Updated on 2025/06/23

写真a

 
OHTSUKA Hokuto
 
Organization
Graduate School of Pharmaceutical Sciences Department of Basic Medicinal Sciences Bioscience Assistant Professor
Graduate School
Graduate School of Pharmaceutical Sciences
Undergraduate School
School of Agricultural Sciences
Title
Assistant Professor
Contact information
メールアドレス
Homepage
http://www.ps.nagoya-u.ac.jp/lab_pages/microbio/aiba/index.html

Degree 1

  1. 博士（農学） （ 2011.4 ） 

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Research Areas 1

  1. Life Science / Applied microbiology  / molecular microbiology

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Current Research Project and SDGs 1

  1. 分裂酵母を用いた細胞寿命の研究

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Research History 3

  1. Nagoya University   Graduate School of Pharmaceutical Sciences Department of Basic Medicinal Sciences Bioscience   Assistant Professor

    2012.4

  2. Japan Society for Promotion of Science   Researcher

    2011.5 - 2012.3

  3. Japan Society for Promotion of Science   Researcher

    2009.4 - 2011.4

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Education 3

  1. Nagoya University   Graduate School of Bioagricultural Sciences

    2009.4 - 2011.4

  2. Nagoya University

    2007.4 - 2009.3

  3. Nagoya University

    2003.4 - 2007.3

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Papers 46

  1. Novel TORC1 inhibitor Ecl1 is regulated by phosphorylation in fission yeast Reviewed International journal Open Access

    Ohtsuka, H; Kawai, S; Ito, Y; Kato, Y; Shimasaki, T; Imada, K; Otsubo, Y; Yamashita, A; Mishiro-Sato, E; Kuwata, K; Aiba, H

    AGING CELL   Vol. 24 ( 4 ) page： e14450   2025.4

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/acel.14450

    Open Access

    Web of Science

    PubMed

  2. Characterization of P-type H<SUP>+</SUP>-ATPase Pma1 inhibitors that extend chronological lifespan in fission yeast Reviewed International journal

    Tamura, M; Yamashita, W; Hibi, T; Inui, S; Tanaka, K; Ozako, M; Shimasaki, T; Ohtsuka, H; Shibuya, M; Yamamoto, Y; Yokoshima, S; Aiba, H

    MOLECULAR GENETICS AND GENOMICS   Vol. 300 ( 1 ) page： 58   2025.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00438-025-02264-4

    Web of Science

    PubMed

  3. A novel transcription factor Sdr1 involving sulfur depletion response in fission yeast Reviewed International journal

    Ohtsuka, H; Ohara, K; Shimasaki, T; Hatta, Y; Maekawa, Y; Aiba, H

    GENES TO CELLS   Vol. 29 ( 8 ) page： 667 - 680   2024.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/gtc.13136

    Web of Science

    PubMed

  4. Low-Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, <i>Saccharomyces cerevisiae</i>, and <i>Schizosaccharomyces pombe</i> Reviewed International journal

    Ohtsuka, H; Shimasaki, T; Aiba, H

    ADVANCED BIOLOGY   Vol. 8 ( 5 ) page： e2400138   2024.5

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/adbi.202400138

    Web of Science

    PubMed

  5. Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes Reviewed International journal

    Kamada, Y; Umeda, C; Mukai, Y; Ohtsuka, H; Otsubo, Y; Yamashita, A; Kosugi, T

    JOURNAL OF CELL SCIENCE   Vol. 137 ( 4 )   2024.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1242/jcs.261625

    Web of Science

    PubMed

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Books 1

  1. 生物の寿命延長 　～老化・長寿命の基盤研究最前線～

    南野徹、笹子敬洋、植木浩二郎、荒谷紗絵、中西真、宇野雅晴、西田栄介、今岡進、宇留野晃、山本雅之、宮川拓也、田之倉優、須田将吉、石川正真、石川冬木、山本佑樹、高橋陵、宇田原栄俊、赤木一考、 佐々木貴史、新井康通、前澤善朗、越坂理也、加藤尚也、横手幸太郎、山本恒久、新村健、堀優太郎、小林武彦、坂本和一、菅原賢也、谷津智史、近藤嘉高、千葉卓哉、岩部美紀、岩部真人、山内敏正、堀川誠、水沼正樹、新谷知也、佐藤正資、清水重臣、大塚北斗、川口耕一郎、杉本昌隆、田口純平、山田泰広、脇田将裕、原英二、川上聖司、城村由和、田中久通、高橋暁子、 夜久圭介、中川崇、入江潤一郎、伊藤裕、狩野理延、中島良太、山名慶、城下郊平、田久保圭誉、山本伸一、大谷木正貴、安藝大輔、伊藤美菜子、吉村昭彦、齊藤貴志、内藤裕二、羽鳥恵、井藤喬夫、井垣達吏、勝海悟郎（ Role： Contributor ,  第7章　オートファジーと老化　第2節　オートファジーを誘導する栄養素と寿命制御（分裂酵母の寿命研究））

