Organization
Institute for Glyco-core Research Designated Assistant Professor
Title
Designated Assistant Professor
External link
HUANG Chengcheng
Degree 3
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PhD （ 2015.3 Saitama University ）
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MS （ 2011.6 Shenyang Pharmaceutical University（China） ）
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Bachelor （ 2008.7 Shenyang Pharmaceutical University ）
Research Interests 3
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Free oligosaccharides
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Ngly1/PNGase
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Sialic acid
Research Areas 1
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Life Science / Molecular biology
Papers 15
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Rat hepatocytes secrete free oligosaccharides Reviewed Open Access
Chengcheng Huang, Junichi Seino, Akinobu Honda, Haruhiko Fujihira, Di Wu, Kyohei Okahara, Shinobu Kitazume, Shuichi Nakaya, Ken Kitajima, Chihiro Sato, Tadashi Suzuki
Journal of biological chemistry 2024.2
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Occurrence of free N-glycans with a single GlcNAc at the reducing termini in animal sera Reviewed
Chengcheng Huang, Junichi Seino, Haruhiko Fujihira, Keiko Sato, Reiko Fujinawa, Zeynep Sumer-Bayraktar, Nozomi Ishii, Ichiro Matsuo, Shuichi Nakaya, Tadashi Suzuki
Glycobiology 2022.3
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Purification method for serum free glycans Reviewed
Chengcheng Huang, Tadashi Suzuki
Glycoscience Protocols (GlycoPODv2) 2022.3
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The occurrence of non-glycosylated forms of N‐glycoprotein upon proteasome inhibition does not confirm cytosolic deglycosylation. Reviewed
FEBS Lett Vol. 32 ( 4 ) page： 314 2020.1
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Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells Reviewed Open Access
Huang C, Harada Y, Hosomi A, Masahara-Negishi Y, Seino J, Fujihira H, Funakoshi Y, Suzuki T, Dohmae N, and Suzuki T.
Proc Natl Acad Sci U S A. Vol. 112 ( 5 ) page： 1398 2015.1
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Hydrolytic activity of yeast oligosaccharyltransferase is enhanced when misfolded proteins accumulate in the endoplasmic reticulum Reviewed
Sheng-Tao Li, Hiroto Hirayama, Chengcheng Huang, Tsugiyo Matsuda, Ritsuko Oka,Takahiro Yamasaki, Daisuke Kohda and Tadashi Suzuki
Febs J 2023.12
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Free glycans derived from O-mannosylated glycoproteins suggest the presence of an O-glycoprotein degradation pathway in yeast. Reviewed Open Access
Hirayama H, Matsuda T, Tsuchiya Y, Oka R, Seino J, Huang C, Nakajima K, Noda Y, Shichino Y, Iwasaki S, Suzuki T.
Journal of biological chemistry Vol. 294 ( 44 ) 2019.7
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A New Fluorogenic Probe for the Detection of endo-β-N-Acetylglucosaminidase. Reviewed
Ishii N, Sunaga C, Sano K, Huang C, Iino K, Matsuzaki Y, Suzuki T, Matsuo I.
Chembiochem. Vol. 19 ( 7 ) 2018.4
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Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1 Reviewed International coauthorship Open Access
Galeone A, Han SY, Huang C, Hosomi A, Suzuki T, Jafar-Nejad H.
eLife 2017.8
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Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene. Reviewed Open Access
9. Fujihira H, Masahara-Negishi Y, Tamura M, Huang C, Harada Y, Wakana S, Takakura D, Kawasaki N, Taniguchi N, Kondoh G, Yamashita T, Funakoshi Y, Suzuki T.
PLoS Genet. 2017.4
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Non-lysosomal Degradation of Singly Phosphorylated Oligosaccharides Initiated by the Action of a Cytosolic Endo-β-N-acetylglucosaminidase. Reviewed Open Access
Journal of biological Chemistry Vol. 291 ( 15 ) 2016.4
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The cytoplasmic peptide:N-glycanase (NGLY1) - Structure, expression and cellular functions. Invited Reviewed Open Access
Suzuki T, Huang C, Fujihira H.
Gene Vol. 577 ( 1 ) 2016.2
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Autophagy regulates the stability of sialin, a lysosomal sialic transporter. Reviewed Open Access
Huang C, Seino J, Wang L, Haga Y, Suzuki T.
Biosci Biotechnol Biochem. Vol. 79 ( 4 ) 2015.4
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Basal autophagy is required for the efficient catabolism of sialyloligosaccharides Reviewed Open Access
Seino J, Wang L, Harada Y, Huang C, Ishii K, Mizushima N, Suzuki T.
Journal of Biological Chemistry Vol. 288 ( 37 ) 2013.9
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Calcium regulates Caveolin-1 expression at the transcription level. Reviewed
Biochem Biophys Res Commun. Vol. 426 ( 3 ) 2012.9