Updated on 2024/03/22

写真a

 
TAKANO Nao
 
Organization
Nagoya University Hospital Lecturer of hospital
Title
Lecturer of hospital

Degree 1

  1. 医学博士 ( 2017.3   名古屋大学 ) 

Research History 2

  1. Nagoya University   Nagoya University Hospital   Lecturer of hospital

    2023.10

  2. Pharmaceuticals and Medical Devices Agency   Office of New Drug V   Clinical reviewer

    2019.10 - 2023.9

 

Papers 44

  1. Clinical questions and good practice statements of clinical practice guidelines for management of kidney injury during anticancer drug therapy 2022 (oct, 10.1007/s10157-023-02415-0, 2022)

    Yanagita, M; Muto, S; Nishiyama, H; Ando, Y; Hirata, S; Doi, K; Fujiwara, Y; Hanafusa, N; Hatta, T; Hoshino, J; Ichioka, S; Inoue, T; Ishikura, K; Kato, T; Kitamura, H; Kobayashi, Y; Koizumi, Y; Kondoh, C; Matsubara, T; Matsubara, K; Matsumoto, K; Okuda, Y; Okumura, Y; Sakaida, E; Shibagaki, Y; Shimodaira, H; Takano, N; Uchida, A; Yakushijin, K; Yamamoto, T; Yamamoto, K; Yasuda, Y; Oya, M; Okada, H; Nangaku, M; Kashihara, N

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 28 ( 2 ) page: 123 - 124   2024.2

  2. Chapter 3: Management of kidney injury caused by cancer drug therapy, from clinical practice guidelines for the management of kidney injury during anticancer drug therapy 2022

    Ando Yuichi, Nishiyama Hiroyuki, Shimodaira Hideki, Takano Nao, Sakaida Emiko, Matsumoto Koji, Nakanishi Koki, Sakai Hideki, Tsukamoto Shokichi, Komine Keigo, Yasuda Yoshinari, Kato Taigo, Fujiwara Yutaka, Koyama Takafumi, Kitamura Hiroshi, Kuwabara Takashige, Yonezawa Atsushi, Okumura Yuta, Yakushijin Kimikazu, Nozawa Kazuki, Goto Hideaki, Matsubara Takeshi, Hoshino Junichi, Yanagita Motoko

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 28 ( 10 ) page: 1315 - 1332   2023.10

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    Language:English   Publisher:International Journal of Clinical Oncology  

    Cisplatin should be administered with diuretics and Magnesium supplementation under adequate hydration to avoid renal impairment. Patients should be evaluated for eGFR (estimated glomerular filtration rate) during the treatment with pemetrexed, as kidney injury has been reported. Pemetrexed should be administered with caution in patients with a CCr (creatinine clearance) < 45 mL/min. Mesna is used to prevent hemorrhagic cystitis in patients receiving ifosfamide. Febuxostat is effective in avoiding hyperuricemia induced by TLS (tumor lysis syndrome). Preventative rasburicase is recommended in high-risk cases of TLS. Thrombotic microangiopathy could be triggered by anticancer drugs and there is no evidence of efficacy of plasma exchange therapy. When proteinuria occurs during treatment with anti-angiogenic agents or multi-kinase inhibitors, dose reductions or interruptions based on grading should be considered. Grade 3 proteinuria and renal dysfunction require urgent intervention, including drug interruption or withdrawal, and referral to a nephrologist should be considered. The first-line drugs used for blood pressure elevation due to anti-angiogenic agents are ACE (angiotensin-converting enzyme) inhibitors and ARBs (angiotensin receptor blockers). The protein binding of drugs and their pharmacokinetics are considerably altered in patients with hypoalbuminemia. The clearance of rituximab is increased in patients with proteinuria, and the correlation with urinary IgG suggests similar pharmacokinetic changes when using other antibody drugs. AIN (acute interstitial nephritis) is the most common cause of ICI (immune checkpoint inhibitor)-related kidney injury that is often treated with steroids. The need for renal biopsy in patients with kidney injury that occurs during treatment with ICI remains controversial.

    DOI: 10.1007/s10147-023-02382-2

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  3. Successful Conversion Surgery for Unresectable Gastric Cancer with Tumor Thrombus in the Portal Vein

    SUGIYAMA Fumitake, TAKANO Nao, KUWANO Seiya, NONOGAKI Ikue, HOTTA Yoshihiro, HIBI Kenji

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)   Vol. 83 ( 2 ) page: 326 - 330   2022

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    Language:Japanese   Publisher:Japan Surgical Association  

