Updated on 2022/04/19

写真a

 
NADANO, Daita
 
Organization
Graduate School of Bioagricultural Sciences Department of Applied Biosciences Associate professor
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences
Title
Associate professor

Degree 1

  1. Ph.D. ( 1993.6   Fukui Medical University ) 

Research Areas 2

  1. Life Science / Applied biochemistry  / Applied Biochemistry

  2. Life Science / Applied molecular and cellular biology  / Applied Molecular Cell Biology

Current Research Project and SDGs 2

  1. Analysis of the control mechanisms of translation (protein synthesis) in the higher animals

  2. Molecular mechanism of mammary gland involution

Research History 7

  1. 名古屋大学大学院生命農学研究科 准教授(職名変更)

    2007.4

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    Country:Japan

  2. "Nagoya University, Graduate School of Bioagricultural Sciences, Associate Professor"

    2001.9 - 2007.3

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    Country:Japan

  3. "RIKEN, Molecular Oncology Laboratory, Senior Research Scientist"

    2000.4 - 2001.8

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    Country:Japan

  4. "RIKEN, Molecular Oncology Laboratory, Contact Researcher"

    1998.10 - 2000.3

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    Country:Japan

  5. "the Burnham Institute, Research Fellow"

    1996.4 - 1998.9

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    Country:United States

  6. "Fukui Medical School, Department of Legal Medicine, Research Assistant"

    1990.4 - 1996.4

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    Country:Japan

  7. "National Institute of Police Science, Researcher"

    1986.4 - 1990.3

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    Country:Japan

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Education 2

  1. The University of Tokyo   Graduate School, Division of Science   Department of Biophysics and Biochemistry

    - 1986

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    Country: Japan

  2. The University of Tokyo   Faculty of Science   Department of Biophysics and Biochemistry

    - 1984

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    Country: Japan

Professional Memberships 4

  1. Japan Society for Bioscience, Biotechnology, and Agrochemistry

  2. Molecular Biology Society of Japan

  3. Japanese Biochemical Society

  4. Japanese Cancer Association

 

Papers 104

  1. Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain

    Sugitani Kei, Egorova Diana, Mizumoto Shuji, Nishio Shunsuke, Yamada Shuhei, Kitagawa Hiroshi, Oshima Kenzi, Nadano Daita, Matsuda Tsukasa, Miyata Shinji

    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS   Vol. 1865 ( 2 ) page: 129804   2021.2

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  2. A pericellular hyaluronan matrix is required for the morphological maturation of cortical neurons

    Takechi Mina, Oshima Kenzi, Nadano Daita, Kitagawa Hiroshi, Matsuda Tsukasa, Miyata Shinji

    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS   Vol. 1864 ( 10 ) page: 129679   2020.10

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  3. Transcription Factor Sox4 as a Potential Player in Mammary Gland Involution

    Shibayama Hirohisa, Yamamoto Tomomi, Oshima Kenzi, Matsuda Tsukasa, Nadano Daita

    DNA AND CELL BIOLOGY   Vol. 38 ( 10 ) page: 1125 - 1133   2019.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/dna.2019.4700

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  4. Apical-to-basolateral transepithelial transport of cow's milk caseins by intestinal Caco-2 cell monolayers: MS-based quantitation of cellularly degraded alpha- and beta-casein fragments

    Sakurai Nao, Nishio Shunsuke, Akiyama Yuka, Miyata Shinji, Oshima Kenzi, Nadano Daita, Matsuda Tsukasa

    JOURNAL OF BIOCHEMISTRY   Vol. 164 ( 2 ) page: 113-125   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jb/mvy034

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  5. The mRNA-binding protein Serbp1 as an auxiliary protein associated with mammalian cytoplasmic ribosomes

    Muto Akiko, Sugihara Yoshihiko, Shibakawa Minami, Oshima Kenzi, Matsuda Tsukasa, Nadano Daita

    CELL BIOCHEMISTRY AND FUNCTION   Vol. 36 ( 6 ) page: 312-322   2018.8

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    DOI: 10.1002/cbf.3350

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  6. Extracellular vesicle-mediated MFG-E8 localization in the extracellular matrix is required for its integrin-dependent function in mouse mammary epithelial cells

    Ooishi Takuya, Nadano Daita, Matsuda Tsukasa, Oshima Kenzi

    GENES TO CELLS   Vol. 22 ( 10 ) page: 885-899   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12521

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  7. RPL10L Is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice

    Jiang Long, Li Tao, Zhang Xingxia, Zhang Beibei, Yu Changping, Li Yang, Fan Suixing, Jiang Xiaohua, Khan Teka, Hao Qiaomei, Xu Peng, Nadano Daita, Huleihel Mahmoud, Lunenfeld Eitan, Wang P. Jeremy, Zhang Yuanwei, Shi Qinghua

    CURRENT BIOLOGY   Vol. 27 ( 10 ) page: 1498-+   2017.5

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    DOI: 10.1016/j.cub.2017.04.017

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  8. Evaluation of allergenic potential for rice seed protein components utilizing a rice proteome database and an allergen database in combination with IgE-binding of recombinant proteins Reviewed

    Hirano, K., Hino, S., Oshima, K., Nadano, D., Urisu, A., Takaiwa, F., and Matsuda, T.

