Updated on 2024/03/29

写真a

 
TAKI Tomoki
 
Organization
Nagoya University Hospital Dermatology Assistant Professor
Graduate School
Graduate School of Medicine
Title
Assistant Professor

Degree 2

  1. PhD ( 2019.3   Nagoya University ) 

  2. MD ( 2012.3   Nagoya University ) 

Research Interests 4

  1. 遺伝性皮膚疾患

  2. 角化症

  3. 自己炎症性角化症

  4. 皮膚科学

Research Areas 2

  1. Life Science / Dermatology

  2. Life Science / Dermatology

Research History 2

  1. Nagoya University Hospital   Dermatology   Assistant Professor

    2021.4

  2. Nagoya University Hospital   Dermatology   assistant professor

    2020.7 - 2021.3

Education 1

  1. 名古屋大学大学院   医学系研究科   皮膚科科学分野 博士課程

    2015.4 - 2019.3

Professional Memberships 3

  1. THE JAPANESE SOCIETY FOR INVESTIGATIVE DERMATOLOGY

  2. THE JAPANESE DERMATOLOGICAL ASSOCIATION

  3. JAPANESE SOCIETY OF ALLERGOLOGY

Committee Memberships 1

  1. 公益社団法人 日本皮膚科学会   キャリア支援委員会  

    2023.1   

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    Committee type:Academic society

Awards 2

  1. "Graduate School of Medicine Medical Encouragement Award" Grand Prize 2020

    2021.2   Nagoya University Graduate School of Medicine  

    Tomoki Taki

  2. 平成30年度名古屋大学医師会研究奨励賞

    2018.11   名古屋大学医師会  

    滝 奉樹

 

Papers 32

  1. 特集 psoriatic disease~全身疾患へのアプローチ~ 臨床例 SAPHO症候群に併発した汎発性膿疱性乾癬

    江畑 葵, 小泉 遼, 滝 奉樹, 山下 雄太, 秋山 真志

    皮膚病診療   Vol. 45 ( 10 ) page: 916 - 920   2023.10

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    Publisher:協和企画  

    DOI: 10.24733/pd.0000003525

    CiNii Research

  2. Low plasma fibrinogen levels are associated with poor prognosis in cutaneous angiosarcoma of the head and neck

    Taki, T; Mori, S; Murakami, Y; Urata, T; Okumura, M; Akanabe, H; Ebata, A; Imai, S; Yokota, K; Akiyama, M

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   Vol. 142 ( 12 ) page: S265 - S265   2022.12

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  3. Successful dupilumab treatment for ichthyotic and atopic features of Netherton syndrome

    Murase, C; Takeichi, T; Taki, T; Yoshikawa, T; Suzuki, A; Ogi, T; Suga, Y; Akiyama, M

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   Vol. 141 ( 10 ) page: S177 - S177   2021.10

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    Language:Japanese  

    Web of Science

  4. Neutrophil/lymphocyte ratio as a predictor of lymph node metastasis in extramammary Paget disease: A retrospective study

    Ebata, A; Taki, T; Mori, S; Murakami, Y; Okumura, M; Akanabe, H; Imai, S; Yokota, K; Akiyama, M

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   Vol. 141 ( 10 ) page: S197 - S197   2021.10

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    Language:Japanese  

    Web of Science

  5. Roles of aberrant hemichannel activities due to mutant connexin26 in the pathogenesis of KID syndrome

    Taki, T; Takeichi, T; Sugiura, K; Akiyama, M

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   Vol. 139 ( 9 ) page: S248 - S248   2019.9

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    Language:Japanese  

    DOI: 10.1016/j.jid.2019.07.196

    Web of Science

  6. Correlation of serum allergen-specific IgE with total serum IgE and IgE specific to other allergens in Atopic dermatitis patients. International journal

    Norika Akashi, Mariko Ogawa-Momohara, Tomoki Taki, Ryo Fukaura, Keiko Wakahara, Satoshi Kamiya, Yuta Yamashita, Haruka Koizumi, Takuya Takeichi, Yoshinao Muro, Masashi Akiyama

    Journal of the European Academy of Dermatology and Venereology : JEADV     2024.2

