研究者詳細 - 岡島　徹也

論文 - 岡島　徹也

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Characterization of galactosyltransferase and sialyltransferase genes mediating the elongation of the extracellular O-GlcNAc glycans.

Tsukamoto Y, Tsukamoto N, Saiki W, Tashima Y, Furukawa JI, Kizuka Y, Narimatsu Y, Clausen H, Takeuchi H, Okajima T

Biochemical and biophysical research communications 703 巻頁： 149610 2024年4月

Efficient Escorting Strategy for Aggregation-Prone Notch EGF Repeats with Sparcl1

Kondo, Y; Li, YX; Okajima, T

MOLECULES 29 巻 ( 5 ) 2024年3月

3'-Sialyllactose on Notch: Notch1 functions as a scaffold of O-linked, 3'-sialyllactosylated glycans

Tsukamoto, Y; Aoki, K; Narimatsu, Y; Urata, Y; Saiki, W; Tiemeyer, M; Clausen, H; Kurebayashi, Y; Minami, A; Takahashi, T; Okajima, T; Takeuchi, H

GLYCOBIOLOGY 33 巻 ( 11 ) 頁： 977 - 977 2023年12月

Quality control of NOTCH and CRB2 proteins containing epidermal growth factor-like EGF repeats by xylosyl elongation of O-glucose glycans

Takeuchi, H; Mita, Y; Tsukamoto, Y; Saiki, W; Kato, K; Urata, Y; Kurebayashi, Y; Minami, A; Takahashi, T; Hibi, H; Okajima, T

GLYCOBIOLOGY 33 巻 ( 11 ) 頁： 997 - 998 2023年12月

Inhibitory machinery for the functional dystroglycan glycosylation

Kondo, Y; Okajima, T

JOURNAL OF BIOCHEMISTRY 173 巻 ( 5 ) 頁： 333 - 335 2023年5月

Evidence that only EWS among the FET proteins acquires a low partitioning property for the hyperosmotic stress response by O-GlcNAc glycosylation on its low-complexity domain

Kakuo, M; Horii, T; Tonomura, N; Sato, R; Ogawa, M; Okajima, T; Kamemura, K

EXPERIMENTAL CELL RESEARCH 424 巻 ( 1 ) 頁： 113504 2023年3月

Secretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation

Zhang, AL; Tsukamoto, Y; Takeuchi, H; Nishiwaki, K; Tashima, Y; Okajima, T

ANALYTICAL BIOCHEMISTRY 656 巻頁： 114881 2022年11月

Roles of POFUT1 and POGLUT1 for the effective transport of DLK1 to the cell surface

Tashima, Y; Goto, W; Tsukamoto, Y; Ogawa, M; Takeuchi, H; Okajima, T

GLYCOBIOLOGY 32 巻 ( 11 ) 頁： 1002 - 1003 2022年10月

3′-Sialyllactose on Notch: Notch1 functions as a scaffold of O-linked, 3′-sialyllactosylated glycans

Tsukamoto, Y; Aoki, K; Narimatsu, Y; Urata, Y; Saiki, W; Tiemeyer, M; Clausen, H; Kurebayashi, Y; Minami, A; Takahashi, T; Okajima, T; Takeuchi, H

GLYCOBIOLOGY 32 巻 ( 11 ) 頁： 1022 - 1022 2022年10月

Glycoproteomics of NOTCH1 EGF repeat fragments overexpressed with different glycosyltransferases in HEK293T cells reveals insights into O-GlcNAcylation of NOTCH1

Tsukamoto, Y; Ogawa, M; Yogi, K; Tashima, Y; Takeuchi, H; Okajima, T

GLYCOBIOLOGY 32 巻 ( 7 ) 頁： 616 - 628 2022年6月

Significant Roles of Notch O-Glycosylation in Cancer

Wang, WW; Okajima, T; Takeuchi, H

MOLECULES 27 巻 ( 6 ) 2022年3月

Ganglioside GD2 enhances malignant properties of melanoma by co-operating with integrin.

