Updated on 2024/03/12


IWASAKI Naruhito
Graduate School of Medicine Program in Integrated Medicine Social Life Science Lecturer
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
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Degree 1

  1. 医学博士 ( 2016.9   滋賀医科大学 ) 

Research Interests 3

  1. 耳鼻咽喉科

  2. 公衆衛生

  3. アレルギー

Research Areas 3

  1. Life Science / Hygiene and public health (laboratory)

  2. Life Science / Connective tissue disease and allergy

  3. Life Science / Otorhinolaryngology

Research History 5

  1. Nagoya University   Lecturer


  2. Northwestern University   Researcher

    2021.10 - 2023.4

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    Country:United States

  3. Osaka City University   Researcher

    2019.4 - 2021.10

  4. Osaka City University   Lecturer of hospital

    2018.4 - 2019.3

  5. Osaka City University

    2016.7 - 2018.3

Education 2

  1. Shiga University of Medical Science   Graduate School of Medicine

    2012.4 - 2016.9

  2. Shiga University of Medical Science   Undergraduate School of Medicine   Faculty of Medicine

    2002.4 - 2008.3

Professional Memberships 4

  1. 日本衛生学会


  3. 日本産業衛生学会


Awards 1

  1. 第13回日本アレルギー学会学術大会賞

    2017.6   日本アレルギー学会   エンドトキシンを引き金としたIgE非依存性鼻炎症状の誘導

    岩﨑 成仁


Papers 12

  1. Beneficial and adverse effects of dam construction in canal tannery wastewater effluent with a high content of chromium in Hazaribagh, Bangladesh. International journal

    Fitri Kurniasari, Maw Than Htike, Akira Tazaki, Takumi Kagawa, M M Aeorangajeb Al Hossain, Anwarul Azim Akhand, Nazmul Ahsan, Shoko Ohnuma, Naruhito Iwasaki, Masashi Kato

    Chemosphere   Vol. 350   page: 141047 - 141047   2024.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Blockage to divide downstream canals into upstream canals, into which tannery wastewater including a high concentration of trivalent chromium [Cr(III)] is directly discharged, has been constructed in Hazaribagh, a tannery built-up area in Bangladesh. However, there has been no study to verify the environmental significance of blockage construction for water pollution of Cr in nature. METHODS: Consecutive fixed area monitoring for a total of 164 water samples collected outside and inside Hazaribagh from 2014 to 2023 was carried out to clarify the effects of stagnant and flowable canal water in the presence or absence of blockage on Cr(III) and hexavalent Cr [Cr(VI)] concentrations. RESULTS: Since pollution of Cr(III) and Cr(VI) in Buriganga River (outside Hazaribagh) was not serious, this study then focused on their pollution in canal water (inside Hazaribagh) in the nonblockage period, blockage construction period and blockage destruction period. As expected, the mean Cr(III) concentration in downstream canal water samples in the blockage construction period was more than 98% lower than that in the upstream canal water samples in the same period, while the concentrations were comparable in downstream and upstream canal water samples in the nonblockage period and blockage destruction period. Unexpectedly, the mean concentration of Cr(VI) in the upstream canal water samples in the blockage construction period was 38.6-fold and 3.3-fold higher than that in the downstream canal water samples and the Cr(VI) guideline value by the US-EPA, respectively. CONCLUSION: This study demonstrated for the first time not only a merit of decreased Cr(III) pollution but also a demerit of increased Cr(VI) pollution in stagnant water derived from blockage construction in natural environments. This bitter lesson obtained by the enclosure of Cr(III)-polluted water is globally applicable for water pollution of Cr(III), which is used in various industries including the leather industry.

