Updated on 2021/05/14

写真a

 
HOSHIYAMA, Minoru
 
Organization
Graduate School of Medicine Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Title
Professor
Contact information
メールアドレス

Degree 1

  1. 博士(医学)

Research Interests 11

  1. EEG, MEG, SEF, SEP, ERP, EMG, MEG, P300, VEP, AEP

  2. AEP

  3. ERP

  4. VEP

  5. P300

  6. MEG

  7. EMG

  8. SEP

  9. MEG

  10. EEG

  11. SEF

Research Areas 4

  1. Others / Others  / Neurological Medicine

  2. Others / Others  / Clinical Neurophysiology

  3. Others / Others  / Neuroscience

  4. Life Science / Neurology  / Clinical Neurophysiology

Current Research Project and SDGs 1

  1. Neurophysiological studies of mechanisms of sensory and motor systems in human brain

Research History 4

  1. Nagoya University   Graduate School of Medicine   Professor

    2020.4

  2. Nagoya University   Graduate School of Medicine Department of Physical and Occupational Therapy Occupational Therapy   Professor

    2018.4 - 2020.3

  3. Nagoya University   Brain and Mind Research Center Division   Professor

    2013.12 - 2018.3

  4. Nagoya University   Professor

Education 2

  1. Nagoya University   Graduate School, Division of Medicine   Department of Neurology

    - 1994

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 1986

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    Country: Japan

Professional Memberships 12

  1. 日本臨床神経生理学会   評議員

    2009.4

  2. 日本神経学会   評議員

    2009.4

  3. 日本内科学会

  4. 日本生体磁気学会   評議員

    2007.4

  5. 日本生理学会

  6. 日本てんかん学会

  7. 日本てんかん学会

  8. 日本内科学会

  9. 日本臨床神経生理学会

  10. 日本神経学会

  11. 日本生理学会

  12. 日本生体磁気学会

▼display all

 

Papers 185

  1. Relationship between lower limb function and functional connectivity assessed by EEG among motor-related areas after stroke

    Hoshino Takashi, Oguchi Kazuyo, Inoue Kenji, Hoshino Aiko, Hoshiyama Minoru

    TOPICS IN STROKE REHABILITATION     page: 1 - 10   2020.12

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    Publisher:Topics in Stroke Rehabilitation  

    DOI: 10.1080/10749357.2020.1864986

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  2. Identifying the brain's connector hubs at the voxel level using functional connectivity overlap ratio

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Ohdake Reiko, Masuda Michihito, Ogura Aya, Kato Toshiyasu, Koyama Shuji, Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Ozaki Norio, Sobue Gen

    NEUROIMAGE   Vol. 222   page: 117241   2020.11

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  3. Aging Impacts the Overall Connectivity Strength of Regions Critical for Information Transfer Among Brain Networks

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Taoka Toshiaki, Koyama Shuji, Tanabe Hiroki C., Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Ozaki Norio, Sobue Gen

    FRONTIERS IN AGING NEUROSCIENCE   Vol. 12   page: 592469   2020.10

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    Publisher:Frontiers in Aging Neuroscience  

    DOI: 10.3389/fnagi.2020.592469

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  4. Effects of Head Motion on the Evaluation of Age-related Brain Network Changes Using Resting State Functional MRI.

    Kato S, Bagarinao E, Isoda H, Koyama S, Watanabe H, Maesawa S, Mori D, Hara K, Katsuno M, Hoshiyama M, Naganawa S, Ozaki N, Sobue G

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2020.10

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    Publisher:日本磁気共鳴医学会  

    <p>Purpose: The estimation of functional connectivity (FC) measures using resting state functional MRI (fMRI) is often affected by head motion during functional imaging scans. Head motion is more common in the elderly than in young participants and could therefore affect the evaluation of age-related changes in brain networks. Thus, this study aimed to investigate the influence of head motion in FC estimation when evaluating age-related changes in brain networks.</p><p>Methods: This study involved 132 healthy volunteers divided into 3 groups: elderly participants with high motion (OldHM, mean age (±SD) = 69.6 (±5.31), <i>N</i> = 44), elderly participants with low motion (OldLM, mean age (±SD) = 68.7 (±4.59), <i>N</i> = 43), and young adult participants with low motion (YugLM, mean age (±SD) = 27.6 (±5.26), <i>N</i> = 45). Head motion was quantified using the mean of the framewise displacement of resting state fMRI data. After preprocessing all resting state fMRI datasets, several resting state networks (RSNs) were extracted using independent component analysis (ICA). In addition, several network metrics were also calculated using network analysis. These FC measures were then compared among the 3 groups.</p><p>Results: In ICA, the number of voxels with significant differences in RSNs was higher in YugLM vs. OldLM comparison than in YugLM vs. OldHM. In network analysis, all network metrics showed significant (<i>P</i> < 0.05) differences in comparisons involving low vs. high motion groups (OldHM vs. OldLM and OldHM vs. YugLM). However, there was no significant (<i>P</i> > 0.05) difference in the comparison involving the low motion groups (OldLM vs. YugLM).</p><p>Conclusion: Our findings showed that head motion during functional imaging could significantly affect the evaluation of age-related brain network changes using resting state fMRI data.</p>

    DOI: 10.2463/mrms.mp.2020-0081

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  5. Relationship Between Psychological Factors and Wound Occurrence in Patients With Peripheral Arterial Disease in the Leg

    Onoyama Ayaka, Hoshiyama Minoru, Yabe Hiroki

    INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS     page: 1534734620943813   2020.8

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    Publisher:International Journal of Lower Extremity Wounds  

    DOI: 10.1177/1534734620943813

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  6. Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis

    Choy Shao Wei, Bagarinao Epifanio, Watanabe Hirohisa, Ho Eric Tatt Wei, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Taoka Toshiaki, Koyama Shuji, Tanabe Hiroki C., Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Ozaki Norio, Sobue Gen

    HUMAN BRAIN MAPPING   Vol. 41 ( 12 ) page: 3198 - 3211   2020.8

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    Publisher:Human Brain Mapping  

    DOI: 10.1002/hbm.25008

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  7. Action performance in children with autism spectrum disorder at preschool age: a pilot study

    Sano Misako, Yamaguchi Kaori, Fukatsu Reiko, Hoshiyama Minoru

    INTERNATIONAL JOURNAL OF DEVELOPMENTAL DISABILITIES   Vol. 66 ( 4 ) page: 289 - 295   2020.8

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    Publisher:International Journal of Developmental Disabilities  

    DOI: 10.1080/20473869.2019.1580472

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  8. Apathy and depression during the recovery stage after stroke

    Kawasaki Megumi, Hoshiyama Minoru

    INTERNATIONAL JOURNAL OF THERAPY AND REHABILITATION   Vol. 27 ( 5 )   2020.5

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    Publisher:International Journal of Therapy and Rehabilitation  

    DOI: 10.12968/ijtr.2018.0070

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  9. y Distributed source analysis of magnetoencephalography using a volume head model combined with statistical methods improves focus diagnosis in epilepsy surgery

    Ishizaki Tomotaka, Maesawa Satoshi, Nakatsubo Daisuke, Yamamoto Hiroyuki, Takai Sou, Shibata Masashi, Kato Sachiko, Natsume Jun, Hoshiyama Minoru, Wakabayashi Toshihiko

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 5263   2020.3

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  10. Subsecond EEG-fMRI analysis for presurgical evaluation in focal epilepsy. International journal

    Yuji Ito, Satoshi Maesawa, Epifanio Bagarinao, Yu Okai, Daisuke Nakatsubo, Hiroyuki Yamamoto, Hiroyuki Kidokoro, Naotaka Usui, Jun Natsume, Minoru Hoshiyama, Toshihiko Wakabayashi, Gen Sobue, Norio Ozaki

    Journal of neurosurgery   Vol. 134 ( 4 ) page: 1 - 10   2020.3

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    OBJECTIVE: The authors recently reported a novel subsecond analysis method of analyzing EEG-functional MRI (fMRI) to improve the detection rate of epileptic focus. This study aims to validate the utility of this method for presurgical evaluation in pharmacoresistant focal epilepsy. METHODS: Among 13 patients with focal epilepsy undergoing presurgical examinations including simultaneous EEG-fMRI at 3T, 11 patients had interictal epileptiform discharges (IEDs) during fMRI. The authors used the sequence of topographic maps during the IEDs as a reference to obtain subsecond fMRI activation maps with the same temporal resolution as the EEG data, and constructed "spike-and-slow-wave-activation-summary" (SSWAS) maps that showed the activation frequency of voxels during IEDs. Clusters were defined by thresholding the SSWAS maps (voxel value > 10), and those containing voxels with the top 3 highest activation frequencies were considered significant. Significant hemodynamic responses using conventional event-related (ER) analysis and SSWAS maps were compared with the resection areas and surgical outcomes at 1 year after surgery. RESULTS: Using ER analysis, 4 (36%) of 11 patients had significant hemodynamic responses. One of 4 patients had significant hemodynamic responses in the resection area and good surgical outcome. Using SSWAS maps, 10 (91%) of 11 patients had significant hemodynamic responses. Six of 10 patients had significant hemodynamic responses in the resection area, and 5 of the 6 patients achieved good surgical outcomes. The remaining 4 patients had significant hemodynamic responses distant from the resection area, and only 1 of the 4 patients achieved good surgical outcomes. The sensitivity, specificity, positive predictive value, and negative predictive value of SSWAS maps were 83.3%, 75.0%, 83.3%, and 75.0%, respectively. CONCLUSIONS: This study demonstrated the clinical utility of SSWAS maps for presurgical evaluation of pharmacoresistant focal epilepsy. The findings indicated that subsecond EEG-fMRI analysis may help surgeons choose the resection areas that could lead to good surgical outcomes.