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  7. デュピルマブの長期使用によるアトピー性皮膚炎におけるアレルゲン特異的IgG4の増加

    桃原 真理子, 室 慶直, 村瀬 千晶, 滝 奉樹, 棚橋 華奈, 山下 雄太, 小泉 遼, 深浦 遼, 武市 拓也, 秋山 真志

    日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集   Vol. 53回   page: 203 - 203   2023.12

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    Language:Japanese   Publisher:(一社)日本皮膚免疫アレルギー学会  

  8. SREBF1変異を有する先天性魚鱗癬IFAP症候群患者の角質層脂質組成解析

    水野 佑香, 城島 啓佑, 滝 奉樹, 武市 拓也, 秋山 真志, 木原 章雄

    日本生化学会大会プログラム・講演要旨集   Vol. 96回   page: [1T04a - 092)]   2023.10

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    Language:Japanese   Publisher:(公社)日本生化学会  

  9. Allergen-specific IgG4 increase in atopic dermatitis with long-term dupilumab use. International journal

    Mariko Ogawa-Momohara, Yoshinao Muro, Chiaki Murase, Tomoki Taki, Kana Tanahashi, Yuta Yamashita, Haruka Koizumi, Ryo Fukaura, Takuya Takeichi, Masashi Akiyama

    The British journal of dermatology   Vol. 189 ( 4 ) page: 472 - 474   2023.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/bjd/ljad207

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  10. Mild generalised pustular psoriasis patient with a heterozygous hypomorphic MPO variant successfully treated with granulocyte and monocyte adsorption apheresis. International journal

    Takuya Takeichi, Takenori Yoshikawa, Muhammad Nasir Iqbal, Muhammad Farooq, Tomoki Taki, Yoshinao Muro, Yutaka Shimomura, Mariko Seishima, Masashi Akiyama

    Experimental dermatology   Vol. 32 ( 9 ) page: 1557 - 1562   2023.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    Pathogenic variants in MPO, which encodes the myeloperoxidase, were reported as causative genetic defects in several cases of generalised pustular psoriasis (GPP) in addition to patients with myeloperoxidase deficiency in 2020. However, which clinical subtypes of GPP patients have pathogenic variants in MPO remains largely undetermined, and elucidating this is clinically important. The present report outlines a mild case of GPP with a rare missense heterozygous variant, c.1810C>T p.(Arg604Cys), in MPO. Our structural analysis and functional assays to measure myeloperoxidase activity suggest that the present MPO substitution is a hypomorphic variant in MPO. Thus, the mild phenotype of the present GPP patient might be associated with an incomplete hypomorphic loss-of-function variant in MPO. Additionally, the severe intractable edematous pustules and erythema improved dramatically after five rounds of granulocyte and monocyte adsorption apheresis (GMA) therapy. This is the first report of GMA treatment for GPP associated with a pathogenic variant in MPO, as far as we know. Our findings suggest that GMA might be a useful and powerful tool for controlling GPP in patients with myeloperoxidase deficiency.

    DOI: 10.1111/exd.14846

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  11. Conradi-Huenermann-Happle症候群の1例

    鈴木 謙仁, 中澤 慎介, 滝 奉樹, 武市 拓也, 船井 尚子, 谷口 章雄, 藤山 俊晴, 伊藤 泰介, 秋山 真志, 本田 哲也

    日本皮膚科学会雑誌   Vol. 133 ( 5 ) page: 1391 - 1391   2023.5

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    Language:Japanese   Publisher:(公社)日本皮膚科学会  

  12. Conradi-Huenermann-Happle症候群の1例

    鈴木 謙仁, 中澤 慎介, 滝 奉樹, 武市 拓也, 船井 尚子, 谷口 章雄, 藤山 俊晴, 伊藤 泰介, 秋山 真志, 本田 哲也

    日本皮膚科学会雑誌   Vol. 133 ( 5 ) page: 1391 - 1391   2023.5

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    Language:Japanese   Publisher:(公社)日本皮膚科学会  

