2024/07/01 更新

写真a

ソン ジアン
宋 澤安
SONG Zean
所属
大学院医学系研究科 附属医学教育研究支援センター 先端領域支援部門 特任助教
職名
特任助教
 

論文 7

  1. Association between milk consumption in middle age and frailty in later life: The Aichi Workers' cohort study

    Hong, YJ; Otsuka, R; Song, Z; Fukuda, C; Tajima, R; Lin, JY; Hibino, M; Kobayashi, M; He, YP; Matsunaga, M; Ota, A; Nakano, Y; Li, YY; Tamakoshi, K; Yatsuya, H

    GERIATRICS & GERONTOLOGY INTERNATIONAL     2024年6月

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    記述言語:英語   出版者・発行元:Geriatrics and Gerontology International  

    Aim: Several studies have shown that dairy consumption in old age is effective in preventing frailty. However, there is a lack of evidence regarding the association between milk consumption during middle age and the development of frailty in old age. Therefore, we carried out an investigation to explore the association between milk consumption during middle age and development of frailty examined after over 15 years of follow up in a long-term cohort study in Japan. Methods: We studied 265 participants aged 60–79 years (212 men and 53 women) in 2018, who participated in both the baseline survey in 2002 and the frailty assessment in 2018. The amount of milk consumption (g/day) at baseline was age- and energy-adjusted, and classified into three categories (no, low and high consumption: 0 g/day, ≤135.86 g/day, >135.86 g/day in men and 0 g/day, ≤126.44 g/day, >126.44 g/day in women). Odds ratios (OR) and 95% confidence intervals (CI) for prefrailty/frailty after adjusting for lifestyles at baseline, stratified by sex, were estimated using logistic regression analysis. Results: The prevalence of prefrailty/frailty in 2018 was 37.7% and 28.3% in men and women, respectively. Milk consumption categories were inversely associated with the prevalence of prefrailty/frailty in men (OR 0.34, 95% CI 0.14–0.84 in low consumption; OR 0.31, 95% CI 0.10–0.95 in high consumption; P < 0.05), but not in women (OR 0.53, 95% CI 0.11–2.65; P = 0.44). Conclusions: In this study, milk intake in middle-aged men was inversely associated with the prevalence of prefrailty/frailty later in life. Geriatr Gerontol Int 2024; ••: ••–••.

    DOI: 10.1111/ggi.14916

    Web of Science

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  2. Associations of overweight and obesity with the risk of cardiovascular disease according to metabolic risk factors among middle-aged Japanese workers: The Aichi Workers’ cohort study

    Al-shoaibi A.A.A., Li Y., Song Z., Hong Y.J., Chiang C., Nakano Y., Hirakawa Y., Matsunaga M., Ota A., Tamakoshi K., Yatsuya H.

    Obesity Research and Clinical Practice   18 巻 ( 2 ) 頁: 101 - 108   2024年3月

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    記述言語:英語   出版者・発行元:Obesity Research and Clinical Practice  

    Background: The association between obesity and cardiovascular disease (CVD) remains unclear, particularly for those with established CVD risk factors. We analyzed follow-up data from the Aichi Workers’ Cohort Study. We studied the association between the degree of obesity and risk of CVD and its subtypes specifically among individuals with hypertension, hyper-low-density lipoprotein (LDL)-cholesterolemia, or diabetes. Methods: Pooled data of 8972 adults (7076 men and 1896 women) who were recruited between 2002 and 2008 were used in the current analysis. We used multivariable Cox proportional hazard model to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between the degree of obesity assessed with body mass index (BMI) and the risk of CVD and its subtypes, i.e., coronary heart disease (CHD) and stroke. Results: During a median of 12 years, there were 197 CVDs (80 CHDs and 117 strokes). BMI ≥ 27.5 compared to 21.0–22.9 kg/m2 was positively and significantly associated with the risks of CVD, CHD, and total stroke. Hypertension, hyper-LDL-cholesterolemia, and diabetes mediated 15.9%, 5.8%, and 8.7% of obesity-CVD associations, respectively, and 28.3% by their combination. In the stratified analyses by the presence of risk factors, BMI ≥ 25.0 (overweight/obesity) compared to BMI < 25 kg/m2 was associated with a higher risk of CVD in those with and without hypertension, but only with hyper-LDL-cholesterolemia, and without diabetes. Conclusions: Overweight/obesity was associated with the risk of CVD and its subtypes. About 30% of the risk was explained by hypertension, hyper-LDL-cholesterolemia, and diabetes, of which hypertension accounted for approximately the half of the explained risk. However, overweight/obesity increased the risk of CVD even in those without hypertension. These findings highlight the importance of controlling and preventing overweight/obesity regardless of chronic disease status.