    <p>An 80-year-old man with performance status (PS) 0 who presented with hyperthermia, abdominal pain, and abnormal liver function following a blood examination was diagnosed with type 3 gastric cancer and obstructive cholangitis caused by giant tumor thrombus in the portal vein with obstruction. Biopsy of the gastric tumor yielded a diagnosis of papillary adenocarcinoma with HER2-positive expression. After treatment of cholangitis, he received combination chemotherapy with capecitabine, oxaliplatin, and trastuzumab. After 13 cycles of chemotherapy, the primary tumor was markedly reduced in size, and the portal vein tumor thrombus disappeared. Therefore, total gastrectomy with D2 lymph node dissection as conversion surgery was performed. Operation time was 317 minutes, and blood loss was 324 ml. He was discharged on postoperative day 30 with no complications. S-1 was administered as adjuvant chemotherapy. He is alive without evidence of recurrence 30 months after surgery.</p>

    DOI: 10.3919/jjsa.83.326

    CiNii Research

  4. Association between working overtime and psychological stress reactions in elementary and junior high school teachers in Japan: a large-scale cross-sectional study

    FURIHATA Rika, KUWABARA Miki, OBA Koji, WATANABE Kazuhiro, TAKANO Nao, NAGAMINE Noritoshi, MARUYAMA Yoko, ITO Nobuhiro, WATANABE Izumi, TSUBONO Kenjiro, IKEDA Chikako, SAKAMOTO Junichi

    Industrial Health   Vol. 60 ( 2 ) page: 133 - 145   2021.10

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    Language:English   Publisher:National Institute of Occupational Safety and Health  

    <p>This study aimed to investigate the relationship between working overtime and psychological stress reactions among school teachers. It also evaluated the interaction of overtime work types (on weekdays, on holidays, and bringing work home) and task content (educational, peripheral and both). This cross-sectional study was conducted on Japanese elementary and junior high school teachers. Primary outcome was psychological stress reactions measured with the Brief Job Stress Questionnaire. Participants were asked how long they work overtime on weekdays, holidays, and at home. Participants were also asked whether they engaged in educational tasks and/or peripheral tasks during that overtime work. Multiple linear regression analyses were applied and 6,135 participants were included in the analyses after imputing missing data. Working hours of all three types were significantly correlated with higher psychological stress reactions. Moreover, engaging in both educational and peripheral tasks showed higher psychological stress reactions than in only educational tasks when working overtime on weekdays and holidays. In conclusion, reducing overtime work regardless of work types is crucial for mitigating psychological stress reactions for teachers. It might also be possible to manage the psychological stress reactions by splitting the role of task contents, when working overtime on weekdays and holidays at school.</p>

    DOI: 10.2486/indhealth.2021-0069

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  5. The impact of early tumor shrinkage on conversion surgery and the survival in patients with unresectable locally advanced pancreatic cancer

    Takano Nao, Yamada Suguru, Sonohara Fuminori, Inokawa Yoshikuni, Takami Hideki, Hayashi Masamichi, Koike Masahiko, Fujii Tsutomu, Kodera Yasuhiro

    SURGERY TODAY   Vol. 51 ( 7 ) page: 1099 - 1107   2021.7

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    Language:English   Publisher:Surgery Today  

    Purposes: Owing to recent advances in induction chemo(radio)therapy, patients with unresectable locally advanced pancreatic ductal adenocarcinoma (UR-LA PDAC) are sometimes indicated for conversion surgery (CS). However, the predictors for proceeding to CS are unclear. We investigated the predictive factors for CS, especially at the early stage of induction therapy, and evaluated the impact of CS on the survival. Methods: We analyzed 49 UR-LA PDAC patients retrospectively and investigated the predictive factors for proceeding to CS, including early tumor shrinkage (ETS). ETS in this study was defined as shrinkage of tumors by ≥ 15% at 8–12 weeks after the induction of treatment. Results: CS was performed in 21 patients (43%). In a multivariate logistic regression analysis, ETS was an independent predictive factor for successfully proceeding to CS (P = 0.046). The median overall survival (OS) was not reached in the CS group but was 17.2 months in the non-CS group (P < 0.0001). A multivariate analysis by the Cox proportional hazard model identified CS as the only significant independent determinant of the OS (hazard ratio: 0.26, 95% confidence interval: 0.07–0.94, P = 0.004). Conclusions: ETS by induction therapy is a significant predictor of proceeding to CS among patients with UR-LA PDAC. CS was the only independent prognostic factor for this population.

    DOI: 10.1007/s00595-020-02220-2

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KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. Rapid procedure of quantitative methylation specific pcr for molecular surgical margin analysis.

    Grant number:15K19850  2015.4 - 2017.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    TAKANO Nao, HAYASHI Masamichi, KURIMOTO Keisuke, KANDA Mitsuro

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    Authorship:Principal investigator 

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

    Whether a certain tissue has cancerous potential or not could be diagnosed by the detection of cancer-specific gene aberration. It usually takes a few days to proceed the experiment. Our novel gene methylation detecting assay needs only 2.5 hours with less expensive and reproducible method. This rapid quantitative methylation-specific PCR assay (rapid QMSP) could be performed in intra-operative time setting and diagnose the existence of residual tiny cancerous cells on the surgical site. We think this processing time could be more shorten by unknown novel experimental kits or equipments in the future.