  13. 魚鱗癬の病態における表皮脂質異常・バリア障害と炎症との相互作用の解明

    秋山 真志, 武市 拓也, 棚橋 華奈, 滝 奉樹

    日本皮膚科学会雑誌   Vol. 133 ( 5 ) page: 1428 - 1428   2023.5

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    Language:Japanese   Publisher:(公社)日本皮膚科学会  

  14. 魚鱗癬の病態における表皮脂質異常・バリア障害と炎症との相互作用の解明

    秋山 真志, 武市 拓也, 棚橋 華奈, 滝 奉樹

    日本皮膚科学会雑誌   Vol. 133 ( 5 ) page: 1428 - 1428   2023.5

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    Language:Japanese   Publisher:(公社)日本皮膚科学会  

  15. Whole-exome sequencing reveals a retinitis pigmentosa-causative PRPH2 variant as a secondary finding in a patient with pseudoxanthoma elasticum. Reviewed International journal

    Akira Miyazaki, Takuya Takeichi, Kana Tanahashi, Tomoki Taki, Yosuke Taki, Yoshinao Muro, Masashi Akiyama

    The Journal of dermatology   Vol. 50 ( 2 ) page: e85 - e86   2023.2

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  16. Extremely mild dominant dystrophic epidermolysis bullosa: Genotype information from whole-exome sequencing of salivary gDNA predicts disease severity. Reviewed International journal

    Akira Miyazaki, Takuya Takeichi, So Takeuchi, Tomoki Taki, Yoshinao Muro, Masashi Akiyama

    The Journal of dermatology   Vol. 49 ( 8 ) page: E276 - E277   2022.8

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  17. Darier disease successfully treated with a topical agent containing vitamin A (retinyl palmitate), vitamin E, and urea. Reviewed International journal

    Akira Miyazaki, Tomoki Taki, Takuya Takeichi, Michihiro Kono, Hiroaki Yagi, Masashi Akiyama

    The Journal of dermatology   Vol. 49 ( 8 ) page: 779 - 782   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    Darier disease (DD), also called keratosis follicularis, is an autosomal dominant hereditary keratinization disorder that manifests as keratotic papules with plaques in seborrheic areas. There are no validated curative treatments for DD, with the majority of cases treated symptomatically. We report the efficacy of a topical over-the-counter agent which contains retinyl palmitate, vitamin E, and urea for a patient with DD. A 13-year-old girl had brown papules on her scalp, neck, shoulders, and axillae since entering elementary school. A skin biopsy revealed hyperkeratosis, suprabasal acantholysis, and dyskeratosis manifested as corps ronds and grains in the epidermis. Sanger sequencing found the previously reported heterozygous mutation c.1484C>T in ATP2A2. The application of an over-the-counter topical agent containing retinyl palmitate 2750 μg/g (5000 IU/g), tocopheryl acetate 20 mg/g, urea 200 mg/g, and monoammonium glycyrrhizinate 5 mg/g twice daily for 2 months improved the papules without serious adverse events. Oral or topical aromatic vitamin A analogs (retinoids) are often used to treat DD. However, several adverse events are associated with retinoid treatment, and many patients only undergo their intermittent use or discontinue the treatments. Retinyl palmitate is more stable and has a lower irritative profile than other retinoic acids. When applied topically, however, retinyl palmitate cannot penetrate the skin as well as retinol can. Some reports have noted that vitamin E increases the biological availability of vitamin A and that urea helps mechanical percutaneous drug delivery. Our case suggests that retinyl palmitate has a sufficient therapeutic effect when combined with vitamin E and urea. In conclusion, we propose that topical agents containing retinyl palmitate, vitamin E, and urea might have a satisfactory effect on the skin lesions of DD patients, without the serious risks of adverse events.