    (株)エヌ・ティー・エス  2022.3  （ ISBN:978-4-86043-773-2 ）

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    Total pages：460   Language：Japanese Book type：Textbook, survey, introduction

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Presentations 134

  1. A novel transcription factor Sdr1 involving sulfur depletion response in fission yeast

    2025.3.5 

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    Event date： 2025.3

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  2. Mechanism of Lifespan Extension by Aly2, an Arestin-like Protein in Fission Yeast

    2025.3.7 

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    Event date： 2025.3

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  3. Studies on endoplasmic reticulum stress and cell longevity in fission yeast

    2025.3.5 

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    Event date： 2025.3

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  4. Functional assignment and regulation of Ecl family genes in response to sulfur depletion in fission yeast.

    2025.3.5 

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    Event date： 2025.3

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  5. 分裂酵母の寿命制御因子Ecl1によるTORC1抑制機構の解析

    河井咲和, 大塚北斗, 伊藤由梨花, 大坪瑶子, 島崎嵩史, 山下朗, 饗場浩文

    第47回 日本分子生物学会年会  2024.11.28  日本分子生物学会

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    Event date： 2024.11

    Language：Japanese   Presentation type：Poster presentation  

    Venue：福岡  

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KAKENHI (Grants-in-Aid for Scientific Research) 5

  1. Analysis of the novel mTOR regulator Ecl protein - Aiming to regulate lifespan and fungal growth-

    Grant number：25K01930  2025.4 - 2029.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\18850000 （ Direct Cost: \14500000 、 Indirect Cost：\4350000 ）

  2. Analysis of cell miniaturization under sulfur depletion-Relationship between cyclin degradation and autophagy-

    Grant number：21K05363  2021.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

  3. Hidden response to amino acid depletion -Ecl1 family gene-dependent extension of lifespan-

    Grant number：19K15730  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Ohtsuka Hokuto

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    In the fission yeast Schizosaccharomyces pombe, amino acid starvation induces ecl1+, which regulates the chronological lifespan. Under amino acid starvation conditions, this induction contributes to adapt appropriately to starvation conditions, and avoid immediate death from hunger. We also found that the extension of chronological lifespan in starvation conditions is closely related to the suppression of the ribosome, which is an intracellular protein production plant. Some of the mechanisms for extending the lifespan of living organisms are conserved from the microorganism yeast to higher organisms, and it is becoming clear that starvation conditions are involved in extending the lifespan of higher organisms. It is expected that the microbial starvation response mechanism is the basis of the lifespan control mechanism of higher organisms.

  4. Analysis of mechanism of chronological lifespan extension by sulfur depletion in fission yeast

    Grant number：16K07662  2016.4 - 2020.3

    Ohtsuka Hokuto

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    Authorship：Principal investigator 

    Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

    Nutritional restrictions are known to increase the lifespan of various organisms. In this study, we found that sulfur restriction extended the chronological lifespan (CLS) of the fission yeast Schizosaccharomyces pombe. The sulfur restriction decreased cellular size, RNA content, and ribosomal proteins and increased sporulation rate. These cellular responses depended on Ecl1 family genes, the overexpression of which results in the extension of CLS. We also found that the Zip1 transcription factor results in the sulfur restriction-dependent expression of the ecl11 gene. We demonstrated that a decrease in ribosomal activity results in the extension of CLS in fission yeast. Therefore, we propose that sulfur restriction extends CLS through Ecl1 family genes in a ribosomal activity-dependent manner.

  5. Ecl1 familyタンパク質の寿命延長メカニズムの解析

    Grant number：26850048  2014.4 - 2017.3

    科学研究費補助金  若手研究(B)

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    Authorship：Principal investigator 

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Teaching Experience (On-campus) 108

  1. Basic Training for Crossover Research

    2024

  2. Specific Lecture for Advanced Pharmaceutical Sciences

    2024

  3. Seminar in Biological Science ⅠA

    2024

  4. Seminar in Biological Science ⅠB

    2024

  5. Biological Science Research Course

    2024

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Social Contribution 1

  1. 研究者・大学院生との懇談会

    Role(s)：Lecturer

    岐阜県立多治見北高等学校  2016

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