI： 10.1080/08990220.2024.2319592

Imbalance in positive and negative acceleration ratio of alpha oscillation in patients with complex regional pain syndrome. International journal Open Access

Misako Sano, Katsuyuki Iwatsuki, Hitoshi Hirata, Minoru Hoshiyama

Heliyon Vol. 10 ( 17 ) page： e36463 2024.9

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: To elucidate the functional characteristics of the brain in the presence of chronic pain using electroencephalography (EEG), with a focus on the dynamics of neural excitation and inhibition. METHODS: Resting-state EEG was performed in: 17 patients with complex regional pain syndrome (CRPS) who exhibited chronic pain higher than 20 on the visual analogue scale (VAS), 6 patients with reduced CRPS symptoms and chronic pain less than 20 on VAS, and healthy age-matched controls. For the analysis, 50 s of electroencephalogram (EEG) signals were extracted from EEG recordings during wakefulness and rest with eyes closed. The envelope of the alpha frequency band was calculated by examining the positive and negative accelerations of the envelope oscillation, ratio of positive (Ap) to negative (An) accelerations (Ap-An ratio), and mean amplitude of the envelope. Comparisons were made between patients and controls, and correlations between these EEG measures and the subjective pain VAS were evaluated.Significant differences in the value of Ap, An and Ap-An ratio were observed at temporal and central electrodes between patients with pain symptoms and controls. Those with reduced CRPS symptoms exhibited a distinct Ap-An ratio at the majority of electrodes when compared with those exhibiting chronic pain. CONCLUSIONS: Distinct patterns in alpha wave envelope dynamics, reflecting excitatory and inhibitory activities, were associated with chronic pain in patients with CRPS. The pain-relieved state of CRPS suggested that a new balance of activities was established. This relationship indicated a potential association between altered alpha oscillation characteristics and the subjective experience of pain. SIGNIFICANCE: This study introduces a novel method for analyzing alpha oscillation envelopes, providing new insights into the neural pathophysiology of chronic pain in CRPS patients. This approach has the potential to enhance our understanding of the alterations in brain function that occur under chronic pain conditions.

DOI： 10.1016/j.heliyon.2024.e36463

Analysis of the alpha activity envelope in electroencephalography in relation to the ratio of excitatory to inhibitory neural activity. International journal Open Access

Misako Sano, Yuko Nishiura, Izumi Morikawa, Aiko Hoshino, Jun-Ichi Uemura, Katsuyuki Iwatsuki, Hitoshi Hirata, Minoru Hoshiyama

PloS one Vol. 19 ( 6 ) page： e0305082 2024.6

Language：English Publishing type：Research paper (scientific journal)

Alpha waves, one of the major components of resting and awake cortical activity in human electroencephalography (EEG), are known to show waxing and waning, but this phenomenon has rarely been analyzed. In the present study, we analyzed this phenomenon from the viewpoint of excitation and inhibition. The alpha wave envelope was subjected to secondary differentiation. This gave the positive (acceleration positive, Ap) and negative (acceleration negative, An) values of acceleration and their ratio (Ap-An ratio) at each sampling point of the envelope signals for 60 seconds. This analysis was performed on 36 participants with Alzheimer's disease (AD), 23 with frontotemporal dementia (FTD) and 29 age-matched healthy participants (NC) whose data were provided as open datasets. The mean values of the Ap-An ratio for 60 seconds at each EEG electrode were compared between the NC and AD/FTD groups. The AD (1.41 ±0.01 (SD)) and FTD (1.40 ±0.02) groups showed a larger Ap-An ratio than the NC group (1.38 ±0.02, p<0.05). A significant correlation between the envelope amplitude of alpha activity and the Ap-An ratio was observed at most electrodes in the NC group (Pearson's correlation coefficient, r = -0.92 ±0.15, mean for all electrodes), whereas the correlation was disrupted in AD (-0.09 ±0.21, p<0.05) and disrupted in the frontal region in the FTD group. The present method analyzed the envelope of alpha waves from a new perspective, that of excitation and inhibition, and it could detect properties of the EEG, Ap-An ratio, that have not been revealed by existing methods. The present study proposed a new method to analyze the alpha activity envelope in electroencephalography, which could be related to excitatory and inhibitory neural activity.

