Updated on 2026/03/20

写真a

 
YUAN Xunmei
 
Organization
Research Institute of Environmental Medicine Division of Stress Recognition and Response Designated Assistant Professor
Title
Designated Assistant Professor

Degree 1

  1. 博士（理学） （ 1999.12   東京工業大学 ） 

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Research Interests 1

  1. Chronic inflammation, Epigenome

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Research Areas 2

  1. Life Science / Molecular biology

  2. Life Science / Pathobiochemistry

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Education 1

  1. Tokyo Institute of Technology

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Papers 14

  1. Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood Reviewed Open Access

    Yuan X†, Tsujimoto K†, Hashimoto K, Kawahori K, Hanzawa N, Hamaguchi M, Seki T, NawaM, Ehara T, Kitamura Y, Hatada I, Konishi M, Itoh N, Nakagawa Y, Shimano H,Takai-Igarashi T, Kamei Y & Ogawa Y

    Nat Commun   Vol. 9   page： 636   2018.2

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    Authorship：Lead author  

    DOI： 10.1038/s41467-018-03038-w

    Open Access

  2. Altered glycolipid metabolism during acute kidney injury exacerbates renal inflammation Reviewed International journal Open Access

    Osada, A; Tanaka, M; Sugiura, Y; Yuan, XM; Yamashita, S; Ochi, K; Kohda, H; Ito, A; Go, S; Okajima, T; Kadomatsu, K; Yanagita, M; Furuhashi, K; Maruyama, S; Suganami, T

    SCIENTIFIC REPORTS   Vol. 16 ( 1 ) page： 147   2025.12

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    Language：English   Publisher：Scientific Reports  

    Acute kidney injury (AKI) can progress to chronic kidney disease (CKD), via a mechanism that is still largely unknown. We previously reported that glucosylceramide (GlcCer) acts as a damage-associated molecular pattern (DAMP) during AKI. Here, we demonstrate that renal GlcCer levels increase persistently during AKI, primarily due to oxidative stress-mediated downregulation of β-1,4-galactosyltransferase 5 (B4galt5) in proximal tubules. Using mass spectrometry, we showed that GlcCer specifically accumulated in damaged proximal tubules. Among the enzymes involved in GlcCer metabolism, B4galt5 was predominantly expressed in proximal tubules and its expression was consistently downregulated across multiple AKI models. Knockdown of B4galt5 alone was sufficient to increase GlcCer levels in cultured proximal tubular cells. Moreover, in vivo administration of GlcCer combined with free cholesterol triggered inflammatory responses via the innate immune receptor macrophage-inducible C-type lectin (Mincle). These inflammatory responses were almost abolished in Mincle-deficient mice, suggesting a specific GlcCer-Mincle pathway. Our findings indicate that B4galt5 plays a critical role in GlcCer accumulation in necrotic tubules following AKI. Specifically, we propose that dying proximal tubules alter their glycolipid metabolism to generate DAMPs, highlighting B4galt5 as a potential therapeutic target for preventing the AKI-to-CKD transition.

    DOI： 10.1038/s41598-025-28897-4

    Open Access

    Web of Science

    Scopus

    PubMed

  3. Novel Cell-to-Cell Communications Between Macrophages and Fibroblasts Regulate Obesity-Induced Adipose Tissue Fibrosis Reviewed Open Access

    H. Kohda, M. Tanaka, S. Shichino, S. Arakawa, T. Komori, A. Ito, E. Wada, K. Ochi, X. Yuan, T. Takeda, A. Saiki, I. Tatsuno, K. Ikeda, Y. Miyai, A. Enomoto, Y. Morikawa, S. Shimizu, S. Ueha, K. Matsushima, Y. Ogawa, T. Suganami.

