2022/05/17 更新

写真a

ホウシヤマ ミノル
寳珠山 稔
HOSHIYAMA, Minoru
所属
大学院医学系研究科 総合保健学専攻 予防・リハビリテーション科学 教授
大学院担当
大学院医学系研究科
学部担当
医学部(保健学科)
職名
教授
連絡先
メールアドレス

学位 1

  1. 博士(医学)

研究キーワード 11

  1. 脳波、脳磁図、筋電図、誘発筋電図、事象関連脳反応

  2. 筋電図

  3. AEP

  4. 事象関連脳反応

  5. VEP

  6. P300

  7. MEG

  8. EMG

  9. 誘発筋電図

  10. 脳磁図

  11. 脳波

研究分野 4

  1. その他 / その他  / 神経内科学

  2. その他 / その他  / 臨床神経生理学

  3. その他 / その他  / 神経科学

  4. ライフサイエンス / 神経内科学  / 臨床神経生理学

現在の研究課題とSDGs 1

  1. ヒトの感覚・運動系における脳内情報処理機構に関する研究

経歴 4

  1. 名古屋大学   大学院医学系研究科 総合保健学専攻 予防・リハビリテーション科学   教授

    2020年4月 - 現在

  2. 名古屋大学   大学院医学系研究科 リハビリテーション療法学専攻 作業療法学   教授

    2018年4月 - 2020年3月

  3. 名古屋大学   脳とこころの研究センター 基盤整備部門   教授

    2013年12月 - 2018年3月

  4. 名古屋大学   教授

学歴 2

  1. 名古屋大学   医学研究科   内科系神経内科学

    - 1994年

      詳細を見る

    国名: 日本国

  2. 名古屋大学   医学部

    - 1986年

      詳細を見る

    国名: 日本国

所属学協会 12

  1. 日本臨床神経生理学会   評議員

    2009年4月 - 現在

  2. 日本神経学会   評議員

    2009年4月 - 現在

  3. 日本内科学会

  4. 日本生体磁気学会   評議員

    2007年4月 - 現在

  5. 日本生理学会

  6. 日本てんかん学会

  7. 日本臨床神経生理学会

  8. 日本神経学会

  9. 日本生理学会

  10. 日本生体磁気学会

  11. 日本内科学会

  12. 日本てんかん学会

▼全件表示

 

論文 203

  1. Functional Connector Hubs in the Cerebellum.

    Kawabata K, Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G

    NeuroImage     頁: 119263   2022年4月

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    記述言語:英語  

    DOI: 10.1016/j.neuroimage.2022.119263

    PubMed

  2. 注意機能の変化をみる段階的作業課題とその利用

    谷利 美希, 寳珠山 稔

    作業療法   41 巻 ( 1 ) 頁: 94 - 105   2022年2月

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    記述言語:日本語   出版者・発行元:一般社団法人 日本作業療法士協会  

    注意機能をスクリーニングし,日常生活活動能力の予後予測を含めた臨床的推論を簡易的に行うため,注意障害の病態に基づいて段階づけた課題を設定した.本研究は,設定した課題達成度の変化を観察し,既存の評価との関連性を検証した.対象は発症2ヵ月以内に入院した脳卒中患者14名とした.結果,対象者の課題達成度および評価得点は有意に向上し,課題達成度と神経心理学的検査および日常生活動作能力には有意な相関が認められた.本研究で設定した課題の達成段階を目安にして,注意機能の改善プロセスを概観し,日常生活活動の達成度を推察できる可能性が示唆され,対象者の注意機能に合わせた課題や場面設定をすることが可能と考えられた.

    DOI: 10.32178/jotr.41.1_94

    CiNii Research

  3. Reserve and Maintenance in the Aging Brain: A Longitudinal Study of Healthy Older Adults

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Kawabata Kazuya, Hara Kazuhiro, Ohdake Reiko, Ogura Aya, Mori Daisuke, Yoneyama Noritaka, Imai Kazunori, Yokoi Takamasa, Kato Toshiyasu, Koyama Shuji, Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Ozaki Norio, Sobue Gen

    ENEURO   9 巻 ( 1 )   2022年

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    記述言語:日本語   出版者・発行元:eNeuro  

    The aging brain undergoes structural changes even in very healthy individuals. Quantifying these changes could help disentangle pathologic changes from those associated with the normal human aging process. Using longitudinal magnetic resonance imaging (MRI) data from 227 carefully selected healthy human cohort with age ranging from 50 to 80 years old at baseline scan, we quantified age-related volumetric changes in the brain of healthy human older adults. Longitudinally, the rates of tissue loss in total gray matter (GM) and white matter (WM) were 2497.5 and 2579.8 mm3 per year, respectively. Across the whole brain, the rates of GM decline varied with regions in the frontal and parietal lobes having faster rates of decline, whereas some regions in the occipital and temporal lobes appeared relatively preserved. In contrast, cross-sectional changes were mainly observed in the temporal-occipital regions. Similar longitudinal atrophic changes were also observed in subcortical regions including thalamus, hippocampus, putamen, and caudate, whereas the pallidum showed an increasing volume with age. Overall, regions maturing late in development (frontal, parietal) are more vulnerable to longitudinal decline, whereas those that fully mature in the early stage (temporal, occipital) are mainly affected by cross-sectional changes in healthy older cohort. This may suggest that, for a successful healthy aging, the former needs to be maximally developed at an earlier age to compensate for the longitudinal decline later in life and the latter to remain relatively preserved even in old age, consistent with both concepts of reserve and brain maintenance.

    DOI: 10.1523/ENEURO.0455-21.2022

    Web of Science

    Scopus

    PubMed

  4. Resting State Networks Related to the Maintenance of Good Cognitive Performance During Healthy Aging

    Maesawa Satoshi, Mizuno Satomi, Bagarinao Epifanio, Watanabe Hirohisa, Kawabata Kazuya, Hara Kazuhiro, Ohdake Reiko, Ogura Aya, Mori Daisuke, Nakatsubo Daisuke, Isoda Haruo, Hoshiyama Minoru, Katsuno Masahisa, Saito Ryuta, Ozaki Norio, Sobue Gen

    FRONTIERS IN HUMAN NEUROSCIENCE   15 巻   頁: 753836   2021年11月

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    記述言語:日本語   出版者・発行元:Frontiers in Human Neuroscience  

    Purpose: Maintenance of cognitive performance is important for healthy aging. This study aims to elucidate the relationship between brain networks and cognitive function in subjects maintaining relatively good cognitive performance. Methods: A total of 120 subjects, with equal number of participants from each age group between 20 and 70 years, were included in this study. Only participants with Addenbrooke’s Cognitive Examination – Revised (ACE-R) total score greater than 83 were included. Anatomical T1-weighted MR images and resting-state functional MR images (rsfMRIs) were taken from all participants using a 3-tesla MRI scanner. After preprocessing, several factors associated with age including the ACE-R total score, scores of five domains, sub-scores of ACE-R, and brain volumes were tested. Morphometric changes associated with age were analyzed using voxel based morphometry (VBM) and changes in resting state networks (RSNs) were examined using dual regression analysis. Results: Significant negative correlations with age were seen in the total gray matter volume (GMV, r = −0.58), and in the memory, attention, and visuospatial domains. Among the different sub-scores, the score of the delayed recall (DR) showed the highest negative correlation with age (r = −0.55, p < 0.001). In VBM analysis, widespread regions demonstrated negative correlation with age, but none with any of the cognitive scores. Quadratic approximations of cognitive scores as functions of age showed relatively delayed decline compared to total GMV loss. In dual regression analysis, some cognitive networks, including the dorsal default mode network, the lateral dorsal attention network, the right / left executive control network, the posterior salience network, and the language network, did not demonstrate negative correlation with age. Some regions in the sensorimotor networks showed positive correlation with the DR, memory, and fluency scores. Conclusion: Some domains of the cognitive test did not correlate with age, and even the highly correlated sub-scores such as the DR score, showed delayed decline compared to the loss of total GMV. Some RSNs, especially involving cognitive control regions, were relatively maintained with age. Furthermore, the scores of memory, fluency, and the DR were correlated with the within-network functional connectivity values of the sensorimotor network, which supported the importance of exercise for maintenance of cognition.

    DOI: 10.3389/fnhum.2021.753836

    Web of Science

    Scopus

    PubMed

  5. Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus

    Kawabata Kazuya, Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Ohdake Reiko, Masuda Michihito, Ogura Aya, Kato Toshiyasu, Koyama Shuji, Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Ozaki Norio, Sobue Gen

    ISCIENCE   24 巻 ( 10 ) 頁: 103106   2021年10月

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    記述言語:日本語   出版者・発行元:iScience  

    The thalamus is critical for the brain's integrative hub functions; however, the localization and characterization of the different thalamic hubs remain unclear. Using a voxel-level network measure called functional connectivity overlap ratio (FCOR), we examined the thalamus' association with large-scale resting-state networks (RSNs) to elucidate its connector hub roles. Connections to the core-neurocognitive networks were localized in the anterior and medial parts, such as the anteroventral and mediodorsal nuclei areas. Regions functionally connected to the sensorimotor network were distinctively located around the lateral pulvinar nucleus but to a limited extent. Prominent connector hubs include the anteroventral, ventral lateral, and mediodorsal nuclei with functional connections to multiple RSNs. These findings suggest that the thalamus, with extensive connections to most of the RSNs, is well placed as a critical integrative functional hub and could play an important role for functional integration facilitating brain functions associated with primary processing and higher cognition.

    DOI: 10.1016/j.isci.2021.103106

    Web of Science

    Scopus

    PubMed

  6. 慢性疼痛と皮質活動

    寳珠山 稔

    PAIN RESEARCH   36 巻 ( 1 ) 頁: 42 - 48   2021年4月

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    記述言語:日本語   出版者・発行元:日本疼痛学会  

    DOI: 10.11154/pain.36.42

    CiNii Research

  7. 安静時および運動時のfunctional connectivityの変化による脳卒中後の上肢機能の予後予測

    星野 高志, 小口 和代, 井上 健二, 寳珠山 稔

    理学療法学Supplement   48S1 巻 ( 0 ) 頁: C-181_1 - C-181_1   2021年

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    記述言語:日本語   出版者・発行元:公益社団法人 日本理学療法士協会  

    DOI: 10.14900/cjpt.48s1.c-181_1

    CiNii Research

  8. Action performance in children with autism spectrum disorder at preschool age: a pilot study

    Sano Misako, Yamaguchi Kaori, Fukatsu Reiko, Hoshiyama Minoru

    INTERNATIONAL JOURNAL OF DEVELOPMENTAL DISABILITIES   66 巻 ( 4 ) 頁: 289 - 295   2020年8月

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    記述言語:日本語   出版者・発行元:International Journal of Developmental Disabilities  

    Objectives: Motor deficits related to imitation have been observed in autism spectrum disorder (ASD) patients. This pilot investigation focused on motor performances, including daily tool-use actions, performing an action in the absence of the tool, and imitating (copying tool-use action presented visually), in eight children with ASD and eight children with typical development (TD), with all of pre-school age (4–6 years). Methods: Motor performances were compared between the children with ASD and TD. Differences between an actual tool-use action and performing a tool-use action without the tool according to verbal instruction were also assessed between the groups. Results: Children with ASD showed impairments in imitating, but their actual tool-use actions and tool-use actions without tools following verbal instruction were not different from those of TD children. The spatial error rate in the tasks was higher in children with ASD. Conclusions: The present study indicates that disturbance in imitating actions appears by the age of 4–6 years in children with ASD, possibly as a characteristic symptom affecting motor performance at pre-school age. Generalized apraxia might follow by the age of 8 years or older.

    DOI: 10.1080/20473869.2019.1580472

    Web of Science

    Scopus

    PubMed

  9. Apathy and depression during the recovery stage after stroke

    Kawasaki Megumi, Hoshiyama Minoru

    INTERNATIONAL JOURNAL OF THERAPY AND REHABILITATION   27 巻 ( 5 ) 頁: 1 - 12   2020年5月

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    記述言語:日本語   出版者・発行元:International Journal of Therapy and Rehabilitation  

    Background/Aims Both apathy and depression occur during the recovery period following stroke; however, the relationship between post-stroke apathy and depression is still unclear. The present study investigated the clinical course of apathy and its association with depression, cognitive function and daily function during the recovery period after stroke. Methods A total of 42 patients (29 male and 13 female, aged 69.1 ± 12.4 years) who had experienced stroke participated in this study. Each participant was assessed using the Apathy Scale, Self-rating Depression Scale, Mini-Mental State Examination, Clinical Assessment of Attention and Trail-Making-Test parts A and B. Quality of life was evaluated using the Stroke Specific Quality of Life Scale. Physical function and functional status were assessed using the Brunnstrom Stages of Stroke Recovery and Functional Independence Measure respectively. Results The incidence of apathy did not change from the time of admission to discharge. Apathy Scale score did not correlate with Self-rating Depression Scale score at admission, but it did correlate at the time of discharge. Patients with apathy after stroke suffered from greater cognitive disturbance and attention and executive dysfunctions than those without apathy. Total Functional Independence Measure score did not correlate with Apathy Scale or Self-rating Depression Scale score, but there was an association between Self-rating Depression Scale score and the Functional Independence Measure motor and Brunnstrom scores at discharge. Conclusions Apathy and depression had different relationships with cognitive and physical function during the recovery stage after stroke. The prevalence of apathy and depression changed, with the interrelationship between apathy and depression altering during the recovery period. Symptoms of apathy and depression should be distinguished from each other and appropriately evaluated to provide effective intervention to support physical and mental recovery after stroke.

    DOI: 10.12968/ijtr.2018.0070

    Web of Science

    Scopus

  10. Effect of environmental music on autonomic function in infants in intensive and growing care units

    Hasegawa Y., Hoshiyama M.

    Journal of Neonatal-Perinatal Medicine   13 巻 ( 3 ) 頁: 395 - 401   2020年

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    記述言語:日本語   出版者・発行元:Journal of Neonatal-Perinatal Medicine  

    BACKGROUND: The aim of this study is (1) to observe the effect of the background music (BGM) in the incubator on heart rate variability (HRV) during the first few weeks of life in preterm infants in the neonatal intensive (NICU) and growing care units (GCU) and (2) to investigate the effect of environmental music on autonomic function in the infants. METHODS: Thirty infants, including premature (26 3/7 - 38 4/7 weeks) and low-birth weight (LBW) (946-2,440 g) infants, admitted to the NICU or GCU were involved. The heart rate, low- (LF, 0.05-0.15 Hz) and high- (HF, 0.15-0.4 Hz) frequency HRV components, and LF/HF ratio were measured. The BGM, lullabies for a baby, was delivered through a speaker in the incubator, and the HRV components were compared among before, during, and after intervention with BGM. RESULTS: The mean HR did not change among the experimental conditions. The LF and HF values decreased during the BGM condition, but not LF/HF, compared with the condition before BGM. CONCLUSIONS: The present results showed that an auditory environment affected the autonomic function of infants with a range of BGM in the NICU/GCU. The present study also suggested that BGM, a non-invasive and non-pharmacological intervention, could be an evaluation tool for autonomic function in infants in NICU/GCU.

    DOI: 10.3233/NPM-180174

    Scopus

  11. 運動関連領域脳波のfunctional connectivityによる脳卒中後の上肢機能の予後予測

    星野 高志, 小口 和代, 井上 健二, 寳珠山 稔

    理学療法学Supplement   47S1 巻 ( 0 ) 頁: F-83_2 - F-83_2   2020年

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    記述言語:日本語   出版者・発行元:公益社団法人 日本理学療法士協会  

    DOI: 10.14900/cjpt.47s1.f-83_2

    CiNii Research

  12. 研究と報告 姿勢変換に伴う自律神経活動の変化-若年健常者での検討

    星野 高志, 小口 和代, 寳珠山 稔

    総合リハビリテーション   47 巻 ( 5 ) 頁: 463 - 468   2019年5月

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    出版者・発行元:株式会社医学書院  

    DOI: 10.11477/mf.1552201638

    CiNii Research

  13. 脳磁図による疼痛病態特異的な機能異常の検出と解析.

