Updated on 2023/09/21

写真a

 
OZAKI Norio
 
Organization
Graduate School of Medicine Designated professor
Title
Designated professor

Degree 1

  1. MD, PhD ( 1990.3   Nagoya University ) 

Research Interests 10

  1. 精神医学

  2. 神経科学

  3. 時間生物学

  4. 疫学

  5. ゲノム医学

  6. 精神医学

  7. 神経科学

  8. 疫学

  9. 時間生物学

  10. ゲノム医学

Research Areas 7

  1. Life Science / Hygiene and public health (laboratory)

  2. Life Science / Hygiene and public health (non-laboratory)

  3. Life Science / Psychiatry

  4. Life Science / Neuroscience-general

  5. Life Science / Medical management and medical sociology

  6. Humanities & Social Sciences / Gender studies

  7. Others / Others  / Medicine@Internal Medicine@Neuropsychiatry

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Current Research Project and SDGs 1

  1. 精神疾患の病態解明と病態に基づく診断治療法開発

Research History 10

  1. Nagoya University Graduate School of Medicine Pathophysiology of Mental Disorders   Designated professor

    2022.4

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    Country:Japan

  2. 東海国立大学機構   糖鎖生命コア研究所   特任教授

    2021.1

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    Country:Japan

  3. 名古屋大学大学院医学系研究科精神医学分野・親と子どもの心療学分野教授、 同病院精神科・親と子どもの心療科科長、2018年:同病院ゲノム医療センター長、遺伝カウンセリング部門長、2019年:同大学脳とこころの研究センター長

    2003.10 - 2022.3

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    Country:Japan

  4. 藤田保健衛生大学医学部精神医学教室教授

    1998.5 - 2003.9

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    Country:Japan

  5. 藤田保健衛生大学医学部精神医学教室講師

    1995.9 - 1998.4

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    Country:Japan

  6. 米国National Institute of Mental Health, Visiting Fellow

    1990.7 - 1995.8

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    Country:Japan

  7. 中部労災病院精神科医師

    1987.7 - 1990.6

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    Country:Japan

  8. 名古屋大学精神科医員

    1984.4 - 1987.6

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    Country:Japan

  9. 中京病院研修医

    1982.5 - 1984.3

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    Country:Japan

  10. Nagoya University   School of Medicine

    1982

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Education 1

  1. Nagoya University   Faculty of Medicine

    - 1982

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    Country: Japan

Professional Memberships 12

  1. World Federation of Biological Psychiatry   Executive Member(2005-2009)

  2. 日本精神神経学会   理事

  3. 日本うつ病学会   理事(前理事長)

  4. 日本統合失調症学会   理事

  5. 日本うつ病リワーク協会    理事

  6. 日本生物学的精神医学会   評議員(前理事長)

  7. 日本神経精神薬理学会   評議員

  8. 日本臨床精神神経薬理学会   評議員

  9. 日本人類遺伝学会   評議員

  10. 日本睡眠学会   評議員

  11. 日本脳科学関連学会連合   産学連携諮問委員会健康医療戦略検討グループ長(前副代表)

  12. 日本医学会   「遺伝子・健康・社会」検討委員会委員 など

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Papers 648

  1. Neuropathological substrate of incident dementia in older patients with schizophrenia: A clinicopathological study.

    Arafuka S, Fujishiro H, Torii Y, Sekiguchi H, Habuchi C, Miwa A, Yoshida M, Iritani S, Iwasaki Y, Ikeda M, Ozaki N

    Psychiatry and clinical neurosciences     2023.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pcn.13597

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  2. Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals

    Junya Matsumoto, Masaki Fukunaga, Kenichiro Miura, Kiyotaka Nemoto, Naohiro Okada, Naoki Hashimoto, Kentaro Morita, Daisuke Koshiyama, Kazutaka Ohi, Tsutomu Takahashi, Michihiko Koeda, Hidenaga Yamamori, Michiko Fujimoto, Yuka Yasuda, Satsuki Ito, Ryuichi Yamazaki, Naomi Hasegawa, Hisashi Narita, Satoshi Yokoyama, Ryo Mishima, Jun Miyata, Yuko Kobayashi, Daiki Sasabayashi, Kenichiro Harada, Maeri Yamamoto, Yoji Hirano, Takashi Itahashi, Masahito Nakataki, Ryu-ichiro Hashimoto, Khin K. Tha, Shinsuke Koike, Toshio Matsubara, Go Okada, Reiji Yoshimura, Osamu Abe, Theo G. M. van Erp, Jessica A. Turner, Neda Jahanshad, Paul M. Thompson, Toshiaki Onitsuka, Yoshiyuki Watanabe, Koji Matsuo, Hidenori Yamasue, Yasumasa Okamoto, Michio Suzuki, Norio Ozaki, Kiyoto Kasai, Ryota Hashimoto

    Molecular Psychiatry     2023.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), and autism spectrum disorder (ASD) are classified based on symptoms. While its cluster of symptoms defines each of these psychiatric disorders, there is also an overlap in symptoms between the disorders. We hypothesized that there are also similarities and differences in cortical structural neuroimaging features among these psychiatric disorders. T1-weighted magnetic resonance imaging scans were performed for 5,549 subjects recruited from 14 sites. Effect sizes were determined using a linear regression model within each protocol, and these effect sizes were meta-analyzed. The similarity of the differences in cortical thickness and surface area of each disorder group was calculated using cosine similarity, which was calculated from the effect sizes of each cortical regions. The thinnest cortex was found in SZ, followed by BD and MDD. The cosine similarity values between disorders were 0.943 for SZ and BD, 0.959 for SZ and MDD, and 0.943 for BD and MDD, which indicated that a common pattern of cortical thickness alterations was found among SZ, BD, and MDD. Additionally, a generally smaller cortical surface area was found in SZ and MDD than in BD, and the effect was larger in SZ. The cosine similarity values between disorders were 0.945 for SZ and MDD, 0.867 for SZ and ASD, and 0.811 for MDD and ASD, which indicated a common pattern of cortical surface area alterations among SZ, MDD, and ASD. Patterns of alterations in cortical thickness and surface area were revealed in the four major psychiatric disorders. To our knowledge, this is the first report of a cross-disorder analysis conducted on four major psychiatric disorders. Cross-disorder brain imaging research can help to advance our understanding of the pathogenesis of psychiatric disorders and common symptoms.

    DOI: 10.1038/s41380-023-02224-7

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    Other Link: https://www.nature.com/articles/s41380-023-02224-7

  3. Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification

    Okada Naohiro, Fukunaga Masaki, Miura Kenichiro, Nemoto Kiyotaka, Matsumoto Junya, Hashimoto Naoki, Kiyota Masahiro, Morita Kentaro, Koshiyama Daisuke, Ohi Kazutaka, Takahashi Tsutomu, Koeda Michihiko, Yamamori Hidenaga, Fujimoto Michiko, Yasuda Yuka, Hasegawa Naomi, Narita Hisashi, Yokoyama Satoshi, Mishima Ryo, Kawashima Takahiko, Kobayashi Yuko, Sasabayashi Daiki, Harada Kenichiro, Yamamoto Maeri, Hirano Yoji, Itahashi Takashi, Nakataki Masahito, Hashimoto Ryu-ichiro, Tha Khin K., Koike Shinsuke, Matsubara Toshio, Okada Go, van Erp Theo G. M., Jahanshad Neda, Yoshimura Reiji, Abe Osamu, Onitsuka Toshiaki, Watanabe Yoshiyuki, Matsuo Koji, Yamasue Hidenori, Okamoto Yasumasa, Suzuki Michio, Turner Jessica A., Thompson Paul M., Ozaki Norio, Kasai Kiyoto, Hashimoto Ryota

    MOLECULAR PSYCHIATRY     2023.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41380-023-02141-9

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  4. Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia. International journal

    Jingzhu Liao, Geyao Dong, Wenjun Zhu, Bolati Wulaer, Hiroyuki Mizoguchi, Masahito Sawahata, Yue Liu, Kozo Kaibuchi, Norio Ozaki, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada

    Pharmacological research   Vol. 194   page: 106838 - 106838   2023.8

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    Schizophrenia (SCZ) is a severe psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive deficits. Current antipsychotic treatment in SCZ improves positive symptoms but has major side effects and little impact on negative symptoms and cognitive impairment. The pathoetiology of SCZ remains unclear, but is known to involve small GTPase signaling. Rho kinase, an effector of small GTPase Rho, is highly expressed in the brain and plays a major role in neurite elongation and neuronal architecture. This study used a touchscreen-based visual discrimination (VD) task to investigate the effects of Rho kinase inhibitors on cognitive impairment in a methamphetamine (METH)-treated male mouse model of SCZ. Systemic injection of the Rho kinase inhibitor fasudil dose-dependently ameliorated METH-induced VD impairment. Fasudil also significantly suppressed the increase in the number of c-Fos-positive cells in the infralimbic medial prefrontal cortex (infralimbic mPFC) and dorsomedial striatum (DMS) following METH treatment. Bilateral microinjections of Y-27632, another Rho kinase inhibitor, into the infralimbic mPFC or DMS significantly ameliorated METH-induced VD impairment. Two proteins downstream of Rho kinase, myosin phosphatase-targeting subunit 1 (MYPT1; Thr696) and myosin light chain kinase 2 (MLC2; Thr18/Ser19), exhibited increased phosphorylation in the infralimbic mPFC and DMS, respectively, after METH treatment, and fasudil inhibited these increases. Oral administration of haloperidol and fasudil ameliorated METH-induced VD impairment, while clozapine had little effect. Oral administration of haloperidol and clozapine suppressed METH-induced hyperactivity, but fasudil had no effect. These results suggest that METH activates Rho kinase in the infralimbic mPFC and DMS, which leads to cognitive impairment in male mice. Rho kinase inhibitors ameliorate METH-induced cognitive impairment, perhaps via the cortico-striatal circuit.

    DOI: 10.1016/j.phrs.2023.106838

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  5. Evaluating sleep-wake rhythm using a wearable device in patients with mental disorders. International journal

    Seiko Miyata, Kunihiro Iwamoto, Norio Ozaki

    Psychiatry and clinical neurosciences   Vol. 77 ( 8 ) page: 419 - 419   2023.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pcn.13568

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  6. Feasibility of a wrist-worn wearable device for estimating mental health status in patients with mental illness

    Nakagome Kazuyuki, Makinodan Manabu, Uratani Mitsuhiro, Kato Masaki, Ozaki Norio, Miyata Seiko, Iwamoto Kunihiro, Hashimoto Naoki, Toyomaki Atsuhito, Mishima Kazuo, Ogasawara Masaya, Takeshima Masahiro, Minato Kazumichi, Fukami Toshikazu, Oba Mari, Takeda Kazuyoshi, Oi Hideki

    FRONTIERS IN PSYCHIATRY   Vol. 14   page: 1189765   2023.7

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    DOI: 10.3389/fpsyt.2023.1189765

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  7. Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder

    Amare Azmeraw T., Thalamuthu Anbupalam, Schubert Klaus Oliver, Fullerton Janice M., Ahmed Muktar, Hartmann Simon, Papiol Sergi, Heilbronner Urs, Degenhardt Franziska, Tekola-Ayele Fasil, Hou Liping, Hsu Yi-Hsiang, Shekhtman Tatyana, Adli Mazda, Akula Nirmala, Akiyama Kazufumi, Ardau Raffaella, Arias Barbara, Aubry Jean-Michel, Hasler Roland, Richard-Lepouriel Helene, Perroud Nader, Backlund Lena, Bhattacharjee Abesh Kumar, Bellivier Frank, Benabarre Antonio, Bengesser Susanne, Biernacka Joanna M., Birner Armin, Marie-Claire Cynthia, Cervantes Pablo, Chen Hsi-Chung, Chillotti Caterina, Cichon Sven, Cruceanu Cristiana, Czerski Piotr M., Dalkner Nina, Del Zompo Maria, DePaulo J. Raymond, etain Bruno, Jamain Stephane, Falkai Peter, Forstner Andreas J., Frisen Louise, Frye Mark A., Gard Sebastien, Garnham Julie S., Goes Fernando S., Grigoroiu-Serbanescu Maria, Fallgatter Andreas J., Stegmaier Sophia, Ethofer Thomas, Biere Silvia, Petrova Kristiyana, Schuster Ceylan, Adorjan Kristina, Budde Monika, Heilbronner Maria, Kalman Janos L., Kohshour Mojtaba Oraki, Reich-Erkelenz Daniela, Schaupp Sabrina K., Schulte Eva C., Senner Fanny, Vogl Thomas, Anghelescu Ion-George, Arolt Volker, Dannlowski Udo, Dietrich Detlef, Figge Christian, Jaeger Markus, Lang Fabian U., Juckel Georg, Konrad Carsten, Reimer Jens, Schmauss Max, Schmitt Andrea, Spitzer Carsten, von Hagen Martin, Wiltfang Jens, Zimmermann Joerg, Andlauer Till F. M., Fischer Andre, Bermpohl Felix, Ritter Philipp, Matura Silke, Gryaznova Anna, Falkenberg Irina, Yildiz Cueneyt, Kircher Tilo, Schmidt Julia, Koch Marius, Gade Kathrin, Trost Sarah, Haussleiter Ida S., Lambert Martin, Rohenkohl Anja C., Kraft Vivien, Grof Paul, Hashimoto Ryota, Hauser Joanna, Herms Stefan, Hoffmann Per, Jimenez Esther, Kahn Jean-Pierre, Kassem Layla, Kuo Po-Hsiu, Kato Tadafumi, Kelsoe John, Kittel-Schneider Sarah, Ferensztajn-Rochowiak Ewa, Koenig Barbara, Kusumi Ichiro, Laje Gonzalo, Landen Mikael, Lavebratt Catharina, Leboyer Marion, Leckband Susan G., Tortorella Alfonso, Manchia Mirko, Martinsson Lina, McCarthy Michael J., McElroy Susan, Colom Francesc, Millischer Vincent, Mitjans Marina, Mondimore Francis M., Monteleone Palmiero, Nievergelt Caroline M., Noethen Markus M., Novak Tomas, O'Donovan Claire, Ozaki Norio, Pfennig Andrea, Pisanu Claudia, Potash James B., Reif Andreas, Reininghaus Eva, Rouleau Guy A., Rybakowski Janusz K., Schalling Martin, Schofield Peter R., Schweizer Barbara W., Severino Giovanni, Shilling Paul D., Shimoda Katzutaka, Simhandl Christian, Slaney Claire M., Squassina Alessio, Stamm Thomas, Stopkova Pavla, Maj Mario, Turecki Gustavo, Vieta Eduard, Veeh Julia, Witt Stephanie H., Wright Adam, Zandi Peter P., Mitchell Philip B., Bauer Michael, Alda Martin, Rietschel Marcella, McMahon Francis J., Schulze Thomas G., Clark Scott R., Baune Bernhard T.

    MOLECULAR PSYCHIATRY     2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41380-023-02149-1

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  8. Neuropsychopharmacology renaissance in Japan: A new era after the crisis

    Ozaki Norio, Kimura Teiji, Kikuchi Tetsuro, Ishiyama Takeo

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 77 ( 7 ) page: 375 - 376   2023.7

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    DOI: 10.1111/pcn.13549

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  9. 4大精神疾患の大脳構造の類似度の解析 大脳皮質厚と大脳皮質表面積の多施設共同疾患横断解析

    松本 純弥, 福永 雅喜, 三浦 健一郎, 根本 清貴, 岡田 直大, 橋本 直樹, 森田 健太郎, 越山 太輔, 大井 一高, 高橋 努, 肥田 道彦, 山森 英長, 藤本 美智子, 安田 由華, 伊藤 颯姫, 山崎 龍一, 長谷川 尚美, 成田 尚, 横山 仁史, 三嶋 亮, 宮田 淳, 小林 祐子, 笹林 大樹, 原田 健一郎, 山本 真江里, 平野 羊嗣, 板橋 貴史, 中瀧 理仁, 橋本 龍一郎, タ・キンキン, 小池 進介, 松原 敏郎, 岡田 剛, 吉村 玲児, 阿部 修, 鬼塚 俊明, 渡邊 嘉之, 松尾 幸治, 山末 英典, 岡本 泰昌, 鈴木 道雄, 尾崎 紀夫, 笠井 清登, 橋本 亮太

    国立精神・神経医療研究センター精神保健研究所年報   ( 36 ) page: 210 - 210   2023.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:(国研)国立精神・神経医療研究センター精神保健研究所  

  10. Interaction of genetic liability for attention deficit hyperactivity disorder (ADHD) and perinatal inflammation contributes to ADHD symptoms in children Reviewed

    Nagahide Takahashi, Tomoko Nishimura, Taeko Harada, Akemi Okumura, Toshiki Iwabuchi, Md Shafiur Rahman, Hitoshi Kuwabara, Shu Takagai, Noriyoshi Usui, Manabu Makinodan, Hideo Matsuzaki, Norio Ozaki, Hiroaki Itoh, Yoko Nomura, Jeffrey H. Newcorn, Kenji J. Tsuchiya

    Brain, Behavior, & Immunity - Health   Vol. 30   page: 100630 - 100630   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.bbih.2023.100630

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  11. Structural aging of human neurons is opposite of the changes in schizophrenia. International journal

    Ryuta Mizutani, Rino Saiga, Yoshiro Yamamoto, Masayuki Uesugi, Akihisa Takeuchi, Kentaro Uesugi, Yasuko Terada, Yoshio Suzuki, Vincent De Andrade, Francesco De Carlo, Susumu Takekoshi, Chie Inomoto, Naoya Nakamura, Youta Torii, Itaru Kushima, Shuji Iritani, Norio Ozaki, Kenichi Oshima, Masanari Itokawa, Makoto Arai

    PloS one   Vol. 18 ( 6 ) page: e0287646   2023.6

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    Human mentality develops with age and is altered in psychiatric disorders, though their underlying mechanism is unknown. In this study, we analyzed nanometer-scale three-dimensional structures of brain tissues of the anterior cingulate cortex from eight schizophrenia and eight control cases. The distribution profiles of neurite curvature of the control cases showed a trend depending on their age, resulting in an age-correlated decrease in the standard deviation of neurite curvature (Pearson's r = -0.80, p = 0.018). In contrast to the control cases, the schizophrenia cases deviate upward from this correlation, exhibiting a 60% higher neurite curvature compared with the controls (p = 7.8 × 10-4). The neurite curvature also showed a correlation with a hallucination score (Pearson's r = 0.80, p = 1.8 × 10-4), indicating that neurite structure is relevant to brain function. This report is based on our 3D analysis of human brain tissues over a decade and is unprecedented in terms of the number of cases. We suggest that neurite curvature plays a pivotal role in brain aging and can be used as a hallmark to exploit a novel treatment of schizophrenia.

    DOI: 10.1371/journal.pone.0287646

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  12. Case reports of two siblings with autism spectrum disorder and 15q13.3 deletions

    Furukawa Sawako, Kushima Itaru, Aleksic Branko, Ozaki Norio

    NEUROPSYCHOPHARMACOLOGY REPORTS   Vol. 43 ( 3 ) page: 462 - 466   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/npr2.12340

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  13. 【精神疾患レジストリによって何がわかるか?】血液由来試料の解析と縦断データに基づく,精神疾患の治療効果および予後に関する層別化

    中村 真理子, 吉見 陽, 野田 幸裕, 尾崎 紀夫

    精神科   Vol. 42 ( 6 ) page: 726 - 737   2023.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:(有)科学評論社  

  14. Clinical characterization of patients with schizophrenia and 16p13.11 duplication: A case series. International journal

    Hiroki Kimura, Itaru Kushima, Masahiro Banno, Toshiya Inada, Akira Yoshimi, Branko Aleksic, Norio Ozaki

    Neuropsychopharmacology reports   Vol. 43 ( 2 ) page: 267 - 271   2023.6

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    BACKGROUND: Chromosome 16p13.11 duplication is a well-known genetic risk factor for schizophrenia (SCZ) (odds ratio = 1.84). However, no case reports focusing on patients with SCZ and 16p13.11 duplication have been published. Therefore, here, we report the detailed clinical cases of four patients with SCZ and 16p13.11 duplication who were identified in our previous whole-genome copy number variant (CNV) study. CASE PRESENTATION: In the four patients with SCZ and 16p13.11 duplication detected by array comparative genomic hybridization, one patient was found to have treatment-resistant SCZ and an additional pathogenic rare CNV. Two of the four patients in this study had environmental risk factors that may have been involved in the development of SCZ. CONCLUSIONS: The results of this case series suggest that a genetic cohort study would be useful for evaluating which genetic and environmental risk factors could better explain the variable expressivity of 16p13.11 duplication. Furthermore, this work could be useful for elucidating the pathophysiology of SCZ.

    DOI: 10.1002/npr2.12334

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  15. The new guideline for evaluating effects of psychotropic drugs on the performance to drive a motor vehicle in Japan: Comparison with US FDA guideline. International journal

    Kunihiro Iwamoto, Tetsuo Nakabayashi, Akiko Yamaguchi, Yuki Konishi, Momoe Saji, Reiji Yoshimura, Kousuke Kanemoto, Hirofumi Aoki, Masahiko Ando, Norio Ozaki

    Neuropsychopharmacology reports   Vol. 43 ( 2 ) page: 172 - 176   2023.6

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    In December 2022, the new guideline for evaluating the effect of psychotropic drugs on the performance to drive a motor vehicle was issued by the Ministry of Health, Labour and Welfare (MHLW) and implemented in Japan. Of the safety information, information on the influence of medications on driving performance is particularly important because it can be relevant to the social functioning of patients. In principle, the package inserts of medications are designed based on evidence and provide precautions regarding the operation of heavy machinery such as automobiles in Japan, the United States, and Europe. The effects of medications on driving performance are generally evaluated in a tiered approach involving nonclinical and clinical studies. Because of the wide variety of functional domains involved in automobile driving, the selection of evaluation methods for a given medication depends on their characteristics, which is a complicated method. Therefore, to evaluate the effects of psychotropic drugs on driving performance efficiently and appropriately, we developed the MHLW guideline that specifically defines the evaluation methods used in pharmacological studies, the neuropsychological tests used in pharmacodynamic studies, and the situations in which driving studies are necessary. Regarding the planning of appropriate drug development strategies, we review the background of the MHLW guideline and its differences from the US Food and Drug Administration (FDA) guideline.

    DOI: 10.1002/npr2.12339

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  16. LONG-TERM EFFICACY OF LEMBOREXANT ON OBJECTIVE SLEEP MEASURES IN CLINICAL PRACTICE

    Miyata Seiko, Iwamoto Kunihiro, Okada Ippei, Fujimoto Akihiro, Kogo Yuki, Amano Manabu, Matsuyama Nao, Ozaki Norio

    SLEEP   Vol. 46   2023.5

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  17. [How to Use Psychotropic Drugs During the Perinatal Period: Risks and Benefits for Fetuses and Infants].

    Wada S, Ogasawara K, Ozaki N

    Brain and nerve = Shinkei kenkyu no shinpo   Vol. 75 ( 5 ) page: 645 - 651   2023.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.11477/mf.1416202392

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  18. Histological Analysis of a Mouse Model of the 22q11.2 Microdeletion Syndrome

    Tabata Hidenori, Mori Daisuke, Matsuki Tohru, Yoshizaki Kaichi, Asai Masato, Nakayama Atsuo, Ozaki Norio, Nagata Koh-ichi

    BIOMOLECULES   Vol. 13 ( 5 )   2023.4

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    DOI: 10.3390/biom13050763

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  19. Comorbid psychiatric disorders and long-term survival after liver transplantation in transplant facilities with a psychiatric consultation-liaison team: a multicenter retrospective study

    Kimura Hiroyuki, Kishi Shinichi, Narita Hisashi, Tanaka Teruaki, Okada Tsuyoshi, Fujisawa Daisuke, Sugita Naoko, Noma Shun'ichi, Matsumoto Yosuke, Ohashi Ayako, Mitsuyasu Hiroshi, Yoshida Keizo, Kawasaki Hiroaki, Nishimura Katsuji, Ogura Yasuhiro, Ozaki Norio

    BMC GASTROENTEROLOGY   Vol. 23 ( 1 ) page: 106   2023.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12876-023-02735-1

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  20. Molecular diagnosis of 405 individuals with autism spectrum disorder. International journal

    Noriko Miyake, Yoshinori Tsurusaki, Ryoko Fukai, Itaru Kushima, Nobuhiko Okamoto, Kei Ohashi, Kazuhiko Nakamura, Ryota Hashimoto, Yoko Hiraki, Shuraku Son, Mitsuhiro Kato, Yasunari Sakai, Hitoshi Osaka, Kimiko Deguchi, Toyojiro Matsuishi, Saoko Takeshita, Aviva Fattal-Valevski, Nina Ekhilevitch, Jun Tohyama, Patrick Yap, Wee Teik Keng, Hiroshi Kobayashi, Keiyo Takubo, Takashi Okada, Shinji Saitoh, Yuka Yasuda, Toshiya Murai, Kazuyuki Nakamura, Shouichi Ohga, Ayumi Matsumoto, Ken Inoue, Tomoko Saikusa, Tova Hershkovitz, Yu Kobayashi, Mako Morikawa, Aiko Ito, Toshiro Hara, Yota Uno, Chizuru Seiwa, Kanako Ishizuka, Emi Shirahata, Atsushi Fujita, Eriko Koshimizu, Satoko Miyatake, Atsushi Takata, Takeshi Mizuguchi, Norio Ozaki, Naomichi Matsumoto

    European journal of human genetics : EJHG     2023.3

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    Autism spectrum disorder (ASD) is caused by combined genetic and environmental factors. Genetic heritability in ASD is estimated as 60-90%, and genetic investigations have revealed many monogenic factors. We analyzed 405 patients with ASD using family-based exome sequencing to detect disease-causing single-nucleotide variants (SNVs), small insertions and deletions (indels), and copy number variations (CNVs) for molecular diagnoses. All candidate variants were validated by Sanger sequencing or quantitative polymerase chain reaction and were evaluated using the American College of Medical Genetics and Genomics/Association for Molecular Pathology guidelines for molecular diagnosis. We identified 55 disease-causing SNVs/indels in 53 affected individuals and 13 disease-causing CNVs in 13 affected individuals, achieving a molecular diagnosis in 66 of 405 affected individuals (16.3%). Among the 55 disease-causing SNVs/indels, 51 occurred de novo, 2 were compound heterozygous (in one patient), and 2 were X-linked hemizygous variants inherited from unaffected mothers. The molecular diagnosis rate in females was significantly higher than that in males. We analyzed affected sibling cases of 24 quads and 2 quintets, but only one pair of siblings shared an identical pathogenic variant. Notably, there was a higher molecular diagnostic rate in simplex cases than in multiplex families. Our simulation indicated that the diagnostic yield is increasing by 0.63% (range 0-2.5%) per year. Based on our simple simulation, diagnostic yield is improving over time. Thus, periodical reevaluation of ES data should be strongly encouraged in undiagnosed ASD patients.

    DOI: 10.1038/s41431-023-01335-7

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  21. Shedding light on latent pathogenesis and pathophysiology of mental disorders: the potential of iPS cell technology.

    Arioka Y, Okumura H, Sakaguchi H, Ozaki N

    Psychiatry and clinical neurosciences     2023.3

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    DOI: 10.1111/pcn.13545

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  22. Astrotactin 2 (ASTN2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems

    Ito Takahiro, Yoshida Mikio, Aida Tomomi, Kushima Itaru, Hiramatsu Yuka, Ono Maiko, Yoshimi Akira, Tanaka Kohichi, Ozaki Norio, Noda Yukihiro

    JOURNAL OF NEUROCHEMISTRY     2023.3

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    DOI: 10.1111/jnc.15790

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  23. Sensory evaluation of the bitterness of asenapine using D-sorbitol pretreatment: single-blind, placebo-controlled, crossover trial. International journal

    Shuhei Wada, Kunihiro Iwamoto, Hiroki Okumura, Hirotake Hida, Shuichi Hiraoka, Aya Kamei, Daisuke Mori, Kiyofumi Yamada, Norio Ozaki

    BMC psychiatry   Vol. 23 ( 1 ) page: 159 - 159   2023.3

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    BACKGROUND: Antipsychotics are essential in the acute treatment of and maintenance therapy for schizophrenia, but medication adherence and long-term treatment continuity are needed to maximize their effectiveness. Each antipsychotic has various side effects, which may affect adherence. Some patients with schizophrenia are reluctant to take asenapine because of its unique oral-related side effects, such as the bitter taste caused by sublingual administration. Our previous basic research found that D-sorbitol lowered the bitterness parameters of the taste sensors. However, whether D-sorbitol has the same effect in patients remains unclear. Therefore, using a D-sorbitol solution, we aim to evaluate changes in the bitterness of asenapine among patients with schizophrenia. METHODS: In this single-blind, placebo-controlled, crossover trial, we plan to recruit 20 adult patients with schizophrenia spectrum disorder who take sublingual asenapine tablets. The participants will be divided into two groups (n = 10 each). Each group will be given a D-sorbitol or placebo solution on the first day for rinsing before taking the sublingual asenapine tablets. After a 1-day interval, the participants will rinse their mouths again with a different liquid. Questionnaires regarding changes in taste and the willingness to continue asenapine will be conducted before the start of the study and after each rinse. The primary and secondary end points will be a taste evaluation of bitterness, and the willingness to continue asenapine, respectively. Differences in questionnaire scores between the D-sorbitol and placebo solutions will be calculated and analyzed using a McNemar test. DISCUSSION: This study aims to determine the efficacy of D-sorbitol in masking the bitter taste of asenapine. To our knowledge, it is the first intervention study using D-sorbitol for bitter taste of asenapine in patients with schizophrenia. Evidence of the efficacy of D-sorbitol could result in D-sorbitol pretreatment being an easy and inexpensive means of improving adherence to asenapine. TRIAL REGISTRATION: This study was registered in the Japan Registry of Clinical Trials jRCTs041210019, on May 14, 2021. Ethics approval was obtained from the Nagoya University Clinical Research Review Board.