    DOI: 10.1111/1346-8138.16395

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  18. 特集 診断に苦慮した症例 臨床例 診断に苦慮したメトトレキサート関連リンパ増殖異常症

    岩田 真衣, 山田 元人, 藤原 慎二, 滝 奉樹, 山下 雄太, 藤城 里香

    皮膚病診療   Vol. 44 ( 1 ) page: 72 - 75   2022.1

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    Publisher:協和企画  

    DOI: 10.24733/pd.0000002813

    CiNii Research

  19. Neutrophil/lymphocyte ratio as a predictor of lymph node metastasis in extramammary Paget disease: A retrospective study. Reviewed International journal

    Aoi Ebata, Tomoki Taki, Shoichiro Mori, Yoshie Murakami, Toru Urata, Mao Okumura, Honami Akanabe, Satoko Imai, Kenji Yokota, Masashi Akiyama

    Journal of the American Academy of Dermatology   Vol. 85 ( 4 ) page: 1023 - 1025   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jaad.2020.12.087

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  20. Low plasma fibrinogen levels are associated with poor prognosis in cutaneous angiosarcoma of the head and neck. Reviewed International journal

    Shoichiro Mori, Tomoki Taki, Yoshie Murakami, Toru Urata, Mao Okumura, Honami Akanabe, Aoi Ebata, Satoko Imai, Kenji Yokota, Masashi Akiyama

    Cancer science   Vol. 112 ( 9 ) page: 3924 - 3927   2021.9

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    Angiosarcoma of the head and neck (ASHN) is one of the most aggressive malignancies of the skin, but the prognostic factors are not well known because of its rarity. Recently, high plasma fibrinogen levels were reported to predict poor prognosis in several malignancies. In the present retrospective study, we suggest that low plasma fibrinogen levels predict poor prognosis for ASHN.

    DOI: 10.1111/cas.15037

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  21. Cutaneous malignant melanoma in an elderly patient with intermediate junctional epidermolysis bullosa. International journal

    Yuta Yamashita, Tomoki Taki, Takuya Takeichi, Mao Okumura, Shoichiro Mori, Yasutoshi Ito, Tomoo Ogi, Motohito Yamada, Masashi Akiyama

    The Journal of dermatology   Vol. 48 ( 8 ) page: E384 - E385   2021.8

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  22. Paradoxical Reaction in a Patient with Hidradenitis Suppurativa Undergoing Adalimumab Treatment. International journal

    Soichiro Ikeya, Takuya Takeichi, Tomoki Taki, Yoshinao Muro, Tomoo Ogi, Masashi Akiyama

    Acta dermato-venereologica   Vol. 101 ( 6 ) page: adv00484   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2340/00015555-3844

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  23. Successful dupilumab treatment for ichthyotic and atopic features of Netherton syndrome. International journal

    Chiaki Murase, Takuya Takeichi, Tomoki Taki, Takenori Yoshikawa, Akiko Suzuki, Tomoo Ogi, Yasushi Suga, Masashi Akiyama

    Journal of dermatological science   Vol. 102 ( 2 ) page: 126 - 129   2021.5

  24. Association of Topical Minoxidil With Autosomal Recessive Woolly Hair/Hypotrichosis Caused by LIPH Pathogenic Variants. Reviewed International journal

    Tomoki Taki, Kana Tanahashi, Takuya Takeichi, Takenori Yoshikawa, Yuya Murase, Kazumitsu Sugiura, Masashi Akiyama

    JAMA dermatology   Vol. 156 ( 10 ) page: 1030 - 1032   2020.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1001/jamadermatol.2020.2195

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  25. A case of pemphigus with anti-desmoglein 3 and anti-desmocollin 2 and 3 autoantibodies, associated with follicular lymphoma and bronchiolitis obliterans. Reviewed International journal

    Masato Yoshikawa, Takuya Takeichi, Tomoki Taki, Fumihiko Hayakawa, Norito Ishii, Takashi Hashimoto, Yoshinao Muro, Masashi Akiyama

    European journal of dermatology : EJD   Vol. 30 ( 4 ) page: 424 - 425   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1684/ejd.2020.3812

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  26. A patient with bullous pemphigoid with mucosal involvement serologically positive for anti-BP230 autoantibodies only. Reviewed International journal

    T Taki, T Takeichi, M Kono, K Sugiura, Y Sugimura, N Ishii, T Hashimoto, M Akiyama

    The British journal of dermatology   Vol. 182 ( 1 ) page: 221 - 223   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/bjd.18343

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  27. Oculodentodigital Dysplasia Diagnosed from Severe Hypotrichosis. Reviewed International journal

    Tomoki Taki, Takuya Takeichi, Kazumitsu Sugiura, Masashi Akiyama

    Acta dermato-venereologica   Vol. 99 ( 13 ) page: 1307 - 1308   2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2340/00015555-3277

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  28. Roles of aberrant hemichannel activities due to mutant connexin26 in the pathogenesis of KID syndrome Reviewed International journal

    Taki, T., Takeichi, T., Sugiura, K., Akiyama, M.