    岩月 克之, 寳珠山 稔

    ペインクリニック   40 巻   頁: 1179 - 1185   2019年

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  14. 脳卒中後の運動機能とfunctional connectivityの変化

    星野 高志, 小口 和代, 寳珠山 稔

    理学療法学Supplement   46S1 巻 ( 0 ) 頁: E-63_1 - E-63_1   2019年

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    記述言語:日本語   出版者・発行元:公益社団法人 日本理学療法士協会  

    <p>【はじめに・目的】 </p><p>脳活動のネットワークとしての機能が明らかにされつつある中で、皮質各領域間のfunctional connectivity (FC) が重要視されている。脳卒中後は主に半球内,半球間のFCの低下が報告されており,運動機能のバイオマーカーとして注目されている。FC は研究領域では測定されているものの,機器や費用面からリハビリテーション領域への応用には課題が多い。脳波 (EEG) は比較的安価でベッドサイド等でも簡便に測定可能である。本研究では脳卒中1症例を対象にEEGを用い,運動関連領域6電極に限定してFCを解析し,運動機能との関連を調べた。</p><p>【方法】 </p><p>対象は脳梗塞 (左内包後脚~放線冠) で右片麻痺を呈した40歳代男性1名とした。運動機能はSIAS運動項目 (SIAS-m) ,Fugl-Meyer 評価法 上肢項目 (FMAU) ・下肢項目 (FMAL) ,簡易上肢機能検査 (STEF) を用いて評価した。EEGは日本電気三栄社製 Biotop (6R-12) を用い,国際10-10法に準じてC3, C4, FC3, FC4, Cz, FCzの6電極で測定した (sampling周波数1000Hz) 。課題条件は麻痺側手指運動 (手指条件) および足関節底背屈運動 (足条件) 各30秒間とした。解析はBrainstormを用い,notch filter,band pass filter 0.5-100Hzで前処理後,β帯域 (12-30Hz) における各電極間のFCをamplitude envelope correlation (AEC) にて分析した。評価・測定は発症後1ヶ月,2ヶ月および9ヶ月に実施した。</p><p>【結果】 </p><p>運動機能に関してSIAS-mは発症後1 / 2 / 9ヶ月の順に 3-1,4-4-1 / 3-1,4-4-1 / 4-4,4-4-1だった。上肢はFMAU 45 / 53 / 66,STEF 36 / 51 / 81と経時的に改善,下肢はFMAL 20 / 25 / 27であった。AECは,手指条件では機能改善に伴い半球間 (C3-C4,FC3-FC4) および非損傷半球内 (C4-FC4) で減少,損傷半球内 (C3-FC3) は変化なかった。一方,足条件では半球間および損傷半球内は機能変化に伴い若干増加し,非損傷半球内は変化なかった。また運動前領域正中~損傷半球 (FCz-C3,FCz-FC3) および非損傷半球 (FCz-C4,FCz-FC4) では2条件とも経時的に増加した。</p><p>【考察】 </p><p>上肢機能は手指で顕著に改善した。機能回復レベルには非損傷半球からの半球間抑制が関与する (Silasi et al., 2014) ため,手指条件での半球間および非損傷半球内のAECの減少は半球間抑制の減弱を反映していると推察した。一方,足条件のAECは手指と異なり半球間抑制の減弱に値する変化を示さなかった。これは手指と足での半球間抑制の違い (Volz et al., 2015) や,足関節の麻痺の残存などが原因と考えた。また手指条件での損傷半球内AECが初期から高値で変化がないことから,手指の機能予後を反映する可能性も考えられた。運動前領域正中~損傷半球および非損傷半球間のAECは2条件とも経時的に大きく増加した。この変化は脳卒中後の運動発現に関する神経機序の回復や再構築を示していると推察した。Wu et al. (2015) は機能回復の程度は損傷側の運動野と運動前野のFCに相関すると報告しており,本研究でも類似の変化が認められた。今後多数症例でこれらの仮説の検証を行いたい。</p><p>【倫理的配慮,説明と同意】</p><p>本研究はヘルシンキ宣言を遵守し,名古屋大学医学部医学系研究科生命倫理審査委員会(承認番号17-602),および刈谷豊田総合病院倫理委員会(第302号)の承認を得て実施した。対象者には書面にて本人に研究の趣旨を説明し,同意を得た。</p>

    DOI: 10.14900/cjpt.46s1.e-63_1

    CiNii Research

  15. Evaluation of the Brain Function for the Myoelectric Hand Prosthesis with Tacit Learning System

    Iwatsuki Katsuyuki, Oyama Shintaro, Hoshiyama Minoru, Shimoda Shingo, Hirata Hitoshi

    CONVERGING CLINICAL AND ENGINEERING RESEARCH ON NEUROREHABILITATION III   21 巻   頁: 248 - 251   2019年

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    記述言語:日本語   出版者・発行元:Biosystems and Biorobotics  

    We developed a myoelectric hand prosthesis equipped with the tacit learning system (TLS) to auto-regulate forearm rotation in response to upper extremity movement patterns. We evaluated the tacit learning effects on the central nervous system during a prosthesis control exercise. The experienced prosthetic user performed a series of simple mechanical tasks with the system inactivated (the baseline, normal condition) and then with it activated (the enhanced, experimental condition). The process was video recorded. Video 1 documents the ordinary TLS-inactive condition while Video 2 documents the TLS-active condition. Subsequently, the participant viewed each video under experimental conditions during magnetoencephalography and electroencephalography recording. The connections between the motor area and the other cortical areas were observed with a significant increase in the coherence value. Results suggest integration and interoperability as the process undergirding tacit learning promotes motor function related adaptive neuroplasticity.

    DOI: 10.1007/978-3-030-01845-0_49

    Web of Science

    Scopus

  16. Study on Estimation of MMSE Score by Using the Latency of P300 and Alpha Wave

    Miwa Koki, Yoshikawa Tomohiro, Furuhashi Takeshi, Hoshiyama Minoru, Makino Taeko, Yanagawa Madoka, Suzuki Yusuke, Umegaki Hiroyuki, Kuzuya Masafumi

    2018 JOINT 10TH INTERNATIONAL CONFERENCE ON SOFT COMPUTING AND INTELLIGENT SYSTEMS (SCIS) AND 19TH INTERNATIONAL SYMPOSIUM ON ADVANCED INTELLIGENT SYSTEMS (ISIS)     頁: 195 - 199   2018年

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    記述言語:日本語   出版者・発行元:Proceedings - 2018 Joint 10th International Conference on Soft Computing and Intelligent Systems and 19th International Symposium on Advanced Intelligent Systems, SCIS-ISIS 2018  

    The number of elderly people with dementia increases year by year, and about 20% of people in Japan over 65 years old are estimated to be dementia patients in 2030. Because dementia is difficult to be treated after the symptoms advance, early detection of dementia is important. The peak latency of P300 is one of the EEG (Electroencephalogram) features. It has been reported that the peak latency of P300 is dependent on MMSE (Mini-Mental State Examination) score. If MMSE score can be estimated by measuring the latency of P300, it is expected to be used for the early detection of dementia. However, no regression equation between MMSE score and the latency of P300 had been identified yet. The authors measured the peak latency of P300 of dementia patients who were attending the Geriatrics of Nagoya University hospital and identified a multiple regression equation with MMSE score as the objective variable, and the latency of P300, age, years of education, alpha wave power as the explanatory variables. The 95% confidence interval of estimated MMSE score was ±3.09.

    DOI: 10.1109/SCIS-ISIS.2018.00041

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  17. Feed-forward-related neural activity for vocalization: A pilot study using magnetoencephalography 査読有り

    寳珠山 稔

    Neurology, Psychiatry and Brain Research   27 巻   頁: 21 - 26   2018年

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  18. MMSEスコア推定におけるα波の偏回帰係数の同定

    三輪 晃暉, 吉川 大弘, 古橋 武, 寳珠山 稔, 牧野 多恵子, 柳川 まどか, 鈴木 祐介, 梅垣 宏之, 葛谷 雅文

    日本知能情報ファジィ学会 ファジィ システム シンポジウム 講演論文集   34 巻 ( 0 ) 頁: 15 - 18   2018年

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    記述言語:日本語   出版者・発行元:日本知能情報ファジィ学会  

    <p>高齢認知症患者数は年々増加し,2030年には65歳以上の約20%が認知症患者となると推定されている.また認知症は,症状が進んでからの治療が困難であるため,早期発見が重要とされている.脳波の特徴量であるP300頂点潜時は,認知症スクリーニング検査のMMSE(Mini Mental State Examination)スコア,課題の難易度,年齢,教育歴とそれぞれ関係があることが,個々に報告されている.そのため,P300頂点潜時を計測することでMMSEスコアを推定できれば,認知症の兆候を捉えられ,認知症早期発見につながると期待される.しかしMMSEスコアとP300頂点潜時等との関係は,これまで定量的には同定されていない.そこで本研究では,名古屋大学医学部附属病院老年内科に通院している患者を対象に,オドボール課題による脳波計測実験を行い,MMSEスコアとP300頂点潜時,課題の難易度,年齢,教育歴,更に認知症と関係性があるといわれているα波の重回帰式を同定した.同定の結果,α波はMMSEスコアの推定に統計的に有意な変数であることがわかった.この重回帰式におけるMMSEスコア推定誤差の 95%信頼区間は±3.19であった.</p>

    DOI: 10.14864/fss.34.0_15

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  19. 好酸球性多発血管炎性肉芽腫症患者に生じた多発性単神経炎とステロイドミオパチーに対する理学療法

    星野 高志, 小口 和代, 寳珠山 稔

    理学療法学   44 巻 ( 3 ) 頁: 226 - 231   2017年

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    記述言語:日本語   出版者・発行元:日本理学療法士学会  

    <p>【目的】多発性単神経炎とステロイドミオパチー(以下,SM)を呈した好酸球性多発血管炎性肉芽腫症(以下,EGPA)患者への理学療法(以下,PT)について報告することである。【方法】症例はEGPA を発症した40 歳代男性で多発性単神経炎により感覚障害を伴う右下垂足と左握力低下に加え,SM が疑われる近位筋力低下を呈していた。入院13 日目より開始したPT ではステロイド量および好酸球数を指標として病勢に応じて低強度の運動からはじめ,下垂足には早期から短下肢装具を使用した。SM に対する筋力強化の是非には議論があるためADL 維持程度に留めた。【結果】右下垂足と左握力低下は残存したが,近位筋力は改善し,装具装着下での歩行が可能となり,入院50 日目に退院した。【結論】EGPA に対し,1)病勢に応じた運動負荷の調節,2)多発性単神経炎による局所症状への対応,3)SM の可能性に留意すること,以上を考慮してPT を実施した。</p>

    DOI: 10.15063/rigaku.11240

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  20. 急性期脳卒中者の自律神経機能の回復過程

    星野 高志, 小口 和代, 寳珠山 稔

    理学療法学Supplement   2016 巻 ( 0 ) 頁: 1023   2017年

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    記述言語:日本語   出版者・発行元:公益社団法人 日本理学療法士協会  

    <p>【はじめに】</p><p></p><p>急性期脳卒中では自律神経機能(autonomic nervous function,ANF)の低下が報告されているが詳細は明らかではない(Orlandi, 2000)。脳卒中早期のリハビリテーション(リハ)において,姿勢変化による血圧変動は脳血流に直接影響するため十分考慮すべき点であり,ANFの測定には非侵襲性,簡便性から心拍変動(heart rate variability,HRV)がよく用いられる(Raedt, 2015)。また,脳卒中の主な併存症である糖尿病(DM)患者においてもANFは低下する(Stuckey, 2013)。本研究ではHRVを用いて急性期脳卒中におけるANFの回復過程をDMの併存に着目して検討した。</p><p></p><p></p><p>【方法】</p><p></p><p>対象は急性期初発脳卒中者のうち,自律神経作動薬の使用者や,著明な不整脈,DM性末梢神経障害を有するものを除外した30名とし,DMのないS群DMを有するDM群に分けた。第7病日までを評価期間とし,各回背臥位(pre),端座位(sit),背臥位(post)の順に姿勢変換した。HRVは各姿勢5分間の心拍データを周波数解析し,高周波成分(HF:0.15~0.4Hz)のnormalized unit(HFnu)を副交感神経,低周波成分(LF:0.04~0.15Hz)とHFの比(LF/HF比)を交感神経の指標とした。心拍数(HR),血圧(SBP,DBP)は3回の平均を用いた。各指標の姿勢変換による影響と経時的変化を検討した。統計処理はTukey-Kramer法,Spearmanの順位相関係数を用い,有意水準は5%未満とした。</p><p></p><p></p><p>【結果】</p><p></p><p>S群は23名(平均60±11歳,NIHSS 8点(中央値)),DM群は7名(59±13歳,NIHSS 5点,HbA1c 6.7%(中央値))であった。S群では第3病日以降,HFnuはsitで低下しpostで上昇,LF/HF比,DBP,HRはsitで上昇しpostで低下する一定の変化を示した。経時的にはLF/HF比,HFnu,SBPおよびHRで第2,第3病日に比べ第7病日で有意差が見られ,HFnuは経過日数と正の相関,LF/HF比,SBP,HRは負の相関を示した。一方,DM群では姿勢変換に対し,第4病日以降,HRのみsitで上昇を示したが,他の指標は第7病日においても一定しなかった。SBPのみ経過日数と負の相関を示した。</p><p></p><p></p><p>【結論】</p><p></p><p>DMのない急性期脳卒中者のANFは,第3病日には交感神経,副交感神経とも姿勢変換に適応して変化し,経時的に副交感神経は第7病日まで日ごとに上昇,交感神経は低下していた。これは,発症直後は交感神経活動が亢進しておりSBP,HRが高値となるが,1週までに副交感神経活動が徐々に上昇することを示唆していた。またDM併存症例では一定の傾向を示さず,1週後でもANFは安定していないと考えられた。これらは脳卒中早期リハ実施におけるリスク管理上,考慮すべき点と考えられた。</p>

    DOI: 10.14900/cjpt.2016.1023

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  21. Relationship between lower limb function and functional connectivity assessed by EEG among motor-related areas after stroke 国際誌

    Hoshino Takashi, Oguchi Kazuyo, Inoue Kenji, Hoshino Aiko, Hoshiyama Minoru

    TOPICS IN STROKE REHABILITATION   28 巻 ( 8 ) 頁: 614 - 623   2021年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Topics in Stroke Rehabilitation  

    Background: Neural connectivity in brain has been known as indicators for neural function and recovery of brain. Although previous studies reported that neural connectivity predicted the recovery of upper limb function after stroke, the relationship between neural connectivity and lower limb function has not been clear. Objectives: To clarify whether functional connectivity (FC) assessed by electroencephalographiy (EEG) with five electrodes placed on motor-related areas could be related to the functional motor recovery of the lower limbs in patients after stroke. Methods: Twenty-four patients with stroke during the recovery phase were recruited. Motor function of the lower limbs was assessed using Fugl-Meyer Assessment lower limb section (FMAL). EEG signals were recorded by five electrodes (C3, C4, FC3, FC4, and FCz) at rest and during ankle movement. Amplitude envelope correlations, as values for FC, were calculated in α (8–12 Hz), β (13–30 Hz), low-β (13–19 Hz), and high-β (20–30 Hz) frequency bands. The predictive regression equation of the FMAL score in the eighth week after stroke (8 W) was created by FCs in the fourth week (4 W). Results: The higher intra-hemispheric FC in both hemispheres in the resting state and during the ankle movement at 4 W was related to a higher lower limb function at 8 W. Additionally, the higher inter-hemispheric FC between M1 on both sides during the ankle movement was related to a higher function recovery. Conclusions: The intra- and inter-hemispheric FC among motor-related areas at 4 W after stroke might be related to the functional recovery of the lower limbs at 8 W.

