論文 - 澤田 誠
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Calmodulin as a Key Regulator of Exosomal Signal Peptides 査読有り
Ono Kenji, Niwa Mikio, Suzuki Hiromi, Kobayashi Nahoko Bailey, Yoshida Tetsuhiko, Sawada Makoto
CELLS 12 巻 ( 1 ) 頁: 158 2023年1月
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Signal Sequence-Dependent Orientation of Signal Peptide Fragments to Exosomes 査読有り 国際誌
Ono Kenji, Niwa Mikio, Suzuki Hiromi, Kobayashi Nahoko Bailey, Yoshida Tetsuhiko, Sawada Makoto
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 巻 ( 6 ) 2022年3月
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ミクログリアと情動制御 招待有り 査読有り
生体の科学[増大特集:脳とからだ 2021年10月
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Detection of Alzheimer's disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein 査読有り 国際共著
Ji Bin, Ono Maiko, Yamasaki Tomoteru, Fujinaga Masayuki, Zhang Ming-Rong, Seki Chie, Aoki Ichio, Kito Seiji, Sawada Makoto, Suhara Tetsuya, Sahara Naruhiko, Higuchi Makoto
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 41 巻 ( 8 ) 頁: 2076 - 2089 2021年8月
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Secretion of signal peptides via extracellular vesicles 査読有り
Ono Kenji, Niwa Mikio, Suzuki Hiromi, Kobayashi Nahoko Bailey, Yoshida Tetsuhiko, Sawada Makoto
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 560 巻 頁: 21 - 26 2021年6月
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Silica Nanoparticle Induced Lung Injury in Mice: Dissecting Relative Contribution of Its Size and Surface Modification 査読有り
Inoue M., Sakamoto K., Suzuki A., Nakahara Y., Hashimoto N., Hasegawa Y., Sawada M.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 201 巻 2020年
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LC-MS/MS imaging with thermal film-based laser microdissection 査読有り
Oya Michiko, Suzuki Hiromi, Anas Andrea Roxanne J., Oishi Koichi, Ono Kenji, Yamaguchi Shun, Eguchi Megumi, Sawada Makoto
ANALYTICAL AND BIOANALYTICAL CHEMISTRY 410 巻 ( 2 ) 頁: 491 - 499 2018年1月
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The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model 査読有り
Yoshioka Naoki, Tanaka Miyako, Ochi Kozue, Watanabe Akiko, Ono Kenji, Sawada Makoto, Ogi Tomoo, Itoh Michiko, Ito Ayaka, Shiraki Yukihiro, Enomoto Atsushi, Ishigami Masatoshi, Fujishiro Mitsuhiro, Ogawa Yoshihiro, Suganami Takayoshi
BIOMEDICINE & PHARMACOTHERAPY 140 巻 頁: 111738 2021年8月
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Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophages 査読有り
Inoue Masahide, Sakamoto Koji, Suzuki Atsushi, Nakai Shinya, Ando Akira, Shiraki Yukihiko, Nakahara Yoshio, Omura Mika, Enomoto Atsushi, Nakase Ikuhiko, Sawada Makoto, Hashimoto Naozumi
PARTICLE AND FIBRE TOXICOLOGY 18 巻 ( 1 ) 頁: 21 2021年6月
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Peripheral benzodiazepine receptor/18 kDa translocator protein positron emission tomography imaging in a rat model of acute brain injury 査読有り 国際共著
Nomura Masahiko, Toyama Hiroshi, Suzuki Hiromi, Yamada Takashi, Hatano Kentaro, Wilson Alan A., Ito Kengo, Sawada Makoto
ANNALS OF NUCLEAR MEDICINE 35 巻 ( 1 ) 頁: 8 - 16 2021年1月
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Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin 査読有り 国際共著 国際誌
Wang Liyan, Li Mengjie, Lin Yinzhi, Du Shuwen, Liu Zhenyu, Ju Jianhua, Suzuki Hiromi, Sawada Makoto, Umezawa Kazuo
JOURNAL OF ANTIBIOTICS 73 巻 ( 9 ) 頁: 622 - 629 2020年9月
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Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects 査読有り
Kawakubo Mitsuhiro, Tanaka Miyako, Ochi Kozue, Watanabe Akiko, Saka-Tanaka Marie, Kanamori Yohei, Yoshioka Naoki, Yamashita Satoko, Goto Moritaka, Itoh Michiko, Shirakawa Ibuki, Kanai Sayaka, Suzuki Hiromi, Sawada Makoto, Ito Ayaka, Ishigami Masatoshi, Fujishiro Mitsuhiro, Arima Hiroshi, Ogawa Yoshihiro, Suganami Takayoshi
SCIENTIFIC REPORTS 10 巻 ( 1 ) 頁: 983 2020年1月
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Novel Oxindole-Curcumin Hybrid Compound for Antioxidative Stress and Neuroprotection 査読有り
Hirata Yoko, Ito Yuki, Takashima Madoka, Yagyu Kazuya, Oh-hashi Kentaro, Suzuki Hiromi, Ono Kenji, Furuta Kyoji, Sawada Makoto
ACS CHEMICAL NEUROSCIENCE 11 巻 ( 1 ) 頁: 76 - 85 2020年1月
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Role of Microglia in Neuroinflammation
Suzuki Hiromi, Sawada Makoto
PET/CT FOR INFLAMMATORY DISEASES: BASIC SCIENCES, TYPICAL CASES, AND REVIEW 頁: 30 - 34 2020年
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A peptide based on transmembrane domain of S1PR4 as a tumor cell growth inhibitor
Yoshida Tetsuhiko, Tanaka Kenichi, Asakawa Shuichi, Sawada Makoto, Hasegawa Yoshinori, Nakase Ikuhiko, Kobayashi Nahoko Bailey
MOLECULAR CANCER THERAPEUTICS 18 巻 ( 12 ) 2019年12月
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Anti-Claudin Antibodies as a Concept for Development of Claudin-Directed Drugs
Hashimoto Yosuke, Okada Yoshiaki, Shirakura Keisuke, Tachibana Keisuke, Sawada Makoto, Yagi Kiyohito, Doi Takefumi, Kondoh Masuo
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 368 巻 ( 2 ) 頁: 179 - 186 2019年2月
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Selective autophagy eliminates ALS-related mutant SOD1 protein in cultured microglia
Niida Motoko Kawaguchi, Tsukahara Fujiko, Sudou Norihiro, Yamamoto Tomoko, Sawada Makoto, Watabe Kazuhiko, Shibata Noriyuki
BRAIN PATHOLOGY 29 巻 頁: 94 - 95 2019年2月
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A peptide based on transmembrane domain of S1PR1 as a tumor cell growth inhibitor
Kobayashi N. Bailey, Sawada M., Hasegawa Y., Yoshida T.
EUROPEAN JOURNAL OF CANCER 103 巻 頁: E94 - E94 2018年11月
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Novel oxindole derivatives prevent oxidative stress-induced cell death in mouse hippocampal HT22 cells
Hirata Yoko, Yamada Chika, Ito Yuki, Yamamoto Shotaro, Nagase Haruna, Oh-hashi Kentaro, Kiuchi Kazutoshi, Suzuki Hiromi, Sawada Makoto, Furuta Kyoji
NEUROPHARMACOLOGY 135 巻 頁: 242 - 252 2018年6月
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Inducible nitric oxide synthase during the late phase of sepsis is associated with hypothermia and immune cell migration.