DOI： 10.1371/journal.pone.0305082

Cerebellar and thalamic connector hubs facilitate the involvement of visual and cognitive networks in essential tremor. International journal

Epifanio Bagarinao, Satoshi Maesawa, Sachiko Kato, Manabu Mutoh, Yoshiki Ito, Tomotaka Ishizaki, Takafumi Tanei, Takashi Tsuboi, Masashi Suzuki, Hirohisa Watanabe, Minoru Hoshiyama, Haruo Isoda, Masahisa Katsuno, Gen Sobue, Ryuta Saito

Parkinsonism & related disorders Vol. 121 page： 106034 - 106034 2024.4

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: Connector hubs are specialized brain regions that connect multiple brain networks and therefore have the potential to affect the functions of multiple systems. This study aims to examine the involvement of connector hub regions in essential tremor. METHODS: We examined whole-brain functional connectivity alterations across multiple brain networks in 27 patients with essential tremor and 27 age- and sex-matched healthy controls to identify affected hub regions using a network metric called functional connectivity overlap ratio estimated from resting-state functional MRI. We also evaluated the relationships of affected hubs with cognitive and tremor scores in all patients and with motor function improvement scores in 15 patients who underwent postoperative follow-up evaluations after focused ultrasound thalamotomy. RESULTS: We have identified affected connector hubs in the cerebellum and thalamus. Specifically, the dentate nucleus in the cerebellum and the dorsomedial thalamus exhibited more extensive connections with the sensorimotor network in patients. Moreover, the connections of the thalamic pulvinar with the visual network were also significantly widespread in the patient group. The connections of these connector hub regions with cognitive networks were negatively associated (FDR q < 0.05) with cognitive, tremor, and motor function improvement scores. CONCLUSION: In patients with essential tremor, connector hub regions within the cerebellum and thalamus exhibited widespread functional connections with sensorimotor and visual networks, leading to alternative pathways outside the classical tremor axis. Their connections with cognitive networks also affect patients' cognitive function.

DOI： 10.1016/j.parkreldis.2024.106034

Resting-state Electroencephalography Microstates Correlate with Pain Intensity in Patients with Complex Regional Pain Syndrome. International journal

Michihiro Osumi, Masahiko Sumitani, Katsuyuki Iwatsuki, Minoru Hoshiyama, Ryota Imai, Shu Morioka, Hitoshi Hirata

Clinical EEG and neuroscience Vol. 55 ( 1 ) page： 121 - 129 2024.1

Language：English Publishing type：Research paper (scientific journal)

Objective: Severe pain and other symptoms in complex regional pain syndrome (CRPS), such as allodynia and hyperalgesia, are associated with abnormal resting-state brain network activity. No studies to date have examined resting-state brain networks in CRPS patients using electroencephalography (EEG), which can clarify the temporal dynamics of brain networks. Methods: We conducted microstate analysis using resting-state EEG signals to prospectively reveal direct correlations with pain intensity in CRPS patients (n = 17). Five microstate topographies were fitted back to individual CRPS patients' EEG data, and temporal microstate measures were subsequently calculated. Results: Our results revealed five distinct microstates, termed microstates A to E, from resting EEG data in patients with CRPS. Microstates C, D and E were significantly correlated with pain intensity before pain treatment. Particularly, microstates D and E were significantly improved together with pain alleviation after pain treatment. As microstates D and E in the present study have previously been related to attentional networks and the default mode network, improvement in these networks might be related to pain relief in CRPS patients. Conclusions: The functional alterations of these brain networks affected the pain intensity of CRPS patients. Therefore, EEG microstate analyses may be used to identify surrogate markers for pain intensity.

DOI： 10.1177/15500594231204174

Recovery of autonomic dysfunction assessed by heart rate variability after acute stroke: an observational study

複合性局所疼痛症候群患者におけるα-皮質活動の興奮-抑制バランス

岩月克之, 寶珠山稔, 佐伯総太, 徳武克浩, 米田英正, 栗本秀, 山本美知郎, 建部将広, 吉田彬人, 平田仁

末梢神経 Vol. 34 ( 2 ) page： 291 - 291 2023.12

Connectivity alteration in thalamic nuclei and default mode network-related area in memory processes in mesial temporal lobe epilepsy using magnetoencephalography. International journal Open Access

Tomotaka Ishizaki, Satoshi Maesawa, Daisuke Nakatsubo, Hiroyuki Yamamoto, Jun Torii, Manabu Mutoh, Jun Natsume, Minoru Hoshiyama, Ryuta Saito