    DOI: 10.1186/s12888-023-04664-5

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  24. An autopsy case of schizophrenia comorbid with argyrophilic grain disease. International journal

    Youta Torii, Shuji Iritani, Hiroshige Fujishiro, Hirotaka Sekiguchi, Chikako Habuchi, Toshimasa Ikeda, Mari Yoshida, Yasushi Iwasaki, Norio Ozaki, Kunihiro Kawashima

    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society   Vol. 23 ( 2 ) page: 371 - 373   2023.3

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    DOI: 10.1111/psyg.12935

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  25. Late-onset panic disorder as the initial presentation in autopsy-confirmed dementia with Lewy bodies. International journal

    Shusei Arafuka, Hirotaka Sekiguchi, Hiroshige Fujishiro, Shuji Iritani, Youta Torii, Chikako Habuchi, Mari Yoshida, Yasushi Iwasaki, Norio Ozaki, Kiyoshi Fujita

    Psychiatry and clinical neurosciences   Vol. 77 ( 4 ) page: 242 - 244   2023.2

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    DOI: 10.1111/pcn.13532

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  26. A case of bipolar disorder with AIF1 (coding gene of Iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells

    Ohgidani Masahiro, Kushima Itaru, Inamine Shogo, Kyuragi Sota, Sagata Noriaki, Nakao Tomohiro, Kanba Shigenobu, Ozaki Norio, Kato Takahiro A.

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 77 ( 2 ) page: 128 - 130   2023.2

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    DOI: 10.1111/pcn.13505

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  27. Clinical manifestations of schizophrenia in four patients with variants in voltage-gated calcium channel-encoding genes: a case series. International journal

    Tzuyao Lo, Itaru Kushima, Branko Aleksic, Akira Yoshimi, Toshiyuki Someya, Yuichiro Watanabe, Norio Ozaki

    Psychiatry and clinical neurosciences   Vol. 77 ( 1 ) page: 57 - 59   2023.1

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    DOI: 10.1111/pcn.13494

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  28. Temporal trajectories of proposed biomarkers in psychiatric-onset prodromal dementia with Lewy bodies: a case report. International journal

    Hiroshige Fujishiro, Shusei Arafuka, Kazuyoshi Ogasawara, Kunihiro Iwamoto, Seiko Miyata, Youta Torii, Shuji Iritani, Norio Ozaki

    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society   Vol. 23 ( 1 ) page: 196 - 200   2023.1

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    DOI: 10.1111/psyg.12922

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  29. Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene Reviewed

    Rinako Tanaka, Jingzhu Liao, Kazuhiro Hada, Daisuke Mori, Taku Nagai, Tetsuo Matsuzaki, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroyuki Mizoguchi, Kiyofumi Yamada

    Pharmacological Research   Vol. 187   page: 106589 - 106589   2023.1

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    DOI: 10.1016/j.phrs.2022.106589

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  30. Exploratory Validation of Sleep-Tracking Devices in Patients with Psychiatric Disorders

    Ogasawara Masaya, Takeshima Masahiro, Kosaka Shumpei, Imanishi Aya, Itoh Yu, Fujiwara Dai, Yoshizawa Kazuhisa, Ozaki Norio, Nakagome Kazuyuki, Mishima Kazuo

    NATURE AND SCIENCE OF SLEEP   Vol. 15   page: 301 - 312   2023

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    DOI: 10.2147/NSS.S400944

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  31. Comparison of quality of life and psychological distress in patients with tongue cancer undergoing a total/subtotal glossectomy or extended hemiglossectomy and free flap transfer: a prospective evaluation

    K. Suzuki, N. Nishio, H. Kimura, T. Tokura, S. Kishi, N. Ozaki, Y. Fujimoto, M. Sone

    International Journal of Oral and Maxillofacial Surgery     2022.12

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    DOI: 10.1016/j.ijom.2022.11.010

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  32. Turner syndrome presenting with idiopathic regression: A case report

    Mizobuchi Kosuke, Kushima Itaru, Kato Hidekazu, Miyajima Mari, Kimura Hiroyuki, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 76 ( 12 ) page: 680 - 682   2022.12

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    DOI: 10.1111/pcn.13483

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  33. Reproducibility of functional connectivity metrics estimated from resting-state functional MRI with differences in days, coils, and global signal regression

    Kato Sanae, Bagarinao Epifanio, Isoda Haruo, Koyama Shuji, Watanabe Hirohisa, Maesawa Satoshi, Hara Kazuhiro, Katsuno Masahisa, Naganawa Shinji, Ozaki Norio, Sobue Gen

    RADIOLOGICAL PHYSICS AND TECHNOLOGY   Vol. 15 ( 4 ) page: 298 - 310   2022.12

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    DOI: 10.1007/s12194-022-00670-6

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  34. Prevalence of obstructive sleep apnea as assessed by polysomnography in psychiatric patients with sleep-related problems. International journal

    Ippei Okada, Seiko Miyata, Kunihiro Iwamoto, Hiroshige Fujishiro, Akiko Noda, Norio Ozaki

    Sleep & breathing = Schlaf & Atmung   Vol. 26 ( 4 ) page: 1983 - 1991   2022.12

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    PURPOSE: Patients with psychiatric disorders often complain of sleep disturbances and are frequently suspected of obstructive sleep apnea (OSA). However, data regarding sleep problems evaluated by attended polysomnography (PSG) remain limited in this population. We analyzed the results of attended PSG from psychiatric patients with sleep-related problems to determine the prevalence and features of sleep disorders among this population. METHODS: We retrospectively investigated the attended PSG results of patients with psychiatric disorders: major depressive disorder, bipolar disorder, neurodevelopmental disorder, schizophrenia, neurocognitive disorder, anxiety disorder, somatic symptom disorder. RESULTS: Of 264 patients, 158 men (60%), mean age was 47 ± 19.9 years. More than half of the patients with major depressive disorder (62%), bipolar disorder (70%), schizophrenia (58%), neurocognitive disorders (55%), and somatic symptom disorder (56%) had OSA. Among the psychiatric patients with OSA, 62% of these patients had moderate to severe OSA. The risk factors for OSA were snoring, male, age, and body mass index. The presence of OSA was not associated with the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale score, or benzodiazepine, antipsychotic, or antidepressant use. Other sleep disorders were insomnia (19%), central disorders of hypersomnia (8%), restless legs syndrome/periodic limb movement of sleep (8%), rapid eye movement sleep behavior disorder (7%), and central sleep apnea syndrome (3%). CONCLUSIONS: PSG revealed that moderate to severe OSA was common in psychiatric patients with or without snoring. Subjective symptoms and psychotropics did not predict OSA. Therefore, PSG is needed to reveal sleep conditions in patients with psychiatric disorders.

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  35. X chromosome aneuploidies and schizophrenia: association analysis and phenotypic characterization

    Itaru Kushima, Branko Aleksic, Hiroki Kimura, Masahiro Nakatochi, Tzuyao Lo, Masashi Ikeda, Makoto Arai, Ryota Hashimoto, Shusuke Numata, Yasunobu Okamura, Taku Obara, Toshiya Inada, Norio Ozaki

    Psychiatry and Clinical Neurosciences   Vol. 76 ( 12 ) page: 667 - 673   2022.12

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    DOI: 10.1111/pcn.13474

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  36. Memantine ameliorates the impairment of social behaviors induced by a single social defeat stress as juveniles

    Mikio Yoshida, Sho Hasegawa, Masayuki Taniguchi, Akihiro Mouri, Chiharu Suzuki, Akira Yoshimi, Takayoshi Mamiya, Norio Ozaki, Yukihiro Noda

    Neuropharmacology   Vol. 217   page: 109208 - 109208   2022.10

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    DOI: 10.1016/j.neuropharm.2022.109208

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  37. Establishment of induced pluripotent stem cells from a patient with 16p13.11 duplication and VPS13B deletion

    Okumura Hiroki, Arioka Yuko, Kushima Itaru, Mori Daisuke, Ozaki Norio

    STEM CELL RESEARCH   Vol. 64   page: 102884   2022.10

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    DOI: 10.1016/j.scr.2022.102884

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  38. エネルギー器官としての脳 組織構造と統合失調症

    糸川 昌成, 大島 健一, 鳥海 和也, 吉川 茜, 堀内 泰江, 宮下 光弘, 宮野 康寛, 石田 裕昭, 小堀 晶子, 井上 智子, 新井 誠, 鳥居 洋太, 久島 周, 入谷 修司, 尾崎 紀夫, 鈴木 芳生, 野口 千太, 雑賀 里乃, 水谷 隆太

    精神神経学雑誌   Vol. 124 ( 10 ) page: 688 - 699   2022.10

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    統合失調症研究にとって脳は中心的な標的器官である.脳は重量比にして体重の50分の1程度の小さな臓器だが,膨大なエネルギー(全グルコースの5分の1,酸素の4分の1)を必要とする.膨大な酸素とグルコースは,ミトコンドリアの酸化的リン酸化という代謝過程を経てATPにエネルギー転換され,これは神経細胞の静止膜電位の維持に消費される.脳は高度に機能分化した局所の集合体でもあり,血管系と神経系が緻密に連携することで,エネルギーを細部へ効果的に届けることができている.この脳の特徴-グルコース酸化と神経血管カップリング-から,統合失調症の代謝と構造について概説し,統合失調症研究の再現性問題を解決する方策の1例として,症候群から抽出した糖化ストレスを伴う小亜種を紹介した.脳構造を個人差レベルまで識別できる解像度をもつ放射光ナノCT法により,脳血管と神経細胞の構造アンバランスを同定した自験例を,統合失調症のエネルギー代謝研究への応用例として紹介した.(著者抄録)

    Other Link: https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00755&link_issn=&doc_id=20221031250002&doc_link_id=vol%3D124%26year%3D2022%26mag%3D0%26number%3D10%26start%3D688&url=https%3A%2F%2Fjournal.jspn.or.jp%2FDisp%3Fstyle%3Dabst%26vol%3D124%26year%3D2022%26mag%3D0%26number%3D10%26start%3D688&type=%E7%B2%BE%E7%A5%9E%E7%A5%9E%E7%B5%8C%E5%AD%A6%E9%9B%91%E8%AA%8C&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00022_2.gif

  39. Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia. International journal

    Saeko Takase, Jingzhu Liao, Yue Liu, Rinako Tanaka, Yasuhiro Miyagawa, Masahito Sawahata, Akira Sobue, Hiroyuki Mizoguchi, Taku Nagai, Kozo Kaibuchi, Norio Ozaki, Kiyofumi Yamada

    European journal of pharmacology   Vol. 931   page: 175207 - 175207   2022.9

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    Current antipsychotics used to treat schizophrenia have associated problems, including serious side effects and treatment resistance. We recently identified a significant association of schizophrenia with exonic copy number variations in the Rho GTPase activating protein 10 (ARHGAP10) gene using genome-wide analysis. ARHGAP10 encodes a RhoGAP superfamily member that is involved in small GTPase signaling. In mice, Arhgap10 gene variations result in RhoA/Rho-kinase pathway activation. We evaluated the pharmacokinetics of fasudil and hydroxyfasudil using liquid chromatography-tandem mass spectrometry in mice. The antipsychotic effects of fasudil on hyperlocomotion, social interaction deficits, prepulse inhibition deficits, and novel object recognition deficits were also investigated in a MK-801-treated pharmacological mouse schizophrenia model. Fasudil and its major metabolite, hydroxyfasudil, were detected in the brain at concentrations above their respective Ki values for Rho-kinase after intraperitoneal injection of 10 mg kg-1 fasudil. Fasudil improved the hyperlocomotion, social interaction deficits, prepulse inhibition deficits, and novel object recognition deficits in MK-801-treated mice in a dose-dependent manner. Following oral administration of fasudil, brain hydroxyfasudil was detected at concentration above the Ki value for Rho-kinase whilst fasudil was undetectable. MK-801-induced hyperlocomotion was also improved by oral fasudil administration. These results suggest that fasudil has antipsychotic-like effects on the MK-801-treated pharmacological mouse schizophrenia model. There are two isoforms in Rho-kinase, and further investigation is needed to clarify the isoforms involved in the antipsychotic-like effects of fasudil in the MK-801-treated mouse schizophrenia model.

    DOI: 10.1016/j.ejphar.2022.175207

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  40. Case series of four psychiatric patients with copy number variations in the neurexin 1 gene

    Itaru Kushima, Toshiya Inada, Kazutaka Ohi, Jun Egawa, Norio Ozaki

    Psychiatry and Clinical Neurosciences Reports   Vol. 1 ( 3 )   2022.9

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    DOI: 10.1002/pcn5.36

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  41. Cross-disorder analysis of genic and regulatory copy number variations in bipolar disorder, schizophrenia, and autism spectrum disorder

    Itaru Kushima, Masahiro Nakatochi, Branko Aleksic, Takashi Okada, Hiroki Kimura, Hidekazu Kato, Mako Morikawa, Toshiya Inada, Kanako Ishizuka, Youta Torii, Yukako Nakamura, Satoshi Tanaka, Miho Imaeda, Nagahide Takahashi, Maeri Yamamoto, Kunihiro Iwamoto, Yoshihiro Nawa, Nanayo Ogawa, Shuji Iritani, Yu Hayashi, Tzuyao Lo, Gantsooj Otgonbayar, Sho Furuta, Nakao Iwata, Masashi Ikeda, Takeo Saito, Kohei Ninomiya, Tomo Okochi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kenichiro Miura, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Kazutaka Ohi, Toshiki Shioiri, Kiyoyuki Kitaichi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Tsukasa Sasaki, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Hitoshi Kuwabara, Tomoyasu Wakuda, Takahiro A. Kato, Shigenobu Kanba, Hideki Horikawa, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Takeo Yoshikawa, Tomoko Toyota, Shigeru Yokoyama, Toshio Munesue, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Minyoung Jung, Kiyoto Kasai, Tempei Ikegame, Seiichiro Jinde, Shusuke Numata, Makoto Kinoshita, Tadafumi Kato, Chihiro Kakiuchi, Kazuhiro Yamakawa, Toshimitsu Suzuki, Naoki Hashimoto, Shuhei Ishikawa, Bun Yamagata, Shintaro Nio, Toshiya Murai, Shuraku Son, Yasuto Kunii, Hirooki Yabe, Masumi Inagaki, Yu-ichi Goto, Yuto Okumura, Tomoya Ito, Yuko Arioka, Daisuke Mori, Norio Ozaki

    Biological Psychiatry   Vol. 92 ( 5 ) page: 362 - 374   2022.9

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    DOI: 10.1016/j.biopsych.2022.04.003

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  42. A Reactive Metabolite of Clozapine Induces Hematopoietic Toxicity in HL-60 Cells Undergoing Granulocytic Differentiation through Its Effect on Glutathione Metabolism

    Torii-Goto Aya, Yoshimi Akira, Tashiro Yuko, Ukigai Mako, Matsumoto Aoi, Ozaki Norio, Noda Yukihiro

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   Vol. 45 ( 9 ) page: 1232 - 1237   2022.9

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  43. Psychological impact on patients with oral cancer before undergoing resection and free flap reconstruction surgery

    Satoshi Yamaguchi, Kento Kaminogo, Tatsuya Tokura, Hiroyuki Kimura, Shinichi Kishi, Noriyuki Yamamoto, Norihisa Ichimura, Naoto Toyama, Yoshiro Koma, Naoka Kouyama, Norio Ozaki, Hideharu Hibi

    Oral Oncology Reports   Vol. 3-4   page: 100004 - 100004   2022.9

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    DOI: 10.1016/j.oor.2022.100004

  44. Contribution of copy number variations to the risk of severe eating disorders

    Itaru Kushima, Miho Imaeda, Satoshi Tanaka, Hidekazu Kato, Tomoko Oya‐Ito, Masahiro Nakatochi, Branko Aleksic, Norio Ozaki

    Psychiatry and Clinical Neurosciences   Vol. 76 ( 9 ) page: 423 - 428   2022.9

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    DOI: 10.1111/pcn.13430

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pcn.13430

  45. 精神科外来患者における抗うつ薬および抗不安薬の多剤併用処方状況に関する調査

    肥田 裕丈, 磯貝 里奈, 野口 健, 堀田 彰悟, 吉見 陽, 尾崎 紀夫, 山田 清文, 野田 幸裕

    医療薬学   Vol. 48 ( 9 ) page: 359 - 367   2022.9

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    当院における抗うつ薬や抗不安薬の適正使用を推進するため、1997年、2003年、2005年、2007年、2013年、2015年、2018年の精神科および親と子どもの心療科における抗うつ薬、抗不安薬の処方状況を調査した。各年の代表を5日間として無作為に抽出し、対象患者2780名の年齢、性別、処方内容を集計した。各年とも精神科外来患者の約30~50%が抗うつ薬を服用しており、新規抗うつ薬の単剤処方は抗うつ薬の十分量相当にて処方されていた。抗うつ薬服用患者における抗不安薬の併用率とジアゼパム換算値は年々減少しており、抗精神病薬の併用削減が進んでいると考えられた。抗うつ薬の適正使用の推進に向けて、単剤処方、特に新規抗うつ薬の単剤処方と併用処方の有用性や安全性を比較し、新規抗うつ薬単剤処方の優越性について検討する必要性が示唆された。

  46. Functional connector hubs in the cerebellum International journal

    Kazuya Kawabata, Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Reiko Ohdake, Michihito Masuda, Aya Ogura, Toshiyasu Kato, Shuji Koyama, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

    NeuroImage   Vol. 257   page: 119263 - 119263   2022.8

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    Accumulating evidence from anatomical and neuroimaging studies suggests that the cerebellum is engaged in a variety of motor and cognitive tasks. Given its various functions, a key question is whether the cerebellum also plays an important role in the brain's integrative functions. Here, we hypothesize the existence of connector regions, also known as connector hubs, where multiple resting state networks converged in the cerebellum. To verify this, we employed a recently developed voxel-level network measure called functional connectivity overlap ratio (FCOR), which could be used to quantify the spatial extent of a region's connection to several large-scale cortical networks. Using resting state functional MRI data from 101 healthy participants, cerebellar FCOR maps were constructed and used to identify the locations of connector hubs in the cerebellum. Results showed that a number of cerebellar regions exhibited strong connectivity with multiple functional networks, verifying our hypothesis. These highly connected regions were located in the posterior cerebellum, especially in lobules VI, VII, and IX, and mainly connected to the core neurocognitive networks such as default mode and executive control networks. Regions associated with the sensorimotor network were also localized in lobule V, VI, and VIII, albeit in small clusters. These cerebellar connector hubs may play an essential role in the processing of information across the core neurocognitive networks.

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  47. Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach - CORRIGENDUM. International journal

    Micah Cearns, Azmeraw T Amare, Klaus Oliver Schubert, Anbupalam Thalamuthu, Joseph Frank, Fabian Streit, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, JeanMichel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, HsiChung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M Czerski, Nina Dalkner, Alexandre Dayer, Franziska Degenhardt, Maria Del Zompo, J Raymond DePaulo, Bruno Étain, Peter Falkai, Andreas J Forstner, Louise Frisen, Mark A Frye, Janice M Fullerton, Sébastien Gard, Julie S Garnham, Fernando S Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Andrea Hofmann, Liping Hou, Yi-Hsiang Hsu, Stephane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Markus M Nöthen, Tomas Novák, Claire O'Donovan, Norio Ozaki, Vincent Millischer, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B Potash, Andreas Reif, Eva Reininghaus, Guy A Rouleau, Janusz K Rybakowski, Martin Schalling, Peter R Schofield, Barbara W Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fasil TekolaAyele, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Stephanie H Witt, Gloria Roberts, Peter P Zandi, Martin Alda, Michael Bauer, Francis J McMahon, Philip B Mitchell, Thomas G Schulze, Marcella Rietschel, Scott R Clark, Bernhard T Baune

    The British journal of psychiatry : the journal of mental science   Vol. 221 ( 2 ) page: 494 - 494   2022.8

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    DOI: 10.1192/bjp.2022.55

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  48. ドライビングシミュレーターによる健常者の運転技能と視線特性との関係性

    田中 陽子, 宮田 聖子, 岩本 邦弘, 山本 真江里, 三浦 健一郎, 橋本 亮太, 尾崎 紀夫

    日本安全運転医療学会誌   Vol. 2 ( 1 ) page: 46 - 53   2022.8

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    道路交通法により体調不良時の自動車運転は禁止されているが,患者に運転の可否を指導する上での医学的なエビデンスは乏しく,適切な指導のもと患者が自動車社会で生活するためには,運転技能に関わる医学的知見を蓄積することが求められる.運転技能に必須である視覚,認知機能,運動機能の中でも,とりわけ視覚情報は運転中に得られる情報の90%にも及び,視覚を支える視線を促えることが運転技能を予測する上で有用な可能性がある.そこで,本研究では,視線の基本的特性と運転技能との関連にっいて検討を行うため,同一被験者にて運転と視線計測を行った健常者36名を対象に運転と視線の関連にっいて解折した.運転課題は車線維持課題(横揺れの指標),急ブレーキ課題(反応時間の指標)を実施し,視線課題では,フリービューイング課題,固視課題,パシュート課題を実施した.運転の指標と視線の指標との相関解析により,横揺れの指標はフリービュ一イング課題におけるフィクセーション,サッケード関連指標,視線移動の総距離,およびパシュート課題におけるサッケード,垂直方向の視線移動に関する指標と有意な相関を示した.また,反応時間の指標はパシュート課題におけるサッケー一ドおよび垂直方向の視線移動の指標と有意な相関を示した.以上より,視線解析におけるサッケードや視線移動距離といった指標は,運転技能を予測できる可能性が示された.(著者抄録)

  49. The genetic architecture of schizophrenia: review of large-scale genetic studies

    Hidekazu Kato, Hiroki Kimura, Itaru Kushima, Nagahide Takahashi, Branko Aleksic, Norio Ozaki

    Journal of Human Genetics   Vol. 68 ( 3 ) page: 175 - 182   2022.7

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    DOI: 10.1038/s10038-022-01059-4

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  50. Correction: Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients. International journal

    Klaus Oliver Schubert, Anbupalam Thalamuthu, Azmeraw T Amare, Joseph Frank, Fabian Streit, Mazda Adl, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M Biernacka, Armin Birner, Cynthia Marie-Claire, Micah Cearns, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Scott R Clark, Cristiana Cruceanu, Piotr M Czerski, Nina Dalkner, Alexandre Dayer, Franziska Degenhardt, Maria Del Zompo, J Raymond DePaulo, Bruno Étain, Peter Falkai, Andreas J Forstner, Louise Frisen, Mark A Frye, Janice M Fullerton, Sébastien Gard, Julie S Garnham, Fernando S Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Liping Hou, Yi-Hsiang Hsu, Stephane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Markus M Nöthen, Tomas Novák, Claire O'Donovan, Norio Ozaki, Urban Ösby, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B Potash, Andreas Reif, Eva Reininghaus, Guy A Rouleau, Janusz K Rybakowski, Martin Schalling, Peter R Schofield, Barbara W Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fasil Tekola-Ayele, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Stephanie H Witt, Gloria Roberts, Peter P Zandi, Martin Alda, Michael Bauer, Francis J McMahon, Philip B Mitchell, Thomas G Schulze, Marcella Rietschel, Bernhard T Baune

    Translational psychiatry   Vol. 12 ( 1 ) page: 278 - 278   2022.7

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    DOI: 10.1038/s41398-022-02037-2

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  51. Exome sequencing analysis of Japanese autism spectrum disorder case-control sample supports an increased burden of synaptic function-related genes International journal

    Hiroki Kimura, Masahiro Nakatochi, Branko Aleksic, James Guevara, Miho Toyama, Yu Hayashi, Hidekazu Kato, Itaru Kushima, Mako Morikawa, Kanako Ishizuka, Takashi Okada, Yoshinori Tsurusaki, Atsushi Fujita, Noriko Miyake, Tomoo Ogi, Atsushi Takata, Naomichi Matsumoto, Joseph Buxbaum, Norio Ozaki, Jonathan Sebat

    Translational Psychiatry   Vol. 12 ( 1 ) page: 265 - 265   2022.7

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    Abstract

    Autism spectrum disorder (ASD) is a highly heritable, complex disorder in which rare variants contribute significantly to disease risk. Although many genes have been associated with ASD, there have been few genetic studies of ASD in the Japanese population. In whole exomes from a Japanese ASD sample of 309 cases and 299 controls, rare variants were associated with ASD within specific neurodevelopmental gene sets, including highly constrained genes, fragile X mental retardation protein target genes, and genes involved in synaptic function, with the strongest enrichment in trans-synaptic signaling (p = 4.4 × 10<sup>−4</sup>, Q-value = 0.06). In particular, we strengthen the evidence regarding the role of ABCA13, a synaptic function-related gene, in Japanese ASD. The overall results of this case-control exome study showed that rare variants related to synaptic function are associated with ASD susceptibility in the Japanese population.

    DOI: 10.1038/s41398-022-02033-6

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    Other Link: https://www.nature.com/articles/s41398-022-02033-6

  52. Polysomnographic characteristics and predictors of positional obstructive sleep apnea in Japanese elderly

    Miyata Seiko, Otake Hironao, Fujishiro Hiroshige, Iwamoto Kunihiro, Noda Akiko, Sone Michihiko, Ozaki Norio

    SLEEP AND BIOLOGICAL RHYTHMS   Vol. 20 ( 3 ) page: 403 - 411   2022.7

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    DOI: 10.1007/s41105-022-00385-6

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  53. Treatment-resistant schizophrenia in patients with 3q29 deletion: A case series of four patients. International journal

    Yoshihiro Nawa, Itaru Kushima, Branko Aleksic, Maeri Yamamoto, Hiroyuki Kimura, Masahiro Banno, Ryota Hashimoto, Norio Ozaki

    Psychiatry and clinical neurosciences   Vol. 76 ( 7 ) page: 338 - 339   2022.7

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    DOI: 10.1111/pcn.13361

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  54. Striatal <sup>123</sup> I‐2β‐carbomethoxy‐3b‐(4‐iodophenyl)‐N‐(3‐fluoropropyl)‐nortropane single‐photon emission computed tomography demonstrates nigral degeneration in the early stage of behavioural variant frontotemporal dementia: an autopsy case with frontotemporal lobar degeneration with trans‐activation response DNA protein 43 type B International journal

    Shusei Arafuka, Hiroshige Fujishiro, Shuji Iritani, Youta Torii, Ayako Miwa, Hiroyuki Yabata, Hirotaka Sekiguchi, Chikako Habuchi, Kunihiro Kawashima, Mari Yoshida, Yasushi Iwasaki, Norio Ozaki

    Psychogeriatrics   Vol. 22 ( 4 ) page: 580 - 585   2022.7

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    DOI: 10.1111/psyg.12842

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/psyg.12842

  55. Psychiatric patients with a de novo 17q12 deletion: two case reports. International journal

    Itaru Kushima, Mariko Uematsu, Kanako Ishizuka, Branko Aleksic, Norio Ozaki

    Psychiatry and clinical neurosciences   Vol. 76 ( 7 ) page: 345 - 347   2022.7

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    DOI: 10.1111/pcn.13367

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  56. Prevalence, clinical features, and risk factors of delusions in patients with delirium. International journal

    Masako Tachibana, Toshiya Inada, Masaru Ichida, Norio Ozaki

    International journal of geriatric psychiatry   Vol. 37 ( 6 )   2022.6

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    OBJECTIVES: Delirium may be divided into multiple subtypes with different pathological factors. This study aimed to focus on the delirium subtype in which delusions are conspicuous and explore its prevalence, clinical characteristics, and risk factors. METHODS: The subjects were 601 delirium cases referred to the department of psychiatry over 5 years at a general hospital. The Delirium Rating Scale-Revised-98 was used to assess the delusions in patients with delirium, and the features of delusions (delusional form, object, and content) were examined. Multiple regression analysis was applied to determine whether individual factors were associated with the delusions. RESULTS: A total of 78 patients with delirium experienced delusions (13.0%). Most were classified as delusion of reference, such as persecution or poisoning, and 84.3% of patients believed that the persecutors were medical staff members. Older age (p < 0.001), female gender (p < 0.001), and living alone (p < 0.001) were significantly associated with delusions in patients with delirium. CONCLUSIONS: The content of delusions was rooted in the distress caused by the patients' medical situation, and the features and risk factors of the delusions suggested a formal similarity with late paraphrenia and "lack-of-contact paranoia." Psychological interventions that consider the isolation, anxiety, and fear behind delusions may be necessary in the care and treatment of these patients.

    DOI: 10.1002/gps.5763

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  57. Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology International journal

    Koyo Tsujikawa, Kohei Hamanaka, Yuichi Riku, Yuki Hattori, Norikazu Hara, Yohei Iguchi, Shinsuke Ishigaki, Atsushi Hashizume, Satoko Miyatake, Satomi Mitsuhashi, Yu Miyazaki, Mayumi Kataoka, Li Jiayi, Keizo Yasui, Satoshi Kuru, Haruki Koike, Kenta Kobayashi, Naruhiko Sahara, Norio Ozaki, Mari Yoshida, Akiyoshi Kakita, Yuko Saito, Yasushi Iwasaki, Akinori Miyashita, Takeshi Iwatsubo, Takeshi Ikeuchi, Takaki Miyata, Gen Sobue, Naomichi Matsumoto, Kentaro Sahashi, Masahisa Katsuno

    Science Advances   Vol. 8 ( 21 ) page: eabm5029   2022.5

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    While amyloid-β lies upstream of tau pathology in Alzheimer’s disease, key drivers for other tauopathies, including progressive supranuclear palsy (PSP), are largely unknown. Various tau mutations are known to facilitate tau aggregation, but how the nonmutated tau, which most cases with PSP share, increases its propensity to aggregate in neurons and glial cells has remained elusive. Here, we identified genetic variations and protein abundance of filamin-A in the PSP brains without tau mutations. We provided in vivo biochemical evidence that increased filamin-A levels enhance the phosphorylation and insolubility of tau through interacting actin filaments. In addition, reduction of filamin-A corrected aberrant tau levels in the culture cells from PSP cases. Moreover, transgenic mice carrying human filamin-A recapitulated tau pathology in the neurons. Our data highlight that filamin-A promotes tau aggregation, providing a potential mechanism by which filamin-A contributes to PSP pathology.