    Scientific Reports   Vol. 8 ( 1 ) page: 12824   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-30757-3

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  29. Image Gallery: Unilaterally dominant acrokeratoelastoidosis (punctate palmoplantar keratoderma type 3) Reviewed International journal

    T. Taki, Y. Ogawa, A. Sakakibara, M. Kono, M. Akiyama

    BRITISH JOURNAL OF DERMATOLOGY   Vol. 177 ( 4 ) page: E157 - E157   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    DOI: 10.1111/bjd.15817

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  30. Mutational analysis of 29 patients with autosomal-recessive woolly hair and hypotrichosis: LIPH mutations are extremely predominant in autosomal-recessive woolly hair and hypotrichosis in Japan Reviewed International journal

    T. Takeichi, K. Tanahashi, T. Taki, M. Kono, K. Sugiura, M. Akiyama

    BRITISH JOURNAL OF DERMATOLOGY   Vol. 177 ( 1 ) page: 290 - 292   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    DOI: 10.1111/bjd.15070

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  31. Syndactyly type III and hypotrichosis in oculodentodigital syndrome with GJA1 mutation

    T. Taki, T. Takeichi, K. Sugiura, M. Akiyama

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   Vol. 137 ( 5 ) page: S151 - S151   2017.5

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    Language:English   Publisher:ELSEVIER SCIENCE INC  

    DOI: 10.1016/j.jid.2017.02.908

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  32. Image Gallery: Palmoplantar hyperkeratosis in dermatomyositis with anti-PM/Scl antibodies Reviewed International journal

    T. Taki, Y. Muro, Y. Ogawa, M. Akiyama

    BRITISH JOURNAL OF DERMATOLOGY   Vol. 176 ( 5 ) page: E94 - E94   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    DOI: 10.1111/bjd.15371

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MISC 19

  1. Dorfman-Chanarin症候群の病態解明と新規治療薬の開発

    滝 奉樹, 武市 拓也, 秋山 真志

    日本皮膚科学会雑誌   Vol. 132 ( 5 ) page: 1374 - 1374   2022.5

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  2. 【診断に苦慮した症例】診断に苦慮したメトトレキサート関連リンパ増殖異常症

    岩田 真衣, 山田 元人, 藤原 慎二, 滝 奉樹, 山下 雄太, 藤城 里香

    皮膚病診療   Vol. 44 ( 1 ) page: 72 - 75   2022.1

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    Language:Japanese   Publisher:(株)協和企画  

    <文献概要>症例のポイント ・メトトレキサート(methotrexate:MTX)内服中に難治性の潰瘍が出現し,徐々に腫瘤となった.・悪性を強く疑う経過だったが,診断に至るまでに時間を要した.・悪性を疑う場合は他臓器病変の検索を検討する.・内服薬や病歴を病理医と共有することも,診断において重要である.

  3. レゴラフェニブに起因する手足症候群対策における効果的介入 既治療による皮膚障害が残存していた2事例からの検討

    牧野 佐知子, 深津 美緒, 吉田 友紀, 池戸 美奈, 滝 奉樹, 脇田 恵里, 尾納 明里紗, 伊藤 武, 安藤 雅規, 山下 克也

    国立病院総合医学会講演抄録集   Vol. 75回   page: 960 - 960   2021.10

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    Language:Japanese   Publisher:国立病院総合医学会  

  4. dupilumabが奏功したNetherton症候群の1例

    秋山 真志, 村瀬 千晶, 滝 奉樹, 武市 拓也, 須賀 康

    日本皮膚科学会雑誌   Vol. 131 ( 8 ) page: 1893 - 1894   2021.7

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  5. 末梢神経障害を合併し生体肝移植で改善を認めた骨髄性プロトポルフィリン症の1例

