Updated on 2024/09/17

写真a

 
TSUJIKAWA Koichiro
 
Organization
Graduate School of Medicine Designated assistant professor
Title
Designated assistant professor
Contact information
メールアドレス
Homepage
https://orcid.org/0009-0005-3443-2439

Degree 1

  1. 博士（医学） （ 2024.3   名古屋大学 ） 

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Research Areas 1

  1. Life Science / Developmental biology

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Research History 1

  1. Nagoya University   Graduate School of Medicine Center for Research of Laboratory Animals and Medical Research Engineering Division for Advanced Medical Research   Designated assistant professor

    2024.4

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Professional Memberships 4

  1. 日本解剖学会

  2. 日本神経学会

  3. 日本内科学会

  4. 日本発生生物学会

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Papers 2

  1. Endothelial cells regulate alveolar morphogenesis by constructing basement membranes acting as a scaffold for myofibroblasts

    Watanabe-Takano H., Kato K., Oguri-Nakamura E., Ishii T., Kobayashi K., Murata T., Tsujikawa K., Miyata T., Kubota Y., Hanada Y., Nishiyama K., Watabe T., Fässler R., Ishii H., Mochizuki N., Fukuhara S.

    Nature Communications   Vol. 15 ( 1 ) page： 1622   2024.12

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    Language：English   Publisher：Nature Communications  

    Alveologenesis is a spatially coordinated morphogenetic event, during which alveolar myofibroblasts surround the terminal sacs constructed by epithelial cells and endothelial cells (ECs), then contract to form secondary septa to generate alveoli in the lungs. Recent studies have demonstrated the important role of alveolar ECs in this morphogenetic event. However, the mechanisms underlying EC-mediated alveologenesis remain unknown. Herein, we show that ECs regulate alveologenesis by constructing basement membranes (BMs) acting as a scaffold for myofibroblasts to induce septa formation through activating mechanical signaling. Rap1, a small GTPase of the Ras superfamily, is known to stimulate integrin-mediated cell adhesions. EC-specific Rap1-deficient (Rap1iECKO) mice exhibit impaired septa formation and hypo-alveolarization due to the decreased mechanical signaling in myofibroblasts. In Rap1iECKO mice, ECs fail to stimulate integrin β1 to recruit Collagen type IV (Col-4) into BMs required for myofibroblast-mediated septa formation. Consistently, EC-specific integrin β1-deficient mice show hypo-alveolarization, defective mechanical signaling in myofibroblasts, and disorganized BMs. These data demonstrate that alveolar ECs promote integrin β1-mediated Col-4 recruitment in a Rap1-dependent manner, thereby constructing BMs acting as a scaffold for myofibroblasts to induce mechanical signal-mediated alveologenesis. Thus, this study unveils a mechanism of organ morphogenesis mediated by ECs through intrinsic functions.

    DOI： 10.1038/s41467-024-45910-y

    Scopus

    PubMed

  2. Developmentally interdependent stretcher-compressor relationship between the embryonic brain and the surrounding scalp in the preosteogenic head Reviewed

    Koichiro Tsujikawa, Kanako Saito, Arata Nagasaka, Takaki Miyata

    Developmental Dynamics   Vol. 251 ( 7 ) page： 1107 - 1122   2022.7

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/dvdy.451

    Other Link： https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.451

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MISC 2

  1. CSF pressure in fetal mice in utero: External factors pressurize the intraventricular space

    Koichiro Tsujikawa, Reina Muramatsu, Takaki Miyata

    bioRxiv     2024.9

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    Authorship：Lead author,　Corresponding author   Language：English  

    DOI： https://doi.org/10.1101/2024.09.08.611845

    DOI： 10.1101/2024.09.08.611845

  2. Mechanical collaboration between the embryonic brain and the surrounding scalp tissues

    Koichiro Tsujikawa, Kanako Saito, Arata Nagasaka, Takaki Miyata

        2021.5

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    Authorship：Lead author   Language：English   Publishing type：Internal/External technical report, pre-print, etc.  

    DOI： 10.1101/2021.05.05.442865

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