Takatani Y, Ono K, Suzuki H, Inaba M, Sawada M, Matsuda N
Laboratory investigation; a journal of technical methods and pathology 98 巻 ( 5 ) 頁: 629 - 639 2018年5月
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Visualization of Arc promoter-driven neuronal activity by magnetic resonance imaging
Wu Qi, Ono Kenji, Suzuki Hiromi, Eguchi Megumi, Yamaguchi Shun, Sawada Makoto
NEUROSCIENCE LETTERS 666 巻 頁: 92-97 2018年2月
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Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis
Lin Hsiaoyun, Muramatsu Rieko, Maedera Noriko, Tsunematsu Hiroto, Hamaguchi Machika, Koyama Yoshihisa, Kuroda Mariko, Ono Kenji, Sawada Makoto, Yamashita Toshihide
EBIOMEDICINE 27 巻 頁: 71-85 2018年1月
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Optogenetic control of cell differentiation in channelrhodopsin-2-expressing OS3, a bipotential glial progenitor cell line
Ono K, Suzuki H, Yamamoto R, Sahashi H, Takido Y, Sawada M
Neurochemistry International 104 巻 頁: 49-63 2017年3月
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The novel monoclonal antibody 9F5 reveals expression of a fragment of GPNMB/osteoactivin processed by furin-like protease(s) in a subpopulation of microglia in neonatal rat brain
Kawahara K, Hirata H, Ohbuchi K, Nishi K, Maeda A, Kuniyasu A, Yamada D, Maeda T, Tsuji A, Sawada M, Nakayama H
64 巻 ( 11 ) 頁: 1938-1961 2016年11月
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Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages
Matsumoto T,Takahashi N, Kojima T, Yoshioka Y, Ishikawa J, Furukawa K, Ono K, Sawada M, Ishiguro N,Yamamoto A
Arthritis research & therapy 18 巻 ( 1 ) 頁: 133 2016年6月
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Nanoparticles speckled by ready-to-conjugate lanthanide complexes for multimodal imaging
Biju V, Hamada M, Ono K, Sugino S, Ohnishi T, Shibu ES, Yamamura S, Sawada M, Nakanishi S, Shigeri Y, Wakida SI.
Nanoscale 7 巻 ( 36 ) 頁: 14829-14837 2015年9月
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Insular neural system controls decision-making in healthy and methamphetamine-treated rats
Mizoguchi H, Katahira K, Inutsuka A, Fukumoto K, Nakamura A, Wang T, Nagai T, Sato J, Sawada M, Ohira H, Yamanaka A, Yamada K
Proceedings of the National Academy of Sciences of the United States of America 112 巻 ( 29 ) 頁: E3930-3939 2015年7月
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Rapid trimming of cell surface polySia by exovesicular sialidase triggers release of preexisting surface neurotrophin
Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OM, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K, Sato C.
The Journal of Biological Chemistry 290 巻 ( 21 ) 頁: 13202-13214 2015年5月
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Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [ 11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [ 11C](R)-PK11195.
Hatano K, Sekimata K, Yamada T, Abe J, Ito K, Ogawa M, Magata Y, Toyohara J, Ishiwata K, Biggio G, Serra M, Laquintana V, Denora N, Latrofa A, Trapani G, Liso G, Suzuki H, Sawada M, Nomura M, Toyama H.
Ann Nucl Med 29 巻 ( 4 ) 頁: 325-335 2015年5月
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Nanoparticles speckled by ready-to-conjugate lanthanide complexes for multimodal imaging
Biju V, Hamada M, Ono K, Sugino S, Ohnishi T, Shibu ES, Yamamura S, Sawada M, Nakanishi S, Shigeri Y, Wakida SI.
Nanoscale 頁: in press 2015年
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Insular neural system controls decision-making in healthy and methamphetamine-treated rats
Mizoguchi H, Katahira K, Inutsuka A, Fukumoto K, Nakamura A, Wang T, Nagai T, Sato J, Sawada M, Ohira H, Yamanaka A, Yamada K
Proc. Natl. Acad. Sci. U.S.A 頁: in press 2015年
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Novel positively charged nanoparticle labeling for in vivo imaging of adipose tissue-derived stem cells
YUKAWA H, NAKAGAWA S, YOSHIZUMI Y, WATANABE M, SAITO H, MIYAMOTO Y, NOGUCHI H, OISHI K, ONO K, SAWADA M, KATO I, ONOSHIMA D, OBAYASHI M, HAYASHI Y, KAJI N, ISHIKAWA T, HAYASHI S, BABA Y
PLoS One 9 巻 ( 11 ) 頁: e110142 2014年11月
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Protective effect of INI-0602, a gap junction inhibitor, on dopaminergic neurodegeneration of mice with unilateral 6-hydroxydopamine injection
SUZUKI Hiromi, ONO Kenji, SAWADA Makoto
Journal of nueral Transmission 121 巻 ( 11 ) 頁: 1349-1355 2014年11月
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Glutamate release from astrocyte cell-line GL261 via alterations in the intracellular ion environment 査読有り
ONO K, SUZUKI H, HIGA M, TABATA K, SAWADA M
Journal of Neural Transmission 121 巻 ( 3 ) 頁: 245-257 2014年3月
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Increases in intracellular pH facilitate endocytosis and decrease availability of voltage-gated proton channels in osteoclasts and microglia 査読有り
Sakai H, Li G, Hino Y, Moriura Y, Kawawaki J, Sawada M, Kuno M.
The Journal of Physiology 591 巻 ( Pt23 ) 頁: 5851-5866 2013年12月
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The effect of lipid emulsion on intracellular bupivacaine as a mechanism of lipid resuscitation: an electrophysiological study using voltage-gated proton channels 査読有り
HORI Kotaro, MATSUURA Tadashi, MORI Takashi, KUNO Miyuki, SAWADA Makoto, NISHIKAWA Kiyonobu
Anesthesia and analgesia 117 巻 ( 6 ) 頁: 1293-1301 2013年12月
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Photouncaging nanoparticles for MRI and fluorescence imaging in vitro and in vivo 査読有り
SHIBU Edakkattuparambil Sidharth, ONO Kenji, SUGINO Sakiko, NISHIOKA Ayami, YASUDA Akikazu, SHIGERI Yasushi, WAKIDA Shin-ichi, SAWADA Makoto, BIJU Vasudevanpillai
American Chemical Society nano 7 巻 ( 11 ) 頁: 9851-9859 2013年11月
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Singlet-Oxygen-Sensitizing Near-Infrared-Fluorescent Multimodal Nanoparticles 査読有り
Shibu ES, Sugino S, Ono K, Saito H, Nishioka A, Yamamura S, Sawada M, Nosaka Y, Biju V
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52 巻 ( 40 ) 頁: 10559-10563 2013年9月
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In vivo imaging of transplanted islets labeled with a novel cationic nanoparticle 査読有り
OISHI Koichi, MIYAMOTO Yoshitaka, SAITO Hiroaki, MURASE Katsutoshi, ONO Kenji, SAWADA Makoto, WATANABE Masami, NOGUCHI Yasufumi, FUJIWARA Toshiyoshi, HAYASHI Shuji, NOGUCHI Hirofumi.
PLoS one 8 巻 ( 2 ) 頁: e57046 2013年2月
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Novel positive-charged nanoparticles for efficient magnetic resonance imaging of islet transplantation.