    村尾 厚徳, 原 一洋, 熱田 直樹, 雫 真人, 小倉 靖弘, 茜部 穂波, 滝 奉樹, 勝野 雅央

    臨床神経学   Vol. 61 ( 6 ) page: 424 - 424   2021.6

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  6. 末梢神経障害を合併し生体肝移植で改善を認めた骨髄性プロトポルフィリン症の1例

    村尾 厚徳, 原 一洋, 熱田 直樹, 雫 真人, 小倉 靖弘, 茜部 穂波, 滝 奉樹, 勝野 雅央

    臨床神経学   Vol. 61 ( 6 ) page: 424 - 424   2021.6

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  7. 巨大な悪性増殖性外毛根鞘性腫瘍の1例

    近藤 綾子, 森 章一郎, 茜部 穂波, 奥村 真央, 浦田 透, 村上 佳恵, 横田 憲二, 滝 奉樹, 秋山 真志, 後藤 啓介

    日本皮膚科学会雑誌   Vol. 130 ( 12 ) page: 2591 - 2591   2020.11

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  8. LIPH創始者変異により偽性優性遺伝形式を示した先天性乏毛症の1家系

    滝 奉樹, 棚橋 華奈, 武市 拓也, 秋山 真志

    日本皮膚科学会雑誌   Vol. 130 ( 12 ) page: 2585 - 2585   2020.11

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  9. 特定行為研修終了後の皮膚・排泄ケア認定看護師の役割活動に関する一考察

    池戸 美奈, 佐竹 康子, 滝 奉樹, 羽根 啓朗, 横井 俊介, 柴田 康宏, 酒井 秀樹, 山下 克也

    国立病院総合医学会講演抄録集   Vol. 74回   page: P - 260   2020.10

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    Language:Japanese   Publisher:国立病院総合医学会  

  10. 血清学的に抗BP230抗体単独陽性で、粘膜病変を有した水疱性類天疱瘡の1例

    滝 奉樹, 武市 拓也, 河野 通浩, 秋山 真志, 杉浦 一充, 椙村 有里子, 石井 文人, 橋本 隆

    日本皮膚科学会雑誌   Vol. 130 ( 3 ) page: 411 - 412   2020.3

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  11. 経口抗がん薬(レゴラフェニブ)導入準備におけるチームの取り組み 手足症候群に対する投与前からの多職種協働マップを作成して

    牧野 佐知子, 深津 美緒, 芳賀 未来, 武藤 美代子, 池戸 美奈, 井上 英美, 中村 曜子, 古田 はるか, 平野 理恵, 滝 奉樹, 伊藤 武, 山下 克也

    医療の広場   Vol. 59 ( 11 ) page: 28 - 31   2019.11

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    Language:Japanese   Publisher:(公財)政策医療振興財団  

    レゴラフェニブ外来導入に向けたチームの取り組みとして、手足症候群に対する投与前からの多職種協働マップを作成した。多職種協働マップ作成を進める中で、各職種が役割意識を高め、チームとして成長することができた。更に今回の取り組みは新規レジメンの安全で円滑な導入を可能にし、効果的な副作用管理に貢献し得ることが示唆された。

  12. 上腕の潰瘍を呈した続発性皮膚クリプトコッカス症の1例 International journal

    田中 陽奈, 滝 奉樹, 安田 公美, 影山 潮人, 榊原 章浩, 岩舘 知史

    皮膚科の臨床   Vol. 61 ( 3 ) page: 427 - 431   2019.3

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    Language:Japanese   Publisher:金原出版(株)  

    <文献概要>42歳,女性。大動脈炎症候群,関節リウマチでプレドニゾロン8mg,タクロリムス1mgを内服し,慢性腎不全で血液透析を受けていた。半年前より左上腕に紅色結節が出現し,近医で切開後に潰瘍を形成したため当科を受診した。初診時,上腕外側に30×25mm大の潰瘍があり,病理組織でPASおよびGrocott染色陽性の円形菌体を認め,培養でCryptococcus neoformansを同定した。血清Cryptococcus neoformans抗原陽性,肺・神経病変を認めず外傷歴もないことから,続発性皮膚クリプトコッカス症と診断した。フルコナゾール内服とアムホテリシンB外用にて軽快した。本症例では皮膚クリプトコッカス症の分類を再考し,また有用な治療法の一案を提示した。