    Biosci. Biotechnol. Biochem.   Vol. 80 ( 3 ) page: 564-573   2016.3

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  9. A protective effect of milk-fat globule EGF factor VIII (MFG-E8) on the spontaneous fusion of milk fat globules in breast milk. Reviewed

    Yasueda, T., Oshima, K., Nakatani, H., Tabuchi, K., Nadano, D., and Matsuda, T.

    J. Biochem.   Vol. 158 ( 1 ) page: 25-35   2015.7

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  10. Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated epidermal growth factor (EGF) domain-specific O-Linked N-acetylglucosamine transferase found in Adams-Oliver syndrome. Reviewed

    Ogawa, M., Sawaguchi, S., Kawai, T., Nadano, D., Matsuda, T., Yagi, H., Kato, K., Furukawa, K., and Okajima, T.

    J. Biol. Chem.   Vol. 290 ( 4 ) page: 2137-2149   2015.1

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  11. Glycosylated Chicken ZP2 Accumulates in the Egg Coat of Immature Oocytes and Remains Localized to the Germinal Disc Region of Mature Eggs. Reviewed

    Nishio, S., Kohno, Y., Iwata, Y., Arai, M., Okumura, H., Oshima, K., Nadano, D., and Matsuda, T.

    Biol Reprod.   Vol. 91 ( 5 ) page: 107, 1-10   2014.11

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  12. Lyar, a cell growth-regulating zinc finger protein, was identified to be associated with cytoplasmic ribosomes in male germ and cancer cells. Reviewed

    Yonezawa, K., Sugihara, Y., Oshima, K., Matsuda, T., and Nadano, D.

    Mol. Cell. Biochem.   Vol. 395 ( 1-2 ) page: 221-229   2014.10

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  13. A lactoferrin-receptor, intelectin 1, affects uptake, sub-cellular localization and release of immunochemically detectable lactoferrin by intestinal epithelial Caco-2 cells. Reviewed

    Akiyama Y, Oshima K, Kuhara T, Shin K, Abe F, Iwatsuki K, Nadano D, Matsuda T

      Vol. 154 ( 2 ) page: 437-448   2013.11

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  14. Allergenic potential of rice-pollen proteins: expression, immuno-cross reactivity and IgE-binding. Reviewed

    Hirano K, Hino S, Oshima K, Okajima T, Nadano D, Urisu A, Takaiwa F, Matsuda T

    J Biochem.   Vol. 154 ( 2 ) page: 195-205   2013.8

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  15. Identification and expression of an autosomal paralogue of ribosomal protein S4, X-linked, in mice: Potential involvement of testis-specific ribosomal proteins in translation and spermatogenesis. Reviewed

    Sugihara, Y., Sadohara, E., Yonezawa, K., Kugo, M., Oshima, K., Matsuda, T., and Nadano, D.

    Gene   Vol. 521 ( 1 ) page: 91-99   2013.5

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  16. Intracellular retention and subsequent release of bovine milk lactoferrin taken up by human enterocyte-like cell lines, Caco-2, C2BBe1 and HT-29. Reviewed

    Akiyama Y, Oshima K, Shin K, Wakabayashi H, Abe F, Nadano D, Matsuda T.

    Biosci. Biotechnol. Biochem.   Vol. 77 ( 5 ) page: 1023-1029   2013.5

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  17. Post-weaning increases in the milk-fat globule EGF-factor VIII on fat globules in mouse milk and in the uptake of the fat globules by HC11 mammary epithelial cells. Reviewed

    Nakatani H, Yasueda T, Oshima K, Okajima T, Nadano D, Flint DJ, Matsuda T.

      Vol. 153 ( 1 ) page: 31-41   2013.1

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  18. Enhancement of mouse sperm motility by trophinin-binding peptide. Reviewed

    Park SK, Yoon J, Wang L, Shibata TK, Motamedchaboki K, Shim KJ, Chang MS, Lee SH, Tamura N, Hatakeyama S, Nadano D, Sugihara K, Fukuda MN.

    Reprod. Biol. Endocrinol.   Vol. 10 ( 1 ) page: 101   2012.11

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    DOI: 10.1186/1477-7827-10-101

  19. Re-evaluation of milk-fat globule EGF-Factor VIII (MFG-E8) as an intrinsic component on the mouse milk-fat globule membrane. Reviewed

    Nakatani, H., Yasueda, T., Oshima, K., Nadano, D., Flint, D., and Matsuda T.

    Biosci. Biotech. Biochem.   Vol. 76 ( 11 ) page: 2055-2060   2012.11

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  20. The murine Gcap14 gene encodes a novel microtubule binding and bundling protein. Reviewed

    Hosono, H., Yamaguchi, N., Oshima, K., Matsuda, T., and Nadano, D.

    FEBS Lett.   Vol. 586 ( 10 ) page: 1426-1430   2012.5

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  21. Discharge of solubilized and Dectin-1-reactive β-glucan from macrophage cells phagocytizing insoluble β-glucan particles: involvement of reactive oxygen species (ROS)-driven degradation. Reviewed

    Hino, S., Kito, A., Yokoshima, R., Sugino, R., Oshima, K., Morita, T., Okajima, O., Nadano, D., Uchida, K. and Matsuda, T.

    Biochem. Biophys. Res. Commun.   Vol. 421 ( 2 ) page: 329-334   2012.5

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  22. O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1. Reviewed

    Sakaidani, Y., Ichiyanagi, N., Saito, C., Nomura, T., Ito, M., Nishio, Y., Nadano, D., Matsuda, T., Furukawa, K., and Okajima, T.

