Updated on 2025/10/23

写真a

 
HUANG Chengcheng
 
Organization
Institute for Glyco-core Research Designated Assistant Professor
Title
Designated Assistant Professor
External link

Degree 3

  1. PhD ( 2015.3   Saitama University ) 

  2. MS ( 2011.6   Shenyang Pharmaceutical University(China) ) 

  3. Bachelor ( 2008.7   Shenyang Pharmaceutical University ) 

Research Interests 3

  1. Free oligosaccharides

  2. Ngly1/PNGase

  3. Sialic acid

Research Areas 1

  1. Life Science / Molecular biology

Awards 1

  1. The Japanese Society of Carbohydrate Research Awardee

    2024.9   Japanese Society of Carbohydrate Research.  

    huang chengcheng

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    Award type:Award from Japanese society, conference, symposium, etc. 

 

Papers 18

  1. Studies on the Formation Mechanism for Free Glycans. Invited Reviewed

    Huang C.

    TIGG     2025.5

  2. Free oligosaccharides in serum. Invited Reviewed

    Huang C, Honda A, Suzuki T.

    BBA Advances     2025.1

  3. Rat hepatocytes secrete free oligosaccharides Reviewed Open Access

    Chengcheng Huang, Junichi Seino, Akinobu Honda, Haruhiko Fujihira, Di Wu, Kyohei Okahara, Shinobu Kitazume, Shuichi Nakaya, Ken Kitajima, Chihiro Sato, Tadashi Suzuki

    Journal of biological chemistry     2024.2

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    Authorship:Lead author  

    DOI: 10.1016/j.jbc.2024.105712

    Open Access

  4. Occurrence of free N-glycans with a single GlcNAc at the reducing termini in animal sera Reviewed

    Chengcheng Huang, Junichi Seino, Haruhiko Fujihira, Keiko Sato, Reiko Fujinawa, Zeynep Sumer-Bayraktar, Nozomi Ishii, Ichiro Matsuo, Shuichi Nakaya, Tadashi Suzuki

    Glycobiology     2022.3

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    Authorship:Lead author   Language:English  

    DOI: 10.1093/glycob/cwab124

  5. Purification method for serum free glycans Reviewed

    Chengcheng Huang, Tadashi Suzuki

    Glycoscience Protocols (GlycoPODv2)     2022.3

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    Authorship:Lead author, Corresponding author   Language:English  

  6. The occurrence of non-glycosylated forms of N‐glycoprotein upon proteasome inhibition does not confirm cytosolic deglycosylation. Reviewed

    FEBS Lett   Vol. 32 ( 4 ) page: 314   2020.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  7. Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells Reviewed Open Access

    Huang C, Harada Y, Hosomi A, Masahara-Negishi Y, Seino J, Fujihira H, Funakoshi Y, Suzuki T, Dohmae N, and Suzuki T.

    Proc Natl Acad Sci U S A.   Vol. 112 ( 5 ) page: 1398   2015.1

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  8. Occurrence of free glycans in salmonid serum. Reviewed

    Honda A, Seino J, Huang C, Nakano M, Suzuki T.

    Biochem Biophys Res Commun.     2024.11

  9. Hydrolytic activity of yeast oligosaccharyltransferase is enhanced when misfolded proteins accumulate in the endoplasmic reticulum Reviewed

    Sheng-Tao Li, Hiroto Hirayama, Chengcheng Huang, Tsugiyo Matsuda, Ritsuko Oka,Takahiro Yamasaki, Daisuke Kohda and Tadashi Suzuki

    Febs J     2023.12

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    Authorship:Lead author  

    DOI: 10.1111/febs.17011

  10. Free glycans derived from O-mannosylated glycoproteins suggest the presence of an O-glycoprotein degradation pathway in yeast. Reviewed Open Access

    Hirayama H, Matsuda T, Tsuchiya Y, Oka R, Seino J, Huang C, Nakajima K, Noda Y, Shichino Y, Iwasaki S, Suzuki T.

    Journal of biological chemistry   Vol. 294 ( 44 )   2019.7

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    Language:English  

    DOI: 10.1074/jbc.RA119.009491

    Open Access

  11. A New Fluorogenic Probe for the Detection of endo-β-N-Acetylglucosaminidase. Reviewed

    Ishii N, Sunaga C, Sano K, Huang C, Iino K, Matsuzaki Y, Suzuki T, Matsuo I.