Farhana, Y; Bhuiyan, RH; Ohmi, Y; Horiuchi, M; Okajima, T; Yamamoto, S; Furukawa, K; Furukawa, K

CANCER SCIENCE 113 巻頁： 1104 - 1104 2022年2月

Unique effects of expression of asialo-series ganglioside GD1alpha in human cancer cell lines

Robiul, B; Yesmin, F; Kondo, Y; Ohkawa, Y; Ohmi, Y; Zhang, P; Okajima, T; Furukawa, K; Furukawa, K

CANCER SCIENCE 113 巻頁： 379 - 379 2022年2月

Eogt-catalyzed O-GlcNAcylation

Lo, PW; Okajima, T

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY 34 巻 ( 197 ) 頁： E1 - E6 2022年1月

Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins

Yesmin, F; Bhuiyan, RH; Ohmi, Y; Yamamoto, S; Kaneko, K; Ohkawa, Y; Zhang, P; Hamamura, K; Cheung, NKV; Kotani, N; Honke, K; Okajima, T; Kambe, M; Tajima, O; Furukawa, K; Furukawa, K

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 巻 ( 1 ) 2022年1月

Other Classes of Eukaryotic Glycans

Haltiwanger RS, Wells L, Freeze HH, Jafar-Nejad H, Okajima T, Stanley P, Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Mohnen D, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH

2022年

St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity 査読有り

Thane, P; Ohkawa, Y; Yamamoto, S; Momota, H; Kato, A; Kaneko, K; Natsume, A; Farhana, Y; Ohmi, Y; Okajima, T; Bhuiyan, RH; Wakabayashi, T; Furukawa, K; Furukawa, K

NAGOYA JOURNAL OF MEDICAL SCIENCE 83 巻 ( 3 ) 頁： 535 - 549 2021年8月

Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes 査読有り

Ohmi, Y; Nishikaze, T; Kitaura, Y; Ito, T; Yamamoto, S; Sugiyama, F; Matsuyama, M; Takahashi, Y; Takeda, A; Kawahara, T; Okajima, T; Furukawa, K; Furukawa, K

GLYCOBIOLOGY 31 巻 ( 5 ) 頁： 557 - 570 2021年5月

Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers 査読有り

Barua, R; Mizuno, K; Tashima, Y; Ogawa, M; Takeuchi, H; Taguchi, A; Okajima, T

MOLECULES 26 巻 ( 4 ) 2021年2月

Current Views on the Roles of O-Glycosylation in Controlling Notch-Ligand Interactions 査読有り

Saiki, W; Ma, CY; Okajima, T; Takeuchi, H

BIOMOLECULES 11 巻 ( 2 ) 2021年2月

Roles of asialo-series ganglioside GD1α in human cancer cell lines. 査読有り

Bhuiyan, RH; Yesmin, F; Kondo, Y; Ohkawa, Y; Ohmi, Y; Zhang, P; Okajima, T; Furukawa, K; Furukawa, K

CANCER SCIENCE 112 巻頁： 679 - 679 2021年2月

Ganglioside GD2 enhances malignant properties of melanoma by co-operating with integrin. 査読有り

Yesmin, F; Bhuiyan, RH; Ohmi, Y; Okajima, T; Yamamoto, S; Furukawa, K; Furukawa, K

CANCER SCIENCE 112 巻頁： 699 - 699 2021年2月

Enzyme assay of O-fucosyltransferase 1 using Drosophila OFUT1.

Nishihara S, Angata K, Aoki-Kinoshita KF, Hirabayashi J, Okajima T

2021年

Enzyme assay of O-GlcNAc transferase.

Nishihara S, Angata K, Aoki-Kinoshita KF, Hirabayashi J, Alam SMD, Okajima T

2021年

3′-Sialyllactose on Notch: NOTCH1 functions as a scafold of O-linked, 3′-sialyllactosylated glycans

Tsukamoto, Y; Aoki, K; Narimatsu, Y; Urata, Y; Saiki, W; Ogawa, M; Clausen, H; Tiemeyer, M; Okajima, T; Takeuchi, H

GLYCOBIOLOGY 30 巻 ( 12 ) 頁： 1119 - 1120 2020年12月

N-glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization

Alam, SMD; Tsukamoto, Y; Ogawa, M; Senoo, Y; Ikeda, K; Tashima, Y; Takeuchi, H; Okajima, T

GLYCOBIOLOGY 30 巻 ( 12 ) 頁： 1031 - 1032 2020年12月

Comprehensive O-GlcNAc glycoproteomics on NOTCH1 EGF repeats refined the sequons for O-GlcNAcylation and uncovered unique Lewis X epitopes in mammals