    Biochem. Biophys. Res. Commun.   Vol. 419 ( 1 ) page: 14-19   2012.3

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  23. O-Linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions. Reviewed

    Sakaidani, Y., Nomura, T., Matsuura, A., Ito, M., Suzuki, E., Murakami, K., Nadano, D., Matsuda, T., Furukawa, K., and Okajima, T.

    Nat. Commun.   Vol. 2   page: 583   2011.12

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    DOI: 10.1038/ncomms1591

  24. Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin. Reviewed

    Moriya, H., Uchida, K., Okajima, T., Matsuda, T., and Nadano, D.

    Arch. Biochem. Biophys.   Vol. 508 ( 1 ) page: 87-92   2011.4

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  25. Transplantation of a mammary stromal cell line into a mammary fat pad: development of the site-specific in vivo analysis system for mammary stromal cells. Reviewed

    Nakatani, H., Aoki, N., Nadano, D., and Matsuda T.

    Biosci. Biotechnol. Biochem.   Vol. 75 ( 3 ) page: 550-555   2011.3

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  26. IgG2 dominancy and carbohydrate recognition specificity of C3H/He mouse antibodies directed to cross-reactive carbohydrate determinants (CCDs) bearing ß-(1,2)-xylose and α-(1,3)-fucose. Reviewed

    Hino, S., Umeda, F., Inumaru, S., Aoki, N. Sato, C., Okajima, T., Nadano, D., and Matsuda, T.

    Immunol Lett.   Vol. 133 ( 1 ) page: 28-34   2010.9

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  27. Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA-binding protein in early involution of the mouse mammary gland. Reviewed

    Taga, Y., Miyoshi, M., Okajima, T., Matsuda, T., and Nadano, D.

    Cell Biochem. Function   Vol. 28 ( 4 ) page: 321-328   2010.6

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  28. Proteomic analysis of rodent ribosomes revealed heterogeneity including ribosomal proteins L10-like, L22-like 1, and L39-like. Reviewed

    Sugihara, Y., Honda, H., Iida, T., Morinaga, T., Hino, S., Okajima, T., Matsuda, T., and Nadano, D.

    J. Proteome Res.   Vol. 9 ( 3 ) page: 1351-1366   2010.3

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  29. Binding of Norovirus virus-like particles (VLPs) to human intestinal Caco-2 cells and suppressive effect of pasteurized bovine colostrum on the VLPs-binding. Reviewed

    Murakami, K., Aoki, N., Nakatani, H., Asano, Y., Miura, Y., Okajima, T., Nadano, D., Inagaki, M., Kanamaru, Y., and Matsuda, T.

    Biosci. Biotech. Biochem.   Vol. 74 ( 3 ) page: 541-547   2010.3

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  30. Establishment of a mammary stromal fibroblastic cell line for in vitro studies in mice of mammary adipocyte differentiation. Reviewed

    Nakatani, H., Aoki, N., Okajima, T., Nadano, D., Flint, D., and Matsuda T.

    Biol. Reprod.   Vol. 82 ( 1 ) page: 44-53   2010.1

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  31. Serum and monoclonal IgE antibodies from NC/Nga mice with severe atopic-like dermatitis recognize an autoantigen, histone H3. Reviewed

    Matsubara, T., Aoki, N., Hino, S., Okajima, T., Nadano, D., and Matsuda, T.

    Clin. Exp. Allergy   Vol. 39 ( 4 ) page: 579-590   2009.4

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  32. Periodate-resistant carbohydrate epitopes recognized by IgG and IgE antibodies from some of the immunized mice and patients with allergy. Reviewed

    Hino, S., Matsubara, T., Urisu, A., Aoki, N., Sato, C., Okajima, T., Nadano, D., and Matsuda, T.

    Biochem. Biophys. Res. Commun.   Vol. 380 ( 3 ) page: 632-637   2009.3

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  33. Development and evaluation of transgenic rice seeds accumulating a type II-collagen tolerogenic peptide. Reviewed

    Hashizume, F., Hino, S., Kakehashi, M., Okajima, O., Nadano, D., Aoki, N., and Matsuda, T.

    Transgenic Res.   Vol. 17 ( 6 ) page: 1117-1129   2008.12

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  34. O-linked GlcNAc is present on the extracellular domain of notch receptors. Reviewed

    Matsuura, A., Ito, M., Sakaidani, Y., Kondo, T., Murakami, K., Furukawa, K, Nadano, D. , Matsuda, T., and Okajima, T.

    J. Biol. Chem.   Vol. 283 ( 51 ) page: 35486-35495   2008.12

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  35. Absorption, migration and kinetics in peripheral blood of orally administered ovalbumin in a mouse model. Reviewed

    Matsubara, T., Aoki, N., Honjoh, T., Mizumachi, K., Kurahashi, J., Okajima, T., Nadano, D., and Matsuda, T.

    Biosci. Biotech. Biochem.   Vol. 72 ( 10 ) page: 2555-2565   2008.10

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  36. Suppressive expression of the glutelin A1-collagen peptide fusion gene in hybrid rice lines with the mutant line, Low Glutelin Content-1 (LGC-1). Reviewed

    Hashizume, F., Hino, S., Okajima, T., Nadano, D., Aoki, N., and Matsuda, T.