    DOI: 10.1016/j.orcp.2024.02.006

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  3. Nonrestorative Sleep and Type 2 Diabetes Incidence: the Aichi Workers' Cohort Study

    Lin, JY; Song, Z; Li, YY; Chiang, CF; Hirakawa, Y; Nakano, Y; Hong, YJ; Matsunaga, M; Ota, A; Tamakoshi, K; Yatsuya, H

    Journal of Epidemiology   advpub 巻 ( 0 )   2024年

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    記述言語:英語   出版者・発行元:日本疫学会  

    DOI: 10.2188/jea.je20230184

    Web of Science

    PubMed

    CiNii Research

  4. Association of psychological factors with advanced-level functional competency: Findings from the Aichi workers' cohort study, 2002-2019

    Saif-Ur-Rahman, K; Hong, YJ; Li, YY; Matsunaga, M; Song, Z; Shimoda, M; Al-Shoaibi, A; He, YP; Mamun, MR; Hirano, Y; Chiang, CF; Hirakawa, Y; Aoyama, A; Tamakoshi, K; Ota, A; Otsuka, R; Yatsuya, H

    HELIYON   9 巻 ( 11 ) 頁: e21931   2023年11月

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    記述言語:英語   出版者・発行元:Heliyon  

    Objective: This study examined the longitudinal association of perceived stress, ikigai, and having someone one can count on in middle age with the advanced-level functional competency in older age, which is crucial for the maintenance of independent life among older adults. The issue is especially relevant in super-aged countries like contemporary Japan, where more and more older people live in a household consisting only of older people. Methods: Data were collected in 2019 from a total of 1692 retirees of the Aichi Workers’ Cohort Study participants in which baseline survey including psychological factors was conducted during their employment in 2002. Japan Science and Technology Agency Index of Competence (JST-IC) was used to measure the advanced-level functional competency. Multivariable-adjusted odds ratios (ORs) were obtained for having low JST-IC in later life by the degrees of psychological factors reported in the middle age adjusting for the presence of depressive mood in 2019. Results: Those who were not sure about ikigai (OR: 2.02, 95 % CI: 1.33 to 3.08) and who have no one to count on (OR: 2.19, 95 % CI: 1.52 to 3.16) in the middle age were significantly associated with low JST-IC after retirement. Having much stress was significantly inversely associated with a low JST-IC (OR: 0.69, 95 % CI: 0.50 to 0.97). Conclusion: Having ikigai and someone reliable, and stress during middle age might play a role in preventing impaired advanced-level functional competency. Improved ikigai and increased social interaction and support might improve functional competency. Further research might explore avenues for improving ikigai.

    DOI: 10.1016/j.heliyon.2023.e21931

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  5. Good death for people living with dementia: a qualitative study

    Mamun, MR; Hirakawa, Y; Saif-Ur-Rahman, KM; Hong, YJ; Song, Z; Yoshida, Y; Yatsuya, H

    BMC GERIATRICS   23 巻 ( 1 ) 頁: 665   2023年10月

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    記述言語:英語   出版者・発行元:BMC Geriatrics  

    Background: Ensuring a good death is one of the primary objectives of palliative care and end-of-life care. There is insufficient evidence regarding what defines a good death for people living with dementia. Obtaining an understanding of what constitutes a good death could help improve dementia care. This study aimed to explore how multiple stakeholders perceive a good death for people living with dementia. Methods: This qualitative study was carried out across six prefectures in Japan. Enrollment of participants took place within dementia outpatient clinics, hospitals, daycare centers, and community centers. A total of thirty-three in-depth interviews with people living with dementia, physicians, and nurses were conducted. Six focus group discussions were performed with family caregivers and care workers. Verbatim transcripts of the interviews were prepared, and inductive content analysis was used to examine the data. Findings: Regarding the perception of a good death, the following themes were derived: (1) painless death; (2) dying in a preferred environment; (3) family’s coping with loss; (4) maintaining regular life; (5) living with respect; and (6) preparation for death. All these themes are interrelated. Participants viewed a good death as a process rather than a single event. Conclusion: This study identifies crucial components of a good death for people living with dementia. The findings could be used to improve dementia care.