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  58. Driving performance of euthymic outpatients with bipolar disorder undergoing real-world pharmacotherapy. International journal

    Akiko Yamaguchi, Kunihiro Iwamoto, Masahiko Ando, Kiyoshi Fujita, Motonori Yokoyama, Tsuyoshi Akiyama, Yoshio Igarashi, Norio Ozaki

    Psychiatry and clinical neurosciences   Vol. 76 ( 5 ) page: 172 - 178   2022.5

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    OBJECTIVE: Medications for the treatment of bipolar disorder (BD) could affect patients' cognitive function. Patients with BD present with neurocognitive impairment even in a remission state. Little research is available on the daily functioning, especially driving performance, of stable outpatients with BD under pharmacological treatment. METHODS: In total, 58 euthymic outpatients with BD undergoing real-world pharmacotherapy and 80 sex- and age-matched healthy controls (HCs) were enrolled. Three driving tasks using a driving simulator-road-tracking, car-following, and harsh-braking-and three cognitive tasks-Continuous Performance Test, Wisconsin Card Sorting Test, and Trail-Making Test-were evaluated. Symptom assessment scales-Young Mania Rating Scale, Structured Interview Guide for the Hamilton Depression Rating Scale, Beck Depression Inventory-II, Social Adaptation Self-evaluation Scale, and Stanford Sleepiness Scale-were also completed. RESULTS: Car-following and road-tracking performance were significantly impaired in patients with BD compared with HCs after adjusting for demographic variables, but these performances generally overlapped. Broad neurocognitive functions were significantly lower in the patients with BD compared to HCs, but car-following performance was significantly negatively correlated with sustained attention only. Although most patients received multiple medications rather than monotherapy, no relationship between prescriptions and driving performance was found. CONCLUSION: Euthymic patients with BD under steady-state pharmacotherapy had impaired driving performance compared with HCs, but the overlapping distributions of driving performance suggested that driving performance is not always deteriorated in patients with BD. Therefore, attentional function may be a useful clinical feature for judging driving aptitude in patients with BD. This article is protected by copyright. All rights reserved.

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  59. Investigation of OLIG2 as a candidate gene for schizophrenia and autism spectrum disorder.

    Sho Furuta, Branko Aleksic, Yoshihiro Nawa, Hiroki Kimura, Itaru Kushima, Kanako Ishizuka, Hidekazu Kato, Miho Toyama, Yuko Arioka, Daisuke Mori, Mako Morikawa, Toshiya Inada, Norio Ozaki

    Nagoya journal of medical science   Vol. 84 ( 2 ) page: 260 - 268   2022.5

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    A number of genomic mutations that are thought to be strongly involved in the development of schizophrenia (SCZ) and autism spectrum disorder (ASD) have been identified. Abnormalities involving oligodendrocytes have been reported in SCZ, and as a related gene, oligodendrocyte lineage transcription factor 2 (OLIG2) has been reported to be strongly associated with SCZ. In this study, based on the common disease-rare variant hypothesis, target sequencing of candidate genes was performed to identify rare mutations with a high effect size and the possibility that the identified mutations may increase the risks of SCZ and ASD in the Japanese population. In this study, the exon region of OLIG2 was targeted; 370 patients with SCZ and 192 with ASD were subjected to next-generation sequencing. As a result, one rare missense mutation (A33T) was detected. We used the Sanger method to validate this missense mutation with a low frequency (<1%), and then carried out a genetic association analysis involving 3299 unrelated individuals (1447 with SCZ, 380 with ASD, and 1472 healthy controls) to clarify whether A33T was associated with SCZ or ASD. A33T was not found in either case group, and in only one control. We did not find evidence that p.A33T is involved in the onset of ASD or SCZ; however, associations with this variant need to be evaluated in larger samples to confirm our results.

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  60. Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial International journal

    Hidenori Yamasue, Masaki Kojima, Hitoshi Kuwabara, Miho Kuroda, Kaori Matsumoto, Chieko Kanai, Naoko Inada, Keiho Owada, Keiko Ochi, Nobutaka Ono, Seico Benner, Tomoyasu Wakuda, Yosuke Kameno, Jun Inoue, Taeko Harada, Kenji Tsuchiya, Kazuo Umemura, Aya Yamauchi, Nanayo Ogawa, Itaru Kushima, Norio Ozaki, Satoshi Suyama, Takuya Saito, Yukari Uemura, Junko Hamada, Yukiko Kano, Nami Honda, Saya Kikuchi, Moe Seto, Hiroaki Tomita, Noriko Miyoshi, Megumi Matsumoto, Yuko Kawaguchi, Koji Kanai, Manabu Ikeda, Itta Nakamura, Shuichi Isomura, Yoji Hirano, Toshiaki Onitsuka, Hirotaka Kosaka, Takashi Okada

    Brain   Vol. 145 ( 2 ) page: 490 - 499   2022.4

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    Abstract

    Although intranasal oxytocin is expected to be a novel therapy for the core symptoms of autism spectrum disorder, which has currently no approved medication, the efficacy of repeated administrations was inconsistent, suggesting that the optimal dose for a single administration of oxytocin is not optimal for repeated administration.

    The current double-blind, placebo-controlled, multicentre, crossover trial (ClinicalTrials.gov Identifier: NCT03466671) was aimed to test the effect of TTA-121, a new formulation of intranasal oxytocin spray with an enhanced bioavailability (3.6 times higher than Syntocinon® spray, as assessed by area under the concentration–time curve in rabbit brains), which enabled us to test a wide range of multiple doses, on autism spectrum disorder core symptoms and to determine the dose–response relationship. Four-week administrations of TTA-121, at low dose once per day (3 U/day), low dose twice per day (6 U/day), high dose once per day (10 U/day), or high dose twice per day (20 U/day), and 4-week placebo were administered in a crossover manner. The primary outcome was the mean difference in the reciprocity score (range: 0–14, higher values represent worse outcomes) on the Autism Diagnostic Observation Schedule between the baseline and end point of each administration period. This trial with two administration periods and eight groups was conducted at seven university hospitals in Japan, enrolling adult males with high-functioning autism spectrum disorder. Enrolment began from June 2018 and ended December 2019. Follow-up ended March 2020.

    Of 109 males with high-functioning autism spectrum disorder who were randomized, 103 completed the trial. The smallest P-value, judged as the dose–response relationship, was the contrast with the peak at TTA-121 6 U/day, with inverted U-shape for both the full analysis set (P = 0.182) and per protocol set (P = 0.073). The Autism Diagnostic Observation Schedule reciprocity score, the primary outcome, was reduced in the TTA-121 6 U/day administration period compared with the placebo (full analysis set: P = 0.118, mean difference = −0.5; 95% CI: −1.1 to 0.1; per protocol set: P = 0.012, mean difference = −0.8; 95% CI: −1.3 to −0.2). The per protocol set was the analysis target population, consisting of all full analysis set participants except those who deviated from the protocol. Most dropouts from the full analysis set to the per protocol set occurred because of poor adherence to the test drug (9 of 12 in the first period and 8 of 15 in the second period). None of the secondary clinical and behavioural outcomes were significantly improved with the TTA-121 compared with the placebo in the full analysis set.

    A novel intranasal spray of oxytocin with enhanced bioavailability enabled us to test a wide range of multiple doses, revealing an inverted U-shape dose–response curve, with the peak at a dose that was lower than expected from previous studies. The efficacy of TTA-121 shown in the current exploratory study should be verified in a future large-scale, parallel-group trial.

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    Other Link: https://academic.oup.com/brain/article-pdf/145/2/490/43402326/awab291.pdf

  61. Correction to: Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome. International journal

    Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

    Molecular brain   Vol. 15 ( 1 ) page: 34 - 34   2022.4

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    DOI: 10.1186/s13041-022-00920-z

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  62. Atezolizumab, an immune checkpoint inhibitor, caused precedent depressive symptoms related to limbic encephalitis

    Wada Shuhei, Iwamoto Kunihiro, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 76 ( 4 ) page: 125 - 126   2022.4

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    DOI: 10.1111/pcn.13325

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  63. Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach International journal

    Micah Cearns, Azmeraw T. Amare, Klaus Oliver Schubert, Anbupalam Thalamuthu, Joseph Frank, Fabian Streit, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, B{\'{a } }rbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alex, re Dayer, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Bruno {\'{E } }tain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, S{\'{e } }bastien Gard, Julie S. Garnham, Fern, o S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Andrea Hofmann, Liping Hou, Yi-Hsiang Hsu, Stephane Jamain, Esther Jim{\'{e } }nez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael L, {\'{e } }n, Catharina Lavebratt, Marion Leboyer, Susan G. Leckb, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nöthen, Tomas Nov{\'{a } }k, Claire O{\textquotesingle}Donovan, Norio Ozaki, Vincent Millischer, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Katzutaka Shimoda, Christian Simh, l, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fasil Tekola-Ayele, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Stephanie H. Witt, Gloria Roberts, Peter P. Z, i, Martin Alda, Michael Bauer, Francis J. McMahon, Philip B. Mitchell, Thomas G. Schulze, Marcella Rietschel, Scott R. Clark, Bernhard T. Baune

    The British Journal of Psychiatry   Vol. 220 ( 4 ) page: 219 - 228   2022.4

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    <jats:sec id="S0007125022000289_sec_a1">
    <jats:title>Background</jats:title>
    <jats:p>Response to lithium in patients with bipolar disorder is associated with clinical and transdiagnostic genetic factors. The predictive combination of these variables might help clinicians better predict which patients will respond to lithium treatment.</jats:p>
    </jats:sec>
    <jats:sec id="S0007125022000289_sec_a2">
    <jats:title>Aims</jats:title>
    <jats:p>To use a combination of transdiagnostic genetic and clinical factors to predict lithium response in patients with bipolar disorder.</jats:p>
    </jats:sec>
    <jats:sec id="S0007125022000289_sec_a3" sec-type="methods">
    <jats:title>Method</jats:title>
    <jats:p>This study utilised genetic and clinical data (<jats:italic>n</jats:italic> = 1034) collected as part of the International Consortium on Lithium Genetics (ConLi<jats:sup>+</jats:sup>Gen) project. Polygenic risk scores (PRS) were computed for schizophrenia and major depressive disorder, and then combined with clinical variables using a cross-validated machine-learning regression approach. Unimodal, multimodal and genetically stratified models were trained and validated using ridge, elastic net and random forest regression on 692 patients with bipolar disorder from ten study sites using leave-site-out cross-validation. All models were then tested on an independent test set of 342 patients. The best performing models were then tested in a classification framework.</jats:p>
    </jats:sec>
    <jats:sec id="S0007125022000289_sec_a4" sec-type="results">
    <jats:title>Results</jats:title>
    <jats:p>The best performing linear model explained 5.1% (<jats:italic>P</jats:italic> = 0.0001) of variance in lithium response and was composed of clinical variables, PRS variables and interaction terms between them. The best performing non-linear model used only clinical variables and explained 8.1% (<jats:italic>P</jats:italic> = 0.0001) of variance in lithium response. <jats:italic>A priori</jats:italic> genomic stratification improved non-linear model performance to 13.7% (<jats:italic>P</jats:italic> = 0.0001) and improved the binary classification of lithium response. This model stratified patients based on their meta-polygenic loadings for major depressive disorder and schizophrenia and was then trained using clinical data.</jats:p>
    </jats:sec>
    <jats:sec id="S0007125022000289_sec_a5" sec-type="conclusions">
    <jats:title>Conclusions</jats:title>
    <jats:p>Using PRS to first stratify patients genetically and then train machine-learning models with clinical predictors led to large improvements in lithium response prediction. When used with other PRS and biological markers in the future this approach may help inform which patients are most likely to respond to lithium treatment.</jats:p>
    </jats:sec>

    DOI: 10.1192/bjp.2022.28

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  64. Case report of a female with bipolar disorder and <scp> <i>MBD5</i> </scp> deletion

    Itaru Kushima, Tzuyao Lo, Branko Aleksic, Norio Ozaki

    Psychiatry and Clinical Neurosciences   Vol. 76 ( 4 ) page: 127 - 128   2022.4

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    DOI: 10.1111/pcn.13329

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pcn.13329

  65. 【精神科ブレインバンク】ゲノム解析研究とブレインバンク

    荒深 周生, 鳥居 洋太, 尾崎 紀夫

    精神科   Vol. 40 ( 4 ) page: 422 - 429   2022.4

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  66. Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome International journal

    Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

    Molecular Brain   Vol. 15 ( 1 ) page: 26 - 26   2022.3

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    Abstract

    Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by specific social symptoms, restricted interests, stereotyped repetitive behaviors, and delayed language development. The 3q29 microdeletion (3q29del), a recurrent copy number variant, confers a high risk for ASD and schizophrenia, and serves as an important pathological model for investigating the molecular pathogenesis of a large number of neurodevelopmental and psychiatric conditions. Recently, mouse models carrying a deletion of the chromosomal region corresponding to the human 3q29 region (Df/+ mice) were generated and demonstrated neurodevelopmental and psychiatric conditions associated behavioral abnormalities, pointing to the relevance of Df/+ mice as a model for these conditions with high construct and face validity. Currently, the molecular pathogenesis of these behavioral phenotypes in Df/+ mice remains unclear. The oxytocin (OXT) system plays a central role in social behavior across species and has a potential role in ASD. In this study, to elucidate the molecular mechanisms behind impaired social behavior in Df/+ mice, we investigated the possible involvement of OXT signaling in impaired social behavior in Df/+ mice. We demonstrated that OXT administration restored the impaired social behavior in Df/+ mice. We also demonstrated that the number of OXT-positive cells in the paraventricular nucleus (PVN) was significantly lower in Df/+ mice than in wild-type (WT) littermates. Consistent with this, the level of OXT peptide in the cerebral cortex of Df/+ mice was lower than in WT littermates. Our study may provide important insights into the molecular pathophysiological basis of neurodevelopmental and psychiatric conditions, including ASD.

    DOI: 10.1186/s13041-022-00915-w

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    Other Link: https://link.springer.com/article/10.1186/s13041-022-00915-w/fulltext.html

  67. Duloxetine attenuates pain in association with downregulation of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia.

    Nakamura M, Yoshimi A, Mouri A, Tokura T, Kimura H, Kishi S, Miyauchi T, Iwamoto K, Ito M, Sato-Boku A, Ozaki N, Nabeshima T, Noda Y

    Human psychopharmacology   Vol. 37 ( 2 ) page: e2818   2022.3

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    DOI: 10.1002/hup.2818

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  68. Variable psychiatric manifestations in patients with 16p11.2 duplication: a case series of 4 patients

    Yu Hayashi, Itaru Kushima, Branko Aleksic, Tetsu Senaha, Norio Ozaki

    Psychiatry and Clinical Neurosciences   Vol. 76 ( 3 ) page: 86 - 88   2022.3

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    DOI: 10.1111/pcn.13324

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pcn.13324

  69. Severe and long-lasting neuropsychiatric symptoms after mild respiratory symptoms caused by COVID-19: A case report. International journal

    Ryosuke Jozuka, Hiroki Kimura, Takashi Uematsu, Hidetsugu Fujigaki, Yasuko Yamamoto, Masato Kobayashi, Kazuya Kawabata, Haruki Koike, Toshiya Inada, Kuniaki Saito, Masahisa Katsuno, Norio Ozaki

    Neuropsychopharmacology reports   Vol. 42 ( 1 ) page: 114 - 119   2022.3

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    BACKGROUND: Coronavirus disease 2019 (COVID-19) is known to cause not only respiratory but also neuropsychiatric symptoms, which are assumed to be derived from a cytokine storm and its effects on the central nervous systems. Patients with COVID-19 who develop severe respiratory symptoms are known to show severe neuropsychiatric symptoms such as cerebrovascular disease and encephalopathy. However, the detailed clinical courses of patients with neuropsychiatric symptoms caused by mild or asymptomatic COVID-19 remain poorly understood. Here, we present a case of COVID-19 who presented with severe and prolonged neuropsychiatric symptoms subsequent to mild respiratory symptoms. CASE PRESENTATION: A 55-year-old female with COVID-19 accompanied by mild respiratory symptoms showed delusion, psychomotor excitement, and poor communication ability during quarantine outside the hospital. Considering her diminished respiratory symptoms, her neuropsychiatric symptoms were initially regarded as psychogenic reactions. However, as she showed progressive disturbance of consciousness accompanied by an abnormal electroencephalogram, she was diagnosed with post-COVID-19 encephalopathy. Although her impaired consciousness and elevated cytokine level improved after steroid pulse therapy, several neuropsychiatric symptoms, including a loss of concentration, unsteadiness while walking, and fatigue, remained. CONCLUSIONS: This case suggests the importance of both recognizing that even apparently mild COVID-19-related respiratory symptoms can lead to severe and persistent neuropsychiatric symptoms, and elucidating the mechanisms, treatment, and long-term course of COVID-19-related neuropsychiatric symptoms in the future.

    DOI: 10.1002/npr2.12222

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  70. Residual effects of zopiclone on driving performance using a standardized driving simulator among healthy volunteers. International journal

    Kunihiro Iwamoto, Mari Iwata, Daiji Kambe, Yumiko Imadera, Naoki Tachibana, Yu Kajiyama, Masahiko Ando, Norio Ozaki

    Psychopharmacology   Vol. 239 ( 3 ) page: 841 - 850   2022.3

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    RATIONALE: The effects of hypnotics on automobile driving have been attracting increasing attention. However, few driving simulators (DSs) have been confirmed to have acceptable reliability and validity for assessing the next-day residual effects of zopiclone as a positive control on driving performance. OBJECTIVE: To investigate whether a new DS could permit detection of the next-day residual effects of zopiclone on driving performance. METHODS: In this double-blind, randomized, placebo-controlled crossover trial, 28 healthy males received zopiclone 7.5 mg at bedtime on days 1 and 8 and placebo on the other days over a period of 16 days. The participants took part in three driving tasks-road-tracking, car-following, and harsh-braking-using a DS on days 2 and 9 at 9-h post-dosing. Scores on the Karolinska Sleepiness Scale and Profile of Mood States-Second Edition were then assessed, as was the serum concentration of zopiclone. RESULTS: The estimated differences in the standard deviation of lateral position (cm) in the road-tracking task between the zopiclone and placebo groups on days 2 and 9 were 3.75 cm (90% confidence interval (CI): 1.71-5.79) and 4.07 cm (90% CI: 2.02-6.11), respectively. The estimated differences in the distance coefficient of variation in the car-following task and in the brake reaction time in the harsh-braking task between the zopiclone and placebo groups on day 2 were 4.31 (90% CI: 1.94-6.69) and 24.6 ms (90% CI: 12.7-36.4), respectively. CONCLUSIONS: The DS used in this study has sufficient sensitivity to detect the next-day residual effects of zopiclone on driving performance.

    DOI: 10.1007/s00213-022-06075-y

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  71. 脳内免疫系及び神経形態における幼若期の心理社会的ストレス負荷の影響

    吉田 樹生, 鈴木 千晴, 濱田 眞理亜, 肥田 裕丈, 毛利 彰宏, 吉見 陽, 尾崎 紀夫, 野田 幸裕

    日本薬学会年会要旨集   Vol. 142年会   page: 28PO9 - 03S   2022.3

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  72. 統合失調症入院患者における抗精神病薬の処方状況と減量・減薬の実態調査 多剤併用療法の解消に向けて

    松本 あおい, 中村 真理子, 吉見 陽, 肥田 裕丈, 堀田 彰悟, 尾崎 紀夫, 山田 清文, 野田 幸裕

    日本薬学会年会要旨集   Vol. 142年会   page: 26PO1 - 30S   2022.3

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  73. Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder. International journal

    Chenyao Wang, Shin-Ichiro Horigane, Minoru Wakamori, Shuhei Ueda, Takeshi Kawabata, Hajime Fujii, Itaru Kushima, Hiroki Kimura, Kanako Ishizuka, Yukako Nakamura, Yoshimi Iwayama, Masashi Ikeda, Nakao Iwata, Takashi Okada, Branko Aleksic, Daisuke Mori, Takashi Yoshida, Haruhiko Bito, Takeo Yoshikawa, Sayaka Takemoto-Kimura, Norio Ozaki

    Translational psychiatry   Vol. 12 ( 1 ) page: 84 - 84   2022.2

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    Several large-scale whole-exome sequencing studies in patients with schizophrenia (SCZ) and autism spectrum disorder (ASD) have identified rare variants with modest or strong effect size as genetic risk factors. Dysregulation of cellular calcium homeostasis might be involved in SCZ/ASD pathogenesis, and genes encoding L-type voltage-gated calcium channel (VGCC) subunits Cav1.1 (CACNA1S), Cav1.2 (CACNA1C), Cav1.3 (CACNA1D), and T-type VGCC subunit Cav3.3 (CACNA1I) recently were identified as risk loci for psychiatric disorders. We performed a screening study, using the Ion Torrent Personal Genome Machine (PGM), of exon regions of these four candidate genes (CACNA1C, CACNA1D, CACNA1S, CACNA1I) in 370 Japanese patients with SCZ and 192 with ASD. Variant filtering was applied to identify biologically relevant mutations that were not registered in the dbSNP database or that have a minor allele frequency of less than 1% in East-Asian samples from databases; and are potentially disruptive, including nonsense, frameshift, canonical splicing site single nucleotide variants (SNVs), and non-synonymous SNVs predicted as damaging by five different in silico analyses. Each of these filtered mutations were confirmed by Sanger sequencing. If parental samples were available, segregation analysis was employed for measuring the inheritance pattern. Using our filter, we discovered one nonsense SNV (p.C1451* in CACNA1D), one de novo SNV (p.A36V in CACNA1C), one rare short deletion (p.E1675del in CACNA1D), and 14 NSstrict SNVs (non-synonymous SNV predicted as damaging by all of five in silico analyses). Neither p.A36V in CACNA1C nor p.C1451* in CACNA1D were found in 1871 SCZ cases, 380 ASD cases, or 1916 healthy controls in the independent sample set, suggesting that these SNVs might be ultra-rare SNVs in the Japanese population. The neuronal splicing isoform of Cav1.2 with the p.A36V mutation, discovered in the present study, showed reduced Ca2+-dependent inhibition, resulting in excessive Ca2+ entry through the mutant channel. These results suggested that this de novo SNV in CACNA1C might predispose to SCZ by affecting Ca2+ homeostasis. Thus, our analysis successfully identified several ultra-rare and potentially disruptive gene variants, lending partial support to the hypothesis that VGCC-encoding genes may contribute to the risk of SCZ/ASD.

    DOI: 10.1038/s41398-022-01851-y

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  74. Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in ASD patients from the Japanese population

    Tzuyao Lo, Itaru Kushima, Branko Aleksic, Hidekazu Kato, Yoshihiro Nawa, Yu Hayashi, Gantsooj Otgonbayar, Hiroki Kimura, Yuko Arioka, Daisuke Mori, Norio Ozaki

    International Review of Psychiatry   Vol. 34 ( 2 ) page: 154 - 167   2022.2

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    DOI: 10.1080/09540261.2022.2072193

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  75. High-power laser experiment forming a supercritical collisionless shock in a magnetized uniform plasma at rest

    Yamazaki R., Matsukiyo S., Morita T., Tanaka S. J., Umeda T., Aihara K., Edamoto M., Egashira S., Hatsuyama R., Higuchi T., Hihara T., Horie Y., Hoshino M., Ishii A., Ishizaka N., Itadani Y., Izumi T., Kambayashi S., Kakuchi S., Katsuki N., Kawamura R., Kawamura Y., Kisaka S., Kojima T., Konuma A., Kumar R., Minami T., Miyata I, Moritaka T., Murakami Y., Nagashima K., Nakagawa Y., Nishimoto T., Nishioka Y., Ohira Y., Ohnishi N., Ota M., Ozaki N., Sano T., Sakai K., Sei S., Shiota J., Shoji Y., Sugiyama K., Suzuki D., Takagi M., Toda H., Tomita S., Tomiya S., Yoneda H., Takezaki T., Tomita K., Kuramitsu Y., Sakawa Y.

    PHYSICAL REVIEW E   Vol. 105 ( 2 ) page: 025203   2022.2

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    DOI: 10.1103/PhysRevE.105.025203

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  76. Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses

    Janos L. Kalman, Tomoya Yoshida, Till F. M. Andlauer, Eva C. Schulte, Kristina Adorjan, Martin Alda, Raffaela Ardau, Jean-Michel Aubry, Katharina Brosch, Monika Budde, Caterina Chillotti, Piotr M. Czerski, Raymond J. DePaulo, Andreas Forstner, Fern, o S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Dominik Grotegerd, Tim Hahn, Maria Heilbronner, Rol, Hasler, Urs Heilbronner, Stefanie Heilmann-Heimbach, Pawel Kapelski, Tadafumi Kato, Mojtaba Oraki Kohshour, Susanne Meinert, Tina Meller, Igor Nenadi{\'{c } }, Markus M. Nöthen, Tomas Novak, Nils Opel, Joanna Pawlak, Julia-Katharina Pfarr, James B. Potash, Daniela Reich-Erkelenz, Jonathan Repple, H{\'{e } }l{\`{e } }ne Richard-Lepouriel, Marcella Rietschel, Kai G. Ringwald, Guy Rouleau, Sabrina Schaupp, Fanny Senner, Giovanni Severino, Alessio Squassina, Frederike Stein, Pavla Stopkova, Fabian Streit, Katharina Thiel, Florian Thomas-Odenthal, Gustavo Turecki, Joanna Twarowska-Hauser, Alex, ra Winter, Peter P. Z, i, John R. Kelsoe, Bernhard T. Baune, Jan Fullerton, Philip B. Mitchell, Peter R. Schofield, Naomi R. Wray, Adam Wright, Susanne A. Bengesser, Eva Reininghaus, Claudio E. M. Banzato, Clarissa Dantas, Martin Alda, Cristiana Cruceanu, Julie Garnham, Paul Grof, Glenda MacQueen, Guy Rouleau, Claire Slaney, Gustavo Turecki, L. Trevor Young, Carlos A. L{\'{o } }pez Jaramillo, Tom{\'{a } }s Nov{\'{a } }k, Pavla Stopkova, Clara Brichant-Petitjean, Mazda Adli, S{\'{e } }bastien Gard, Bruno Etain, St{\'{e } }phane Jamain, Jean-Pierre Kahn, Marion Leboyer, Mazda Adli, Michael Bauer, Sven Cichon, Franziska Degenhardt, Peter Falkai, Oliver Gruber, Urs Heilbronner, Per Hoffmann, Sarah Kittel-Schneider, Markus Nöthen, Andrea Pfennig, Daniela Reich-Erkelenz, Andreas Reif, Marcella Rietschel, Thomas G. Schulze, Florian Seemüller, Thomas Stamm, Raffaella Ardau, Caterina Chillotti, Maria Del Zompo, Mario Maj, Mirko Manchia, Palmiero Monteleone, Giovanni Severino, Alessio Squassina, Alfonso Tortorella, Kazufumi Akiyama, Kazufumi Akiyama, Ryota Hashimoto, Tadafumi Kato, Ichiro Kusumi, Takuya Masui Takuya Masui, Norio Ozaki, Piotr Czerski, Joanna Hauser, Sebastian Kliwicki, Janusz K. Rybakowski, Maria Grigoroiu-Serbanescu, Alex, ru Obregia, B{\'{a } }rbara Arias, Antonio Benabarre, Francesc Colom, Esther Jim{\'{e } }nez, Marina Mitjans, Eduard Vieta, Lena Backlund, Lena Backlund, Louise Fris{\'{e } }n, Catharina Lavebratt, Lina Martinsson, Urban Ösby, Martin Schalling, Jean-Michel Aubry, Sven Cichon, Alex, re Dayer, Per Hoffmann, Audrey Nallet, Hsi-Chung Chen, David Cousins, Nirmala Akula, Joanna M. Biernacka, Joanna M. Biernacka, Elise T. Bui, J. Ray DePaulo, Sevilla D. Detera-Wadleigh, Mark A. Frye, Fern, o S. Goes, Rebecca Hoban, Liping Hou, Layla Kassem, John R. Kelsoe, John R. Kelsoe, Gonzalo Laje, Gonzalo Laje, Susan G. Leckb, Michael J. McCarthy, Francis J. McMahon, Roy H. Perlis, James B. Potash, Thomas G. Schulze, Barbara Schweizer, Lisa R. Seymour, Jordan W. Smoller, Jo Steele, Sarah Tighe, Peter P. Z, i, Eva Reininghaus, Claudio E. M. Banzato, Clarissa Dantas, Martin Alda, Cristiana Cruceanu, Julie Garnham, Paul Grof, Glenda MacQueen, Guy Rouleau, Claire Slaney, Gustavo Turecki, L. Trevor Young, Carlos A. L{\'{o } }pez Jaramillo, Tom{\'{a } }s Nov{\'{a } }k, Pavla Stopkova, Clara Brichant-Petitjean, Bruno Etain, Mazda Adli, S{\'{e } }bastien Gard, St{\'{e } }phane Jamain, Jean-Pierre Kahn, Marion Leboyer, Mazda Adli, Michael Bauer, Sven Cichon, Franziska Degenhardt, Peter Falkai, Oliver Gruber, Urs Heilbronner, Per Hoffmann, Sarah Kittel-Schneider, Markus Nöthen, Andrea Pfennig, Daniela Reich-Erkelenz, Andreas Reif, Marcella Rietschel, Thomas G. Schulze, Florian Seemüller, Thomas Stamm, Raffaella Ardau, Caterina Chillotti, Maria Del Zompo, Maria Del Zompo, Mario Maj, Mirko Manchia, Palmiero Monteleone, Giovanni Severino, Alessio Squassina, Alfonso Tortorella, Kazufumi Akiyama, Ryota Hashimoto, Ichiro Kusumi, Takuya Masui, Norio Ozaki, Piotr Czerski, Joanna Hauser, Sebastian Kliwicki, Janusz K. Rybakowski, Maria Grigoroiu-Serbanescu, Alex, ru Obregia, B{\'{a } }rbara Arias, Antonio Benabarre, Francesc Colom, Esther Jim{\'{e } }nez, Marina Mitjans, Eduard Vieta, Lena Backlund, Louise Fris{\'{e } }n, Catharina Lavebratt, Lina Martinsson, Urban Ösby, Martin Schalling, Jean-Michel Aubry, Sven Cichon, Alex, re Dayer, Per Hoffmann, Audrey Nallet, Hsi-Chung Chen, David Cousins, Nirmala Akula, Joanna M. Biernacka, Elise T. Bui, J. Ray DePaulo, Sevilla D. Detera-Wadleigh, Mark A. Frye, Fern, o S. Goes, Rebecca Hoban, Liping Hou, Layla Kassem, John R. Kelsoe, Gonzalo Laje, Susan G. Leckb, Michael J. McCarthy, Francis J. McMahon, Roy H. Perlis, James B. Potash, Thomas G. Schulze, Barbara Schweizer, Lisa R. Seymour, Jordan W. Smoller, Jo Steele, Sarah Tighe, Peter P. Z, i, Peter Falkai, Udo Dannlowski, Tilo Kircher, Thomas G. Schulze, Sergi Papiol

    European Archives of Psychiatry and Clinical Neuroscience     2022.2

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    <jats:title>Abstract</jats:title><jats:p>Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (<jats:italic>N </jats:italic>= 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.</jats:p>

    DOI: 10.1007/s00406-021-01366-5

  77. Associations Among Maternal Metabolic Conditions, Cord Serum Leptin Levels, and Autistic Symptoms in Children

    Toshiki Iwabuchi, Nagahide Takahashi, Tomoko Nishimura, Md Shafiur Rahman, Taeko Harada, Akemi Okumura, Hitoshi Kuwabara, Shu Takagai, Yoko Nomura, Hideo Matsuzaki, Norio Ozaki, Kenji J. Tsuchiya

    Frontiers in Psychiatry   Vol. 12   page: 816196   2022.2

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    Introduction

    Accumulating evidence has shown that maternal metabolic conditions, such as pre-pregnancy overweight, diabetes mellitus, and hypertensive disorders of pregnancy (HDP) are potential risk factors of autism spectrum disorder (ASD). However, it remains unclear how these maternal conditions lead to neurodevelopmental outcomes in the offspring, including autistic symptoms. Leptin, an adipokine that has pro-inflammatory effects and affects fetal neurodevelopment, is a candidate mediator of the association between maternal metabolic factors and an increased risk of ASD. However, whether prenatal exposure to leptin mediates the association between maternal metabolic conditions and autistic symptoms in children has not been investigated yet.