Ogawa, M; Tsukamoto, Y; Yogi, K; Senoo, Y; Ikeda, K; Takeuchi, H; Okajima, T

GLYCOBIOLOGY 30 巻 ( 12 ) 頁： 1086 - 1087 2020年12月

Glycoproteomic analysis identifies cryptdin-related sequence 1 as O-glycosylated protein modified with α1,2-fucose in the small intestine 査読有り

Hashiguchi, H; Tsukamoto, Y; Ogawa, M; Tashima, Y; Takeuchi, H; Nakamura, M; Kawashima, H; Fujishiro, M; Okajima, T

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 695 巻頁： 108653 2020年11月

Differential Labeling of Glycoproteins with Alkynyl Fucose Analogs 査読有り

Ma, CY; Takeuchi, H; Hao, HL; Yonekawa, C; Nakajima, K; Nagae, M; Okajima, T; Haltiwanger, RS; Kizuka, Y

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21 巻 ( 17 ) 2020年9月

Aminoglycosides are efficient reagents to induce readthrough of premature termination codon in mutant B4GALNT1 genes found in families of hereditary spastic paraplegia

Yesmin, F; Bhuiyan, RH; Ohmi, Y; Ohkawa, Y; Tajima, O; Okajima, T; Furukawa, K; Furukawa, K

JOURNAL OF BIOCHEMISTRY 168 巻 ( 2 ) 頁： 103 - 112 2020年8月

N-Glycans on EGF domain-specificO-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization

Alam, SMD; Tsukamoto, Y; Ogawa, M; Senoo, Y; Ikeda, K; Tashima, Y; Takeuchi, H; Okajima, T

JOURNAL OF BIOLOGICAL CHEMISTRY 295 巻 ( 25 ) 頁： 8560 - 8574 2020年6月

Contribution of extracellular O-GlcNAc to the stability of folded epidermal growth factor-like domains and Notch1 trafficking

Ogawa, M; Tashima, Y; Sakaguchi, Y; Takeuchi, H; Okajima, T

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 526 巻 ( 1 ) 頁： 184 - 190 2020年5月

Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking

Urata, Y; Saiki, W; Tsukamoto, Y; Sago, H; Hibi, H; Okajima, T; Takeuchi, H

CELLS 9 巻 ( 5 ) 2020年5月

The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface

Hashimoto, N; Ito, S; Tsuchida, A; Bhuiyan, RH; Okajima, T; Yamamoto, A; Furukawa, K; Ohmi, Y; Furukawa, K

JOURNAL OF BIOLOGICAL CHEMISTRY 294 巻 ( 28 ) 頁： 10833 - 10845 2019年7月

Extracellular O-GlcNAc: From Discovery to Current Developments

Okajima, T

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY 31 巻 ( 181 ) 頁： SE57 - SE58 2019年7月

Structure and function of extracellular O-GlcNAc

Ogawa, M; Okajima, T

CURRENT OPINION IN STRUCTURAL BIOLOGY 56 巻頁： 72 - 77 2019年6月

Loss of Enzyme Activity in Mutated B4GALNT1 Gene Products in Patients with Hereditary Spastic Paraplegia Results in Relatively Mild Neurological Disorders: Similarity with Phenotypes of B4galnt1 Knockout Mice

Bhuiyan, RH; Ohmi, Y; Ohkawa, Y; Zhang, P; Takano, M; Hashimoto, N; Okajima, T; Furukawa, K; Furukawa, K

NEUROSCIENCE 397 巻頁： 94 - 106 2019年1月

Structure and function of extracellular O-GlcNAc 招待有り査読有り

Mitsutaka Ogawa, Tetsuya Okajima

Current Opinion in Structural Biology 56 巻頁： 72-77 2019年

Significant roles of O-glucose glycans in mammalian Notch trafficking and signaling

Takeuchi, H; Yu, HJ; Hao, HL; Urata, Y; Senoo, Y; Tsukamoto, Y; Saiki, W; Takeuchi, M; Ito, A; Li, HL; Okajima, T; Haltiwanger, RS

GLYCOBIOLOGY 28 巻 ( 12 ) 頁： 1017 - 1018 2018年12月

Exploring the significance of xylosyl-extension of O-glucose glycans on EGF repeats for Notch signaling in mammals