    DOI: 10.3171/2020.1.JNS192567

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  11. Electroencephalographic Functional Connectivity With the Tacit Learning System Prosthetic Hand: A Case Series Using Motor Imagery

    Iwatsuki Katsuyuki, Hoshiyama Minoru, Oyama Shintaro, Yoneda Hidemasa, Shimoda Shingo, Hirata Hitoshi

    FRONTIERS IN SYNAPTIC NEUROSCIENCE   Vol. 12   page: 7   2020.2

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    Publisher:Frontiers in Synaptic Neuroscience  

    DOI: 10.3389/fnsyn.2020.00007

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  12. Electroencephalographic Functional Connectivity with the Tacit Learning System Prosthetic Hand: a case series using motor imagery Reviewed

    Katsuyuki Iwatsuki, Minoru Hoshiyama, SHintaro Oyama, Hidemasa Yoneda, Shingo Shimoda, Katsuyuki Iwatsuki , Minoru Hoshiyama, Shintaro Oyama, Hidemasa Yoneda, Shingo Shimoda and Hitoshi Hirata,

    Front. Synaptic Neurosci.     2020.2

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  13. Relationship between upper limb function and functional neural connectivity among motor related-areas during recovery stage after stroke

    Hoshino Takashi, Oguchi Kazuyo, Inoue Kenji, Hoshino Aiko, Hoshiyama Minoru

    TOPICS IN STROKE REHABILITATION   Vol. 27 ( 1 ) page: 57 - 66   2020.1

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    Publisher:Topics in Stroke Rehabilitation  

    DOI: 10.1080/10749357.2019.1658429

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  14. Disturbance of somatotopic spatial cognition and extra-territorial pain in carpal tunnel syndrome

    Yoshida Akihito, Iwatsuki Katsuyuki, Hoshiyama Minoru, Hirata Hitoshi

    NEUROREHABILITATION   Vol. 46 ( 3 ) page: 423 - 431   2020

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    Publisher:NeuroRehabilitation  

    DOI: 10.3233/NRE-193007

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  15. Effect of environmental music on autonomic function in infants in intensive and growing care units

    Hasegawa Y.

    Journal of Neonatal-Perinatal Medicine   Vol. 13 ( 3 ) page: 395 - 401   2020

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    Publisher:Journal of Neonatal-Perinatal Medicine  

    DOI: 10.3233/NPM-180174

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  16. 運動関連領域脳波のfunctional connectivityによる脳卒中後の上肢機能の予後予測:麻痺の重症度を考慮した検討

    星野 高志, 小口 和代, 井上 健二, 寳珠山 稔

    理学療法学Supplement   Vol. 47 ( 0 ) page: F - 83_2-F-83_2   2020

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    Publisher:公益社団法人 日本理学療法士協会  

    DOI: 10.14900/cjpt.47S1.F-83_2

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  17. A magnetoencephalographic study of longitudinal brain function alterations following carpal tunnel release

    Iwatsuki Katsuyuki, Hoshiyama Minoru, Yoshida Akihito, Shinohara Takaaki, Hirata Hitoshi

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 19776   2019.12

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  18. Meaningful occupation: A self-awareness intervention for patients with unilateral spatial neglect Reviewed

    Kaori KAWABATA and Minoru HOSHIYAMA

    New Zealand Journal of Occupational Thearpy     page: in press   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  19. Action performance in children with autism spectrum disorder at preschool age: A pilot study Reviewed

    Misako Sano, Kaori Yamaguchi, Reiko Fukatsu, Minoru Hoshiyama

    International Journal of Developmental Dissabilities     page: in press   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  20. Action performance in children with autism spectrum disorder at preschool age: A pilot study Reviewed

    Misako Sano, Kaori Yamaguchi, Reiko Fukatsu, Minoru Hoshiyama

    International Journal of Developmental Dissabilities     page: in press   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  21. Meaningful occupation: A self-awareness intervention for patients with unilateral spatial neglect Reviewed

    Kaori KAWABATA, Minoru HOSHIYAMA

    New Zealand Journal of Occupational Thearpy     page: in press   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  22. Reorganization of brain networks and its association with general cognitive performance over the adult lifespan. Reviewed International journal

    Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshiaki Taoka, Shuji Koyama, Hiroki C Tanabe, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Norio Ozaki, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Gen Sobue

    Scientific reports   Vol. 9 ( 1 ) page: 11352 - 11352   2019.8

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    Healthy aging is associated with structural and functional changes in the brain even in individuals who are free of neurodegenerative diseases. Using resting state functional magnetic resonance imaging data from a carefully selected cohort of participants, we examined cross sectional changes in the functional organization of several large-scale brain networks over the adult lifespan and its potential association with general cognitive performance. Converging results from multiple analyses at the voxel, node, and network levels showed widespread reorganization of functional brain networks with increasing age. Specifically, the primary processing (visual and sensorimotor) and visuospatial (dorsal attention) networks showed diminished network integrity, while the so-called core neurocognitive (executive control, salience, and default mode) and basal ganglia networks exhibited relatively preserved between-network connections. The visuospatial and precuneus networks also showed significantly more widespread increased connectivity with other networks. Graph analysis suggested that this reorganization progressed towards a more integrated network topology. General cognitive performance, assessed by Addenbrooke's Cognitive Examination-Revised total score, was positively correlated with between-network connectivity among the core neurocognitive and basal ganglia networks and the integrity of the primary processing and visuospatial networks. Mediation analyses further indicated that the observed association between aging and relative decline in cognitive performance could be mediated by changes in relevant functional connectivity measures. Overall, these findings provided further evidence supporting widespread age-related brain network reorganization and its potential association with general cognitive performance during healthy aging.

    DOI: 10.1038/s41598-019-47922-x

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  23. Magnetoencephalographic evaluation for the myoelectric hand prosthesis with tacit learning system.

    Iwatsuki K, Hoshiyama M, Oyama S, Shimoda S, Hirata H

    NeuroRehabilitation   Vol. 44 ( 1 ) page: 19 - 23   2019

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    DOI: 10.3233/NRE-182514

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  24. Anatomo-electro-clinical correlations of hypermotor seizures with amygdala enlargement: Hippocampal seizure origin identified using stereoelectroencephalography.

    Ishizaki T, Maesawa S, Nakatsubo D, Yamamoto H, Shibata M, Kato S, Yoshida M, Natsume J, Hoshiyama M, Wakabayashi T

    Epilepsy & behavior case reports   Vol. 11   page: 10 - 13   2019

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    DOI: 10.1016/j.ebcr.2018.09.011

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  25. 脳卒中後の運動機能とfunctional connectivityの変化:-脳波の運動関連領域6電極による一症例での検討-

    星野 高志, 小口 和代, 寳珠山 稔

    理学療法学Supplement   Vol. 46 ( 0 ) page: E - 63_1-E-63_1   2019

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    Publisher:公益社団法人 日本理学療法士協会  

    <p>【はじめに・目的】 </p><p>脳活動のネットワークとしての機能が明らかにされつつある中で、皮質各領域間のfunctional connectivity (FC) が重要視されている。脳卒中後は主に半球内,半球間のFCの低下が報告されており,運動機能のバイオマーカーとして注目されている。FC は研究領域では測定されているものの,機器や費用面からリハビリテーション領域への応用には課題が多い。脳波 (EEG) は比較的安価でベッドサイド等でも簡便に測定可能である。本研究では脳卒中1症例を対象にEEGを用い,運動関連領域6電極に限定してFCを解析し,運動機能との関連を調べた。</p><p>【方法】 </p><p>対象は脳梗塞 (左内包後脚~放線冠) で右片麻痺を呈した40歳代男性1名とした。運動機能はSIAS運動項目 (SIAS-m) ,Fugl-Meyer 評価法 上肢項目 (FMAU) ・下肢項目 (FMAL) ,簡易上肢機能検査 (STEF) を用いて評価した。EEGは日本電気三栄社製 Biotop (6R-12) を用い,国際10-10法に準じてC3, C4, FC3, FC4, Cz, FCzの6電極で測定した (sampling周波数1000Hz) 。課題条件は麻痺側手指運動 (手指条件) および足関節底背屈運動 (足条件) 各30秒間とした。解析はBrainstormを用い,notch filter,band pass filter 0.5-100Hzで前処理後,β帯域 (12-30Hz) における各電極間のFCをamplitude envelope correlation (AEC) にて分析した。評価・測定は発症後1ヶ月,2ヶ月および9ヶ月に実施した。</p><p>【結果】 </p><p>運動機能に関してSIAS-mは発症後1 / 2 / 9ヶ月の順に 3-1,4-4-1 / 3-1,4-4-1 / 4-4,4-4-1だった。上肢はFMAU 45 / 53 / 66,STEF 36 / 51 / 81と経時的に改善,下肢はFMAL 20 / 25 / 27であった。AECは,手指条件では機能改善に伴い半球間 (C3-C4,FC3-FC4) および非損傷半球内 (C4-FC4) で減少,損傷半球内 (C3-FC3) は変化なかった。一方,足条件では半球間および損傷半球内は機能変化に伴い若干増加し,非損傷半球内は変化なかった。また運動前領域正中~損傷半球 (FCz-C3,FCz-FC3) および非損傷半球 (FCz-C4,FCz-FC4) では2条件とも経時的に増加した。</p><p>【考察】 </p><p>上肢機能は手指で顕著に改善した。機能回復レベルには非損傷半球からの半球間抑制が関与する (Silasi et al., 2014) ため,手指条件での半球間および非損傷半球内のAECの減少は半球間抑制の減弱を反映していると推察した。一方,足条件のAECは手指と異なり半球間抑制の減弱に値する変化を示さなかった。これは手指と足での半球間抑制の違い (Volz et al., 2015) や,足関節の麻痺の残存などが原因と考えた。また手指条件での損傷半球内AECが初期から高値で変化がないことから,手指の機能予後を反映する可能性も考えられた。運動前領域正中~損傷半球および非損傷半球間のAECは2条件とも経時的に大きく増加した。この変化は脳卒中後の運動発現に関する神経機序の回復や再構築を示していると推察した。Wu et al. (2015) は機能回復の程度は損傷側の運動野と運動前野のFCに相関すると報告しており,本研究でも類似の変化が認められた。今後多数症例でこれらの仮説の検証を行いたい。</p><p>【倫理的配慮,説明と同意】</p><p>本研究はヘルシンキ宣言を遵守し,名古屋大学医学部医学系研究科生命倫理審査委員会(承認番号17-602),および刈谷豊田総合病院倫理委員会(第302号)の承認を得て実施した。対象者には書面にて本人に研究の趣旨を説明し,同意を得た。</p>

    DOI: 10.14900/cjpt.46S1.E-63_1

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  26. Evaluation of the Brain Function for the Myoelectric Hand Prosthesis with Tacit Learning System

    Iwatsuki Katsuyuki, Oyama Shintaro, Hoshiyama Minoru, Shimoda Shingo, Hirata Hitoshi

    CONVERGING CLINICAL AND ENGINEERING RESEARCH ON NEUROREHABILITATION III   Vol. 21   page: 248 - 251   2019

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    Publisher:Biosystems and Biorobotics  

    DOI: 10.1007/978-3-030-01845-0_49

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  27. Assessment of attention function recovery in patients after stroke using sequential desk-top tasks

    Tanikaga Miki, Muzuno Jumpei, Tanaka Masahiro, Hoshiyama Minoru

    INTERNATIONAL JOURNAL OF THERAPY AND REHABILITATION   Vol. 25 ( 12 ) page: 665 - 674   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.12968/ijtr.2018.25.12.665

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  28. Brain Activity on Observation of Another Person's Action: A Magnetoencephalographic Study.

