2025/04/11 更新

写真a

ナカヤ ミチオ
仲矢 道雄
NAKAYA Michio
所属
環境医学研究所 生体適応・防御研究部門 教授
大学院担当
大学院医学系研究科
職名
教授
 

論文 1

  1. Elevated PRELP expression in heart and liver fibrosis promotes collagen production Open Access

    Yamauchi, Y; Mieno, H; Suetsugu, H; Watanabe, H; Nakaya, M

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   734 巻   頁: 150785   2024年11月

     詳細を見る

    記述言語:英語   出版者・発行元:Biochemical and Biophysical Research Communications  

    Fibrosis results from the excessive production of extracellular matrix proteins by myofibroblasts. It has recently been reported that in the heart, myofibroblasts develop chondrocyte-like properties following myocardial infarction as fibrosis progresses and tissues stiffen. However, the nature of these chondrocyte-like myofibroblasts remains unclear. In this study, we found that the expression of the proline- and arginine-rich end leucine-rich repeat protein (PRELP) was upregulated in hearts and livers stiffened by fibrosis with chronic inflammation. Moreover, we established that Prelp was specifically expressed in chondrocyte-like myofibroblasts. Prelp expression was found to be regulated by the transcription factor SOX9, and in cardiac and liver myofibroblasts, Prelp-knockdown was observed to reduce collagen expression. These findings reveal that PRELP is specifically expressed in chondrocyte-like myofibroblasts and that it promotes collagen production. PRELP could thus serve as a novel therapeutic target for treating fibrosis.

    DOI: 10.1016/j.bbrc.2024.150785

    Open Access

    Web of Science

    Scopus

    PubMed