Updated on 2025/10/24

写真a

 
FUKAYA Ryota
 
Organization
Graduate School of Medicine Center for Research of Laboratory Animals and Medical Research Engineering Division for Advanced Medical Research Assistant Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Assistant Professor

Degree 1

  1. 博士（医学） （ 2018.2   名古屋大学 ） 

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Papers 7

  1. Twinfilin-1 phosphorylation in reelin signaling regulates actin dynamics and spine development

    Dong G., Mori D., Matsuzaki T., Tanaka R., Itoh N., Matsui T., Sato A., Arioka Y., Okumura H., Fukaya R., Kuba H., Nagai T., Nabeshima T., Ikesue H., Kohno T., Hattori M., Kaibuchi K., Ozaki N., Mizoguchi H., Yamada K.

    Pharmacological Research   Vol. 221   page： 107986   2025.11

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    Language：English   Publisher：Pharmacological Research  

    Reelin is an extracellular glycoprotein essential for neuronal migration, spine development, and synaptic plasticity. Impaired reelin signaling is linked to neurological disorders, including schizophrenia and autism. While reelin mutant (reeler) mice exhibit behavioral deficits associated with impaired spine formation, the underlying molecular mechanisms remain unclear. We identified Twinfilin-1 (Twf1) as a downstream effector of reelin signaling via phosphoproteomic analysis, based on its reduced tyrosine phosphorylation in reeler mice. We found that Src regulated Twf1 phosphorylation at tyrosine 309, and reelin stimulation increased Twf1 phosphorylation in neurons, an effect blocked by the Src inhibitor PP2. A phospho-resistant Twf1 mutant (Twf1 Y309F) showed reduced capping protein binding and a lower F/G-actin ratio. Twf1<sup>Y309F</sup> mice exhibited cognitive deficits, reduced spine density, smaller spine head size, and a decreased F/G-actin ratio in synaptosomes. These findings highlight Twf1 phosphorylation as a key component of reelin signaling involved in actin remodeling and spine development.

    DOI： 10.1016/j.phrs.2025.107986

    Scopus

    PubMed

  2. Mechanistic insights into cAMP-mediated presynaptic potentiation at hippocampal mossy fiber synapses. Reviewed International coauthorship Open Access

    Fukaya R., Miyano R., Hirai H., & Sakaba T.

    Frontiers in Cellular Neuroscience     2023.7

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fncel.2023.1237589

    Open Access

  3. Increased vesicle fusion competence underlies long-term potentiation at hippocampal mossy fiber synapses. Reviewed International coauthorship

    Fukaya R.#, Hirai H.#, Sakamoto H.#, Hashimotodani Y., Hirose K., & Sakaba T. (# equal contribution)

    Science Advances     2023.2

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  4. Rapid Ca2+ channel accumulation contributes to cAMP-mediated increase in transmission at hippocampal mossy fiber synapses. Reviewed International coauthorship

    Fukaya R.#, Maglione M.#, Sigrist S. J., & Sakaba T. (# equal contribution)

    roceedings of the National Academy of Sciences of the United States of America     2021.3

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  5. Structural and functional refinement of the axon initial segment in avian cochlear nucleus during development. Reviewed Open Access

    Akter N., Fukaya R., Adachi R., Kawabe H., & Kuba H.

    Journal of Neuroscience     2020.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1523/JNEUROSCI.3068-19.2020

  6. Auditory input shapes tonotopic differentiation of Kv1.1 expression in avian cochlear nucleus during late development. Reviewed Open Access

    Akter N., Adachi R., Kato A., Fukaya R., & Kuba H.

    Journal of Neuroscience     2018.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1523/JNEUROSCI.2472-17.2018

    Open Access

  7. Tonotopic variation of the T-type Ca2+ current in avian auditory coincidence detector neurons. Reviewed

    Fukaya R., Yamada R., & Kuba H.

    Journal of Neuroscience     2018.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

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