2025/09/16 更新

写真a

ソン ジアン
宋 澤安
SONG Zean
所属
大学院医学系研究科 附属医学教育研究支援センター 先端領域支援部門 特任助教
職名
特任助教

学位 1

  1. 博士(医学) ( 2024年3月   名古屋大学 ) 

研究分野 1

  1. ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

受賞 1

  1. Young Investigtors Fellowships

    2022年10月  

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    受賞区分:国際学会・会議・シンポジウム等の賞 

 

論文 11

  1. Utility of long-term systolic blood pressure variability for predicting the development of type 2 diabetes mellitus Open Access

    Song, Z; Li, YY; Hong, YJ; Chiang, CF; Matsunaga, M; He, YP; Ota, A; Tamakoshi, K; Yatsuya, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   87 巻 ( 2 ) 頁: 220 - 236   2025年5月

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    記述言語:英語   出版者・発行元:Nagoya Journal of Medical Science  

    Better identification of individuals at high risk for type 2 diabetes mellitus (T2DM) requires risk-prediction models incorporating novel predictors. Accordingly, this study aimed to evaluate the merits of including long-term systolic blood pressure variability (SBPV) in predicting T2DM incidence in a Japanese cohort of 3017 participants (2446 men, 571 women; age, 36–65 years) in 2007, who were followed up until March 2019. Consecutive SBP values, recorded between 2003 and 2007, were regressed annually for each participant. The slope and root-mean-square error of the regression line were calculated for each individual to represent SBPV. The significance of SBPV was examined by adding it to a multivariate Cox model incorporating age, sex, smoking status, regular exercise, family history of diabetes, body mass index, blood levels of triglycerides, high-density lipoprotein cholesterol, and fasting blood glucose. The c-index, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to compare the performance of the prediction models without (Model 1) and with (Model 2) SBPV. During the 9.8-year follow-up period, 135 participants developed T2DM. Although a statistically significant difference in c-index between Model 1 (0.785) and Model 2 (0.786) was not found, the NRI (8.312% [p < 0.001]) and IDI (0.700% [p = 0.012]) demonstrated that the performance of Model 2 improved compared with Model 1. In conclusion, results suggested that long-term SBPV slightly improved predictive utility for T2DM when added to a conventional prediction model. The study was registered at University Hospital Medical Information Network Clinical Trial registry (UMIN000052544, https://www.umin.ac.jp/).

    DOI: 10.18999/nagjms.87.2.220

    Open Access

    Web of Science

    Scopus

    PubMed

  2. 勤労者における朝食欠食と抑うつ発症の関連:愛知職域コホート研究 Open Access

    日比野 瑞歩, 李 媛英, 宋 澤安, 髙田 碧, 洪 英在, 福田 知里, 王 爽, 桶川 龍世, 西尾 七海, 服部 優奈, 太田 充彦, 玉腰 浩司, 八谷 寛

    東海公衆衛生雑誌   12 巻 ( 2 ) 頁: 135 - 142   2025年3月

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    記述言語:日本語   出版者・発行元:東海公衆衛生学会  

    <p><b>目的</b> 中部地方の自治体職員を対象に,朝食欠食と5年後の抑うつ状態発症との関連を,愛知職域コホート研究のデータを用いて検討することを目的とした。</p><p><b>方法</b> 愛知職域コホート研究の2013年のベースライン調査に参加した20-54歳の対象者のうちベースライン時に抑うつがない,あるいはうつ病の治療中ではない者のうち2018年調査にも参加した2004人 (男性1452人,女性552人)を研究対象とした。抑うつ状態の評価はCenter for Epidemiologic Studies Depression Scale日本語短縮 (11項目)を使用し,8点以上を抑うつとみなした。朝食欠食は朝食摂取頻度が週6回以下と定義した。さらに,5年間の朝食欠食の変化を「非欠食 (2013年)→非欠食 (2018年)」,「欠食→非欠食」,「非欠食→欠食」,「欠食→欠食」の4パターンに分けた分析も実施した。多変量ロジスティック回帰分析を用いて,性 (男性,女性[閉経前],女性[閉経後]),年齢,学歴,配偶者・14歳未満の子供の同居の有無,肥満 (BMI≧25 kg/m<sup>2</sup>),喫煙状況,運動頻度,アルコール摂取量,睡眠時間,ストレス,ファミリー・ワーク・コンフリクト,ワーク・ファミリー・コンフリクトを調整し,2018年の抑うつ発症のオッズ比 (OR)と95%信頼区間 (CI)を推定した。</p><p><b>結果</b> 2018年に新たに抑うつ状態となったのは261人 (13%)であった。朝食欠食と抑うつ発症には調整要因に独立した統計学的に有意な正の関連が認められた (OR: 1.39,95%CI: 1.01-1.90)。朝食欠食の変化パターン別の分析でも「非欠食→非欠食」群に比べて「欠食→欠食」群は抑うつ発症と有意な正の関連を示した (OR: 1.53,95%CI: 1.06-2.21)。</p><p><b>結論</b> 朝食欠食と抑うつ発症には調整要因に独立した正の関連が認められた。</p>