OISHI Kouichi, NOGUCHI Hirofumi, SAITO Hiroaki,YUKAWA H, MIYAMOTO Yoshitaka, ONO Kenji, MURASE Katsutoshi, SAWADA Makoto, HAYASHI Shuji
Cell Medicine 3 巻 ( 1-3 ) 頁: 43-49 2012年10月
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Inhibition of voltage-gated proton channels by local anaesthetics in GMI-R1 rat microglia 査読有り
Matsuura T, Mori T, Hasaka M, Kuno M, Kawawaki J, Nishikawa K, Narahashi T, Sawada M, Asada A
The Journal of Physiology 590 巻 ( Pt4 ) 頁: 827-844 2012年2月
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Hemokinin-1 gene expression is upregulated in microglia activated by lipopolysaccharide through NFkB and p38 MAPK signaling pathways
SAKAI Atsushi, TAKASU Kumiko, SAWADA Makoto, SUZUKI Hidenori
PLoS one 7 巻 ( 2 ) 頁: e32268 2012年2月
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New fluorescent probes targeting the mitochondrial-located translocator protein 18 kDa (TSPO) as activated microglia imaging agents. 査読有り
DENORA N, LAQUINTANA V, TRAPANI A, SUZUKI H, SAWADA M, TRAPANI G
Pharmaceutical Research 28 巻 ( 11 ) 頁: 2820-2382 2011年11月
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Alzheimer's disease and microglia
HIGUCHI M, JI B, MAEDA J, MARUYAMA M, ONO M, SAWADA M, SUHARA T
Rinsho Shinkeigaku 51 巻 ( 11 ) 頁: 1031 2011年11月
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Effects of a Brain-Engraftable Microglial Cell Line Expressing Anti-Prion scFv Antibodies on Survival Times of Mice Infected with Scrapie Prions 査読有り
FUJITA K, YAMAGUCHI Y, MORI T, MURAMATSU N, MIYAMOTO T, YANO M, MIYATA H, OOTSUYAMA A, SAWADA M, MATSUDA H, KAJI R, SAKAGUCHI S
Cellular and Molecular neurobioloy 31 巻 ( 7 ) 頁: 999-1008 2011年10月
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Matrix Metalloproteinase-9 Contributes to Kindled Seizure Development in Pentylenetetrazole-Treated Mice by Converting Pro-BDNF to Mature BDNF in the Hippocampus. 査読有り
MIZOGUCHI H, NAKADE J, TACHIBANA M, IBI D, SOMEYA E, KOIKE H, KAMEI H, NABESHIMA T, ITOHARA S, TAKUMA K, SAWADA M, SATO J, YAMADA K
Journal of Neuroscience 31 巻 ( 36 ) 頁: 12963-12971 2011年9月
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4-hydroxy-2-nonenal upregulates and phosphorylates cytosolic phospholipase A (2) in cultured Ra2 microglial cells via MAPK pathways 査読有り
SHIBATA N, KATO Y, INOSE Y, HIROI A, YAMAMOTO T, MORIKAWA S, SAWADA M, KOBAYASHI M
Neuropathology 31 巻 ( 2 ) 頁: 122-128 2011年4月
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Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome. 査読有り
IWAMA S, SUGIMURA Y, SUZUKI H, SUZUKI H, MURASE T, OZAKI N, NAGASAKI H, ARIMA H, MURATA Y, SAWADA M, OISO Y
Glia 59 巻 ( 3 ) 頁: 452-462 2011年3月
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Effects of a Brain-Engraftable Microglial Cell Line Expressing Anti-Prion scFv Antibodies on Survival Times of Mice Infected with Scrapie Prions 査読有り
FUJITA K, YAMAGUCHI Y, MORI T, MURAMATSU N, MIYAMOTO T, YANO M, MIYATA H, OOTSUYAMA A, SAWADA M, MATSUDA H, KAJI R, SAKAGUCHI S
Cellular and Molecular neurobioloy 頁: in press 2011年
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Electrosprayed Synthesis of Red-Blood-Cell-Like Particles with Dual Modality for Magnetic Resonance and Fluorescence Imaging. 査読有り
HAYASHI K, ONO K, SUZUKI H, SAWADA M, MORIYA M, SAKAMOTO W, YOGO T
Small 6 巻 ( 21 ) 頁: 2384-2391 2010年11月
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High-frequency, magnetic-field-responsive drug release from magnetic nanoparticle/organic hybrid based on hyperthermic effect.
HAYASHI K, ONO K, SUZUKI H, SAWADA M, MORIYA M, SAKAMOTO W, YOGO T
ACS applied materials & interfaces 2 巻 ( 7 ) 頁: 1903-1911 2010年7月
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One-pot biofunctionalization of magnetic nanoparticles via thiol-ene click reaction for magnetic hyperthermia and magnetic resonance imaging 査読有り
HAYASHI K, ONO K, SUZUKI H, SAWADA M, MORIYA M, SAKAMOTO W, YOGO T
Chemistry of Materials 22 巻 ( 12 ) 頁: 3768-3772 2010年6月
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Quantum dots labeling using octa-arginine peptides for imaging of adipose tissue-derived stem cells. 査読有り
Yukawa H, Kagami Y, Watanabe M, Oishi K, Miyamoto Y, Okamoto Y, Tokeshi M, Kaji N, Noguchi H, Ono K, Sawada M, Baba Y, Hamajima N, Hayashi S.
Biomaterials 31 巻 ( 14 ) 頁: 4094-4103 2010年5月
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Two activated stages of microglia and PET imaging of peripheral benzodiazepine receptors with [(11)C]PK11195 in rats 査読有り
ITO Fumitaka, TOYAMA Hiroshi, KUDO Gen, SUZUKI Hiromi, HATANO Kentaro, ICHISE Masanori, KATADA Kazujhiro, ITO Kengo, SAWADA Makoto
Annals of Nuclear Medecine 24 巻 ( 3 ) 頁: 163-169 2010年4月
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Delayed neural damage is induced by iNOS-expressing microglia in a brain injury model. 査読有り
ONO K, SUZUKI H, SAWADA M
Neuroscience Letters 473 巻 ( 2 ) 頁: 146-150 2010年4月
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Neuroprotective and Neurotoxic Phenotypes of Activated Microglia in Neonatal Mice with Respective MPTP- and Ethanol-Induced Brain Injury. 査読有り
Sawada H, Suzuki H, Nagatsu T, Sawada M.
Neuro-degenerative Diseases 7 巻 ( 1-3 ) 頁: 64-67 2010年2月
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4-hydroxy-2-nonenal upregulates and phosphorylates cytosolic phospholipase A (2) in cultured Ra2 microglial cells via MAPK pathways 査読有り
SHIBATA N, KATO Y, INOSE Y, HIROI A, YAMAMOTO T, MORIKAWA S, SAWADA M, KOBAYASHI M
Neuropathology in press 巻 2010年
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Minocycline prevents osmotic demyelination syndrome by inhibiting the activation of microglia. 査読有り
SUZUKI H, SUGIMURA Y, IWAMA S, SUZUKI H, OZAKI N, NAGASAKI H, ARIMA H, SAWADA M, OISO Y.
