研究者詳細 - 玉腰　浩司

論文 - 玉腰　浩司

分割表示 199 件中 81 - 100 件目／全件表示 >>

Body mass index-modified relationship of chronic mental stress with resting blood pressure during 5 years in Japanese middle-aged male workers. 査読有り

TOYOSHIMA hideaki, OTSUKA Rei, HASHIMOTO Shuji, RAMAKOSHI Koji, YATSUYA Hiroshi

Circulation Journal 78 巻 ( 6 ) 頁： 1379-1386 2014年4月

Factors associated with early postpartum maternity blues and depression tendency among Japanese mothers with full-term healthy infants. 査読有り

TAKAHASHI Yuki, TAMAKOSHI Koji

Nagoya J Med Sci 76 巻 ( 1-2 ) 頁： 129-138 2014年2月

Learning disability in 10- to 16-year-old adolescents with very low birth weight in Japan. 査読有り

TANABE Keiko, TAMAKOSHI Koji, KIKUCHI Saya, MUROTSUKI Jun

Tohoku J Exp Med. 232 巻 ( 1 ) 頁： 27-33 2014年1月

Positive association between high-sensitivity C-reactive protein and incidence of type 2 diabetes mellitus in Japanese workers: 6-year follow-up 査読有り

WANG Chaochen, YATSUYA Hiroshi, TAMAKOSHI Koji, UEMURA Mayu, LI Yuanying, WADA Keiko, YAMASHITA Kentaro, KAWAGUCHU Leo, TOYOSHIMA Hideaki, AOYAMA Atsuko

Diabetes Metab Res Rev 29 巻 ( 5 ) 頁： 398-405 2013年7月

Ovarian cancer mortality among women aged 40-79 years in relation to reproductive factors and body mass index: latest evidence from the Japan Collaborative Cohort study 査読有り

KHAN Md. Mobarak Hossain, KHAN Aklimunnessa, NOJIMA Masahiro, SUZUKI Sadao, FUJINO Yoshihisa, TOKUDOME Shinkan, TAMAKOSHI Koji, MORI Mitsuru, TAMAKOSHI Akiko

J Gynecol Oncol 24 巻 ( 3 ) 頁： 249-257 2013年7月

Obesity/weight gain and breast cancer risk: findings from the Japan collaborative cohort study for the evaluation of cancer risk. 査読有り

SUZUKI Sadao, KOJIMA Masayo, TOKUDOME Shinkan, MORI Mitsuru, SAKAUCHI Fumio, WAKAI Kenji, FUJINO Yoshihisa, LIN Yingsong, KIKUCHI Shogo, TAMAKOSHI Koji, TAMAKOSHI Akiko

J Epidemiol 23 巻 ( 2 ) 頁： 139-145 2013年2月

Associations of protein, fat, and carbohydrate intakes with insomnia symptoms among middle-aged Japanese workers. 査読有り

TANAKA Eizaburo, YATSUYA Hiroshi, UEMURA Mayu, OTSUKA Rei, TOYOSHIMA Hideaki, TAMAKOSHI Koji, SASAKI Satoshi, KAWAGUCHI Leo, AOYAMA Atsuko

J Epidemiol 23 巻 ( 2 ) 頁： 132-138 2013年2月

Multiple roles and all-cause mortality: the Japan Collaborative Cohort Study 査読有り

TAMAKOSHI Akiko, IKEDA Ai, FUJINO Yoshihisa, TAMAKOSHI Koji, ISO Hiroyasu

Eur J Public Health 2013年2月

Characteristics of hypertension-related factors in female home caregivers in Japan-comparison with general community non-caregivers. 査読有り

HOSHINO Junko, HORI Yoko, KONDO Takaaki, TAMAKOSHI Koji, TOYOSHIMA Hideaki, SAKAKIBARA Hisataka

J Clin Nurs 2013年2月

Validation of the prediction model for success of vaginal birth after cesarean delivery in Japanese women. 査読有り

YOKOI Akira, ISHIKAWA Kaoru, MIYAZAKI Ken, TOSHIDA Kana, FYRUHASHI Madoka, TAMAKOSHI Koji

Int J Med Sci 9 巻 ( 6 ) 頁： 488-491 2012年8月

Inverse relationship of serum adiponectin concentration with type 2 diabetes mellitus incidence in middle-aged Japanese workers: six-year follow-up. 査読有り

LI Yuanying, YATSUYA Hiroshi, ISO Hiroyasu, TOYOSHIMA Hideaki, TAMAKOSHI Koji

Diabetes Metab Res Rev 28 巻 ( 4 ) 頁： 349-356 2012年5月

Multiple roles and all-cause mortality: the Japan Collaborative Cohort Study. 査読有り

TAMAKOSHI Akiko, IKEDA Ai, FUJINO Yoshihisa, TAMAKOSHI Koji, ISO Hiroyasu

Eur J Public Health 2012年1月

Inverse relationship of serum adiponectin concentration with type 2 diabetes mellitus incidence in middle-aged Japanese workers: 6-year follow-up 査読有り

LI Yuanying, HATSUYA Hiroshi, ISO Hiroyasu, TOYOSHIMA Hideaki, TAMAKOSHI Koji

Diabetes Metab Res Rev 2012年1月

Spectrin αII and βII tetramers contribute to platinum anticancer drug resistance in ovarian serous adenocarcinoma 査読有り

MAEDA Osamu, SHIBATA Kiyosumi, HOSONO Satoyo, FUJIWARA Sawako, KAJIYAMA Hiroaki, INO Kazuhiko, NAWA Akihiro, TAMAKOSHI Koji, KIKKAWA Fumitaka