    DOI: 10.24802/tpha.2024-07

    Open Access

    CiNii Research

  3. 都市部職域コホートにおける危険因子の集積と心血管疾患発症リスクとの関連及びその集団寄与危険割合

    田島 里菜, 宋 澤安, 洪 英在, 福田 知里, 史 旭良, 吉田 裕子, 清水 宏子, 村上 美晴, 小林 芽生, 中野 嘉久, 松永 眞章, 太田 充彦, 玉腰 浩司, 八谷 寛

    日本循環器病予防学会誌   60 巻 ( 1 ) 頁: 64 - 73   2025年2月

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    記述言語:日本語   出版者・発行元:一般社団法人 日本循環器病予防学会  

    <p>【目的】心血管疾患 (冠動脈疾患及び脳卒中) の発症予防のために、我が国では腹部肥満の存在を必須とするメタボリックシンドロームに着目した特定健診・特定保健指導が実施されている。しかし、非肥満者であっても危険因子の存在や集積が心血管疾患発症リスクとなり、日本人ではその割合が大きいことから、非肥満者で危険因子を有する者への保健指導実施の必要性が指摘されている。肥満の有無による危険因子集積数と心血管疾患発症との関連については、地方住民を対象とした研究が多く、都市部職域勤労者を対象とした研究は少ない。そこで本研究は都市部の自治体職員を対象とする愛知職域コホート研究において、危険因子とその集積数による心血管疾患発症リスク及び集団寄与危険割合 (PAF) を肥満の有無別に推定することを目的とした。</p><p>【方法】2002~08年をベースラインとする愛知職域コホート研究対象者の内、心血管疾患・がん既往のある者、血圧・血糖・脂質・肥満度・蛋白尿・喫煙に欠損のある者、追跡期間1年未満の者を除外した7,179人を対象とした。高血圧 (収縮期血圧≧140 mmHgかつ/又は拡張期血圧≧90 mmHg、又は高血圧治療者)、糖尿病 (空腹時血糖≧126 mg/dL又はHbA1c≧6.5%、又は糖尿病治療者)、高LDLコレステロール血症 (LDLコレステロール≧140 mg/dL又は脂質異常症治療者)、腎臓病 (尿蛋白±以上、又は腎臓病治療者)、現喫煙の5つの危険因子の保有数 (0、1、2、≧3) により4群に分け、心血管疾患発症との関連について多変量調整Cox比例ハザードモデルによるハザード比 (HR) と人口寄与危険度割合 (PAF) を推定した。</p><p>【結果】追跡期間中の心血管疾患発症者数は99名 (非肥満群66名、肥満群33名) であった。非肥満者で危険因子を有さない群と比較し、非肥満者で危険因子1個の群 (HR: 2.43, 95%CI: 1.14-5.21)、2個の群 (HR: 3.96, 95%CI: 1.79-8.74)、3個以上の群 (HR: 4.75, 95%CI: 1.73-13.0)、肥満者で危険因子1個の群 (HR: 4.31, 95%CI: 1.85-10.00)、2個の群 (HR: 3.75, 95%CI: 1.47-9.57)、3個以上の群 (HR: 7.53, 95%CI: 2.86-19.8) における心血管疾患発症リスクは有意に高かった。PAFは、非肥満者で危険因子1個の群、2個の群、3個以上の群でそれぞれ16.7%、16.6%、5.6%、肥満者の危険因子1個の群、2個の群、3個以上の群でそれぞれ10.9%、6.7%、7.0%でいずれも有意であった。</p><p>【結論】肥満の有無によらず危険因子が集積するほど心血管疾患発症リスクは高くなった。危険因子2個以上の集積によるPAFの合計は非肥満群で22.2%、肥満群で13.7%であった。</p>

