論文 - 塚本　眞幸

Synthesis and Characterization of Maleimide-Terminated Oligoimides Formed by a Michael Addition Reaction Using Methoxybenzenes 査読有り

T. Wakabayashi, S. Hor, K.-i. Oyama, and M. Tsukamoto

Tetrahedron   141 巻   頁： 133486   2023年5月

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.1016/j.tet.2023.133486

Real-Time Monitoring of Enzyme-Catalyzed Phosphoribosylation of Anti-Influenza Prodrug Favipiravir by Time-Lapse NMR Spectroscopy. 査読有り

T. Sugiki, A. Ito, Y. Hatanaka, M. Tsukamoto, T. Murata, K. Miyanishi, A. Kagawa, T. Fujiwara, M. Kitagawa, Y. Morita, and M. Negoro

NMR Biomed.   36 巻 ( 5 ) 頁： e4888   2022年12月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.1002/nbm.4888

Characterization of Organic Friction Modifiers Using Lateral Force Microscopy and Eyring Activation Energy Model. 査読有り

J. Hou, M. Tsukamoto, H. Zhang, K. Fukuzawa, S. Itoh, and N. Azuma

Tribol. Int.   178 巻 ( Part A ) 頁： 108052   2022年11月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.1016/j.triboint.2022.108052

Molecules with a TEMPO-Based Head Group as High-Performance Organic Friction Modifiers. 査読有り

J. Hou, M. Tsukamoto, S. Hor, X. Chen, J. Yang, H. Zhang, N. Koga, K. Yasuda, K. Fukuzawa, S. Itoh, and N. Azuma

Friction   11 巻 ( 2 ) 頁： 316 - 332   2022年5月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.1007/s40544-022-0610-0

Synthesis and characterization of methoxybenzene-linked polyimides formed by 1,4-addition to bismaleimides 査読有り

Seanghai Hor, Kin-ichi Oyama, Nobuaki Koga, and Masaki Tsukamoto

Polymer   238 巻   頁： 124326   2022年1月

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.1016/j.polymer.2021.124326

Metal Ions Sensing by Biodots Prepared from DNA, RNA, and Nucleotides

Wang Maofei, Tsukamoto Masaki, Sergeyev Vladimir G., Zinchenko Anatoly

Biosensors   11 巻 ( 9 )   2021年9月

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記述言語：日本語   出版者・発行元：Biosensors  

Nucleic acids that exhibit a high affinity toward noble and transition metal ions have attracted growing attention in the fields of metal ion sensing, toxic metal ion removal, and the construction of functional metal nanostructures. In this study, fluorescent nanoparticles (biodots) were synthesized from DNA, RNA, and RNA nucleotides (AMP, GMP, UMP, and CMP) using a hydrothermal (HT) method, in order to study their metal ion sensing characteristics. The fluorescent properties of biodots differ markedly between those prepared from purine and pyrimidine nucle-obases. All biodots demonstrate a high sensitivity to the presence of mercury cations (Hg2+ ), while biodots prepared from DNA, RNA, and guanosine monophosphate (GMP) are also sensitive to Ag+ and Cu2+ ions, but to a lesser extent. The obtained results show that biodots inherit the metal ion recognition properties of nucleobases, while the nucleobase composition of biodot precursors affects metal ion sensitivity and selectivity. A linear response of biodot fluorescence to Hg2+ concentration in solution was observed for AMP and GMP biodots in the range 0–250 µM, which can be used for the analytic detection of mercury ion concentration. A facile paper strip test was also developed that allows visual detection of mercury ions in solutions.

DOI： 10.3390/bios11090333

Web of Science

Scopus

PubMed

Fluorescent Nanoparticles Synthesized from DNA, RNA, and Nucleotides 査読有り

Wang Maofei, Tsukamoto Masaki, Sergeyev Vladimir G., Zinchenko Anatoly

Nanomaterials   11 巻 ( 9 )   2021年9月

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記述言語：日本語   出版者・発行元：Nanomaterials  

Ubiquitous on Earth DNA and other nucleic acids are being increasingly considered as promising biomass resources. Due to their unique chemical structure, which is different from that of a more common carbohydrate biomass polymers, materials based on nucleic acids may exhibit new attractive characteristics. In this study, fluorescent nanoparticles (biodots) were prepared by a hydrothermal (HT) method from various nucleic acids (DNA, RNA, nucleotides, and nucleosides) to establish the relationship between the structure of precursors and fluorescent properties of biodots and to optimize conditions for preparation of the most fluorescent product. HT treatment of nucleic acids results in decomposition of sugar moieties and depurination/depyrimidation of nucleobases, while their consequent condensation and polymerization gives fluorescent nanoparticles. Fluorescent properties of DNA and RNA biodots are drastically different from biodots synthesized from individual nucleotides. In particular, biodots synthesized from purine-containing nucleotides or nucleosides show up to 50-fold higher fluorescence compared to analogous pyrimidine-derived biodots. The polymeric nature of a precursor disfavors formation of a bright fluorescent product. The reported effect of the structure of the nucleic acid precursor on the fluorescence properties of biodots should help designing and synthesizing brighter fluorescent nanomaterials with broader specification for bioimaging, sensing, and other applications.