    DOI: 10.1016/j.chemosphere.2023.141047


  2. Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice. Reviewed International journal

    Naruhito Iwasaki, Seigo Terawaki, Kouhei Shimizu, Daisuke Oikawa, Hirokazu Sakamoto, Kishiko Sunami, Fuminori Tokunaga

    Inflammation research : official journal of the European Histamine Research Society ... [et al.]   Vol. 70 ( 5 ) page: 539 - 541   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Histamine derived from mast cells and basophils plays important roles in inducing allergic symptoms. Although T cells also produce histamine, the involvement of the histamine produced from T cells has remained enigmatic. We sought to reveal the roles of T helper 2 (Th2) cell-derived histamine in nasal allergic disorders. METHODS: The histamine production from Th2 cells was measured by EIA. The mRNA expression of histidine decarboxylase (HDC) was measured by real-time PCR. To investigate the roles of Th2 cell-derived histamine in vivo, we analyzed an antigen-specific Th2 cell transfer mouse model. RESULTS: Th2 cells produced histamine by T cell receptor stimulation, and these properties were specific for Th2 cells, but not Th1 cells and naïve CD4 T cells. The histamine produced from Th2 cells was involved in the infiltrations of Th2 cells in response to antigen exposure. CONCLUSION: These results suggest that Th2 cell-derived histamine play important roles in nasal allergic disorders.

    DOI: 10.1007/s00011-021-01458-x


  3. Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling. Reviewed International journal

    Naruhito Iwasaki, Seigo Terawaki, Kouhei Shimizu, Daisuke Oikawa, Hirokazu Sakamoto, Kishiko Sunami, Fuminori Tokunaga

    PloS one   Vol. 16 ( 3 ) page: e0248158   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    Histamine, which is mainly produced by mast cells and basophils, participates in various allergic symptoms, and some studies have reported that macrophages also produce histamine. Moreover, recent studies have revealed that macrophages, especially alternatively activated macrophages (M2) induced by T helper 2 (Th2) cytokines, such as interleukin (IL)-4 and IL-13, participate in the pathogenesis of allergic diseases. The major source of Th2 cytokines is antigen-specific Th2 cells. To elucidate the relationship between histamine, macrophages, and Th2 cells in allergic inflammation, we established a macrophage-Th2 cell co-culture model in vitro and an antigen-specific Th2 cell transfer mouse model of rhinitis. In vitro analyses indicated that macrophages produce histamine by interacting with antigen-specific Th2 cells through the antigen. Furthermore, Th2 cells and macrophages cooperatively elicited rhinitis in the mouse model. We determined that histamine induces Th2- and macrophage-elicited sneezing responses through H1 receptor signaling, whereas it induces nasal eosinophil infiltrations through H4 receptor signaling. Collectively, these results indicate a novel histamine production mechanism by macrophages, in which Th2 cells and macrophages cooperatively induce nasal allergic inflammation through histamine signaling.

    DOI: 10.1371/journal.pone.0248158


  4. Th2 細胞とマクロファージによる 新規I型過敏症様反応の形成 Reviewed


    日本薬理学雑誌   Vol. 155 ( 6 ) page: 369 - 374   2020.11

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    Authorship:Lead author  

  5. Safety profile and immunological response of dual sublingual immunotherapy with house dust mite tablet and Japanese cedar pollen tablet Reviewed

    Minoru Gotoh, Kimihiro Okubo, Atsushi Yuta, Yukiko Ogawa, Hitoshi Nagakura, Shigehiro Ueyama, Tomoyo Ueyama, Kayoko Kawashima, Masashi Yamamoto, Shigeharu Fujieda, Masafumi Sakashita, Hirokazu Sakamoto, Naruhito Iwasaki, Eri Mori, Tomonori Endo, Nobuo Ohta, Hiroshi Kitazawa, Mitsuhiro Okano, Mikiya Asako, Masami Takada, Tetsuya Terada, Yuko Inaka, Syuji Yonekura, Tomokazu Matsuoka, Shinya Kaneko, Hiroki Hata, Nagisa Hijikata, Hisataka Tanaka, Keisuke Masuyama, Yoshitaka Okamoto