Journal of the American Society of Nephrology 21 巻 ( 12 ) 頁: 2090-2098 2010年
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*Ferritin reporter used for gene expression imaging by magnetic resonance. 査読有り
ONO Kenji, FUMA Kazuya, TABATA Kaori, SAWADA Makoto
Biochemical and Biophysical Research Communications 388 巻 ( 3 ) 頁: 589-594 2009年10月
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Temperature dependence of proton permeation through a voltage-gated proton channel 査読有り
KUNO Miyuki, ANDO Hiroyuki , MORIHATA Hirokazu, SAKAI Hiromu, MORI Hiroyuki, SAWADA Makoto, OIKI Shigetoshi
The Journal of General Physiology 134 巻 ( 3 ) 頁: 191-205 2009年9月
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Interleukin-6 induces prostaglandin E2 synthesis in mouse astrocytes 査読有り
CHIKUMA T, YOSHIMOTO T, OHBA M, SAWADA M, KATO T, SAKAMOTO T, HIYAMA Y, HOJO H
Journal of Molecilar Neuroscience 39 巻 ( 1-2 ) 頁: 175-184 2009年9月
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Marked induction of inducible nitric oxide synthase and tumor necrosis factor-alpha in rat CD40(+) microglia by comparison to CD40(-) microglia.
KAWAHARA K, YOSHIDA A, KOGA K, YOKOO S,KUNIYASU A, GOTOH T, SAWADA M, NAKAYAMA H
Journal of Neuroimmunology 208 巻 ( 1-2 ) 頁: 70-79 2009年3月
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Transforming growth factor-beta 1 upregulates keratan sulfate and chondroitin sulfate biosynthesis in microglias after brain injury 査読有り
YIN Jiarong, SAKAMOTO Kazuma, ZHANG Haoqian, ITO Zenya, IMAGAMA Shiro, KISHIDA Satoshi, NATORI Takamitsu, SAWADA Makoto, MATSUYAMA Yukihiro, KADOMATSU Kenji
Brain Research 1263 巻 頁: 10-22 2009年3月
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Neuroprotective and toxic changes in microglia in neurodegenerative disease 査読有り
SAWADA Makoto
Parkinsonism & Related Disorders 15 巻 頁: S39-S41 2009年1月
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L-dopa therapy for Parkinson's disease: Past, present, and future 査読有り
NAGATSU T, SAWADA M
Parkinsonism & Related Disorders 15 巻 頁: S3-S8 2009年1月
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A link between stress and depression: Shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression 査読有り
MIURA H, OZAKI N, SAWADA M, ISOBE K, OHTA T, NAGATSU T
Stress-The International Journal on the Biology of Stress) 12 巻 ( 5 ) 頁: 198-209 2009年
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Increase in hemokinin-1 mRNA in the spinal cord during the early phase of a neuropathic pain state 査読有り
MATSUMURA T, SAKAI A, NAGANO M, SAWADA M, SUZUKI H, UMINO M, SUZUKI H
Brit J Pharmacol 155 巻 ( 5 ) 頁: 767-774 2008年11月
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Blockade of microglial glutamate release protects against ischemic brain injury 査読有り
TAKEUCHI H,SHIJIE J, SUZUKI H, DOI Y, J. Liang, KAWANOKUCHI J, MIZUNO T, SAWADA M, SUZUMUTRA A
Exp Neurol 214 巻 ( 1 ) 頁: 144-146 2008年11月
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*Imaging of Peripheral Benzodiazepine Receptor Expression as Biomarkers of Detrimental versus Beneficial Glial Responses in Mouse Models of Alzheimer's and Other CNS Pathologies. 査読有り
Ji B, MAEDA J, SAWADA M, ONO M, OKAUCHI T, INAJI M, Zhang MR, SUZUKI K, ANDO K, Staufenbiel M, Trojanowski JQ, Lee VM, HIGUCHI M, SUHARA T
J Neurosci 28 巻 ( 47 ) 頁: 12255-12267 2008年11月
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Interleukin-4induced Selective Clearance of Oligomeric b-Amyloid peptide by Rat Primary Type-2 Microglia 査読有り
SHIMIZU E, KAWAHARA K , KAJIZONO M, SAWADA M, NAKAYAMA H
J Immunol 181 巻 ( 9 ) 頁: 6503-6513 2008年11月
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In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand: [(11)C]PK-11195 and animal PET following ethanol injury in rat striatum 査読有り
TOYAMA H, HATANO K, SUZUKI H, ICHISE M, MOMOSAKI S, KUDO G, ITO F, KATO T, YAMAGUCHI H, KATADA K, SAWADA M, ITO K
Ann Nucl Med 22 巻 ( 5 ) 頁: 417-424 2008年6月
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A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression. 査読有り
MIURA H, OZAKI N, SAWADA M, ISOBE K, OHTA T, NAGATSU T
Stress-The International Journal on the Biology of Stress 11 巻 ( 3 ) 頁: 198-209 2008年5月
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Effects of aging on neuroprotective and neurotoxic properties of microglia in neurodegenerative diseases. 査読有り
SAWADA Makoto, SAWADA Hirohide, NAGATSU Toshiharu
Neurodegener Dis 5 巻 ( 3-4 ) 頁: 254-256 2008年3月
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Stimulus dependent regulation of the phagocyte NADPH oxidase by a VAV1, rac 1, and PAK1 signaling axis. 査読有り
ROEPSTORFF Kirstine, RASMUSSEN Izabela, SAWADA Makoto, CUDRE-MAROUX Cristophe, SALOMON Patrick, BOKOCH Gary, VAN DEURS Bo, VIHARDT Frederik
J Biol Chem 283 巻 ( 12 ) 頁: 7983-7993 2008年3月
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Early and late activation of the voltage-gated proton channel during lactic acidosis through pH-dependent and -independent mechanisms 査読有り
MORIHATA Hirokazu, KAWAWAKI Junko, OKINA Masako, SAKAI Hiromu, NOTOMI Takuya, SAWADA Makoto, KUNO Miyuki
Pflugers Arch 455 巻 ( 5 ) 頁: 829-838 2008年2月
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N-Benzyl-2-(6,8-dichloro-2-(-(4-chlorophenyl)imidazo[1,2-alpyridin-3-yl)-N-(6-(7-nitrobenzo[c][1,2,5]oxadiazol-4-ylamino) hexyl)acetamide as a New Fluorescent Probe for Peripheral Benzodiazepine Receptor and Microglial Cell Visualization. 査読有り
LAQUINTANA Valentino, DENORA Nunzio, LOPEDOTA Angela, SUZUKI Hiromi, SAWADA Makoto, SERRA Mariangela, BIGGIO Giovanni, LATROFA Andrea, TRAPANI Giuseppe, LISO Gaetano
Bioconjug Chem 18 巻 ( 5 ) 頁: 1397-1407 2007年9月
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Antidepressants inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide 査読有り
Hashioka, S., Klegeris, A., Monji, A., Kato, T., Sawada, M., McGeer, P.L. and Kanba, S.
206 巻 ( 0 ) 頁: 33-42 2007年7月
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Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Sawada, H., Hishida, R., Hirata, Y., Ono, K., Suzuki, H., Muramatsu, S., Nakano, I., Nagatsu, T. and Sawada, M.
J Neurosci Res 85 巻 ( 8 ) 頁: 1752-1761 2007年6月
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Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway 査読有り
Ito, S., Kimura, K., Haneda, M., Ishida, Y., Sawada, M. and Isobe, K.
42 巻 ( 6 ) 頁: 532-537 2007年6月
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The effects of general anesthetics on P2X7 and P2Y receptors in a rat microglial cell line 査読有り
Nakanishi, M., Mori, T., Nishikawa, K., Sawada, M., Kuno, M. and Asada, A.