    Chembiochem.   Vol. 19 ( 7 )   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cbic.201700662

  12. Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1 Reviewed International coauthorship Open Access

    Galeone A, Han SY, Huang C, Hosomi A, Suzuki T, Jafar-Nejad H.

    eLife     2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.27612

    Open Access

  13. Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene. Reviewed Open Access

    9. Fujihira H, Masahara-Negishi Y, Tamura M, Huang C, Harada Y, Wakana S, Takakura D, Kawasaki N, Taniguchi N, Kondoh G, Yamashita T, Funakoshi Y, Suzuki T.

    PLoS Genet.     2017.4

  14. Non-lysosomal Degradation of Singly Phosphorylated Oligosaccharides Initiated by the Action of a Cytosolic Endo-β-N-acetylglucosaminidase. Reviewed Open Access

    Journal of biological Chemistry   Vol. 291 ( 15 )   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.m115.685313

    Open Access

  15. The cytoplasmic peptide:N-glycanase (NGLY1) - Structure, expression and cellular functions. Invited Reviewed Open Access

    Suzuki T, Huang C, Fujihira H.

    Gene   Vol. 577 ( 1 )   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.gene.2015.11.021

  16. Autophagy regulates the stability of sialin, a lysosomal sialic transporter. Reviewed Open Access

    Huang C, Seino J, Wang L, Haga Y, Suzuki T.

    Biosci Biotechnol Biochem.   Vol. 79 ( 4 )   2015.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/09168451.2014.991682

  17. Basal autophagy is required for the efficient catabolism of sialyloligosaccharides Reviewed Open Access

    Seino J, Wang L, Harada Y, Huang C, Ishii K, Mizushima N, Suzuki T.

    Journal of Biological Chemistry   Vol. 288 ( 37 )   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M113.464503

    Open Access

  18. Calcium regulates Caveolin-1 expression at the transcription level. Reviewed

    Biochem Biophys Res Commun.   Vol. 426 ( 3 )   2012.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2012.08.079

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Presentations 5

  1. Studies on the Formation Mechanism for Free Glycans. Invited

    Huang Chengcheng

    The 43rd Annual Meeting of Japanese Society of Carbohydrate Research.  2024.9.12  Japanese Society of Carbohydrate Research

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    Event date: 2024.9

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  2. 1. Minimalist tetrazine sugar labeling of N-Glycoproteins in vertebrate cells for functional analysis. International coauthorship International conference

    Chengcheng Huang, Di Wu, Ashlyn S. Hillman ,Mary W. N. Burns, Hane Masaya, Chihiro Sato, Ken Kitajima,Joseph M. Fox, Jennifer J. Kohler

    Glyco-core symposium 2025.  2025.9.24  iGCORE Nagoya University

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    Event date: 2025.9

    Language:English   Presentation type:Poster presentation  

    Venue:Nagoya University  

  3. Investigation of interacting partners of polysialic acid on the NCAM by a photocrosslinking techonology International coauthorship

    Chengcheng Huang, Masaya Hane, Di Wu, Rohit Sai Reddy Konada, Chihiro Sato, Jennifer Jean Kohler

    The 97th annual meeting of the Japanese Biochemistry Society.  2024.11.7 

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    Event date: 2024.11

    Language:English   Presentation type:Poster presentation  

  4. Investigation of interacting partners of polysialic acid on the NCAM by a photocrosslinking techonology

    Chengcheng Huang, Masaya Hane, Di Wu, Rohit Sai Reddy Konada, Chihiro Sato, Jennifer Jean Kohler

    The 43rd Annual Meeting of Japanese Society of Carbohydrate Research.  2024.9.13  Japanese Society of Carbohydrate Research

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    Event date: 2024.9

    Language:English   Presentation type:Poster presentation  

    Venue:Yokohama  

  5. Investigation of interacting partners of polysialic acid on the NCAM by a photocrosslinking techonology. International conference

    Chengcheng Huang, Masaya Hane, Di Wu, Rohit Sai Reddy Konada, Chihiro Sato, Jennifer Jean Kohler

    Glyco-core symposium 2024  2024.7.16 

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    Event date: 2024.7

    Language:English   Presentation type:Poster presentation