    Methods

    This study investigated the associations between mothers' metabolic conditions (pre-pregnancy overweight, diabetes mellitus during or before pregnancy, and HDP), leptin concentrations in umbilical cord serum, and autistic symptoms among 762 children from an ongoing cohort study, using generalized structural equation modeling. We used the Social Responsive Scale, Second Edition (SRS-2) at 8–9 years old to calculate total T-scores. Additionally, we used the T-scores for two subdomains: Social Communication and Interaction (SCI) and Restricted Interests and Repetitive Behavior (RRB).

    Results

    Umbilical cord leptin levels were associated with pre-pregnancy overweight [coefficient = 1.297, 95% confidence interval (CI) 1.081–1.556, p = 0.005] and diabetes mellitus (coefficient = 1.574, 95% CI 1.206–2.055, p = 0.001). Furthermore, leptin levels were significantly associated with SRS-2 total T-scores (coefficient = 1.002, 95% CI 1.000–1.004, p = 0.023), SCI scores (coefficient = 1.002, 95% CI 1.000–1.004, p = 0.020), and RRB scores (coefficient = 1.001, 95% CI 1.000–1.003, p = 0.044) in children. Associations between maternal metabolic factors and autistic symptoms were not significant.

    Discussion

    The present study uncovered an association between cord leptin levels and autistic symptoms in children, while maternal metabolic conditions did not have an evident direct influence on the outcome. These results imply that prenatal pro-inflammatory environments affected by maternal metabolic conditions may contribute to the development of autistic symptoms in children. The findings warrant further investigation into the role of leptin in the development of autistic symptoms.

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  78. Magnetic resonance–guided focused ultrasound thalamotomy restored distinctive resting-state networks in patients with essential tremor International journal

    Sachiko Kato, Satoshi Maesawa, Epifanio Bagarinao, Daisuke Nakatsubo, Takahiko Tsugawa, Satomi Mizuno, Kazuya Kawabata, Takashi Tsuboi, Masashi Suzuki, Masashi Shibata, Sou Takai, Tomotaka Ishizaki, Jun Torii, Manabu Mutoh, Ryuta Saito, Toshihiko Wakabayashi, Masahisa Katsuno, Norio Ozaki, Hirohisa Watanabe, Gen Sobue

    Journal of Neurosurgery   Vol. 138 ( 2 ) page: 306 - 317   2022.2

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    OBJECTIVE

    Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy ameliorates symptoms in patients with essential tremor (ET). How this treatment affects canonical brain networks has not been elucidated. The purpose of this study was to clarify changes of brain networks after MRgFUS thalamotomy in ET patients by analyzing resting-state networks (RSNs).

    METHODS

    Fifteen patients with ET were included in this study. Left MRgFUS thalamotomy was performed in all cases, and MR images, including resting-state functional MRI (rsfMRI), were taken before and after surgery. MR images of 15 age- and sex-matched healthy controls (HCs) were also used for analysis. Using rsfMRI data, canonical RSNs were extracted by performing dual regression analysis, and the functional connectivity (FC) within respective networks was compared among pre-MRgFUS patients, post-MRgFUS patients, and HCs. The severity of tremor was evaluated using the Clinical Rating Scale for Tremor (CRST) score pre- and postoperatively, and its correlation with RSNs was examined.

    RESULTS

    Preoperatively, ET patients showed a significant decrease in FC in the sensorimotor network (SMN), primary visual network (VN), and visuospatial network (VSN) compared with HCs. The decrease in FC in the SMN correlated with the severity of tremor. After MRgFUS thalamotomy, ET patients still exhibited a significant decrease in FC in a small area of the SMN, but they exhibited an increase in the cerebellar network (CN). In comparison between pre- and post-MRgFUS patients, the FC in the SMN and the VSN significantly increased after treatment. Quantitative evaluation of the FCs in these three groups showed that the SMN and VSN increased postoperatively and demonstrated a trend toward those of HCs.

    CONCLUSIONS

    The SMN and CN, which are considered to be associated with the cerebello-thalamo-cortical loop, exhibited increased connectivity after MRgFUS thalamotomy. In addition, the FC of the visual network, which declined in ET patients compared with HCs, tended to normalize postoperatively. This could be related to the hypothesis that visual feedback is involved in tremor severity in ET patients. Overall, the analysis of the RSNs by rsfMRI reflected the pathophysiology with the intervention of MRgFUS thalamotomy in ET patients and demonstrated a possibility of a biomarker for successful treatment.

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    Other Link: https://thejns.org/downloadpdf/journals/j-neurosurg/aop/article-10.3171-2022.5.JNS22411/article-10.3171-2022.5.JNS22411.xml

  79. Perceived Social Support Partially Mediates the Impact of Temperament and Character on Postpartum Depression

    Yukako Nakamura, Nagahide Takahashi, Aya Yamauchi, Mako Morikawa, Takashi Okada, Norio Ozaki

    Frontiers in Psychiatry   Vol. 12   page: 816342   2022.1

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    <sec><title>Introduction</title>Temperament and character of pregnant women, especially harm avoidance (HA) and self-directedness (SD) have been identified as risk factors for postpartum depression, in addition to poor social support. However, the relationship between these personality traits and social support for depressive symptoms after delivery has not been examined.

    </sec><sec><title>Methods</title>Data were extracted from a prospective cohort survey on pregnant women conducted in Nagoya, Japan that included the Temperament and Character Inventory (TCI), the Social Support Questionnaire (J-SSQ), and the Edinburgh Postnatal Depression Scale (EPDS) at approximately week 25 and 1 month postpartum. A mediation analysis using structural equation modeling (SEM) was used to test if social support in pregnancy is a mediator between personality traits and postpartum depressive symptoms.

    </sec><sec><title>Results</title>Thousand five hundred and fifty-nine women were included in the analysis. Both harm avoidance and SD were significantly associated with depressive symptoms (total effect: β [SE], 0.298 [0.041], <italic>P</italic> &amp;lt; 0.001 for harm avoidance; total effect: β [SE], −0.265 [0.067], <italic>P</italic> &amp;lt; 0.001 for SD). Mediation analysis showed that the effect of harm avoidance on depressive symptoms was partially mediated by low social support (direct effect: β [SE], 0.193 [0.004], <italic>P</italic> &amp;lt; 0.001; indirect effect: β [SE], 0.082 [0.034], <italic>P</italic> = 0.015). Self-directedness on depressive symptoms was not found to be mediated by low social support.

    </sec><sec><title>Conclusion</title>Results indicate that poor social support worsens depressive symptoms in women with high HA during pregnancy. Limitations include a possible selection bias due to the limited target facilities; most variables being evaluated based on self-report questionnaires, and different number of samples available for analysis between harm avoidance and SD.

    </sec>

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  80. Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks

    Jingzhu Liao, Geyao Dong, Bolati Wulaer, Masahito Sawahata, Hiroyuki Mizoguchi, Daisuke Mori, Norio Ozaki, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada

    Behavioural Brain Research   Vol. 416   page: 113569 - 113569   2022.1

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    DOI: 10.1016/j.bbr.2021.113569

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  81. Autism spectrum disorder comorbid with obsessive compulsive disorder and eating disorder in a woman with NBEA deletion.

    Kato H, Kushima I, Yoshimi A, Ishizuka K, Kimura H, Aleksic B, Takahashi N, Okada T, Ozaki N

    Psychiatry and clinical neurosciences   Vol. 76 ( 1 ) page: 36 - 38   2022.1

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    DOI: 10.1111/pcn.13309

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  82. Trends in big data analyses by multicenter collaborative translational research in psychiatry. Reviewed International journal

    Toshiaki Onitsuka, Yoji Hirano, Kiyotaka Nemoto, Naoki Hashimoto, Itaru Kushima, Daisuke Koshiyama, Michihiko Koeda, Tsutomu Takahashi, Yoshihiro Noda, Junya Matsumoto, Kenichiro Miura, Takanobu Nakazawa, Takatoshi Hikida, Kiyoto Kasai, Norio Ozaki, Ryota Hashimoto

    Psychiatry and clinical neurosciences   Vol. 76 ( 1 ) page: 1 - 14   2022.1

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    The underlying pathologies of psychiatric disorders, which cause substantial personal and social losses, remain unknown, and their elucidation is an urgent issue. To clarify the core pathological mechanisms underlying psychiatric disorders, in addition to laboratory-based research that incorporates the latest findings, it is necessary to conduct large-sample-size research and verify reproducibility. For this purpose, it is critical to conduct multicenter collaborative research across various fields, such as psychiatry, neuroscience, molecular biology, genomics, neuroimaging, cognitive science, neurophysiology, psychology and pharmacology. Moreover, collaborative research plays an important role in the development of young researchers. In this respect, the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium and Cognitive Genetics Collaborative Research Organization (COCORO) have played important roles. In this review, we first overview the importance of multicenter collaborative research and our target psychiatric disorders. Then, we introduce research findings on the pathophysiology of psychiatric disorders from neurocognitive, neurophysiological, neuroimaging, genetic, and basic neuroscience perspectives, focusing mainly on the findings obtained by COCORO. It is our hope that multicenter collaborative research will contribute to the elucidation of the pathological basis of psychiatric disorders. This article is protected by copyright. All rights reserved.

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  83. Clinical guide for women with mental health problems during the perinatal period International journal

    Koichiro Shimoya, Tomomi Kotani, Shoji Satoh, Shunji Suzuki, Haruo Kashima, Kazuyoshi Ogasawara, Norio Ozaki, Eiji Suzuki, Yoshiyuki Tachibana, Toshihito Suzuki

    Journal of Obstetrics and Gynaecology Research   Vol. 48 ( 1 ) page: 20 - 33   2022.1

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    Pregnancy and childbirth have various effects on the physical as well as mental aspects of women. Therefore, appropriate considerations must be given to the mental health of pregnant women. The Guideline Review Committee of the Japanese Society of Psychiatry and Neurology launched a liaison meeting for the Japanese Society of Psychiatry and Neurology and the Japan Society of Obstetrics and Gynecology, with a view to creating a "Clinical guide for women with mental health problems during the perinatal period" by cooperation of these two fields. After repeated discussions with input from both academic societies, they jointly formulated the "Clinical guide for women with mental health problems during the perinatal period: Overview" in May 2020, and reported its "Detailed Contents" in April 2021. We hope that this guide, which is the English overview of the detailed guide, will contribute to the mental health of pregnant women, facilitating healthy pregnancies and childbirth.

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jog.15068

  84. A Study of Factors Causing Sleep State Misperception in Patients with Depression. International journal

    Keita Kawai, Kunihiro Iwamoto, Seiko Miyata, Ippei Okada, Motoo Ando, Hiroshige Fujishiro, Akiko Noda, Norio Ozaki

    Nature and science of sleep   Vol. 14   page: 1273 - 1283   2022

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    Purpose: Sleep state misperception, which is the discrepancy between subjective and objective sleep, is often observed in patients with depression. This phenomenon may delay the remission of depression. Previous studies have focused on the total sleep time (TST) misperception, with many of these studies using actigraphy. Thus, our study investigated depressed patients with the exploratory aim of clarifying factors associated with the sleep state misperception including the wake after sleep onset (WASO) misperception, with their objective sleep additionally evaluated by polysomnography (PSG). Patients and Methods: We conducted a cross-sectional study. Before undergoing overnight PSG monitoring, 40 patients with depression completed questionnaires that included the Beck Depression Inventory (BDI), Epworth sleepiness scale, Temperament and Character Inventory, and the Pittsburgh sleep quality index. Patients were also asked to estimate their subjective sleep duration after they woke up in the morning. Based on this data, we calculated the misperception using the following formula: subjective sleep duration minus objective sleep duration. We compared each factor between negative and positive misperception groups and the multiple regression analysis was performed for TST and WASO misperception, respectively. Results: Although sleep architectures, age, severity of depression and obstructive sleep apnea (OSA) exhibited differences in underestimating or overestimating the WASO, only sex differences were associated with underestimating or overestimating their total sleep time (TST). Moreover, BDI, the severity of OSA, sleep architectures (N1% and N2%), and benzodiazepine (BZD) use were significantly correlated with WASO misperception, whereas only OSA severity was significantly correlated with TST misperception. A subsequent multiple regression analysis demonstrated the BDI was independently correlated with the WASO misperception (β=0.341, p=0.049). Conclusion: In clinical practice, interventions especially for OSA, and the reduction of depressive symptoms are an important method for improving patient sleep perception. Moreover, current results suggest that BZD prescriptions should be avoided as well.

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  85. Reserve and maintenance in the aging brain: A longitudinal study of healthy older adults. International journal

    Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Kazuya Kawabata, Kazuhiro Hara, Reiko Ohdake, Aya Ogura, Daisuke Mori, Noritaka Yoneyama, Kazunori Imai, Takamasa Yokoi, Toshiyasu Kato, Shuji Koyama, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

    eNeuro   Vol. 9 ( 1 )   2022

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    The aging brain undergoes structural changes even in very healthy individuals. Quantifying these changes could help disentangle pathological changes from those associated with the normal human aging process. Using longitudinal MRI data from 227 carefully selected healthy human cohort with age ranging from 50 to 80 years old at baseline scan, we quantified age-related volumetric changes in the brain of healthy human older adults. Longitudinally, the rates of tissue loss in total gray matter (GM) and white matter were 2,497.5 mm3 per year and 2,579.8 mm3 per year, respectively. Across the whole brain, the rates of GM decline varied with regions in the frontal and parietal lobes having faster rates of decline, whereas some regions in the occipital and temporal lobes appeared relatively preserved. In contrast, cross sectional changes were mainly observed in the temporal-occipital regions. Similar longitudinal atrophic changes were also observed in subcortical regions including thalamus, hippocampus, putamen, and caudate, whereas the pallidum showed an increasing volume with age. Overall, regions maturing late in development (frontal, parietal) are more vulnerable to longitudinal decline, whereas those that fully mature in the early stage (temporal, occipital) are mainly affected by cross sectional changes in healthy older cohort. This may suggest that, for a successful healthy aging, the former needs to be maximally developed at an earlier age to compensate for the longitudinal decline later in life and the latter to remain relatively preserved even in old age, consistent with both concepts of reserve and brain maintenance.Significance StatementAging is associated with gray matter (GM) decline, yet some individuals tend to remain cognitively healthy even in advanced age. What differentiates the brains of "healthy agers" from those individuals who are prone to faster cognitive decline still remains unclear. Using longitudinal MRI data from a carefully selected cohort, we examined the brain aging characteristics of healthy agers. Our findings showed that, even in this population, frontal-parietal regions have faster longitudinal rate of GM decline, whereas some temporal-occipital regions appeared relatively preserved. These findings may suggest that, for a successful healthy aging, frontal-parietal regions need to be maximally developed to compensate for the longitudinal decline later in life and the temporal-occipital regions to remain relatively preserved even in old age.

    DOI: 10.1523/ENEURO.0455-21.2022

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  86. Involvement of cerebellar and subcortical connector hubs in schizophrenia

    Yamamoto Maeri, Bagarinao Epifanio, Shimamoto Masanori, Iidaka Tetsuya, Ozaki Norio

    NEUROIMAGE-CLINICAL   Vol. 35   page: 103140   2022

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  87. Exonic deletions in IMMP2L in schizophrenia with enhanced glycation stress subtype International journal

    Akane Yoshikawa, Itaru Kushima, Mitsuhiro Miyashita, Kazuhiro Suzuki, Kyoka Iino, Kazuya Toriumi, Yasue Horiuchi, Hideya Kawaji, Norio Ozaki, Masanari Itokawa, Makoto Arai

    PLOS ONE   Vol. 17 ( 7 ) page: e0270506 - e0270506   2022

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    We previously identified a subtype of schizophrenia (SCZ) characterized by increased plasma pentosidine, a marker of glycation and oxidative stress (PEN-SCZ). However, the genetic factors associated with PEN-SCZ have not been fully clarified. We performed a genome-wide copy number variation (CNV) analysis to identify CNVs associated with PEN-SCZ to provide an insight into the novel therapeutic targets for PEN-SCZ. Plasma pentosidine was measured by high-performance liquid chromatography in 185 patients with SCZ harboring rare CNVs detected by array comparative genomic hybridization. In three patients with PEN-SCZ showing additional autistic features, we detected a novel deletion at 7q31.1 within exons 2 and 3 of IMMP2L, which encodes the inner mitochondrial membrane peptidase subunit 2. The deletion was neither observed in non-PEN-SCZ nor in public database of control subjects. IMMP2L is one of the SCZ risk loci genes identified in a previous SCZ genome-wide association study, and its trans-populational association was recently described. Interestingly, deletions in IMMP2L have been previously linked with autism spectrum disorder. Disrupted IMMP2L function has been shown to cause glycation/oxidative stress in neuronal cells in an age-dependent manner. To our knowledge, this is the first genome-wide CNV study to suggest the involvement of IMMP2L exons 2 and 3 in the etiology of PEN-SCZ. The combination of genomic information with plasma pentosidine levels may contribute to the classification of biological SCZ subtypes that show additional autistic features. Modifying IMMP2L functions may be useful for treating PEN-SCZ if the underlying biological mechanism can be clarified in further studies.

    DOI: 10.1371/journal.pone.0270506

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  88. Exome sequencing of Japanese schizophrenia multiplex families supports the involvement of calcium ion channels International journal

    Miho Toyama, Yuto Takasaki, Aleksic Branko, Hiroki Kimura, Hidekazu Kato, Yoshihiro Nawa, Itaru Kushima, Kanako Ishizuka, Teppei Shimamura, Tomoo Ogi, Norio Ozaki

    PLOS ONE   Vol. 17 ( 5 ) page: e0268321 - e0268321   2022

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    Background

    Most sequencing studies of schizophrenia (SCZ) have focused on de novo genetic variants due to interpretability. However, investigating shared rare variants among patients in the same multiplex family is also important. Relatively large-scale analyses of SCZ multiplex families have been done in Caucasian populations, but whether detected variants are also pathogenic in the Japanese population is unclear because of ethnic differences in rare variants.

    Materials and methods

    We performed whole-exome sequencing (WES) of 14 Japanese SCZ multiplex families. After quality control and filtering, we identified rare variants shared among affected persons within the same family. A gene ontology (GO) analysis was performed to identify gene categories possibly affected by these candidate variants.

    Results

    We found 530 variants in 486 genes as potential candidate variants from the 14 SCZ multiplex families examined. The GO analysis demonstrated significant enrichment in calcium channel activity.

    Conclusion

    This study provides supporting evidence that calcium ion channel activity is involved in SCZ. WES of multiplex families is a potential means of identifying disease-associated rare variants for SCZ.

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  89. Association between effect of duloxetine on chronic orofacial pain and expression of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia

    Mariko Nakamura, Yoshimi Akira, Mouri Akihiro, Tokura Tatsuya, Kimura Hiroyuki, Kishi Shinichi, Miyauchi Tomoya, Iwamoto Kunihiro, Ito Mikiko, Sato Aiji, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro

    Proceedings for Annual Meeting of The Japanese Pharmacological Society   Vol. 95   page: 1-P-081   2022

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    <b>Introduction:</b> Burning mouth syndrome and atypical odontalgia (BMS/AO) are chronic orofacial pain conditions in the absence of any identifiable odontogenic pathology. The pain is treatment-resistant and frequently causes depressive symptoms. Duloxetine (DLX), a serotonin-noradrenaline reuptake inhibitor, is not only used as therapy for depression, but also for chronic orofacial pain. Since their mechanisms in detail remains unknown, in this study, we focused on serotonin transporter (SERT), one of DLX action site, and investigated association between expression of SERT and effect of DLX on pain in BMS/AO.

    <b>Methods:</b> The patients with BMS/AO, were assessed for severity of pain using the visual analog scale (VAS) and for signs of depression using the Hamilton Depression Rating Scale (HDRS). In their platelets before (baseline) and 12 weeks after DLX-treatment,<b> </b>the<b> </b>expression of total and ubiquitinated SERT proteins was confirmed by Western blot. This study was approved by the Ethics Review Committees of Nagoya, Aichi Gakuin, and Meijo Universities.

    <b>Results:</b> The expression of total and ubiquitinated SERT protein at baseline in all patients were higher and lower, respectively, compared to those in controls. After the DLX-treatment, there was no difference in the total SERT protein levels between the patients and controls. The mean of VAS and HDRS scores or the expression of total SERT protein were significantly decreased after the treatment, compared to those at baseline. 

    <b>Conclusions:</b> These results indicate that DLX relieves chronic orofacial pain in patients with BMS/AO, and such effect may be mediated via SERT downregulation.

    DOI: 10.1254/jpssuppl.95.0_1-p-081

  90. Patient characteristics affecting accurate detection of sleep apnea using a bed sheet-type portable monitor.

    Miyata S, Otake H, Ando M, Okuda M, Fujishiro H, Iwamoto K, Noda A, Sone M, Ozaki N

    Sleep & breathing = Schlaf & Atmung     2019.11

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    DOI: 10.1007/s11325-019-01963-8

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  91. Cutting edge morphological studies of postmortem brains of patients with schizophrenia and potential applications of X-ray nanotomography (nano-CT).

    Itokawa M, Oshima K, Arai M, Torii Y, Kushima I, Iritani S, Ozaki N, Saiga R, Mizutani R

    Psychiatry and clinical neurosciences     2019.11

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    DOI: 10.1111/pcn.12957

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  92. Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome

    Baba Masayuki, Yokoyama Kazumasa, Seiriki Kaoru, Naka Yuichiro, Matsumura Kensuke, Kondo Momoka, Yamamoto Kana, Hayashida Misuzu, Kasai Atsushi, Ago Yukio, Nagayasu Kazuki, Hayata-Takano Atsuko, Takahashi Akinori, Yamaguchi Shun, Mori Daisuke, Ozaki Norio, Yamamoto Tadashi, Takuma Kazuhiro, Hashimoto Ryota, Hashimoto Hitoshi, Nakazawa Takanobu

    NEUROPSYCHOPHARMACOLOGY   Vol. 44 ( 12 ) page: 2125-2135   2019.11

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    DOI: 10.1038/s41386-019-0441-5

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  93. POLYGENIC RISK SCORES IN SCHIZOPHRENIA WITH CLINICALLY SIGNIFICANT COPY NUMBER VARIANTS

    Taniguchi Satoru, Ninomiya Kohei, Kushima Itaru, Okochi Tomo, Saito Takeo, Shimasaki Ayu, Sakusabe Takaya, Momozawa Yukihide, Kubo Michiaki, Kamatani Yoichiro, Ozaki Norio, Ikeda Masashi, Iwata Nakao

    EUROPEAN NEUROPSYCHOPHARMACOLOGY   Vol. 29   page: S212-S212   2019.10

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    DOI: 10.1016/j.euroneuro.2019.08.184

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  94. Clinicopathological differences between the motor onset and psychiatric onset of Huntington's disease, focusing on the nucleus accumbens

    Hirano Mitsuaki, Iritani Shuji, Fujishiro Hiroshige, Torii Youta, Habuchi Chikako, Sekiguchi Hirotaka, Yoshida Mari, Ozaki Norio

    NEUROPATHOLOGY   Vol. 39 ( 5 ) page: 331-341   2019.10

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    DOI: 10.1111/neup.12578

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  95. A battery of self-screening instruments and self-reported body frame could not detect eating disorders among college students.

    Hayakawa N, Tanaka S, Hirata N, Ogino S, Ozaki N

    BMC research notes   Vol. 12 ( 1 ) page: 613   2019.9

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    DOI: 10.1186/s13104-019-4672-7

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  96. In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of PCDH15 and RELN

    Ishii, T. Ishikawa, M. Fujimori, K. Maeda, T. Kushima, I. Arioka, Y. Mori, D. Nakatake, Y. Yamagata, B. Nio, S. Kato, T. A. Yang, N. Wernig, M. Kanba, S. Mimura, M. Ozaki, N. Okano, H.

    eNeuro     2019.9

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    DOI: doi.org/10.1523/ENEURO.0403-18.2019

  97. Reorganization of brain networks and its association with general cognitive performance over the adult lifespan

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Taoka Toshiaki, Koyama Shuji, Tanabe Hiroki C., Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Ozaki Norio, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Sobue Gen

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 11352   2019.8

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    DOI: 10.1038/s41598-019-47922-x

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  98. Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms

    Teshigawara Tomoaki, Mouri Akihiro, Kubo Hisako, Nakamura Yukako, Shiino Tomoko, Okada Takashi, Morikawa Mako, Nabeshima Toshitaka, Ozaki Norio, Yamamoto Yasuko, Saito Kuniaki

    JOURNAL OF AFFECTIVE DISORDERS   Vol. 255   page: 168-176   2019.8

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    DOI: 10.1016/j.jad.2019.05.028

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  99. Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration

    Uchida Mizuki, Hida Hirotake, Mori Kentaro, Yoshimi Akira, Kitagaki Shinji, Yamada Kiyofumi, Hiraoka Yuichi, Aida Tomomi, Tanaka Kohichi, Ozaki Norio, Noda Yukihiro

    EUROPEAN NEUROPSYCHOPHARMACOLOGY   Vol. 29 ( 8 ) page: 914-924   2019.8

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    DOI: 10.1016/j.euroneuro.2019.06.005

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  100. Clinical profiles of late-onset psychiatric patients exhibiting incidental REM sleep without atonia

    Fujishiro Hiroshige, Okuda Masato, Iwamoto Kunihiro, Miyata Seiko, Torii Youta, Iritani Shuji, Ozaki Norio

    JOURNAL OF NEURAL TRANSMISSION   Vol. 126 ( 8 ) page: 1095-1104   2019.8

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    DOI: 10.1007/s00702-019-02035-7

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  101. Relation Between Perinatal Depressive Symptoms, Harm Avoidance, and a History of Major Depressive Disorder: A Cohort Study of Pregnant Women in Japan

    Kubota Chika, Inada Toshiya, Shiino Tomoko, Ando Masahiko, Aleksic Branko, Yamauchi Aya, Sato Maya, Ohara Masako, Murase Satomi, Morikawa Mako, Nakamura Yukako, Okada Takashi, Goto Setsuko, Kanai Atsuko, Ozaki Norio

    FRONTIERS IN PSYCHIATRY   Vol. 10   page: 515   2019.7

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    DOI: 10.3389/fpsyt.2019.00515

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  102. Effects of sleep-disordered breathing and hypertension on cognitive function in elderly adults

    Kato Kazuko, Noda Akiko, Yasuma Fumihiko, Matsubara Yuka, Miyata Seiko, Iwamoto Kunihiro, Miyazaki Soichiro, Ozaki Norio

    CLINICAL AND EXPERIMENTAL HYPERTENSION     page: 1-7   2019.7

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    DOI: 10.1080/10641963.2019.1632338

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  103. Quantitative facial expression analysis revealed the efficacy and time course of oxytocin in autism

    Owada Keiho, Okada Takashi, Munesue Toshio, Kuroda Miho, Fujioka Toru, Uno Yota, Matsumoto Kaori, Kuwabara Hitoshi, Mori Daisuke, Okamoto Yuko, Yoshimura Yuko, Kawakubo Yuki, Arioka Yuko, Kojima Masaki, Yuhi Teruko, Yassin Walid, Kushima Itaru, Benner Seico, Ogawa Nanayo, Kawano Naoko, Eriguchi Yosuke, Uemura Yukari, Yamamoto Maeri, Kano Yukiko, Kasai Kiyoto, Higashida Haruhiro, Ozaki Norio, Kosaka Hirotaka, Yamasue Hidenori

    BRAIN   Vol. 142 ( 7 ) page: 2127-2136   2019.7

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    DOI: 10.1093/brain/awz126

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  104. Effect of antidepressant treatment on plasma levels of neuroinflammation-associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region

    Miyauchi Tomoya, Tokura Tatsuya, Kimura Hiroyuki, Ito Mikiko, Umemura Eri, Sato (Bokuj) Aiji, Nagashima Wataru, Tonoike Takashi, Yamamoto Yasuko, Saito Kuniaki, Kurita Kenichi, Ozaki Norio

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 34 ( 4 ) page: e2698   2019.7

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    DOI: 10.1002/hup.2698

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  105. Methylation analysis for postpartum depression: a case control study

    Nakamura Yukako, Nakatochi Masahiro, Kunimoto Shohko, Okada Takashi, Aleksic Branko, Toyama Miho, Shiino Tomoko, Morikawa Mako, Yamauchi Aya, Yoshimi Akira, Furukawa-Hibi Yoko, Nagai Taku, Ohara Masako, Kubota Chika, Yamada Kiyofumi, Ando Masahiko, Ozaki Norio

    BMC PSYCHIATRY   Vol. 19 ( 1 ) page: 190   2019.6

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    DOI: 10.1186/s12888-019-2172-x

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  106. Oral medicine psychiatric liaison clinic: study of 1202 patients attending over an 18-year period

    Umemura E., Tokura T., Ito M., Kobayashi Y., Tachibana M., Miyauchi T., Tonoike T., Nagashima W., Kimura H., Arao M., Sato (Boku) A., Ozaki N., Kurita K.

    INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY   Vol. 48 ( 5 ) page: 644-650   2019.5

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    DOI: 10.1016/j.ijom.2018.12.005

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  107. Exploration of coping styles in male patients with head and neck cancer: a prospective cohort study

    Sato Naohiro, Kimura Hiroyuki, Adachi Yasunori, Nishio Naoki, Ando Masahiko, Tokura Tatsuya, Nagashima Wataru, Kishi Shinichi, Yamauchi Aya, Yoshida Keizo, Hiramatsu Mariko, Fujimoto Yasushi, Ozaki Norio

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 2 ) page: 249-258   2019.5

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    DOI: 10.18999/nagjms.81.2.249

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  108. Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients.