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J01266&link_issn=&doc_id=20190320030039&doc_link_id=10.18888%2Fhi.0000001279&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fhi.0000001279&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  13. レゴラフェニブによる副作用マネジメントにおいてセルフケア行動の改善をもたらしたチーム活動 手足症候群への予防的介入を通して International journal

    深津 美緒, 牧野 佐知子, 藤岡 恭子, 新井 三紗子, 伊藤 武, 滝 奉樹, 山下 克也, 平野 理恵, 井上 英美

    国立病院総合医学会講演抄録集   Vol. 72回   page: 944 - 944   2018.11

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  14. 経口抗がん薬(レゴラフェニブ)導入準備におけるチームの取り組み 手足症候群に対する投与前からの多職種協働マップを作成して International journal

    牧野 佐知子, 深津 美緒, 芳賀 未来, 武藤 美代子, 池戸 美奈, 井上 英美, 中村 曜子, 古田 はるか, 滝 奉樹, 平野 理恵, 山下 克也

    国立病院総合医学会講演抄録集   Vol. 72回   page: 214 - 214   2018.11

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  15. 【足趾の皮膚病】<臨床例>足趾の有痛性紅斑を呈した食道癌皮膚転移 International journal

    田中 陽奈, 滝 奉樹, 安田 公美, 影山 潮人, 榊原 章浩, 脇田 重徳

    皮膚病診療   Vol. 40 ( 4 ) page: 409 - 412   2018.4

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    Language:Japanese   Publisher:(株)協和企画  

    <症例のポイント>・食道癌の皮膚転移は2%程度とまれであり、そのうち自験例のような指趾への転移はまれである。・転移性皮膚癌の臨床所見は、Brownstein &amp; Helwigの分類によると結節型、炎症型、皮膚硬化型の3つに分類される。担癌患者の難治性の皮膚症状の鑑別として、転移性皮膚癌も多彩な臨床所見があることを念頭に鑑別に入れる必要がある。・転移性皮膚癌の治療法は、患者のQOLを重視して決定されなければならない。(著者抄録)

  16. Syndactyly type III and hypotrichosis in oculodentodigital syndrome with GJA1 mutation International journal

    T. Taki, T. Takeichi, K. Sugiura, M. Akiyama

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   Vol. 137 ( 5 ) page: S151 - S151   2017.5

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:ELSEVIER SCIENCE INC  

    Web of Science

  17. 濾胞性リンパ腫を伴った抗デスモグレイン(Dsg)3、デスモコリン(Dsc)2、3抗体陽性天疱瘡 International journal

    吉川 真人, 武市 拓也, 滝 奉樹, 室 慶直, 秋山 真志, 早川 文彦, 石井 文人, 橋本 隆

    日本皮膚科学会雑誌   Vol. 127 ( 3 ) page: 483 - 483   2017.3

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  18. 抗PM/Scl抗体陽性皮膚筋炎の3例はじめに International journal

    桃原 真理子, 室 慶直, 滝 奉樹, 小川 靖, 杉浦 一充, 秋山 真志, 岡地 祥太郎, 曽根 淳

    中部リウマチ   Vol. 46 ( 2 ) page: 37 - 37   2017.3

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  19. 過去2回腹部皮膚腫瘍を摘出した部位に23年後に生じた隆起性皮膚線維肉腫の1例 International journal

    杉本 昌世, 滝 奉樹, 藤田 陽奈, 影山 潮人, 榊原 章浩

    日本皮膚科学会雑誌   Vol. 127 ( 2 ) page: 202 - 203   2017.2

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Presentations 7

  1. Darier disease successfully treated with a topical agent containing vitamin A (retinyl palmitate), vitamin E and urea International conference

    Taki T, Miyazaki A, Takeichi T, Kono M, Yagi H, Akiyama M

    The 47th Annual Meeting of the Japanese Society for Investigative Dermatology  2022.12.3  Japanese Society for Investigative Dermatology