    Mizuno J, Kawamura M, Hoshiyama M

    Motor control   Vol. 22 ( 4 ) page: 377 - 390   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1123/mc.2017-0053

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  29. Use of parametric speaker for older people with dementia in a residential care setting: A preliminary study of two cases.

    Nishiura Y, Hoshiyama M, Konagaya Y

    Hong Kong journal of occupational therapy : HKJOT   Vol. 31 ( 1 ) page: 30 - 35   2018.6

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    DOI: 10.1177/1569186118759611

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  30. An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan. International journal

    Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshihiko Wakabayashi, Masafumi Kuzuya, Norio Ozaki, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Gen Sobue

    NeuroImage   Vol. 169   page: 134 - 144   2018.4

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    This study aims to elucidate age-related intrinsic brain volume changes over the adult lifespan using an unbiased data-driven structural brain parcellation. Anatomical brain images from a cohort of 293 healthy volunteers ranging in age from 21 to 86 years were analyzed using independent component analysis (ICA). ICA-based parcellation identified 192 component images, of which 174 (90.6%) showed a significant negative correlation with age and with some components being more vulnerable to aging effects than others. Seven components demonstrated a convex slope with aging; 3 components had an inverted U-shaped trajectory, and 4 had a U-shaped trajectory. Linear combination of 86 components provided reliable prediction of chronological age with a mean absolute prediction error of approximately 7.2 years. Structural co-variation analysis showed strong interhemispheric, short-distance positive correlations and long-distance, inter-lobar negative correlations. Estimated network measures either exhibited a U- or an inverted U-shaped relationship with age, with the vertex occurring at approximately 45-50 years. Overall, these findings could contribute to our knowledge about healthy brain aging and could help provide a framework to distinguish the normal aging processes from that associated with age-related neurodegenerative diseases.

    DOI: 10.1016/j.neuroimage.2017.12.014

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  31. Detecting sub-second changes in brain activation patterns during interictal epileptic spike using simultaneous EEG-fMRI. International journal

    Epifanio Bagarinao, Satoshi Maesawa, Yuji Ito, Naotaka Usui, Jun Natsume, Hirohisa Watanabe, Minoru Hoshiyama, Toshihiko Wakabayashi, Gen Sobue, Shinji Naganawa, Haruo Isoda

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology   Vol. 129 ( 2 ) page: 377 - 389   2018.2

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    OBJECTIVE: Epileptic spikes are associated with rapidly changing brain activation involving the epileptic foci and other brain regions in the "epileptic network". We aim to resolve these activation changes using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) recordings. METHODS: Simultaneous EEG-fMRI recordings from 9 patients with epilepsy were used in the analysis. Our method employed the whole scalp EEG data to generate regressors for the analysis of fMRI data using the general linear model. RESULTS: We were able to resolve, with milliseconds temporal resolution, changes in activation patterns involving suspected epileptic foci and other brain regions in the epileptic network during spike and slow wave. Using summary maps (called SSWAS maps) which show the activation frequency of voxels, we found that suspected epileptic foci tend to be significantly active during this interval. SSWAS maps also enabled the detection of the epileptic foci in 4 of 5 patients where the conventional event-timing-based analysis failed to identify. CONCLUSION: These findings demonstrated the efficacy of the method and the potential application of SSWAS maps to identify epileptic foci. SIGNIFICANCE: The method could help resolve activation changes during epileptic spike and could provide insights into the underlying pathophysiology of these changes.

    DOI: 10.1016/j.clinph.2017.11.018

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  32. Feed-forward-related neural activity for vocalization: A pilot study using magnetoencephalography

    Kawamura M.

    Neurology Psychiatry and Brain Research   Vol. 27   page: 21 - 26   2018.2

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    DOI: 10.1016/j.npbr.2017.12.006

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  33. Study on Estimation of MMSE Score by Using the Latency of P300 and Alpha Wave

    Miwa Koki, Yoshikawa Tomohiro, Furuhashi Takeshi, Hoshiyama Minoru, Makino Taeko, Yanagawa Madoka, Suzuki Yusuke, Umegaki Hiroyuki, Kuzuya Masafumi

    2018 JOINT 10TH INTERNATIONAL CONFERENCE ON SOFT COMPUTING AND INTELLIGENT SYSTEMS (SCIS) AND 19TH INTERNATIONAL SYMPOSIUM ON ADVANCED INTELLIGENT SYSTEMS (ISIS)     page: 195 - 199   2018

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    Publisher:Proceedings - 2018 Joint 10th International Conference on Soft Computing and Intelligent Systems and 19th International Symposium on Advanced Intelligent Systems, SCIS-ISIS 2018  

    DOI: 10.1109/SCIS-ISIS.2018.00041

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  34. Identification of Partial Regression Coefficient of Alpha Wave for Estimation of MMSE Score

    MIWA Koki, Yoshikawa Tomohiro, Furuhashi Takeshi, Hoshiyama Minoru, Makino Taeko, Yanagawa Madoka, Suzuki Yusuke, Umegaki Hiroyuki, Kuzuya Masafumi

    Proceedings of the Fuzzy System Symposium   Vol. 34 ( 0 ) page: 15 - 18   2018

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    <p>The number of elderly people with dementia increases year by year, and about 20% of people in Japan over 65 years old are estimated to be dementia patients in 2030. Because dementia is difficult to be treated after the symptoms advance, early detection of dementia is important. The peak latency of P300 is one of the EEG (Electroencephalogram) features. It has been reported that the peak latency of P300 is dependent on MMSE (Mini-Mental State Examination) score. If MMSE score can be estimated by measuring the latency of P300, it is expected to be used for the early detection of dementia. However, no regression equation between MMSE score and the latency of P300 had been identified yet. The authors measured the peak latency of P300 of dementia patients who were attending the Geriatrics of Nagoya University hospital and identified a multiple regression equation with MMSE score as the objective variable, and the latency of P300, age, educational background as the explanatory variables. The 95% confidence interval of estimated MMSE score was ±3.15. This paper incorporates alpha wave as a new explanatory variable for the regression equation. The result shows that the alpha wave is statistically significant for the estimation of the MMSE score, and the 95% confidence interval of estimated MMSE score is reduced to ±3.09.</p>

    DOI: 10.14864/fss.34.0_15

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  35. Association between changes in visual evoked magnetic fields and non-motor features in Parkinson's disease

    Yoshiro Fujisawa, Tomomi Minato, Jun-ichi Uemura, Minoru Hoshiyama, Hirohisa Watanabe, Masaaki Hirayama

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 2 ) page: 147 - 155   2017.5

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    Visual dysfunction can be caused by several abnormalities, including dysfunctions in the visual cortex and retina. Our aim was to investigate changes in visual evoked brain responses in the primary visual cortex associated with Parkinson's disease (PD). Sixteen healthy control subjects and ten patients with PD participated in this study. We assessed the visual evoked magnetic field (VEF) using magnetoencephalography (MEG). Checkerboard pattern reversal (CPR) and monotonous grating pattern (MGP) stimulations were used. Magnetic resonance imaging (MRI) was performed to analyze brain volume and generate a tractogram. Cognitive and olfactory function, and Unified Parkinson's Disease Rating Scale (UPDRS) scores were evaluated in patients with PD. Four components of the VEF (1M, 2M, 3M, 4M) were observed following stimulation. For both stimuli, results from the 1M and 2M components were significantly greater and the latency of the 1M component was increased markedly in the PD group compared with the healthy control group. In the PD group, 1M latency correlated with the UPDRS score of 1 for both stimuli, and a correlation was observed between olfactory function and the UPDRS score of 3 for the CPR stimulation alone. We suggest that the conduction delay observed following visual stimulation occurs peripherally rather than in the primary visual cortex. Degeneration of selective elements of the visual system in the retina, possibly midget cells, may be involved.

    DOI: 10.18999/nagjms.79.2.147

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  36. Functional inter-cortical connectivity among motor-related cortices during motor imagery: A magnetoencephalographic study

    Yota Obayashi, Jun-ichi Uemura, Minoru Hoshiyama

    SOMATOSENSORY AND MOTOR RESEARCH   Vol. 34 ( 1 ) page: 1 - 8   2017.3

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    Neural connectivity was measured during motor imagery (MI) and motor execution (ME) using magnetoencephalography in nine healthy subjects, MI, and at rest. Lower coherence values during ME and MI between sensorimotor areas than at rest, and lower values during MI between the left supplementary motor area and inferior frontal gyrus than ME suggested the sensorimotor network of MI functioned with similar connectivity to ME and that the inhibitory activity functioned continuously during MI, respectively.

    DOI: 10.1080/08990220.2016.1257985

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  37. The temporal stability and variability across frequency bands in neural synchrony between primary and secondary somatosensory areas following somatosensory stimulation

    Jun-ichi Uemura, Minoru Hoshiyama

    Clinical Neurophysiology Practice   Vol. 2   page: 119 - 123   2017

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    Objectives: To examine the temporal stability and variability of neuronal synchronization among the contralateral primary somatosensory cortex (cSI) and contralateral (cSII) and ipsilateral secondary somatosensory cortex (iSII) in response to median nerve stimulation. Methods: Both the spontaneous magnetoencephalography (MEG) signals as the pre-stimulus condition and somatosensory evoked magnetic-fields (SEF) were recorded in eleven healthy subjects. We calculated a phase-locking value (PLV) between two areas among cSI, cSII, and iSII in five frequency bands (theta: 5–7 Hz, alpha: 8–12 Hz, beta: 15–29 Hz, gamma-1: 30–59 Hz, and gamma-2: 60–90 Hz), and compared the PLV among in pre-stimulus and stimulus conditions. Results: The PLV between cSI and cSII for the theta band activity varied within 2 s from the stimulus onset. On the other hand, the PLV between cSI and iSII for the alpha band did not vary within 2 s. Conclusion: The fluctuation of neuronal synchrony among sensory-related cortices in response to median nerve stimulation depends on the induced frequency band and inter-region. Significance: This study is the first to report the temporal characteristic of stimulus-driven neural synchrony following somatosensory stimulation.

