研究者詳細 - 岡島　徹也

論文 - 岡島　徹也

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Serum and monoclonal IgE antibodies from NC/Nga mice with severe atopic-like dermatitis recognize an autoantigen, histone H3. 査読有り

Matsubara T, Aoki N, Hino H, Okajima T, Nadano D, Matsuda T

Clin. Exp. Allergy 39 巻頁： 579-590 2008年

Absorption, Migration and Kinetics in Peripheral Blood of Orally Administered Ovalbumin in a Mouse Model 査読有り

Matsubara T, Aoki N, Honjoh T, Mizumachi K, Kurisaki JI, Okajima T, Nadano D, Matsuda T

Biosci. Biotechnol. Biochem. 72 巻頁： 2555-2565 2008年

Suppressive expression of the glutelin A1-collagen peptide fusion gene in hybrid rice lines with the mutant line, Low Glutelin Content-1 (LGC-1) 査読有り

Hashizume F, Hino S, Okajima T, Nadano D, Aoki N and Matsuda T

Plant Biotechnol 25 巻頁： 465-471 2008年

Development and evaluation of transgenic rice seeds accumulating a type II-collagen tolerogenic peptide 査読有り

Hashizume F, Hino S, Kakehashi M, Okajima T , Nadano D, Aoki N, and Matsuda T

Transgenic Research 17 巻頁： 1117-1129 2008年

Glycoconjugate glycosyltransferases 招待有り査読有り

Furukawa K, Tsuchida A, Okajima T, Furukawa K

Glycoconj. J 26 巻頁： 987-98 2008年

Engineering of a mammalian O-glycosylation pathway in the yeast Saccharomyces cerevisiae: production of O-fucosylated epidermal growth factor domains 査読有り

Yuko Chigira, Takuji Oka, Tetsuya Okajima and Yoshifumi Jigami

Glycobiology 18 巻頁： 303-314 2008年

Association of chicken zona pellucida glycoprotein (ZP) B1 with ZPC induces formation of ZPB1-ZPC fibrous aggregates containing disulfide-bridged ZPB1 dimer. 査読有り

Okumura H, Okajima T, Nadano D, Matsuda T.

Biochem Biophys Res Commun. 364 巻 ( 3 ) 頁： 682-688 2007年12月

Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis. 査読有り

Miyoshi M, Okajima T, Matsuda T, Fukuda MN, Nadano D.

Biochem J 404 巻 ( 3 ) 頁： 373-381 2007年6月

Roles of fucosyltransferase and fucose in Notch signaling 招待有り

Okajima T, Matuda T.

Methods Enzymol 417 巻頁： 116-26 2006年

*Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding. 査読有り

Okajima T, Xu A, Lei L, Irvine KD.

Science 307 巻頁： 1599-603 2005年3月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Notch proteins are receptors for a conserved signaling pathway that affects numerous cell fate decisions. We found that in Drosophila, Protein O-fucosyltransferase 1 (OFUT1), an enzyme that glycosylates epidermal growth factor-like domains of Notch, also has a distinct Notch chaperone activity. OFUT1 is an endoplasmic reticulum protein, and its localization was essential for function in vivo. OFUT1 could bind to Notch, was required for the trafficking of wild-type Notch out of the endoplasmic reticulum, and could partially rescue defects in secretion and ligand binding associated with Notch point mutations. This ability of OFUT1 to facilitate folding of Notch did not require its fucosyltransferase activity. Thus, a glycosyltransferase can bind its substrate in the endoplasmic reticulum to facilitate normal folding.

*Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe. 招待有り査読有り

Okajima T, Xu A, Irvine KD.

J Biol Chem. 278 巻頁： 42340-5 2003年10月

Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. 査読有り

Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K.

J Biol Chem. 278 巻頁： 22787-94 2003年6月

XGalT-1 involved in the synthesis of glyosaminoglycans of proteoglycans and Ehlers-Danlos syndrome (progeroid type) 招待有り

Furukawa K, Okajima T, Nakamura Y.

Tanpakushitsu Kakusan Koso. 48 巻 ( 8 Suppl ) 頁： 1152-7 2003年1月

*Regulation of notch signaling by O-linked fucose. 招待有り査読有り

Okajima T, Irvine KD.

Cell 111 巻頁： 893-904 2002年12月

Galactosyltransferase I is a gene responsible for progeroid variant of Ehlers-Danlos syndrome: molecular cloning and identification of mutations. 招待有り

Furukawa K, Okajima T.

Biochim Biophys Acta. 1573 巻 ( 3 ) 頁： 377-81 2002年12月

Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis. 査読有り

Nakamura Y, Haines N, Chen J, Okajima T, Furukawa K, Urano T, Stanley P, Irvine KD, Furukawa K.

J Biol Chem. 277 巻 ( 48 ) 頁： 46280-8 2002年11月

b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. 査読有り

Okada M, Itoh Mi M, Haraguchi M, Okajima T, Inoue M, Oishi H, Matsuda Y, Iwamoto T, Kawano T, Fukumoto S, Miyazaki H, Furukawa K, Aizawa S, Furukawa K.

J Biol Chem. 277 巻 ( 3 ) 頁： 1633-6 2002年1月

Expression cloning of human globoside synthase cDNAs: Identification of β3Gal-T3 as UDP-N-acetylgalactosamine: globotriaosylceramide β1,3-N-acetyl-galactosaminyltransferase. 査読有り

Okajima T, Nakamura Y, Uchikawa M, Haslam DB, Numata Si, Furukawa K, Urano T, Furukawa K

J. Biol. Chem. 275 巻頁： 40498-40503 2000年

Molecular cloning and expression of mouse GD1α/GT1aα/GQ1bα synthase (ST6GalNAc VI) gene. 査読有り

Okajima T, Chen HH, Ito H, Kiso M, Tai T, Furukawa K, Urano T, Furukawa K.

J. Biol. Chem. 275 巻頁： 6717-6723 2000年

Molecular cloning of Gb3/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo-series glycosphingolipids. 査読有り

Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.

J. Biol. Chem. 275 巻頁： 15152-15156 2000年

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論文 - 岡島　徹也