    DOI: 10.1080/10749357.2020.1864986

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  22. Pre-stimulus alpha oscillation and post-stimulus cortical activity differ in localization between consciously perceived and missed near-threshold somatosensory stimuli 国際誌

    Uemura Jun-ichi, Hoshino Aiko, Igarashi Go, Matsui Yusuke, Chishima Makoto, Hoshiyama Minoru

    EUROPEAN JOURNAL OF NEUROSCIENCE   54 巻 ( 4 ) 頁: 5518 - 5530   2021年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:European Journal of Neuroscience  

    Conscious perception of a near-threshold (NT) stimulus is characterized by the pre- and post-stimulus brain state. However, the power of pre-stimulus neural oscillations and strength of post-stimulus cortical activity that lead to conscious perception have rarely been examined in individual cortical areas. This is because most previous electro- and magnetoencephalography (EEG and MEG, respectively) studies involved scalp- and sensor-level analyses. Therefore, we recorded MEG during a continuous NT somatosensory stimulus detection task and applied the reconstructed source data in order to identify cortical areas where the post-stimulus cortical activity and pre-stimulus alpha oscillation predict the conscious perception of NT somatosensory stimuli. We found that the somatosensory hierarchical processing areas, prefrontal areas and cortical areas belonging to the default mode network showed stronger cortical activity for consciously perceived trials in the post-stimulus period, but the cortical activity in primary somatosensory area (SI) is independent of conscious perception during the early stage of NT stimulus processing. In addition, we revealed that the pre-stimulus alpha oscillation only in SI is predictive of conscious perception. These findings suggest that the bottom-up stream of somatosensory information flow following SI and pre-stimulus alpha activity fluctuation in SI as a top-down modulation are crucial constituents of conscious perception.

    DOI: 10.1111/ejn.15388

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  23. Chronic pain-related cortical neural activity in patients with complex regional pain syndrome 国際誌

    Iwatsuki Katsuyuki, Hoshiyama Minoru, Yoshida Akihito, Uemura Jun-ichi, Hoshino Aiko, Morikawa Izumi, Nakagawa Yasunobu, Hirata Hitoshi

    IBRO NEUROSCIENCE REPORTS   10 巻 ( 1 ) 頁: 208 - 215   2021年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IBRO Neuroscience Reports  

    Quantitative objective measurement of chronic pain is important. We elucidated chronic pain-related cortical neural activity and neural connectivity among pain-related brain regions in complex regional pain syndrome (CRPS). Resting-state magnetoencephalography recordings were performed. Cortical current density and neural connectivity, revealed by amplitude envelope correlation (AEC), were estimated on standardized brain magnetic resonance imaging. Intra-experiment pain was assessed subjectively using a visual analogue scale (VAS). The correlation between current density and VAS scores was calculated for the occipital areas and pain-related cortices. Current density in the primary (SI) and secondary (SII) somatosensory cortex and precuneus in both hemispheres was negatively correlated with the pain VAS score. The AEC and VAS values were significantly correlated for the SII and the precuneus and for the SII and insular cortex in the alpha frequency band in the right hemisphere. In the theta frequency band, the AEC and VAS values correlated for the SII and posterior cingulate cortex in the right hemisphere. Our results suggested that disruption of pain processes and functions in the default mode network occurs in CRPS. Our method targeting the neural mechanism of pain has the potential to offer a clinically objective means of evaluating it.

    DOI: 10.1016/j.ibneur.2021.05.001

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  24. Effects of Head Motion on the Evaluation of Age-related Brain Network Changes Using Resting State Functional MRI

    Kato Sanae, Bagarinao Epifanio, Isoda Haruo, Koyama Shuji, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Katsuno Masahisa, Hoshiyama Minoru, Naganawa Shinji, Ozaki Norio, Sobue Gen

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   20 巻 ( 4 ) 頁: 338 - 346   2021年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    Purpose: The estimation of functional connectivity (FC) measures using resting state functional MRI (fMRI) is often affected by head motion during functional imaging scans. Head motion is more common in the elderly than in young participants and could therefore affect the evaluation of age-related changes in brain networks. Thus, this study aimed to investigate the influence of head motion in FC estimation when evaluating age-related changes in brain networks. Methods: This study involved 132 healthy volunteers divided into 3 groups: elderly participants with high motion (OldHM, mean age (±SD) = 69.6 (±5.31), N = 44), elderly participants with low motion (OldLM, mean age (±SD) = 68.7 (±4.59), N = 43), and young adult participants with low motion (YugLM, mean age (±SD) = 27.6 (±5.26), N = 45). Head motion was quantified using the mean of the framewise displacement of resting state fMRI data. After preprocessing all resting state fMRI datasets, several resting state networks (RSNs) were extracted using independent component analysis (ICA). In addition, several network metrics were also calculated using network analysis. These FC measures were then compared among the 3 groups. Results: In ICA, the number of voxels with significant differences in RSNs was higher in YugLM vs. OldLM comparison than in YugLM vs. OldHM. In network analysis, all network metrics showed significant (P < 0.05) differences in comparisons involving low vs. high motion groups (OldHM vs. OldLM and OldHM vs. YugLM). However, there was no significant (P > 0.05) difference in the comparison involving the low motion groups (OldLM vs. YugLM). Conclusion: Our findings showed that head motion during functional imaging could significantly affect the evaluation of age-related brain network changes using resting state fMRI data.

    DOI: 10.2463/mrms.mp.2020-0081

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  25. Identifying the brain's connector hubs at the voxel level using functional connectivity overlap ratio 国際誌

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Ohdake Reiko, Masuda Michihito, Ogura Aya, Kato Toshiyasu, Koyama Shuji, Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Ozaki Norio, Sobue Gen

    NEUROIMAGE   222 巻   頁: 117241 - 117241   2020年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NeuroImage  

    Neuroimaging studies have shown that the brain is functionally organized into several large-scale brain networks. Within these networks are regions that are widely connected to several other regions within and/or outside the network. Regions that connect to several other networks, known as connector hubs, are believed to be crucial for information transfer and between-network communication within the brain. To identify regions with high between-network connectivity at the voxel level, we introduced a novel metric called functional connectivity overlap ratio (FCOR), which quantifies the spatial extent of a region's connection to a given network. Using resting state functional magnetic resonance imaging data, FCOR maps were generated for several well-known large-scale resting state networks (RSNs) and used to examine the relevant associations among different RSNs, identify connector hub regions in the cerebral cortex, and elucidate the hierarchical functional organization of the brain. Constructed FCOR maps revealed a strong association among the core neurocognitive networks (default mode, salience, and executive control) as well as among primary processing networks (sensorimotor, auditory, and visual). Prominent connector hubs were identified in the bilateral middle frontal gyrus, posterior cingulate, lateral parietal, middle temporal, dorsal anterior cingulate, and anterior insula, among others, regions mostly associated with the core neurocognitive networks. Finally, clustering the whole brain using FCOR features yielded a topological organization that arranges brain regions into a hierarchy of information processing systems with the primary processing systems at one end and the heteromodal systems comprising connector hubs at the other end.

    DOI: 10.1016/j.neuroimage.2020.117241

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  26. Aging Impacts the Overall Connectivity Strength of Regions Critical for Information Transfer Among Brain Networks 国際誌

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Taoka Toshiaki, Koyama Shuji, Tanabe Hiroki C., Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Ozaki Norio, Sobue Gen

    FRONTIERS IN AGING NEUROSCIENCE   12 巻   頁: 592469 - 592469   2020年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Frontiers in Aging Neuroscience  

    Recent studies have demonstrated that connector hubs, regions considered critical for the flow of information across neural systems, are mostly involved in neurodegenerative dementia. Considering that aging can significantly affect the brain’s intrinsic connectivity, identifying aging’s impact on these regions’ overall connection strength is important to differentiate changes associated with healthy aging from neurodegenerative disorders. Using resting state functional magnetic resonance imaging data from a carefully selected cohort of 175 healthy volunteers aging from 21 to 86 years old, we computed an intrinsic connectivity contrast (ICC) metric, which quantifies a region’s overall connectivity strength, for whole brain, short-range, and long-range connections and examined age-related changes of this metric over the adult lifespan. We have identified a limited number of hub regions with ICC values that showed significant negative relationship with age. These include the medial precentral/midcingulate gyri and insula with both their short-range and long-range (and thus whole-brain) ICC values negatively associated with age, and the angular, middle frontal, and posterior cingulate gyri with their long-range ICC values mainly involved. Seed-based connectivity analyses further confirmed that these regions are connector hubs with connectivity profile that strongly overlapped with multiple large-scale brain networks. General cognitive performance was not associated with these hubs’ ICC values. These findings suggest that even healthy aging could negatively impact the efficiency of regions critical for facilitating information transfer among different functional brain networks. The extent of the regions involved, however, was limited.

    DOI: 10.3389/fnagi.2020.592469

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  27. Relationship Between Psychological Factors and Wound Occurrence in Patients With Peripheral Arterial Disease in the Leg 国際誌

    Onoyama Ayaka, Hoshiyama Minoru, Yabe Hiroki

    INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS     頁: 1534734620943813 - 1534734620943813   2020年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Journal of Lower Extremity Wounds  

    This prospective study investigated psychological factors affecting wound healing in patients with peripheral arterial disease (PAD). Fifty patients with PAD in a local hospital were enrolled. The Geriatric Depression Scale short version, Type-D scale 14, Medical Outcome Study 36-Item Short-Form Health Survey (SF-36), Functional Independence Measure, Self-efficacy for Managing Chronic Disease Scale, Barriers Self-Efficacy Scale, and Mini Nutritional Assessment were applied to assess physical and psychological factors. Wound occurrence and healing were evaluated at 6 months after discharge, and 34 and 30 patients could be followed, respectively. The patient group with wound occurrence showed poorer mental component score (MCS) and better role/social component score (RCS) category scores of SF-36, and a higher stage in the Fontaine classification, than those without wound occurrence. On comparing Fontaine classification–matched subgroups, patients with wound occurrence showed poorer general health factor and MCS and better RCS of SF-36 than those without wound occurrence. Logistic analysis showed that MCS and RCS predicted wound occurrence and needs for local medical treatment, respectively. Among the psychological factors tested, MCS was a major factor associated with wound occurrence in the present study, with wide variation in clinical conditions and factors associated with PAD. Psychological factors were important as biological, physical, and social factors for patients with PAD during the long-term follow-up period, and an appropriate battery to evaluate psychological factors focused on patients with PAD should be developed.

    DOI: 10.1177/1534734620943813

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  28. Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis 国際誌

    Choy Shao Wei, Bagarinao Epifanio, Watanabe Hirohisa, Ho Eric Tatt Wei, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Taoka Toshiaki, Koyama Shuji, Tanabe Hiroki C., Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Ozaki Norio, Sobue Gen

    HUMAN BRAIN MAPPING   41 巻 ( 12 ) 頁: 3198 - 3211   2020年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Human Brain Mapping  

    White matter (WM) fiber bundles change dynamically with age. These changes could be driven by alterations in axonal diameter, axonal density, and myelin content. In this study, we applied a novel fixel-based analysis (FBA) framework to examine these changes throughout the adult lifespan. Using diffusion-weighted images from a cohort of 293 healthy volunteers (89 males/204 females) from ages 21 to 86 years old, we performed FBA to analyze age-related changes in microscopic fiber density (FD) and macroscopic fiber morphology (fiber cross section [FC]). Our results showed significant and widespread age-related alterations in FD and FC across the whole brain. Interestingly, some fiber bundles such as the anterior thalamic radiation, corpus callosum, and superior longitudinal fasciculus only showed significant negative relationship with age in FD values, but not in FC. On the other hand, some segments of the cerebello-thalamo-cortical pathway only showed significant negative relationship with age in FC, but not in FD. Analysis at the tract-level also showed that major fiber tract groups predominantly distributed in the frontal lobe (cingulum, forceps minor) exhibited greater vulnerability to the aging process than the others. Differences in FC and the combined measure of FD and cross section values observed between sexes were mostly driven by differences in brain sizes although male participants tended to exhibit steeper negative linear relationship with age in FD as compared to female participants. Overall, these findings provide further insights into the structural changes the brain's WM undergoes due to the aging process.

    DOI: 10.1002/hbm.25008

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  29. Subsecond EEG-fMRI analysis for presurgical evaluation in focal epilepsy 国際誌

    Ito Yuji, Maesawa Satoshi, Bagarinao Epifanio, Okai Yu, Nakatsubo Daisuke, Yamamoto Hiroyuki, Kidokoro Hiroyuki, Usui Naotaka, Natsume Jun, Hoshiyama Minoru, Wakabayashi Toshihiko, Sobue Gen, Ozaki Norio

    JOURNAL OF NEUROSURGERY   134 巻 ( 4 ) 頁: 1027 - 1036   2020年4月

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    記述言語:日本語   出版者・発行元:Journal of Neurosurgery  

    OBJECTIVE The authors recently reported a novel subsecond analysis method of analyzing EEG–functional MRI (fMRI) to improve the detection rate of epileptic focus. This study aims to validate the utility of this method for presurgical evaluation in pharmacoresistant focal epilepsy. METHODS Among 13 patients with focal epilepsy undergoing presurgical examinations including simultaneous EEG-fMRI at 3T, 11 patients had interictal epileptiform discharges (IEDs) during fMRI. The authors used the sequence of topographic maps during the IEDs as a reference to obtain subsecond fMRI activation maps with the same temporal resolution as the EEG data, and constructed “spike-and-slow-wave-activation-summary” (SSWAS) maps that showed the activation frequency of voxels during IEDs. Clusters were defined by thresholding the SSWAS maps (voxel value > 10), and those containing voxels with the top 3 highest activation frequencies were considered significant. Significant hemodynamic responses using conventional event-related (ER) analysis and SSWAS maps were compared with the resection areas and surgical outcomes at 1 year after surgery. RESULTS Using ER analysis, 4 (36%) of 11 patients had significant hemodynamic responses. One of 4 patients had significant hemodynamic responses in the resection area and good surgical outcome. Using SSWAS maps, 10 (91%) of 11 patients had significant hemodynamic responses. Six of 10 patients had significant hemodynamic responses in the resection area, and 5 of the 6 patients achieved good surgical outcomes. The remaining 4 patients had significant hemodynamic responses distant from the resection area, and only 1 of the 4 patients achieved good surgical outcomes. The sensitivity, specificity, positive predictive value, and negative predictive value of SSWAS maps were 83.3%, 75.0%, 83.3%, and 75.0%, respectively. CONCLUSIONS This study demonstrated the clinical utility of SSWAS maps for presurgical evaluation of pharmacoresistant focal epilepsy. The findings indicated that subsecond EEG-fMRI analysis may help surgeons choose the resection areas that could lead to good surgical outcomes.

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  30. y Distributed source analysis of magnetoencephalography using a volume head model combined with statistical methods improves focus diagnosis in epilepsy surgery 国際誌

    Ishizaki Tomotaka, Maesawa Satoshi, Nakatsubo Daisuke, Yamamoto Hiroyuki, Takai Sou, Shibata Masashi, Kato Sachiko, Natsume Jun, Hoshiyama Minoru, Wakabayashi Toshihiko

    SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁: 5263 - 5263   2020年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Scientific Reports  

    Deep-seated epileptic focus estimation using magnetoencephalography is challenging because of its low signal-to-noise ratio and the ambiguity of current sources estimated by interictal epileptiform discharge (IED). We developed a distributed source (DS) analysis method using a volume head model as the source space of the forward model and standardized low-resolution brain electromagnetic tomography combined with statistical methods (permutation tests between IEDs and baselines and false discovery rate between voxels to reduce variation). We aimed to evaluate the efficacy of the combined DS (cDS) analysis in surgical cases. In total, 19 surgical cases with adult and pediatric focal epilepsy were evaluated. Both cDS and equivalent current dipole (ECD) analyses were performed in all cases. The concordance rates of the two methods with surgically identified epileptic foci were calculated and compared with surgical outcomes. Concordance rates from the cDS analysis were significantly higher than those from the ECD analysis (68.4% vs. 26.3%), especially in cases with deep-seated lesions, such as in the interhemispheric, fronto-temporal base, and mesial temporal structures (81.8% vs. 9.1%). Furthermore, the concordance rate correlated well with surgical outcomes. In conclusion, cDS analysis has better diagnostic performance in focal epilepsy, especially with deep-seated epileptic focus, and potentially leads to good surgical outcomes.