    Yoshimi A, Yamada S, Kunimoto S, Aleksic B, Hirakawa A, Ohashi M, Matsumoto Y, Hada K, Itoh N, Arioka Y, Kimura H, Kushima I, Nakamura Y, Shiino T, Mori D, Tanaka S, Hamada S, Noda Y, Nagai T, Yamada K, Ozaki N

    Translational psychiatry   Vol. 9 ( 1 ) page: 126   2019.4

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    DOI: 10.1038/s41398-019-0461-2

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  109. Blonanserin ameliorates social deficit through dopamine-D<sub>3</sub> receptor antagonism in mice administered phencyclidine as an animal model of schizophrenia.

    Takeuchi S, Hida H, Uchida M, Naruse R, Yoshimi A, Kitagaki S, Ozaki N, Noda Y

    Neurochemistry international   Vol. 128   page: 127-134   2019.4

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    DOI: 10.1016/j.neuint.2019.04.008

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  110. Acute administration of ketamine attenuates the impairment of social behaviors induced by social defeat stress exposure as juveniles via activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors

    Hasegawa Sho, Yoshimi Akira, Mouri Akihiro, Uchida Yoji, Hida Hirotake, Mishina Masayoshi, Yamada Kiyofumi, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro

    NEUROPHARMACOLOGY   Vol. 148   page: 107-116   2019.4

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    DOI: 10.1016/j.neuropharm.2018.12.020

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  111. Decline of Plasma Concentrations of Interleukin-18 in Severely Malnourished Patients with Anorexia Nervosa: Exploratory Analysis

    Tanaka Satoshi, Oya-Ito Tomoko, Murakami Yuki, Saito Kuniaki, Furuta Sho, Yu Yanjie, Imaeda Miho, Kunimoto Shohko, Ozaki Norio

    NUTRIENTS   Vol. 11 ( 3 )   2019.3

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    DOI: 10.3390/nu11030540

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  112. Hypochondriasis in the elderly and Lewy body disease.

    Fujishiro H, Kimura H, Nakamura T, Torii Y, Iritani S, Ozaki N

    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society     2019.2

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    DOI: 10.1111/psyg.12425

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  113. Three-dimensional alteration of neurites in schizophrenia

    Mizutani Ryuta, Saiga Rino, Takeuchi Akihisa, Uesugi Kentaro, Terada Yasuko, Suzuki Yoshio, De Andrade Vincent, De Carlo Francesco, Takekoshi Susumu, Inomoto Chie, Nakamura Naoya, Kushima Itaru, Iritani Shuji, Ozaki Norio, Ide Soichiro, Ikeda Kazutaka, Oshima Kenichi, Itokawa Masanari, Arai Makoto

    TRANSLATIONAL PSYCHIATRY   Vol. 9 ( 1 ) page: 85   2019.2

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    DOI: 10.1038/s41398-019-0427-4

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  114. Application of eye trackers for understanding mental disorders: Cases for schizophrenia and autism spectrum disorder.

    Shishido E, Ogawa S, Miyata S, Yamamoto M, Inada T, Ozaki N

    Neuropsychopharmacology reports     2019.2

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    DOI: 10.1002/npr2.12046

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  115. Protocol for the development and validation of a driving simulator for evaluating the influence of drugs on driving performance

    Iwata Mari, Iwamoto Kunihiro, Omura Tomohiro, Ando Masahiko, Ozaki Norio

    MEDICINE   Vol. 98 ( 8 ) page: e14613   2019.2

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    DOI: 10.1097/MD.0000000000014613

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  116. A Network of Networks Approach for Modeling Interconnected Brain Tissue-Specific Networks.

    Kawakubo H, Matsui Y, Kushima I, Ozaki N, Shimamura T

    Bioinformatics (Oxford, England)     2019.1

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    DOI: 10.1093/bioinformatics/btz032

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  117. Characterization of a schizophrenia patient with a rare RELN deletion by combining genomic and patient-derived cell analyses

    Arioka, Y Hirata, A Kushima, I Aleksic, B Mori, D Ozaki, N

    Schizophr Res     2019

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    DOI: 10.1016/j.schres.2019.10.038

  118. In Vitro Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of PCDH15 and RELN

    Ishii Takaya, Ishikawa Mitsuru, Fujimori Koki, Maeda Takuji, Kushima Itaru, Arioka Yuko, Mori Daisuke, Nakatake Yuhki, Yamagata Bun, Nio Shintaro, Kato Takahiro A., Yang Nan, Wernig Marius, Kanba Shigenobu, Mimura Masaru, Ozaki Norio, Okano Hideyuki

    ENEURO   Vol. 6 ( 5 )   2019

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    DOI: 10.1523/ENEURO.0403-18.2019

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  119. Stable factor structure of the Edinburgh Postnatal Depression Scale during the whole peripartum period: Results from a Japanese prospective cohort study

    Kubota Chika, Inada Toshiya, Nakamura Yukako, Shiino Tomoko, Ando Masahiko, Aleksic Branko, Yamauchi Aya, Morikawa Mako, Okada Takashi, Ohara Masako, Sato Maya, Murase Satomi, Goto Setsuko, Kanai Atsuko, Ozaki Norio

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 17659   2018.12

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    DOI: 10.1038/s41598-018-36101-z

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  120. Effects of hypnotics on prefrontal cortex activity during a verbal fluency task in healthy male subjects: A near-infrared spectroscopy study

    Tsuruta Yoshiyuki, Iwamoto Kunihiro, Banno Masahiro, Kawano Naoko, Kohmura Kunihiro, Miyata Seiko, Fujishiro Hiroshige, Noda Yukihiro, Noda Akiko, Iritani Shuji, Ozaki Norio

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 33 ( 6 ) page: e2678   2018.11

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    DOI: 10.1002/hup.2678

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  121. Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

    Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, Shimasaki A, Kawase K, Sakusabe T, Iwayama Y, Toyota T, Wakuda T, Kikuchi M, Kanahara N, Yamamori H, Yasuda Y, Watanabe Y, Hoya S, Aleksic B, Kushima I, Arai H, Takaki M, Hattori K, Kunugi H, Okahisa Y, Ohnuma T, Ozaki N, Someya T, Hashimoto R, Yoshikawa T, Kubo M, Iwata N

    Schizophrenia bulletin     2018.10

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    DOI: 10.1093/schbul/sby140

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  122. Evaluation method regarding the effect of psychotropic drugs on driving performance: A literature review.

    Iwata M, Iwamoto K, Kawano N, Kawaue T, Ozaki N

    Psychiatry and clinical neurosciences   Vol. 72 ( 10 ) page: 747-773   2018.10

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    DOI: 10.1111/pcn.12734

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  123. Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia.

    Ishizuka K, Kimura H, Kushima I, Inada T, Okahisa Y, Ikeda M, Iwata N, Mori D, Aleksic B, Ozaki N

    Psychiatric genetics   Vol. 28 ( 5 ) page: 90-93   2018.10

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    DOI: 10.1097/YPG.0000000000000204

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  124. Impact of perceived rearing and social support on bonding failure and depression among mothers: A longitudinal study of pregnant women.

    Ohara M, Nakatochi M, Okada T, Aleksic B, Nakamura Y, Shiino T, Yamauchi A, Kubota C, Morikawa M, Murase S, Goto S, Kanai A, Kato R, Ando M, Ozaki N

    Journal of psychiatric research   Vol. 105   page: 71-77   2018.10

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    DOI: 10.1016/j.jpsychires.2018.09.001

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  125. Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights.

    Kushima I, Aleksic B, Nakatochi M, Shimamura T, Okada T, Uno Y, Morikawa M, Ishizuka K, Shiino T, Kimura H, Arioka Y, Yoshimi A, Takasaki Y, Yu Y, Nakamura Y, Yamamoto M, Iidaka T, Iritani S, Inada T, Ogawa N, Shishido E, Torii Y, Kawano N, Omura Y, Yoshikawa T, Uchiyama T, Yamamoto T, Ikeda M, Hashimoto R, Yamamori H, Yasuda Y, Someya T, Watanabe Y, Egawa J, Nunokawa A, Itokawa M, Arai M, Miyashita M, Kobori A, Suzuki M, Takahashi T, Usami M, Kodaira M, Watanabe K, Sasaki T, Kuwabara H, Tochigi M, Nishimura F, Yamasue H, Eriguchi Y, Benner S, Kojima M, Yassin W, Munesue T, Yokoyama S, Kimura R, Funabiki Y, Kosaka H, Ishitobi M, Ohmori T, Numata S, Yoshikawa T, Toyota T, Yamakawa K, Suzuki T, Inoue Y, Nakaoka K, Goto YI, Inagaki M, Hashimoto N, Kusumi I, Son S, Murai T, Ikegame T, Okada N, Kasai K, Kunimoto S, Mori D, Iwata N, Ozaki N

    Cell reports   Vol. 24 ( 11 ) page: 2838-2856   2018.9

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    DOI: 10.1016/j.celrep.2018.08.022

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  126. The neuropathological investigation of the brain in a monkey model of autism spectrum disorder with ABCA13 deletion.

    Iritani S, Torii Y, Habuchi C, Sekiguchi H, Fujishiro H, Yoshida M, Go Y, Iriki A, Isoda M, Ozaki N

    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience   Vol. 71   page: 130-139   2018.9

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    DOI: 10.1016/j.ijdevneu.2018.09.002

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  127. Dysfunction of Serotonergic and Dopaminergic Neuronal Systems in the Antidepressant-Resistant Impairment of Social Behaviors Induced by Social Defeat Stress Exposure as Juveniles.

    Hasegawa S, Miyake Y, Yoshimi A, Mouri A, Hida H, Yamada K, Ozaki N, Nabeshima T, Noda Y

    The international journal of neuropsychopharmacology   Vol. 21 ( 9 ) page: 837-846   2018.9

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    DOI: 10.1093/ijnp/pyy038

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  128. Aberrant functional connectivity between the thalamus and visual cortex is related to attentional impairment in schizophrenia

    Yamamoto Maeri, Kushima Itaru, Suzuki Ryohei, Branko Aleksic, Kawano Naoko, Inada Toshiya, Iidaka Tetsuya, Ozaki Norio

    PSYCHIATRY RESEARCH-NEUROIMAGING   Vol. 278   page: 35-41   2018.8

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    DOI: 10.1016/j.pscychresns.2018.06.007

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  129. Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia

    Sobue Akira, Kushima Itaru, Nagai Taku, Shan Wei, Kohno Takao, Aleksic Branko, Aoyama Yuki, Mori Daisuke, Arioka Yuko, Kawano Naoko, Yamamoto Maeri, Hattori Mitsuharu, Nabeshima Toshitaka, Yamada Kiyofumi, Ozaki Norio

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 13046   2018.8

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    DOI: 10.1038/s41598-018-31390-w

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  130. Postpartum depression among women in Nagoya indirectly exposed to the Great East Japan Earthquake

    Kubota Chika, Okada Takashi, Morikawa Mako, Nakamura Yukako, Yamauchi Aya, Ando Masahiko, Shiino Tomoko, Ohara Masako, Murase Satomi, Goto Setsuko, Kanai Atsuko, Masuda Tomoko, Aleksic Branko, Ozaki Norio

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 11624   2018.8

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    DOI: 10.1038/s41598-018-30065-w

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  131. Three lines of induced pluripotent stem cells derived from a 15q11.2-q13.1 duplication syndrome patient

    Arioka Yuko, Kushima Itaru, Mori Daisuke, Ozaki Norio

    STEM CELL RESEARCH   Vol. 31   page: 240-243   2018.8

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    DOI: 10.1016/j.scr.2018.08.004

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  132. The neuropathological study of myelin oligodendrocyte glycoprotein in the temporal lobe of schizophrenia patients

    Marui Tomoyasu, Torii Youta, Iritani Shuji, Sekiguchi Hirotaka, Habuchi Chikako, Fujishiro Hiroshige, Oshima Kenichi, Niizato Kazuhiro, Hayashida Shotaro, Masaki Katsuhisa, Kira Junichi, Ozaki Norio

    ACTA NEUROPSYCHIATRICA   Vol. 30 ( 4 ) page: 232-240   2018.8

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    DOI: 10.1017/neu.2018.6

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  133. Single-cell trajectory analysis of human homogenous neurons carrying a rare RELN variant

    Arioka Yuko, Shishido Emiko, Kubo Hisako, Kushima Itaru, Yoshimi Akira, Kimura Hiroki, Ishizuka Kanako, Aleksic Branko, Maeda Takuji, Ishikawa Mitsuru, Kuzumaki Naoko, Okano Hideyuki, Mori Daisuke, Ozaki Norio

    TRANSLATIONAL PSYCHIATRY   Vol. 8 ( 1 ) page: 129   2018.7

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    DOI: 10.1038/s41398-018-0177-8

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  134. Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability.

    Kunisawa K, Shimizu T, Kushima I, Aleksic B, Mori D, Osanai Y, Kobayashi K, Taylor AM, Bhat MA, Hayashi A, Baba H, Ozaki N, Ikenaka K

    Journal of neurochemistry     2018.7

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    DOI: 10.1111/jnc.14553

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  135. Abnormalities of eye movement are associated with work hours in schizophrenia.

    Morita K, Miura K, Fujimoto M, Shishido E, Shiino T, Takahashi J, Yamamori H, Yasuda Y, Kudo N, Hirano Y, Koshiyama D, Okada N, Ikeda M, Onitsuka T, Ozaki N, Kasai K, Hashimoto R

    Schizophrenia research     2018.7

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    DOI: 10.1016/j.schres.2018.06.064

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  136. Re-evaluating classical body type theories: genetic correlation between psychiatric disorders and body mass index

    Ikeda Masashi, Tanaka Satoshi, Saito Takeo, Ozaki Norio, Kamatani Yoichiro, Iwata Nakao

    PSYCHOLOGICAL MEDICINE   Vol. 48 ( 10 ) page: 1745-1748   2018.7

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    DOI: 10.1017/S0033291718000685

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  137. Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion

    Arioka Yuko, Kushima Itaru, Kubo Hisako, Mori Daisuke, Ozaki Norio

    STEM CELL RESEARCH   Vol. 30   page: 81-84   2018.7

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    DOI: 10.1016/j.scr.2018.05.013

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  138. Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial

    Yamasue, H. Okada, T. Munesue, T. Kuroda, M. Fujioka, T. Uno, Y. Matsumoto, K. Kuwabara, H. Mori, D. Okamoto, Y. Yoshimura, Y. Kawakubo, Y. Arioka, Y. Kojima, M. Yuhi, T. Owada, K. Yassin, W. Kushima, I. Benner, S. Ogawa, N. Eriguchi, Y. Kawano, N. Uemura, Y. Yamamoto, M. Kano, Y. Kasai, K. Higashida, H. Ozaki, N. Kosaka, H.

    Mol Psychiatry     2018.6

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    DOI: doi.org/10.1038/s41380-018-0097-2

  139. Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial.

    Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H

    Molecular psychiatry     2018.6

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    DOI: 10.1038/s41380-018-0097-2

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  140. Validation and Factor Analysis of the Japanese Version of the Highs Scale in Perinatal Women

    Yamauchi Aya, Okada Takashi, Ando Masahiko, Morikawa Mako, Nakamura Yukako, Kubota Chika, Ohara Masako, Murase Satomi, Goto Setsuko, Kanai Atsuko, Ozaki Norio

    FRONTIERS IN PSYCHIATRY   Vol. 9   page: 269   2018.6

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    DOI: 10.3389/fpsyt.2018.00269

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  141. Early diagnosis of Lewy body disease in patients with late-onset psychiatric disorders using clinical history of rapid eye movement sleep behavior disorder and [I-123]-metaiodobenzylguanidine cardiac scintigraphy

    Fujishiro Hiroshige, Okuda Masato, Iwamoto Kunihiro, Miyata Seiko, Torii Youta, Iritani Shuji, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 72 ( 6 ) page: 423-434   2018.6

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    DOI: 10.1111/pcn.12651

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  142. Driving performance of stable outpatients with depression undergoing real-world treatment

    Miyata Akemi, Iwamoto Kunihiro, Kawano Naoko, Aleksic Branko, Ando Masahiko, Ebe Kazutoshi, Fujita Kiyoshi, Yokoyama Motonori, Akiyama Tsuyoshi, Igarashi Yoshio, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 72 ( 6 ) page: 399-408   2018.6

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    DOI: 10.1111/pcn.12648

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  143. Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder

    Reinbold Celine S., Forstner Andreas J., Hecker Julian, Fullerton Janice M., Hoffmann Per, Hou Liping, Heilbronner Urs, Degenhardt Franziska, Adli Mazda, Akiyama Kazufumi, Akula Nirmala, Ardau Raffaella, Arias Barbara, Backlund Lena, Benabarre Antonio, Bengesser Susanne, Bhattacharjee Abesh K., Biernacka Joanna M., Birner Armin, Marie-Claire Cynthia, Cervantes Pablo, Chen Guo-Bo, Chen Hsi-Chung, Chillotti Caterina, Clark Scott R., Colom Francesc, Cousins David A., Cruceanu Cristiana, Czerski Piotr M., Dayer Alexandre, Etain Bruno, Falkai Peter, Frisen Louise, Gard Sebastien, Garnham Julie S., Goes Fernando S., Grof Paul, Gruber Oliver, Hashimoto Ryota, Hauser Joanna, Herms Stefan, Jamain Stephane, Jimenez Esther, Kahn Jean-Pierre, Kassem Layla, Kittel-Schneider Sarah, Kliwicki Sebastian, Koenig Barbara, Kusumi Ichiro, Lackner Nina, Laje Gonzalo, Landen Mikael, Lavebratt Catharina, Leboyer Marion, Leckband Susan G., Lopez Jaramillo Carlos A., MacQueen Glenda, Manchia Mirko, Martinsson Lina, Mattheisen Manuel, McCarthy Michael J., McElroy Susan L., Mitjans Marina, Mondimore Francis M., Monteleone Palmiero, Nievergelt Caroline M., Osby Urban, Ozaki Norio, Perlis Roy H., Pfennig Andrea, Reich-Erkelenz Daniela, Rouleau Guy A., Schofield Peter R., Schubert K. Oliver, Schweizer Barbara W., Seemueller Florian, Severino Giovanni, Shekhtman Tatyana, Shilling Paul D., Shimoda Kazutaka, Simhandl Christian, Slaney Claire M., Smoller Jordan W., Squassina Alessio, Stamm Thomas J., Stopkova Pavla, Tighe Sarah K., Tortorella Alfonso, Turecki Gustavo, Volkert Julia, Witt Stephanie H., Wright Adam J., Young L. Trevor, Zandi Peter P., Potash James B., DePaulo J. Raymond, Bauer Michael, Reininghaus Eva, Novak Tomas, Aubry Jean-Michel, Maj Mario, Baune Bernhard T., Mitchell Philip B., Vieta Eduard, Frye Mark A., Rybakowski Janusz K., Kuo Po-Hsiu, Kato Tadafumi, Grigoroiu-Serbanescu Maria, Reif Andreas, Del Zompo Maria, Bellivier Frank, Schalling Martin, Wray Naomi R., Kelsoe John R., Alda Martin, McMahon Francis J., Schulze Thomas G., Rietschel Marcella, Nothen Markus M., Cichon Sven

    FRONTIERS IN PSYCHIATRY   Vol. 9   page: 207   2018.5

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    DOI: 10.3389/fpsyt.2018.00207

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  144. Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis

    Mouri Akihiro, Ukai Mayu, Uchida Mizuki, Hasegawa Sho, Taniguchi Masayuki, Ito Takahiro, Hida Hirotake, Yoshimi Akira, Yamada Kiyofumi, Kunimoto Shohko, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro

    NEUROPHARMACOLOGY   Vol. 133   page: 23-37   2018.5

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    DOI: 10.1016/j.neuropharm.2018.01.016

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  145. Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders

    Ishizuka Kanako, Tabata Hidenori, Ito Hidenori, Kushima Itaru, Noda Mariko, Yoshimi Akira, Usami Masahide, Watanabe Kyota, Morikawa Mako, Uno Yota, Okada Takashi, Mori Daisuke, Aleksic Branko, Ozaki Norio, Nagata Koh-ichi

    JOURNAL OF NEUROSCIENCE RESEARCH   Vol. 96 ( 5 ) page: 789-802   2018.5

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    DOI: 10.1002/jnr.24194

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  146. Copy Number Variant in the Region of Adenosine Kinase (ADK) and Its Possible Contribution to Schizophrenia Susceptibility

    Kimura Hiroki, Kushima Itaru, Yohimi Akira, Aleksic Branko, Ozaki Norio

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   Vol. 21 ( 5 ) page: 405-409   2018.5

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    DOI: 10.1093/ijnp/pyx103

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  147. An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Wakabayashi Toshihiko, Kuzuya Masafumi, Ozaki Norio, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Sobue Gen

    NEUROIMAGE   Vol. 169   page: 134-144   2018.4

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    DOI: 10.1016/j.neuroimage.2017.12.014

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  148. A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder

    Ikeda M., Takahashi A., Kamatani Y., Okahisa Y., Kunugi H., Mori N., Sasaki T., Ohmori T., Okamoto Y., Kawasaki H., Shimodera S., Kato T., Yoneda H., Yoshimura R., Iyo M., Matsuda K., Akiyama M., Ashikawa K., Kashiwase K., Tokunaga K., Kondo K., Saito T., Shimasaki A., Kawase K., Kitajima T., Matsuo K., Itokawa M., Someya T., Inada T., Hashimoto R., Inoue T., Akiyama K., Tanii H., Arai H., Kanba S., Ozaki N., Kusumi I., Yoshikawa T., Kubo M., Iwata N.

    MOLECULAR PSYCHIATRY   Vol. 23 ( 3 ) page: 639-647   2018.3

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    DOI: 10.1038/mp.2016.259

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  149. Issues on the diagnosis and etiopathogenesis of mood disorders: reconsidering DSM-5

    Ogasawara Kazuyoshi, Nakamura Yukako, Kimura Hiroyuki, Aleksic Branko, Ozaki Norio

    JOURNAL OF NEURAL TRANSMISSION   Vol. 125 ( 2 ) page: 211-222   2018.2

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    DOI: 10.1007/s00702-017-1828-2

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  150. Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder

    Takata Atsushi, Miyake Noriko, Tsurusaki Yoshinori, Fukai Ryoko, Miyatake Satoko, Koshimizu Eriko, Kushima Itaru, Okada Takashi, Morikawa Mako, Uno Yota, Ishizuka Kanako, Nakamura Kazuhiko, Tsujii Masatsugu, Yoshikawa Takeo, Toyota Tomoko, Okamoto Nobuhiko, Hiraki Yoko, Hashimoto Ryota, Yasuda Yuka, Saitoh Shinji, Ohashi Kei, Sakai Yasunari, Ohga Shouichi, Hara Toshiro, Kato Mitsuhiro, Nakamura Kazuyuki, Ito Aiko, Seiwa Chizuru, Shirahata Emi, Osaka Hitoshi, Matsumoto Ayumi, Takeshita Saoko, Tohyama Jun, Saikusa Tomoko, Matsuishi Toyojiro, Nakamura Takumi, Tsuboi Takashi, Kato Tadafumi, Suzuki Toshifumi, Saitsu Hirotomo, Nakashima Mitsuko, Mizuguchi Takeshi, Tanaka Fumiaki, Mori Norio, Ozaki Norio, Matsumoto Naomichi

    CELL REPORTS   Vol. 22 ( 3 ) page: 734-747   2018.1

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    DOI: 10.1016/j.celrep.2017.12.074

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  151. Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility

    Yu Yanjie, Lin Yingni, Takasaki Yuto, Wang Chenyao, Kimura Hiroki, Xing Jingrui, Ishizuka Kanako, Toyama Miho, Kushima Itaru, Mori Daisuke, Arioka Yuko, Uno Yota, Shiino Tomoko, Nakamura Yukako, Okada Takashi, Morikawa Mako, Ikeda Masashi, Iwata Nakao, Okahisa Yuko, Takaki Manabu, Sakamoto Shinji, Someya Toshiyuki, Egawa Jun, Usami Masahide, Kodaira Masaki, Yoshimi Akira, Oya-Ito Tomoko, Aleksic Branko, Ohno Kinji, Ozaki Norio

    TRANSLATIONAL PSYCHIATRY   Vol. 8 ( 1 ) page: 12   2018.1

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    DOI: 10.1038/s41398-017-0061-y

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  152. Right treatment for the right schizophrenic patients based on carbonyl stress pathophysiology

    Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 72 ( 1 ) page: 2-2   2018.1

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    DOI: 10.1111/pcn.12620

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  153. Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder A Genome-Wide Association Study

    Amare Azmeraw T., Schubert Klaus Oliver, Hou Liping, Clark Scott R., Papiol Sergi, Heilbronner Urs, Degenhardt Franziska, Tekola-Ayele Fasil, Hsu Yi-Hsiang, Shekhtman Tatyana, Adli Mazda, Akula Nirmala, Akiyama Kazufumi, Ardau Raffaella, Arias Barbara, Aubry Jean-Michel, Backlund Lena, Bhattacharjee Abesh Kumar, Bellivier Frank, Benabarre Antonio, Bengesser Susanne, Biernacka Joanna M., Birner Armin, Brichant-Petitjean Clara, Cervantes Pablo, Chen Hsi-Chung, Chillotti Caterina, Cichon Sven, Cruceanu Cristiana, Czerski Piotr M., Dalkner Nina, Dayer Alexandre, Del Zompo Maria, DePaulo J. Raymond, Etain Bruno, Falkai Peter, Forstner Andreas J., Frisen Louise, Frye Mark A., Fullerton Janice M., Gard Sebastien, Garnham Julie S., Goes Fernando S., Grigoroiu-Serbanescu Maria, Grof Paul, Hashimoto Ryota, Hauser Joanna, Herms Stefan, Hoffmann Per, Hofmann Andrea, Jamain Stephane, Jimenez Esther, Kahn Jean-Pierre, Kassem Layla, Kuo Po-Hsiu, Kato Tadafumi, Kelsoe John, Kittel-Schneider Sarah, Kliwicki Sebastian, Koenig Barbara, Kusumi Ichiro, Laje Gonzalo, Landen Mikael, Lavebratt Catharina, Leboyer Marion, Leckband Susan G., Tortorella Alfonso, Manchia Mirko, Martinsson Lina, McCarthy Michael J., McElroy Susan, Colom Francesc, Mitjans Marina, Mondimore Francis M., Monteleone Palmiero, Nievergelt Caroline M., Noethen Markus M., Novak Tomas, O'Donovan Claire, Ozaki Norio, Osby Urban, Pfennig Andrea, Potash James B., Reif Andreas, Reininghaus Eva, Rouleau Guy A., Rybakowski Janusz K., Schalling Martin, Schofield Peter R., Schweizer BarbaraW., Severino Giovanni, Shilling Paul D., Shimoda Katzutaka, Simhandl Christian, Slaney Claire M., Squassina Alessio, Stamm Thomas, Stopkova Pavla, Maj Mario, Turecki Gustavo, Vieta Eduard, Volkert Julia, Witt Stephanie, Wright Adam, Zandi Peter P., Mitchell Philip B., Bauer Michael, Alda Martin, Rietschel Marcella, McMahon Francis J., Schulze Thomas G., Baune Bernhard T.

    JAMA PSYCHIATRY   Vol. 75 ( 1 ) page: 65-74   2018.1

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    DOI: 10.1001/jamapsychiatry.2017.3433

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  154. Successful Post-Transplant Psychiatric Interventions During Long-Term Follow-Up of Patients Receiving Liver Transplants for Alcoholic Liver Disease.

    Kimura H, Onishi Y, Kishi S, Kurata N, Ogiso S, Kamei H, Tsuboi C, Yamaguchi N, Shiga A, Kondo M, Yokoyama Y, Takasato F, Fujishiro H, Ishizuka K, Okada T, Ogura Y, Ozaki N

    The American journal of case reports   Vol. 18   page: 1215-1219   2017.11

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  155. Human neutrophils show decreased survival upon long-term exposure to clozapine

    Goto Aya, Yoshimi Akira, Nagai Tomoko, Ukigai Mako, Mouri Akihiro, Ozaki Norio, Noda Yukihiro

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 32 ( 6 )   2017.11

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    DOI: 10.1002/hup.2629

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  156. Relationship between maternal depression and bonding failure: A prospective cohort study of pregnant women

    Ohara Masako, Okada Takashi, Kubota Chika, Nakamura Yukako, Shiino Tomoko, Aleksic Branko, Morikawa Mako, Yamauchi Aya, Uno Yota, Murase Satomi, Goto Setsuko, Kanai Atsuko, Masuda Tomoko, Ando Masahiko, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 71 ( 10 ) page: 733-741   2017.10

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    DOI: 10.1111/pcn.12541

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  157. Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice

    Matsumoto Yurie, Niwa Minae, Mouri Akihiro, Noda Yukihiro, Fukushima Takeshi, Ozaki Norio, Nabeshima Toshitaka

    PSYCHOPHARMACOLOGY   Vol. 234 ( 20 ) page: 3055-3074   2017.10

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    DOI: 10.1007/s00213-017-4704-8

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  158. Regional decrease in gray matter volume is related to body dissatisfaction in anorexia nervosa

    Kohmura Kunihiro, Adachi Yasunori, Tanaka Satoshi, Katayama Hiroto, Imaeda Miho, Kawano Naoko, Nishioka Kazuo, Ando Masahiko, Iidaka Tetsuya, Ozaki Norio

    PSYCHIATRY RESEARCH-NEUROIMAGING   Vol. 267   page: 51-58   2017.9

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    DOI: 10.1016/j.pscychresns.2017.07.004

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  159. Human neutrophils show decreased survival upon long-term exposure to clozapine

    Goto, A. Yoshimi, A. Nagai, T. Ukigai, M. Mouri, A. Ozaki, N. Noda, Y.

    Hum Psychopharmacol     2017.9

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    DOI: doi.org/10.1002/hup.2629

  160. Verbal Memory impairment in Patients with subsyndromal Bipolar Disorder

    Sumiyoshi Tomiki, Toyomaki Atsuhito, Kawano Naoko, Kitajima Tomoko, Kusumi Ichiro, Ozaki Norio, Iwata Nakao, Sueyoshi Kazuki, Nakagome Kazuyuki

    FRONTIERS IN PSYCHIATRY   Vol. 8   page: 168   2017.9

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    DOI: 10.3389/fpsyt.2017.00168

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  161. Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder

    Lim Elaine T., Uddin Mohammed, De Rubeis Silvia, Chan Yingleong, Kamumbu Anne S., Zhang Xiaochang, D'Gama Alissa M., Kim Sonia N., Hill Robert Sean, Goldberg Arthur P., Poultney Christopher, Minshew Nancy J., Kushima Itaru, Aleksic Branko, Ozaki Norio, Parellada Mara, Arango Celso, Penzol Maria J., Carracedo Angel, Kolevzon Alexander, Hultman Christina M., Weiss Lauren A., Fromer Menachem, Chiocchetti Andreas G., Freitag Christine M., Church George M., Scherer Stephen W., Buxbaum Joseph D., Walsh Christopher A.