    Plant Biotechnol.   Vol. 25 ( 5 ) page: 465-471   2008.9

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  37. Enhancement of human sperm motility by trophinin-binding peptide. Reviewed

    Hatakeyama, S., Sugihara, K., Lee, S. H., Nadano, D., Nakayama, J. Ohyama, C., and Fukuda, M. N.

    J. Urol.   Vol. 180 ( 2 ) page: 767-771   2008.8

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  38. The role of bystin in embryo implantation and in ribosomal biogenesis. Invited Reviewed

    Fukuda, M. N., Miyoshi, M., and Nadano, D.

    Cell. Mol. Life Sci.   Vol. 65 ( 1 ) page: 92-99   2008.1

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  39. Association of chicken zona pellucida glycoprotein (ZP) B1 with ZPC induces formation of ZPB1-ZPC fibrous aggregates containing disulfide-bridged ZPB1 dimer. Reviewed

    Okumura, H., Okajima, T., Nadano, D., and Matsuda, T.

      Vol. 364 ( 3 ) page: 682-688   2007.12

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  40. The role of trophinin, an adhesion molecule unique to human trophoblasts, in progression of colorectal cancer. Reviewed

    Harada, O., Suga, T., Suzuki, T., Nakamoto, K., Kobayashi, M., Nomiyama, T., Nadano, D. , Ohyama, C., Fukuda, M. N., and Nakayama, J.

    Int. J. Cancer   Vol. 121 ( 5 ) page: 1072-1078   2007.9

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  41. Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis. Reviewed

    Miyoshi, M., Okajima, T., Matsuda, T., Fukuda, M. N., and Nadano, D.

    Biochem. J.   Vol. 404 ( 3 ) page: 373-381   2007.6

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  42. Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation. Reviewed

    Sugihara, K., Sugiyama, D., Byrne, J., Wolf, D. P., Lowitz, K. P., Kobayashi, Y., Kabir-Salmani, M., Nadano, D., Aoki, D., Nozawa, S., Nakayama, J., Mustelin, T., Ruoslahti, E., Yamaguchi, N., and Fukuda, M. N.

    Proc. Nat. Acad. Sci. USA   Vol. 104 ( 10 ) page: 3799-3804   2007.3

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  43. Heterocomplex formation and cell-surface accumulation of hen's serum zona pellucida B1 (ZPB1)with ZPC expressed by a mammalian cell line (COS-7): a possible initiating step of egg-envelope matrix construction. Reviewed

    Okumura, H., Aoki, N., Sato, C., Nadano, D., and Matsuda, T.

    Biol. Reprod.   Vol. 76 ( 1 ) page: 9-18   2007.1

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  44. The Bysl gene product, bystin, is essential for survival of mouse embryos. Reviewed

    Aoki, R,, Suzuki, N., Paria, B. C., Sugihara, K., Akama, T. O., Raab, G., Miyoshi, M., Nadano, D., and Fukuda, M. N.

    FEBS Lett.   Vol. 580 ( 26 ) page: 6062-6068   2006.11

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  45. Antioxidant and antibacterial genes are upregulated in early involution of the mouse mammary gland: sharp increase of ceruloplasmin and lactoferrin in accumulating breast milk. Reviewed

    Nakamura, M., Tomita, A., Nakatani, H, Matsuda, T., and Nadano, D.

    DNA Cell Biol.   Vol. 25 ( 9 ) page: 491-500   2006.9

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  46. Weaning-induced expression of a milk-fat globule protein, MFG-E8, in mouse mammary glands as demonstrated by the analyses of its mRNA, protein and phosphatidylserine-binding activity. Reviewed

    Nakatani, H., Aoki, N., Nakagawa, Y., Jin-no, S., Aoyama, K., Oshima, K., Ohira, S., Sato, C., Nadano D., and Matsuda, T.

    Biochem. J.   Vol. 395 ( 1 ) page: 21-30   2006.4

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  47. Apical cell adhesion molecule, trophinin, localizes to cell surface, cytoplasm and nuclear envelope. Reviewed

    Aoyama, J., Nakayama, Sugiyama, D., Nadano, D., Fukuda, M. N., and Yamaguchi, N.

    FEBS Lett.   Vol. 579 ( 28 ) page: 6326-6332   2005.11

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  48. A newly identified ZP glycoprotein, ZPD, and dimeric ZP1 of chicken egg-envelope are involved in sperm activation on sperm-egg interaction. Reviewed

    Okumura, H., Kohno, Y., Iwata, Y., Mori, H., Aoki, N., Sato, C., Kitajima, K., Nadano, D., and Matsuda, T.

    Biochem. J.   Vol. 384 ( 1 ) page: 191-199   2004.11

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  49. Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnancies: possible role of human chorionic gonadotrophin on ectopic pregnancy. Reviewed

    Nakayama, J., Aoki, D., Suga, T., Akama, T. O., Ishizone, S., Yamaguchi, H., Imakawa, K., Nadano, D., Fazleabas, A. T., Katsuyama, T., Nozawa, S., and Fukuda, M. N.

    Am. J. Pathol.   Vol. 163 ( 6 ) page: 2211-2219   2003.12

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  50. Differential expression of ribosomal proteins in human normal and neoplastic colorectum. Reviewed

    Kasai, H., Nadano, D., Hidaka, E., Higuchi, K., Kawakubo, M., Sato, T., and Nakayama, J.

    J. Histochem. Cytochem.   Vol. 51 ( 5 ) page: 567-574   2003.5

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  51. A human gene encoding a protein homologous to ribosomal protein L39 is normally expressed in the testis and derepressed in multiple cancer cells. Reviewed

    Nadano, D., Notsu, T., Matsuda, T., and Sato, T.