    DOI: 10.1016/j.cnp.2017.05.002

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  38. Physical Therapy for Motor and Sensory Symptoms Due to Mononeuritis Multiplex and Steroid Myopathy in a Patient with Eosinophilic Granulomatosis with Polyangiitis

    HOSHINO Takashi, OGUCHI Kazuyo, HOSHIYAMA Minoru

    Physical Therapy Japan   Vol. 44 ( 3 ) page: 226 - 231   2017

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    DOI: 10.15063/rigaku.11240

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  39. 急性期脳卒中者の自律神経機能の回復過程:糖尿病の影響

    星野 高志, 小口 和代, 寳珠山 稔

    理学療法学Supplement   Vol. 2016 ( 0 )   2017

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    <p>【はじめに】</p><p></p><p>急性期脳卒中では自律神経機能(autonomic nervous function,ANF)の低下が報告されているが詳細は明らかではない(Orlandi, 2000)。脳卒中早期のリハビリテーション(リハ)において,姿勢変化による血圧変動は脳血流に直接影響するため十分考慮すべき点であり,ANFの測定には非侵襲性,簡便性から心拍変動(heart rate variability,HRV)がよく用いられる(Raedt, 2015)。また,脳卒中の主な併存症である糖尿病(DM)患者においてもANFは低下する(Stuckey, 2013)。本研究ではHRVを用いて急性期脳卒中におけるANFの回復過程をDMの併存に着目して検討した。</p><p></p><p></p><p>【方法】</p><p></p><p>対象は急性期初発脳卒中者のうち,自律神経作動薬の使用者や,著明な不整脈,DM性末梢神経障害を有するものを除外した30名とし,DMのないS群DMを有するDM群に分けた。第7病日までを評価期間とし,各回背臥位(pre),端座位(sit),背臥位(post)の順に姿勢変換した。HRVは各姿勢5分間の心拍データを周波数解析し,高周波成分(HF:0.15~0.4Hz)のnormalized unit(HFnu)を副交感神経,低周波成分(LF:0.04~0.15Hz)とHFの比(LF/HF比)を交感神経の指標とした。心拍数(HR),血圧(SBP,DBP)は3回の平均を用いた。各指標の姿勢変換による影響と経時的変化を検討した。統計処理はTukey-Kramer法,Spearmanの順位相関係数を用い,有意水準は5%未満とした。</p><p></p><p></p><p>【結果】</p><p></p><p>S群は23名(平均60±11歳,NIHSS 8点(中央値)),DM群は7名(59±13歳,NIHSS 5点,HbA1c 6.7%(中央値))であった。S群では第3病日以降,HFnuはsitで低下しpostで上昇,LF/HF比,DBP,HRはsitで上昇しpostで低下する一定の変化を示した。経時的にはLF/HF比,HFnu,SBPおよびHRで第2,第3病日に比べ第7病日で有意差が見られ,HFnuは経過日数と正の相関,LF/HF比,SBP,HRは負の相関を示した。一方,DM群では姿勢変換に対し,第4病日以降,HRのみsitで上昇を示したが,他の指標は第7病日においても一定しなかった。SBPのみ経過日数と負の相関を示した。</p><p></p><p></p><p>【結論】</p><p></p><p>DMのない急性期脳卒中者のANFは,第3病日には交感神経,副交感神経とも姿勢変換に適応して変化し,経時的に副交感神経は第7病日まで日ごとに上昇,交感神経は低下していた。これは,発症直後は交感神経活動が亢進しておりSBP,HRが高値となるが,1週までに副交感神経活動が徐々に上昇することを示唆していた。またDM併存症例では一定の傾向を示さず,1週後でもANFは安定していないと考えられた。これらは脳卒中早期リハ実施におけるリスク管理上,考慮すべき点と考えられた。</p>

    DOI: 10.14900/cjpt.2016.1023

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  40. Neuroscientific evidence for multisensory convergence and interaction Invited Reviewed

    Tanaka E, Kida T, Kakigi R, Hoshiyama M

    J Phys Fitness Sports Med   Vol. 6 ( 5 ) page: 301 - 310   2017

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    DOI: 10.7600/jpfsm.6.301

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  41. Visual function assessment in stroke patients using a dynamic three-dimensional visual tasks

    Suzuki Megumi, Hoshiyama Minoru, Yamada Masayuki, Maeda Akiko, Saitoh Eiichi

    Fujita Medical Journal   Vol. 3 ( 3 ) page: 67 - 71   2017

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    <p><b>Objectives:</b> Patients with right-hemisphere brain lesions often show unilateral neglect, which causes various difficulties in their daily lives. Disturbances in visuospatial cognition, including unilateral neglect, can be tested quantitatively using questionnaires, yet visuospatial cognition is related not only to the visual system, but also to other cognitive and behavioral functions. Such functions should be assessed by integrative visuo-cognitive tasks. Therefore, the objective of the present study was to clarify visual disturbances in patients with brain lesions using multi-modal visual function tests including three-dimensional and dynamic visual tasks.</p><p><b>Methods:</b> We recruited 29 patients, 14 with right- and 15 with left-hemispheric brain lesions, and age-matched control subjects. We conducted depth perception tests and static and active motion detection tests to clarify subjects' three-dimensional visual recognition performance.</p><p><b>Results:</b> There were no significant differences between the patients and controls on any of the visual function tests, except for the static detection test with a mosaic background. However, patients' total scores on the visual function tests were lower than those of the controls.</p><p><b>Discussion:</b> The observed decline in total visual function scores suggests that visual dysfunction caused by stroke should be evaluated not by a single visual function test, but by a series of such tests. We propose that visual functioning in daily life should be evaluated using multi-modal visual function tests.</p>

    DOI: 10.20407/fmj.3.3_67

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  42. Biomechanical Reconstruction Using the Tacit Learning System: Intuitive Control of Prosthetic Hand Rotation Reviewed

    Shintaro Oyama,Shingo Shimoda,Fady SK Alnajjar,Katsuyuki Iwatsuki,Minoru Hoshiyama,Hirotaka Tanaka,Hitoshi Hirata

    Frontiers in Neurorobotics   Vol. 00 ( 00 ) page: in press   2016.12

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  43. Distinctive distribution of brain volume reductions in MELAS and mitochondrial DNA A3243G mutation carriers: A voxel-based morphometric study. Reviewed

    Tsujikawa K, Senda J, Yasui K, Hasegawa Y, Hoshiyama M, Katsuno M, Sobue G.

    Mitochondrion   Vol. 30   page: 229-235   2016.8

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  44. Recovery function of somatosensory evoked brain response in patients with carpal tunnel syndrome: A magnetoencephalographic study. Reviewed

    Iwatsuki K, Yoshida A, Shinohara T, Nakano T, Uemura J, Goto S, Hirayama M, Hoshiyama M, Hirata H.

    Clin Neurophysiol   Vol. 127 ( 8 ) page: 2733-2738   2016.5

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  45. Disinhibitory shift of recovery curve of somatosensory-evoked response in elderly: A magnetoencephalographic study. Reviewed

    Goto S, Fujisawa Y, Uemura J, Yamada S, HOSHIYAMA M, Hirayama M.

    Clinical Neurophysiology   Vol. 126 ( 6 ) page: 1228-1233   2015.6

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    DOI: 10.1016/j.clinph.2014.09.018

  46. Effect of Cognitive Load on Seating Posture in Children. Reviewed

    Igarashi Go, Karashima Chieko, HOSHIYAMA Minoru

    Occupational Thererapy International     2015

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    DOI: 10.1002/oti.1405

  47. Compensatory postural sway while seated posture during tasks in children with autism spectrum disorder. Reviewed

    FUNAHASHI Yoshimi, KARASHIMA Chieko, HOSHIYAMA Minoru

    Occupational Thererapy International   Vol. 21 ( 4 ) page: 166-175   2014.12

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    DOI: 10.1002/oti.1375

  48. Effectiveness of midazolam for L-arginine-resistant headaches during stroke-like episodes in MELAS: a case report. Reviewed

    Tsujikawa K, Yokoi S, Yasui K, Hasegawa Y, HOSHIYAMA M, Yanagi T.

    Rinsho Shinkeigaku   Vol. 2014 ( 54 ) page: 882-887   2014.11

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  49. Behavioral and physiological observation during the daytime: How patients with advanced dementia spend the time in a care facility. Reviewed

    YAMAGUCHI Kaori, HOSHIYAMA Minoru

    Asian J Occup Ther     page: in press   2013.8

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  50. Effects of emotional music on visual processes in inferior temporal area. Reviewed

    JOMORI Izumi, HOSHIYAMA Minoru, UEMURA Jun-ichi, NAKAGAWA Yoshiro, HOSHINO Aiko, IWAMOTO Yuko.

    Cognitive Neuroscience   Vol. 4 ( 1 ) page: 21-30   2013.4

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  51. Time orientation during the day in the elderly with dementia. Reviewed

    IWAMOTO Yuko, HOSHIYAMA Minoru.