Saiki, W; Urata, Y; Senoo, Y; Tsukamoto, Y; Ma, CY; Okajima, T; Takeuchi, H

GLYCOBIOLOGY 28 巻 ( 12 ) 頁： 1028 - 1029 2018年12月

Roles of asialo-series ganglioside GD1alpha in human cancer cell lines

Bhuiyan, RH; Kondo, Y; Ohkawa, Y; Ohmi, Y; Zhang, P; Okajima, T; Furukawa, K; Furukawa, K

CANCER SCIENCE 109 巻頁： 877 - 877 2018年12月

Roles of ganglioside GD3 in the regulation of microenvironment of gliomas

Zhang, P; Ohkawa, Y; Ohmi, Y; Robiul, HB; Kato, A; Furukawa, K; Okajima, T; Wakabayashi, T; Furukawa, K

CANCER SCIENCE 109 巻頁： 262 - 262 2018年12月

Dissection and Whole Mount Staining of Retina from Neonatal Mice.

Ogawa M, Okajima T

Bio-protocol 8 巻 ( 19 ) 頁： e3034 2018年10月

Isolation of Murine Brain and Lung Microvascular Endothelial Cells 招待有り査読有り

Ailing Zhang, Shogo Sawaguchi, Entzu Wan, Mitsutaka Ogawa, Tetsuya Okajima

bio-101 2018年8月

Congenital diseases caused by defective O-glycosylation of Notch receptors

Tashima, Y; Okajima, T

NAGOYA JOURNAL OF MEDICAL SCIENCE 80 巻 ( 3 ) 頁： 299 - 307 2018年8月

Structural Divergence in O-GlcNAc Glycans Displayed on Epidermal Growth Factor-like Repeats of Mammalian Notch1.

Ogawa M, Senoo Y, Ikeda K, Takeuchi H, Okajima T

Molecules (Basel, Switzerland) 23 巻 ( 7 ) 2018年7月

NOTCH SIGNALING A sweet strategy

Okajima, T

NATURE CHEMICAL BIOLOGY 14 巻 ( 1 ) 頁： 3 - 4 2018年1月

Ganglioside GD3/GD2 enhance malignant properties of human glioma U251 cells

Zhang, P; Iwasawa, T; Ohkawa, Y; Bhuiyan, RH; Momota, H; Wakabayashi, T; Ohmi, Y; Okajima, T; Furukawa, K; Furukawa, K

CANCER SCIENCE 109 巻頁： 256 - 256 2018年1月

Protocol for Notch-ligand Binding Assays Using Dynabeads 招待有り査読有り

bio-protocol 2017年10月

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

Sawaguchi, S; Varshney, S; Ogawa, M; Sakaidani, Y; Yagi, H; Takeshita, K; Murohara, T; Kato, K; Sundaram, S; Stanley, P; Okajima, T

ELIFE 6 巻 2017年4月

Neogenin defined as a GD3-associated molecule by enzyme-mediated activation of radical sources confers malignant properties via intra-cytoplasmic domain in melanoma cells. 査読有り

Kaneko K, Ohkawa Y, Hashimoto N, Ohmi Y, Kotani N, Honke K, Ogawa M, Okajima T, Furukawa K, Furukawa K

J. Biol. Chem. 291 巻頁： 16630-16643 2016年

Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated EGF domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome.

Ogawa M, Sawaguchi S, Kawai T, Nadano D, Matsuda T, Yagi H, Kato K, Furukawa K, Okajima T.

J Biol Chem 頁： in press 2015年

O-fucose monosaccharide of Drosophila Notch has a temperature-sensitive function and cooperates with O-glucose glycan in Notch transport and Notch signaling activation. 査読有り

Ishio A, Sasamura T, Ayukawa T, Kuroda J, Ishikawa HO, Aoyama N, Matsumoto K, Gushiken T, Okajima T, Yamakawa T, Matsuno K.

J Biol Chem 頁： in press 2015年

Extracellular O-linked beta-N-acetylglucosamine: Its biology and relationship to human disease. 招待有り査読有り

Ogawa M, Furukawa K, Okajima T.

World J Biol Chem 5 巻頁： 224-230 2014年

Allergenic potential of rice-pollen proteins: expression, immuno-cross reactivity and IgE-binding.

154 巻頁： 195-205 2013年

Dephosphorylation reduces passage of ovalbumin antigen through intestinal epithelial Caco-2 cell monolayers.