    Biochim. Biophys. Acta   Vol. 1577 ( 3 ) page: 430-436   2002.9

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  52. Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton. Reviewed

    Nadano, D., Nakayama, J., Matsuzawa, S., Sato, T., Matsuda, T., and Fukuda, M. N.

    Biochem. J.   Vol. 364 ( 3 ) page: 669-677   2002.6

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  53. Structural change of ribosomes during apoptosis: degradation and externalization of ribosomal proteins in doxorubicin-treated Jurkat cells. Reviewed

    Nishida, J., Shiratsuchi, A., Nadano, D., Sato, T., and Nakanishi, Y.

    J. Biochem.   Vol. 131 ( 3 ) page: 485-493   2002.3

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  54. Significant differences between mouse and human trophinins are revealed by their expression patterns and targeted disruption of mouse trophinin gene. Reviewed

    Nadano, D., Sugihara, K., Paria, B. C., Saburi, S., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Nakayama, J., and Fukuda, M. N.

    Biol. Reprod.   Vol. 66 ( 2 ) page: 313-321   2002.2

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  55. Electrophoretic characterization of ribosomal subunits and proteins in apoptosis. Specific down-regulation of S11 in human breast carcinoma treated with staurosporine. Reviewed

    Nadano, D., Aoki, C., Yoshinaka, T., Irie, S., and Sato, T.

    Biochemistry   Vol. 40 ( 50 ) page: 15184-15193   2001.12

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  56. The trophinin gene encodes a novel group of MAGE proteins, Magphinins, and regulates cell proliferation during gametogenesis in the mouse. Reviewed

    Saburi, S., Nadano, D., Akama, T. O., Hirama, K., Yamanouchi, K., Naito, K., Tojo, H., Tachi, C., and Fukuda, M. N.

    J. Biol. Chem.   Vol. 276 ( 52 ) page: 49378-49389   2001.12

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  57. 14-3-3 is involved in p75 neurotrophin receptor (p75NTR)-mediated signal transduction. Reviewed

    Kimura, M. T., Irie S., Shoji-Hoshino S., Mukai J., Nadano D., Oshimura M., and Sato, T.

    J. Biol. Chem.   Vol. 276 ( 20 ) page: 17291-17300   2001.5

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  58. Trophinin expression in the mouse uterus coincides with implantation and is hormonally regulated but not induced by implanting blastocysts. Reviewed

    "Suzuki, N., Nadano, D., Paria, B. C., Kupriyanov, S., Sugihara, K., and Fukuda, M. N."

    Endocrinology   Vol. 141 ( 11 ) page: 4247-4254   2000.11

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  59. Preparation and Characterization of Antibodies against Human Ribosomal Proteins. Heterogeneous Expression of S11 and S30 in a Panel of Human Cancer Cell Lines. Reviewed

    Nadano, D., Ishihara, G., Aoki, C., Yoshinaka, T., Irie, S., and Sato, T.

    Jpn. J. Cancer Res.   Vol. 91   page: 802-810   2000.8

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  60. NADE, p75NTR-associated cell death executor, is involved in the common neurotrophin receptor p75NTR-mediated signal transduction. Reviewed

    Mukai, J., Hachiya, T., Hoshino, S., Kimura, M., Nadano, D., Suvanto, P., Hanaoka, T., Li, Y., Irie, S., and Sato, T.

    J. Biol. Chem.   Vol. 275 ( 23 ) page: 17566-17570   2000.6

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  61. Caspase-3-dependent and -independent degradation of 28 S ribosomal RNA may be involved in the inhibition of protein synthesis during apoptosis initiated by death receptor engagement. Reviewed

    Nadano, D., and Sato, T.

    J. Biol. Chem.   Vol. 275 ( 18 ) page: 13967-13973   2000.5

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  62. Anthropological applications of genetic polymorphisms detected in human urine: a review of Japanses studies Invited

    Yasuda, T., Nadano, D., Takeshita, H., Iida, R., and Kishi, K.

    Rivista di Antropologia   Vol. 75   page: 145-155   1997

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  63. Alpha-2-HS-glycoprotein (AHSG) polymorphism in semen andsaliva. Reviewed

    Yasuda, T., Takeshita, H., Tsubota, E., Sawazaki, K., Iida, R., Nadano,D., and Kishi, K.

    Electrophoresis   Vol. 17 ( 4 ) page: 793-796   1996

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  64. A new individualization marker of sweat: deoxyribonuclease I (DNase I) polymorphism. Reviewed

    Yasuda, T., Takeshita, H., Sawazaki, K., Nadano, D., Iida, R., Miyahara, S., and Kishi, K.

    J. Forensic Sci.   Vol. 41 ( 5 ) page: 862-864   1996

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  65. Purification of mammalian ribonuclease using immobilized human ribonuclease inhibitor. Reviewed

    Nadano, D., Yasuda, T., Takeshita, H., Sawazaki, K.. and Kishi, K.

    Protein Expr. Purif.   Vol. 7 ( 2 ) page: 167-172   1996

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  66. pH gradient electrophoresis of basic ribonucleases in sealed slabpolyacrylamide gels: detection and inhibition of enzyme activity in thegel. Reviewed

    Nadano, D., Yasuda, T., Sawazaki, K., Takeshita, H., and Kishi, K.