Scientific reports Vol. 13 ( 1 ) page： 10632 - 10632 2023.6

Language：English Publishing type：Research paper (scientific journal)

This work aimed to investigate the involvement of the thalamic nuclei in mesial temporal lobe epilepsy (MTLE) and identify the influence of interictal epileptic discharges on the neural basis of memory processing by evaluating the functional connectivity (FC) between the thalamic nuclei and default mode network-related area (DMNRA) using magnetoencephalography. Preoperative datasets of nine patients with MTLE with seizure-free status after surgery and those of nine healthy controls were analyzed. The FC between the thalamic nuclei (anterior nucleus [ANT], mediodorsal nucleus [MD], intralaminar nuclei [IL]), hippocampus, and DMNRA was examined for each of the resting, pre-spike, spike, and post-spike periods in the delta to ripple bands using magnetoencephalography. The FC between the ANT, MD, hippocampus, and medial prefrontal cortex increased in the gamma to ripple bands, whereas the FC between the ANT, IL, and DMNRA decreased in the delta to beta bands, compared with that of the healthy controls at rest. Compared with the rest period, the pre-spike period had significantly decreased FC between the ANT, MD, and DMNRA in the ripple band. Different FC changes between the thalamic nuclei, hippocampus, and DMNRA of specific connections in a particular band may reflect impairment or compensation in the memory processes.

DOI： 10.1038/s41598-023-37834-2

Takashi Hoshino, Kazuyo Oguchi, Aiko Hoshino, Minoru Hoshiyama

International Journal of Therapy and Rehabilitation Vol. 30 ( 6 ) page： 1 - 11 2023.6

Publishing type：Research paper (scientific journal) Publisher：Mark Allen Group

Background/Aims

Early mobilisation after acute stroke is recommended worldwide, and autonomic dysfunction is a common complication. However, little is known about autonomic adaptation to postural changes during early mobilisation. The aim of the present study was to clarify the recovery process of autonomic dysfunction after acute stroke regarding adaptation to postural changes.

Methods

A total of 23 patients (mean age 60 ± 11 years) were included in this observational study. Those with a history of arrhythmia, heart failure and diabetes mellitus with diabetic neuropathy were excluded. Autonomic functions were assessed using heart rate variability. Electrocardiograms were recorded when the patients were lying down, sitting up and then lying back down again for 5 minutes in each position. The indices of heart rate variability, total power, high frequency band and low frequency/high frequency ratio, which correspond to total, parasympathetic and sympathetic activity respectively, were calculated to evaluate participants’ autonomic function during the 7 days after the onset of stroke.

Results

From days 3 to 7 after stroke onset, the low frequency/high frequency ratio was significantly higher, and the total power and high frequency were reciprocally lower in the sitting position than in the supine position. On day 7, the total power and high frequency were significantly higher while the low frequency/high frequency ratio was lower than the total power and high frequency values that were recorded on the second and third days after stroke. Blood pressure levels and heart rates also changed, corresponding to changes in heart rate variability.

Conclusions

The patients’ autonomic function, as well as heart rate and blood pressure levels, changed gradually during the first 7 days after onset of stroke. The results could lead to optimised clinical practice in safe early stroke rehabilitation.

DOI： 10.12968/ijtr.2021.0033

慢性疼痛患者と複合性局所疼痛症候群患者における脳可塑性の変化の比較

岩月克之, 寳珠山稔, 徳武克浩, 米田英正, 栗本秀, 山本美知郎, 建部将広, 平田仁

日本手外科学会雑誌 Vol. 40 ( 1 ) page： O50 - 6 2023.4

Relationship Between Psychological Factors and Wound Occurrence in Patients With Peripheral Arterial Disease in the Leg. International journal

Ayaka Onoyama, Minoru Hoshiyama, Hiroki Yabe

The international journal of lower extremity wounds Vol. 21 ( 3 ) page： 312 - 319 2022.9

Language：English Publishing type：Research paper (scientific journal) Publisher：SAGE PUBLICATIONS INC