153 巻頁： 347-354 2013年

GTDC2 modifies O-mannosylated α-dystroglycan in the endoplasmic reticulum to generate N-acetyl-glucosamine epitopes reactive with CTD110.6 antibody. 査読有り

440 巻頁： 88-93 2013年

Post-weaning increases in the milk-fat globule EGF-factor VIII on fat globules in mouse milk and in the uptake of the fat globules by HC11 mammary epithelial cells. 査読有り

153 巻頁： 31-41 2013年

Trimeric Tn Antigen on Syndecan 1 Produced by ppGalNAc-T13 Enhances Cancer Metastasis via a Complex Formation with Integrin alpha5beta1 and Matrix Metalloproteinase 9. 査読有り

288 巻頁： 24264-24276 2013年

O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1.

419 巻頁： 14-19 2012年

Discharge of solubilized and Dectin-1-reactive beta-glucan from macrophage cells phagocytizing insoluble beta-glucan particles: Involvement of reactive oxygen species (ROS)-driven degradation. 査読有り

421 巻頁： 329-334 2012年

pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen. 査読有り

419 巻頁： 7-13 2012年

O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions 査読有り

2 巻頁： 583 2011年12月

Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin

508 巻頁： 87-92 2011年

Specific O-glycosylation modifying epidermal growth factor domains.

83 巻頁： 813-821 2011年

Strong antibody reaction against glycosphingolipids injected in liposome-embedded forms in beta3GN-T5 knockout mice.

73 巻頁： 137-146 2011年

Establishment of a Mammary Stromal Fibroblastic Cell Line for In Vitro Studies in Mice of Mammary Adipocyte Differentiation. 査読有り

Nakatani H, Aoki N, Okajima T, Nadano D, Flint D, Matsuda T.

Biol. Reprod. 82 巻頁： 44-53 2010年

O-GlcNAc modification on EGF domains of Notch receptors.

Sakaidani Y, Furukawa K, Okajima T.

Methods Enzymol. 480 巻頁： 355-73 2010年

Proteomic Analysis of Rodent Ribosomes Revealed Heterogeneity Including Ribosomal Proteins L10-like, L22-like 1, and L39-like. 査読有り

Sugihara Y, Honda H, Iida T, Morinaga T, Hino S, Okajima T, Matsuda T, Nadano D.

J. Proteome Res. 9 巻頁： 1351-66 2010年

Roles of glycosylation in Notch signaling.

92 巻頁： 131-164 2010年

Binding of Norovirus virus-like particles (VLPs) to human intestinal Caco-2 cells and the sup-pressive effect of pasteurized bovine colostrum on this VLP binding.

74 巻頁： 541-547. 2010年

Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA-binding protein in early involution of the mouse mammary gland.

28 巻頁： 321-328 2010年

IgG2 dominancy and carbohydrate recognition specificity of C3H/He mouse antibodies directed to cross-reactive carbohydrate determinants (CCDs) bearing ß-(1,2)-xylose and α-(1,3)-fucose

133 巻頁： 28-34 2010年

Glycoconjugate glycosyltransferases. 招待有り査読有り

Furukawa K, Tsuchida A, Okajima T, Furukawa K.

Glycoconj. J. 26 巻頁： 987-998 2009年

Periodate-resistant carbohydrate epitopes recognized by IgG and IgE antibodies from some of the immunized mice and patients with allergy. 査読有り

Hino S, Matsubara T, Urisu A, Aoki N, Sato C, Okajima T, Nadano D, Matsuda T.

Biochem. Biophys Res. Commun. 380 巻頁： 632-637 2009年

Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling 査読有り

Okajima T, Reddy B, Matsuda T and Irvine KD

BMC biology 6 巻 ( 1 ) 頁： 1-26 2008年1月

Biological functions of glycosyltransferase genes involved in O-fucose glycan synthesis 招待有り査読有り

Okajima T, Matsuura A, Matsuda T

J. Biochem. 144 巻頁： 1-6 2008年

*O-linked GlcNAc is present on the extracellular domain of Notch receptors. 査読有り

Matsuura A, Ito M, Sakaidani Y, Kondo T, Murakami K, Furukawa K, Nadano D, Matsuda T, and Okajima T

J. Biol. Chem. 283 巻 ( 51 ) 頁： 35486-35495 2008年

Glycosyltransferases involved in O-fucose glycan synthesis.