    Physical and Occupational Therapy in Geriatrics     page: in press   2012.10

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  52. Auditory mismatch response modified by visual stimulation accompanied with auditory stimulation. Reviewed

    NAKAGAWA Yoshiro, HOSHIYAMA Minoru, UEMURA Jun-ichi, JOMORI Izumi

    Neurophysiology   Vol. 44 ( 3 ) page: in press   2012.5

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  53. Virbroarthrography in patients with knee arthropathy. Reviewed

    TANAKA Noriyuki, HOSHIYAMA Minoru

    J Back Musculoskelet Rehab   Vol. in press   page: 000-001   2012.4

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  54. Articular sound and clinical stages in knee arthropathy. Reviewed

    TANAKA Noriyuki, HOSHIYAMA Minoru

    J Musculoskelet Res   Vol. 14 ( 1 ) page: 1-9   2012.4

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    DOI: DOI: 10.1142/S021895771500060

  55. Kinematic analysis of sit to stand by persons with rheumatoid arthritis supported by a service dog. Reviewed

    NOGUCHI Hiromi, TAGAWA Yoshikatsu, HOSHIYAMA Minoru

    Disab Rehab Assist Tech   Vol. 7 ( 1 ) page: 45-54   2012.2

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  56. Alteration of time perception in young and elderly people during jigsaw puzzle tasks with different complexities. Reviewed

    IWAMOTO Yuko, HOSHIYAMA Minoru, TAGAWA Yoshikatsu

    Occup Ther Int   Vol. 18   page: 194-200   2011.7

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  57. Difference in P300 response between hemi-field visual stimulation Reviewed

    SUZUKI Megumi, HOSHIYIAMA Minoru

    Neurol Sci   Vol. 32   page: 603-308   2011.5

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  58. Biological observation during the daytime of elderly patients with advanced dementia cared for with and without artificial nutrition by percutaneous endoscopic gastrostomy (PEG). Reviewed

    YAMAGUCHI Kaori, HOSHIYAMA Minoru, TAKANO Masanori

    Geriat Geron Int   Vol. 11 ( 2 ) page: 221-228   2011.4

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  59. An integration of color and motion information in visual scene analyses.

    NOGUCHI Yasuyuki, KAKIGI Ryusuke, HOSHIYAMA Minoru

    Psychol Sci   Vol. 22 ( 2 ) page: 153-158   2011.2

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  60. Frontal activity during imagination of rhythm: An event-related potential study. Reviewed

    JOMORI Izumi, UEMURA Jun-Ichi, NAKAGAWA Yoshiro, HOSHIYAMA Minoru

    J Clin Neurosci     page: in press   2011

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  61. Kinematic analysis of seating maneuver: Digitalization of movement in daily living. Reviewed

    TAKEI Maki, SHIMIZU Hideki, HOSHIYAMA Minoru.

    Hum Mov   Vol. 11 ( 2 ) page: 114-118   2010.12

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  62. Effect of task-irrelevant high-speed verbal stimulation on a visual/verbal word-discrimination task: An event-related potential study. Reviewed

    UEMURA Jun-Ichi, HOSHIYAMA Minoru.

    Clin Neurophysiol   Vol. 121 ( 12 ) page: 2065-2069   2010.12

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  63. Does self-efficacy to falls in hip-protector users affect quality of life (QOL) and physical activity in nursing homes in Japan? Reviewed

    KATO Chikako, IDA Kunio, HOSHIYAMA Minoru, HARADA Atsushi

    J Am Geriat Soc   Vol. 58 ( 9 ) page: 1810-1812   2010.9

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  64. *Effects of music therapy on involuntary swallowing. Reviewed

    Jomori I, Hoshiyama M.

    Nord J Music Ther.   Vol. 19 ( 1 ) page: 51-62   2010.1

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  65. *Auditory brain response modified by temporal deviation of language rhythm: an auditory event-related potential study. Reviewed

    Jomori I, Hoshiyama M.

    Neurosci Res   Vol. 65 ( 2 ) page: 187-193   2009.10

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  66. The characteristics of no-go potentials with intraepidermal stimulation. Reviewed

    Nakata H, Sakamoto K, Inui K, Hoshiyama M, Kakigi R.

    Neuroreport   Vol. 20 ( 13 ) page: 1149-1154   2009.8

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  67. *Attention deficits of patients with chronic-stage traumatic brain injury: a behavioral study involving a dual visuo-spatial task. Reviewed

    Hasegawa J, Hoshiyama M.

    J Clin Exp Neuropsychol   Vol. 31 ( 3 ) page: 1227-1237   2009.4

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  68. Centrifugal modulation of human LEP components to a task-relevant noxious stimulation triggering voluntary movement. Reviewed

    Nakata H, Sakamoto K, Honda Y, Mochizuki H, Hoshiyama M, Kakigi R.

    Neuroimage   Vol. 45 ( 1 ) page: 129-142   2009.3

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  69. Event-related potentials for gender discrimination: an examination between differences in gender discrimination between males and females. Reviewed

    Suyama N, Hoshiyama M, Shimizu H, Saito H.

    Int J Neurosci.   Vol. 118 ( 9 ) page: 1227-1237   2008.9

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  70. Evoked magnetic fields following noxious laser stimulation of the thigh in humans. Reviewed

    LinksNakata H, Tamura Y, Sakamoto K, Akatsuka K, Hirai M, Inui K, Hoshiyama M, Saitoh Y, Yamamoto T, Katayama Y, Kakigi R.

    Neuroimage   Vol. 42 ( 2 ) page: 858-868   2008.8

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  71. *Temporal dynamics of adaptation to natural sounds in the human auditory cortex. Reviewed

    Altmann CF, Nakata H, Noguchi Y, Inui K, Hoshiyama M, Kaneoke Y, Kakigi R.

    Cereb Cortex   Vol. 18 ( 6 ) page: 1350-1360   2008.6

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  72. Spatial contexts can inhibit a mislocalization of visual stimuli during smooth pursuit. Reviewed

    Noguchi Y, Shimojo S, Kakigi R, Hoshiyama M.

    J Vis   Vol. 7 ( 13 ) page: 1-15   2007.10

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  73. Objective examination for two-point stimulation using a somatosensory oddball paradigm: an MEG study. Reviewed

    Akatsuka K, Wasaka T, Nakata H, Kida T, Hoshiyama M, Tamura Y, Kakigi R.

    Clin Neurophysiol.     page: 118(2):403-11.   2007

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  74. Priority of repetitive adaptation to mismatch response following undiscriminable auditory stimulation: a magnetoencephalographic study. Reviewed

    Hoshiyama M, Okamoto H, Kakigi R.

    Eur J Neurosci.     page: 25(3):854-62.   2007

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  75. *Variability of P300 in elderly patients with dementia during a single day. Reviewed

    Uemura J, Hoshiyama M.

    Int J Rehabil Res.     page: 30(2):167-70.   2007

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  76. Voluntary attention changes the speed of perceptual neural processing. Reviewed

    Noguchi Y, Tanabe HC, Sadato N, Hoshiyama M, Kakigi R.

    Eur J Neurosci.     page: 25(10):3163-72   2007

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  77. Backward-masking: the effect of the duration of the second stimulus on recognition of the first stimulus. Reviewed

    Hashimoto A, Watanabe S, Inui K, Hoshiyama M, Murase S, Kakigi R.

    Neuroscience.     page: 137(4):1427-37   2006

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  78. Functional changes in cortical components of somatosensory evoked responses by stimulus repetition. Reviewed

    Hoshiyama M, Kakigi R.

    Clin Neurophysiol.     page: S59:149-57.   2006

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  79. Priority of face perception during subliminal stimulation using a new color-opponent flicker stimulation. Reviewed

    Hoshiyama M, Kakigi R, Takeshima Y, Miki K, Watanabe S.

    Neurosci Lett.     page: 402(1-2):57-61.   2006

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  80. Cognitive mechanism for meaning of emotive words in depressed personality: an event-related potential study. Reviewed

    Shimizu H, Saito H, Hoshiyama M.

    Nagoya J Med Sci.     page: 68(1-2):35-44.   2006

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  81. Characteristics of processing for trait adjectives in depressive persons: an event-related potential study. Reviewed

    Shimizu H, Saito H, Hoshiyama M.

    Nagoya J Med Sci.     page: 68(1-2):27-33.   2006

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  82. Differential priming effects of color-opponent subliminal stimulation on visual magnetic responses. Reviewed

    Hoshiyama M, Kakigi R, Takeshima Y, Miki K, Watanabe S.

    Hum Brain Mapp.     page: 27(10):811-8.   2006

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  83. 発声時の聴覚誘発反応

    軍司敦子, 柿木隆介, 宝珠山 稔

    臨床脳波     page: 48(6) : 355-359   2006

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  84. 意識閾値以下の顔刺激による脳反応

    寳珠山 稔, 柿木隆介

    臨床脳波     page: 48(8) : 468-473   2006

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  85. Functional relationship between human rolandic oscillations and motor cortical excitability: an MEG study. Reviewed

    Tamura Y, Hoshiyama M, Nakata H, Hiroe N, Inui K, Kaneoke Y, Inoue K, Kakigi R.

    Eur J Neurosci.     page: 21(9):2555-62.   2005

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  86. Mismatch responses related to temporal discrimination of somatosensory stimulation. Reviewed

    Akatsuka K, Wasaka T, Nakata H, Inui K, Hoshiyama M, Kakigi R.

    Clin Neurophysiol.     page: 116(8):1930-7.   2005

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  87. Face representation in the human secondary somatosensory cortex. Reviewed

    Nguyen BT, Inui K, Hoshiyama M, Nakata H, Kakigi R.

    Clin Neurophysiol.     page: 116(6):1247-53.   2005

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  88. 微小磁場計測装置を用いた末梢神経活動磁場の計測

    寳珠山稔, 柿木隆介

    臨床脳波     page: 47(4) : 215-220   2005

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  89. 調音をともなう発声時のヒト脳磁場反応

    軍司敦子, 柿木隆介, 宝珠山稔

    臨床脳波     page: 46(8) : 487-491   2004

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  90. Temporal discrimination threshold on various parts of the body. Reviewed

    Hoshiyama M, Kakigi R, Tamura Y.

    Muscle Nerve.     page: 29(2):243-7.   2004

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  91. Human brain processing and central mechanisms of pain as observed by electro- and magneto-encephalography. Reviewed

    Kakigi R, Inui K, Tran DT, Qiu Y, Wang X, Watanabe S, Hoshiyama M.

    J Chin Med Assoc.     page: 67(8):377-86   2004

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  92. Face representation in the human primary somatosensory cortex. Reviewed

    Nguyen BT, Tran TD, Hoshiyama M, Inui K, Kakigi R.

    Neurosci Res.     page: 50(2):227-32.   2004

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  93. Cognitive processes in two-point discrimination: an ERP study. Reviewed

    Tamura Y, Hoshiyama M, Inui K, Nakata H, Wasaka T, Ojima S, Inoue K, Kakigi R.

    Clin Neurophysiol.     page: 115(8):1875-84.   2004

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  94. Facilitation of A[delta]-fiber-mediated acute pain by repetitive transcranial magnetic stimulation. Reviewed

    Tamura Y, Hoshiyama M, Inui K, Nakata H, Qiu Y, Ugawa Y, Inoue K, Kakigi R.