    NATURE NEUROSCIENCE   Vol. 20 ( 9 ) page: 1217-+   2017.9

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    DOI: 10.1038/nn.4598

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  162. Social support helps protect against perinatal bonding failure and depression among mothers: a prospective cohort study

    Ohara Masako, Okada Takashi, Aleksic Branko, Morikawa Mako, Kubota Chika, Nakamura Yukako, Shiino Tomoko, Yamauchi Aya, Uno Yota, Murase Satomi, Goto Setsuko, Kanai Atsuko, Masuda Tomoko, Nakatochi Masahiro, Ando Masahiko, Ozaki Norio

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page: 9546   2017.8

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    DOI: 10.1038/s41598-017-08768-3

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  163. A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility

    Kimura H., Fujita Y., Kawabata T., Ishizuka K., Wang C., Iwayama Y., Okahisa Y., Kushima I., Morikawa M., Uno Y., Okada T., Ikeda M., Inada T., Branko A., Mori D., Yoshikawa T., Iwata N., Nakamura H., Yamashita T., Ozaki N.

    TRANSLATIONAL PSYCHIATRY   Vol. 7   2017.8

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    DOI: 10.1038/tp.2017.170

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  164. Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders

    Ishizuka K., Fujita Y., Kawabata T., Kimura H., Iwayama Y., Inada T., Okahisa Y., Egawa J., Usami M., Kushima I., Uno Y., Okada T., Ikeda M., Aleksic B., Mori D., Someya To, Yoshikawa T., Iwata N., Nakamura H., Yamashita T., Ozaki N.

    TRANSLATIONAL PSYCHIATRY   Vol. 7   2017.8

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    DOI: 10.1038/tp.2017.173

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  165. Verbal memory impairments in bipolar disorder: Effect of type of word learning tasks

    Sumiyoshi Tomiki, Toyomaki Atsuhito, Kawano Naoko, Kitajima Tomoko, Kusumi Ichiro, Ozaki Norio, Iwata Nakao, Sueyoshi Kazuki, Nakagome Kazuyuki

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 71 ( 8 ) page: 570-U77   2017.8

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    DOI: 10.1111/pcn.12536

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  166. Enrichment of deleterious variants of mitochondrial DNA polymerase gene (POLG1) in bipolar disorder

    Kasahara Takaoki, Ishiwata Mizuho, Kakiuchi Chihiro, Fuke Satoshi, Iwata Nakao, Ozaki Norio, Kunugi Hiroshi, Minabe Yoshio, Nakamura Kazuhiko, Iwata Yasuhide, Fujii Kumiko, Kanba Shigenobu, Ujike Hiroshi, Kusumi Ichiro, Kataoka Muneko, Matoba Nana, Takata Atsushi, Iwamoto Kazuya, Yoshikawa Takeo, Kato Tadafumi

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 71 ( 8 ) page: 518-529   2017.8

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    DOI: 10.1111/pcn.12496

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  167. Transethnic Replication Study to Assess the Association Between Clozapine-Induced Agranulocytosis/Granulocytopenia and Genes at 12p12.2 in a Japanese Population.

    Saito T, Ikeda M, Hashimoto R, Iwata N, Members of the Clozapine Pharmacogenomics Consortium of Japan are the following., Yamamori H, Yasuda Y, Fujimoto M, Kondo K, Shimasaki A, Kawase K, Miyata M, Mushiroda T, Ozeki T, Kubo M, Fujita K, Kida N, Nakai M, Otsuru T, Fukuji Y, Murakami M, Mizuno K, Shiratsuchi T, Numata S, Ohmori T, Ueno SI, Yada Y, Tanaka S, Kishi Y, Takaki M, Mamoto A, Taniguchi N, Sawa Y, Watanabe H, Noda T, Amano Y, Kimura T, Fukao T, Suwa T, Murai T, Kubota M, Ueda K, Tabuse H, Kanahara N, Kawai N, Nemoto K, Makinodan M, Nishihata Y, Hashimoto N, Kusumi I, Fujii Y, Miyata R, Hirakawa K, Ozaki N

    Biological psychiatry   Vol. 82 ( 1 ) page: e9-e10   2017.7

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    DOI: 10.1016/j.biopsych.2016.12.009

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  168. Reliability and validity of the California Verbal Learning Test-II - Japanese version

    Sumiyoshi Tomiki, Toyomaki Atsuhito, Kawano Naoko, Kitajima Tomoko, Kusumi Ichiro, Ozaki Norio, Iwata Nakao, Nakagome Kazuyuki

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 71 ( 6 ) page: 417-418   2017.6

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    DOI: 10.1111/pcn.12525

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  169. Reliability and validity of the California verbal learning test (CVLT) -II - Japanese version in patients with subsyndromal bipolar disorder

    Sumiyoshi T., Toyomaki A., Kawano N., Kitajima T., Kusumi I., Ozaki N., Iwata N., Nakagome K.

    BIPOLAR DISORDERS   Vol. 19   page: 111-111   2017.5

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  170. Estimated cognitive decline in patients with schizophrenia: A multicenter study

    Fujino Haruo, Sumiyoshi Chika, Yasuda Yuka, Yamamori Hidenaga, Fujimoto Michiko, Fukunaga Masaki, Miura Kenichiro, Takebayashi Yuto, Okada Naohiro, Isomura Shuichi, Kawano Naoko, Toyomaki Atsuhito, Kuga Hironori, Isobe Masanori, Oya Kazuto, Okahisa Yuko, Takaki Manabu, Hashimoto Naoki, Kato Masaki, Onitsuka Toshiaki, Ueno Takefumi, Ohnuma Tohru, Kasai Kiyoto, Ozaki Norio, Sumiyoshi Tomiki, Imura Osamu, Hashimoto Ryota

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 71 ( 5 ) page: 294-300   2017.5

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    DOI: 10.1111/pcn.12474

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  171. REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series

    Fujishiro Hiroshige, Okuda Masato, Iwamoto Kunihiro, Miyata Seiko, Otake Hironao, Noda Akiko, Iritani Shuji, Ozaki Norio

    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY   Vol. 32 ( 4 ) page: 397-406   2017.4

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    DOI: 10.1002/gps.4477

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  172. Neuropeptide Y neuronal network dysfunction in the frontal lobe of a genetic mouse model of schizophrenia

    Morosawa Shunsuke, Iritani Shuji, Fujishiro Hiroshige, Sekiguchi Hirotaka, Torii Youta, Habuchi Chikako, Kuroda Keisuke, Kaibuchi Kozo, Ozaki Norio

    NEUROPEPTIDES   Vol. 62   page: 27-35   2017.4

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    DOI: 10.1016/j.npep.2016.12.010

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  173. Similarity of symptoms between transient epileptic amnesia and Lewy body disease

    Ukai Katsuyuki, Fujishiro Hiroshige, Watanabe Masako, Kosaka Kenji, Ozaki Norio

    PSYCHOGERIATRICS   Vol. 17 ( 2 ) page: 120-125   2017.3

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    DOI: 10.1111/psyg.12199

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  174. Effect of Adjunctive Aripiprazole on Sexual Dysfunction in Schizophrenia: A Preliminary Open-Label Study

    Fujioi Junko, Iwamoto Kunihiro, Banno Masahiro, Kikuchi Tsutomu, Aleksic Branko, Ozaki Norio

    PHARMACOPSYCHIATRY   Vol. 50 ( 2 ) page: 74-78   2017.3

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    DOI: 10.1055/s-0042-116323

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  175. High-resolution copy number variation analysis of schizophrenia in Japan

    Kushima I., Aleksic B., Nakatochi M., Shimamura T., Shiino T., Yoshimi A., Kimura H., Takasaki Y., Wang C., Xing J., Ishizuka K., Oya-Ito T., Nakamura Y., Arioka Y., Maeda T., Yamamoto M., Yoshida M., Noma H., Hamada S., Morikawa M., Uno Y., Okada T., Iidaka T., Iritani S., Yamamoto T., Miyashita M., Kobori A., Arai M., Itokawa M., Cheng M-C, Chuang Y-A, Chen C-H, Suzuki M., Takahashi T., Hashimoto R., Yamamori H., Yasuda Y., Watanabe Y., Nunokawa A., Someya T., Ikeda M., Toyota T., Yoshikawa T., Numata S., Ohmori T., Kunimoto S., Mori D., Iwata N., Ozaki N.

    MOLECULAR PSYCHIATRY   Vol. 22 ( 3 ) page: 430-440   2017.3

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    DOI: 10.1038/mp.2016.88

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  176. Effectiveness of low-dose pregabalin in three patients with Lewy body disease and central neuropathic pain

    Ukai Katsuyuki, Fujishiro Hiroshige, Ozaki Norio

    PSYCHOGERIATRICS   Vol. 17 ( 2 ) page: 115-119   2017.3

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    DOI: 10.1111/psyg.12192

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  177. Risk of alcohol use relapse after liver transplantation for alcoholic liver disease

    Onishi Yasuharu, Kimura Hiroyuki, Hori Tomohide, Kishi Shinichi, Kamei Hideya, Kurata Nobuhiko, Tsuboi Chisato, Yamaguchi Naoko, Takahashi Mayu, Sunada Saki, Hirano Mitsuaki, Fujishiro Hiroshige, Okada Takashi, Ishigami Masatoshi, Goto Hidemi, Ozaki Norio, Ogura Yasuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 23 ( 5 ) page: 869-875   2017.2

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    DOI: 10.3748/wjg.v23.i5.869

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  178. Rapid eye movement sleep without atonia may help diagnose Lewy body disease in middle-aged and older patients with somatic symptom disorder

    Munechika Takayuki, Fujishiro Hiroshige, Okuda Masato, Iwamoto Kunihiro, Torii Youta, Iritani Shuji, Ozaki Norio

    PSYCHOGERIATRICS   Vol. 17 ( 1 ) page: 61-69   2017.1

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    DOI: 10.1111/psyg.12181

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  179. Effect of aripiprazole augmentation for depressive symptoms changes with progression of Lewy body disease

    Iwamoto Kunihiro, Fujishiro Hiroshige, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 71 ( 1 ) page: 74-75   2017.1

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    DOI: 10.1111/pcn.12479

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  180. Influence of sleep duration on cortical oxygenation in elderly individuals

    Kato Kazuko, Miyata Seiko, Ando Motoo, Matsuoka Hiroki, Yasuma Fumihiko, Iwamoto Kunihiro, Kawano Naoko, Banno Masahiro, Ozaki Norio, Noda Akiko

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 71 ( 1 ) page: 44-51   2017.1

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    DOI: 10.1111/pcn.12464

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  181. Schizophrenia polygenic risk score and prepubertal developmental impairments

    Aleksic Branko, Ozaki Norio

    LANCET PSYCHIATRY   Vol. 4 ( 1 ) page: 7-8   2017.1

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    DOI: 10.1016/S2215-0366(16)30409-6

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  182. Current Viewpoints on DSM-5 in Japan

    Kuroki T, Ishitobi M, Kamio Y, Sugihara G, Murai T, Motomura K, Ogasawara K, Kimura H, Aleksic B, Ozaki N, Nakao T, Yamada K, Yoshiuchi K, Kiriike N, Ishikawa T, Kubo C, Matsunaga C, Miyata H, Asada T, Kanba S

    Psychiatry Clin Neurosci   Vol. 70 ( 9 ) page: 371-393   2016.9

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    DOI: 10.1111/pcn.12421

  183. Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population Reviewed

    Kimura Hiroki, Tanaka Satoshi, Kushima Itaru, Koide Takayoshi, Banno Masahiro, Kikuchi Tsutomu, Nakamura Yukako, Shiino Tomoko, Yoshimi Akira, Oya-Ito Tomoko, Xing Jingrui, Wang Chenyao, Takasaki Yuto, Aleksic Branko, Okada Takashi, Ikeda Masashi, Inada Toshiya, Iidaka Tetsuya, Iwata Nakao, Ozaki Norio

    SCIENTIFIC REPORTS   Vol. 5   2015.10

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    DOI: 10.1038/srep15705

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  184. White matter microstructure between the pre-SMA and the cingulum bundle is related to response conflict in healthy subjects Reviewed

    Yamamoto Maeri, Kushima Itaru, Kimura Hiroki, Hayashi Akiko, Kawano Naoko, Aleksic Branko, Iidaka Tetsuya, Ozaki Norio

    BRAIN AND BEHAVIOR   Vol. 5 ( 10 )   2015.10

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    DOI: 10.1002/brb3.375

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  185. Autopsy-confirmed hippocampal-sparing Alzheimer's disease with delusional jealousy as initial manifestation Reviewed

    Fujishiro Hiroshige, Iritani Shuji, Hattori Miho, Sekiguchi Hirotaka, Matsunaga Shinji, Habuchi Chikako, Torii Youta, Umeda Kentaro, Ozaki Norio, Yoshida Mari, Fujita Kiyoshi

    PSYCHOGERIATRICS   Vol. 15 ( 3 ) page: 198-203   2015.9

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    DOI: 10.1111/psyg.12105

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  186. Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies Reviewed

    Nishizawa Daisuke, Kasai Shinya, Hasegawa Junko, Sato Naomi, Yamada Hidetaka, Tanioka Fumihiko, Nagashima Makoto, Katoh Ryoji, Satoh Yasuo, Tagami Megumi, Ujike Hiroshi, Ozaki Norio, Inada Toshiya, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Yamada Mitsuhiko, Kondo Naoki, Won Moo-Jun, Naruse Nobuya, Uehara-Aoyama Kumi, Itokawa Masanari, Ohi Kazutaka, Hashimoto Ryota, Tanisawa Kumpei, Arai Tomio, Mori Seijiro, Sawabe Motoji, Naka-Mieno Makiko, Yamada Yoshiji, Yamada Miki, Sato Noriko, Muramatsu Masaaki, Tanaka Masashi, Irukayama-Tomobe Yoko, Saito Yuki C., Sakurai Takeshi, Hayashida Masakazu, Sugimura Haruhiko, Ikeda Kazutaka

    MOLECULAR BRAIN   Vol. 8   2015.8

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    DOI: 10.1186/s13041-015-0142-x

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  187. Glia-related genes and their contribution to schizophrenia Reviewed

    Wang Chenyao, Aleksic Branko, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 69 ( 8 ) page: 448-461   2015.8

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    DOI: 10.1111/pcn.12290

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  188. The effects of acute treatment with ramelteon, triazolam, and placebo on driving performance, cognitive function, and equilibrium function in healthy volunteers Reviewed

    Miyata Akemi, Iwamoto Kunihiro, Kawano Naoko, Kohmura Kunihiro, Yamamoto Maeri, Aleksic Branko, Ebe Kazutoshi, Noda Akiko, Noda Yukihiro, Iritani Shuji, Ozaki Norio

    PSYCHOPHARMACOLOGY   Vol. 232 ( 12 ) page: 2127-2137   2015.6

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    DOI: 10.1007/s00213-014-3843-4

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  189. Long-term efficacy of donepezil for relapse of visual hallucinations in patients with dementia with Lewy bodies Reviewed

    Ukai Katsuyuki, Fujishiro Hiroshige, Iritani Shuji, Ozaki Norio

    PSYCHOGERIATRICS   Vol. 15 ( 2 ) page: 133-137   2015.6

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    DOI: 10.1111/psyg.12089

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  190. No support for replication of the genetic variants identified by a recent mega-analysis of the treatment response to antidepressants Reviewed

    Hatano Masakazu, Ikeda Masashi, Kondo Kenji, Saito Takeo, Shimasaki Ayu, Esaki Kosei, Umene-Nakano Wakako, Yoshimura Reiji, Nakamura Jun, Ozaki Norio, Iwata Nakao

    JOURNAL OF HUMAN GENETICS   Vol. 60 ( 6 ) page: 343-344   2015.6

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    DOI: 10.1038/jhg.2015.21

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  191. Relationship between social support during pregnancy and postpartum depressive state: a prospective cohort study Reviewed

    Morikawa Mako, Okada Takashi, Ando Masahiko, Aleksic Branko, Kunimoto Shohko, Nakamura Yukako, Kubota Chika, Uno Yota, Tamaji Ai, Hayakawa Norika, Furumura Kaori, Shiino Tomoko, Morita Tokiko, Ishikawa Naoko, Ohoka Harue, Usui Hinako, Banno Naomi, Murase Satomi, Goto Setsuko, Kanai Atsuko, Masuda Tomoko, Ozaki Norio

    SCIENTIFIC REPORTS   Vol. 5   2015.5

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    DOI: 10.1038/srep10520

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  192. Early exposure to the combined measles-mumps-rubella vaccine and thimerosal-containing vaccines and risk of autism spectrum disorder Reviewed

    Uno Yota, Uchiyama Tokio, Kurosawa Michiko, Aleksic Branko, Ozaki Norio

    VACCINE   Vol. 33 ( 21 ) page: 2511-2516   2015.5

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    DOI: 10.1016/j.vaccine.2014.12.036

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  193. Temperament and character profiles of patients with burning mouth syndrome Reviewed

    Tokura Tatsuya, Kimura Hiroyuki, Ito Mikiko, Nagashima Wataru, Sato Naohiro, Kimura Yuki, Arao Munetaka, Aleksic Branko, Yoshida Keizo, Kurita Kenichi, Ozaki Norio

    JOURNAL OF PSYCHOSOMATIC RESEARCH   Vol. 78 ( 5 ) page: 495-498   2015.5

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    DOI: 10.1016/j.jpsychores.2015.02.006

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  194. Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility Reviewed

    Kimura Hiroki, Tsuboi Daisuke, Wang Chenyao, Kushima Itaru, Koide Takayoshi, Ikeda Masashi, Iwayama Yoshimi, Toyota Tomoko, Yamamoto Noriko, Kunimoto Shohko, Nakamura Yukako, Yoshimi Akira, Banno Masahiro, Xing Jingrui, Takasaki Yuto, Yoshida Mami, Aleksic Branko, Uno Yota, Okada Takashi, Iidaka Tetsuya, Inada Toshiya, Suzuki Michio, Ujike Hiroshi, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Iwata Nakao, Kaibuchi Kozo, Ozaki Norio

    SCHIZOPHRENIA BULLETIN   Vol. 41 ( 3 ) page: 744-753   2015.5

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    DOI: 10.1093/schbul/sbu147

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  195. Novel Rare Missense Variations and Risk of Autism Spectrum Disorder: Whole-Exome Sequencing in Two Families with Affected Siblings and a Two-Stage Follow-Up Study in a Japanese Population Reviewed

    Egawa Jun, Watanabe Yuichiro, Wang Chenyao, Inoue Emiko, Sugimoto Atsunori, Sugiyama Toshiro, Igeta Hirofumi, Nunokawa Ayako, Shibuya Masako, Kushima Itaru, Orime Naoki, Hayashi Taketsugu, Okada Takashi, Uno Yota, Ozaki Norio, Someya Toshiyuki

    PLOS ONE   Vol. 10 ( 3 )   2015.3

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    DOI: 10.1371/journal.pone.0119413

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  196. What is the nature of the autism 'spectrum'? Reviewed

    Okada Takashi, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 69 ( 3 ) page: 129-130   2015.3

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    DOI: 10.1111/pcn.12276

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  197. Genetic Overlap Between Antipsychotic Response and Susceptibility to Schizophrenia Reviewed

    Ikeda Masashi, Yoshimura Reiji, Hashimoto Ryota, Kondo Kenji, Saito Takeo, Shimasaki Ayu, Ohi Kazutaka, Tochigi Mamoru, Kawamura Yoshiya, Nishida Nao, Miyagawa Taku, Sasaki Tsukasa, Tokunaga Katsushi, Kasai Kiyoto, Takeda Masatoshi, Nakamura Jun, Ozaki Norio, Iwata Nakao

    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY   Vol. 35 ( 1 ) page: 85-88   2015.2

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  198. Blonanserin Ameliorates Phencyclidine-Induced Visual-Recognition Memory Deficits: the Complex Mechanism of Blonanserin Action Involving D-3-5-HT2A and D-I-NMDA Receptors in the mPFC Reviewed

    Hida Hirotake, Mouri Akihiro, Mori Kentaro, Matsumoto Yurie, Seki Takeshi, Taniguchi Masayuki, Yamada Kiyofumi, Iwamoto Kunihiro, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro

    NEUROPSYCHOPHARMACOLOGY   Vol. 40 ( 3 ) page: 601-613   2015.2

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    DOI: 10.1038/npp.2014.207

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  199. The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects Reviewed

    Takahashi Tsutomu, Nakamura Mihoko, Nakamura Yukako, Aleksic Branko, Kido Mikio, Sasabayashi Daiki, Takayanagi Yoichiro, Furuichi Atsushi, Nishikawa Yumiko, Noguchi Kyo, Ozaki Norio, Suzuki Michio

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   Vol. 56   page: 11-17   2015.1

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    DOI: 10.1016/j.pnpbp.2014.07.005

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  200. Efficacy of aripiprazole augmentation in Japanese patients with major depressive disorder: A subgroup analysis and Montgomery-Asberg Depression Rating Scale and Hamilton Rating Scale for Depression item analyses of the Aripiprazole Depression Multicenter Efficacy study Reviewed

    Ozaki Norio, Otsubo Tempei, Kato Masaki, Higuchi Teruhiko, Ono Hiroaki, Kamijima Kunitoshi

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 69 ( 1 ) page: 34-42   2015.1

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    DOI: 10.1111/pcn.12214

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  201. Five Patients With Burning Mouth Syndrome in Whom an Antidepressant (Serotonin-Noradrenaline Reuptake Inhibitor) Was Not Effective, but Pregabalin Markedly Relieved Pain Reviewed

    Ito Mikiko, Tokura Tatsuya, Yoshida Keizo, Nagashima Wataru, Kimura Hiroyuki, Umemura Eri, Tachibana Masako, Miyauchi Tomoya, Kobayashi Yuka, Arao Munetaka, Ozaki Norio, Kurita Kenichi

    CLINICAL NEUROPHARMACOLOGY   Vol. 38 ( 4 ) page: 158-161   2015

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    DOI: 10.1097/WNF.0000000000000093

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  202. Synaptic, transcriptional and chromatin genes disrupted in autism Reviewed

    De Rubeis Silvia, He Xin, Goldberg Arthur P., Poultney Christopher S., Samocha Kaitlin, Cicek A. Ercument, Kou Yan, Liu Li, Fromer Menachem, Walker Susan, Singh Tarjinder, Klei Lambertus, Kosmicki Jack, Fu Shih-Chen, Aleksic Branko, Biscaldi Monica, Bolton Patrick F., Brownfeld Jessica M., Cai Jinlu, Campbell Nicholas G., Carracedo Angel, Chahrour Maria H., Chiocchetti Andreas G., Coon Hilary, Crawford Emily L., Crooks Lucy, Curran Sarah R., Dawson Geraldine, Duketis Eftichia, Fernandez Bridget A., Gallagher Louise, Geller Evan, Guter Stephen J., Hill R. Sean, Ionita-Laza Iuliana, Gonzalez Patricia Jimenez, Kilpinen Helena, Klauck Sabine M., Kolevzon Alexander, Lee Irene, Lei Jing, Lehtimaeki Terho, Lin Chiao-Feng, Ma'ayan Avi, Marshall Christian R., McInnes Alison L., Neale Benjamin, Owen Michael J., Ozaki Norio, Parellada Mara, Parr Jeremy R., Purcell Shaun, Puura Kaija, Rajagopalan Deepthi, Rehnstrom Karola, Reichenberg Abraham, Sabo Aniko, Sachse Michael, Sanders Stephan J., Schafer Chad, Schulte-Ruether Martin, Skuse David, Stevens Christine, Szatmari Peter, Tammimies Kristiina, Valladares Otto, Voran Annette, Wang Li-San, Weiss Lauren A., Willsey A. Jeremy, Yu Timothy W., Yuen Ryan K. C., Cook Edwin H., Freitag Christine M., Gill Michael, Hultman Christina M., Lehner Thomas, Palotie Aarno, Schellenberg Gerard D., Skiar Pamela, State Matthew W., Sutcliffe James S., Walsh Christopher A., Scherer Stephen W., Zwick Michael E., Barrett Jeffrey C., Cutler David J., Roeder Kathryn, Devlin Bernie, Daly Mark J., Buxbaum Joseph D.

    NATURE   Vol. 515 ( 7526 ) page: 209-U119   2014.11

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    DOI: 10.1038/nature13772

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  203. Resequencing and Association Analysis of PTPRA, a Possible Susceptibility Gene for Schizophrenia and Autism Spectrum Disorders Reviewed

    Xing Jingrui, Wang Chenyao, Kimura Hiroki, Takasaki Yuto, Kunimoto Shohko, Yoshimi Akira, Nakamura Yukako, Koide Takayoshi, Banno Masahiro, Kushima Itaru, Uno Yota, Okada Takashi, Aleksic Branko, Ikeda Masashi, Iwata Nakao, Ozaki Norio

    PLOS ONE   Vol. 9 ( 11 )   2014.11

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    DOI: 10.1371/journal.pone.0112531

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  204. Common variants at 1p36 are associated with superior frontal gyrus volume Reviewed

    Hashimoto R., Ikeda M., Yamashita F., Ohi K., Yamamori H., Yasuda Y., Fujimoto M., Fukunaga M., Nemoto K., Takahashi T., Tochigi M., Onitsuka T., Yamasue H., Matsuo K., Iidaka T., Iwata N., Suzuki M., Takeda M., Kasai K., Ozaki N.

    TRANSLATIONAL PSYCHIATRY   Vol. 4   2014.10

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    DOI: 10.1038/tp.2014.110

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  205. The Polymorphism of YWHAE, a Gene Encoding 14-3-3Epsilon, and Brain Morphology in Schizophrenia: A Voxel-Based Morphometric Study Reviewed

    Kido Mikio, Nakamura Yukako, Nemoto Kiyotaka, Takahashi Tsutomu, Aleksic Branko, Furuichi Atsushi, Nakamura Yumiko, Ikeda Masashi, Noguchi Kyo, Kaibuchi Kozo, Iwata Nakao, Ozaki Norio, Suzuki Michio

    PLOS ONE   Vol. 9 ( 8 )   2014.8

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    DOI: 10.1371/journal.pone.0103571

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  206. Factor Structure of the Japanese Version of the Edinburgh Postnatal Depression Scale in the Postpartum Period Reviewed

    Kubota Chika, Okada Takashi, Aleksic Branko, Nakamura Yukako, Kunimoto Shohko, Morikawa Mako, Shiino Tomoko, Tamaji Ai, Ohoka Harue, Banno Naomi, Morita Tokiko, Murase Satomi, Goto Setsuko, Kanai Atsuko, Masuda Tomoko, Ando Masahiko, Ozaki Norio

    PLOS ONE   Vol. 9 ( 8 )   2014.8

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    DOI: 10.1371/journal.pone.0103941

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  207. Novel rare variants in F-box protein 45 (FBXO45) in schizophrenia Reviewed

    Wang Chenyao, Koide Takayoshi, Kimura Hiroki, Kunimoto Shohko, Yoshimi Akira, Nakamura Yukako, Kushima Itaru, Banno Masahiro, Kawano Naoko, Takasaki Yuto, Xing Jingrui, Noda Yukihiro, Mouri Akihiro, Aleksic Branko, Ikeda Masashi, Okada Takashi, Iidaka Tetsuya, Inada Toshiya, Iwata Nakao, Ozaki Norio

    SCHIZOPHRENIA RESEARCH   Vol. 157 ( 1-3 ) page: 149-156   2014.8

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    DOI: 10.1016/j.schres.2014.04.032

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  208. Effects of maternal depressive symptomatology during pregnancy and the postpartum period on infant-mother attachment Reviewed

    Ohoka Harue, Koide Takayoshi, Goto Setsuko, Murase Satomi, Kanai Atsuko, Masuda Tomoko, Aleksic Branko, Ishikawa Naoko, Furumura Kaori, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 68 ( 8 ) page: 631-639   2014.8

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    DOI: 10.1111/pcn.12171

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  209. Replication and Cross-Phenotype Study Based Upon Schizophrenia GWASs Data in the japanese Population: Support for Association of MHC Region with Psychosis Reviewed

    Saito Takeo, Kondo Kenji, Iwayama Yoshimi, Shimasaki Ayu, Aleksic Branko, Yamada Kazuo, Toyota Tomoko, Hattori Eiji, Esaki Kosei, Ujike Hiroshi, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ozaki Norio, Ikeda Masashi, Iwata Nakao

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 165 ( 5 ) page: 421-427   2014.7

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    DOI: 10.1002/ajmg.b.32246

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  210. Reliability and Validity of the New Tanaka B Intelligence Scale Scores: A Group Intelligence Test Reviewed

    Uno Yota, Mizukami Hitomi, Ando Masahiko, Yukihiro Ryoji, Iwasaki Yoko, Ozaki Norio

    PLOS ONE   Vol. 9 ( 6 )   2014.6

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    DOI: 10.1371/journal.pone.0100262

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  211. Social insecurity in relation to orbitofrontal activity in patients with eating disorders: a near-infrared spectroscopy study Reviewed

    Katayama Hiroto, Kohmura Kunihiro, Tanaka Satoshi, Imaeda Miho, Kawano Naoko, Noda Yukihiro, Nishioka Kazuo, Ando Masahiko, Aleksic Branko, Iidaka Tetsuya, Ozaki Norio

    BMC PSYCHIATRY   Vol. 14   2014.6

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    DOI: 10.1186/1471-244X-14-173

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  212. The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects Reviewed

    Takahashi Tsutomu, Nakamura Yumiko, Nakamura Yukako, Aleksic Branko, Takayanagi Yoichiro, Furuichi Atsushi, Kido Mikio, Nakamura Mihoko, Sasabayashi Daiki, Ikeda Masashi, Noguchi Kyo, Kaibuchi Kozo, Iwata Nakao, Ozaki Norio, Suzuki Michio

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   Vol. 51   page: 166-171   2014.6

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    DOI: 10.1016/j.pnpbp.2014.02.005

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  213. Plasma dehydroepiandrosterone sulfate levels in patients with major depressive disorder correlate with remission during treatment with antidepressants Reviewed

    Morita Tokiko, Senzaki Koji, Ishihara Ryoko, Umeda Kazunori, Iwata Nakao, Nagai Taku, Hida Hirotake, Nabeshima Toshitaka, Yukawa Kazunori, Ozaki Norio, Noda Yukihiro

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 29 ( 3 ) page: 280-286   2014.5

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    DOI: 10.1002/hup.2400

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  214. Preoperative Level of Depression is a Predictor of Postoperative Levels of Depression in Patients with Head and Neck Cancer Reviewed

    Adachi Yasunori, Kimura Hiroyuki, Sato Naohiro, Nagashima Wataru, Nakamura Kouki, Aleksic Branko, Yoshida Keizo, Fujimoto Yasushi, Nakashima Tsutomu, Ozaki Norio

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 44 ( 4 ) page: 311-317   2014.4

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    DOI: 10.1093/jjco/hyu002

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  215. Copy-number variation in the pathogenesis of autism spectrum disorder Reviewed

    Shishido Emiko, Aleksic Branko, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 68 ( 2 ) page: 85-95   2014.2

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    DOI: 10.1111/pcn.12128

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  216. Combination of neonatal PolyI:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice Reviewed

    Hida Hirotake, Mouri Akihiro, Ando Yu, Mori Kentaro, Mamiya Takayoshi, Iwamoto Kunihiro, Ozaki Norio, Yamada Kiyofumi, Nabeshima Toshitaka, Noda Yukihiro

    BEHAVIOURAL BRAIN RESEARCH   Vol. 258   page: 34-42   2014.1

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    DOI: 10.1016/j.bbr.2013.09.026

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  217. The effects of acute treatment with paroxetine, amitriptyline, and placebo on the equilibrium function in healthy subjects: A double-blind crossover trial Reviewed

    Miyata Seiko, Noda Akiko, Iwamoto Kunihiro, Takahashi Masahiro, Hara Yuki, Kojima Jun, Iidaka Tetsuya, Ozaki Norio

    INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE   Vol. 18 ( 1 ) page: 32-36   2014.1

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    DOI: 10.3109/13651501.2013.813551

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  218. Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population Reviewed

    Kajio Yusuke, Kondo Kenji, Saito Takeo, Iwayama Yoshimi, Aleksic Branko, Yamada Kazuo, Toyota Tomoko, Hattori Eiji, Ujike Hiroshi, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ozaki Norio, Ikeda Masashi, Iwata Nakao

    JOURNAL OF HUMAN GENETICS   Vol. 59 ( 1 ) page: 54-56   2014.1

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    DOI: 10.1038/jhg.2013.116

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  219. Genome-wide association study identifies a potent locus associated with human opioid sensitivity Reviewed

    Nishizawa D., Fukuda K., Kasai S., Hasegawa J., Aoki Y., Nishi A., Saita N., Koukita Y., Nagashima M., Katoh R., Satoh Y., Tagami M., Higuchi S., Ujike H., Ozaki N., Inada T., Iwata N., Sora I., Iyo M., Kondo N., Won M-J, Naruse N., Uehara-Aoyama K., Itokawa M., Koga M., Arinami T., Kaneko Y., Hayashida M., Ikeda K.