Anesth Analg 101 巻 ( 5 ) 頁: 1136-1144 2007年5月
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Identification of ligands binding specifically to inflammatory intestinal mucosa using phage display 査読有り
Takagi, T., Arisawa, T., Yamamoto, K., Hirata, I., Nakano, H. and Sawada, M
Clin Exp Pharmacol Physiol 34 巻 ( 4 ) 頁: 286-289 2007年4月
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Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation 査読有り
Hashioka, S., Han, Y.H., Fujii, S., Kato, T., Monji, A., Utsumi, H., Sawada, M., Nakanishi, H. and Kanba, S.
Free Radic Biol Med 42 巻 ( 7 ) 頁: 945-954 2007年4月
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*Neuroprotective effect of exogenous microglia in global brain ischemia 査読有り
IMAI Fumihiro, SUZUKI Hiromi, ODA Jumpei, NINOMIYA Takashi, ONO Kenji, SANO Hirotoshi, SAWADA Makoto
Journal of Cerebral Blood Flow & Metabolism 27 巻 ( 3 ) 頁: 488-500 2007年3月
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Targeting and imaging of brain-specific cell migration 招待有り
65 巻 ( 2 ) 頁: 213-218 2007年2月
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Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia. 査読有り
HASHIOKA Sadayuki, HAN Youn-Hee, FUJII Shunsuke, KATO Takahiro, MONJI Akira, UTSUMI Hideo, SAWADA Makoto, NAKANISHI Hiroshi, KANBA Shigenobu
Neurochemistry International 50 巻 ( 3 ) 頁: 499-506 2007年2月
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Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects 査読有り
NAGATSU Toshiharu, SAWADA Makoto
J Neural Transm Suppl. 72 巻 頁: 113-120 2007年
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Amyloid-beta peptides induce several chemokine mRNA expressions in the primary microglia and Ra2 cell line via PI3K/Akt and/or ERK pathway. 査読有り
ITO Sachiko, SAWADA Makoto, HANEDA Masataka, ISHIDA Yoshi, ISOBE Ken-ichi
Neuroscience Research 56 巻 ( 3 ) 頁: 294-299 2006年11月
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Role of cytokines in inflammatory process in Parkinson's disease 招待有り 査読有り
SAWADA Makoto, IMAMURA Kazuhiro, NAGATSU Toshiharu
Journal of Neural Transmission Supplement 70 巻 頁: 373-381 2006年11月
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Cell cycle-dependent regulation of kainate-induced inward currents in microglia. 査読有り
Yamada Jun, Sawada Makoto, Nakanishi Hiroshi
Biochemical and Biophysical Research Communications 349 巻 ( 3 ) 頁: 913-919 2006年10月
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The intra-arterial injection of microglia protects hippocampal CAI neurons against global ischemia-induced functional deficits in rats. 査読有り
HAYASHI Yoshinori, TOMIMATSU Yoshirou, SUZUKI Hiromi, YAMADA Jun, WU Ziqiang, YAO Hngping, KAGAMIISHI Yoshifumi, TATEISHI Narito, SAWADA Makoto, NAKANISHI Hiroshi
Neuroscience 142 巻 ( 1 ) 頁: 87-96 2006年9月
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*Cellular and Molecular Mechanisms of Parkinson's Disease: Neurotoxins, Causative Genens, and Inflammatory Cytokines. 招待有り 査読有り
NAGATSU Toshiharu, SAWADA Makoto
Cellular and Molecular Neurobiology 26 巻 ( 4-6 ) 頁: 781-802 2006年7月
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Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson's disease: possible implications of glial cells 招待有り 査読有り
Nagatsu, T. and Sawada, M.
J Neural Transm Suppl 71 巻 頁: 53-65 2006年
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Tonic-clonic seizures induce division of neuronal progenitor cells with concomitant changes in expression of neurotrophic factors in the brain of pilocarpine-treated mice 査読有り
HAGIHARA Hideo, HARA Mizumi, TSUNEKAWA Kyoko, NAKAGAWA Yukinori, SAWADA Makoto, NAKANO Kiwako
Molecular Brain Research 139 巻 ( 2 ) 頁: 258-266 2005年
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A lentiviral expression system demonstrates that L* protein of Theiler's murine encephalomyelitis virus (TMEV) has an anti-apoptotic effect in a macrophage cell line 査読有り
HIMEDA Toshiki, OHARA Yoshiro, ASAKURA Kunihiko, KONTANI Yasuhide, SAWADA Makoto
Microb Pathogenesis 38 巻 ( 5-6 ) 頁: 201-207 2005年
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Localization of cyclooxygenase-2 induced following traumatic spinal cord injury 査読有り
ADACHI Kayo, Yimin Yu, SATAKE Kotaro, MATSUYAMA Yukihiro, ISHIGURO Naoki, SAWADA Makoto, HIRATA Yoko, KIUCHI Kazutoshi
Neuroscience Research 51 巻 頁: 73-80 2005年
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Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains 査読有り
Imamura, K., Hishikawa, N., Ono, K., Suzuki, H., Sawada, M., Nagatsu, T., Yoshida, M., Hashizume, Y.
Acta Neuropathol 109 巻 頁: 141-150 2005年
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Amyloid-beta peptides induce cell proliferation and macrophage colony-stimulating factor expression via the PI3-kinase/Akt pathway in cultured Ra2 microglial cells 査読有り
ITO Sachiko, SAWADA Makoto, HANEDA Masataka, FUJII S, OHHASHI Kentaro, KIUCHI Kazatoshi, TAKAHASHI Masahide, ISOBE Ken-ichi
FEBS Letters 579 巻 頁: 1995-2000 2005年
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Peripheral injection of lipopolysaccharide enhances expression of inflammatory cytokines in murine locus coeruleus: possible role of increased norepinephrine turnover 査読有り
KANEKO YokoS, MORI Kenji, NAKASHIMA Akira, SAWADA Makoto, NAGATSU Ikuko, OTA Akira
Journal of Neurochemistry 94 巻 ( 2 ) 頁: 393-404 2005年
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Double-stranded RNA stimulates chemokine expression in microglia through vacuolar pH-dependent activation of intracellular signaling pathways 査読有り
NAKAMICHI Kazuo, SAIKI Megumi, SAWADA Makoto, TAKAYAMA-ITO Mutsuyo, YAMAMURO Yutaka, MORIMOTO Kinjiro, KURANE Ichiro
Journal of Neurochemistry 95 巻 頁: 273-283 2005年
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A lentiviral expression system demonstrates that L* protein of Theiler's murine encephalomyelitis virus (TMEV) is essential for virus growth in a murine macrophage-like cell line 査読有り
HIMEDA Toshiki, OHARA Yoshiro, ASAKURA Kunihiko, KONTANI Yasuhide, MURAKAMI Manabu, SUZUKI Hiromi, SAWADA Makoto
Virus Research 108 巻 頁: 23-28 2005年
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Inhibition of inflammatory cytokine secretion from mouse microglia cells by DHMEQ, an NF-kappaB inhibitor 査読有り
TAKATSUNA Hiroshi, MORITA Shigeru, NAGATSU Toshiharu, SAWADA Makoto, UMEZAWA Kazuo
Biomedecine & Pharmacotherapy 59 巻 頁: 318-322 2005年
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Vitamin K2 ameliorates experimental autoimmune encephalomyelitis in Lewis rats 査読有り
MORIYA Masayuki, NAKATSUJI Yuji, OKUNO Tatsusada, HAMASAKI Toshimitsu, SAWADA Makoto, SAKODA Saburo
Journal of Neuroimmunology 59 巻 頁: 318-322 2005年
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Rabies virus-induced activation of MAPK and NF-kappaB signaling pathways regulates expression of CXC and CC chemokine ligands in microglia 査読有り
NAKAMICHI Kazuo, SAIKI Megumi, SAWADA Makoto, YAMAMURO Yutaka, MORIMOTO Kinjiro, KURANE Ichiro
Journal of Virology 79 巻 頁: 11801-11812 2005年
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Inflammatory process in Parkinson's disease: role for cytokines 招待有り 査読有り
Nagatsu, T., Sawada, M.