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  31. 手根管開放術前後における脳機能変化

    岩月 克之, 寶珠山 稔, 篠原 孝明, 吉田 彬人, 大山 慎太郎, 米田 英正, 石井 久雄, 栗本 秀, 山本 美知郎, 建部 将広, 平田 仁

    日本整形外科学会雑誌   94 巻 ( 3 ) 頁: S1077 - S1077   2020年3月

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    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

  32. Electroencephalographic Functional Connectivity With the Tacit Learning System Prosthetic Hand: A Case Series Using Motor Imagery

    Iwatsuki Katsuyuki, Hoshiyama Minoru, Oyama Shintaro, Yoneda Hidemasa, Shimoda Shingo, Hirata Hitoshi

    FRONTIERS IN SYNAPTIC NEUROSCIENCE   12 巻   頁: 7   2020年2月

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    出版者・発行元:Frontiers in Synaptic Neuroscience  

    DOI: 10.3389/fnsyn.2020.00007

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  33. Electroencephalographic Functional Connectivity with the Tacit Learning System Prosthetic Hand: a case series using motor imagery 査読有り

    Katsuyuki Iwatsuki, Minoru Hoshiyama, Shintaro Oyama, Hidemasa Yoneda, Shingo Shimoda, Hitoshi Hirata

    Front. Synaptic Neurosci.     2020年2月

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  34. Relationship between upper limb function and functional neural connectivity among motor related-areas during recovery stage after stroke 国際誌

    Hoshino Takashi, Oguchi Kazuyo, Inoue Kenji, Hoshino Aiko, Hoshiyama Minoru

    TOPICS IN STROKE REHABILITATION   27 巻 ( 1 ) 頁: 57 - 66   2020年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Topics in Stroke Rehabilitation  

    Backgrounds: Neural biomarkers to predict motor recovery have been used in the field of rehabilitation. Functional connectivity (FC) among the brain regions recorded by functional magnetic resonance imaging systems have been reported, but convenient method to estimate FC for clinical situation has not been established. Objectives: This observational study investigated the relationship between neural functional connectivity obtained by electroencephalography (EEG) and the upper limb function in patients during recovery stage after stroke. Methods: Twenty-four patients in the recovery stage between 4 and 8 weeks after the onset of stroke (mean age: 62 ± 12 (SD)) were enrolled. The EEG signals were obtained by five electrodes placed on the motor-related areas (C3, C4, FC3, FC4, and FCz in the International 10–20 system) for 60 sec at rest and during finger movement on the affected side, and amplitude envelope correlations as measures of FC among the areas were calculated. Fugl-Meyer Assessment (FMA) was used to assess upper limb motor function. Results: The FMA scores evaluated at 4W (33 ± 24 (SD)) were improved by 8W (42 ± 23) (p <.001). The FCs in α and β bands calculated between the electrodes in the ipsi-lesional hemisphere were correlated negatively with the FMA score at 4W after stroke. The FCs obtained at 4W could be used to predict the FMA score at 8W after stroke. Conclusions: The FCs recorded at rest, as well as during the finger motor task, by the five electrodes placed on motor-related areas could be used to predict the motor function and recovery of the upper limb affected by stroke. The results indicate the possibility of using FCs recorded by conventional EEG with electrodes as biomarkers to predict motor recovery after stroke.

    DOI: 10.1080/10749357.2019.1658429

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  35. FDG-PETとEEG-fMRIを用いててんかん焦点、てんかん性ネットワークの継時的評価を行った結節性硬化症の1例

    牧 祐輝, 伊藤 祐史, 岡井 佑, 白木 杏奈, 川口 将宏, 鈴木 健史, 田中 雅大, 坂口 陽子, 山本 啓之, 中田 智彦, 城所 博之, 前澤 聡, バガリナオ・エピファニオ, 寳珠山 稔, 夏目 淳

    てんかん研究   37 巻 ( 3 ) 頁: 838 - 838   2020年1月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

  36. Disturbance of somatotopic spatial cognition and extra-territorial pain in carpal tunnel syndrome 国際誌

    Yoshida Akihito, Iwatsuki Katsuyuki, Hoshiyama Minoru, Hirata Hitoshi

    NEUROREHABILITATION   46 巻 ( 3 ) 頁: 423 - 431   2020年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NeuroRehabilitation  

    BACKGROUND: Several studies on carpal tunnel syndrome have reported pain that exists beyond the median nerve territory of the affected hand. However, the mechanism is unknown. PURPOSE: We investigated the cause of extra-territorial pain by the analysis of clinical assessments and cortical activity using magnetoencephalography. METHODS: To compare patients with and without extra-territorial pain, fourteen patients with carpal tunnel syndrome were assessed using clinical examination, such as patients' profile, paresthesia, physical tests, and psychological tests. The physical assessment included tactile threshold and static and moving two-point discrimination sensations on digital pulp. Neural activation in the cerebral cortex was also measured using z-scores calculated by magnetoencephalography. RESULTS: Among fourteen patients, ten patients had pain in the affected median nerve territory only and four patients had extra-territorial pain. When comparing the groups, the static and moving two-point discrimination sensation values in patients with extra-territorial pain were larger than those of patients without the pain (p<0.05). The supra-marginal gyrus, mid-part of the precentral sulcus, angular gyrus in the left hemisphere, bilateral sensorimotor areas for legs, and bilateral isthmus-cingulate areas showed larger z-scores in patients with extra-territorial pain than in patients without the pain (p<0.05). CONCLUSIONS: The static and moving two-point discrimination sensations signify the ability of tactile spatial acuity. Bilateral sensorimotor areas were activated in sites that were not the hand. Furthermore, the inferior parietal lobule in the left hemisphere, which synthesizes and integrates multiple sensations showed high activation. Our findings suggested that the mechanism of extra-territorial pain was associated with dysfunction of spatial cognition.

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  37. A magnetoencephalographic study of longitudinal brain function alterations following carpal tunnel release 国際誌

    Iwatsuki Katsuyuki, Hoshiyama Minoru, Yoshida Akihito, Shinohara Takaaki, Hirata Hitoshi

    SCIENTIFIC REPORTS   9 巻 ( 1 ) 頁: 19776 - 19776   2019年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Scientific Reports  

    We investigate changes in brain function before and after carpal tunnel release. Magnetoencephalography (MEG), during which we recorded somatosensory evoked cortical magnetic fields (SEFs), and a clinical evaluation were performed before surgery and 6 months after. The distance on the vertical axis between the equivalent current dipoles (ECDs) for the first and third digits before surgery was significantly less than after surgery. There were no significant differences in values between the control participant and patients after surgery. In terms of distal motor latency, there was a negative correlation with the distance. The recovery function of the root mean square (RMS) before surgery for the N20m was less suppressed at 10 ms of ISI in patients, compared to controls. There were no significant differences in the RMS values for patients before and after surgery. Our results indicate that treating peripheral nerve lesions, such as in carpal tunnel release, positively modifies brain function.

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  38. West症候群におけるてんかんネットワークの継時的変化

    牧 祐輝, 伊藤 祐史, 岡井 佑, 白木 杏奈, 川口 将宏, 鈴木 健史, 田中 雅大, 坂口 陽子, 山本 啓之, 中田 智彦, 城所 博之, 前澤 聡, バガリナオ・エピファニオ, 寶珠山 稔, 夏目 淳

    臨床神経生理学   47 巻 ( 5 ) 頁: 432 - 432   2019年10月

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    記述言語:日本語   出版者・発行元:(一社)日本臨床神経生理学会  

  39. Meaningful occupation: A self-awareness intervention for patients with unilateral spatial neglect 査読有り

    Kaori KAWABATA and Minoru HOSHIYAMA

    New Zealand Journal of Occupational Thearpy     頁: in press   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  40. Action performance in children with autism spectrum disorder at preschool age: A pilot study 査読有り

    Misako Sano, Kaori Yamaguchi, Reiko Fukatsu, Minoru Hoshiyama

    International Journal of Developmental Dissabilities     頁: in press   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  41. Action performance in children with autism spectrum disorder at preschool age: A pilot study 査読有り

    Misako Sano, Kaori Yamaguchi, Reiko Fukatsu, Minoru Hoshiyama

    International Journal of Developmental Dissabilities     頁: in press   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  42. Meaningful occupation: A self-awareness intervention for patients with unilateral spatial neglect 査読有り

    Kaori KAWABATA, Minoru HOSHIYAMA

    New Zealand Journal of Occupational Thearpy     頁: in press   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  43. Reorganization of brain networks and its association with general cognitive performance over the adult lifespan 査読有り 国際誌

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Taoka Toshiaki, Koyama Shuji, Tanabe Hiroki C., Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Ozaki Norio, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Sobue Gen

    SCIENTIFIC REPORTS   9 巻 ( 1 ) 頁: 11352 - 11352   2019年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Scientific Reports  

    Healthy aging is associated with structural and functional changes in the brain even in individuals who are free of neurodegenerative diseases. Using resting state functional magnetic resonance imaging data from a carefully selected cohort of participants, we examined cross sectional changes in the functional organization of several large-scale brain networks over the adult lifespan and its potential association with general cognitive performance. Converging results from multiple analyses at the voxel, node, and network levels showed widespread reorganization of functional brain networks with increasing age. Specifically, the primary processing (visual and sensorimotor) and visuospatial (dorsal attention) networks showed diminished network integrity, while the so-called core neurocognitive (executive control, salience, and default mode) and basal ganglia networks exhibited relatively preserved between-network connections. The visuospatial and precuneus networks also showed significantly more widespread increased connectivity with other networks. Graph analysis suggested that this reorganization progressed towards a more integrated network topology. General cognitive performance, assessed by Addenbrooke’s Cognitive Examination-Revised total score, was positively correlated with between-network connectivity among the core neurocognitive and basal ganglia networks and the integrity of the primary processing and visuospatial networks. Mediation analyses further indicated that the observed association between aging and relative decline in cognitive performance could be mediated by changes in relevant functional connectivity measures. Overall, these findings provided further evidence supporting widespread age-related brain network reorganization and its potential association with general cognitive performance during healthy aging.

    DOI: 10.1038/s41598-019-47922-x

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  44. 筋電義手使用者の人工知能回内外制御に対するニューロリハビリテーション的評価

    岩月 克之, 大山 慎太郎, 寶珠山 稔, 下田 真吾, 栗本 秀, 山本 美知郎, 建部 将広, 平田 仁

    日本手外科学会雑誌   36 巻 ( 1 ) 頁: O53 - 1   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本手外科学会  

  45. Magnetoencephalographic evaluation for the myoelectric hand prosthesis with tacit learning system 国際誌

    Iwatsuki Katsuyuki, Hoshiyama Minoru, Oyama Shintaro, Shimoda Shingo, Hirata Hitoshi

    NEUROREHABILITATION   44 巻 ( 1 ) 頁: 19 - 23   2019年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NeuroRehabilitation  

    BACKGROUND: The effect of tacit learning systems (TLSs) on brain plasticity are as of yet unknown. We developed a myoelectric hand prosthesis equipped with a TLS to auto-regulate forearm rotation in response to upper extremity movement patterns. OBJECTIVE: To evaluate the effects of tacit learning on the central nervous system during a prosthesis control exercise. METHODS: The experienced prosthetic user performed a series of simple mechanical tasks with the TLS inactivated (the baseline condition) and then with it activated (the enhanced, experimental condition). The process was video recorded. Subsequently, the participant viewed video recordings of each condition (baseline and experimental) during magnetoencephalography and electroencephalography recordings. RESULTS: Stronger connections between the motor area and other cortical areas were observed, as indicated by a significant increase in coherence values. CONCLUSIONS: Integration and interoperability may underlie tacit learning and promote motor function-related adaptive neuroplasticity.

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  46. Anatomo-electro-clinical correlations of hypermotor seizures with amygdala enlargement: Hippocampal seizure origin identified using stereoelectroencephalography

    Ishizaki Tomotaka, Maesawa Satoshi, Nakatsubo Daisuke, Yamamoto Hiroyuki, Shibata Masashi, Kato Sachiko, Yoshida Mari, Natsume Jun, Hoshiyama Minoru, Wakabayashi Toshihiko

    EPILEPSY & BEHAVIOR CASE REPORTS   11 巻   頁: 10 - 13   2019年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Epilepsy and Behavior Case Reports  

    DOI: 10.1016/j.ebcr.2018.09.011

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  47. Assessment of attention function recovery in patients after stroke using sequential desk-top tasks

    Tanikaga Miki, Muzuno Jumpei, Tanaka Masahiro, Hoshiyama Minoru

    INTERNATIONAL JOURNAL OF THERAPY AND REHABILITATION   25 巻 ( 12 ) 頁: 665 - 674   2018年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Journal of Therapy and Rehabilitation  

    Background/Aims: The course of recovery of performance with attention function has not been sufficiently investigated during the period for rehabilitation after stroke. A sequential desk-top task was applied, whose performance required the spatiotemporal attention function step by step, to patients after stroke. The relationship between the sequential task and conventional assessments of cognitive function was also assessed. Methods: A sequential desk-top task with 13 levels of peg-carrying performance, which involved attention function, was applied to 24 patients with a disturbance of attention function after stroke. The outcomes of the sequential task were compared with the results of the Mini-Mental State Examination, Trail Making Test Part A and B, Hamamatsu type Japanese syllabary selection test sentence (Syllabary), Paced Auditory Serial Addition Test, Ponsford's Attentional Rating Scale, and Functional Independence Measure. Findings: All participants showed significant progress in the level of the sequential desk-top task. The levels achieved in the sequential task were correlated with the scores of Mini-Mental State Examination, Trail Making Test Part A, Paced Auditory Serial Addition Test, Syllabary, and Functional Independence Measure. Conclusions: The results of the sequential desk-top task suggested the recovery course of the attention function, and the results of the task predicted the functional recovery revealed by other test batteries.

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  48. Brain Activity on Observation of Another Person's Action: A Magnetoencephalographic Study 国際誌

    Mizuno Jumpei, Kawamura Masashi, Hoshiyama Minoru

    MOTOR CONTROL   22 巻 ( 4 ) 頁: 377 - 390   2018年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Motor Control  

    Brain activity was recorded using a whole-head magnetoencephalography system followed by coherence analysis to assess neural connectivity in 10 healthy right-handed adults to clarify differences in neural connectivity in brain regions during action observation from several perspectives. The subjects were instructed to observe and memorize or imitate the hand action from a first-person or second-person visual perspective. The brain activity in coherence was modified among frontal and central, sensorimotor, and mirror neuron system-related regions based on the visual perspectives of finger movements. The regional activity in coherence changed similarly under the imitation and observation tasks compared with the condition of observing static hand figures. The information from different visual perspectives of body movements was processed in the frontal-central regions related to sensorimotor processes and partially in mirror neuron system.