Int J Cancer 頁： 113 - 121 2012年1月

Spectrin αII and βII tetramers contribute to platinum anticancer drug resistance in ovarian serous adenocarcinoma 査読有り

MAEDA Osamu, SHIBATA Kiyosumi, HOSONO Satoyo, FUJIWARA Sawako, KAJIYAMA Hiroaki, INO Kazuhiko, NAWA Akihiro, TAMAKOSHI Koji, KIKKAWA Fumitaka

Int J Cancer 130 巻 ( 1 ) 頁： 113-121 2012年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

PMID:21328338
To overcome drug resistance in ovarian carcinoma, novel resistance mechanisms must be elucidated for clinical application. We purified 2 proteins in the 300 kDa range from cisplatin-resistant cells (NOS2CR2) by affinity chromatography with cisplatin-exposed Glutathione Sepharose 4B. The purified proteins were identified as spectrin αII and βII by peptide mass mapping analysis. Western blot analysis detected greater expression of spectrin αII and βII in NOS2CR2 than in wild-type cells (NOS2). The same result was obtained for spectrin βII expression by immunohistochemical staining. To determine whether spectrin αII and βII contribute to resistance, a drug sensitivity test was performed on SKOV3 ovarian cancer cells transfected with small interfering RNA. Sensitivity to platinum drugs was increased in the expression reduced cells. In a clinical study of five ovarian serous adenocarcinoma cases, tumor specimens taken after treatment with carboplatin stained more strongly for spectrin βII expression than untreated specimens. Fifty-two tumor specimens from 46 patients with ovarian serous adenocarcinoma were immunohistochemically stained for spectrin βII and scored. Tumors previously treated by chemotherapy scored higher than those not treated. Of 27 cases with detectable residual tumors at the time of surgery, cases scoring 4-6 had shorter progression-free survival periods after platinum-based chemotherapy than cases scoring 0-3 (p = 0.012). The cytoskeleton proteins Spectrin αII and βII contributed to drug resistance by anchoring the GS-Pt complex to the cell membrane, arresting cisplatin activity. Thus spectrin βII may be a useful predictor of platinum sensitivity in ovarian serous adenocarcinoma.

DOI： 10.1002/ijc.25983

Epidemiologic study of clinically amyopathic dermatomyositis and anti-melanoma differentiation-associated gene 5 antibodies in central Japan. 査読有り

MURO Yoshinao, SUGIURA Kazumitsu, HOSHINO Kei, AKIYAMA Masashi, TAMAKOSHI Koji

Arthritis Res Ther 13 巻 ( 6 ) 頁： 214 2011年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: Several reports have found the onset or activity of inflammatory myopathies to show spatial clustering and seasonal association. We recently detected autoantibodies against melanoma differentiation-associated gene 5 (MDA-5) in more than 20% of patients with dermatomyositis. Anti-MDA-5 antibodies were associated with the presence of rapidly progressive interstitial lung disease in clinically amyopathic dermatomyositis (CADM). The present study aims to assess the growing prevalence of CADM and the geographical incidence of anti-MDA-5-positive patients.

METHODS: We reviewed medical charts and examined the presence of anti-MDA-5 antibodies in 95 patients, including 36 CADM patients. Sera were obtained from 1994 through 2011. Statistical analyses were performed to assess whether CADM development and the presence of anti-MDA-5 antibodies were associated with various parameters, including age at disease onset, season of onset, annual positivity, and population of resident city.

RESULTS: Tertiles based on the year when the sera were collected showed increasing tendencies of CADM and anti-MDA-5-positive patients among all of the dermatomyositis patients. From 1994 to 2010, the relative prevalence of CADM and anti-MDA-5 antibody-positive patients significantly increased. Interestingly, the presence of anti-MDA-5 antibodies in 26 patients was inversely associated with the population of their city of residence.

CONCLUSIONS: This is the first study to examine the distribution of anti-MDA-5-positive dermatomyositis phenotypes in Japan. Regional differences in the incidences of these phenotypes would suggest that environmental factors contribute to the production of antibodies against MDA-5, which triggers innate antiviral responses.

Number of children and all-cause mortality risk: results from the Japan Collaborative Cohort Study 査読有り

TAMAKOSHI Akiko, TAMAKOSHI Koji, LIN Yingsong, MIKAMI Haruo, INABA Yutaka, YAGYU Kiyoko, KIKUCHI Syogo; for the JACC Study Group.

Number of children and all-cause mortality risk: results from the Japan Collaborative Cohort Study 頁： 732 - 737 2011年12月

女性における家族介護者の高血圧自覚の有無による血圧管理状況査読有り

鈴木洋子, 堀容子, 星野純子, 濱本律子, 杉山晃子, 岡田武, 永井邦芳, 近藤高明, 玉腰浩司, 岡本和士, 長澤伸江, 豊嶋英明, 榊原久孝

日本公衆衛生雑誌 58 巻 ( 12 ) 頁： 1016-1025 2011年12月

Early age at menarche associated with increased all-cause mortality 査読有り

TAMAKOSHI Koji, HATSUYA Hiroshi, TAMAKOSHI Akiko

Eur J Epidemiol 2011年10月

Maternal mental disorders and pregnancy outcomes: A clinical study in a Japanese population 査読有り

HIRONAKA Masae, KOTANI Tomomi, SUMIGAMA Seiji, TSUDA Hiroyuki, MANO Yukio, HAYAKAWA Hiromi, TANAKA Satoshi , OZAKI Norio, TAMAKOSHI Koji, KIKKAWA Fumitaka

J Obstet Gynaecol Res 37 巻 ( 10 ) 頁： 1283-1289 2011年10月

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