Updated on 2024/05/01

写真a

 
ARAFUKA Shusei
 
Organization
Nagoya University Hospital Clinical Oncology and Chemotherapy Assistant professor of hospital
Title
Assistant professor of hospital

Degree 1

  1. Bachelor(Medicine) ( 2014.3   Nagoya University ) 

Education 1

  1. Nagoya University

 

Papers 5

  1. Neuropathological substrate of incident dementia in older patients with schizophrenia: A clinicopathological study

    Arafuka, S; Fujishiro, H; Torii, Y; Sekiguchi, H; Habuchi, C; Miwa, A; Yoshida, M; Iritani, S; Iwasaki, Y; Ikeda, M; Ozaki, N

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 78 ( 1 ) page: 29 - 40   2024.1

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    Language:English   Publisher:Psychiatry and Clinical Neurosciences  

    Aim: Clinical studies reported that patients with schizophrenia are at a higher risk of developing dementia than people without schizophrenia. However, early neuropathological studies have shown that the incidence of Alzheimer's disease (AD) in schizophrenia patients does not differ from that in controls. These inconsistent results may be attributable to the inclusion of non-AD dementia, but there have been few clinicopathological studies in older patients with schizophrenia based on the current neuropathological classification. This study aimed to investigate the neuropathological basis of incident dementia in older patients with schizophrenia. Methods: We systematically examined 32 brains of old patients with schizophrenia using standardized pathological methods. The severity of dementia-related neuropathologies was analyzed using standardized semiquantitative assessments. After excluding patients who fulfilled the neuropathological criteria, clinicopathological variables were compared between patients with and without incident dementia to identify potential differences. Results: Seven patients fulfilled the pathological criteria for AD (n = 3), argyrophilic grain disease (AGD) (n = 2), dementia with Lewy bodies (n = 1), and AGD/progressive supranuclear palsy (n = 1). Among 25 patients for whom a neuropathological diagnosis was not obtained, 10 had dementia, but the clinicopathological findings did not differ from the remaining 15 patients without dementia. Conclusion: Two types of older schizophrenia patient present dementia: patients with co-existing neurodegenerative disease and patients who do not meet pathological criteria based on the current classification. To understand the neurobiological aspects of incident dementia in older patients with schizophrenia, further clinicopathological studies are needed that do not simply analyze incident dementia as a comorbidity of conventional dementia-related neuropathologies.

    DOI: 10.1111/pcn.13597

    Web of Science

    Scopus

    PubMed

  2. Neuropathological hallmarks in autopsied cases with mitochondrial diseases caused by the mitochondrial 3243A>G mutation

    Miyahara H., Tamai C., Inoue M., Sekiguchi K., Tahara D., Tahara N., Takeda K., Arafuka S., Moriyoshi H., Koizumi R., Akagi A., Riku Y., Sone J., Yoshida M., Ihara K., Iwasaki Y.

    Brain Pathology   Vol. 33 ( 6 ) page: e13199   2023.11

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    Language:English   Publisher:Brain Pathology  

    The mitochondrial (m.) 3243A>G mutation is known to be associated with various mitochondrial diseases including mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Their clinical symptoms have been estimated to occur with an increased mitochondrial DNA (mtDNA) heteroplasmy and reduced activity of oxidative phosphorylation (OXPHOS) complexes, but their trends in the central nervous system remain unknown. Six autopsied mutant cases and three disease control cases without the mutation were enrolled in this study. The mutant cases had a disease duration of 1–27 years. Five of six mutant cases were compatible with MELAS. In the mutant cases, cortical lesions including a laminar necrosis were frequently observed in the parietal, lateral temporal, and occipital lobes; less frequently in the frontal lobe including precentral gyrus; and not at all in the medial temporal lobe. The mtDNA heteroplasmy in brain tissue samples of the mutant cases was strikingly high, ranging from 53.8% to 85.2%. The medial temporal lobe was preserved despite an inhospitable environment having high levels of mtDNA heteroplasmy and lactic acid. OXPHOS complex I was widely decreased in the mutant cases. The swelling of smooth muscle cells in the vessels on the leptomeninges, with immunoreactivity (IR) against mitochondria antibody, and a decreased nuclear/cytoplasmic ratio of choroidal epithelial cells were observed in all mutant cases but in none without the mutation. Common neuropathological findings such as cortical laminar necrosis and basal ganglia calcification were not always observed in the mutant cases. A high level of mtDNA heteroplasmy was observed throughout the brain in spite of heterogeneous cortical lesions. A lack of medial temporal lesion, mitochondrial vasculopathy in vessels on the leptomeninges, and an increased cytoplasmic size of epithelial cells in the choroid plexus could be neuropathological hallmarks helpful in the diagnosis of mitochondrial diseases.

    DOI: 10.1111/bpa.13199

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    PubMed

  3. Late-onset panic disorder as the initial presentation in autopsy-confirmed dementia with Lewy bodies

    Arafuka, S; Sekiguchi, H; Fujishiro, H; Iritani, S; Torii, Y; Habuchi, C; Yoshida, M; Iwasaki, Y; Ozaki, N; Fujita, K

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 77 ( 4 ) page: 242 - 244   2023.4

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    Language:English   Publisher:Psychiatry and Clinical Neurosciences  

    DOI: 10.1111/pcn.13532

    Web of Science

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    PubMed

  4. Temporal trajectories of proposed biomarkers in psychiatric-onset prodromal dementia with Lewy bodies: a case report

    Fujishiro, H; Arafuka, S; Ogasawara, K; Iwamoto, K; Miyata, S; Torii, Y; Iritani, S; Ozaki, N

    PSYCHOGERIATRICS   Vol. 23 ( 1 ) page: 196 - 200   2023.1

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    Language:English   Publisher:Psychogeriatrics  

    DOI: 10.1111/psyg.12922

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    PubMed

  5. Striatal <SUP>123</SUP>I-2β-carbomethoxy-3b-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single-photon emission computed tomography demonstrates nigral degeneration in the early stage of behavioural variant frontotemporal dementia: an autopsy case with frontotemporal lobar degeneration with trans-activation response DNA protein 43 type B

    Arafuka, S; Fujishiro, H; Iritani, S; Torii, Y; Miwa, A; Yabata, H; Sekiguchi, H; Habuchi, C; Kawashima, K; Yoshida, M; Iwasaki, Y; Ozaki, N

    PSYCHOGERIATRICS   Vol. 22 ( 4 ) page: 580 - 585   2022.7

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    Language:English   Publisher:Psychogeriatrics  

    DOI: 10.1111/psyg.12842

    Web of Science

    Scopus

    PubMed