    Electrophoresis   Vol. 17 ( 1 ) page: 104-109   1996

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  67. Ribonucleaseinhibitors in human blood: comparative studies on the inhibitors detectedin erythrocytes, platelets, mononuclear leukocytes and granulocytes. Reviewed

    Nadano, D., Yasuda, T., Takeshita, H., and Kishi, K.

    Int. J. Biochem. Cell Biol.   Vol. 27 ( 9 ) page: 971-979   1995

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  68. Molecular analysis of the third allele of human deoxyribonuclease I polymorphism. Reviewed

    Yasuda, T., Nadano, D., Takeshita, H., Tenjo, E., and Kishi, K.

    Ann. Hum. Genet.   Vol. 59 ( 2 ) page: 139-147   1995

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  69. Deoxyribonuclease I from rat urine: affinity purification, characterization, and immunochemical studies. Reviewed

    Takeshita, H., Yasuda, T., Nadano, D., Iida, R., and Kishi, K.

    J. Biochem.   Vol. 118 ( 5 ) page: 932-938   1995

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  70. Chromosomal assignment of the human deoxyribonuclease Igene, DNASE1 (DNL1), to band 16p13.3 using the polymerase chain reaction. Reviewed

    Yasuda, T., Nadano, D., Iida, R., Takeshita, H., Lane, S.A., Callen, D.F., and Kishi, K.

    Cytogen. Cell Genet.   Vol. 70 ( 3-4 ) page: 221-223   1995

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  71. Activity staining of mammalian ribonuclease inhibitors after electrophoresis in sealedvertical slab polyacrylamide gels. Reviewed

    Nadano, D., Yasuda, T., Takeshita, H., and Kishi, K.

    Anal. Biochem.   Vol. 227 ( 1 ) page: 210-215   1995

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  72. Genotyping of human deoxyribonuclease Ipolymorphism by the polymerase chain reaction. Reviewed

    Yasuda, T., Nadano, D., Tenjo, E., Takeshita, H., Sawazaki, K., Nakanaga, M., and Kishi K.

    Electrophoresis   Vol. 16 ( 10 ) page: 1889-1893   1995

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  73. Correlation of alpha-1-antitrypsin (PI)polymorphism between blood and semen. Reviewed

    Sawazaki, K., Takeshita, H., Tenjo, E., Nadano, D., Yasuda, T., Iida, R., and Kishi, K.

    Jpn. J. Legal Med.   Vol. 49 ( 2 ) page: 65-69   1995

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  74. The molecular basis for genetic polymorphism of humandeoxyribonuclease I: identification of the nucleotide substitution thatgenerates the fourth allele. Reviewed

    Yasuda, T., Nadano, D., Takeshita, H., Tenjo, E., Sawazaki, K., Ootani, M., and Kishi, K.

    FEBS Lett.   Vol. 359 ( 2-3 ) page: 211-214   1995

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  75. Detection of deoxyribonucleases I and II (DNases I and II) activities in reproductive organs of male rabbits. Reviewed

    Takeshita, H., Yasuda, T., Nadano, D., Tenjo, E., Sawazaki, K., Iida, R., and Kishi , K.

    Int. J. Biochem.   Vol. 26 ( 8 ) page: 1025-1031   1994

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  76. Purification and characterization of human brain ribonuclease inhibitor. Reviewed

    Nadano, D., Yasuda, T., Takeshita, H., Uchide, K., and Kishi, K.

    Arch. Biochem. Biophys   Vol. 312 ( 2 ) page: 421-428   1994

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  77. Genetically polymorphic alpha-L-fucosidase(FUCA1) isozymes detected in blood plasma. Reviewed

    Takeshita, H., Yasuda, T., Nadano, D., Iida, R., Nakanaga, M., Tenjo, E., Sawazaki, K. and Kishi K.

    Hum. Genet.   Vol. 94 ( 3 ) page: 224-230   1994

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  78. Use of antibodies against synthetic peptides for analysis of molecular multiplicity: humandeoxyribonuclease I. Reviewed

    Yasuda, T., Nadano, D., Takeshita, H., and Kishi, K.

    Electrophoresis   Vol. 15 ( 2 ) page: 260-264   1994

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  79. Salivary deoxyribonuclease I polymorphism separated by polyacrylamide gel-isoelectric focusing and detected by the dried agarose film overlay method. Reviewed

    Tenjo, E., Sawazaki, K., Yasuda, T., Nadano, D., Takeshita, H., Iida, R., and Kishi, K.

    Electrophoresis   Vol. 14 ( 10 )   1993

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  80. Postmortem concentrations of thiopental in tissues: a sudden death case. Reviewed

    Yasuda, T., Yamaba, T., Sawazaki, K., Masuyama, F., Nadano, D., Takeshita, H., and Kishi, K.

    Int. J. Legal Med.   Vol. 105 ( 4 ) page: 239-241   1993

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  81. Measurement of deoxyribonuclease I activity in human tissues and body fluids by a single radial enzyme-diffusion method. Reviewed

    Nadano, D., Yasuda, T., and Kishi, K.

    Clin. Chem.   Vol. 39 ( 3 ) page: 448-452   1993

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  82. Activity measurement and multiplicity detection of human secretory-type ribonuclease based on polycytidylic acid/ethidium bromide fluorescence. Reviewed

    Nadano, D., Yasuda, T., Sawazaki, K., Takeshita, H., and Kishi , K.