    DOI: 10.11381/jjcdp.60.1_64

    CiNii Research

  4. Association of Adipose Tissue Insulin Resistance with Risk of Diabetes Incidents in Middleaged Japanese Workers according to BMI states: 17 years of Follow-up of Aichi Worker's Cohort study Open Access

    Akter, T; Song, Z; Takada, M; Hamrah, MH; Wang, S; Endale, BT; Paththamesthrige, SEP; Khine, MT; Matsunaga, M; Ota, A; Tamakoshi, K; Yatsuya, H

    Journal of Epidemiology   advpub 巻 ( 0 )   2025年

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    記述言語:英語   出版者・発行元:日本疫学会  

    DOI: 10.2188/jea.je20250025

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    PubMed

    CiNii Research

  5. Nonrestorative Sleep and Type 2 Diabetes Incidence: the Aichi Workers' Cohort Study Open Access

    Lin, JY; Song, Z; Li, YY; Chiang, CF; Hirakawa, Y; Nakano, Y; Hong, YJ; Matsunaga, M; Ota, A; Tamakoshi, K; Yatsuya, H

    Journal of Epidemiology   34 巻 ( 9 ) 頁: 428 - 433   2024年9月

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    記述言語:英語   出版者・発行元:日本疫学会  

    Background: The term “nonrestorative sleep (NRS)” refers to an unrefreshed feeling at wake-up and is a domain of poor sleep quality. Previous research has demonstrated that NRS is linked to a number of diseases and adverse health outcomes, but less is known regarding the link between NRS and diabetes, particularly in Japanese. Methods: We studied 3,665 middle-aged male participants of the Aichi Workers’ Cohort Study who were followed-up from 2002 through 2019. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) of incident type 2 diabetes mellitus (T2DM) in relation to NRS adjusted for potential confounding variables. Results: During a median follow-up of 14.6 years, 421 type 2 diabetes cases were identified. Participants with NRS had a higher crude incidence rate of T2DM (11.2/1,000 person-years), compared to participants without NRS (9.3/1,000 person-years). In the fully adjusted model, individuals who reported having NRS had a significantly higher risk of developing T2DM (HR1.36; 95% CI, 1.10–1.67). The association was observed only in participants under 50 years old (HR 1.82; 95% CI, 1.36–2.43), not in the older (50 years or older) participants (P for interaction = 0.025). In contrast, stratified analyses by the presence of shift work, obesity, or sleep duration showed similar associations in all the strata. Conclusion: NRS was associated with higher risk of T2DM in middle-aged Japanese male workers independent of a variety of lifestyle factors and other sleep problems.

    DOI: 10.2188/jea.je20230184

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  6. Association between milk consumption in middle age and frailty in later life: The Aichi Workers' cohort study Open Access

    Hong, YJ; Otsuka, R; Song, Z; Fukuda, C; Tajima, R; Lin, JY; Hibino, M; Kobayashi, M; He, YP; Matsunaga, M; Ota, A; Nakano, Y; Li, YY; Tamakoshi, K; Yatsuya, H

    GERIATRICS & GERONTOLOGY INTERNATIONAL   24 巻 ( 7 ) 頁: 700 - 705   2024年7月

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    記述言語:英語   出版者・発行元:Geriatrics and Gerontology International  

    Aim: Several studies have shown that dairy consumption in old age is effective in preventing frailty. However, there is a lack of evidence regarding the association between milk consumption during middle age and the development of frailty in old age. Therefore, we carried out an investigation to explore the association between milk consumption during middle age and development of frailty examined after over 15 years of follow up in a long-term cohort study in Japan. Methods: We studied 265 participants aged 60–79 years (212 men and 53 women) in 2018, who participated in both the baseline survey in 2002 and the frailty assessment in 2018. The amount of milk consumption (g/day) at baseline was age- and energy-adjusted, and classified into three categories (no, low and high consumption: 0 g/day, ≤135.86 g/day, >135.86 g/day in men and 0 g/day, ≤126.44 g/day, >126.44 g/day in women). Odds ratios (OR) and 95% confidence intervals (CI) for prefrailty/frailty after adjusting for lifestyles at baseline, stratified by sex, were estimated using logistic regression analysis. Results: The prevalence of prefrailty/frailty in 2018 was 37.7% and 28.3% in men and women, respectively. Milk consumption categories were inversely associated with the prevalence of prefrailty/frailty in men (OR 0.34, 95% CI 0.14–0.84 in low consumption; OR 0.31, 95% CI 0.10–0.95 in high consumption; P < 0.05), but not in women (OR 0.53, 95% CI 0.11–2.65; P = 0.44). Conclusions: In this study, milk intake in middle-aged men was inversely associated with the prevalence of prefrailty/frailty later in life. Geriatr Gerontol Int 2024; 24: 700–705.