    MOLECULAR PSYCHIATRY   Vol. 19 ( 1 ) page: 55-62   2014.1

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    DOI: 10.1038/mp.2012.164

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  220. Replication of enhanced carbonyl stress in a subpopulation of schizophrenia Reviewed

    Miyashita Mitsuhiro, Arai Makoto, Yuzawa Hiroko, Niizato Kazuhiro, Oshima Kenichi, Kushima Itaru, Hashimoto Ryota, Fukumoto Motoyuki, Koike Shinsuke, Toyota Tomoko, Ujike Hiroshi, Arinami Tadao, Kasai Kiyoto, Takeda Masatoshi, Ozaki Norio, Okazaki Yuji, Yoshikawa Takeo, Amano Naoji, Miyata Toshio, Itokawa Masanari

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 68 ( 1 ) page: 83-84   2014.1

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    DOI: 10.1111/pcn.12087

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  221. The possibility of prostaglandin E-2 (PGE(2)) as a common molecule associated with vulnerability to neurodevelopmental disruptions Reviewed

    Hida Hirotake, Mouri Akihiro, Mori Kentaro, Furuyashiki Tomoyuki, Yamada Kiyofumi, Ozaki Norio, Narumiya Shuh, Nabeshima Toshitaka, Noda Yukihiro

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 124   page: 75P-75P   2014

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  222. The intronic SNP of PCLO is associated with dependence-like behavior in genomic association syudy, and regulates DA and 5-HT uptake in the cultured cells Reviewed

    Uno Kyosuke, Nishizawa Daisuke, Seo Seunghee, Takayama Kanako, Matsumura Shohei, Sakai Norio, Ohi Kazutaka, Nabeshima Toshitaka, Ryota Hashimoto, Ozaki Norio, Ikeda Kazutaka, Miyamoto Yoshiaki, Nitta Atsumi

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 124   page: 183P-183P   2014

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  223. The role of glial glutamate transporter (GLAST) in psychobehavioral abnormalities following repeated administration of phencyclidine Reviewed

    Mori Kentaro, Matsumoto Yurie, Hida Hirotake, Mouri Akihiro, Yamada Kiyofumi, Ozaki Norio, Tanaka Kohichi, Nabeshima Toshitaka, Noda Yukihiro

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 124   page: 215P-215P   2014

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  224. The role of glial glutamate transporter (GLAST) in cognitive functions in mice Reviewed

    Noda Yukihiro, Hasegawa Shoh, Taniguchi Masayuki, Hida Hirotake, Mouri Akihiro, Kunimoto Masako, Yamada Kiyofumi, Ozaki Norio, Tanaka Kohichi, Nabeshima Toshitaka

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 124   page: 212P-212P   2014

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  225. Aripiprazole augmentation to antidepressant therapy in Japanese patients with major depressive disorder: A randomized, double-blind, placebo-controlled study (ADMIRE study) Reviewed

    Kamijima Kunitoshi, Higuchi Teruhiko, Ishigooka Jun, Ohmori Tetsuro, Ozaki Norio, Kanba Shigenobu, Kinoshita Toshihiko, Koyama Tsukasa

    JOURNAL OF AFFECTIVE DISORDERS   Vol. 151 ( 3 ) page: 899-905   2013.12

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    DOI: 10.1016/j.jad.2013.07.035

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  226. Replication in a Japanese population that a MIR30E gene variation is associated with schizophrenia Reviewed

    Watanabe Yuichiro, Iijima Yoshimi, Egawa Jun, Nunokawa Ayako, Kaneko Naoshi, Arinami Tadao, Ujike Hiroshi, Inada Toshiya, Iwata Nakao, Kunugi Hiroshi, Itokawa Masanari, Sasaki Tsukasa, Ozaki Norio, Hashimoto Ryota, Shibuya Masako, Igeta Hirofumi, Someya Toshiyuki

    SCHIZOPHRENIA RESEARCH   Vol. 150 ( 2-3 ) page: 596-597   2013.11

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    DOI: 10.1016/j.schres.2013.08.028

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  227. Functional Analysis of Deep Intronic SNP rs13438494 in Intron 24 of PCLO Gene Reviewed

    Seo Seunghee, Takayama Kanako, Uno Kyosuke, Ohi Kazutaka, Hashimoto Ryota, Nishizawa Daisuke, Ikeda Kazutaka, Ozaki Norio, Nabeshima Toshitaka, Miyamoto Yoshiaki, Nitta Atsumi

    PLOS ONE   Vol. 8 ( 10 )   2013.10

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    DOI: 10.1371/journal.pone.0076960

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  228. Poor sleep quality impairs cognitive performance in older adults Reviewed

    Miyata Seiko, Noda Akiko, Iwamoto Kunihiro, Kawano Naoko, Okuda Masato, Ozaki Norio

    JOURNAL OF SLEEP RESEARCH   Vol. 22 ( 5 ) page: 535-541   2013.10

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    DOI: 10.1111/jsr.12054

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  229. COMMON VARIANTS IN BCL9 GENE AND SCHIZOPHRENIA IN A JAPANESE POPULATION: ASSOCIATION STUDY, META-ANALYSIS AND COGNITIVE FUNCTION ANALYSIS Reviewed

    Shiino Tomoko, Koide Takayoshi, Kushima Itaru, Ikeda Masashi, Kunimoto Shohko, Nakamura Yukako, Yoshimi Akira, Aleksic Branko, Banno Masahiro, Kikuchi Tsutomu, Kohmura Kunihiro, Adachi Yasunori, Kawano Naoko, Okada Takashi, Inada Toshiya, Ujike Hiroshi, Iidaka Tetsuya, Suzuki Michio, Iwata Nakao, Ozaki Norio

    JOURNAL OF MEDICAL BIOCHEMISTRY   Vol. 32 ( 4 ) page: 361-367   2013.10

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    DOI: 10.2478/jomb-2013-0049

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  230. Lack of association of EGR2 variants with bipolar disorder in Japanese population Reviewed

    Balan Shabeesh, Yamada Kazuo, Iwayama Yoshimi, Toyota Tomoko, Ohnishi Tetsuo, Maekawa Motoko, Toyoshima Manabu, Iwata Yasuhide, Suzuki Katsuald, Kikuchi Mitsuru, Ujike Hiroshi, Inada Toshiya, Kunugi Hiroshi, Ozaki Norio, Iwata Nakao, Nanko Shinichiro, Kato Tadafumi, Yoshikawa Takeo

    GENE   Vol. 526 ( 2 ) page: 246-250   2013.9

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    DOI: 10.1016/j.gene.2013.05.055

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  231. Definition and refinement of the 7q36.3 duplication region associated with schizophrenia Reviewed

    Aleksic Branko, Kushima Itaru, Ohye Tamae, Ikeda Masashi, Kunimoto Shohko, Nakamura Yukako, Yoshimi Akira, Koide Takayoshi, Iritani Shuji, Kurahashi Hiroki, Iwata Nakao, Ozaki Norio

    SCIENTIFIC REPORTS   Vol. 3   2013.9

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    DOI: 10.1038/srep02587

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  232. Evidence for Shared Genetic Risk Between Methamphetamine-Induced Psychosis and Schizophrenia Reviewed

    Ikeda Masashi, Okahisa Yuko, Aleksic Branko, Won Mujun, Kondo Naoki, Naruse Nobuya, Aoyama-Uehara Kumi, Sora Ichiro, Iyo Masaomi, Hashimoto Ryota, Kawamura Yoshiya, Nishida Nao, Miyagawa Taku, Takeda Masatoshi, Sasaki Tsukasa, Tokunaga Katsushi, Ozaki Norio, Ujike Hiroshi, Iwata Nakao

    NEUROPSYCHOPHARMACOLOGY   Vol. 38 ( 10 ) page: 1864-1870   2013.9

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    DOI: 10.1038/npp.2013.94

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  233. Effects of low-dose mirtazapine on driving performance in healthy volunteers Reviewed

    Iwamoto Kunihiro, Kawano Naoko, Sasada Kazumi, Kohmura Kunihiro, Yamamoto Maeri, Ebe Kazutoshi, Noda Yukihiro, Ozaki Norio

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 28 ( 5 ) page: 523-528   2013.9

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    DOI: 10.1002/hup.2327

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  234. Genetic Variants on 3q21 and in the Sp8 Transcription Factor Gene (SP8) as Susceptibility Loci for Psychotic Disorders: A Genetic Association Study Reviewed

    Kondo Kenji, Ikeda Masashi, Kajio Yusuke, Saito Takeo, Iwayama Yoshimi, Aleksic Branko, Yamada Kazuo, Toyota Tomoko, Hattori Eiji, Ujike Hiroshi, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ozaki Norio, Iwata Nakao

    PLOS ONE   Vol. 8 ( 8 )   2013.8

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    DOI: 10.1371/journal.pone.0070964

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  235. An association analysis of the cardiomyopathy-associated 5 (CMYA5) gene with schizophrenia in a Japanese population Reviewed

    Furukawa Masaomi, Tochigi Mamoru, Otowa Takeshi, Arinami Tadao, Inada Toshiya, Ujike Hiroshi, Watanabe Yuichiro, Iwata Nakao, Itokawa Masanari, Kunugi Hiroshi, Hashimoto Ryota, Ozaki Norio, Kakiuchi Chihiro, Kasai Kiyoto, Sasaki Tsukasa

    PSYCHIATRIC GENETICS   Vol. 23 ( 4 ) page: 179-180   2013.8

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    DOI: 10.1097/YPG.0b013e328360c8be

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  236. Further evidence of an association between a genetic variant in BMP7 and treatment response to SSRIs in major depressive disorder Reviewed

    Esaki Kosei, Kondo Kenji, Hatano Masakazu, Saito Takeo, Kishi Taro, Umene-Nakano Wakako, Yoshimura Reiji, Nakamura Jun, Ozaki Norio, Ikeda Masashi, Iwata Nakao

    JOURNAL OF HUMAN GENETICS   Vol. 58 ( 8 ) page: 568-569   2013.8

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    DOI: 10.1038/jhg.2013.52

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  237. Necessity of normative data on the Japanese version of the Wechsler Memory Scale-Revised Logical Memory subtest for old-old people Reviewed

    Kawano Naoko, Awata Shuichi, Ijuin Mutsuo, Iwamoto Kunihiro, Ozaki Norio

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 13 ( 3 ) page: 726-730   2013.7

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    DOI: 10.1111/ggi.12007

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  238. Maternal overprotection score of the Parental Bonding Instrument predicts the outcome of cognitive behavior therapy by trainees for depression Reviewed

    Asano Motoshi, Esaki Kosei, Wakamatsu Aya, Kitajima Tomoko, Narita Tomohiro, Naitoh Hiroshi, Ozaki Norio, Iwata Nakao

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 67 ( 5 ) page: 340-344   2013.7

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    DOI: 10.1111/pcn.12054

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  239. Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report Reviewed

    Manchia Mirko, Adli Mazda, Akula Nirmala, Ardau Raffaella, Aubry Jean-Michel, Backlund Lena, Banzato Claudio E. M., Baune Bernhard T., Bellivier Frank, Bengesser Susanne, Biernacka Joanna M., Brichant-Petitjean Clara, Bui Elise, Calkin Cynthia V., Cheng Andrew Tai Ann, Chillotti Caterina, Cichon Sven, Clark Scott, Czerski Piotr M., Dantas Clarissa, Del Zompo Maria, DePaulo J. Raymond, Detera-Wadleigh Sevilla D., Etain Bruno, Falkai Peter, Frisen Louise, Frye Mark A., Fullerton Jan, Gard Sebastien, Garnham Julie, Goes Fernando S., Grof Paul, Gruber Oliver, Hashimoto Ryota, Hauser Joanna, Heilbronner Urs, Hoban Rebecca, Hou Liping, Jamain Stephane, Kahn Jean-Pierre, Kassem Layla, Kato Tadafumi, Kelsoe John R., Kittel-Schneider Sarah, Kliwicki Sebastian, Kuo Po-Hsiu, Kusumi Ichiro, Laje Gonzalo, Lavebratt Catharina, Leboyer Marion, Leckband Susan G., Lopez Jaramillo Carlos A., Maj Mario, Malafosse Alain, Martinsson Lina, Masui Takuya, Mitchell Philip B., Mondimore Frank, Monteleone Palmiero, Nallet Audrey, Neuner Maria, Novak Tomas, O'Donovan Claire, Osby Urban, Ozaki Norio, Perlis Roy H., Pfennig Andrea, Potash James B., Reich-Erkelenz Daniela, Reif Andreas, Reininghaus Eva, Richardson Sara, Rouleau Guy A., Rybakowski Janusz K., Schalling Martin, Schofield Peter R., Schubert Oliver K., Schweizer Barbara, Seemueller Florian, Grigoroiu-Serbanescu Maria, Severino Giovanni, Seymour Lisa R., Slaney Claire, Smoller Jordan W., Squassina Alessio, Stamm Thomas, Steele Jo, Stopkova Pavla, Tighe Sarah K., Tortorella Alfonso, Turecki Gustavo, Wray Naomi R., Wright Adam, Zandi Peter P., Zilles David, Bauer Michael, Rietschel Marcella, McMahon Francis J., Schulze Thomas G., Alda Martin

    PLOS ONE   Vol. 8 ( 6 )   2013.6

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    DOI: 10.1371/journal.pone.0065636

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  240. Genome-Wide Association Study of Cognitive Decline in Schizophrenia Reviewed

    Hashimoto Ryota, Ikeda Masashi, Ohi Kazutaka, Yasuda Yuka, Yamamori Hidenaga, Fukumoto Motoyuki, Umeda-Yano Satomi, Dickinson Dwight, Aleksic Branko, Iwase Masao, Kazui Hiroaki, Ozaki Norio, Weinberger Daniel R., Iwata Nakao, Takeda Masatoshi

    AMERICAN JOURNAL OF PSYCHIATRY   Vol. 170 ( 6 ) page: 683-684   2013.6

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    DOI: 10.1176/appi.ajp.2013.12091228

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  241. Effectiveness of low-dose milnacipran for a patient suffering from pain disorder with delusional disorder (somatic type) in the orofacial region Reviewed

    Ukai Katsuyuki, Kimura Hiroyuki, Arao Munetaka, Aleksic Branko, Yamauchi Aya, Ishihara Ryoko, Iritani Shuji, Kurita Kenichi, Ozaki Norio

    PSYCHOGERIATRICS   Vol. 13 ( 2 ) page: 99-102   2013.6

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    DOI: 10.1111/j.1479-8301.2012.00430.x

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  242. Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population Reviewed

    Ikeda M., Aleksic B., Yamada K., Iwayama-Shigeno Y., Matsuo K., Numata S., Watanabe Y., Ohnuma T., Kaneko T., Fukuo Y., Okochi T., Toyota T., Hattori E., Shimodera S., Itakura M., Nunokawa A., Shibata N., Tanaka H., Yoneda H., Arai H., Someya T., Ohmori T., Yoshikawa T., Ozaki N., Iwata N.

    MOLECULAR PSYCHIATRY   Vol. 18 ( 6 ) page: 636-638   2013.6

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    DOI: 10.1038/mp.2012.74

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  243. Genome-wide association study of schizophrenia using microsatellite markers in the Japanese population Reviewed

    Shibata Hiroki, Yamamoto Ken, Sun Zhu, Oka Akira, Inoko Hidetoshi, Arinami Tadao, Inada Toshiya, Ujike Hiroshi, Itokawa Masanari, Tochigi Mamoru, Watanabe Yuichiro, Someya Toshiyuki, Kunugi Hiroshi, Suzuki Tatsuyo, Iwata Nakao, Ozaki Norio, Fukumaki Yasuyuki

    PSYCHIATRIC GENETICS   Vol. 23 ( 3 ) page: 117-123   2013.6

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    DOI: 10.1097/YPG.0b013e32835fe4f1

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  244. Analysis of the VAV3 as Candidate Gene for Schizophrenia: Evidences From Voxel-Based Morphometry and Mutation Screening Reviewed

    Aleksic Branko, Kushima Itaru, Hashimoto Ryota, Ohi Kazutaka, Ikeda Masashi, Yoshimi Akira, Nakamura Yukako, Ito Yoshihito, Okochi Tomo, Fukuo Yasuhisa, Yasuda Yuka, Fukumoto Motoyuki, Yamamori Hidenaga, Ujike Hiroshi, Suzuki Michio, Inada Toshiya, Takeda Masatoshi, Kaibuchi Kozo, Iwata Nakao, Ozaki Norio

    SCHIZOPHRENIA BULLETIN   Vol. 39 ( 3 ) page: 720-728   2013.5

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    DOI: 10.1093/schbul/sbs038

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  245. Effects of repeated dosing with mirtazapine, trazodone, or placebo on driving performance and cognitive function in healthy volunteers Reviewed

    Sasada Kazumi, Iwamoto Kunihiro, Kawano Naoko, Kohmura Kunihiro, Yamamoto Maeri, Aleksic Branko, Ebe Kazutoshi, Noda Yukihiro, Ozaki Norio

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 28 ( 3 ) page: 281-286   2013.5

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    DOI: 10.1002/hup.2321

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  246. Total palliative care for a patient with multiple cerebral infarctions that occurred repeatedly in association with gastric cancer (Trousseau's syndrome) Reviewed

    Ukai Katsuyuki, Okajima Akiko, Yamauchi Aya, Sasaki Eiji, Yamaguchi Yohsuke, Kimura Hiroyuki, Aleksic Branko, Ozaki Norio

    PALLIATIVE & SUPPORTIVE CARE   Vol. 11 ( 2 ) page: 169-172   2013.4

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    DOI: 10.1017/S1478951512000624

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  247. A Population-Specific Uncommon Variant in GRIN3A Associated with Schizophrenia Reviewed

    Takata Atsushi, Iwayama Yoshimi, Fukuo Yasuhisa, Ikeda Masashi, Okochi Tomo, Maekawa Motoko, Toyota Tomoko, Yamada Kazuo, Hattori Eiji, Ohnishi Tetsuo, Toyoshima Manabu, Ujike Hiroshi, Inada Toshiya, Kunugi Hiroshi, Ozaki Norio, Nanko Shinichiro, Nakamura Kazuhiko, Mori Norio, Kanba Shigenobu, Iwata Nakao, Kato Tadafumi, Yoshikawa Takeo

    BIOLOGICAL PSYCHIATRY   Vol. 73 ( 6 ) page: 532-539   2013.3

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    DOI: 10.1016/j.biopsych.2012.10.024

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  248. Effects of sedative antidepressants on prefrontal cortex activity during verbal fluency task in healthy subjects: a near-infrared spectroscopy study Reviewed

    Kohmura Kunihiro, Iwamoto Kunihiro, Aleksic Branko, Sasada Kazumi, Kawano Naoko, Katayama Hiroto, Noda Yukihiro, Noda Akiko, Iidaka Tetsuya, Ozaki Norio

    PSYCHOPHARMACOLOGY   Vol. 226 ( 1 ) page: 75-81   2013.3

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    DOI: 10.1007/s00213-012-2885-8

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  249. DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia Reviewed

    Tanaka S., Syu A., Ishiguro H., Inada T., Horiuchi Y., Ishikawa M., Koga M., Noguchi E., Ozaki N., Someya T., Kakita A., Takahashi H., Nawa H., Arinami T.

    PHARMACOGENOMICS JOURNAL   Vol. 13 ( 1 ) page: 27-34   2013.2

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    DOI: 10.1038/tpj.2011.36

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  250. Adolescent Stress-Induced Epigenetic Control of Dopaminergic Neurons via Glucocorticoids Reviewed

    Niwa Minae, Jaaro-Peled Hanna, Tankou Stephanie, Seshadri Saurav, Hikida Takatoshi, Matsumoto Yurie, Cascella Nicola G., Kano Shin-ichi, Ozaki Norio, Nabeshima Toshitaka, Sawa Akira

    SCIENCE   Vol. 339 ( 6117 ) page: 335-339   2013.1

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    DOI: 10.1126/science.1226931

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  251. Involvement of prostaglandin E2 in behavioral abnormalities induced by neonatal immune activation Reviewed

    Hida Hirotake, Mouri Akihiro, Furuyashiki Tomoyuki, Yamada Kiyofumi, Ozaki Norio, Narumiya Shuh, Nabeshima Toshitaka, Noda Yukihiro

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 121   page: 123P-123P   2013

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  252. Effects of Minocycline on Changes in Brain Tryptophan Metabolism and the Behavior of Juvenile Mice Elicited By Inescapable-Predator Stress.

    Miura H, Ando Y, Noda Y, Ozak N, Isobe K

    J Trauma Stress Disor Treat   Vol. 2 ( 3 )   2013

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    DOI: doi: 10.4172/2324-8947.1000107.

  253. The Postpartum Depressive State in Relation to Perceived Rearing: A Prospective Cohort Study Reviewed

    Hayakawa Norika, Koide Takayoshi, Okada Takashi, Murase Satomi, Aleksic Branko, Furumura Kaori, Shiino Tomoko, Nakamura Yukako, Tamaji Ai, Ishikawa Naoko, Ohoka Harue, Usui Hinako, Banno Naomi, Morita Tokiko, Goto Setsuko, Kanai Atsuko, Masuda Tomoko, Ozaki Norio

    PLOS ONE   Vol. 7 ( 11 )   2012.11

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    DOI: 10.1371/journal.pone.0050220

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  254. Association of Insomnia and Short Sleep Duration With Atherosclerosis Risk in the Elderly Reviewed

    Nakazaki Chie, Noda Akiko, Koike Yasuo, Yamada Sumio, Murohara Toyoaki, Ozaki Norio

    AMERICAN JOURNAL OF HYPERTENSION   Vol. 25 ( 11 ) page: 1149-1155   2012.11

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    DOI: 10.1038/ajh.2012.107

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  255. An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders Reviewed

    Matsunaga Shinji, Ikeda Masashi, Kishi Taro, Fukuo Yasuhisa, Aleksic Branko, Yoshimura Reiji, Okochi Tomo, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Umene-Nakano Wakako, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ujike Hiroshi, Nakamura Jun, Ozaki Norio, Kitajima Tsuyoshi, Iwata Nakao

    NEUROSCIENCE LETTERS   Vol. 529 ( 1 ) page: 66-69   2012.10

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    DOI: 10.1016/j.neulet.2012.08.070

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  256. Myelin-related abnormality of schizophrenia: Genetic, imaging and postmortem study Reviewed

    Ozaki Norio

    ASIA-PACIFIC PSYCHIATRY   Vol. 4   page: 34-34   2012.10

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  257. Involvement of Shati on depression-like behavior in the postpartum period in human and mice Reviewed

    Takaoka K., Uno K., Inagaki R., Nagakura M., Tamaji A., Ozaki N., Miyamoto Y., Nitta A.

    JOURNAL OF NEUROCHEMISTRY   Vol. 123   page: 73-73   2012.10

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  258. What is a rational antidepressant treatment for major depression in patients with Parkinson's disease? Reviewed

    Hagikura Minako, Iwamoto Kunihiro, Aleksic Branko, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 66 ( 5 ) page: 463-463   2012.8

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    DOI: 10.1111/j.1440-1819.2012.02362.x

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  259. Effects of Mild Cognitive Impairment on Driving Performance in Older Drivers Reviewed

    Kawano Naoko, Iwamoto Kunihiro, Iidaka Tetsuya, Ozaki Norio, Suzuki Yusuke, Hasegawa Jun, Umegaki Hiroyuki, Ebe Kazutoshi, Ukai Katsuyuki

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY   Vol. 60 ( 7 ) page: 1379-1381   2012.7

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    DOI: 10.1111/j.1532-5415.2012.04021.x

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  260. The combined measles, mumps, and rubella vaccines and the total number of vaccines are not associated with development of autism spectrum disorder: The first case-control study in Asia Reviewed

    Uno Yota, Uchiyama Tokio, Kurosawa Michiko, Aleksic Branko, Ozaki Norio

    VACCINE   Vol. 30 ( 28 ) page: 4292-4298   2012.6

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    DOI: 10.1016/j.vaccine.2012.01.093

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  261. Slower adaptation to driving simulator and simulator sickness in older adults Reviewed

    Kawano Naoko, Iwamoto Kunihiro, Ebe Kazutoshi, Aleksic Branko, Noda Akiko, Umegaki Hiroyuki, Kuzuya Masafumi, Iidaka Tetsuya, Ozaki Norio

    AGING CLINICAL AND EXPERIMENTAL RESEARCH   Vol. 24 ( 3 ) page: 285-289   2012.6

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  262. Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene-based case-control study and gene expression analysis Reviewed

    Ohi Kazutaka, Hashimoto Ryota, Yasuda Yuka, Fukumoto Motoyuki, Yamamori Hidenaga, Umeda-Yano Satomi, Okada Takeya, Kamino Kouzin, Morihara Takashi, Iwase Masao, Kazui Hiroaki, Numata Shusuke, Ikeda Masashi, Ohnuma Tohru, Iwata Nakao, Ueno Shu-ichi, Ozaki Norio, Ohmori Tetsuro, Arai Heii, Takeda Masatoshi

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 159B ( 4 ) page: 405-413   2012.6

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    DOI: 10.1002/ajmg.b.32043

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  263. No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia Reviewed

    Kitazawa Maiko, Ohnuma Tohru, Takebayashi Yuto, Shibata Nobuto, Baba Hajime, Ohi Kazutaka, Yasuda Yuka, Nakamura Yukako, Aleksic Branko, Yoshimi Akira, Okochi Tomo, Ikeda Masashi, Naitoh Hiroshi, Hashimoto Ryota, Iwata Nakao, Ozaki Norio, Takeda Masatoshi, Arai Heii

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 159B ( 4 ) page: 456-464   2012.6

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    DOI: 10.1002/ajmg.b.32049

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  264. Common Variants in MAGI2 Gene Are Associated with Increased Risk for Cognitive Impairment in Schizophrenic Patients Reviewed

    Koide Takayoshi, Banno Masahiro, Aleksic Branko, Yamashita Saori, Kikuchi Tsutomu, Kohmura Kunihiro, Adachi Yasunori, Kawano Naoko, Kushima Itaru, Nakamura Yukako, Okada Takashi, Ikeda Masashi, Ohi Kazutaka, Yasuda Yuka, Hashimoto Ryota, Inada Toshiya, Ujike Hiroshi, Iidaka Tetsuya, Suzuki Michio, Takeda Masatoshi, Iwata Nakao, Ozaki Norio

    PLOS ONE   Vol. 7 ( 5 )   2012.5

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    DOI: 10.1371/journal.pone.0036836

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  265. A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population Reviewed

    Watanabe Yuichiro, Egawa Jun, Iijima Yoshimi, Nunokawa Ayako, Kaneko Naoshi, Shibuya Masako, Arinami Tadao, Ujike Hiroshi, Inada Toshiya, Iwata Nakao, Tochigi Mamoru, Kunugi Hiroshi, Itokawa Masanari, Ozaki Norio, Hashimoto Ryota, Someya Toshiyuki

    SCHIZOPHRENIA RESEARCH   Vol. 137 ( 1-3 ) page: 264-266   2012.5

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    DOI: 10.1016/j.schres.2012.01.034

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  266. Differential effects of diazepam, tandospirone, and paroxetine on plasma brain-derived neurotrophic factor level under mental stress Reviewed

    Tamaji Ai, Iwamoto Kunihiro, Kawamura Yukiko, Takahashi Masahiro, Ebe Kazutoshi, Kawano Naoko, Kunimoto Shohko, Aleksic Branko, Noda Yukihiro, Ozaki Norio

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 27 ( 3 ) page: 329-333   2012.5

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    DOI: 10.1002/hup.2220

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  267. GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder Reviewed