    Anal. Biochem.   Vol. 212 ( 1 ) page: 111-116   1993

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  83. Survey of the association of deoxyribonuclease I polymorphism with disease. Reviewed

    Yasuda, T., Nadano, D., Tenjo, E., Takeshita, H., Nakanaga, M., and Kishi, K.

    Hum. Hered.   Vol. 43 ( 4 ) page: 205-208   1993

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  84. Deoxyribonuclease I (DNase I) typing from semen stains: low enzyme activity in vaginal fluids does not interfere with seminal DNase I typing from mixture stains. Reviewed

    Sawazaki, K., Yasuda, T., Nadano, D., Iida, R., Takeshita, H., Uchide, K., and Kishi, K.

    J. Forensic Sci.   Vol. 38 ( 5 ) page: 1051-1062   1993

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  85. Human seminal deoxyribonuclease I (DNase I): purification, enzymological and immunological characterization and origin. Reviewed

    Yasuda, T., Sawazaki, K., Nadano, D., Takeshita, H., Nakanaga, M., and Kishi, K.

    Clin. Chim. Acta   Vol. 218 ( 1 ) page: 5-16   1993

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  86. Kappa marker typing with high-performance liquid chromatography: identification of kappa marker specific tryptic peptide from the kappa light chain ofimmunoglobulin G. Reviewed

    Iida, R., Yasuda, T., Nadano, D., Takeshita, H., and Kishi, K.

    J. Chromatogr.   Vol. 622 ( 1 ) page: 9-12   1993

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  87. Two distinct secretory ribonucleases from human cerebrum: purification, characterization and relationships to other ribonucleases. Reviewed

    Yasuda, T., Nadano, D., Takeshita, H., and Kishi, K.

    Biochem. J.   Vol. 296 ( 3 ) page: 617-625   1993

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  88. Specific identification of human ribonucleases by antibodies produced against two synthetic peptides corresponding to the N- and C-terminal amino-acid sequences of human urinary secretory-type ribonuclease. Reviewed

    Yasuda, T., Nadano, D., Tanaka, Y., and Kishi, K.

    Biochim. Biophys. Acta   Vol. 1121 ( 3 ) page: 331-334   1992

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  89. The zymogram method for detection of ribonucleases after isoelectric focusing:analysis of multiple forms of human, bovine, and microbial enzymes. Reviewed

    Yasuda, T., Nadano, D., Tenjo, E., Takeshita, H., and Kishi, K.

    Anal. Biochem.   Vol. 206 ( 1 ) page: 172-177   1992

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  90. Transferrin (TF) typing from semen stains using isoelectric focusing andimmunoblotting: correlation of TF types among blood, semen, urine, andvaginal secretion. Reviewed

    Sawazaki, K., Yasuda, T., Nadano, D., Iida, R., and Kishi, K.

    J. Forensic Sci.   Vol. 37 ( 6 ) page: 1514-1524   1992

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  91. Human urine deoxyribonuclease II (DNase II) isoenzymes: a novel immunoaffinity purification, biochemical multiplicity, genetic heterogeneity and broad distribution among tissues and body fluids. Reviewed

    Yasuda, T., Nadano, D., Awazu, S., and Kishi, K.

    Biochim. Biophys. Acta   Vol. 1119 ( 2 ) page: 185-193   1992

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  92. A new individualization marker of semen: deoxyribonuclease I (DNase I) polymorphism. Reviewed

    Sawazaki, K., Yasuda, T., Nadano, D., Tenjo, E., Iida, R., Takeshita, H., and Kishi K.

    Forensic Sci. Int.   Vol. 57 ( 1 ) page: 39-44   1992

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  93. Discovery of a genetic polymorphism of human plasma protein C inhibitor(PCI): genetic survey utilizing isoelectric focusing followed byimmunoblotting, immunological and biochemical characterization. Reviewed

    Yasuda, T., Nadano, D., Iida, R., Tanaka, Y., Nakanaga, M., and Kishi, K.

    Hum. Genet.   Vol. 89 ( 3 ) page: 265-269   1992

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  94. Genetic polymorphism of human deoxyribonuclease II (DNase II): low activity levels in urine and leukocytes are due to an autosomal recessive allele. Reviewed

    Yasuda, T., Nadano, D., Sawazaki, K., and Kishi, K.

    Ann. Hum. Genet.   Vol. 56 ( 1 ) page: 1-10   1992

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  95. Transferrin polymorphisms in Japanese populations: north-southcline in the distribution of the TF*C2 allele. Reviewed

    Nakanaga, M., Yasuda, T., Tenjo, E., Nadano, D., Fujiki, N., and Kishi, K.

    Hum. Biol.   Vol. 63 ( 2 ) page: 187-195   1991

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  96. Purification and characterization of genetically polymorphic deoxyribonuclease I from human kidney. Reviewed

    Nadano, D., Yasuda, T., and Kishi K.

    J. Biochem.   Vol. 110 ( 3 ) page: 321-323   1991

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  97. Genetic polymorphism of human glutamateoxaloacetate transaminase (GOT1) detected using isoelectric focusing and asensitive and positive staining method. Reviewed

    Nakanaga, M., Nadano, D., Yasuda, T., Tenjo, E., Sawazaki, K., Iida, R., Fujiki, N., and Kishi, K.