This prospective study investigated psychological factors affecting wound healing in patients with peripheral arterial disease (PAD). Fifty patients with PAD in a local hospital were enrolled. The Geriatric Depression Scale short version, Type-D scale 14, Medical Outcome Study 36-Item Short-Form Health Survey (SF-36), Functional Independence Measure, Self-efficacy for Managing Chronic Disease Scale, Barriers Self-Efficacy Scale, and Mini Nutritional Assessment were applied to assess physical and psychological factors. Wound occurrence and healing were evaluated at 6 months after discharge, and 34 and 30 patients could be followed, respectively. The patient group with wound occurrence showed poorer mental component score (MCS) and better role/social component score (RCS) category scores of SF-36, and a higher stage in the Fontaine classification, than those without wound occurrence. On comparing Fontaine classification-matched subgroups, patients with wound occurrence showed poorer general health factor and MCS and better RCS of SF-36 than those without wound occurrence. Logistic analysis showed that MCS and RCS predicted wound occurrence and needs for local medical treatment, respectively. Among the psychological factors tested, MCS was a major factor associated with wound occurrence in the present study, with wide variation in clinical conditions and factors associated with PAD. Psychological factors were important as biological, physical, and social factors for patients with PAD during the long-term follow-up period, and an appropriate battery to evaluate psychological factors focused on patients with PAD should be developed.

DOI： 10.1177/1534734620943813

特集運動器慢性疼痛の病態と治療慢性疼痛と脳神経活動

Functional connector hubs in the cerebellum. International journal Open Access

Kazuya Kawabata, Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Reiko Ohdake, Michihito Masuda, Aya Ogura, Toshiyasu Kato, Shuji Koyama, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

NeuroImage Vol. 257 page： 119263 - 119263 2022.8

Language：English Publishing type：Research paper (scientific journal)

Accumulating evidence from anatomical and neuroimaging studies suggests that the cerebellum is engaged in a variety of motor and cognitive tasks. Given its various functions, a key question is whether the cerebellum also plays an important role in the brain's integrative functions. Here, we hypothesize the existence of connector regions, also known as connector hubs, where multiple resting state networks converged in the cerebellum. To verify this, we employed a recently developed voxel-level network measure called functional connectivity overlap ratio (FCOR), which could be used to quantify the spatial extent of a region's connection to several large-scale cortical networks. Using resting state functional MRI data from 101 healthy participants, cerebellar FCOR maps were constructed and used to identify the locations of connector hubs in the cerebellum. Results showed that a number of cerebellar regions exhibited strong connectivity with multiple functional networks, verifying our hypothesis. These highly connected regions were located in the posterior cerebellum, especially in lobules VI, VII, and IX, and mainly connected to the core neurocognitive networks such as default mode and executive control networks. Regions associated with the sensorimotor network were also localized in lobule V, VI, and VIII, albeit in small clusters. These cerebellar connector hubs may play an essential role in the processing of information across the core neurocognitive networks.

DOI： 10.1016/j.neuroimage.2022.119263

寳珠山稔

関節外科　基礎と臨床 Vol. 41 ( 7 ) page： 717 - 721 2022.7

Language：Japanese Publisher：メジカルビュー社

＜文献概要＞慢性疼痛を生じている状態では,疼痛に関連する感覚系に変化が生じているばかりではなく広範囲の脳領域に影響が及んでいる。疼痛の認識は,侵害刺激によって生じる一方,脳の基本活動を決定する複数の神経ネットワークやネットワーク相互の変化によって形成されている可能性がある。それらは感覚・運動機能や認知機能,自律神経活動や自己表出などにさまざまな程度で影響を及ぼし,合併症としての機能障害を生じると考えられる。

DOI： 10.18885/jjs.0000001055

CiNii Research

Stepwise tasks for patients with attention deficit:: Improvement of attention function based on the change of the achievement level of the task,and clinical reasoning based on the stepwise task

Tanikaga Miki, Hoshiyama Minoru

Japanese Occupational Therapy Research Vol. 41 ( 1 ) page： 94 - 105 2022.2

Language：Japanese Publisher：Japanese Association of Occupational Therapists

The purpose of this study was to facilitate screening of attentional functions and to simplify clinical reasoning including prognostic predictions of daily activity. We created and conducted stepwise tasks to observe the improvement process of the attention deficit for every achieved level. Subjects were 14 patients (6 males and 8 females, mean age:74.9 (8.7) (SD)) with cerebrovascular diseases, admitted within 2 months of onset. Using the change of the achievement level of this task, we analyzed the improvement process of the attention function and the relationship between outcomes of the task and existing assessments and daily activity. As a result, the achievement level of the task and existing assessments scores of the subjects were significantly improved. In addition, achievement of the tasks in the initial and final stages significantly correlated with the initial and last scores of existing assessments and daily activity. The achievement level in this task suggested that we could infer an achievement level of daily activity in patients with attention deficits. The present study suggests that a program and scene setting on matching the level of individual attention deficits were possible.