DOI： 10.3390/nano11092265

Web of Science

Scopus

PubMed

Brønsted acid-catalyzed 1,4-addition of 1,3,5-trimethoxybenzene to maleimides and acrylates 査読有り

Seanghai Hor, Kin-ichi Oyama, Nobuaki Koga, and Masaki Tsukamoto

Tetrahedron Lett.   74 巻   頁： Article 153100   2021年6月

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担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.tetlet.2021.153100

Experimental Study of Application of Molecules with a Cyclic Head Group Containing a Free Radical as Organic Friction Modifiers 査読有り

X. Zhang, M. Tsukamoto, H. Zhang, Y. Mitsuya, S. Itoh, and K. Fukuzawa

J. Adv. Mech. Des. Syst.   14 巻 ( 4 ) 頁： JAMDSM0044   2020年4月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1299/jamdsm.2020jamdsm0044

Recent Application of Acidic 1,3-Azolium Salts as Promoters in the Solution-Phase Synthesis of Nucleosides and Nucleotides 招待有り 査読有り

M. Tsukamoto and K.-i. Oyama

Tetrahedron Lett.     頁： 2477-2484   2018年6月

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記述言語：英語  

DOI： 10.1016/j.tetlet.2018.03.074

A Solid-Supported Acidic Oxazolium Perchlorate as an Easy-Handling Catalyst for the Synthesis of Modified Pyrimidine Nucleosides via Vorbrüggen-type N-Glycosylation 査読有り

N. Basu, K.-i. Oyama, and M. Tsukamoto

Tetrahedron Lett.   58 巻 ( 20 ) 頁： 1921–1924   2017年5月

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.tetlet.2017.03.046

Synthesis of Ribonucleoside 3',5'-Cyclic Monophosphorodithioates 査読有り

A. Fukuhara and M. Tsukamoto

Tetrahedron   71 巻 ( 23 ) 頁： 3878-3884   2015年6月

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.tet.2015.04.024

Practical Synthesis of Adenosine 3',5'-Cyclic Monophosphorodithioate 査読有り

A. Fukuhara, H. Morita, K.-i. Oyama, and M. Tsukamoto

Tetrahedron Lett.   55 巻 ( 38 ) 頁： 5261-5263   2014年9月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.tetlet.2014.07.117

Synthesis of Modified Pyrimidine Nucleosides via Vorbrüggen-type N-Glycosylation Catalyzed by 2-Methyl-5-phenylbenzoxazolium Perchlorate 査読有り

H. Shirouzu, H. Morita, and M. Tsukamoto

Tetrahedron   70 巻 ( 22 ) 頁： 3635-3639   2014年3月

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.tet.2014.03.013

Cyclic Bis(3'-5')diadenylic Acid (c-di-AMP) Analogs Promote the Activities of Photosynthesis and Respiration of Chlamydomonas reinhardtii 査読有り

T. Tezuka, H. Shirouzu, K. Ishida, N. Suzuki, T. Matsuo, K.-i. Oyama, S. Aoki, and M. Tsukamoto

Am. J. Plant Sciences   5 巻 ( 1 ) 頁： 24-28   2014年1月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.4236/ajps.2014.51004

Synthesis of 2'-Modified Cyclic Bis(3'-5')diadenylic Acids (c-di-AMPs) and Their Promotion of Cell Division in a Freshwater Green Alga 査読有り

T. Tezuka, N. Suzuki, K. Ishida, K.-i. Oyama, S. Aoki, and M. Tsukamoto

Chem. Lett.   41 巻 ( 12 ) 頁： 1723-1725   2012年12月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： doi:10.1246/cl.2012.1723

Controlling Glycosyl Bond Conformation of Guanine Nucleosides: Stabilization of the anti Conformer in 5'-O-Ethylguanosine 査読有り

H. Asami, S.-h. Urashima, M. Tsukamoto, A. Motoda, Y. Hayakawa, and H. Saigusa

J. Phys. Chem. Lett.   3 巻   頁： 571–575   2012年2月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1021/jz300081e

Practical Synthesis of Cyclic Bis(3'-5') diadenylic Acid (c-di-AMP) 査読有り

N. Suzuki, K.-i. Oyama, and M. Tsukamoto

Chem. Lett.   40 巻 ( 10 ) 頁： 1113-1114   2011年9月

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： doi:10.1246/cl.2011.1113

Gas-Phase Isolation of Diethyl Guanosine 5'-Monophosphate and Its Conformational Assignment 査読有り

H. Asami, M. Tsukamoto, Y. Hayakawa, and H. Saigusa

Phys. Chem. Chem. Phys.   12 巻 ( 42 ) 頁： 13918-13921   2010年11月

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1039/C0CP01105C

Equilibrium of Homochiral Oligomerization of a Mixture of Enantiomers. Its Relevance to Nonlinear Effects in Asymmetric Catalysis 査読有り

M. Tsukamoto, K. Gopalaiah, and H. B. Kagan

J. Phy. Chem. B   112 巻 ( 48 ) 頁： 15361-15368   2008年12月

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記述言語：英語   掲載種別：研究論文（学術雑誌）