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  49. Use of parametric speaker for older people with dementia in a residential care setting: A preliminary study of two cases

    Nishiura Yuko, Hoshiyama Minoru, Konagaya Yoko

    HONG KONG JOURNAL OF OCCUPATIONAL THERAPY   31 巻 ( 1 ) 頁: 30 - 35   2018年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Hong Kong Journal of Occupational Therapy  

    Objective/Background: Older people with dementia often show behavioural and psychological symptoms of dementia such as agitation, aggression, and depression that affect their activities of daily living, and hence reduce the quality of life of their caregivers. The aim of this study was to investigate the effects of a new technological intervention—a parametric speaker, creating a narrow personal acoustic environment, which may reduce the manifestation of behavioural and psychological symptoms of dementia symptoms. Methods: A parametric speaker was placed on the ceiling of a large day room, and personally selected pieces of music were provided in a narrow space just under the speaker during the intervention. Two older residents with behavioural and psychological symptoms of dementia participated in the experiment. Results: Playing pieces of favorite music via the parametric speaker decreased their behavioural and psychological symptoms of dementia during the intervention. In addition, this intervention reduced the burden on caregivers. One of the advantages of using parametric speaker was being able to create a personal space in a common room. Conclusion: We considered that the parametric speaker might be useful to reduce behavioural and psychological symptoms of dementia and the burden on caregivers, providing individualized rehabilitation for the improved quality of life of residents.

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  50. An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan 国際誌

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Wakabayashi Toshihiko, Kuzuya Masafumi, Ozaki Norio, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Sobue Gen

    NEUROIMAGE   169 巻   頁: 134 - 144   2018年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NeuroImage  

    This study aims to elucidate age-related intrinsic brain volume changes over the adult lifespan using an unbiased data-driven structural brain parcellation. Anatomical brain images from a cohort of 293 healthy volunteers ranging in age from 21 to 86 years were analyzed using independent component analysis (ICA). ICA-based parcellation identified 192 component images, of which 174 (90.6%) showed a significant negative correlation with age and with some components being more vulnerable to aging effects than others. Seven components demonstrated a convex slope with aging; 3 components had an inverted U-shaped trajectory, and 4 had a U-shaped trajectory. Linear combination of 86 components provided reliable prediction of chronological age with a mean absolute prediction error of approximately 7.2 years. Structural co-variation analysis showed strong interhemispheric, short-distance positive correlations and long-distance, inter-lobar negative correlations. Estimated network measures either exhibited a U- or an inverted U-shaped relationship with age, with the vertex occurring at approximately 45–50 years. Overall, these findings could contribute to our knowledge about healthy brain aging and could help provide a framework to distinguish the normal aging processes from that associated with age-related neurodegenerative diseases.

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  51. Detecting sub-second changes in brain activation patterns during interictal epileptic spike using simultaneous EEG-fMRI 国際誌

    Bagarinao Epifanio, Maesawa Satoshi, Ito Yuji, Usui Naotaka, Natsume Jun, Watanabe Hirohisa, Hoshiyama Minoru, Wakabayashi Toshihiko, Sobue Gen, Naganawa Shinji, Isoda Haruo

    CLINICAL NEUROPHYSIOLOGY   129 巻 ( 2 ) 頁: 377 - 389   2018年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical Neurophysiology  

    Objective Epileptic spikes are associated with rapidly changing brain activation involving the epileptic foci and other brain regions in the “epileptic network”. We aim to resolve these activation changes using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) recordings. Methods Simultaneous EEG-fMRI recordings from 9 patients with epilepsy were used in the analysis. Our method employed the whole scalp EEG data to generate regressors for the analysis of fMRI data using the general linear model. Results We were able to resolve, with milliseconds temporal resolution, changes in activation patterns involving suspected epileptic foci and other brain regions in the epileptic network during spike and slow wave. Using summary maps (called SSWAS maps) which show the activation frequency of voxels, we found that suspected epileptic foci tend to be significantly active during this interval. SSWAS maps also enabled the detection of the epileptic foci in 4 of 5 patients where the conventional event-timing-based analysis failed to identify. Conclusion These findings demonstrated the efficacy of the method and the potential application of SSWAS maps to identify epileptic foci. Significance The method could help resolve activation changes during epileptic spike and could provide insights into the underlying pathophysiology of these changes.

    DOI: 10.1016/j.clinph.2017.11.018

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  52. Feed-forward-related neural activity for vocalization: A pilot study using magnetoencephalography

    Kawamura M., Mizuno J., Hoshiyama M.

    Neurology Psychiatry and Brain Research   27 巻   頁: 21 - 26   2018年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Neurology Psychiatry and Brain Research  

    The present pilot study was aimed to clarifying neural activity related with the feed-forward function, sensory-motor integration processed before motor performance. Brain magnetic fields were recorded using a whole-head magnetoencephalography system before vocalization under various levels of surrounding noise in nine healthy volunteers. Participants were instructed to read a word presented on a monitor under auditory conditions with white noise of 60, 80, and 100-dB. The vocal strength of the participants significantly increased with an increase in the intensity of environmental noise. Neural connectivity associated with coherence was calculated among the vocalization-related brain areas selected: truncal area in the primary motor area (M1), premotor area (PM), supplementary motor area (SMA), posterior inferior frontal area (pIF), and posterior part of the superior temporal area (pST). Coherence between M1 and pIF in the frontal cortex without vocalization and auditory pST in the temporal area before vocalization was negatively correlated with the level of environmental noise and vocal strength, respectively. We considered that the findings in this pilot study are, at least partially, relevant to the feed-forward function for vocalization.

    DOI: 10.1016/j.npbr.2017.12.006

    Scopus

  53. 脳腫瘍により症候性West症候群を呈し、脳磁図で焦点が推定された一例

    山本 啓之, 寳珠山 稔, 三宅 未紗, 石丸 聡一郎, 石原 尚子, 前澤 聡, 田中 雅大, 岡井 佑, 坂口 陽子, 大野 敦子, 中田 智彦, 城所 博之, 夏目 淳

    てんかん研究   35 巻 ( 2 ) 頁: 550 - 550   2017年9月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

  54. Association between changes in visual evoked magnetic fields and non-motor features in Parkinson's disease

    Fujisawa Yoshiro, Minato Tomomi, Uemura Jun-ichi, Hoshiyama Minoru, Watanabe Hirohisa, Hirayama Masaaki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   79 巻 ( 2 ) 頁: 147 - 155   2017年5月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya Journal of Medical Science  

    Visual dysfunction can be caused by several abnormalities, including dysfunctions in the visual cortex and retina. Our aim was to investigate changes in visual evoked brain responses in the primary visual cortex associated with Parkinson's disease (PD). Sixteen healthy control subjects and ten patients with PD participated in this study. We assessed the visual evoked magnetic field (VEF) using magnetoencephalography (MEG). Checkerboard pattern reversal (CPR) and monotonous grating pattern (MGP) stimulations were used. Magnetic resonance imaging (MRI) was performed to analyze brain volume and generate a tractogram. Cognitive and olfactory function, and Unified Parkinson's Disease Rating Scale (UPDRS) scores were evaluated in patients with PD. Four components of the VEF (1M, 2M, 3M, 4M) were observed following stimulation. For both stimuli, results from the 1M and 2M components were significantly greater and the latency of the 1M component was increased markedly in the PD group compared with the healthy control group. In the PD group, 1M latency correlated with the UPDRS score of 1 for both stimuli, and a correlation was observed between olfactory function and the UPDRS score of 3 for the CPR stimulation alone. We suggest that the conduction delay observed following visual stimulation occurs peripherally rather than in the primary visual cortex. Degeneration of selective elements of the visual system in the retina, possibly midget cells, may be involved.

    DOI: 10.18999/nagjms.79.2.147

    Web of Science

    Scopus

    PubMed

  55. てんかん脳磁図のdipole distribution解析による焦点、伝播経路診断

    山本 啓之, 寳珠山 稔, 白石 秀明, 岡西 徹, 前澤 聡, 田中 雅大, 坂口 陽子, 岡井 祐, 伊藤 祐史, 大野 敦子, 中田 智彦, 城所 博之, 夏目 淳

    脳と発達   49 巻 ( Suppl. ) 頁: S433 - S433   2017年5月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

  56. Functional inter-cortical connectivity among motor-related cortices during motor imagery: A magnetoencephalographic study

    Obayashi Yota, Uemura Jun-ichi, Hoshiyama Minoru

    SOMATOSENSORY AND MOTOR RESEARCH   34 巻 ( 1 ) 頁: 1 - 8   2017年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Somatosensory and Motor Research  

    Neural connectivity was measured during motor imagery (MI) and motor execution (ME) using magnetoencephalography in nine healthy subjects, MI, and at rest. Lower coherence values during ME and MI between sensorimotor areas than at rest, and lower values during MI between the left supplementary motor area and inferior frontal gyrus than ME suggested the sensorimotor network of MI functioned with similar connectivity to ME and that the inhibitory activity functioned continuously during MI, respectively.

    DOI: 10.1080/08990220.2016.1257985

    Web of Science

    Scopus

    PubMed

  57. The temporal stability and variability across frequency bands in neural synchrony between primary and secondary somatosensory areas following somatosensory stimulation

    Uemura Jun-ichi, Hoshiyama Minoru

    CLINICAL NEUROPHYSIOLOGY PRACTICE   2 巻   頁: 119 - 123   2017年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical Neurophysiology Practice  

    Objectives: To examine the temporal stability and variability of neuronal synchronization among the contralateral primary somatosensory cortex (cSI) and contralateral (cSII) and ipsilateral secondary somatosensory cortex (iSII) in response to median nerve stimulation. Methods: Both the spontaneous magnetoencephalography (MEG) signals as the pre-stimulus condition and somatosensory evoked magnetic-fields (SEF) were recorded in eleven healthy subjects. We calculated a phase-locking value (PLV) between two areas among cSI, cSII, and iSII in five frequency bands (theta: 5–7 Hz, alpha: 8–12 Hz, beta: 15–29 Hz, gamma-1: 30–59 Hz, and gamma-2: 60–90 Hz), and compared the PLV among in pre-stimulus and stimulus conditions. Results: The PLV between cSI and cSII for the theta band activity varied within 2 s from the stimulus onset. On the other hand, the PLV between cSI and iSII for the alpha band did not vary within 2 s. Conclusion: The fluctuation of neuronal synchrony among sensory-related cortices in response to median nerve stimulation depends on the induced frequency band and inter-region. Significance: This study is the first to report the temporal characteristic of stimulus-driven neural synchrony following somatosensory stimulation.

    DOI: 10.1016/j.cnp.2017.05.002

    Web of Science

    Scopus

    PubMed

  58. Neuroscientific evidence for multisensory convergence and interaction 招待有り

    Tanaka E, Kida T, Kakigi R, Hoshiyama M

    The Journal of Physical Fitness and Sports Medicine   6 巻 ( 5 ) 頁: 301 - 310   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:一般社団法人日本体力医学会  

    <p>Effective behaviors optimized for various situations are enabled by various sensory information. How does the brain deal simultaneously with information from different sensory systems? Investigation of multisensory processing began from neuroanatomical and neurophysiological studies at the level of single neurons. Accumulation of knowledge concerning neurons and progress in recording techniques of human brain activity have led to a massive expansion in recent neuroscientific studies using various combinations of brain activity recording and cognitive tasks. In this paper, we briefly review recent neuroscientific studies related to multisensory convergence and interaction, focusing on electrophysiological and imaging studies in humans.</p>

    DOI: 10.7600/jpfsm.6.301

    CiNii Research

  59. Visual function assessment in stroke patients using a dynamic three-dimensional visual tasks 査読有り

    Suzuki Megumi, Hoshiyama Minoru, Yamada Masayuki, Maeda Akiko, Saitoh Eiichi

    Fujita Medical Journal   3 巻 ( 3 ) 頁: 67 - 71   2017年

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    記述言語:英語   出版者・発行元:藤田学園医学会  

    <p><b>Objectives:</b> Patients with right-hemisphere brain lesions often show unilateral neglect, which causes various difficulties in their daily lives. Disturbances in visuospatial cognition, including unilateral neglect, can be tested quantitatively using questionnaires, yet visuospatial cognition is related not only to the visual system, but also to other cognitive and behavioral functions. Such functions should be assessed by integrative visuo-cognitive tasks. Therefore, the objective of the present study was to clarify visual disturbances in patients with brain lesions using multi-modal visual function tests including three-dimensional and dynamic visual tasks.</p><p><b>Methods:</b> We recruited 29 patients, 14 with right- and 15 with left-hemispheric brain lesions, and age-matched control subjects. We conducted depth perception tests and static and active motion detection tests to clarify subjects' three-dimensional visual recognition performance.</p><p><b>Results:</b> There were no significant differences between the patients and controls on any of the visual function tests, except for the static detection test with a mosaic background. However, patients' total scores on the visual function tests were lower than those of the controls.</p><p><b>Discussion:</b> The observed decline in total visual function scores suggests that visual dysfunction caused by stroke should be evaluated not by a single visual function test, but by a series of such tests. We propose that visual functioning in daily life should be evaluated using multi-modal visual function tests.</p>

    DOI: 10.20407/fmj.3.3_67

    CiNii Research

  60. Biomechanical Reconstruction Using the Tacit Learning System: Intuitive Control of Prosthetic Hand Rotation 査読有り

    Shintaro Oyama,Shingo Shimoda,Fady SK Alnajjar,Katsuyuki Iwatsuki,Minoru Hoshiyama,Hirotaka Tanaka,Hitoshi Hirata

    Frontiers in Neurorobotics   00 巻 ( 00 ) 頁: in press   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  61. Distinctive distribution of brain volume reductions in MELAS and mitochondrial DNA A3243G mutation carriers: A voxel-based morphometric study. 査読有り

    Tsujikawa K, Senda J, Yasui K, Hasegawa Y, Hoshiyama M, Katsuno M, Sobue G.

    Mitochondrion   30 巻   頁: 229-235   2016年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  62. Recovery function of somatosensory evoked brain response in patients with carpal tunnel syndrome: A magnetoencephalographic study. 査読有り

    Iwatsuki K, Yoshida A, Shinohara T, Nakano T, Uemura J, Goto S, Hirayama M, Hoshiyama M, Hirata H.

    Clin Neurophysiol   127 巻 ( 8 ) 頁: 2733-2738   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  63. Disinhibitory shift of recovery curve of somatosensory-evoked response in elderly: A magnetoencephalographic study. 査読有り

    Goto S, Fujisawa Y, Uemura J, Yamada S, HOSHIYAMA M, Hirayama M.

    Clinical Neurophysiology   126 巻 ( 6 ) 頁: 1228-1233   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.clinph.2014.09.018

  64. Effect of Cognitive Load on Seating Posture in Children. 査読有り

    Igarashi Go, Karashima Chieko, HOSHIYAMA Minoru

    Occupational Thererapy International     2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/oti.1405

  65. Compensatory postural sway while seated posture during tasks in children with autism spectrum disorder. 査読有り

    FUNAHASHI Yoshimi, KARASHIMA Chieko, HOSHIYAMA Minoru

    Occupational Thererapy International   21 巻 ( 4 ) 頁: 166-175   2014年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/oti.1375

  66. Effectiveness of midazolam for L-arginine-resistant headaches during stroke-like episodes in MELAS: a case report. 査読有り

    Tsujikawa K, Yokoi S, Yasui K, Hasegawa Y, HOSHIYAMA M, Yanagi T.

    Rinsho Shinkeigaku   2014 巻 ( 54 ) 頁: 882-887   2014年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  67. Behavioral and physiological observation during the daytime: How patients with advanced dementia spend the time in a care facility. 査読有り

    YAMAGUCHI Kaori, HOSHIYAMA Minoru

    Asian J Occup Ther     頁: in press   2013年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  68. Effects of emotional music on visual processes in inferior temporal area. 査読有り

    JOMORI Izumi, HOSHIYAMA Minoru, UEMURA Jun-ichi, NAKAGAWA Yoshiro, HOSHINO Aiko, IWAMOTO Yuko.

    Cognitive Neuroscience   4 巻 ( 1 ) 頁: 21-30   2013年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  69. Time orientation during the day in the elderly with dementia. 査読有り

    IWAMOTO Yuko, HOSHIYAMA Minoru.