    Allergology International   Vol. 69 ( 1 ) page: 104 - 110   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    Background: There have been no studies of dual administration of sublingual immunotherapy (SLIT) tablets for perennial and seasonal allergic rhinitis. This trial (JapicCTI-184014) was conducted to investigate the safety profile and immunological response during dual therapy with SQ house dust mite (HDM) and Japanese cedar pollen (JCP) SLIT tablets.Methods: This was a multicenter, open-label, randomized trial of 109 Japanese patients with coexisting HDM and JCP allergic rhinitis who had positive tests for HDM- and JCP specific IgE (>= 0.7 kU/L). Patients were allocated to receive HDM (N = 54) or JCP (N = 55) SLIT tablets alone for 4 weeks followed by 8 weeks of dual therapy with both SLIT tablets administered within 5 min of each other. Adverse events (AEs), adverse drug reactions (ADRs), and serum IgE and IgG4 specific for HDM (Dermatophagoides farinae, Dermatophagoides pteronyssinus) and JCP were recorded.Results: The percentage of subjects with AEs and ADRs was similar between the two groups and between the two periods of monotherapy and dual therapy. Most AEs and ADRs were mild in severity, and no serious events were observed. The most common ADRs were local events in the oral cavity. Levels of IgE and IgG4 specific for HDM (D. farinae, D. pteronyssinus) and JCP were increased after treatment with HDM and JCP SLIT tablets, respectively.Conclusions: Dual therapy with both SLIT tablets administered within 5 min after 4 weeks of monotherapy with HDM or JCP tablet was well tolerated and induced the expected immunological responses. Copyright (C) 2019, Japanese Society of Allergology. Production and hosting by Elsevier B.V.

    DOI: 10.1016/j.alit.2019.07.007

    Web of Science

  6. Activation of group 2 innate lymphoid cells exacerbates and confers corticosteroid resistance to mouse nasal type 2 inflammation Reviewed

    Taiyo Morikawa, Ayumi Fukuoka, Kazufumi Matsushita, Koubun Yasuda, Naruhito Iwasaki, Shoko Akasaki, Shigeharu Fujieda, Tomohiro Yoshimoto

    International Immunology   Vol. 29 ( 5 ) page: 221 - 233   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:OXFORD UNIV PRESS  

    Corticosteroid-resistant ILC2s exacerbate nasal T(h)2 inflammation.Both T(h)2 cells and group 2 innate lymphoid cells (ILC2s) contribute to allergic diseases. However, their exact role and relationship in nasal allergic disorders are unclear. In this study, we investigated the cooperation of T(h)2 cells and ILC2s in a mouse model of nasal allergic disorder. To differentially activate T(h)2 cells and/or ILC2s in nasal mucosa, mice were intra-nasally administered ovalbumin (OVA) antigen, papain, an ILC2-activator, or both for 2 weeks. Epithelial thickness and number of eosinophils in the nasal mucosa were evaluated at 24 h after the final challenge. Intra-nasal administration of OVA and papain preferentially activated T(h)2 cells and ILC2s, respectively, in the nose. Both OVA and papain increased the nasal epithelial thickness and number of eosinophils, and their coadministration significantly enhanced the symptoms. Although T-/B-cell-deficient mice showed severely decreased nasal symptoms induced by OVA or OVA-plus-papain, the mice still showed slight papain-induced nasal symptoms. In ILC2-deficient mice, OVA-plus-papain-induced nasal symptoms were suppressed to the same level as OVA-alone. Similarly, IL-33- and ST2-deficient mice showed decreased OVA-plus-papain-induced nasal symptoms. IL-5 induced eosinophilia only, but IL-13 contributed to both nasal epithelial thickening and eosinophilia induced by OVA-plus-papain. Dexamethasone ameliorated OVA-alone-induced nasal epithelial thickening. However, OVA-plus-papain-induced nasal epithelial thickening was only partially controlled by dexamethasone. These results demonstrate that IL-33/ST2-pathway-mediated ILC2 activation exacerbated T(h)2-cell-induced nasal inflammation by producing IL-13. Although T(h)2-cell-alone-induced nasal inflammation was controlled by corticosteroid treatment, the activation of ILC2s conferred treatment resistance. Therefore, ILC2s and their activators could be therapeutic targets for treatment-refractory nasal allergic disorders.