    Diabetes   Vol. 74   page： 1135 - 1152   2025

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2337/db24-0762

  4. Interleukin-4 induced 1-mediated resistance to an immune checkpoint inhibitor through suppression of CD8+ T cell infiltration in melanoma Reviewed Open Access

    Shiho Hirose, Tetsuo Mashima, Xunmei Yuan, Makiko Yamashita, Shigehisa Kitano, Shinichi Torii, Toshiro Migita, and Hiroyuki Seimiya

    Cancer Science   Vol. 115   page： 971   2024.3

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  5. APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells Reviewed

      Vol. 135   page： 101   2024.1

  6. Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver Reviewed Open Access

    Kawahori K, Kondo Y, Yuan X, Kawasaki Y, Hanzawa N, Tsujimoto K, Wada F, Kohda T, Ishigami A, Yamada T, Ogawa Y, Hashimoto K

    Sci Rep   Vol. 10   page： 21228   2020.12

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  7. Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing Reviewed Open Access

    Hanzawa N, Hashimoto K, Yuan X, Kawahori K, Tsujimoto K, Hamaguchi M, Tanaka T, Nagaoka Y, Nishina H, Morita S, Hatada I, Yamada T, Ogawa Y

    Sci Rep   Vol. 10   page： 5181   2020.3

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  8. Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis Reviewed Open Access

    M. Asakawa, M. Itoh, *T. Suganami, T. Sakai, S. Kanai, I. Shirakawa, X. Yuan, T. Hatayama, S. Shimada, Y. Akiyama, K. Fujiu, Y. Inagaki, I. Manabe, S. Yamaoka, T. Yamada, S. Tanaka, Y. Ogawa

    Sci Rep   Vol. 9   page： 19601   2019.12

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  9. Mild Maternal Hypothyroxinemia During Pregnancy Induces Persistent DNA Hypermethylation in the Hippocampal Brain-Derived Neurotrophic Factor Gene in Mouse Offspring Reviewed

    Kawahori K, Hashimoto K, Yuan X, Tsujimoto K, Hanzawa N, Hamaguchi M, Kase S,Fujita K, Tagawa K, Okazawa H, Nakajima Y, Shibusawa N, Yamada M, Ogawa Y

    Thyroid   Vol. 28   page： 395   2018.3

  10. Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver Reviewed

    Ehara T, Kamei Y, Takahashi M, Yuan X, Kanai S, Tamura E, Tanaka M, Yamazaki T,Miura S, Ezaki O, Suganami T, Okano M, Ogawa Y

    Diabetes   Vol. 64   page： 775   2015.3

  11. Analysis of DNA methylation change induced by Dnmt3b in mouse hepatocytes Invited Reviewed

    Takahashi M, Kamei Y, Ehara T, Yuan X, Suganami T, Takai-Igarashi T, HatadaI, Ogawa Y:, Kamei Y, Yuan X, Ogawa Y

    Biochem Biophys Res Commun   Vol. 434   page： 873   2013.4

  12. Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver Reviewed

    Ehara T, Kamei Y, Yuan X, Takahashi M, Kanai S, Tamura E, Tsujimotol K, TamiyaT, Nakagawa Y, Shimano H, Takai-Igarashi T, Hatada I, Suganami T, Hashimoto K, Ogawa Y

    Diabetes   Vol. 61   page： 2442   2012.10

  13. Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated Fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue Reviewed

    Suganami T, Yuan X, Shimoda Y, Uchio-Yamada K, Nakagawa K, Shirakawa I, Usami T,Tsukahara T, Nakayama K, Miyamoto Y, Yasuda K, Matsuda J, Kamei Y, Kitajima N and Ogawa Y.

    Circ Res   Vol. 105   page： 25   2009.7

  14. Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages Reviewed Open Access

    Suganami T, Tanimoto-Koyama K, Nishida J, Itoh M, Yuan X, Mizuarai S, Kotani H, Yamaoka S, Miyake K, Aoe S, Kamei Y, Ogawa Y.

    Arterioscler Thromb Vasc Biol   Vol. 27   page： 84   2007.1

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Presentations 1

  1. Molecular Mechanism and Physiological Meaning of Epigenetic Regulation of FGF21 Gene Invited International conference

    Xunmei Yuan

    2019.12 

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    Event date： 2019.12

    Language：English   Presentation type：Symposium, workshop panel (nominated)  

    Country：Japan  

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KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. Molecular mechanism and functional meaning of PPARalpha-dependent DNA demethylation of FGF21 gene

    2017.4 - 2020.3

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    Authorship：Principal investigator 

  2. Analysis of epigenetic memory of FGF21 gene in the liver

    2014.4 - 2017.3

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    Authorship：Principal investigator 

To the head of KAKENHI (Grants-in-Aid for Scientific Research).▲