    Physical and Occupational Therapy in Geriatrics     頁: in press   2012年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  70. Auditory mismatch response modified by visual stimulation accompanied with auditory stimulation. 査読有り

    NAKAGAWA Yoshiro, HOSHIYAMA Minoru, UEMURA Jun-ichi, JOMORI Izumi

    Neurophysiology   44 巻 ( 3 ) 頁: in press   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  71. Virbroarthrography in patients with knee arthropathy. 査読有り

    TANAKA Noriyuki, HOSHIYAMA Minoru

    J Back Musculoskelet Rehab   in press 巻   頁: 000-001   2012年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  72. Articular sound and clinical stages in knee arthropathy. 査読有り

    TANAKA Noriyuki, HOSHIYAMA Minoru

    J Musculoskelet Res   14 巻 ( 1 ) 頁: 1-9   2012年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: DOI: 10.1142/S021895771500060

  73. Kinematic analysis of sit to stand by persons with rheumatoid arthritis supported by a service dog. 査読有り

    NOGUCHI Hiromi, TAGAWA Yoshikatsu, HOSHIYAMA Minoru

    Disab Rehab Assist Tech   7 巻 ( 1 ) 頁: 45-54   2012年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  74. Alteration of time perception in young and elderly people during jigsaw puzzle tasks with different complexities. 査読有り

    IWAMOTO Yuko, HOSHIYAMA Minoru, TAGAWA Yoshikatsu

    Occup Ther Int   18 巻   頁: 194-200   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  75. Difference in P300 response between hemi-field visual stimulation 査読有り

    SUZUKI Megumi, HOSHIYIAMA Minoru

    Neurol Sci   32 巻   頁: 603-308   2011年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  76. Biological observation during the daytime of elderly patients with advanced dementia cared for with and without artificial nutrition by percutaneous endoscopic gastrostomy (PEG). 査読有り

    YAMAGUCHI Kaori, HOSHIYAMA Minoru, TAKANO Masanori

    Geriat Geron Int   11 巻 ( 2 ) 頁: 221-228   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  77. An integration of color and motion information in visual scene analyses.

    NOGUCHI Yasuyuki, KAKIGI Ryusuke, HOSHIYAMA Minoru

    Psychol Sci   22 巻 ( 2 ) 頁: 153-158   2011年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  78. Frontal activity during imagination of rhythm: An event-related potential study. 査読有り

    JOMORI Izumi, UEMURA Jun-Ichi, NAKAGAWA Yoshiro, HOSHIYAMA Minoru

    J Clin Neurosci     頁: in press   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  79. Kinematic analysis of seating maneuver: Digitalization of movement in daily living. 査読有り

    TAKEI Maki, SHIMIZU Hideki, HOSHIYAMA Minoru.

    Hum Mov   11 巻 ( 2 ) 頁: 114-118   2010年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  80. Effect of task-irrelevant high-speed verbal stimulation on a visual/verbal word-discrimination task: An event-related potential study. 査読有り

    UEMURA Jun-Ichi, HOSHIYAMA Minoru.

    Clin Neurophysiol   121 巻 ( 12 ) 頁: 2065-2069   2010年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  81. Does self-efficacy to falls in hip-protector users affect quality of life (QOL) and physical activity in nursing homes in Japan? 査読有り

    KATO Chikako, IDA Kunio, HOSHIYAMA Minoru, HARADA Atsushi

    J Am Geriat Soc   58 巻 ( 9 ) 頁: 1810-1812   2010年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  82. *Effects of music therapy on involuntary swallowing. 査読有り

    Jomori I, Hoshiyama M.

    Nord J Music Ther.   19 巻 ( 1 ) 頁: 51-62   2010年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  83. *Auditory brain response modified by temporal deviation of language rhythm: an auditory event-related potential study. 査読有り

    Jomori I, Hoshiyama M.

    Neurosci Res   65 巻 ( 2 ) 頁: 187-193   2009年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  84. The characteristics of no-go potentials with intraepidermal stimulation. 査読有り

    Nakata H, Sakamoto K, Inui K, Hoshiyama M, Kakigi R.

    Neuroreport   20 巻 ( 13 ) 頁: 1149-1154   2009年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  85. *Attention deficits of patients with chronic-stage traumatic brain injury: a behavioral study involving a dual visuo-spatial task. 査読有り

    Hasegawa J, Hoshiyama M.

    J Clin Exp Neuropsychol   31 巻 ( 3 ) 頁: 1227-1237   2009年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  86. Centrifugal modulation of human LEP components to a task-relevant noxious stimulation triggering voluntary movement. 査読有り

    Nakata H, Sakamoto K, Honda Y, Mochizuki H, Hoshiyama M, Kakigi R.

    Neuroimage   45 巻 ( 1 ) 頁: 129-142   2009年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  87. Event-related potentials for gender discrimination: an examination between differences in gender discrimination between males and females. 査読有り

    Suyama N, Hoshiyama M, Shimizu H, Saito H.

    Int J Neurosci.   118 巻 ( 9 ) 頁: 1227-1237   2008年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  88. Evoked magnetic fields following noxious laser stimulation of the thigh in humans. 査読有り

    LinksNakata H, Tamura Y, Sakamoto K, Akatsuka K, Hirai M, Inui K, Hoshiyama M, Saitoh Y, Yamamoto T, Katayama Y, Kakigi R.

    Neuroimage   42 巻 ( 2 ) 頁: 858-868   2008年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  89. *Temporal dynamics of adaptation to natural sounds in the human auditory cortex. 査読有り

    Altmann CF, Nakata H, Noguchi Y, Inui K, Hoshiyama M, Kaneoke Y, Kakigi R.

    Cereb Cortex   18 巻 ( 6 ) 頁: 1350-1360   2008年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  90. Spatial contexts can inhibit a mislocalization of visual stimuli during smooth pursuit. 査読有り

    Noguchi Y, Shimojo S, Kakigi R, Hoshiyama M.

    J Vis   7 巻 ( 13 ) 頁: 1-15   2007年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  91. Objective examination for two-point stimulation using a somatosensory oddball paradigm: an MEG study. 査読有り

    Akatsuka K, Wasaka T, Nakata H, Kida T, Hoshiyama M, Tamura Y, Kakigi R.

    Clin Neurophysiol.     頁: 118(2):403-11.   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  92. Voluntary attention changes the speed of perceptual neural processing. 査読有り

    Noguchi Y, Tanabe HC, Sadato N, Hoshiyama M, Kakigi R.

    Eur J Neurosci.     頁: 25(10):3163-72   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  93. *Variability of P300 in elderly patients with dementia during a single day. 査読有り

    Uemura J, Hoshiyama M.

    Int J Rehabil Res.     頁: 30(2):167-70.   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  94. Priority of repetitive adaptation to mismatch response following undiscriminable auditory stimulation: a magnetoencephalographic study. 査読有り

    Hoshiyama M, Okamoto H, Kakigi R.

    Eur J Neurosci.     頁: 25(3):854-62.   2007年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  95. Backward-masking: the effect of the duration of the second stimulus on recognition of the first stimulus. 査読有り

    Hashimoto A, Watanabe S, Inui K, Hoshiyama M, Murase S, Kakigi R.

    Neuroscience.     頁: 137(4):1427-37   2006年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  96. 意識閾値以下の顔刺激による脳反応

    寳珠山 稔, 柿木隆介

    臨床脳波     頁: 48(8) : 468-473   2006年

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    記述言語:日本語  

  97. 発声時の聴覚誘発反応

    軍司敦子, 柿木隆介, 宝珠山 稔

    臨床脳波     頁: 48(6) : 355-359   2006年

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    記述言語:日本語  

  98. Functional changes in cortical components of somatosensory evoked responses by stimulus repetition. 査読有り

    Hoshiyama M, Kakigi R.

    Clin Neurophysiol.     頁: S59:149-57.   2006年

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  99. Priority of face perception during subliminal stimulation using a new color-opponent flicker stimulation. 査読有り

    Hoshiyama M, Kakigi R, Takeshima Y, Miki K, Watanabe S.

    Neurosci Lett.     頁: 402(1-2):57-61.   2006年

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  100. Cognitive mechanism for meaning of emotive words in depressed personality: an event-related potential study. 査読有り

    Shimizu H, Saito H, Hoshiyama M.

    Nagoya J Med Sci.     頁: 68(1-2):35-44.   2006年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  101. Characteristics of processing for trait adjectives in depressive persons: an event-related potential study. 査読有り

    Shimizu H, Saito H, Hoshiyama M.

    Nagoya J Med Sci.     頁: 68(1-2):27-33.   2006年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  102. Differential priming effects of color-opponent subliminal stimulation on visual magnetic responses. 査読有り

    Hoshiyama M, Kakigi R, Takeshima Y, Miki K, Watanabe S.

    Hum Brain Mapp.     頁: 27(10):811-8.   2006年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  103. Functional relationship between human rolandic oscillations and motor cortical excitability: an MEG study. 査読有り

    Tamura Y, Hoshiyama M, Nakata H, Hiroe N, Inui K, Kaneoke Y, Inoue K, Kakigi R.

    Eur J Neurosci.     頁: 21(9):2555-62.   2005年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  104. 微小磁場計測装置を用いた末梢神経活動磁場の計測

    寳珠山稔, 柿木隆介

    臨床脳波     頁: 47(4) : 215-220   2005年

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    記述言語:日本語  

  105. Mismatch responses related to temporal discrimination of somatosensory stimulation. 査読有り

    Akatsuka K, Wasaka T, Nakata H, Inui K, Hoshiyama M, Kakigi R.

    Clin Neurophysiol.     頁: 116(8):1930-7.   2005年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  106. Face representation in the human secondary somatosensory cortex. 査読有り

    Nguyen BT, Inui K, Hoshiyama M, Nakata H, Kakigi R.

    Clin Neurophysiol.     頁: 116(6):1247-53.   2005年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  107. 調音をともなう発声時のヒト脳磁場反応

    軍司敦子, 柿木隆介, 宝珠山稔

    臨床脳波     頁: 46(8) : 487-491   2004年

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    記述言語:日本語  

  108. Facilitation of A[delta]-fiber-mediated acute pain by repetitive transcranial magnetic stimulation. 査読有り

    Tamura Y, Hoshiyama M, Inui K, Nakata H, Qiu Y, Ugawa Y, Inoue K, Kakigi R.

    Neurology.     頁: 62(12):2176-81.   2004年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  109. Temporal discrimination threshold on various parts of the body. 査読有り

    Hoshiyama M, Kakigi R, Tamura Y.

    Muscle Nerve.     頁: 29(2):243-7.   2004年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  110. Cognitive processes in two-point discrimination: an ERP study. 査読有り

    Tamura Y, Hoshiyama M, Inui K, Nakata H, Wasaka T, Ojima S, Inoue K, Kakigi R.

    Clin Neurophysiol.     頁: 115(8):1875-84.   2004年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  111. 正中神経刺激による体性感覚誘発電位のRecovery function-短時間Interstimulus intervalでの検討-

    宝珠山稔, 柿木隆介

    臨床脳波     頁: 46(7) : 424-429   2004年

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    記述言語:日本語  

  112. Human brain processing and central mechanisms of pain as observed by electro- and magneto-encephalography. 査読有り

    Kakigi R, Inui K, Tran DT, Qiu Y, Wang X, Watanabe S, Hoshiyama M.

    J Chin Med Assoc.     頁: 67(8):377-86   2004年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  113. Face representation in the human primary somatosensory cortex. 査読有り

    Nguyen BT, Tran TD, Hoshiyama M, Inui K, Kakigi R.

    Neurosci Res.     頁: 50(2):227-32.   2004年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  114. 自己発声音に対する聴覚反応

    軍司敦子, 柿木隆介, 宝珠山稔

    日本生体磁気学会誌     頁: 16(1) : 34-35   2003年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  115. Changes in somatosensory evoked responses by repetition of the median nerve stimulation. 査読有り

    Hoshiyama M, Kakigi R.

    Clin Neurophysiol.     頁: 114(12):2251-7.   2003年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  116. Gating of somatosensory evoked magnetic fields during the preparatory period of self-initiated finger movement. 査読有り

    Wasaka T, Hoshiyama M, Nakata H, Nishihira Y, Kakigi R.

    Neuroimage.     頁: 20(3):1830-8   2003年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  117. Sensory perception during sleep in humans: a magnetoencephalograhic study. 査読有り

    Kakigi R, Naka D, Okusa T, Wang X, Inui K, Qiu Y, Tran TD, Miki K, Tamura Y, Nguyen TB, Watanabe S, Hoshiyama M.

    Sleep Med.     頁: 4(6):493-507   2003年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  118. Effect of tactile interference stimulation of the ear in human primary somatosensory cortex: a magnetoencephalographic study. 査読有り

    Nihashi T, Kakigi R, Hoshiyama M, Miki K, Kajita Y, Yoshida J, Yatsuya H.

    Clin Neurophysiol.     頁: 114(10):1866-78.   2003年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  119. Electrical-induced pain diminishes somatosensory evoked magnetic cortical fields. 査読有り

    Tran TD, Hoshiyama M, Inui K, Kakigi R.

    Clin Neurophysiol     頁: 114(9):1704-14   2003年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  120. Cortical activities relating to modulation of sound frequency: how to vocalize? 査読有り

    Gunji A, Kakigi R, Hoshiyama M. Related Articles, Links

    Brain Res Cogn Brain Res.     頁: 17(2):495-506   2003年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  121. Effects of sleep on pain-related somatosensory evoked magnetic fields in humans. 査読有り

    Wang X, Inui K, Qiu Y, Hoshiyama M, Tran TD, Nguyen TB, Kakigi R.

    Brain Res Cogn Brain Res     頁: 17(2):388-99   2003年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  122. Brain responses for the subconscious recognition of faces. 査読有り

    Hoshiyama M, Kakigi R, Watanabe S, Miki K, Takeshima Y.

    Neurosci Res     頁: 46(4):435-42   2003年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  123. A comparative magnetoencephalographic study of cortical activations evoked by noxious and innocuous somatosensory stimulations. 査読有り

    Inui K, Tran TD, Qiu Y, Wang X, Hoshiyama M, Kakigi R.

    Neuroscience.     頁: 120(1):235-48   2003年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  124. Central mechanisms for two-point discrimination in humans. 査読有り

    Tamura Y, Hoshiyama M, Inui K, Kakigi R.

    Neurosci Lett.     頁: 342(3):187-90   2003年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  125. Cerebral responses following stimulation of unmyelinated C-fibers in humans: electro- and magneto-encephalographic study. 査読有り

    Kakigi R, Tran TD, Qiu Y, Wang X, Nguyen TB, Inui K, Watanabe S, Hoshiyama M.

    Neurosci Res     頁: 45(3):255-75   2003年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  126. Effects of sleep on pain-related somatosensory evoked potentials in humans. 査読有り

    Wang X, Inui K, Qiu Y, Hoshiyama M, Tran TD, Kakigi R.

    Neurosci Res.     頁: 45(1):53-7   2003年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  127. 聴覚系高次脳機能の脳磁図

    宝珠山稔, 柿木隆介

    臨床脳波     頁: 45(6) : 359-364   2003年

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    記述言語:日本語  

  128. 着脱可能な乗用車(タクシー)用移乗補助椅子の開発とその有効性

    原和子, 宝珠山稔, 渡辺崇史

    作業療法     頁: 22 : 5600   2003年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  129. 痛覚関連体性感覚誘発脳磁場に対する睡眠の影響

    王暁宏, 乾幸二, 秋雲海, 宝珠山稔, Tuan Diep Tran, 柿木隆介

    日本生体磁気学会誌     頁: 15(1) : 159-160   2002年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  130. Cerebral activation by the signals ascending through unmyelinated C-fibers in humans: a magnetoencephalographic study. 査読有り

    Tran TD, Inui K, Hoshiyama M, Lam K, Qiu Y, Kakigi R.