    DOI: 10.1093/intimm/dxx030

    Web of Science


  7. Allergen endotoxins induce T-cell-dependent and non-IgE-mediated nasal hypersensitivity in mice Reviewed

    Naruhito Iwasaki, Kazufumi Matsushita, Ayumi Fukuoka, Masakiyo Nakahira, Makoto Matsumoto, Shoko Akasaki, Koubun Yasuda, Takeshi Shimizu, Tomohiro Yoshimoto

    Journal of Allergy and Clinical Immunology   Vol. 139 ( 1 ) page: 258 - +   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MOSBY-ELSEVIER  

    Background: Allergen-mediated cross-linking of IgE on mast cells/basophils is a well-recognized trigger for type 1 allergic diseases such as allergic rhinitis (AR). However, allergens may not be the sole trigger for AR, and several allergic-like reactions are induced by non-IgE-mediated mechanisms. Objective: We sought to describe a novel non-IgE-mediated, endotoxin-triggered nasal type-1-hypersensitivity-like reaction in mice.
    Methods: To investigate whether endotoxin affects sneezing responses, mice were intraperitoneally immunized with ovalbumin (OVA), then nasally challenged with endotoxin-free or endotoxin-containing OVA. To investigate the role of T cells and mechanisms of the endotoxin-induced response, mice were adoptively transferred with in vitro-differentiated OVA-specific T(H)2 cells, then nasally challenged with endotoxin-free or endotoxin-containing OVA.
    Results: Endotoxin-containing, but not endotoxin-free, OVA elicited sneezing responses in mice independent from IgE-mediated signaling. OVA-specific T(H)2 cell adoptive transfer to mice demonstrated that local activation of antigen-specific T(H)2 cells was required for the response. The Toll-like receptor 4-myeloid differentiation factor 88 signaling pathway was indispensable for endotoxin-containing OVA-elicited rhinitis. In addition, LPS directly triggered sneezing responses in OVA-specific T(H)2-transferred and nasally endotoxin-free OVA-primed mice. Although antihistamines suppressed sneezing responses, mast-cell/basophil-depleted mice had normal sneezing responses to endotoxin-containing OVA. Clodronate treatment abrogated endotoxin-containing OVA-elicited rhinitis, suggesting the involvement of monocytes/ macrophages in this response.
    Conclusions: Antigen-specific nasal activation of CD4 1 T cells followed by endotoxin exposure induces mast cell/basophilindependent histamine release in the nose that elicits sneezing responses. Thus, environmental or nasal residential bacteria may exacerbate AR symptoms. In addition, this novel phenomenon might explain currently unknown mechanisms in allergic(-like) disorders.

    DOI: 10.1016/j.jaci.2016.03.023

    Web of Science


  8. Endotoxins induce ige-independent nasal hypersensitivity Reviewed

    Naruhito Iwasaki, Tomohiro Yoshimoto

    Japanese Journal of Allergology   Vol. 66 ( 7 ) page: 936 - 944   2017

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    Language:Japanese   Publisher:Japanese Society of Allergology  

    DOI: 10.15036/arerugi.66.936



  9. エンドトキシンを引き金としたIgE非依存性鼻炎症状の誘導 Reviewed

    岩﨑成仁, 善本知広

    アレルギー   Vol. 66 ( 7 ) page: 936 - 944   2017

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    Authorship:Lead author  

  10. Murine allergic rhinitis and nasal T-h2 activation are mediated via TSLP- and IL-33-signaling pathways Reviewed

    Shoko Akasaki, Kazufumi Matsushita, Yukinori Kato, Ayumi Fukuoka, Naruhito Iwasaki, Masakiyo Nakahira, Shigeharu Fujieda, Koubun Yasuda, Tomohiro Yoshimoto

    International Immunology   Vol. 28 ( 2 ) page: 65 - 76   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:OXFORD UNIV PRESS  