    DOI: 10.1186/s12877-023-04395-y

    Web of Science

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  6. Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting

    Al-Shoaibi, AAA; Li, YY; Song, Z; Chiang, CF; Hirakawa, Y; Saif-Ur-Rahman, KM; Shimoda, M; Nakano, Y; Matsunaga, M; Aoyama, A; Tamakoshi, K; Ota, A; Yatsuya, H

    Journal of Atherosclerosis and Thrombosis   30 巻 ( 5 ) 頁: 455 - 466   2023年5月

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    記述言語:英語   出版者・発行元:一般社団法人 日本動脈硬化学会  

    Aims: The associations between low-density lipoprotein cholesterol (LDL-C) and the risk of cardiovascular disease (CVD) subtypes are not well established among the Japanese population. This study used longitudinal data from the Aichi Workers’ Cohort Study to explore the association between LDL-C levels and the risk of coronary heart disease (CHD) and stroke subtypes. Methods: Pooled data of 8966 adults (7093men and 1903 women) who were recruited between (2002) and (2008) were used for the current analysis. Propensity scores for the LDL-C categories were generated using multinomial logistic regression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from the inverse probability weighted Cox proportional hazards model for LDL-C category associations with risks of CHD, stroke subtypes, and CVD. Results: During a median follow-up of 12 years, 122 strokes (57 ischemic strokes, 25 intracerebral hemorrhage, and 40 unknown subtypes) and 82 cases of CHD were observed. LDL-C 160– mg/dL compared to LDL-C 100– 119 mg/dL was positively and significantly associated with the risk of CHD (HR: 4.56; 95% CI: 1.91–10.9) but not with ischemic stroke (HR: 0.99; 95% CI: 0.44–2.22). LDL-C was inversely associated with the risk of intracerebral hemorrhage (P for trend=0.009). Conclusion: In middle-aged Japanese workers, LDL-C was significantly and positively associated with CHD, but not with ischemic stroke. LDL-C was inversely significantly associated with intracerebral hemorrhage.

    DOI: 10.5551/jat.63519

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    CiNii Research

  7. Long-term variability and change trend of systolic blood pressure and risk of type 2 diabetes mellitus in middle-aged Japanese individuals: findings of the Aichi Workers' Cohort Study

    Song, ZA; He, YP; Chiang, CF; Al-Shoaibi, AAA; Saif-Ur-Rahman, KM; Mamun, MR; Aoyama, A; Hirakawa, Y; Matsunaga, M; Ota, A; Tamakoshi, K; Li, YY; Yatsuya, H

    HYPERTENSION RESEARCH   45 巻 ( 11 ) 頁: 1772 - 1780   2022年11月

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    記述言語:英語   出版者・発行元:Hypertension Research  

    Studies have reported that short-term blood pressure (BP) variability (BPV) is associated with type 2 diabetes mellitus (T2DM) incidence, but the association with long-term BPV remains unclear. The present study investigated the associations of long-term BPV as well as the time trend of BP changes over time with the incidence of T2DM. This study followed a cohort of 3017 Japanese individuals (2446 male, 571 female) aged 36–65 years from 2007 through March 31, 2019. The root-mean-square error (RMSE) and the slope of systolic BP (SBP) change regressed on year were calculated individually using SBP values obtained from 2003 to baseline (2007). A multivariable Cox proportional hazard model was applied to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for tertiles of SBP RMSE and continuous SBP slopes adjusted for age, sex, smoking status, regular exercise, sodium intake, family history of diabetes, sleep disorder, body mass index (BMI), SBP, and fasting blood glucose (FBG) at baseline, and BMI slope from 2003 to 2007. The highest RMSE tertile compared to the lowest was associated with a significantly higher incidence of T2DM after adjusting for covariates (HR: 1.79, 95% CI: 1.15, 2.78). The slope was also significantly associated with T2DM incidence until baseline SBP and FBG were adjusted (HR: 1.03, 95% CI: 0.99, 1.07). In conclusion, long-term SBP variability was significantly associated with an increased incidence of T2DM independent of baseline age, sex, BMI, SBP, FBG, lifestyle factors and BMI slope from 2003 until baseline.