Curr Pharm Res 11 巻 頁: 999-1016 2005年
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Superoxide production at phagosomal cup/phagosome through betal protein kinase C during FcgammaR-mediated phagocytosis in microglia.
T.Ueyama, M.R.Lennartz, Y.Noda, T.Kobayashi, Y.Shirai, K.Rikitake, T.Yamasaki, S.Hayashi, N.Sakai, H.Seguchi, M.Sawada, H.Sumitomo and N.Saito
J. Immunol. 173 巻 ( 7 ) 頁: 4582-4589 2004年
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Pepstatin A induces extracellular acidification distinct from aspartic protease inhibition in microglial cell lines.
M.Okada, S.Irie, M.Sawada, R.Urae, A.Urae, N.Iwata, N.Ozaki, K.Akazawa andH.Nakanishi
Glia 43 巻 ( 2 ) 頁: 167-174 2003年
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Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains.
K.Imamura, N.Hishikawa, M.Sawada, T.Nagatsu, M.Yoshida,and Y.Hashizume
Acta Neuropathol(Berl) 106 巻 ( 6 ) 頁: 518-526 2003年
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Microglial cell cycle-associated proteins control microglial proliferation in vivo and in vitro and are regulated by GM-CSF and density-dependent inhibition.
K.Koguchi, Y.Nakatsuji, T.Okuno, M.Sawada and S.Sakoda
J. Neurosci Res 74 巻 ( 6 ) 頁: 898-905 2003年
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Preservation of hematopoietic properties in transplanted bone marrow cells in the brain.
K.Ono, K.Yoshihara, H.Suzuki, K.F.Tanaka, T.Takii, K.Onozaki and M.Sawada
J. Neurosci Res 72 巻 ( 4 ) 頁: 503-507 2003年
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The HIV-1 Nef protein and phagocyte NADPH oxidase activation.
F.Vilhardt, O.Plastre, M.Sawada, K.Suzuki, M.Wiznerowicz. E.Kiyokawa, D.Trono and K.H.Krause
J.Biol Chem 277 巻 ( 44 ) 頁: 42136-42143 2002年
-
Distinct Cell death mechamisms by Theiler's murine encephalomyelitis virus (TMEV) infection in microglia and macrophage
Y.Ohara, T.Himeda, K.Asakura and M.Sawada
Netrosci Lett. 327 巻 ( 1 ) 頁: 41-44 2002年
-
Existence of functional b1-and b2-adrenergic receptors on microglia
K.F.Tanaka, H.Kashima, H.Suzuki, K.Ono and M.Sawada
J Neurosci. Res. 70 巻 ( 2 ) 頁: 232-237 2002年
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Glial cell line-derived neurotrophic factor enhances survival of GM-CSF dependent rat GMIR1-microglial cells
K.Salimi, K.Moser, B.Zassler, M.Reindl, N.Embacher, C.Schermer, C.Weis, J.Marksteiner, M.Sawada and C. Humpel
Neurosci Res. 43 巻 ( 3 ) 頁: 221-229 2002年
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alpha-Synuclein forms a complex with transcription factor Elk-1
A.Iwata, S.Miura, I Kanazawa, M.Sawada and N.Nukina
J. Neurochem. 77 巻 ( 1 ) 頁: 239-252 2001年
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Preservation of neurotrophin expression in microglia that migrate into the gerbil's brain across the blood brain barrier
H.Suzuki, F.Imai, T.Kanno and M.Sawada
Neurosci. Lett. 312 巻 ( 2 ) 頁: 95-98 2001年
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ミクログリア 21世紀の神経免疫学展望
医学の歩み 別冊 巻 頁: 32-35 2001年
-
ミクログリアの脳保護作用と脳特異的薬物輸送
現代医学 48 巻 ( 3 ) 頁: 615-620 2001年
-
ミクログリア細胞を用いた脳疾患の治療戦略
神経研究の進歩 ( 45 ) 頁: 63-72 2001年
-
Activation mechanism of brain microglia in patients with diffuse neurofibrillary tangles with calcification: a comparison with Alzheimer disease
K.Imamura, M.Sawada, N.Ozaki, H.Naito, N.Iwata, R.Ishsihara, T.Takeuchi and H.Shibayama
Alzheimer Dis. Assoc. Disord. 15 巻 ( 1 ) 頁: 45-50 2001年
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Age-dependent and tissue-specific CAG rereat instability occurs in mouse knock-in for a mutant Huntington's disease gene
H.Ishiguro, K.Yamada, H.Sawada, K.Nishii, N.Ichino, M.Sawada, Y.Kurosawa,N.Matsushita, K.Kobayashi, J.Goto,H.Hashida, N.Masuda, I.Kanazawa and T.Nagatsu
J. Neurosci. Res. 65 巻 ( 4 ) 頁: 289-297 2001年
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Histamine production by cultured microglial cells of the mouse
Y.Katoh, M.Niimi, Y.Yamamoto, T.Kawamura, T.Morimoto-Ishizuka, M.Sawada, H.Takemori and A.YamatodaniH.Takemori and A.Yamatodani
Neurosci. Lett. 305 巻 ( 3 ) 頁: 181-184 2001年
-
Differentiated regulation of allo-antigen presentation by different types of murine microglial cell lines.
T.Kanzawa, M.Sawada, K.Kato, K.Yamamoto, H.Mori and R.Tanaka
J Neurosci Res 62 巻 ( 3 ) 頁: 383-388 2000年
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Impaired cytokine production by peripheral blood mononuclear cells and monocytes/macrophages in Parkinson's disease.
Y.Hasegawa, T.Inagaki, M.Sawada and A.Suzumura
Acta Neurol. Scand. 101 巻 ( 3 ) 頁: 159-164 2000年
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Increased soluble tumor necrosis factor receptor levels in the serum of elderly people
Y.Hasegawa, M.Sawada, N.Ozaki, T.Inagaki and A.Suzumura
Gelontology 46 巻 ( 4 ) 頁: 185-188 2000年
-
Cell cycle regulation and apoptosis
Clin. Neurosci 18 巻 頁: 407-409 2000年
-
Distinctive regulation of antigen presentation by different type of murine microglial clones
J. Neurosci Res. 62 巻 頁: 383-388 2000年
-
Temporal fluctuations of voltage-gated proton currents in rat spinal microglia via pH-dependent and-independent mechanisms
H.Morihata, J.Kawasaki, H.Sakai, M.Sawada, T.Tsutada and M.Kuno
Neurosci. Res. 38 巻 ( 3 ) 頁: 265-271 2000年
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細胞周期とアポトーシス
Clin. Neurosci 18 巻 頁: 407-409 2000年
-
細胞を使って脳の疾患を治療する試み
治療 82 巻 頁: 2200-2202 2000年
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Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions
Neurosci Lett 272 巻 頁: 127-130 1999年
-
Brain cytokine network and microglia
Jpn. J. Neuropsychopharmacol. 19 巻 頁: 151-154 1999年
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Apoptosis and Necrosis
Seibutusiryoubunnseki 22 巻 頁: 93-100 1999年
-
Serial analysis of gene expression in a microglial cell line
Glia 28 巻 頁: 265-71 1999年
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Effects of phosphodiesterase inhibitors on cytokine production by microglia
Mult Scler 5 巻 頁: 126-133 1999年
-
Effects of vesnarinone on cytokine production and activation of murine microglia
Life Sci 64 巻 頁: 1197-1203 1999年
-
Ibudilast suppresses TNFalpha production by glial cells functioning mainly as type (]G0003[) phosphodiesterase inhibitor in the CNS
Brain Res 837 巻 頁: 203-212 1999年
-
Interliukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia
J Neurochem 72 巻 頁: 1466-1471 1999年
-
Migration of exogenous immature hematopoietic cells into adult mouse brain parenchyma under GFP-expressing bone marrow
Biochem Biophys Res Commun 262 巻 頁: 610-614 1999年
-
Enhanced Fos expression in the hippocampus of El mice after short-term vestibular stimulation
Neurosci Lett 271 巻 頁: 105-108 1999年
-
ミクログリアの新規な性質と脳での役割-ミクログリアは脳で何をしているか
細胞工学 18 巻 頁: 550-558 1999年
-
アポトーシスとネクローシス
生物試料分析 22 巻 頁: 93-100 1999年
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脳のサイトカインネットワークとミクログリアの脳での役割
日本神経精神薬理学雑誌 19 巻 頁: 151-154 1999年
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"Tryptophan and its metabolite, kynurenine, stimulate expression of nerve growth factor in cultured mouse astroglial cells."
Neurosci. Lett. 244 巻 頁: 17-20 1998年
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Pathophysiological significance of cytokine network in the brain
Japan Scienctific Societies Press 頁: 217-228 1998年
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Appotosis and Microglia
Nippon Yakurigaku Zasshi 112 巻 頁: 15-19 1998年
-
Differentiation-specific mRNA expression of a mouse bibptential glial cell line
Neurosci. Lett 258 巻 頁: 21-24 1998年
-
Cytokines and Neural differentiation
Clinical Neuroscience 16 巻 頁: 406-408 1998年
-
Insulin-like growth factor-I analogue prevents apoptosis mediated through an interleukin-Ib converting enzyme(caspase-1)-like protease of cerebellar external tranular layer neurons : developmental stage-specific mechanisms of neuronal cell death.
Neuroscience 84 巻 頁: 89-100 1998年
-
Microglial NO induces delayed neuronal death following acute injury in the striatum
Eur J Neurosci 10 巻 頁: 1613-1620 1998年
-
Production of interleukin-12 and expression of its receptors by murine microglia.
Brain Research 787 巻 頁: 139-142 1998年
-
Brain-specific gene expression by immortalized microglial cell-mediated gene transfer in the mammalian brain.
FEBS Lett. 433 巻 頁: 37-40 1998年
-
ミクログリアとアポートシス
日本薬学雑誌 112 巻 頁: 15-19 1998年
-
神経系の分化とサイトカイン
Clinical Neuroscience 16 巻 頁: 406-408 1998年
-
Changes in gene expression in mouse astrocytes during long-term. serial cultivation
Tissue Culture Research Communication 16 巻 頁: 129-135 1997年
-
Possible strategy of therapies against brain intractable diseases by brain-speciffic gene delivery technique with immortalized microglia
Nippon-Iji-Shinpo 3844 巻 頁: 28-30 1997年
-
Expression of Ly-6C on microglia in the developing and adult mouse brain.
Neurosci. Lett. 239 巻 頁: 17-20 1997年
-
Migration activity microglia and macrophages into rat brain.
Neurosci. Lett. 237 巻 頁: 49-52 1997年
-
Cytokine network in the brain
Tissue Culture Research Communication 42 巻 ( 3 ) 頁: 504-511 1997年
-
ミクログリア細胞株を用いた脳疾患の治療の可能性
日本醫事新報 3844 巻 頁: 28-30 1997年
-
脳のサイトカインネットワーク
蛋白質核酸酵素 42 巻 ( 3 ) 頁: 504-511 1997年
-
ER-MP抗原陽性ミクログリアの存在について
Journal of Neural Transmission 15 巻 頁: 221-227 1996年
-
Expression pattern of messenger RNAs for prostanoid receptors in glial cell cultures
Brain Research 707 巻 頁: 282-287 1996年
-
Presence of ER-MP antigen positive microglia
Tissue Culture Research Communications 15 巻 頁: 221-227 1996年
-
Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulationg factor
Brain Research 713 巻 頁: 192-198 1996年
-
ミクログリアの発生と多様性
細胞 27 巻 ( 5 ) 頁: 193-198 1995年
-
cDNA cloning of a thromboxane A2 receptor from rat astrocytes
Biochimica et Biophysica Acta 1265 巻 頁: 220-223 1995年
-
Apoptosis-regulating factors which bind adenovirus E1A and E1B proteins
Tissue Culture Research Communication 13 巻 ( 16 ) 頁: 1884-1889 1995年
-
Neoptenin in immunological reactions in cancer and in the brain-- Possible involuement of macrophage and microglia
Pteridnes 6 巻 頁: 190-193 1995年
-
Insulin prevents apoptosis of external granular layer neurons in rat cerebellar slice cultures
Neuroscience Letters 199 巻 頁: 37-40 1995年
-
Developmental origin and multi-functional subtypes of microglia
The Cell 27 巻 ( 5 ) 頁: 193-198 1995年
-
Expression of glutamate transporters in cultured glial cells
Neuroscience Letters 188 巻 頁: 140-142 1995年
-
The bipotential glial progenitor cell line can develop into both oligodendrocytes and astrocytes in the mouse forebrain
Neuroscience Letters 188 巻 ( 1 ) 頁: 1-4 1995年
-
Cytokine network in the central nervous system and its roles in growth and differentiation of glial and neuronal cells
International Journal of Developmental Neuroscience 13 巻 ( 3・4 ) 頁: 253-264 1995年
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Induction of functional interleukin-2 receptor in mouse microglia
Journal of Neurochemistry 64 巻 頁: 1973-1979 1995年
-
Programmed cell death of PC12 induced by adenovirus EIA
Nueroscience Letters 191 巻 頁: 173-176 1995年
-
アデノウイルスE1AとE1Bに結合するアポトーシス調節因子
実験医学 13 巻 ( 16 ) 頁: 1884-1889 1995年
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Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression
Journal of Neuroimmunology 53 巻 頁: 209-218 1994年
-
Production of interleukin-10 by mouse glial cells in culture
Biochemical and Biophysical Research Communications 205 巻 ( 3 ) 頁: 1907-1915 1994年
-
Induction of MHC class II antigen expression on murine microglia by interleukin-3
Journal of Neuroimmunology 55 巻 頁: 119-125 1994年
-
Expression of cytokines during glial differentiation
Brain Research 656 巻 頁: 141-146 1994年
-
Production of interleukin-5 by mouse astrocytes and microglia in culture.
Neuroscience Letters ( 155 ) 頁: 175-178 1993年
-
Brain vessels near muscle autografts are sites for entry of isogeneic macrophage into brain
Experimental Neurology 124 巻 頁: 219-230 1993年
-
Gene expression commonly observed in both immune and neruous system
"Annual Review of Immunology, 1993" 頁: 134-142 1993年
-
Effects of microglia-derived cytokines on astrocyte proliferation. (共著)
Restoractive Newology and Neuvoscience ( 5 ) 頁: 347-352 1993年
-
Transforming Growth Factor-β Suppresses Activation and Proliferation of Microglia in Vitro. (共著)
Journal of Immunology ( 151 ) 頁: 2150-2158 1993年
-
Expression of cytokine receptors in cultured neural and glial cells.