    Neurology.     page: 62(12):2176-81.   2004

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  95. 正中神経刺激による体性感覚誘発電位のRecovery function-短時間Interstimulus intervalでの検討-

    宝珠山稔, 柿木隆介

    臨床脳波     page: 46(7) : 424-429   2004

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  96. 自己発声音に対する聴覚反応

    軍司敦子, 柿木隆介, 宝珠山稔

    日本生体磁気学会誌     page: 16(1) : 34-35   2003

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  97. A comparative magnetoencephalographic study of cortical activations evoked by noxious and innocuous somatosensory stimulations. Reviewed

    Inui K, Tran TD, Qiu Y, Wang X, Hoshiyama M, Kakigi R.

    Neuroscience.     page: 120(1):235-48   2003

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  98. Central mechanisms for two-point discrimination in humans. Reviewed

    Tamura Y, Hoshiyama M, Inui K, Kakigi R.

    Neurosci Lett.     page: 342(3):187-90   2003

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  99. Cerebral responses following stimulation of unmyelinated C-fibers in humans: electro- and magneto-encephalographic study. Reviewed

    Kakigi R, Tran TD, Qiu Y, Wang X, Nguyen TB, Inui K, Watanabe S, Hoshiyama M.

    Neurosci Res     page: 45(3):255-75   2003

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  100. Effects of sleep on pain-related somatosensory evoked potentials in humans. Reviewed

    Wang X, Inui K, Qiu Y, Hoshiyama M, Tran TD, Kakigi R.

    Neurosci Res.     page: 45(1):53-7   2003

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  101. 聴覚系高次脳機能の脳磁図

    宝珠山稔, 柿木隆介

    臨床脳波     page: 45(6) : 359-364   2003

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  102. 着脱可能な乗用車(タクシー)用移乗補助椅子の開発とその有効性

    原和子, 宝珠山稔, 渡辺崇史

    作業療法     page: 22 : 5600   2003

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  103. Brain responses for the subconscious recognition of faces. Reviewed

    Hoshiyama M, Kakigi R, Watanabe S, Miki K, Takeshima Y.

    Neurosci Res     page: 46(4):435-42   2003

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  104. Changes in somatosensory evoked responses by repetition of the median nerve stimulation. Reviewed

    Hoshiyama M, Kakigi R.

    Clin Neurophysiol.     page: 114(12):2251-7.   2003

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  105. Gating of somatosensory evoked magnetic fields during the preparatory period of self-initiated finger movement. Reviewed

    Wasaka T, Hoshiyama M, Nakata H, Nishihira Y, Kakigi R.

    Neuroimage.     page: 20(3):1830-8   2003

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  106. Sensory perception during sleep in humans: a magnetoencephalograhic study. Reviewed

    Kakigi R, Naka D, Okusa T, Wang X, Inui K, Qiu Y, Tran TD, Miki K, Tamura Y, Nguyen TB, Watanabe S, Hoshiyama M.

    Sleep Med.     page: 4(6):493-507   2003

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  107. Effect of tactile interference stimulation of the ear in human primary somatosensory cortex: a magnetoencephalographic study. Reviewed

    Nihashi T, Kakigi R, Hoshiyama M, Miki K, Kajita Y, Yoshida J, Yatsuya H.

    Clin Neurophysiol.     page: 114(10):1866-78.   2003

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  108. Electrical-induced pain diminishes somatosensory evoked magnetic cortical fields. Reviewed

    Tran TD, Hoshiyama M, Inui K, Kakigi R.

    Clin Neurophysiol     page: 114(9):1704-14   2003

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  109. Cortical activities relating to modulation of sound frequency: how to vocalize? Reviewed

    Gunji A, Kakigi R, Hoshiyama M. Related Articles, Links

    Brain Res Cogn Brain Res.     page: 17(2):495-506   2003

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  110. Effects of sleep on pain-related somatosensory evoked magnetic fields in humans. Reviewed

    Wang X, Inui K, Qiu Y, Hoshiyama M, Tran TD, Nguyen TB, Kakigi R.

    Brain Res Cogn Brain Res     page: 17(2):388-99   2003

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  111. 痛覚関連体性感覚誘発脳磁場に対する睡眠の影響

    王暁宏, 乾幸二, 秋雲海, 宝珠山稔, Tuan Diep Tran, 柿木隆介

    日本生体磁気学会誌     page: 15(1) : 159-160   2002

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  112. Cerebral activation by the signals ascending through unmyelinated C-fibers in humans: a magnetoencephalographic study. Reviewed

    Tran TD, Inui K, Hoshiyama M, Lam K, Qiu Y, Kakigi R.

    Neuroscience     page: 113(2):375-86   2002

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  113. 痛覚認知機能の生理学的研究

    柿木隆介, 乾幸二, 宝珠山稔, 渡辺昌子, Tran Diep Tuan, 秋云海, 王暁宏

    麻酔     page: 51 : 5115-5124   2002

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  114. 正中神経刺激による短潜時体性感覚誘発脳磁界と脳電位の対応

    宝珠山稔, 柿木隆介

    臨床脳波     page: 44(2) : 91-96   2002

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  115. 痛覚関連脳冒位と皮膚刺激領域との関連について Reviewed

    堀内万起子, 猪田邦雄, 宝珠山稔

    理学療法の医学的基礎     page: 6(1) : 24   2002

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  116. 表皮内電気刺激法による痛覚関連誘発脳磁場

    乾幸二, Tuan Diep Tran, 秋雲海, 王暁宏, 宝珠山稔, 柿木隆介

    日本生体磁気学会誌     page: 15(1) : 101-102   2002

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  117. Conduction velocity of the spinothalamic tract following CO2 laser stimulation of C-fibers in humans. Reviewed

    Tran TD, Inui K, Hoshiyama M, Lam K, Kakigi R.

    Pain     page: 95(1-2):125-31.   2002

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  118. Preferential stimulation of Adelta fibers by intra-epidermal needle electrode in humans. Reviewed

    Inui K, Tran TD, Hoshiyama M, Kakigi R.

    Pain     page: 96(3):247-52   2002

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  119. New concept for the recovery function of short-latency somatosensory evoked cortical potentials following median nerve stimulation. Reviewed

    Hoshiyama M, Kakigi R.

    Clin Neurophysiol.     page: 113(4):535-41.   2002

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  120. Pain-related magnetic fields evoked by intra-epidermal electrical stimulation in humans. Reviewed

    Inui K, Tran TD, Qiu Y, Wang X, Hoshiyama M, Kakigi R.

    Clin Neurophysiol.     page: 113(2):298-304.   2002

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  121. 音想起に関する脳内活動の脳磁場解析

    宝珠山稔、軍司敦子, 柿木隆介

    日本生体磁気学会誌     page: 14(1) : 96-97   2001

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  122. 耳の第一次体性感覚野における受容野の検討

    二橋尚志, 柿木隆介, 宝珠山稔, 梶田泰一, 吉田純

    臨床脳波     page: 43(9) : 577-582   2001

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  123. Representation of the ear in human primary somatosensory cortex. Reviewed

    Nihashi T, Kakigi R, Kawakami O, Hoshiyama M, Itomi K, Nakanishi H, Kajita Y, Inao S, Yoshida J.

    Neuroimage.     page: 13(2):295-304.   2001

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  124. A unique area of the homonculus: the topography of the primary somatosensory cortex in humans following posterior scalp and shoulder stimulation. Reviewed

    Itomi K, Kakigi R, Hoshiyama M, Watanabe K.

    Brain Topogr     page: 14(1):15-23.   2001

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  125. Effects of attention on pattern-reversal visual evoked potentials: foveal field stimulation versus peripheral field stimulation. Reviewed

    Hoshiyama M, Kakigi R.

    Brain Topogr.     page: 13(4):293-8   2001

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  126. Two evoked responses with different recovery functions in the primary somatosensory cortex in humans. Reviewed

    Hoshiyama M, Kakigi R.

    Clin Neurophysiol.     page: 112(7):1334-42   2001

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  127. Neural activities during Wisconsin Card Sorting Test--MEG observation. Reviewed

    Wang L, Kakigi R, Hoshiyama M.

    Brain Res Cogn Brain Res     page: 12(1):19-31.   2001

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  128. Correspondence between short-latency somatosensory evoked brain potentials and cortical magnetic fields following median nerve stimulation. Reviewed

    Hoshiyama M, Kakigi R.

    Brain Res.     page: 908(2):140-8.   2001

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  129. Hearing the sound of silence: a magnetoencephalographic study. Reviewed

    Hoshiyama M, Gunji A, Kakigi R.

    Neuroreport     page: 12(6):1097-102   2001

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  130. A new method for measuring the conduction velocities of Abeta-, Adelta- and C-fibers following electric and CO(2) laser stimulation in humans.. 2001 Apr 6; Reviewed

    Tran TD, Lam K, Hoshiyama M, Kakigi R.

    Neurosci Lett     page: 301(3):187-90.   2001

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  131. Auditory response following vocalization: a magnetoencephalographic study. Reviewed

    Gunji A, Hoshiyama M, Kakigi R.

    Clin Neurophysiol     page: 112(3):514-20.   2001

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  132. 聴覚マスキング条件下の発声関連脳磁場

    軍司敦子, 宝珠山稔, 柿木隆介

    日本生体磁気学会誌     page: 13(1) : 222-223   2000

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  133. Transcutaneous electrical nerve stimulation(TENS)後の痛覚関連脳反応の変化

    柿木隆介,宝珠山稔

    PAIN RESEARCH     page: 15(3) : 155   2000

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  134. 耳電気刺激による体性感覚誘発脳磁界反応

    二橋尚志, 柿木隆介, 川上治, 宝珠山稔, 梶田泰一, 稲尾意秀, 吉田純

    日本生体磁気学会誌     page: 13(1) : 182-183   2000

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  135. 後頚部、肩部の体性感覚誘発脳磁図

    糸見和也, 柿木隆介, 宝珠山稔

    日本生体磁気学会誌     page: 13(1) : 184-185   2000

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  136. Identification of auditory evoked potentials of one's own voice. Reviewed

    Gunji A, Hoshiyama M, Kakigi R.

    Clinical Neurophysiology     page: 111,2,214-219   2000

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  137. Dermatome versus homunculus; detailed topography of the primary somatosensory cortex following trunk stimulation. Reviewed

    Itomi K, Kakigi R, Maeda K, Hoshiyama M.