    DOI: 10.1038/s41440-022-00993-2

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講演・口頭発表等 17

  1. Measures of Long-Term Systolic Blood Pressure Variability and Their Associations with The Risk of Type 2 Diabetes Mellitus.

    International Society of Hypertension 2022 

  2. 日本人中年労働者の職業ストレスと心血管疾患発症の関連:愛知職域コホート研究

    第97回日本産業衛生学会 

  3. Fatigue is Associated with Future Development of Cardiovascular Disease in Middle-age Japanese Workers: findings of Aichi Workers Cohort Study.

  4. 長期血圧変動指標による2型糖尿病発症予測能の変化。

    第7回日本糖尿病・生活習慣病ヒューマンデータ学会年次学術集会 

  5. Long-Term Variability and Change Trend of Systolic Blood Pressure and Risk of Type 2 Diabetes Mellitus in Middle-Aged Japanese.

  6. Association of Presence of Non-Specific Physical Complaints with Future Development of Cardiovascular Disease in Middle-Aged Japanese Workers: Finding From the Aichi Workers Cohort Study. 国際会議

    American Heart Association EPI:LIFESTYLE 2024 

  7. Predictive Value Of Long-term Systolic Blood Pressure Variability For The Development Of Type 2 Diabetes Mellitus. 国際会議

    American Heart Association EPI: LIFESTYLE 2023 

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    記述言語:英語   会議種別:口頭発表(一般)  

  8. Association of low-density lipoprotein cholesterol with risk of coronary heart disease and stroke among middle-aged Japanese workers: An analysis using inverse probability weighting 国際会議

    American Heart Association EPI: LIFESTYLE 2022 

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    記述言語:英語  

  9. 中年期の牛乳摂取と老年期フレイル発症の関連.

    第68回東海公衆衛生学会学術大会 

  10. 20歳から中年期までの体重変化は、中年期から老年期までの体重変化から独立したフレイル発症関連要因である。

    第7回日本糖尿病・生活習慣病ヒューマンデータ学会年次学術集会 

  11. "Association of Adipocyte Insulin Resistance with Risk of Diabetes Incidents in Japanese Workers"

  12. 朝食欠食と抑うつ発症の関連:愛知職域コホート研究

    第97回日本産業衛生学会 

  13. Obesity is Associated With High Medical Costs in Japanese Patients with Hypertension

  14. "20歳代の体重増加はフレイル発症関連要因である―愛 知職域コホート研究"

    第33回日本疫学会学術集会 

  15. Cross-sectional association between fasting blood glucose and chewing difficulty

  16. 肥満の有無の心血管危険因子集積数と心血管疾患発症リスク及び集団寄与危険割合:愛知職域コホート研究

    第59回日本循環器病予防学会学術集会 

  17. Non-restorative Sleep and Diabetes incidence: the Aichi Workers' Cohort Study.

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科研費 1

  1. コロナ禍での持病悪化要因と持病有無が就労関連要因の心血管発症リスクに及ぼす影響

    研究課題/研究課題番号:23K24607  2024年4月 - 2027年3月

    科学研究費助成事業  基盤研究(B)

    八谷 寛, 大塚 礼, 李 媛英, 玉腰 浩司, 太田 充彦, 山田 宏哉, 松永 眞章, 高田 碧, 宋 澤安

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    担当区分:研究分担者 

    長期間追跡調査である愛知職域コホート研究において、就労関連要因と心血管疾患発症との関連が高血圧や糖尿病といった危険因子(持病)の有無によって異なるかを検討する。追跡調査と生活習慣等の繰り返し調査により、自覚ストレスや職場ストレッサーと持病との関連を検討し、コロナ禍等の環境変化の影響を考察する。データベースの統計解析とともに、他の職域コホートとのデータ統合研究を行う準備を行う。