    Neuroscience     頁: 113(2):375-86   2002年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  131. 痛覚認知機能の生理学的研究

    柿木隆介, 乾幸二, 宝珠山稔, 渡辺昌子, Tran Diep Tuan, 秋云海, 王暁宏

    麻酔     頁: 51 : 5115-5124   2002年

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    記述言語:日本語  

  132. 正中神経刺激による短潜時体性感覚誘発脳磁界と脳電位の対応

    宝珠山稔, 柿木隆介

    臨床脳波     頁: 44(2) : 91-96   2002年

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    担当区分:筆頭著者   記述言語:日本語  

  133. 痛覚関連脳冒位と皮膚刺激領域との関連について 査読有り

    堀内万起子, 猪田邦雄, 宝珠山稔

    理学療法の医学的基礎     頁: 6(1) : 24   2002年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  134. 表皮内電気刺激法による痛覚関連誘発脳磁場

    乾幸二, Tuan Diep Tran, 秋雲海, 王暁宏, 宝珠山稔, 柿木隆介

    日本生体磁気学会誌     頁: 15(1) : 101-102   2002年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  135. Conduction velocity of the spinothalamic tract following CO2 laser stimulation of C-fibers in humans. 査読有り

    Tran TD, Inui K, Hoshiyama M, Lam K, Kakigi R.

    Pain     頁: 95(1-2):125-31.   2002年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  136. Preferential stimulation of Adelta fibers by intra-epidermal needle electrode in humans. 査読有り

    Inui K, Tran TD, Hoshiyama M, Kakigi R.

    Pain     頁: 96(3):247-52   2002年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  137. New concept for the recovery function of short-latency somatosensory evoked cortical potentials following median nerve stimulation. 査読有り

    Hoshiyama M, Kakigi R.

    Clin Neurophysiol.     頁: 113(4):535-41.   2002年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  138. Pain-related magnetic fields evoked by intra-epidermal electrical stimulation in humans. 査読有り

    Inui K, Tran TD, Qiu Y, Wang X, Hoshiyama M, Kakigi R.

    Clin Neurophysiol.     頁: 113(2):298-304.   2002年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  139. 音想起に関する脳内活動の脳磁場解析

    宝珠山稔、軍司敦子, 柿木隆介

    日本生体磁気学会誌     頁: 14(1) : 96-97   2001年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  140. 耳の第一次体性感覚野における受容野の検討

    二橋尚志, 柿木隆介, 宝珠山稔, 梶田泰一, 吉田純

    臨床脳波     頁: 43(9) : 577-582   2001年

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    記述言語:日本語  

  141. Representation of the ear in human primary somatosensory cortex. 査読有り

    Nihashi T, Kakigi R, Kawakami O, Hoshiyama M, Itomi K, Nakanishi H, Kajita Y, Inao S, Yoshida J.

    Neuroimage.     頁: 13(2):295-304.   2001年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  142. A unique area of the homonculus: the topography of the primary somatosensory cortex in humans following posterior scalp and shoulder stimulation. 査読有り

    Itomi K, Kakigi R, Hoshiyama M, Watanabe K.

    Brain Topogr     頁: 14(1):15-23.   2001年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  143. Effects of attention on pattern-reversal visual evoked potentials: foveal field stimulation versus peripheral field stimulation. 査読有り

    Hoshiyama M, Kakigi R.

    Brain Topogr.     頁: 13(4):293-8   2001年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  144. Two evoked responses with different recovery functions in the primary somatosensory cortex in humans. 査読有り

    Hoshiyama M, Kakigi R.

    Clin Neurophysiol.     頁: 112(7):1334-42   2001年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  145. Neural activities during Wisconsin Card Sorting Test--MEG observation. 査読有り

    Wang L, Kakigi R, Hoshiyama M.

    Brain Res Cogn Brain Res     頁: 12(1):19-31.   2001年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  146. Correspondence between short-latency somatosensory evoked brain potentials and cortical magnetic fields following median nerve stimulation. 査読有り

    Hoshiyama M, Kakigi R.

    Brain Res.     頁: 908(2):140-8.   2001年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  147. Hearing the sound of silence: a magnetoencephalographic study. 査読有り

    Hoshiyama M, Gunji A, Kakigi R.

    Neuroreport     頁: 12(6):1097-102   2001年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  148. A new method for measuring the conduction velocities of Abeta-, Adelta- and C-fibers following electric and CO(2) laser stimulation in humans.. 2001 Apr 6; 査読有り

    Tran TD, Lam K, Hoshiyama M, Kakigi R.

    Neurosci Lett     頁: 301(3):187-90.   2001年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  149. Auditory response following vocalization: a magnetoencephalographic study. 査読有り

    Gunji A, Hoshiyama M, Kakigi R.

    Clin Neurophysiol     頁: 112(3):514-20.   2001年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  150. 聴覚マスキング条件下の発声関連脳磁場

    軍司敦子, 宝珠山稔, 柿木隆介

    日本生体磁気学会誌     頁: 13(1) : 222-223   2000年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  151. Transcutaneous electrical nerve stimulation(TENS)後の痛覚関連脳反応の変化

    柿木隆介,宝珠山稔

    PAIN RESEARCH     頁: 15(3) : 155   2000年

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    記述言語:日本語  

  152. 耳電気刺激による体性感覚誘発脳磁界反応

    二橋尚志, 柿木隆介, 川上治, 宝珠山稔, 梶田泰一, 稲尾意秀, 吉田純

    日本生体磁気学会誌     頁: 13(1) : 182-183   2000年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  153. 後頚部、肩部の体性感覚誘発脳磁図

    糸見和也, 柿木隆介, 宝珠山稔

    日本生体磁気学会誌     頁: 13(1) : 184-185   2000年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  154. Identification of auditory evoked potentials of one's own voice. 査読有り

    Gunji A, Hoshiyama M, Kakigi R.

    Clinical Neurophysiology     頁: 111,2,214-219   2000年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  155. Vibratory stimulation of proximal muscles does not affect cortical components of somatosensory evoked potential following distal nerve stimulation. 査読有り

        頁: 111(9):1607-10   2000年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  156. Effects of check size on pattern reversal visual evoked magnetic field and potential. 査読有り

    Nakamura M, Kakigi R, Okusa T, Hoshiyama M, Watanabe K.

    Brain Res     頁: 28;872(1-2):77-86.   2000年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  157. The somatosensory evoked magnetic fields. 査読有り

    Kakigi R, Hoshiyama M, Shimojo M, Naka D, Yamasaki H, Watanabe S, Xiang J, Maeda K, Lam K, Itomi K, Nakamura A.

    Prog Neurobiol     頁: 61(5):495-523   2000年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  158. Effects of distraction on pain-related somatosensory evoked magnetic fields and potentials following painful electrical stimulation. 査読有り

    Yamasaki H, Kakigi R, Watanabe S, Hoshiyama M.

    Brain Res Cogn Brain Res     頁: 9(2):165-75.   2000年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  159. Spatiotemporal source analysis of vocalization-associated magnetic fields. 査読有り

    Gunji A, Kakigi R, Hoshiyama M.

    Brain Res Cogn Brain Res     頁: 9,2,157-163   2000年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  160. After-effect of transcutaneous electrical nerve stimulation (TENS) on pain-related evoked potentials and magnetic fields in normal subjects. 査読有り

    Hoshiyama M, Kakigi R.

    Clinical Neurophysiology     頁: 111,4,717-724   2000年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  161. Dermatome versus homunculus; detailed topography of the primary somatosensory cortex following trunk stimulation. 査読有り

    Itomi K, Kakigi R, Maeda K, Hoshiyama M.

    Clinical Neurophysiology     頁: 111,3,405-12   2000年

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  162. 電気刺激による痛覚関連脳磁場に対する注意効果

    山崎浩, 柿木隆介, 宝珠山稔

    日本生体磁気学会誌     頁: 12(1) : 42-43   1999年

     詳細を見る

    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  163. 随伴陰性変動課題におけるcortical silent periodの変化

    宝珠山稔,柿木隆介

    臨床脳波     頁: 41(11) : 713-717   1999年

     詳細を見る

    記述言語:日本語  

  164. Peripheral nerve conduction study by small multi-channel gradiometers(micro-SQUID).

    Neuroscience Letters   272 巻   頁: 199-202   1999年

     詳細を見る

    記述言語:英語  

  165. Topography of the secondary somatosensory cortex in humans: a magnetoencephalo-graphic study.Neuroreport. 査読有り

    NeuroReport   10 巻 ( 2 ) 頁: 301-306   1999年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  166. Structure of the auditory evoked magnetic fields during sleep. 査読有り

    Neuroscience   93 巻 ( 2 ) 頁: 573-783   1999年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  167. Shortening of the cortical silent period following transcranial wagnetic brain stimulation during an experimental paradigm for generating contingent negative variation(CNV).

    Electroencephalography and Clinical Neurophysiology   110 巻   頁: 1394-1398   1999年

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    記述言語:英語  

  168. Changes of somatoseusory evoked potentials(SEP)during writing with dominant and non-aominant hands.

    Brain Research   833 巻   頁: 10-19   1999年

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    記述言語:英語  

  169. Pain processing traced by magnetoencephalography in the human brain.

    Brain Topography   10 巻   頁: 255-246   1998年

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    記述言語:英語  

  170. Visual evoked magnetic responses to central and peripheral stimulation : simultaneous VEP recordings.

    Brain topography   10 巻   頁: 227-237   1998年

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    記述言語:英語  

  171. Changes of somatosensory evoked potentials preceding rapid voluntary movement in GO/No-go choice reaction time task.

    Brain Research, Cognitive Brain Research   7 巻   頁: 137-142   1998年

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    記述言語:英語  

  172. Reading of Japanese Kanji (morphograms) and Kana (syllabogram) : a magnetoencephalographic study.

    Neuropsychologica   36 巻   頁: 83-98   1998年

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    記述言語:英語  

  173. Somatosensory evoked magnetic fields following passive finger movement.

    Brain Research, Cognitive brain research   6 巻   頁: 73-82   1997年

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    記述言語:英語  

  174. Temporal changes of pyramidal tract activities after decision of movement : a study using transcranial magnetic stimulation of the motor cortex in humans.

    Electroencephalography and Clinical Neurophysiology   105 巻   頁: 255-261   1997年

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    記述言語:英語  

  175. Effects of movement and movement imagery on somatosensory evoked magnetic fields following posterior tibial nerve stimulation.

    Brain Research, Cognitive brain Research   5 巻   頁: 241-253   1997年

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    記述言語:英語  

  176. Magnetoencephalographic study of intracerebral interactions caused by bilateral posterior tibial nerve stimulation in man.

    Neuroscience Research   28 巻   頁: 41-47   1997年

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    記述言語:英語  

  177. Smoatosensory magnetic fields and potentials following passive toe movement in humans.

    Electroencephalography and Clinical Neurophysiology   104 巻   頁: 393-401   1997年

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    記述言語:英語  

  178. Activity in posterior parietal cortex following somatosensory stimulation in man : magnetoencephalographic study using spatio-temporal source analysis.

    Brain Topography   10 巻   頁: 23-30   1997年

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    記述言語:英語  

  179. Identification of motor and sensory brain actiivities during unilateral finger movement : spatio-temporal source analysis of movement-associated magnetic fields.

    Experimental Brain Research   115 巻   頁: 6-14   1997年

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    記述言語:英語  

  180. Odorant evoked magnetic fields in humans.

    Neuroscience Research   27 巻   頁: 115-122   1997年

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    記述言語:英語  

  181. Visual evoked cortical magnetic fields to pattern reversal stimulation.

    Brain Research, Cognitive Brain Research   6 巻   頁: 9-22   1997年

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    記述言語:英語  

  182. ヒトの痛覚認知に及ぼす侵害的冷覚刺激の影響

    渡邊昌子,柿木隆介,宝珠山稔,北村吉宏,小山幸子,下条素子

    臨床脳波     頁: 38(10) : 679-685,   1996年

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    記述言語:英語  

  183. 生理学的手法(脳磁図・脳波)を用いたヒト脳機能の非侵襲的研究

    柿木隆介,宝珠山稔,小山幸子,北村吉宏,下条素子,渡邊昌子

    インナービジョン     頁: 11(8) : 24,   1996年

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    記述言語:日本語  

  184. Differentiation of receptive fields in the sensory cortex following various areas of the lower limb in humans : a magnetoencephalographic study.

    Journal of Neurosurgery   85 巻   頁: 255-262   1996年

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    記述言語:英語  

  185. Effects of noxious cooling of the skin on pain perception in man.

    Journal of Neurological Sciences   135 巻   頁: 68-73   1996年

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    記述言語:英語  

  186. Somatosensory evoked magnetic fields following stimulation of the lip in humans.

    Electroencephalography and Clinical Neurophysiology   96 巻   頁: 96-104   1996年

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    記述言語:英語  

  187. Reciprocal changes of motor evoked potential preceding voluntary movement.

    Muscle and Nerve   19 巻   頁: 125-131   1996年

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    記述言語:英語  

  188. Effects of tactile interference stimulation on somatosensory evoked magnetic fields.

    Neuro Report   7 巻   頁: 405-408   1996年

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    記述言語:英語  

  189. Effects of judgment process on motor evoked potentials in Go/No-go hand movement task.

    Neuroscience Research   24 巻   頁: 427-430   1996年

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    記述言語:英語  

  190. Pain related responses following CO2 laserstimulation : magnetoencephalographic studies.

    Electroencephalography and Clinical Neurophysiology   47 巻   頁: 111-120   1996年

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    記述言語:英語  

  191. Effects of sleep on somatosensory evoked responses in humans : a magnetoencephalographic study.

    Brain Resaerch, Cognitive Brain Research   4 巻   頁: 275-279   1996年

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    記述言語:英語  

  192. Intracerebral interactions caused by bilateral median nerve stimulation in man : a magnetoencephalographic study.

    Neuroscience Research   24 巻   頁: 175-181   1996年

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    記述言語:英語  

  193. Pain-related somatosensory evoked magnetc fields following lower limb stimulation.

    Electroencephalography and Clinical Neurophysiology   145 巻   頁: 187-194   1996年

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    記述言語:英語  

  194. Topography of somatosensory evoked magnetic fields following posterior tibial nerve stimulation.

    Electroencephalography and Clinical Neurophysiology   95 巻   頁: 127-134   1996年

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    記述言語:英語  

  195. Pain-related somatosensory evoked magnetic fields.

    Electroencephalography and Clinical Neurophysiology   95 巻   頁: 463-474   1995年

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    記述言語:英語  

  196. Gating of somatosernsory evoked responses during active finger movements : magnetoencephalographic studies.

    Journal of Neurological Sciences   128 巻   頁: 195-204   1995年

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    記述言語:英語  

  197. Pain-related magnetic fields following painful CO2 laser stimulation in man.

    Neuroscience Letters   192 巻   頁: 45-48   1995年

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    記述言語:英語  

  198. Somatosensory evoked magnetic fields following mechanical stimulation of the scalp in humans.

    Neuroscience Letters   195 巻   頁: 29-32   1995年

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    記述言語:英語  

  199. Effect of Optokinetic stimulation on the Hneflex in humans

    Japanese Journal of Physiology   44 巻   頁: 67-73   1994年

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    記述言語:英語  

  200. Hypokinesia of associated movement in Parkinson's disease : a symptom in early stapes of the disease

    Journal of Neunology   241 巻   頁: 517-521   1994年

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    記述言語:英語  

  201. 血管破壊性リンパ腫およびneoplastic angioendotheliosis様の浸潤形態をとった悪性リンパ腫の一例 査読有り

    谷田部恭, 中川温子, 橋詰良夫, 竹内有子, 広瀬善清, 宝珠山稔, 森尚義, 浅井淳平

    現代医学     頁: 41(2) : 375-380   1993年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  202. Effect of optokinetic stimulation on human balance recovery in unexpected forward fall.