    Clinical Neurophysiology     page: 111,3,405-12   2000

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  138. Vibratory stimulation of proximal muscles does not affect cortical components of somatosensory evoked potential following distal nerve stimulation. Reviewed

        page: 111(9):1607-10   2000

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  139. Effects of check size on pattern reversal visual evoked magnetic field and potential. Reviewed

    Nakamura M, Kakigi R, Okusa T, Hoshiyama M, Watanabe K.

    Brain Res     page: 28;872(1-2):77-86.   2000

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  140. The somatosensory evoked magnetic fields. Reviewed

    Kakigi R, Hoshiyama M, Shimojo M, Naka D, Yamasaki H, Watanabe S, Xiang J, Maeda K, Lam K, Itomi K, Nakamura A.

    Prog Neurobiol     page: 61(5):495-523   2000

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  141. Effects of distraction on pain-related somatosensory evoked magnetic fields and potentials following painful electrical stimulation. Reviewed

    Yamasaki H, Kakigi R, Watanabe S, Hoshiyama M.

    Brain Res Cogn Brain Res     page: 9(2):165-75.   2000

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  142. Spatiotemporal source analysis of vocalization-associated magnetic fields. Reviewed

    Gunji A, Kakigi R, Hoshiyama M.

    Brain Res Cogn Brain Res     page: 9,2,157-163   2000

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  143. After-effect of transcutaneous electrical nerve stimulation (TENS) on pain-related evoked potentials and magnetic fields in normal subjects. Reviewed

    Hoshiyama M, Kakigi R.

    Clinical Neurophysiology     page: 111,4,717-724   2000

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  144. 電気刺激による痛覚関連脳磁場に対する注意効果

    山崎浩, 柿木隆介, 宝珠山稔

    日本生体磁気学会誌     page: 12(1) : 42-43   1999

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  145. 随伴陰性変動課題におけるcortical silent periodの変化

    宝珠山稔,柿木隆介

    臨床脳波     page: 41(11) : 713-717   1999

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  146. Peripheral nerve conduction study by small multi-channel gradiometers(micro-SQUID).

    Neuroscience Letters   Vol. 272   page: 199-202   1999

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  147. Structure of the auditory evoked magnetic fields during sleep. Reviewed

    Neuroscience   Vol. 93 ( 2 ) page: 573-783   1999

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  148. Shortening of the cortical silent period following transcranial wagnetic brain stimulation during an experimental paradigm for generating contingent negative variation(CNV).

    Electroencephalography and Clinical Neurophysiology   Vol. 110   page: 1394-1398   1999

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  149. Changes of somatoseusory evoked potentials(SEP)during writing with dominant and non-aominant hands.

    Brain Research   Vol. 833   page: 10-19   1999

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  150. Topography of the secondary somatosensory cortex in humans: a magnetoencephalo-graphic study.Neuroreport. Reviewed

    NeuroReport   Vol. 10 ( 2 ) page: 301-306   1999

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  151. Pain processing traced by magnetoencephalography in the human brain.

    Brain Topography   Vol. 10   page: 255-246   1998

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  152. Visual evoked magnetic responses to central and peripheral stimulation : simultaneous VEP recordings.

    Brain topography   Vol. 10   page: 227-237   1998

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  153. Changes of somatosensory evoked potentials preceding rapid voluntary movement in GO/No-go choice reaction time task.

    Brain Research, Cognitive Brain Research   Vol. 7   page: 137-142   1998

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  154. Reading of Japanese Kanji (morphograms) and Kana (syllabogram) : a magnetoencephalographic study.

    Neuropsychologica   Vol. 36   page: 83-98   1998

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  155. Somatosensory evoked magnetic fields following passive finger movement.

    Brain Research, Cognitive brain research   Vol. 6   page: 73-82   1997

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  156. Odorant evoked magnetic fields in humans.

    Neuroscience Research   Vol. 27   page: 115-122   1997

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  157. Visual evoked cortical magnetic fields to pattern reversal stimulation.

    Brain Research, Cognitive Brain Research   Vol. 6   page: 9-22   1997

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  158. Identification of motor and sensory brain actiivities during unilateral finger movement : spatio-temporal source analysis of movement-associated magnetic fields.

    Experimental Brain Research   Vol. 115   page: 6-14   1997

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  159. Temporal changes of pyramidal tract activities after decision of movement : a study using transcranial magnetic stimulation of the motor cortex in humans.

    Electroencephalography and Clinical Neurophysiology   Vol. 105   page: 255-261   1997

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  160. Effects of movement and movement imagery on somatosensory evoked magnetic fields following posterior tibial nerve stimulation.

    Brain Research, Cognitive brain Research   Vol. 5   page: 241-253   1997

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  161. Magnetoencephalographic study of intracerebral interactions caused by bilateral posterior tibial nerve stimulation in man.

    Neuroscience Research   Vol. 28   page: 41-47   1997

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  162. Smoatosensory magnetic fields and potentials following passive toe movement in humans.

    Electroencephalography and Clinical Neurophysiology   Vol. 104   page: 393-401   1997

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  163. Activity in posterior parietal cortex following somatosensory stimulation in man : magnetoencephalographic study using spatio-temporal source analysis.

    Brain Topography   Vol. 10   page: 23-30   1997

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  164. ヒトの痛覚認知に及ぼす侵害的冷覚刺激の影響

    渡邊昌子,柿木隆介,宝珠山稔,北村吉宏,小山幸子,下条素子

    臨床脳波     page: 38(10) : 679-685,   1996

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  165. 生理学的手法(脳磁図・脳波)を用いたヒト脳機能の非侵襲的研究

    柿木隆介,宝珠山稔,小山幸子,北村吉宏,下条素子,渡邊昌子

    インナービジョン     page: 11(8) : 24,   1996

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    Language:Japanese  

  166. Differentiation of receptive fields in the sensory cortex following various areas of the lower limb in humans : a magnetoencephalographic study.

    Journal of Neurosurgery   Vol. 85   page: 255-262   1996

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  167. Topography of somatosensory evoked magnetic fields following posterior tibial nerve stimulation.

    Electroencephalography and Clinical Neurophysiology   Vol. 95   page: 127-134   1996

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  168. Pain-related somatosensory evoked magnetc fields following lower limb stimulation.

    Electroencephalography and Clinical Neurophysiology   Vol. 145   page: 187-194   1996

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  169. Effects of noxious cooling of the skin on pain perception in man.

    Journal of Neurological Sciences   Vol. 135   page: 68-73   1996

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  170. Somatosensory evoked magnetic fields following stimulation of the lip in humans.

    Electroencephalography and Clinical Neurophysiology   Vol. 96   page: 96-104   1996

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  171. Reciprocal changes of motor evoked potential preceding voluntary movement.

    Muscle and Nerve   Vol. 19   page: 125-131   1996

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  172. Effects of tactile interference stimulation on somatosensory evoked magnetic fields.

    Neuro Report   Vol. 7   page: 405-408   1996

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  173. Effects of judgment process on motor evoked potentials in Go/No-go hand movement task.

    Neuroscience Research   Vol. 24   page: 427-430   1996

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  174. Pain related responses following CO2 laserstimulation : magnetoencephalographic studies.

    Electroencephalography and Clinical Neurophysiology   Vol. 47   page: 111-120   1996

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  175. Effects of sleep on somatosensory evoked responses in humans : a magnetoencephalographic study.

    Brain Resaerch, Cognitive Brain Research   Vol. 4   page: 275-279   1996

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  176. Intracerebral interactions caused by bilateral median nerve stimulation in man : a magnetoencephalographic study.

    Neuroscience Research   Vol. 24   page: 175-181   1996

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  177. Pain-related somatosensory evoked magnetic fields.

    Electroencephalography and Clinical Neurophysiology   Vol. 95   page: 463-474   1995

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  178. Gating of somatosernsory evoked responses during active finger movements : magnetoencephalographic studies.

    Journal of Neurological Sciences   Vol. 128   page: 195-204   1995

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  179. Pain-related magnetic fields following painful CO2 laser stimulation in man.

    Neuroscience Letters   Vol. 192   page: 45-48   1995

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  180. Somatosensory evoked magnetic fields following mechanical stimulation of the scalp in humans.

    Neuroscience Letters   Vol. 195   page: 29-32   1995

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  181. Effect of Optokinetic stimulation on the Hneflex in humans

    Japanese Journal of Physiology   Vol. 44   page: 67-73   1994

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  182. Hypokinesia of associated movement in Parkinson's disease : a symptom in early stapes of the disease

    Journal of Neunology   Vol. 241   page: 517-521   1994

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  183. 血管破壊性リンパ腫およびneoplastic angioendotheliosis様の浸潤形態をとった悪性リンパ腫の一例 Reviewed

    谷田部恭, 中川温子, 橋詰良夫, 竹内有子, 広瀬善清, 宝珠山稔, 森尚義, 浅井淳平

    現代医学     page: 41(2) : 375-380   1993

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  184. Effect of optokinetic stimulation on human balance recovery in unexpected forward fall.