    Thymic stromal lymphopoietin (TSLP) and IL-33 are epithelium-derived proallergic cytokines that contribute to allergic diseases. Although the involvement of TSLP in allergic rhinitis (AR) is suggested, the exact role of TSLP in AR is poorly understood. Furthermore, the relative contribution of TSLP and IL-33 in nasal allergic responses has not been described. In this study, we examined the roles of TSLP and IL-33 in AR by analyzing acute and chronic AR models. Acute AR mice were intraperitoneally immunized with ragweed, then intranasally challenged with ragweed pollen for four consecutive days. Chronic AR mice were nasally administrated ragweed pollen on consecutive days for 3 weeks. In both models, TSLP receptor (TSLPR)-deficient mice showed defective sneezing responses and reduced serum ragweed-specific IgE levels compared with wild-type (WT) mice. Analyses of bone-marrow chimeric mice demonstrated that hematopoietic cells were responsible for defective sneezing in TSLPR-deficient mice. In addition, FceRI+-cell-specific TSLPR-deficient mice showed partial but significant reduction in sneezing responses. Of note, T-h2 activation and nasal eosinophilia were comparable between WT and TSLPR-deficient mice. ST2- and IL-33-deficient mice showed defective T-h2 activation and nasal eosinophilia to acute, but not chronic, ragweed exposure. TSLPR and ST2 double-deficient mice showed defective T-h2 activation and nasal eosinophilia even after chronic ragweed exposure. These results demonstrate that TSLPR signaling is critical for the early phase response of AR by controlling the IgE-mast-cell/basophil pathway. The IL-33/ST2 pathway is central to nasal T-h2 activation during acute allergen exposure, but both TSLPR and ST2 contribute to T-h2 responses in chronically allergen-exposed mice.

    DOI: 10.1093/intimm/dxv055

    Web of Science


  11. 先天性嗅覚障害の7例の臨床的検討

    小野 麻友, 小河 孝夫, 入川 直矢, 岩崎 成仁, 加藤 智久, 清水 猛史

    日本味と匂学会誌   Vol. 18 ( 3 ) page: 613 - 616   2011.12

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    Language:Japanese   Publisher:日本味と匂学会  


    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J04102&link_issn=&doc_id=20120213140084&doc_link_id=%2Fcw7jasts%2F2011%2F001803%2F125%2F0613-0616%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcw7jasts%2F2011%2F001803%2F125%2F0613-0616%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  12. 突発性難聴にBPPV様症候を伴った3例

    岩崎 成仁, 神前 英明, 清水 猛史

    耳鼻咽喉科臨床   Vol. 104 ( 11 ) page: 773 - 777   2011.11

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    Language:Japanese   Publisher:耳鼻咽喉科臨床学会  


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  1. Cutting Edge 好酸球

    岩﨑 成仁, 阪本 浩一

    鼻アレルギーフロンティア   Vol. 17 ( 2 ) page: 74 - 76   2017.8

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    Language:Japanese   Publisher:メディカルレビュー社  

    CiNii Books

  2. アレルギー性鼻炎 ここまで解った病態 治療への展望 エンドトキシンを引き金としたIgE非依存性鼻炎症状の誘導

    岩崎 成仁, 松下 一史, 清水 猛史, 善本 知広

    アレルギー   Vol. 65 ( 4-5 ) page: 341 - 341   2016.5

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    Language:Japanese   Publisher:(一社)日本アレルギー学会  

  3. 自然リンパ球

    岩崎 成仁, 善本 知広

    アレルギー   Vol. 65 ( 2 ) page: 141 - 142   2016

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    Language:Japanese   Publisher:一般社団法人 日本アレルギー学会  

    DOI: 10.15036/arerugi.65.141

  4. Local allergic rhinitis

    岩崎 成仁, 善本 知広

    Japanese Journal of Allergology   Vol. 64 ( 10 ) page: 1354 - 1356   2015

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    Language:Japanese   Publisher:一般社団法人 日本アレルギー学会  

  5. 樹状細胞(<シリーズ>アレルギー用語解説)

    岩崎 成仁, 善本 知広

    アレルギー   Vol. 63 ( 10 ) page: 1368 - 1369   2014

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    Language:Japanese   Publisher:一般社団法人 日本アレルギー学会  

    DOI: 10.15036/arerugi.63.1368

  6. PAMPs(<シリーズ>アレルギー用語解説)

    岩崎 成仁, 善本 知広

    アレルギー   Vol. 63 ( 7 ) page: 958 - 960   2014

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    Language:Japanese   Publisher:一般社団法人 日本アレルギー学会  

    DOI: 10.15036/arerugi.63.958

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KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. Novel histamine production mechanism from macrophages

    Grant number:19K17912  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Iwasaki Naruhito

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    Histamine is a crucial allergic inflammatory mediator produced by mast cells and basophils. In this study, we identified a novel histamine production mechanism by the interaction of macrophages and Th2 cells, and also revealed that Th2 cells produced histamine. In addition, animal model demonstrated that Th2 cells and macrophages induced allergic inflammation through histamine signaling.