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    Event date: 2022.12

    Language:English   Presentation type:Poster presentation  

    Venue:Nagasaki   Country:Japan  

  2. Low plasma fibrinogen levels are associated with poor prognosis in cutaneous angiosarcoma of the head and neck. International conference

    Taki T, Mori S, Murakami Y, Urata T, Okumura M, Akanabe H, Ebata A, Imai S, Yokota K, Akiyama M

    The 51st European Society for Dermatological Research Annual Meeting.  2022.1.3  European Society for Dermatological Research

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    Event date: 2022.10 - 2022.11

    Language:English   Presentation type:Poster presentation  

    Venue:Amsterdam, Netherlands   Country:Netherlands  

  3. 経口抗がん薬(レゴラフェニブ)導入時準備におけるチームの取り組み~手足症候群に対する投与前からの多職種協働マップを作成して~

    牧田佐知子, 深津美緒, 芳賀未来, 武藤美佐子, 池戸美奈, 井上英美, 中村曜子, 吉田はるか, 滝奉樹, 平野理恵, 山下克也

    第72回国立病院総合医学会  2018.11.9 

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    Language:Japanese   Presentation type:Poster presentation  

  4. レゴラフェニブによる副作用マネジメントにおいてセルフケア行動の改善をもたらしたチーム活動~手足症候群への予防的介入を通して~

    深津美緒, 牧田佐知子, 新井三紗子, 伊藤武, 滝奉樹, 山下克也, 平野理恵, 井上英美

    第72回国立病院総合医学会  2018.11.9 

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    Language:Japanese   Presentation type:Poster presentation  

  5. Syndactyly type III and hypotrichosis in oculodentodigital syndrome with GJA1 mutation

    Tomoki Taki, Takeichi Takuya, Sugiura Kazumitsu, Akiyama Masashi

    The 76th Society for Investigative Dermatology Annual Meeting  2017.4.28 

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    Language:English   Presentation type:Poster presentation  

  6. Roles of aberrant hemichannel activities due to mutant connexin26 in the pathogenesis of KID syndrome

    Tomoki Taki, Takeichi Takuya, Kazumitsu Sugiura, Masashi Akiyama

    The 49th European Society for Dermatological Research Annual Meeting  2019.9.18 

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    Language:English   Presentation type:Poster presentation  

  7. Roles of aberrant hemichannel activities due to mutant connexin26 in the pathogenesis of KID syndrome

    Tomoki Taki, Takeichi Takuya, Sugiura Kazumitsu, Akiyama Masashi

    第32回 表皮細胞研究会  2018.11.23 

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    Language:English   Presentation type:Oral presentation (general)  

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Research Project for Joint Research, Competitive Funding, etc. 4

  1. アレルゲン特異的IgG4抗体の脱感作における機能解析と新規治療法の開発

    2023.4 - 2024.4

    JSA WAO 2020 記念 研究助成プログラム 

    桃原真理子 , 江畑葵 , 宮崎朗

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    Authorship:Principal investigator  Grant type:Competitive

  2. アジア人に多い皮膚悪性腫瘍、乳房外パジェット病のAI技術による予後予測

    2022.7 - 2023.7

    第47回がんその他の悪性新生物研究助成金 

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    Authorship:Principal investigator  Grant type:Competitive

  3. 皮膚血管肉腫に対するセルフリーDNAを用いたリキッドバイオプシーの開発

    2020.12 - 2021.12

    2020年度堀財団先端研究支援経費  

    森章一郎

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    Authorship:Principal investigator  Grant type:Competitive

  4. Dorfman-Chanarin症候群の病因因子ABHD5の病態解明と新規治療薬の開発

    令和2年度日本研究皮膚科学会基礎医学研究費(資生堂寄付)  

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    Authorship:Principal investigator  Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. Pathogenesis analysis and exploration of novel therapeutic strategies for Dorfman-Chanarin syndrome.

    Grant number:23K15282  2023.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

  2. Elucidation of crosstalk between epidermal lipid abnormality/barrier defects and inflammation in ichthyosis for innovation of novel treatments

    Grant number:21H02941  2021.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s) 

  3. Innovation of novel therapeutic strategies using siRNA for ichthyotic lesions of KID syndrome

    Grant number:20K17315  2020.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )