Organization
Nagoya University Hospital Assistant Professor of Hospital
Title
Assistant Professor of Hospital
OCHIAI Yosuke
Degree 2
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Doctor of Medicine （ 2020.3 Nagoya University ）
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Bachelor (Medicine) （ 2008.3 Hirosaki University ）
Research Interests 1
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Bile duct cancer, pancreatic cancer, sarcoma, neuro-cancer science
Research Areas 2
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Life Science / Tumor biology / neuro-cancer science
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Life Science / Digestive surgery / Bile duct cancer, pancreatic cancer, sarcoma
Research History 3
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Nagoya University Assistant Professor of Hospital
2025.10
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Columbia University Medical Center Division of Digestive & Liver disease Associated Research Scientist
2024.2 - 2025.9
Country：United States
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Columbia University Medical Center Division of Digestive & Liver disease Postdoctoral Research Scientist
2020.2 - 2024.1
Country：United States
Education 2
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Nagoya University
2017 - 2020.3
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Hirosaki University
2002.4 - 2008.3
Professional Memberships 5
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The Japan Society of Gastroenterological Surgery
2014
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Japan surgical society
2010
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臨床腫瘍学会
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日本癌治療学会
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The Japanese Cancer Association
Papers 20
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Netrin-1 Promotes Pancreatic Tumorigenesis and Innervation through NEO1. Reviewed Open Access
Kobayashi H, Ochiai Y, Arai J, Hata M, Wu F, Sunagawa M, Iida T, Baba T, Malagola E, Tanaka T, Jiang Z, White RA, Zhi X, Qian J, Waterbury QT, Tu R, Zheng B, Zeng Y, Zheng H, Zhang P, Li S, Zamechek LB, LaBella JS, Sugie T, Enomoto A, Eltzschig HK, Palermo CF, Chio IIC, Olive KP, Wang TC.
Cancer Res. 2026.4
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Trefoil Factor Family 1 Inhibits the Development of Hepatocellular Carcinoma by Regulating β-Catenin Activation. Reviewed
Ochiai Y, Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T, Nagino M.
Hepatology 2020.3
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Nociceptive neurons promote gastric tumour progression via a CGRP-RAMP1 axis. Reviewed
Zhi X, Wu F, Qian J, Ochiai Y, Lian G, Malagola E, Zheng B, Tu R, Zeng Y, Kobayashi H, Xia Z, Wang R, Peng Y, Shi Q, Chen D, Ryeom SW, Wang TC.
Nature 2025.4
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Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury. Reviewed
Malagola E, Vasciaveo A, Ochiai Y, Kim W, Zheng B, Zanella L, Wang ALE, Middelhoff M, Nienhüser H, Deng L, Wu F, Waterbury QT, Belin B, LaBella J, Zamechek LB, Wong MH, Li L, Guha C, Cheng CW, Yan KS, Califano A, Wang TC.
Cell 2024.1
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Tff2 marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injury. Reviewed
Tu R, Zheng HL, Zheng B, Zhong Q, Qian J, Yu Q, Wu F, Shiokawa T, Ochiai Y, Kobayashi H, Waterbury QT, Zamechek L, Gao Y, Takahashi S, Mizuno S, Huang CM, Li P, Hayakawa Y, Wang TC.
Gut 2026.4
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Electroporation-Induced Gastric Cancer Models Through Epithelial-Specific Genetic Modifications. Reviewed Open Access
Arai J, Hata M, Ochiai Y, Hayakawa Y, Ryeom S, Wang TC, Kobayashi H, Zheng B, Wu F, Qian J, Zeng Y, Zheng H, Zhang P, Li S, Zamechek L, Kinoshita H, Filko P, Olive KP
Gastro Hep Adv. 2026.3
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Gastrin-dependent expansion of Cck2r+ corpus progenitors accelerates ulcer healing and inhibits gastric dysplasia. Reviewed Open Access
Zheng B, Kobayashi H, Tu R, Huang K, Zhi X, Lian G, Wu F, Qian J, Ochiai Y, Waterbury QT, Malagola E, Lu J, Hata M, Zeng Y, Zheng H, Zhang P, Li S, Zamechek L, Wang X, Chen F, Wang TC.
Gut 2026.1
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Bone marrow neutrophil density regulates myelopoiesis during obesity and weight loss. Reviewed Open Access
Waterbury QT, Qian J, Zheng H, Dirnberger A, Olson OC, White RA, Wu F, Kobayashi H, Malagola E, Ochiai Y, Tu R, Zheng B, Diaby A, Nagendra H, LaBella JS, Zamechek L, Korner J, Emiliano AB, Ferrante AW Jr, Passegué E, Wang TC.
J Exp Med 2025.9
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A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis. Reviewed Open Access
Qian J, Ma C, Waterbury QT, Zhi X, Moon CS, Tu R, Kobayashi H, Wu F, Zheng B, Zeng Y, Zheng H, Ochiai Y, White RA, Harle DW, LaBella JS, Zamechek LB, ZhongMing Hu L, Moy RH, Han AS, Daugherty BL, Lederman S, Wang TC.
Cancer Cell 2025.8
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Protocol for automated graph-based clustering of single-cell RNA- seq data with application in mouse intestinal stem cells. Reviewed Open Access
Wang ALE, Zanella L, Ochiai Y, Golinelli L, Califano A, Malagola E, Vasciaveo A.
STAR Protoc 2025.7
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p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasia in Barrett's oesophagus. Reviewed Open Access
Lian G, Malagola E, Wei C, Shi Q, Zhao J, Hata M, Kobayashi H, Ochiai Y, Zheng B, Zhi X, Wu F, Tu R, Nápoles OC, Su W, Li L, Jing C, Chen M, Zamechek L, Friedman R, Nowicki-Osuch K, Quante M, Que J, Wang TC.
Gut 2025.1
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Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression. Reviewed Open Access
Kobayashi H, Iida T, Ochiai Y, Malagola E, Zhi X, White RA, Qian J, Wu F, Waterbury QT, Tu R, Zheng B, LaBella JS, Zamechek LB, Ogura A, Woods SL, Worthley DL, Enomoto A, Wang TC.
Cancer Discov. 2025.1
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An optimized protocol for isolation of murine pancreatic single cells with high yield and purity. Reviewed
Wu F, Jiang Z, Qian J, Kobayashi H, Waterbury QT, White RA, Ochiai Y, Zhi X, Tu R, Zheng B, Shi Q, Zamechek LB, Wang TC.
STAR Protoc 2024.3
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Microbial-Dependent Recruitment of Immature Myeloid Cells Promotes Intestinal Regeneration. Reviewed
Jiang Z, Waterbury QT, Malagola E, Fu N, Kim W, Ochiai Y, Wu F, Guha C, Shawber CJ, Yan KS, Wang TC.
Cell Mol Gastroenterol Hepatol. 2023.10
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Adult enteric Dclk1-positive glial and neuronal cells reveal distinct responses to acute intestinal injury. Reviewed
Middelhoff M, Valenti G, Tomassoni L, Ochiai Y, Belin B, Takahashi R, Malagola E, Nienhüser H, Finlayson M, Hayakawa Y, Zamechek LB, Renz BW, Westphalen CB, Quante M, Margolis KG, Sims PA, Laise P, Califano A, Rao M, Gershon MD, Wang TC.
Am J Physiol Gastrointest Liver Physiol. 2022.3
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Trefoil factor family 2 inhibits cholangiocarcinogenesis by regulating the PTEN pathway in mice. Reviewed
Hasebe K, Yamaguchi J, Kokuryo T, Yokoyama Y, Ochiai Y, Nagino M, Ebata T.
Carcinogenesis 2021.12
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Premalignant pancreatic cells seed stealth metastasis in distant organs in mice. Reviewed
Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T, Ochiai Y, Nagino M.
Oncogene 2021.12
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Acute Intestinal Inflammation Depletes/Recruits Histamine-Expressing Myeloid Cells From the Bone Marrow Leading to Exhaustion of MB-HSCs. Reviewed
Fu N, Wu F, Jiang Z, Kim W, Ruan T, Malagola E, Ochiai Y, Nápoles OC, Valenti G, White RA, Belin BR, Zamechek LB, LaBella JS, Wang TC.
Cell Mol Gastroenterol Hepatol. 2020.11
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Single-Incision Laparoscopic Splenectomy for an Unruptured Aneurysm of the Splenic Artery. Reviewed
Toyoda Y, Igami T, Ochiai Y, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Nagino M.
Med Princ Pract 2017.11
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Laparoscopic surgery for the treatment of a ruptured aneurysm of the right gastric artery: a case report. Reviewed
Toyoda Y, Kyokane T, Kawai T, Watanabe K, Koide F, Ochiai Y, Asai Y, Igami T, Kuze S.
Asian J Endosc Surg. 2016.9