DOI： 10.32178/jotr.41.1_94

CiNii Books

CiNii Research

Reserve and Maintenance in the Aging Brain: A Longitudinal Study of Healthy Older Adults. International journal Open Access

Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Kazuya Kawabata, Kazuhiro Hara, Reiko Ohdake, Aya Ogura, Daisuke Mori, Noritaka Yoneyama, Kazunori Imai, Takamasa Yokoi, Toshiyasu Kato, Shuji Koyama, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

eNeuro Vol. 9 ( 1 ) 2022.1

Language：English Publishing type：Research paper (scientific journal)

The aging brain undergoes structural changes even in very healthy individuals. Quantifying these changes could help disentangle pathologic changes from those associated with the normal human aging process. Using longitudinal magnetic resonance imaging (MRI) data from 227 carefully selected healthy human cohort with age ranging from 50 to 80 years old at baseline scan, we quantified age-related volumetric changes in the brain of healthy human older adults. Longitudinally, the rates of tissue loss in total gray matter (GM) and white matter (WM) were 2497.5 and 2579.8 mm3 per year, respectively. Across the whole brain, the rates of GM decline varied with regions in the frontal and parietal lobes having faster rates of decline, whereas some regions in the occipital and temporal lobes appeared relatively preserved. In contrast, cross-sectional changes were mainly observed in the temporal-occipital regions. Similar longitudinal atrophic changes were also observed in subcortical regions including thalamus, hippocampus, putamen, and caudate, whereas the pallidum showed an increasing volume with age. Overall, regions maturing late in development (frontal, parietal) are more vulnerable to longitudinal decline, whereas those that fully mature in the early stage (temporal, occipital) are mainly affected by cross-sectional changes in healthy older cohort. This may suggest that, for a successful healthy aging, the former needs to be maximally developed at an earlier age to compensate for the longitudinal decline later in life and the latter to remain relatively preserved even in old age, consistent with both concepts of reserve and brain maintenance.

DOI： 10.1523/ENEURO.0455-21.2022

Relationship between lower limb function and functional connectivity assessed by EEG among motor-related areas after stroke. International journal

Takashi Hoshino, Kazuyo Oguchi, Kenji Inoue, Aiko Hoshino, Minoru Hoshiyama

Topics in stroke rehabilitation Vol. 28 ( 8 ) page： 614 - 623 2021.11

Language：English Publishing type：Research paper (scientific journal)

Background: Neural connectivity in brain has been known as indicators for neural function and recovery of brain. Although previous studies reported that neural connectivity predicted the recovery of upper limb function after stroke, the relationship between neural connectivity and lower limb function has not been clear.Objectives: To clarify whether functional connectivity (FC) assessed by electroencephalographiy (EEG) with five electrodes placed on motor-related areas could be related to the functional motor recovery of the lower limbs in patients after stroke.Methods: Twenty-four patients with stroke during the recovery phase were recruited. Motor function of the lower limbs was assessed using Fugl-Meyer Assessment lower limb section (FMAL). EEG signals were recorded by five electrodes (C3, C4, FC3, FC4, and FCz) at rest and during ankle movement. Amplitude envelope correlations, as values for FC, were calculated in α (8-12 Hz), β (13-30 Hz), low-β (13-19 Hz), and high-β (20-30 Hz) frequency bands. The predictive regression equation of the FMAL score in the eighth week after stroke (8 W) was created by FCs in the fourth week (4 W).Results: The higher intra-hemispheric FC in both hemispheres in the resting state and during the ankle movement at 4 W was related to a higher lower limb function at 8 W. Additionally, the higher inter-hemispheric FC between M1 on both sides during the ankle movement was related to a higher function recovery.Conclusions: The intra- and inter-hemispheric FC among motor-related areas at 4 W after stroke might be related to the functional recovery of the lower limbs at 8 W.

DOI： 10.1080/10749357.2020.1864986