Neuroscience Letters ( 160 ) 頁: 131-134 1993年
-
Regulation of astrocyte proliferation by prostaglandin E2 and the α subtype of protein kinase C.
Brain Research ( 613 ) 頁: 67-73 1993年
-
免疫系と神経系に共通する遺伝子発現
Annual Review免疫1993 頁: 134-142 1993年
-
TNF alpha induces IL-6 production by astrocytes but not by microglia.
Brain Research 583 巻 ( 1 ) 頁: 296-299 1992年
-
"A PCR method for the quantitative assessment of mRNA for laminin A, B1, and B2 chains(共著)"
Kidney International ( 42 ) 頁: 764-769 1992年
-
Establishment of mouse oligodendrocyte/type-2 astrocyte lineage cell line by transfection with origin-defective Simian virus 40 DNA(共著)
Cell Structure and Function ( 17 ) 頁: 325-333 1992年
-
Induction of cytokines in glial cells by trans activator of human T cell lymphotropic virus type I.
FEBS Letters 313 巻 ( 1 ) 頁: 47-50 1992年
-
Down regulation of CD4 expression in cultured microglia by immunosuppressants and lipopolysaccharide.
Biochemical and Biophysical Research Communications 189 巻 ( 2 ) 頁: 869-876 1992年
-
培養ミクログリアの免疫組織学的検討
臨床神経学 31 巻 ( 2 ) 頁: 127-134 1991年
-
Functional and immunohistochemical studies of cultured rat microglia. (共著)
Clinical Neurology 31 巻 ( 2 ) 頁: 127-134 1991年
-
NIHにおける相同組換えによるGene Targettingの現状
蛋白質核酸酵素 35 巻 ( 13 ) 1990年
-
"Tyrosine hydroxylase, tryptophan hydroxylase, biopterin and neopterin in the brain of anorexia nervosa. (共著)"
Journal of Neural Transmission 80 巻 頁: 145-150 1990年
-
Effects of colony stimulating factors on isolated microglia in vitro. (共著)
Journal of Neuroimmunology 30 巻 ( 2-3 ) 頁: 111-120 1990年
-
HTLV-I trans activator induces class I MHC antigen expression in glial cells.
Journal of Virology 64 巻 ( 8 ) 頁: 4002-4006 1990年
-
Activation and proliferation of the isolated microglia by colony stimulating factor-1 and possible involvement of protein kinase C.
Brain Research 509 巻 ( 1 ) 頁: 119-124 1990年
-
Production of granulocyte/macrophage colony-stimulating factor by cultured astrocytes. (共著)
Biochemical and Biophysical Research Communications 169 巻 ( 2 ) 頁: 719-724 1990年
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Gene targeting at NIH
"Proteins, Nucleic Acids and Enzymes" 35 巻 ( 13 ) 1990年
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Production of tumor necrosis factor-alpha by microglia and astrocytes in culture.
Brain Research 491 巻 ( 2 ) 頁: 394-397 1989年
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神経伝達物質についての最近のアプローチ
メディカル・イムノロジー 16 巻 ( 1 ) 1988年
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Tryptophan hydroxylase activity in brain slices.
International Journal of Biochemistry 20 巻 ( 10 ) 頁: 1033-1038 1988年
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Resent approach to neurotransmitters
Medical Immunology 16 巻 ( 1 ) 1988年
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ビオプテリンとネオプテリンの蛍光偏光測定
蛋白質・核酸・酵素 31 巻 1987年
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Combined use of urinary pteridines measured by radioimmunoassays and polyamines as tumor markers. (共著)
Biogenic Amines 4/ 巻 ( 1 ) 頁: 433-443 1987年
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A factor inducing differentiation of the human nonocytic cell line U-937 produced by 12-O-tetradecanoylpholbol 13-acetate-treated U-937. (共著)
Japanese Journal of Cancer Research 78 巻 頁: 219-222 1987年
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"Tyrosine hydroxylase, tryptophan hydroxylase, biopterin and neopterin in postmortem brains from control and patients with Alzheimer-type dementia."
Journal of Neurochemistry 48 巻 頁: 760-764 1987年
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"Effects of thyrotropin releasing hormone and its analogue, DN1417, on biopterin concentration and tryptophan hydroxylation in rat raphe slices."
Life Sciences 41 巻 頁: 2733-2737 1987年
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Polarization fluoroimmunoassay of biopterin and neopterin(共著)
"Proteins, Nucleic Acids, and Enzymes" 31 巻 1987年
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Stimulation of serotonin autoreceptor prevents the calcium-calmodulin-dependent increase of serotonin biosynthesis in rat raphe slices.
Journal of Neurochemistry 46 巻 頁: 963-967 1986年
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A sensitive assay of GTP cyclohydrolase I activity in rat and human tissues using radioimmunoassay of neopterin.
Analytical Biochemistry 154 巻 頁: 361-366 1986年
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Effects of adrenergic drugs on the activities of tryptophan hydroxylase in midbrain raphe slices of the rat.
Neurochemistry International 8 巻 ( 3 ) 頁: 413-416 1986年
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(6R)-Tetra-hydrobiopterin increases the activity of tryptophan hydroxylase in rat raphe slices.
Journal of Neurochemistry 47 巻 頁: 1544-1547 1986年
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Preparation and cofactor activity of(6S)-tetrahydrobiopterin. (共著)
Chemistry Express 1 巻 ( 7 ) 頁: 403-406 1986年
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"Changes in activities of tryptophan hydroxylase and cyclic AMP-dependent and calcium-calmodulin-dependent protein kinases in raphe serotonergic neurons of 5,7-dihydroxytryptamine-treated rats."
Neurochemistry International 7 巻 ( 5 ) 頁: 761-763 1985年
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"Synthesis, localization and release of 5-hydroxytryptamine in neuroblastoma x glioma NG108-15 hybrid cells. (共著)"
Brain Research 361 巻 ( 1 ) 頁: 77-90 1985年
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Tryptophan hydroxylase activity in the brains of controls and parkinsonian patients.
Journal of Neural Transmission 62 巻 頁: 107-115 1985年
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"Kinetic analysis of the inhibition of tryptophan hydroxylase, a pteridine=requiring monooxygenase, by oudenone and its derivatives."
Biogenic Amines 1 巻 頁: 121-178 1984年
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Radioimmunoassay for neopterin in body fluid and tissues. (共著)
Analytical Biochemistry 141 巻 頁: 472-480 1984年
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Elevated levels of polyamines and radioimmuoassayable 6-hydroxymethy1-pterin-like compound in urine from cancer patients. (共著)
Biogenic Amines 1 巻 頁: 51-62 1984年
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Polarization fluoroimmunoassay of biopterin and neopterin in human urine.
Clinica Chimica Acta 138 巻 頁: 275-282 1984年
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Serotonin in neuroblastoma x glioma NG108-15 hybrid cells. (共著)
Neurochemistry International 5 巻 ( 5 ) 頁: 589-601 1983年
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Tryptophan hydroxlase system in brain tissue slices assayed by high-performance liquid chromatography. (共著)
Neurochemistry International 5 巻 ( 5 ) 頁: 603-609 1983年
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Demonstration of tryptophan 5-monooxygenase activity in human brain by high-performance liquid chromatography with fluorometric detection. (共著)
Biochemistry International 2 巻 ( 3 ) 頁: 295-303 1981年