    DOI: 10.1111/ggi.14916

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  7. Associations of overweight and obesity with the risk of cardiovascular disease according to metabolic risk factors among middle-aged Japanese workers: The Aichi Workers’ cohort study Open Access

    Al-shoaibi A.A.A., Li Y., Song Z., Hong Y.J., Chiang C., Nakano Y., Hirakawa Y., Matsunaga M., Ota A., Tamakoshi K., Yatsuya H.

    Obesity Research and Clinical Practice   18 巻 ( 2 ) 頁: 101 - 108   2024年3月

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    記述言語:英語   出版者・発行元:Obesity Research and Clinical Practice  

    Background: The association between obesity and cardiovascular disease (CVD) remains unclear, particularly for those with established CVD risk factors. We analyzed follow-up data from the Aichi Workers’ Cohort Study. We studied the association between the degree of obesity and risk of CVD and its subtypes specifically among individuals with hypertension, hyper-low-density lipoprotein (LDL)-cholesterolemia, or diabetes. Methods: Pooled data of 8972 adults (7076 men and 1896 women) who were recruited between 2002 and 2008 were used in the current analysis. We used multivariable Cox proportional hazard model to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between the degree of obesity assessed with body mass index (BMI) and the risk of CVD and its subtypes, i.e., coronary heart disease (CHD) and stroke. Results: During a median of 12 years, there were 197 CVDs (80 CHDs and 117 strokes). BMI ≥ 27.5 compared to 21.0–22.9 kg/m<sup>2</sup> was positively and significantly associated with the risks of CVD, CHD, and total stroke. Hypertension, hyper-LDL-cholesterolemia, and diabetes mediated 15.9%, 5.8%, and 8.7% of obesity-CVD associations, respectively, and 28.3% by their combination. In the stratified analyses by the presence of risk factors, BMI ≥ 25.0 (overweight/obesity) compared to BMI < 25 kg/m<sup>2</sup> was associated with a higher risk of CVD in those with and without hypertension, but only with hyper-LDL-cholesterolemia, and without diabetes. Conclusions: Overweight/obesity was associated with the risk of CVD and its subtypes. About 30% of the risk was explained by hypertension, hyper-LDL-cholesterolemia, and diabetes, of which hypertension accounted for approximately the half of the explained risk. However, overweight/obesity increased the risk of CVD even in those without hypertension. These findings highlight the importance of controlling and preventing overweight/obesity regardless of chronic disease status.

    DOI: 10.1016/j.orcp.2024.02.006

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  8. Association of psychological factors with advanced-level functional competency: Findings from the Aichi workers' cohort study, 2002-2019 Open Access

    Saif-Ur-Rahman, K; Hong, YJ; Li, YY; Matsunaga, M; Song, Z; Shimoda, M; Al-Shoaibi, A; He, YP; Mamun, MR; Hirano, Y; Chiang, CF; Hirakawa, Y; Aoyama, A; Tamakoshi, K; Ota, A; Otsuka, R; Yatsuya, H

    HELIYON   9 巻 ( 11 ) 頁: e21931   2023年11月

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    記述言語:英語   出版者・発行元:Heliyon  

    Objective: This study examined the longitudinal association of perceived stress, ikigai, and having someone one can count on in middle age with the advanced-level functional competency in older age, which is crucial for the maintenance of independent life among older adults. The issue is especially relevant in super-aged countries like contemporary Japan, where more and more older people live in a household consisting only of older people. Methods: Data were collected in 2019 from a total of 1692 retirees of the Aichi Workers’ Cohort Study participants in which baseline survey including psychological factors was conducted during their employment in 2002. Japan Science and Technology Agency Index of Competence (JST-IC) was used to measure the advanced-level functional competency. Multivariable-adjusted odds ratios (ORs) were obtained for having low JST-IC in later life by the degrees of psychological factors reported in the middle age adjusting for the presence of depressive mood in 2019. Results: Those who were not sure about ikigai (OR: 2.02, 95 % CI: 1.33 to 3.08) and who have no one to count on (OR: 2.19, 95 % CI: 1.52 to 3.16) in the middle age were significantly associated with low JST-IC after retirement. Having much stress was significantly inversely associated with a low JST-IC (OR: 0.69, 95 % CI: 0.50 to 0.97). Conclusion: Having ikigai and someone reliable, and stress during middle age might play a role in preventing impaired advanced-level functional competency. Improved ikigai and increased social interaction and support might improve functional competency. Further research might explore avenues for improving ikigai.