    Int. J. Legal Med.   Vol. 104 ( 3 ) page: 121-122   1991

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  98. Noveldetection method for human protein C inhibitor (PCI) using immunoblottingwith antibodies specific to synthetic peptides corresponding to theN-terminal and C-terminal amino acid sequences of human PCI. Reviewed

    Yasuda, T., Nadano, D., Tanaka, Y., Sawazaki, K., and Kishi, K.

    Biochem. Int.   Vol. 25 ( 3 ) page: 553-560   1991

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  99. Transferrin subtyping of bloodstains and semen using isoelectricfocusing and immunoblotting. Reviewed

    Yamaba, T., Sawazaki, K., Yasuda, T., Nadano, D., Iida, R., and Kishi, K.

    Forensic Sci. Int.   Vol. 50 ( 2 ) page: 187-194   1991

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  100. Isolation of H and Leb active human salivary mucins and structures of their sugar chains with the H and Ley (Y)determinants. Reviewed

    Nadano, D., and Mukoyama, H.

    Jpn. J. Legal Med.   Vol. 44 ( 4 ) page: 259-266   1990

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  101. Practical utility of an antibody specific to a synthetic peptidecorresponding to the N-terminal amino acid sequence of human urine DNase Ifor genetic analysis of human DNase I isozymes. Reviewed

    Yasuda, T., Nadano, D., Tanaka, Y., Sato, W., Nakanaga, M., and Kishi, K.

    Biochem. Int.   Vol. 22 ( 4 ) page: 699-705   1990

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  102. Intensification ofperoxidase-diaminobenzidine staining using gold-sulfide-silver: a rapid andhighly sensitive method for visualization in immunoblotting. Reviewed

    Iida, R., Yasuda, T,. Nadano, D., and Kishi, K.

    Electrophoresis   Vol. 11 ( 10 ) page: 852-855   1990

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  103. Isolation and structure of a novel deaminated neuraminic acid containing oligosaccharide chain present in rainbow trout egg polysialoglycoprotein. Reviewed

    Iwasaki, M., Inoue, S., Nadano, D., and Inoue, Y.

    Biochemistry   Vol. 26 ( 5 ) page: 1452-1457   1987

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  104. A naturally occurring deaminated neuraminic acid,3-deoxy-D-glycero-D-galactononulosonic acid (KDN). Its unique occurrence at the nonreducing ends of oligosialyl chains in polysialoglycoprotein of rainbow trout eggs. Reviewed

    Nadano, D., Iwasaki, M., Endo, S., Kitajima, K., Inoue, S., and Inoue, Y.

    J. Biol. Chem.   Vol. 261 ( 25 ) page: 11550-11557   1986

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KAKENHI (Grants-in-Aid for Scientific Research) 5

  1. ふぞろいな翻訳系:哺乳類リボソーム不均一性因子による新規翻訳制御機構の統括的理解

    Grant number:21K05379  2021.4 - 2025.3

    科学研究費補助金  基盤研究(C)

    灘野 大太

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    真核細胞におけるmRNAの転写後輸送、リボソーム生合成およびリボソームでの翻訳は往々にして別々に解析されてきた。ただ細胞内で必要なmRNAが転写されたとしても、mRNAを核外へさらにリボソームに輸送することならびに必要な量のリボソームを作り細胞質へ輸送することの両者が整う必要があり、加えて翻訳においてリボソームが効率よく機能しなければ、細胞にとって非効率的なばかりでなく、不具合の程度によっては生存能力に深刻な影響を与えうる。この相互のバランスの解明を本研究において進める。

  2. Studies of novel mechanisms regulating cell growth by functional cooperation between nuclear ribosome biogenesis and cytoplasmic translation

    Grant number:17K07751  2017.4 - 2020.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(C)

    Nadano Daita

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    To study the mechanisms regulating cell growth by functional cooperation between nuclear ribosome biogenesis and cytoplasmic translation, we comprehensively analyzed the protein constituents of mammalian ribosomes. Serbp1, known as an mRNA-binding protein, was identified to be associated with the ribosomal small subunit in an mRNA-independent manner. Microscopic and biochemical analyses of Serbp1 indicated that this protein was mainly located in the nucleolus, a place where ribosome biogenesis occurs, within the nucleus and included in cytoplasmic polysomes including translating ribosomes. In addition, we identified and analyzed the novel proteins potentially involved in the mechanisms.

  3. 哺乳類精巣リボソームの構造不均一性がもたらす新規翻訳制御メカニズムの包括的解明

    2013.4 - 2016.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  4. 細胞自己複製および翻訳を共に促進する新規特性タンパク質の筋肉老化予防への応用

    2009.4 - 2012.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  5. 退縮初期の乳および乳腺からの新規生体防御因子のプロテオミクス的同定と機能解析

    2006.4 - 2008.3

    科学研究費補助金  基盤研究(C)(一般)

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    Authorship:Principal investigator 

    科研費

 

Teaching Experience (On-campus) 15

  1. Biochemistry IV

    2021

  2. Advanced Molecular Cell Biology 2

    2021

  3. Molecular Cell Biology 1

    2021

  4. Biochemistry 1

    2021

  5. Molecular Cell Biology 1

    2020

  6. Biochemistry 1

    2020

  7. 修士論文研究4

    2020

  8. 修士論文研究3

    2020

  9. 修士論文研究2

    2020

  10. 修士論文研究1

    2020

  11. 生命農学演習4

    2020

  12. 生命農学演習3

    2020

  13. 生命農学演習2

    2020

  14. 生命農学演習1

    2020

  15. 分子細胞生物学特論2

    2020

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