    Neunoscieuce Research   18 巻   頁: 121-127   1993年

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    記述言語:英語  

  203. Modulation of human balanciup recovery in forward fall by optokinetic stimulation 査読有り

    Environmental Medicine   36 巻   頁: 191-194   1992年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

▼全件表示

書籍等出版物 2

  1. Spatio-temporal source analysis of movement associated magnetic fields.

    Brain Topography, Elsevier, Amsterdam  1998年 

     詳細を見る

    記述言語:英語

  2. Clinical evaluation of Brain Damape by Proton density dynamics

    Advance in Brain Resustation  1991年 

     詳細を見る

    記述言語:英語

MISC 1

  1. 安静時脳磁図ネットワークの加齢性変化の検討

    加藤 隼康, 渡辺 宏久, 大嶽 れい子, 蝦名 潤哉, 吉田 有佑, 小倉 礼, 川畑 和也, 桝田 道人, 原 一洋, 寳珠山 稔, 勝野 雅央, 祖父江 元  

    臨床神経学59 巻 ( Suppl. ) 頁: S318 - S318   2019年11月

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    記述言語:日本語   出版者・発行元:(一社)日本神経学会  

講演・口頭発表等 4

  1. 体性感覚誘発電位(SEP)

    寳珠山 稔

    第40回日本臨床神経生理学会学術大会 

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    開催年月日: 2010年11月

    記述言語:日本語   会議種別:口頭発表(招待・特別)  

    国名:日本国  

    SEP の特性、記録のしかた、反応成分の意味についての教育講演。

  2. Two-point discrimination: evaluation using neurophysiological methods

    29th International Congress of Clinical Neurophysiology 

     詳細を見る

    開催年月日: 2010年10月

    記述言語:英語   会議種別:口頭発表(招待・特別)  

    国名:日本国  

    Cognitive mechanisms for two-point discrimination (TPD) were investigated,
    using new methods of stimulation and evoked potentials.
    (1) Electrical two-point stimulation. Using six ball-shaped electrodes
    placed in line on the dorsal surface of a hand, two points were electrically
    stimulation at a time. The reaction time for TPD was measured for each
    two-point stimulation. The subjects' responses were significantly affected
    by the preceding stimuli as well as the distance of the stimuli: for

  3. Feature binding in the ventral visual pathway revealed bycolor-motion misbinding

    29th International Congress of Clinical Neurophysiology 

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    開催年月日: 2010年10月

    記述言語:英語   会議種別:口頭発表(一般)  

    国名:日本国  

    Objective: Mounting evidence indicates that visual features such as
    shape, color, and motion are processed in specialized regions of the
    brain, while these features are coherently integrated in our conscious
    experiences. How our brain links the features associated with the same
    object is an important problem in neuroscience. Previous studies have
    indicated a critical role of top-down attention in integrating features
    and thus reported an involvement of the dorsal pathway of the visual
    pro

  4. 顔刺激による誘発脳反応の成分とその優位性について

    寳珠山 稔

    日本顔学会「顔学フォーラム2007」 

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    開催年月日: 2007年9月

    記述言語:日本語   会議種別:口頭発表(招待・特別)  

    国名:日本国  

科研費 17

  1. 慢性感覚障害とその評価に関する脳ネットワーク機能異常の検出と慢性疼痛評価法の開発

    研究課題/研究課題番号:20K07881  2020年4月 - 2023年3月

    科学研究費助成事業  基盤研究(C)

    寳珠山 稔, Bagarinao E.

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    担当区分:研究代表者 

    配分額:4290000円 ( 直接経費:3300000円 、 間接経費:990000円 )

    持続的なしびれや疼痛など、他覚的評価が困難な自覚的慢性疼痛の病態を明らかにし適切な治療法を見出すことは、疾患や研究手法を問わず永年の課題となっているものの、未だ解決に至っていない。本研究では、慢性疼痛としての自覚的感覚障害を生じている脳機能状態と機能異常を非侵襲的に検出することを目的とする。本研究ではMEGとEEGでの検出を比較検証することにより、一般臨床での脳活動からの感覚障害評価手法も開発呈示する。本研究成果は、自覚的症状の定量的客観診断手法となるとともに、慢性感覚障害の病態を明らかにすることで治療に関する情報を提供するものと期待される。
    【概要】令和2年度は新型コロナウィルス感染拡大予防措置がとられたものの、疼痛患者からの脳活動記録を蓄積し、これまでのデータ蓄積の解析から論文投稿を行った。現在 Revision 中である。今後は、令和3年度前半に集中して測定データを蓄積する予定である。
    【実施内容】令和2年度には15名の慢性疼痛を有する患者の新規測定を行った。測定は安静時脳活動(脳磁場計測)であり、患者に痛み負担をかけずに脳活動データ収集を行った。
    また、これまでに蓄積された慢性疼痛患者データに新たな解析手法を取り入れ、脳活動(皮質電流密度)と疼痛との関連、疼痛関連脳領域の活動と慢性疼痛との関連が明らかとなったため、論文作成を行った。査読者によるコメントに対する返答を行ったところである(revision 中)。
    新型コロナウィルス感染拡大の中ではあったものの、測定と分析は年度後半に蓄積が進み、概ね順調に推移したと判断できるレベルまで達した。
    今後は、令和3年度前半に集中して測定データを蓄積する予定である。解析は最新の情報科学解析手法を取り入れ、研究目的の完遂を目指す。

  2. 脳機能解析を応用した疼痛評価システムの開発

    研究課題/研究課題番号:19K09647  2019年4月 - 2022年3月

    科学研究費助成事業  基盤研究(C)

    岩月 克之, 下田 真吾, 寳珠山 稔, 栗本 秀, 平田 仁, 大山 慎太郎

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    担当区分:研究分担者 

    神経障害性疼痛中枢性感作の病態を解明し、臨床データ、患者立脚型機能評価等を脳機能解析と組み合わせ、客観的な重症度評価を行う。さらに発展させ、一般病院で使用している機器で測定可能なパラメータを利用することにより、臨床の汎用性が生まれる。本研究の目的は、疼痛の種類・重症度別にパターン化可能な客観的指標の解析を行い、最終的には一般病院に還元可能な疼痛評価法およびそのシステムを構築することである。本研究により信頼性の高い疼痛研究の手法が確立でき、病態解明、臨床評価、治療効果判定までが可能となり、疼痛分野における研究を飛躍的に向上できる。
    複合性局所疼痛症候群(CRPS)の慢性疼痛を脳磁計で解析した。判定指標を使用し、21名のCRPSを有する患者を対象者とした。安静閉眼状態で60秒間の脳磁場記録を行った。脳活動計測は脳磁計を用い、サンプリング周波数5,000 Hz、記録周波数帯域1~1,000 Hzとした。
    1)脳活動計測時に疼痛が強くなかった群(VASが30未満、14計測)と中等度以上の疼痛(VASが30以上、27計測)における電流密度分布の群間比較(t-test, false discovery rate, FDR)
    2)疼痛関連脳領域における平均電流密度と疼痛指標の相関(Pearson’s correlation coefficient, FDR)
    3)2)で有意な相関が得られた脳領域と他の疼痛関連領域とのneural connectivityとVASとの相関(Pearson’s correlation coefficient, FDR)を計算した。Neural connectivityにはorthogonalizationを行ったamplitude envelope correlation(AEC)を用いた。FDRによるq値が0.05以下を有意とした。
    脳活動計測時におけるVASが30未満30以上の2群間の比較では、疼痛指標の低い群で電流密度が有意に高い領域が得られた。領域には、後頭葉から側頭葉下面におよぶ領域、楔前部周辺、右半球島皮質、左帯状回前部などが含まれた。疼痛関連脳領域における平均電流密度と疼痛指標の相関は、大脳皮質領域を疼痛関連領域として大脳半球7領域(左右14領域)を選び、各領域内の平均電流密度と疼痛指標の相関を計算した。皮質14領域のうち疼痛指標と有意な相関が認められたのは右側二次感覚野(SII)のみであった。右二次感覚野とのAECがVASと有意な相関を示したのは右楔前部のみであった。
    COVID-19の影響で年度前半は患者登録ができず、非常に苦労したが、最近は患者登録が少しずつ再開できている。
    COVID-19の情勢に注意しながら、患者登録を引き続き継続していくとともに、今までのデータを解析していく。

  3. 機能連絡解析を駆使したてんかん外科コネクトームマップと定位的脳波記録による実証

    研究課題/研究課題番号:17K10890  2017年4月 - 2020年3月

    前澤 聡

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    担当区分:研究分担者 

    焦点性てんかんに対して安静時fMRIやEEG-fMRI、MEGの新規ネットワーク解析を行い、コネクトームマップを作成しSEEGにて検証した。安静時fMRIの複層的解析では焦点側に強いhubを形成し、対側に向かっての促通性の、またDMNへ抑制性の結合を形成して病態に関連する事が分かった。MEGでは修正DS法を開発しEEG-fMRIではsubsecond解析を開発して、ネットワーク的な焦点診断をより正確にした。Hubより各ネットワークへの結合性の強さを示す新しい指標を開発しコネクトームマップとした。SEEGではまたcoherenceを解析で焦点が形成するネットワークを評価可能である事が分かった。
    学術的意義としては、焦点性てんかんはネットワーク疾患である、という仮説に基づいてネットワーク的な解析を行う事で、てんかんの焦点、及び焦点より形成されるてんかん性ネットワークを明らかにした事が挙げられる。特に安静時fMRI、EEG-fMRI、MEGといったモダリティは非侵襲的であり、改良を加え新規解析を開発した点は、てんかん患者にとって非侵襲的で有効な検査法が増えた事となり、社会的意義が高い。SEEG(定位的頭蓋内電極による脳波記録)は海外で導入が始まっているが日本は遅れをとっており、その安全且つ有効な手法を確立し日本で最初に示し、更に脳波解析の可能性を示した点も意義がある。

  4. 多様なmodalityによる振戦の病態解明とFUSやDBSによる病態修飾

    研究課題/研究課題番号:17K10891  2017年4月 - 2020年3月

    中坪 大輔

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    担当区分:研究分担者 

    本態性振戦などの不随意運動の治療において、非侵襲的な凝固術として、MRガイド下集束超音波治療MRgFUS(MR-guided focused ultrasound)が日本でも可能となった。本研究では、治療後1年後の上肢の改善率が約65%であり、重篤な合併症は認めなかった。また、安静時fMRIによるネットワーク解析により、振戦が重度であるほど、ネットワークの結合性が低下していることが判明し、前頭葉を中心とした高次脳機能の障害も進む傾向にあることが明らかになった。
    本態性振戦の病因、病態に関してはまだ不明な点が多く、小脳―下オリーブ核系の機能異常の関与が示唆されているものの、視床Vim核の治療により、どのように改善するか不明である。安静時fMRIによる本研究では、そのネットワーク異常を可視化し、治療による病態修飾の解明に繋がると考えられる。また、本態性振戦は有効な薬剤がなく、振戦が進行するとMRgFUSなど外科治療でしか症状を緩和することができない。高次脳機能障害を伴うことも多く、どのような患者に治療が有効となるかバイオマーカーを確立することで、振戦で困っている患者の助けとなる。

  5. 脳磁計を用いた安静時および刺激誘発脳活動における脳内神経接続の測定に関する研究

    2015年4月 - 2018年3月

    科学研究費補助金  基盤研究(C)

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    担当区分:研究代表者 

  6. 高齢者、パーキンソン病患者における抑制系回路の加齢および疾患による変化

    研究課題/研究課題番号:15K09350  2015年4月 - 2018年3月

    平山 正昭

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    担当区分:研究分担者 

    脳磁図、MRIを用いて、パーキンソン病(PD )患者の痛みに関する研究を行なった.
    健常人高齢者と PD での体性感覚誘発脳磁場の測定を行い、反回曲線を測定した。健常人高齢者と PD、若年者の1秒間隔での80msの反回抑制を測定した。被検者には安静仰臥位にて右手首正中神経に電極をあて 0.2ms の定電流で 2 回連続刺激を行い電流推定を行った。反回曲線は、若年者と高齢者で1波2波に有意な差が見られた。また、PDと高齢者では1波2波の反応は、1波の抑制が異なっていた。しかし、2波の反応は同様であった。PD患者では加齢に伴う反回抑制の機構の障害が解離していると考えられた。

  7. 脳科学を応用した疼痛関連SNP解析技術の確立

    研究課題/研究課題番号:15K10400  2015年4月 - 2018年3月

    岩月 克之

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    担当区分:研究分担者 

    手根管症候群で母指と中指刺激で体性感覚誘発脳磁場の推定電流源間距離は短いことが認められた。正中神経の2連続刺激により得られるSEFの回復曲線は手根管症候群で早期の回復が認められ、感覚皮質での抑制的神経活動が減少していることが示唆された。coherence解析で島皮質での周波数対応に差が認められ、脳内の接続性異常を検出することが可能になった。同様にCRPS患者においてVASと皮質間coherence値の相関を解析し、帯状回および島皮質、前頭葉などでVAS値とcoherenceが高い負の相関を示し、脳内の接続性異常を検出した。これらの検出結果と生化学的な結果についての相関解析を行った。

  8. 脳磁計を用いた安静時および刺激誘発脳活動における脳内神経接続の測定に関する研究

    研究課題/研究課題番号:15K09349  2015年4月 - 2018年3月

    寳珠山 稔

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    担当区分:研究代表者 

    配分額:4810000円 ( 直接経費:3700000円 、 間接経費:1110000円 )

    安静時および課題遂行時の誘発脳磁活動における神経接続性(connectivity)について脳磁計を用いて明らかにした。研究では、健常人の体性感覚、聴覚、運動の各課題遂行時の脳各皮質領域の接続性を最新の手法を用いて電流分布計算およびconnectivity解析した。病態の解析としては末梢神経障害(手根管症候群)および中枢性疾患(パーキンソン病)を対象に研究を実施した。一連の研究結果は11編の英文専門誌に掲載発表された。本研究によって脳磁場解析手法の確立と大脳皮質接続性の解析から病態の解明に寄与する成果を残すことができた。
    本研究は臨床脳波解析に利用可能な手法であり今後の臨床応用が期待された。

  9. 脳磁計を用いた安静時および刺激誘発脳活動における脳内神経接続の測定に関する研究

    2015年4月 - 2018年3月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    資金種別:競争的資金

  10. 非侵襲的生理学的手法による大脳内神経伝導に関する研究

    2012年4月 - 2015年3月

    科学研究費補助金  基盤研究(C), 課題番号:24591292

    寳珠山 稔

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    担当区分:研究代表者 

  11. 健常人および神経疾患患者における大脳情報処理能力に関する神経生理学的研究

    2002年4月 - 2004年3月

    科学研究費補助金  基盤研究(C), 課題番号:14570588

    珠山 稔

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    担当区分:研究代表者 

  12. 機能回復過程における大脳機能の非侵襲電気生理学的手法による研究

    2000年4月 - 2002年3月

    科学研究費補助金  基盤研究(C), 課題番号:12832024

    寳珠山 稔

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    担当区分:研究代表者 

  13. 随意運動制御機構の大脳生理学的研究

    1998年4月 - 2000年3月

    科学研究費補助金  基盤研究(C), 課題番号:10670614

    寳珠山 稔

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    担当区分:研究代表者 

  14. 大型及び超小型磁場計測装置を用いたヒト高次脳機能の研究

    1998年4月 - 1999年3月

    科学研究費補助金  特定領域研究(A), 課題番号:10164246

    柿木隆介

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    担当区分:研究分担者 

  15. 脳磁図を用いたヒト痛覚認知機構の研究

    1996年4月 - 1999年3月

    科学研究費補助金  萌芽的研究, 課題番号:08878160

    柿木 隆介

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    担当区分:研究分担者 

  16. 生理学的手法(脳磁図,脳波)を用いたヒト脳機能の非侵襲的研究

    1995年4月 - 1997年3月

    科学研究費補助金  基盤研究(B), 課題番号:07458215

    柿木 隆介

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    担当区分:研究分担者 

  17. 生理学的手法(脳磁図,脳波,誘発筋電図)を用いた随意運動発現機構に関する研究

    1995年4月 - 1996年3月

    科学研究費補助金  奨励研究(A), 課題番号:07770485

    寳珠山 稔

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    担当区分:研究代表者 

▼全件表示

 

担当経験のある科目 (本学) 1

  1. 生物学実験

    2011