    DOI: 10.1016/j.heliyon.2023.e21931

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  9. Good death for people living with dementia: a qualitative study Open Access

    Mamun, MR; Hirakawa, Y; Saif-Ur-Rahman, KM; Hong, YJ; Song, Z; Yoshida, Y; Yatsuya, H

    BMC GERIATRICS   23 巻 ( 1 ) 頁: 665   2023年10月

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    記述言語:英語   出版者・発行元:BMC Geriatrics  

    Background: Ensuring a good death is one of the primary objectives of palliative care and end-of-life care. There is insufficient evidence regarding what defines a good death for people living with dementia. Obtaining an understanding of what constitutes a good death could help improve dementia care. This study aimed to explore how multiple stakeholders perceive a good death for people living with dementia. Methods: This qualitative study was carried out across six prefectures in Japan. Enrollment of participants took place within dementia outpatient clinics, hospitals, daycare centers, and community centers. A total of thirty-three in-depth interviews with people living with dementia, physicians, and nurses were conducted. Six focus group discussions were performed with family caregivers and care workers. Verbatim transcripts of the interviews were prepared, and inductive content analysis was used to examine the data. Findings: Regarding the perception of a good death, the following themes were derived: (1) painless death; (2) dying in a preferred environment; (3) family’s coping with loss; (4) maintaining regular life; (5) living with respect; and (6) preparation for death. All these themes are interrelated. Participants viewed a good death as a process rather than a single event. Conclusion: This study identifies crucial components of a good death for people living with dementia. The findings could be used to improve dementia care.

    DOI: 10.1186/s12877-023-04395-y

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  10. Current Status of Low-Density Lipoprotein Cholesterol and Cardiovascular Diseases in Japan Open Access

    Al-Shoaibi, AAA; Li, YY; Song, Z; Chiang, CF; Hirakawa, Y; Saif-Ur-Rahman, KM; Shimoda, M; Nakano, Y; Matsunaga, M; Aoyama, A; Tamakoshi, K; Ota, A; Yatsuya, H

    Journal of Atherosclerosis and Thrombosis   30 巻 ( 5 ) 頁: 455 - 466   2023年5月

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    記述言語:英語   出版者・発行元:一般社団法人 日本動脈硬化学会  

    Aims: The associations between low-density lipoprotein cholesterol (LDL-C) and the risk of cardiovascular disease (CVD) subtypes are not well established among the Japanese population. This study used longitudinal data from the Aichi Workers’ Cohort Study to explore the association between LDL-C levels and the risk of coronary heart disease (CHD) and stroke subtypes. Methods: Pooled data of 8966 adults (7093men and 1903 women) who were recruited between (2002) and (2008) were used for the current analysis. Propensity scores for the LDL-C categories were generated using multinomial logistic regression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from the inverse probability weighted Cox proportional hazards model for LDL-C category associations with risks of CHD, stroke subtypes, and CVD. Results: During a median follow-up of 12 years, 122 strokes (57 ischemic strokes, 25 intracerebral hemorrhage, and 40 unknown subtypes) and 82 cases of CHD were observed. LDL-C 160– mg/dL compared to LDL-C 100– 119 mg/dL was positively and significantly associated with the risk of CHD (HR: 4.56; 95% CI: 1.91–10.9) but not with ischemic stroke (HR: 0.99; 95% CI: 0.44–2.22). LDL-C was inversely associated with the risk of intracerebral hemorrhage (P for trend=0.009). Conclusion: In middle-aged Japanese workers, LDL-C was significantly and positively associated with CHD, but not with ischemic stroke. LDL-C was inversely significantly associated with intracerebral hemorrhage.

