2024/10/28 更新

写真a

モリ マサル
森 大
MORI Masaru
所属
未来社会創造機構 量子化学イノベーション研究所 理論・計測部門 特任講師
職名
特任講師
連絡先
メールアドレス
外部リンク

学位 1

  1. 博士(薬学) ( 2010年3月   東北大学 ) 

研究キーワード 3

  1. プロテオミクス

  2. 薬学

  3. 分析化学(質量分析)

 

論文 1

  1. Composition of Minor Ampullate Silk Makes Its Properties Different from Those of Major Ampullate Silk. 国際誌

    Hiroyuki Nakamura, Nobuaki Kono, Masaru Mori, Hiroyasu Masunaga, Keiji Numata, Kazuharu Arakawa

    Biomacromolecules   24 巻 ( 5 ) 頁: 2042 - 2051   2023年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Spider's minor ampullate silk, or MI-silk, exhibits distinct mechanical properties and water resistance compared to its major ampullate counterpart (MA-silk). The principal protein constituent of MI-silk is known as minor ampullate spidroin, or MiSp, and while its sequence has been deciphered and is thought to underlie the differences in properties with MA-silk, the composition of MI-silk and the relationship between its composition and properties remain elusive. In this study, we set out to investigate the mechanical properties, water resistance, and proteome of MA-silk and MI-silk from Araneus ventricosus and Trichonephila clavata. We also synthesized artificial fibers from major ampullate spidroin, MaSp1 and 2, and MiSp to compare their properties. Our proteomic analysis reveals that the MI-silk of both araneids is composed of MiSp, MaSp1, and spidroin constituting elements (SpiCEs). The absence of MaSp2 in the MI-silk proteome and the comparison of the water resistance of artificial fibers suggest that the presence of MaSp2 is the reason for the disparity in water resistance between MI-silk and MA-silk.

    DOI: 10.1021/acs.biomac.2c01474

    PubMed

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