    Neunoscieuce Research   Vol. 18   page: 121-127   1993

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  185. Modulation of human balanciup recovery in forward fall by optokinetic stimulation Reviewed

    Environmental Medicine   Vol. 36   page: 191-194   1992

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Books 2

  1. Spatio-temporal source analysis of movement associated magnetic fields.

    Brain Topography, Elsevier, Amsterdam  1998 

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  2. Clinical evaluation of Brain Damape by Proton density dynamics

    Advance in Brain Resustation  1991 

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    Language:English

MISC 1

  1. 安静時脳磁図ネットワークの加齢性変化の検討

    加藤 隼康, 渡辺 宏久, 大嶽 れい子, 蝦名 潤哉, 吉田 有佑, 小倉 礼, 川畑 和也, 桝田 道人, 原 一洋, 寳珠山 稔, 勝野 雅央, 祖父江 元

    臨床神経学   Vol. 59 ( Suppl. ) page: S318 - S318   2019.11

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    Language:Japanese   Publisher:(一社)日本神経学会  

Presentations 4

  1. 体性感覚誘発電位(SEP)

    寳珠山 稔

    第40回日本臨床神経生理学会学術大会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

    SEP の特性、記録のしかた、反応成分の意味についての教育講演。

  2. Two-point discrimination: evaluation using neurophysiological methods

    29th International Congress of Clinical Neurophysiology 

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    Event date: 2010.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

    Cognitive mechanisms for two-point discrimination (TPD) were investigated,
    using new methods of stimulation and evoked potentials.
    (1) Electrical two-point stimulation. Using six ball-shaped electrodes
    placed in line on the dorsal surface of a hand, two points were electrically
    stimulation at a time. The reaction time for TPD was measured for each
    two-point stimulation. The subjects' responses were significantly affected
    by the preceding stimuli as well as the distance of the stimuli: for

  3. Feature binding in the ventral visual pathway revealed bycolor-motion misbinding

    29th International Congress of Clinical Neurophysiology 

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    Event date: 2010.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

    Objective: Mounting evidence indicates that visual features such as
    shape, color, and motion are processed in specialized regions of the
    brain, while these features are coherently integrated in our conscious
    experiences. How our brain links the features associated with the same
    object is an important problem in neuroscience. Previous studies have
    indicated a critical role of top-down attention in integrating features
    and thus reported an involvement of the dorsal pathway of the visual
    pro

  4. 顔刺激による誘発脳反応の成分とその優位性について

    寳珠山 稔

    日本顔学会「顔学フォーラム2007」 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

KAKENHI (Grants-in-Aid for Scientific Research) 17

  1. Development of evaluation method for chronic pain and brain network dysfunction

    Grant number:20K07881  2020.4 - 2023.3

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  2. 脳機能解析を応用した疼痛評価システムの開発

    Grant number:19K09647  2019.4 - 2022.3

    岩月 克之

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    神経障害性疼痛中枢性感作の病態を解明し、臨床データ、患者立脚型機能評価等を脳機能解析と組み合わせ、客観的な重症度評価を行う。さらに発展させ、一般病院で使用している機器で測定可能なパラメータを利用することにより、臨床の汎用性が生まれる。本研究の目的は、疼痛の種類・重症度別にパターン化可能な客観的指標の解析を行い、最終的には一般病院に還元可能な疼痛評価法およびそのシステムを構築することである。本研究により信頼性の高い疼痛研究の手法が確立でき、病態解明、臨床評価、治療効果判定までが可能となり、疼痛分野における研究を飛躍的に向上できる。
    神経障害性疼痛の患者として手根管症候群の患者を登録して解析を行っている。他難治性疼痛である複合性局所疼痛症候群患者なども登録し解析を行っている。
    手根管症候群においては、手術前および手根管開放後半年での脳磁図検査を解析した。母指および中指の皮膚電気刺激によって得られる体性感覚誘発脳磁場(SEF)の推定電流源間距離を比較した。また正中神経を手関節部で電気刺激しSEFを計測した。単発刺激に加え10, 40, 80, 200 msの刺激間隔(ISI)の2発刺激により誘発されたSEFより刺激後20msに出現するSEF成分(N20m)の振幅(RMS)の回復曲線を算出し、年齢対照群における値と比較した。
    正中神経の皮膚感覚支配領域からの感覚入力が障害されるため、対応する皮質受容野内での機能構築が不明瞭となり、母指中指の皮膚電気刺激によって得られるSEFの推定電流源間距離は手根管症候群で年齢対照群より短く、電気生理学的重症度と相関していた。しかし術後半年でこの変化は健常群に近い距離に回復していた。
    また10 ms間隔刺激により得られるSEFの回復曲線は手根管症候群で早期の回復が認められ、電気生理学的中等度群は重症度群と比較して早期の回復であった。特に中等度群で感覚皮質での抑制的神経活動が減少していることが示唆された。しかしこの変化は術後半年でほとんど回復はしなかった。
    皮質受容野内で機能構築が不明瞭となる事は神経障害における不適合性変化であり、障害が改善すると元に戻る。一方、感覚皮質での抑制的神経活動の減少は、知覚低下に伴う適合性変化とも考えられ、手術後においても刺激に対する脱抑制は比較的長時間にわたり残存している可能性がある。さらに中程度群で、脳が回復機能と適応変化に対する感度を高めようとしているが、重症だとそれもできなくなるという可能性が考えられた。
    昨年末までは順調に研究を遂行可能であった。年度末にかけて新型コロナウイルスの問題が生じてやや研究遂行が減速はしている。
    今年度に引き続き疼痛における脳機能解析を行っていく予定である。昨年度末にかけて新型コロナウイルスの問題が生じ、今後の研究に問題が生じる可能性も懸念はしている。

  3. Connectome map for epilepsy surgery originated by network imaging analysis and its justification by stereotactic electroencephalography (SEEG)

    Grant number:17K10890  2017.4 - 2020.3

    Maesawa Satoshi

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    The purpose of this study was to evaluate epileptogenic networks in focal epilepsy using novel modalities such as rsfMRI, MEG, and EEG-fMRI, create the connectome map, and justify with stereotactic electroencephalography (SEEG). Multilayer analysis with rsfMRI revealed epileptogenic hubs near the focus with excitatory connection to the contralateral hubs and inhibitory connections to the default mode network, and this may reflect pathological mechanism in focal epilepsy. Modified DS(distributed source) analysis in MEG and subsecond analysis in EEG-fMRI improved detection of epileptic focus and its networks. Novel metrics for demonstrating connectivity to canonical networks were created, and used as a connectome map. SEEG analyzed with coherence showed relationship between epileptic focus and its networks.

  4. Pathological elucidation of tremor by various modality and modification by Focal Ultrasounds and Deep Brain Stimulation

    Grant number:17K10891  2017.4 - 2020.3

    Nakatsubo Daisuke

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    MRgFUS (MR-guided focused ultrasound) has become possible in Japan as a non-invasive coagulation therapy for the treatment of involuntary movements such as essential tremor. In this study, the improvement rate of the upper limbs was about 65% one year after treatment, and no serious complications were observed. In addition, network analysis by resting fMRI revealed that the more severe the tremor, the lower the connectivity of the network, and the higher brain function mainly in the frontal lobe is also impaired.

  5. 脳磁計を用いた安静時および刺激誘発脳活動における脳内神経接続の測定に関する研究

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(C)

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  6. 脳磁計を用いた安静時および刺激誘発脳活動における脳内神経接続の測定に関する研究

    2015.4 - 2018.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Competitive

  7. The inhibitory change using double stimulation somatosensory evoked response in aging and Parkinsonian effects

    Grant number:15K09350  2015.4 - 2018.3

    Masaaki Hirayama

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    Somatosensory evoked cerebral magnetic field (SEF) was measured in elderly healthy subjects and PD, and the recurrent curve was measured. Measurement of 80 ms repetitive suppression at one second intervals between healthy elderly and PD and young group was measured. The current was estimated by continuous stimulation twice with a constant current of 0.2 ms. There was a significant difference in the first and second wave between the young and the elderly. In PD and elderly people, the response of the first wave and second wave was different in suppression pattern between elderly group and PD. the recovery function by aging change was less suppression of the first wave in the elder group. On the other hand, recovery of the second wave was facilitated in the senior group. The first and second components are different in recovery function and change by aging. In patients with PD, it was suggested that the disorder of suppression mechanism associated with aging was dissociated.

  8. Evaluatuin for pain with brain function and SNP analysis

    Grant number:15K10400  2015.4 - 2018.3

    Iwatsuki Katsuyuki

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    The recovery function of somatosensory evoked magnetic fields was recorded to investigate excitatory and inhibitory balance in the somatosensory cortex of patients with carpal tunnel syndrome. Distances on the vertical axis between the equivalent current dipoles for the first and third digits were shorter in patients than in control participants. The root mean square for the N20m recovered earlier in patients compared to controls; this was statistically significant at an interstimulus interval of 10 ms. Coherence value was analyzed in the measurement population including carpal tunnel syndrome, complex regional pain syndrome patients, and healthy subjects. Coherence value showed significant differences between these patients and healthy controls.

  9. Measurement of neural connectivity at rest and during tasks by magnetoencephalography system

    Grant number:15K09349  2015.4 - 2018.3

    Hoshiyama Minoru

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    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    Resting and task-related magnetic cortical fields were measured by a magnetoencephalographic system (MEG), and inter-cortical connectivity was analyzed in physiological and pathological conditions. Change in neural connectivity during somatosensory, auditory, and motor tasks were calculated using latest methods, dipole distribution and coherence/correlation analyses, in healthy subjects. Pathological neural connectivity was investigated in patients with peripheral neuropathy, such as median nerve neuropathy at the wrist, and in patients with central nervous system. Parkinson’s disease. Present series of study resulted in 11 papers published in international journals. We believe that methods for analyzing inter-cortical connectivity during tasks and at rest have been established during our studies. Our methods could be applied to analysis using clinical electroencephalography recording. Application to clinical examination might be possible.

  10. 非侵襲的生理学的手法による大脳内神経伝導に関する研究

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C), 課題番号:24591292

    寳珠山 稔

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  11. Neurophysiological sand pathophysiological studies of the human brain function of sensory processing

    2002.4 - 2004.3

    Grant-in-Aid for Scientific Research 

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  12. Neurophysiological studies of the human brain concerning the functional recovery using non-invasive Techniques

    2000.4 - 2002.3

    Grant-in-Aid for Scientific Research 

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  13. Neurophysiological study of motor control mechanisms of human brain

    1998.4 - 2000.3

    Grant-in-Aid for Scientific Research 

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    Authorship:Principal investigator 

  14. 大型及び超小型磁場計測装置を用いたヒト高次脳機能の研究

    1998.4 - 1999.3

    科学研究費補助金  特定領域研究(A), 課題番号:10164246

    柿木隆介

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  15. 脳磁図を用いたヒト痛覚認知機構の研究

    1996.4 - 1999.3

    科学研究費補助金  萌芽的研究, 課題番号:08878160

    柿木 隆介

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  16. NON-INVASIVE STUDY OF HUMAN BRAIN FUNCTION USING PHYSIOLOGICAL METHODS,MAGNETOENCEPHALOGRAPHY AND ELECTROENCEPHALOGRAPHY

    1995.4 - 1997.3

    Grant-in-Aid for Scientific Research 

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    Authorship:Coinvestigator(s) 

  17. 生理学的手法(脳磁図,脳波,誘発筋電図)を用いた随意運動発現機構に関する研究

    1995.4 - 1996.3

    科学研究費補助金  奨励研究(A), 課題番号:07770485

    寳珠山 稔

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Teaching Experience (On-campus) 1

  1. Laboratory in Biology

    2011