    DOI: 10.5551/jat.63519

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  11. Long-term variability and change trend of systolic blood pressure and risk of type 2 diabetes mellitus in middle-aged Japanese individuals: findings of the Aichi Workers' Cohort Study

    Song, ZA; He, YP; Chiang, CF; Al-Shoaibi, AAA; Saif-Ur-Rahman, KM; Mamun, MR; Aoyama, A; Hirakawa, Y; Matsunaga, M; Ota, A; Tamakoshi, K; Li, YY; Yatsuya, H

    HYPERTENSION RESEARCH   45 巻 ( 11 ) 頁: 1772 - 1780   2022年11月

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    記述言語:英語   出版者・発行元:Hypertension Research  

    Studies have reported that short-term blood pressure (BP) variability (BPV) is associated with type 2 diabetes mellitus (T2DM) incidence, but the association with long-term BPV remains unclear. The present study investigated the associations of long-term BPV as well as the time trend of BP changes over time with the incidence of T2DM. This study followed a cohort of 3017 Japanese individuals (2446 male, 571 female) aged 36–65 years from 2007 through March 31, 2019. The root-mean-square error (RMSE) and the slope of systolic BP (SBP) change regressed on year were calculated individually using SBP values obtained from 2003 to baseline (2007). A multivariable Cox proportional hazard model was applied to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for tertiles of SBP RMSE and continuous SBP slopes adjusted for age, sex, smoking status, regular exercise, sodium intake, family history of diabetes, sleep disorder, body mass index (BMI), SBP, and fasting blood glucose (FBG) at baseline, and BMI slope from 2003 to 2007. The highest RMSE tertile compared to the lowest was associated with a significantly higher incidence of T2DM after adjusting for covariates (HR: 1.79, 95% CI: 1.15, 2.78). The slope was also significantly associated with T2DM incidence until baseline SBP and FBG were adjusted (HR: 1.03, 95% CI: 0.99, 1.07). In conclusion, long-term SBP variability was significantly associated with an increased incidence of T2DM independent of baseline age, sex, BMI, SBP, FBG, lifestyle factors and BMI slope from 2003 until baseline.

    DOI: 10.1038/s41440-022-00993-2

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▼全件表示

講演・口頭発表等 17

  1. Measures of Long-Term Systolic Blood Pressure Variability and Their Associations with The Risk of Type 2 Diabetes Mellitus.

    International Society of Hypertension 2022 

  2. 日本人中年労働者の職業ストレスと心血管疾患発症の関連:愛知職域コホート研究

    第97回日本産業衛生学会 

  3. Fatigue is Associated with Future Development of Cardiovascular Disease in Middle-age Japanese Workers: findings of Aichi Workers Cohort Study.

  4. 長期血圧変動指標による2型糖尿病発症予測能の変化。

    第7回日本糖尿病・生活習慣病ヒューマンデータ学会年次学術集会 

  5. Long-Term Variability and Change Trend of Systolic Blood Pressure and Risk of Type 2 Diabetes Mellitus in Middle-Aged Japanese.

  6. Association of Presence of Non-Specific Physical Complaints with Future Development of Cardiovascular Disease in Middle-Aged Japanese Workers: Finding From the Aichi Workers Cohort Study. 国際会議

    American Heart Association EPI:LIFESTYLE 2024 

  7. Predictive Value Of Long-term Systolic Blood Pressure Variability For The Development Of Type 2 Diabetes Mellitus. 国際会議

    American Heart Association EPI: LIFESTYLE 2023 

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    記述言語:英語   会議種別:口頭発表(一般)  

  8. 20歳から中年期までの体重変化は、中年期から老年期までの体重変化から独立したフレイル発症関連要因である。

    第7回日本糖尿病・生活習慣病ヒューマンデータ学会年次学術集会 

  9. "Association of Adipocyte Insulin Resistance with Risk of Diabetes Incidents in Japanese Workers"

  10. 朝食欠食と抑うつ発症の関連:愛知職域コホート研究

    第97回日本産業衛生学会 

  11. Obesity is Associated With High Medical Costs in Japanese Patients with Hypertension

  12. "20歳代の体重増加はフレイル発症関連要因である―愛 知職域コホート研究"

    第33回日本疫学会学術集会 

  13. Cross-sectional association between fasting blood glucose and chewing difficulty

  14. 肥満の有無の心血管危険因子集積数と心血管疾患発症リスク及び集団寄与危険割合:愛知職域コホート研究

    第59回日本循環器病予防学会学術集会 

  15. Non-restorative Sleep and Diabetes incidence: the Aichi Workers' Cohort Study.

  16. 中年期の牛乳摂取と老年期フレイル発症の関連.

