記述言語：英語   出版者・発行元：Nagoya Journal of Medical Science  

Adenylate cyclase family members have recently received attention as novel therapeutic targets. However, the significance of adenylate cyclase 9 (ADCY9) in breast cancer has not been elucidated. Here, we evaluated ADCY9 expression in breast cancer (BC) cell lines, and polymerase chain reaction array analysis was performed to determine the correlations between ADCY9 expression levels and 84 tumor-associated genes. The association of ADCY9 messenger RNA (mRNA) expression levels in clinical breast cancer specimens with patients’ clinicopathological factors and prognosis was evaluated. The database of cancer cell line showed that estrogen receptor-positive and progesterone receptor-positive cells expressed higher ADCY9 mRNA levels. ADCY9 expression showed positive correlations with several oncogenes, such as TGFB1, CDKN1A, and BAX in the polymerase chain reaction array analysis. We defined the ratio of ADCY9 mRNA expression levels in breast cancer and adjacent noncancerous tissues as the “C/N ratio”. Among 149 patients with BC, estrogen receptor-positive and progesterone receptor-positive patients exhibited higher C/N ratios than estrogen receptor-negative and progesterone receptor-negative patients, respectively. Patients in the lowest C/N ratio quartile experienced shorter prognosis periods. The C/N ratio of ADCY9 was found as an independent prognostic factor for disease-free survival. Thus, ADCY9 expression is high in hormone receptor-positive breast cancer, and its low expression indicates a poor prognosis in patients with breast cancer.

DOI： 10.18999/nagjms.86.4.665

Open Access

Web of Science

Scopus

PubMed

DOI： 10.1016/j.annonc.2024.07.635

Web of Science

記述言語：日本語   出版者・発行元：一般社団法人 日本内分泌外科学会  

<p>甲状腺や副甲状腺に対する頸部手術において，術後出血は初期対応を誤ると致命的な合併症となりうる。頸部のコンパートメントは比較的狭いため，閉創後に皮弁や筋肉・剝離臓器表面や血管断端などから出血をきたすと，コンパートメント内の圧力が上昇し最終的に気道閉塞を引き起こす。その頻度は約0.3～2.2％と報告されており，当科での2019年１月～2023年12月までの直近５年間の頸部手術における後出血頻度は約1.8％であり，いずれも後遺症なく数日後に退院となっている。</p><p>当科では頸部手術後のベッドサイドにラミネート加工された出血時対応プロトコールを常に置き，当科で以前実施した開創時の動画をQRコードの読み取りで閲覧できるようにして当科以外の医師でも初期対応できるよう工夫している。術後出血に対する術前説明は，書面を用いてその文言が書かれた箇所に下線を引くなどして理解の共有を図っており，術直後の家族説明では後出血が発生する可能性について言及している。</p>

DOI： 10.11226/ojjaes.41.3_177

Open Access

CiNii Research

記述言語：英語   出版者・発行元：一般社団法人 日本内分泌学会  

This study aimed to evaluate the impact of periodic neck ultrasonography (US) on postoperative surveillance for locoregional disease control of patients with low-and intermediate-risk papillary thyroid carcinoma (PTC) who underwent total thyroidectomy. This retrospective cohort study included patients with PTC who underwent total thyroidectomy and central neck dissection at our institution between January, 2000 and December, 2016. The patients were divided into two groups: the physical examination (PE) group (follow-up by PE without periodic US) and the US group (follow-up by PE with periodic US). Serum thyroglobulin levels were measured periodically in both groups. Propensity score matching was used to rigorously balance the significant variables and assess the 10-year postoperative outcomes between the groups. Of the 189 patients, 150 were included after matching (75 in each group). There were no significant differences between the two groups in terms of background characteristics. The median follow-up period was 127.9 months. There was no significant difference in locoregional relapse-free survival between the PE and US groups (97.0 vs. 98.7%, p = 0.541). The overall survival was 96.7% and 98.7% in the PE and US groups, respectively, with no significant difference (p = 0.364). This study demonstrated that the addition of periodic US to PE for postoperative surveillance of patients with low-and intermediate-risk PTC who underwent total thyroidectomy did not significantly affect locoregional control.

DOI： 10.1507/endocrj.ej24-0194

Open Access

Web of Science

Scopus

PubMed

CiNii Research

記述言語：日本語   出版者・発行元：一般社団法人 日本内分泌外科学会  

<p>当科においては中リスク甲状腺乳頭癌に対する外科治療方針を2000年以降全摘（TT）＋D3→TT＋両側D1→片葉切除（IL）＋患側D1へde-escalationしてきた。このde-escalationに伴う治療成績を検証することにより中リスク乳頭癌に対する最適な治療方針を検討した。de-escalationしたことにより，未郭清領域である対側の気管周囲リンパ節には約５分の１の症例でリンパ節転移の存在が推測された。しかし，経過観察期間（中央値約６年）において臨床的な再発は患側外側リンパ節の１例であり，生命予後に影響する様な再発はきたしていない。甲状腺全摘を行わないことにより術後放射性ヨウ素治療も行っていないが，予後には影響していないようである。よって，経過観察期間がまだ短いが, 中リスク群に対するIL＋患側D1郭清は妥当な方針と考えられた。</p>

DOI： 10.11226/ojjaes.40.3_140

CiNii Research