Okajima T, Matsuda T

Experimental Glycoscience 頁： 33-35 2008年

糖転移酵素のNotch受容体フォールディングにおける役割

松浦愛子・松田幹・岡島徹也

蛋白質核酸酵素 53 巻頁： 1480-1485 2008年

Serum and monoclonal IgE antibodies from NC/Nga mice with severe atopic-like dermatitis recognize an autoantigen, histone H3. 査読有り

Matsubara T, Aoki N, Hino H, Okajima T, Nadano D, Matsuda T

Clin. Exp. Allergy 39 巻頁： 579-590 2008年

Absorption, Migration and Kinetics in Peripheral Blood of Orally Administered Ovalbumin in a Mouse Model 査読有り

Matsubara T, Aoki N, Honjoh T, Mizumachi K, Kurisaki JI, Okajima T, Nadano D, Matsuda T

Biosci. Biotechnol. Biochem. 72 巻頁： 2555-2565 2008年

Suppressive expression of the glutelin A1-collagen peptide fusion gene in hybrid rice lines with the mutant line, Low Glutelin Content-1 (LGC-1) 査読有り

Hashizume F, Hino S, Okajima T, Nadano D, Aoki N and Matsuda T

Plant Biotechnol 25 巻頁： 465-471 2008年

Development and evaluation of transgenic rice seeds accumulating a type II-collagen tolerogenic peptide 査読有り

Hashizume F, Hino S, Kakehashi M, Okajima T , Nadano D, Aoki N, and Matsuda T

Transgenic Research 17 巻頁： 1117-1129 2008年

Glycoconjugate glycosyltransferases 招待有り査読有り

Furukawa K, Tsuchida A, Okajima T, Furukawa K

Glycoconj. J 26 巻頁： 987-98 2008年

Engineering of a mammalian O-glycosylation pathway in the yeast Saccharomyces cerevisiae: production of O-fucosylated epidermal growth factor domains 査読有り

Yuko Chigira, Takuji Oka, Tetsuya Okajima and Yoshifumi Jigami

Glycobiology 18 巻頁： 303-314 2008年

Association of chicken zona pellucida glycoprotein (ZP) B1 with ZPC induces formation of ZPB1-ZPC fibrous aggregates containing disulfide-bridged ZPB1 dimer. 査読有り

Okumura H, Okajima T, Nadano D, Matsuda T.

Biochem Biophys Res Commun. 364 巻 ( 3 ) 頁： 682-688 2007年12月

Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis. 査読有り

Miyoshi M, Okajima T, Matsuda T, Fukuda MN, Nadano D.

Biochem J 404 巻 ( 3 ) 頁： 373-381 2007年6月

Roles of fucosyltransferase and fucose in Notch signaling 招待有り

Okajima T, Matuda T.

Methods Enzymol 417 巻頁： 116-26 2006年

*Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding. 査読有り

Okajima T, Xu A, Lei L, Irvine KD.

Science 307 巻頁： 1599-603 2005年3月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Notch proteins are receptors for a conserved signaling pathway that affects numerous cell fate decisions. We found that in Drosophila, Protein O-fucosyltransferase 1 (OFUT1), an enzyme that glycosylates epidermal growth factor-like domains of Notch, also has a distinct Notch chaperone activity. OFUT1 is an endoplasmic reticulum protein, and its localization was essential for function in vivo. OFUT1 could bind to Notch, was required for the trafficking of wild-type Notch out of the endoplasmic reticulum, and could partially rescue defects in secretion and ligand binding associated with Notch point mutations. This ability of OFUT1 to facilitate folding of Notch did not require its fucosyltransferase activity. Thus, a glycosyltransferase can bind its substrate in the endoplasmic reticulum to facilitate normal folding.

*Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe. 招待有り査読有り

Okajima T, Xu A, Irvine KD.

J Biol Chem. 278 巻頁： 42340-5 2003年10月

Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. 査読有り

Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K.

J Biol Chem. 278 巻頁： 22787-94 2003年6月

XGalT-1 involved in the synthesis of glyosaminoglycans of proteoglycans and Ehlers-Danlos syndrome (progeroid type) 招待有り

Furukawa K, Okajima T, Nakamura Y.

Tanpakushitsu Kakusan Koso. 48 巻 ( 8 Suppl ) 頁： 1152-7 2003年1月

*Regulation of notch signaling by O-linked fucose. 招待有り査読有り

Okajima T, Irvine KD.