    第68回東海公衆衛生学会学術大会 

  17. Association of low-density lipoprotein cholesterol with risk of coronary heart disease and stroke among middle-aged Japanese workers: An analysis using inverse probability weighting 国際会議

    American Heart Association EPI: LIFESTYLE 2022 

     詳細を見る

    記述言語:英語  

▼全件表示

科研費 2

  1. 経年的なストレス及び健診情報による高齢期認知機能低下や活動能力の予測モデル開発

    研究課題/研究課題番号:24K23643  2024年7月 - 2026年3月

    科学研究費助成事業  研究活動スタート支援

    宋 澤安

      詳細を見る

    担当区分:研究代表者 

    配分額:2730000円 ( 直接経費:2100000円 、 間接経費:630000円 )

    本研究は、中年期におけるストレスの経年変化と老年期における認知症発症との関係を解明し、老年期の活動能力や生活の質に影響を与える中年期のリスク因子を探索することを目的としている。また、予測モデルの開発を通じて、高齢者の生活の質と心身の健康状態を向上させることを目指す。

  2. コロナ禍での持病悪化要因と持病有無が就労関連要因の心血管発症リスクに及ぼす影響

    研究課題/研究課題番号:23K24607  2022年4月 - 2027年3月

    科学研究費助成事業  基盤研究(B)

    八谷 寛, 大塚 礼, 李 媛英, 玉腰 浩司, 太田 充彦, 山田 宏哉, 松永 眞章, 高田 碧, 宋 澤安, 中野 嘉久, 平川 仁尚, 江 啓発

      詳細を見る

    担当区分:研究分担者 

    長期間追跡調査である愛知職域コホート研究において、就労関連要因と心血管疾患発症との関連が高血圧や糖尿病といった危険因子(持病)の有無によって異なるかを検討する。追跡調査と生活習慣等の繰り返し調査により、自覚ストレスや職場ストレッサーと持病との関連を検討し、コロナ禍等の環境変化の影響を考察する。データベースの統計解析とともに、他の職域コホートとのデータ統合研究を行う準備を行う。
    本研究は、申請者らが長期間追跡調査を実施している愛知職域コホート研究において、労働時間、職場ストレス、勤務形態などの労働に関係した要因と心血管疾患発症との関連を高血圧や糖尿病といった危険因子の有無によって層別化して検討を行うこと、追跡調査と生活習慣等の繰り返し調査を同コホート研究で実施し縦断的に把握した自覚ストレス、仕事の要求度-コントロールモデルに基づく職場ストレスと、持病に関する変数の変化との関連を検討し、コロナ禍の影響を考察することを目的としている。研究計画にしたがって、2023(令和6)年度は、生活習慣や健康状態の繰り返し質問紙調査である第6次コホートベースライン調査を実施し、生活習慣アンケート(n=5,303)のデータベース構築を進めた。また血液保存には4,799名の協力同意が得られた。対象者の自己申告体重、身長から計算したbody mass indexの平均値は男性23.0 kg/m2、女性21.3 kg/m2、現喫煙者は男性7.8%、女性1.1%、飲酒する者は男性67.5%、女性53.0%、食物摂取頻度調査法から推定した食塩摂取量は男性10.7 g、女性9.1 gであった。また、病歴スクリーニングのための自己申告調査とデータベース化、病歴の詳細に関する診療録調査の準備、症例定義の検討、対象職域を通した発症把握、経年的健診成績の把握等を実施した。さらに、第5回調査までの既存調査結果、追跡情報を用いて、統計解析を実施した。具体的には、心理的状態と退職後の高齢者活動能力指標との関連、目覚めた時にすっきりしないことと2型糖尿病発症の関連、肥満度と心血管疾患発症リスクの関連を公表した。
    生活習慣等の繰り返し調査、追跡調査、統計解析、外部公開データベース活用の準備のいずれも概ね計画通り進んでいる。
    職域コホートの対象職域を退職した対象者に対する生活習慣等に関する調査の実施、追跡調査の継続的実施、第6次ベースライン調査データベースの整備と集計、血液検体の保存と解析、持病の有無により層化して、継続的に調査しているストレスや主観的健康観、さらに職場要因等の心血管疾患発症との関連性を検討する統計解析の実施などを行っていく。