Cell 111 巻頁： 893-904 2002年12月

Galactosyltransferase I is a gene responsible for progeroid variant of Ehlers-Danlos syndrome: molecular cloning and identification of mutations. 招待有り

Furukawa K, Okajima T.

Biochim Biophys Acta. 1573 巻 ( 3 ) 頁： 377-81 2002年12月

Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis. 査読有り

Nakamura Y, Haines N, Chen J, Okajima T, Furukawa K, Urano T, Stanley P, Irvine KD, Furukawa K.

J Biol Chem. 277 巻 ( 48 ) 頁： 46280-8 2002年11月

b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. 査読有り

Okada M, Itoh Mi M, Haraguchi M, Okajima T, Inoue M, Oishi H, Matsuda Y, Iwamoto T, Kawano T, Fukumoto S, Miyazaki H, Furukawa K, Aizawa S, Furukawa K.

J Biol Chem. 277 巻 ( 3 ) 頁： 1633-6 2002年1月

Expression cloning of human globoside synthase cDNAs: Identification of β3Gal-T3 as UDP-N-acetylgalactosamine: globotriaosylceramide β1,3-N-acetyl-galactosaminyltransferase. 査読有り

Okajima T, Nakamura Y, Uchikawa M, Haslam DB, Numata Si, Furukawa K, Urano T, Furukawa K

J. Biol. Chem. 275 巻頁： 40498-40503 2000年

Molecular cloning and expression of mouse GD1α/GT1aα/GQ1bα synthase (ST6GalNAc VI) gene. 査読有り

Okajima T, Chen HH, Ito H, Kiso M, Tai T, Furukawa K, Urano T, Furukawa K.

J. Biol. Chem. 275 巻頁： 6717-6723 2000年

Molecular cloning of Gb3/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo-series glycosphingolipids. 査読有り

Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.

J. Biol. Chem. 275 巻頁： 15152-15156 2000年

Assignment of human xylosylprotein beta-1,4-galactosyltransferase gene (B4GALT7) to human chromosome 5q35.2-->q35.3 by in situ hybridization. 査読有り

Kuroiwa A, Matsuda Y, Okajima T, Furukawa K

Cytogenet. Cell Genet. 89 巻頁： 8-9 2000年

Molecular basis for the p phenotype: Identification of distinct and multiple mutations in the α1,4-galactosyltransferase gene in Swedish and Japanese individuals. 査読有り

Furukawa K, Iwamura K, Uchikawa M, Sojka BN, Wiels J, Okajima T, Urano T, Furukawa K.

J. Biol. Chem. 275 巻頁： 37752-37756 2000年

Molecular cloning of brain-specific GD1α synthase (ST6GalNAc V) containing CAG/Glutamine repeats. 査読有り

Okajima T, Fukumoto S, Ito H, Kiso M, Hirabayashi Y, Urano T, Furukawa K, Furukawa K.

J. Biol. Chem 274 巻頁： 30557-30562 1999年

Molecular cloning of a novel α2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. 査読有り

Okajima T, Fukumoto S, Miyazaki H, Ishida H, Kiso M, Furukawa K, Urano T, Furukawa K.

J. Biol. Chem. 274 巻頁： 11479-11486 1999年

Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans. 査読有り

Okajima T, Yoshida K, Kondo T, Furukawa K.

J. Biol. Chem. 274 巻頁： 22915-22918 1999年

*Molecular basis for the progeroid variant of Ehlers-Danlos syndrome. Identification and characterization of two mutations in galactosyltransferase I gene. 査読有り

Okajima T, Fukumoto S, Furukawa K, Urano T, Furukawa K.

J. Biol. Chem. 274 巻頁： 28841-28844 1999年

Nuclear localization of Ca2+/calmodulin-dependent protein kinase IV and calspermin. 査読有り

Okajima T, Okuno S, Fujisawa H, Hagiwara M.

Bioimages 4 巻頁： 117-128 1996年

RNA priming coupled with DNA synthesis on natural template by calf thymus DNA polymerase α-primase. 査読有り

Suzuki M, Savoysky E, Izuta S, Tatebe M, Okajima T, Yoshida S.

Biochemistry 32 巻頁： 12782-92 1993年

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<岡島 徹也>

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論文 - 岡島　徹也