    Kishi, Taro; Ichinose, Hiroshi; Yoshimura, Reiji; Fukuo, Yasuhisa; Kitajima, Tsuyoshi; Inada, Toshiya; Kunugi, Hiroshi; Kato, Tadafumi; Yoshikawa, Takeo; Ujike, Hiroshi; Musso, Giovanna M.; Umene-Nakano, Wakako; Nakamura, Jun; Ozaki, Norio; Iwata, Nakao

    JOURNAL OF AFFECTIVE DISORDERS   Vol. 142 ( 1-3 ) page: 315-322   2012.5

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    DOI: 10.1016/j.jad.2012.05.004

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  268. Plasma levels of milnacipran and its effectiveness for the treatment of chronic pain in the orofacial region Reviewed

    Kimura Hiroyuki, Yoshida Keizo, Ito Mikiko, Tokura Tatsuya, Nagashima Wataru, Kurita Kenichi, Ozaki Norio

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 27 ( 3 ) page: 322-328   2012.5

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    DOI: 10.1002/hup.2230

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  269. Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility Reviewed

    Kushima Itaru, Nakamura Yukako, Aleksic Branko, Ikeda Masashi, Ito Yoshihito, Shiino Tomoko, Okochi Tomo, Fukuo Yasuhisa, Ujike Hiroshi, Suzuki Michio, Inada Toshiya, Hashimoto Ryota, Takeda Masatoshi, Kaibuchi Kozo, Iwata Nakao, Ozaki Norio

    SCHIZOPHRENIA BULLETIN   Vol. 38 ( 3 ) page: 552-560   2012.5

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    DOI: 10.1093/schbul/sbq118

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  270. Sexual dysfunction and hyperprolactinemia in Japanese schizophrenic patients taking antipsychotics Reviewed

    Kikuchi Tsutomu, Iwamoto Kunihiro, Sasada Kazumi, Aleksic Branko, Yoshida Keizo, Ozaki Norio

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   Vol. 37 ( 1 ) page: 26-32   2012.4

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    DOI: 10.1016/j.pnpbp.2011.11.016

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  271. Prospective Study on the Association between Harm Avoidance and Postpartum Depressive State in a Maternal Cohort of Japanese Women Reviewed

    Furumura Kaori, Koide Takayoshi, Okada Takashi, Murase Satomi, Aleksic Branko, Hayakawa Norika, Shiino Tomoko, Nakamura Yukako, Tamaji Ai, Ishikawa Naoko, Ohoka Harue, Usui Hinako, Banno Naomi, Morita Tokiko, Goto Setsuko, Kanai Atsuko, Masuda Tomoko, Ozaki Norio

    PLOS ONE   Vol. 7 ( 4 )   2012.4

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    DOI: 10.1371/journal.pone.0034725

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  272. Effects of aging on the morphologies of Heschl's gyrus and the superior temporal gyrus in schizophrenia: A postmortem study Reviewed

    Torii Youta, Iritani Shuji, Sekiguchi Hirotaka, Habuchi Chikako, Hagikura Minako, Arai Tetsuaki, Ikeda Kenji, Akiyama Haruhiko, Ozaki Norio

    SCHIZOPHRENIA RESEARCH   Vol. 134 ( 2-3 ) page: 137-142   2012.2

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    DOI: 10.1016/j.schres.2011.10.024

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  273. Serotonin 6 receptor gene and schizophrenia: case-control study and meta-analysis Reviewed

    Kishi Taro, Fukuo Yasuhisa, Okochi Tomo, Kawashima Kunihiro, Kitajima Tsuyoshi, Inada Toshiya, Ozaki Norio, Musso Giovanna M., Kane John M., Correll Christoph U., Iwata Nakao

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 27 ( 1 ) page: 63-69   2012.1

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    DOI: 10.1002/hup.1266

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  274. Association of SNPs linked to increased expression of SLC1A1 with schizophrenia Reviewed

    Horiuchi Yasue, Iida Syuhei, Koga Minori, Ishiguro Hiroki, Iijima Yoshimi, Inada Toshiya, Watanabe Yuichiro, Someya Toshiyuki, Ujike Hiroshi, Iwata Nakao, Ozaki Norio, Kunugi Hiroshi, Tochigi Mamoru, Itokawa Masanari, Arai Makoto, Niizato Kazuhiro, Iritani Shuji, Kakita Akiyoshi, Takahashi Hitoshi, Nawa Hiroyuki, Arinami Tadao

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 159B ( 1 ) page: 30-37   2012.1

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    DOI: 10.1002/ajmg.b.31249

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  275. Wisconsin Card Sorting Test scores and clinical and sociodemographic correlates in Schizophrenia: multiple logistic regression analysis Reviewed

    Banno Masahiro, Koide Takayoshi, Aleksic Branko, Okada Takashi, Kikuchi Tsutomu, Kohmura Kunihiro, Adachi Yasunori, Kawano Naoko, Iidaka Tetsuya, Ozaki Norio

    BMJ OPEN   Vol. 2 ( 6 )   2012

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    DOI: 10.1136/bmjopen-2012-001340

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  276. Blonanserin improves phencyclidine-induced impairment of recognition memory through dopamine D1 receptor Reviewed

    Hida Hirotake, Ogino Yurie, Matsumoto Yurie, Mouri Akihiro, Seki Takeshi, Yamada Kiyofumi, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 118   page: 190P-190P   2012

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  277. CHRONIC SLEEP RESTRICTION IMPAIRED BRAIN TISSUE OXYGENATION IN FRONTAL LOBE Reviewed

    Miyata S., Noda A., Iwamoto K., Ozaki N.

    SLEEP   Vol. 35   page: A107-A107   2012

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  278. Evaluation of factors affecting continuous performance test identical pairs version score of schizophrenic patients in a Japanese clinical sample

    Koide T, Aleksic B, Kikuchi T, Banno M, Kohmura K, Adachi Y, Kawano N, Iidaka T, Ozaki N

    Schizophr Res Treatment   Vol. 2012   page: 2012 970131   2012

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  279. Effectiveness of Duloxetine for the Treatment of Chronic Nonorganic Orofacial Pain Reviewed

    Nagashima Wataru, Kimura Hiroyuki, Ito Mikiko, Tokura Tatsuya, Arao Munetaka, Aleksic Branko, Yoshida Keizo, Kurita Kenichi, Ozaki Norio

    CLINICAL NEUROPHARMACOLOGY   Vol. 35 ( 6 ) page: 273-277   2012

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    DOI: 10.1097/WNF.0b013e31827453fa

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  280. Combination use of Beck Depression Inventory and two-question case-finding instrument as a screening tool for depression in the workplace Reviewed

    Adachi Yasunori, Aleksic Branko, Nobata Ryoko, Suzuki Tatsuyo, Yoshida Keizo, Ono Yuichiro, Ozaki Norio

    BMJ OPEN   Vol. 2 ( 3 )   2012

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    DOI: 10.1136/bmjopen-2011-000596

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  281. CHRONIC SLEEP RESTRICTION INHIBITS BRAIN ACTIVITY MEASURED BY NEAR-INFRARED SPECTROSCOPY Reviewed

    Miyata S., Noda A., Iwamoto K., Ozaki N.

    EUROPEAN PSYCHIATRY   Vol. 27   page: .   2012

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  282. A Case Control Association Study and Cognitive Function Analysis of Neuropilin and Tolloid-Like 1 Gene and Schizophrenia in the Japanese Population Reviewed

    Banno Masahiro, Koide Takayoshi, Aleksic Branko, Yamada Kazuo, Kikuchi Tsutomu, Kohmura Kunihiro, Adachi Yasunori, Kawano Naoko, Kushima Itaru, Ikeda Masashi, Inada Toshiya, Yoshikawa Takeo, Iwata Nakao, Ozaki Norio

    PLOS ONE   Vol. 6 ( 12 )   2011.12

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    DOI: 10.1371/journal.pone.0028929

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  283. Positive Association of Phencyclidine-Responsive Genes, PDE4A and PLAT, With Schizophrenia Reviewed

    Deng Xiangdong, Takaki Hiromi, Wang Lixiang, Kuroki Tosihide, Nakahara Tatsuo, Hashimoto Kijiro, Ninomiya Hideaki, Arinami Tadao, Inada Toshiya, Ujike Hiroshi, Itokawa Masanari, Tochigi Mamoru, Watanabe Yuichiro, Someya Toshiyuki, Kunugi Hiroshi, Iwata Nakao, Ozaki Norio, Shibata Hiroki, Fukumaki Yasuyuki

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 156B ( 7 ) page: 850-858   2011.12

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    DOI: 10.1002/ajmg.b.31233

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  284. Loss of Function Studies in Mice and Genetic Association Link Receptor Protein Tyrosine Phosphatase alpha to Schizophrenia Reviewed

    Takahashi Nagahide, Nielsen Karin Sandager, Aleksic Branko, Petersen Steffen, Ikeda Masashi, Kushima Itaru, Vacaresse Nathalie, Ujike Hiroshi, Iwata Nakao, Dubreuil Veronique, Mirza Naheed, Sakurai Takeshi, Ozaki Norio, Buxbaum Joseph D., Sap Jan

    BIOLOGICAL PSYCHIATRY   Vol. 70 ( 7 ) page: 626-635   2011.10

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    DOI: 10.1016/j.biopsych.2011.06.016

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  285. Prospective study of maternal depressive symptomatology among Japanese women Reviewed

    Ishikawa Naoko, Goto Setsuko, Murase Satomi, Kanai Atsuko, Masuda Tomoko, Aleksic Branko, Usui Hinako, Ozaki Norio

    JOURNAL OF PSYCHOSOMATIC RESEARCH   Vol. 71 ( 4 ) page: 264-269   2011.10

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    DOI: 10.1016/j.jpsychores.2011.02.001

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  286. Maternal mental disorders and pregnancy outcomes: A clinical study in a Japanese population Reviewed

    Hironaka Masae, Kotani Tomomi, Sumigama Seiji, Tsuda Hiroyuki, Mano Yukio, Hayakawa Hiromi, Tanaka Satoshi, Ozaki Norio, Tamakoshi Koji, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 37 ( 10 ) page: 1283-1289   2011.10

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    DOI: 10.1111/j.1447-0756.2010.01512.x

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  287. No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population Reviewed

    Kishi Taro, Fukuo Yasuhisa, Okochi Tomo, Kitajima Tsuyoshi, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Correll Christoph U., Iwata Nakao

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 26 ( 7 ) page: 445-450   2011.10

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    DOI: 10.1002/hup.1223

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  288. Presenile dementia diagnosed as posterior cortical atrophy Reviewed

    Tsunoda Ayami, Iritani Shuji, Ozaki Norio

    PSYCHOGERIATRICS   Vol. 11 ( 3 ) page: 171-176   2011.9

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    DOI: 10.1111/j.1479-8301.2011.00366.x

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  289. Possible association between ubiquitin-specific peptidase 46 gene and major depressive disorders in the Japanese population Reviewed

    Fukuo Yasuhisa, Kishi Taro, Kushima Itaru, Yoshimura Reiji, Okochi Tomo, Kitajima Tsuyoshi, Matsunaga Shinji, Kawashima Kunihiro, Umene-Nakano Wakako, Naitoh Hiroshi, Inada Toshiya, Nakamura Jun, Ozaki Norio, Iwata Nakao

    JOURNAL OF AFFECTIVE DISORDERS   Vol. 133 ( 1-2 ) page: 150-157   2011.9

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    DOI: 10.1016/j.jad.2011.04.020

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  290. DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression Reviewed

    Fuchikami Manabu, Morinobu Shigeru, Segawa Masahiro, Okamoto Yasumasa, Yamawaki Shigeto, Ozaki Norio, Inoue Takeshi, Kusumi Ichiro, Koyama Tsukasa, Tsuchiyama Kounosuke, Terao Takeshi

    PLOS ONE   Vol. 6 ( 8 )   2011.8

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    DOI: 10.1371/journal.pone.0023881

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  291. Lack of association between translin-associated factor X gene (TSNAX) and methamphetamine dependence in the Japanese population Reviewed

    Kishi Taro, Okochi Tomo, Kitajima Tsuyoshi, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Correll Christoph U., Iwata Nakao

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   Vol. 35 ( 7 ) page: 1618-1622   2011.8

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    DOI: 10.1016/j.pnpbp.2011.06.001

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  292. Variants of the RELA Gene are Associated with Schizophrenia and their Startle Responses Reviewed

    Hashimoto Ryota, Ohi Kazutaka, Yasuda Yuka, Fukumoto Motoyuki, Yamamori Hidenaga, Takahashi Hidetoshi, Iwase Masao, Okochi Tomo, Kazui Hiroaki, Saitoh Osamu, Tatsumi Masahiko, Iwata Nakao, Ozaki Norio, Kamijima Kunitoshi, Kunugi Hiroshi, Takeda Masatoshi

    NEUROPSYCHOPHARMACOLOGY   Vol. 36 ( 9 ) page: 1921-1931   2011.8

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    DOI: 10.1038/npp.2011.78

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  293. Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population Reviewed

    Yoshimura Tomoko, Usui Hinako, Takahashi Nagahide, Yoshimi Akira, Saito Shinichi, Aleksic Branko, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Ozaki Norio

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   Vol. 35 ( 5 ) page: 1268-1272   2011.7

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    DOI: 10.1016/j.pnpbp.2011.04.003

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  294. No association between the PCM1 gene and schizophrenia: A multi-center case-control study and a meta-analysis Reviewed

    Hashimoto Ryota, Ohi Kazutaka, Yasuda Yuka, Fukumoto Motoyuki, Yamamori Hidenaga, Kamino Kouzin, Morihara Takashi, Iwase Masao, Kazui Hiroaki, Numata Shusuke, Ikeda Masashi, Ueno Shu-ichi, Ohmori Tetsuro, Iwata Nakao, Ozaki Norio, Takeda Masatoshi

    SCHIZOPHRENIA RESEARCH   Vol. 129 ( 1 ) page: 80-84   2011.6

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    DOI: 10.1016/j.schres.2011.03.024

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  295. Impairment of the tyrosine hydroxylase neuronal network in the orbitofrontal cortex of a genetically modified mouse model of schizophrenia Reviewed

    Sekiguchi Hirotaka, Iritani Shuji, Habuchi Chikako, Torii Yohta, Kuroda Keisuke, Kaibuchi Kozo, Ozaki Norio

    BRAIN RESEARCH   Vol. 1392   page: 47-53   2011.5

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    DOI: 10.1016/j.brainres.2011.03.058

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  296. Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders Reviewed

    Niwa Minae, Matsumoto Yurie, Mouri Akihiro, Ozaki Norio, Nabeshima Toshitaka

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   Vol. 14 ( 4 ) page: 459-477   2011.5

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    DOI: 10.1017/S1461145710001239

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  297. Long-lasting effects of inescapable-predator stress on brain tryptophan metabolism and the behavior of juvenile mice Reviewed

    Miura Hideki, Ando Yu, Noda Yukihiro, Isobe Kenichi, Ozaki Norio

    STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS   Vol. 14 ( 3 ) page: 262-272   2011.5

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    DOI: 10.3109/10253890.2010.541539

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  298. SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study Reviewed

    Kishi T., Fukuo Y., Kitajima T., Okochi T., Yamanouchi Y., Kinoshita Y., Kawashima K., Inada T., Kunugi H., Kato T., Yoshikawa T., Ujike H., Ozaki N., Iwata N.

    GENES BRAIN AND BEHAVIOR   Vol. 10 ( 3 ) page: 257-263   2011.4

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    DOI: 10.1111/j.1601-183X.2010.00661.x

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  299. Association of ANK3 With Bipolar Disorder Confirmed in East Asia Reviewed

    Takata Atsushi, Kim Se Hyun, Ozaki Norio, Iwata Nakao, Kunugi Hiroshi, Inada Toshiya, Ujike Hiroshi, Nakamura Kazuhiko, Mori Norio, Ahn Yong Min, Joo Eun-Jeong, Song Joo Yun, Kanba Shigenobu, Yoshikawa Takeo, Kim Yong Sik, Kato Tadafumi

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 156B ( 3 ) page: 312-315   2011.4

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    DOI: 10.1002/ajmg.b.31164

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  300. Genome-Wide Association Study of Schizophrenia in a Japanese Population Reviewed

    Ikeda Masashi, Aleksic Branko, Kinoshita Yoko, Okochi Tomo, Kawashima Kunihiro, Kushima Itaru, Ito Yoshihito, Nakamura Yukako, Kishi Taro, Okumura Takenori, Fukuo Yasuhisa, Williams Hywel J., Hamshere Marian L., Ivanov Dobril, Inada Toshiya, Suzuki Michio, Hashimoto Ryota, Ujike Hiroshi, Takeda Masatoshi, Craddock Nick, Kaibuchi Kozo, Owen Michael J., Ozaki Norio, O'Donovan Michael C., Iwata Nakao

    BIOLOGICAL PSYCHIATRY   Vol. 69 ( 5 ) page: 472-478   2011.3

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    DOI: 10.1016/j.biopsych.2010.07.010

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  301. Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence Reviewed

    Kishi Taro, Kitajima Tsuyoshi, Kawashima Kunihiro, Okochi Tomo, Yamanouchi Yoshio, Kinoshita Yoko, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

    CURRENT NEUROPHARMACOLOGY   Vol. 9 ( 1 ) page: 129-132   2011.3

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  302. Association Study of Serine Racemase Gene with Methamphetamine Psychosis Reviewed

    Yokobayashi E., Ujike H., Kotaka T., Okahisa Y., Takaki M., Kodama M., Inada T., Uchimura N., Yamada M., Iwata N., Iyo M., Sora I., Ozaki N., Kuroda S.

    CURRENT NEUROPHARMACOLOGY   Vol. 9 ( 1 ) page: 169-175   2011.3

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  303. Association Study of Two Cannabinoid Receptor Genes, CNR1 and CNR2, with Methamphetamine Dependence Reviewed

    Okahisa Y., Kodama M., Takaki M., Inada T., Uchimura N., Yamada M., Iwata N., Iyo M., Sora I., Ozaki N., Ujike H.

    CURRENT NEUROPHARMACOLOGY   Vol. 9 ( 1 ) page: 183-189   2011.3

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  304. Association between the Regulator of G-protein Signaling 9 Gene and Patients with Methamphetamine Use Disorder and Schizophrenia Reviewed

    Okahisa Y., Kodama M., Takaki M., Inada T., Uchimura N., Yamada M., Iwata N., Iyo M., Sora I., Ozaki N., Ujike H.

    CURRENT NEUROPHARMACOLOGY   Vol. 9 ( 1 ) page: 190-194   2011.3

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  305. Association Between 5HT1b Receptor Gene and Methamphetamine Dependence Reviewed

    Ujike H., Kishimoto M., Okahisa Y., Kodama M., Takaki M., Inada T., Uchimura N., Yamada M., Iwata N., Iyo M., Sora I., Ozaki N.

    CURRENT NEUROPHARMACOLOGY   Vol. 9 ( 1 ) page: 163-168   2011.3

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  306. Association Analysis of the Tryptophan Hydroxylase 2 Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis Reviewed

    Kobayashi Hideaki, Ujike Hiroshi, Iwata Nakao, Inada Toshiya, Yamada Mitsuhiko, Sekine Yoshimoto, Uchimura Naohisa, Iyo Masaomi, Ozaki Norio, Itokawa Masanari, Sora Ichiro

    CURRENT NEUROPHARMACOLOGY   Vol. 9 ( 1 ) page: 176-182   2011.3

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  307. Association Analysis of the Adenosine A1 Receptor Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis Reviewed

    Kobayashi Hideaki, Ujike Hiroshi, Iwata Nakao, Inada Toshiya, Yamada Mitsuhiko, Sekine Yoshimoto, Uchimura Naohisa, Iyo Masaomi, Ozaki Norio, Itokawa Masanari, Sora Ichiro

    CURRENT NEUROPHARMACOLOGY   Vol. 9 ( 1 ) page: 137-142   2011.3

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  308. Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese Reviewed

    Okumura Takenori, Okochi Tomo, Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Kinoshita Yoko, Kawashima Kunihiro, Tsunoka Tomoko, Fukuo Yasuhisa, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Ujike Hiroshi, Iwata Nakao

    CURRENT NEUROPHARMACOLOGY   Vol. 9 ( 1 ) page: 155-159   2011.3

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  309. Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese Reviewed

    Okochi T., Kishi T., Ikeda M., Kitajima T., Kinoshita Y., Kawashima K., Okumura T., Tsunoka T., Fukuo Y., Inada T., Yamada M., Uchimura N., Iyo M., Sora I., Ozaki N., Ujike H., Iwata N.

    CURRENT NEUROPHARMACOLOGY   Vol. 9 ( 1 ) page: 151-154   2011.3

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  310. Lack of Association Between Prokineticin 2 Gene and Japanese Methamphetamine Dependence Reviewed

    Kishi Taro, Kitajima Tsuyoshi, Tsunoka Tomoko, Okumura Takenori, Kawashima Kunihiro, Okochi Tomo, Yamanouchi Yoshio, Kinoshita Yoko, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

    CURRENT NEUROPHARMACOLOGY   Vol. 9 ( 1 ) page: 133-136   2011.3

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  311. No Association Between GRM3 and Japanese Methamphetamine-Induced Psychosis Reviewed

    Tsunoka Tomoko, Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Inada Toshiya, Ujike Hiroshi, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

    CURRENT NEUROPHARMACOLOGY   Vol. 9 ( 1 ) page: 160-162   2011.3

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  312. Clinicopathological study of diffuse neurofibrillary tangles with calcification With special reference to TDP-43 proteinopathy and alpha-synucleinopathy Reviewed

    Habuchi Chikako, Iritani Shuji, Sekiguchi Hirotaka, Torii Youta, Ishihara Ryoko, Arai Tetsuaki, Hasegawa Masato, Tsuchiya Kuniaki, Akiyama Haruhiko, Shibayama Hiroto, Ozaki Norio

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 301 ( 1-2 ) page: 77-85   2011.2

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    DOI: 10.1016/j.jns.2010.10.021

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  313. Serotonin 1A receptor gene, schizophrenia and bipolar disorder: An association study and meta-analysis Reviewed

    Kishi Taro, Okochi Tomo, Tsunoka Tomoko, Okumura Takenori, Kitajima Tsuyoshi, Kawashima Kunihiro, Yamanouchi Yoshio, Kinoshita Yoko, Naitoh Hiroshi, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ujike Hiroshi, Ozaki Norio, Iwata Nakao

    PSYCHIATRY RESEARCH   Vol. 185 ( 1-2 ) page: 20-26   2011.1

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    DOI: 10.1016/j.psychres.2010.06.003

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  314. Serotonin 6 receptor gene is associated with methamphetamine-induced psychosis in a Japanese population Reviewed

    Kishi Taro, Fukuo Yasuhisa, Okochi Tomo, Kitajima Tsuyoshi, Kawashima Kunihiro, Naitoh Hiroshi, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

    DRUG AND ALCOHOL DEPENDENCE   Vol. 113 ( 1 ) page: 1-7   2011.1

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    DOI: 10.1016/j.drugalcdep.2010.06.021

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  315. Depression associated with alcohol intake and younger age in Japanese office workers: A case-control and a cohort study Reviewed

    Ogasawara Kazuyoshi, Nakamura Yukako, Aleksic Branko, Yoshida Keizo, Ando Katsuhisa, Iwata Nakao, Kayukawa Yuhei, Ozaki Norio

    JOURNAL OF AFFECTIVE DISORDERS   Vol. 128 ( 1-2 ) page: 33-40   2011.1

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    DOI: 10.1016/j.jad.2010.06.015

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  316. The effects of mild cognitive impairment on driving performance in elderly drivers Reviewed

    Kawano Naoko, Iwamoto Kunihiro, Sasada Kazumi, Kohmura Kunihiro, Yamamoto Maeri, Ebe Kazutoshi, Iidaka Tetsuya, Ozaki Norio

    NEUROSCIENCE RESEARCH   Vol. 71   page: E389-E389   2011

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    DOI: 10.1016/j.neures.2011.07.1706

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  317. Necessity for ethical consideration of research in the aftermath of disaster Reviewed

    Iijima Yoshihiko, Aleksic Branko, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 65 ( 5 ) page: 535-536   2011

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    DOI: 10.1111/j.1440-1819.2011.02238.x

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  318. ONE NIGHT SLEEP RESTRICTION IMPAIRS THE CORTICAL OXYGENATION RESPONSES Reviewed

    Miyata S., Noda A., Ito M., Iwamoto K., Ozaki N.

    EUROPEAN PSYCHIATRY   Vol. 26   page: .   2011

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  319. Reliability and validity of a new sexual function questionnaire (Nagoya Sexual Function Questionnaire) for schizophrenic patients taking antipsychotics Reviewed

    Kikuchi Tsutomu, Iwamoto Kunihiro, Sasada Kazumi, Aleksic Branko, Yoshida Keizo, Ozaki Norio

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 26 ( 4-5 ) page: 300-306   2011

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    DOI: 10.1002/hup.1205

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  320. Proteomic analyses for identifying causative factors of schizophrenia and bipolar disorder Reviewed

    Ohashi Mitsuki, Yamada Shinnnosuke, Yoshimi Akira, Ishihara Ryoko, Nagai Taku, Yamada Kiyofumi, Noda Yukihiro, Ozaki Norio

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 115   page: 142P-142P   2011

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  321. Protein tyrosine phosphatase alpha as novel candidate molecule for the etiopathology of schizophrenia: Genetic analysis and biological implications Reviewed

    Ozaki Norio

    NEUROSCIENCE RESEARCH   Vol. 71   page: E27-E27   2011

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    DOI: 10.1016/j.neures.2011.07.116

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  322. Social defeat stress during juvenile stage impaired social behaviors associated with alternation of brain monoaminergic functions Reviewed

    Ando Yu, Mouri Akihiro, Hida Hirotake, Waki Yukari, Yoshimi Akira, Nabeshima Toshitaka, Ozaki Norio, Noda Yukihiro

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 115   page: 250P-250P   2011

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  323. The CLOCK Gene and Mood Disorders: A Case-Control Study and Meta-analysis Reviewed

    Kishi Taro, Yoshimura Reiji, Fukuo Yasuhisa, Kitajima Tsuyoshi, Okochi Tomo, Matsunaga Shinji, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ujike Hiroshi, Umene-Nakano Wakako, Nakamura Jun, Ozaki Norio, Serretti Alessandro, Correll Christoph U., Iwata Nakao

    CHRONOBIOLOGY INTERNATIONAL   Vol. 28 ( 9 ) page: 825-833   2011

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    DOI: 10.3109/07420528.2011.609951

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  324. Variants of the RELA gene are associated with schizophrenia and prepulse inhibition Reviewed

    Hashimoto Ryota, Ohi Kazutaka, Yasuda Yuka, Fukumoto Motoyuki, Yamamori Hidenaga, Takahashi Hidetoshi, Iwase Masao, Okochi Tomo, Kazui Hiroaki, Saitoh Osamu, Tatsumi Masahiko, Iwata Nakao, Ozaki Norio, Kamijima Kunitoshi, Kunugi Hiroshi, Takeda Masatoshi

    NEUROSCIENCE RESEARCH   Vol. 71   page: E395-E395   2011

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    DOI: 10.1016/j.neures.2011.07.1733

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  325. "Rework Program" in Japan: Innovative high-level rehabilitation Reviewed

    Akiyama Tsuyoshi, Tsuchiya Masao, Igarashi Yoshio, Ozaki Norio, Yokoyama Motonori, Katagiri Yoko, Tajima Miyuki, Matsunaga Miki, Kitagawa Nobuki, Nakamoto Haruo, Ohno Yutaka, Bernick Peter

    ASIA-PACIFIC PSYCHIATRY   Vol. 2 ( 4 ) page: 208-216   2010.12

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    DOI: 10.1111/j.1758-5872.2010.00093.x

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  326. Gene-wide association study between the methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population, with an updated meta-analysis on currently available data Reviewed

    Yoshimi Akira, Aleksic Branko, Kawamura Yukiko, Takahashi Nagahide, Yamada Shinnosuke, Usui Hinako, Saito Shinichi, Ito Yoshihito, Iwata Nakao, Inada Toshiya, Noda Yukihiro, Yamada Kiyofumi, Ozaki Norio

    SCHIZOPHRENIA RESEARCH   Vol. 124 ( 1-3 ) page: 216-222   2010.12

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    DOI: 10.1016/j.schres.2010.07.011

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  327. Influence of HTR2A polymorphisms and parental rearing on personality traits in healthy Japanese subjects Reviewed

    Nakamura Yukako, Ito Yoshihito, Aleksic Branko, Kushima Itaru, Yasui-Furukori Norio, Inada Toshiya, Ono Yutaka, Ozaki Norio

    JOURNAL OF HUMAN GENETICS   Vol. 55 ( 12 ) page: 838-841   2010.12

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    DOI: 10.1038/jhg.2010.110

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  328. Immunohistochemical Study of Vesicle Monoamine Transporter 2 in the Hippocampal Region of Genetic Animal Model of Schizophrenia Reviewed

    Iritani Shuji, Sekiguchi Hirotaka, Habuchi Chikako, Hikita Takao, Taya Shinichiro, Kaibuchi Kozo, Ozaki Norio

    SYNAPSE   Vol. 64 ( 12 ) page: 948-953   2010.12

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    DOI: 10.1002/syn.20846

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  329. A case of dementia with Lewy bodies that temporarily showed symptoms similar to Creutzfeldt-Jakob disease Reviewed

    Ukai Katsuyuki, Matsuo Koji, Nakamura Ryoichi, Sobue Gen, Kosaka Kenji, Shibayama Hiroto, Iritani Shuji, Ishihara Ryoko, Ozaki Norio

    PSYCHOGERIATRICS   Vol. 10 ( 4 ) page: 201-205   2010.12

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    DOI: 10.1111/j.1479-8301.2010.00336.x

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  330. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems Reviewed

    Noda Yukihiro, Mouri Akihiro, Ando Yu, Waki Yukari, Yamada Shin-Nosuke, Yoshimi Akira, Yamada Kiyofumi, Ozaki Norio, Wang Dayong, Nabeshima Toshitaka

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   Vol. 13 ( 10 ) page: 1343-1354   2010.11

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    DOI: 10.1017/S1461145710000222

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  331. SIRT1 gene is associated with major depressive disorder in the Japanese population Reviewed

    Kishi Taro, Yoshimura Reiji, Kitajima Tsuyoshi, Okochi Tomo, Okumura Takenori, Tsunoka Tomoko, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Fukuo Yasuhisa, Naitoh Hiroshi, Umene-Nakano Wakako, Inada Toshiya, Nakamura Jun, Ozaki Norio, Iwata Nakao

    JOURNAL OF AFFECTIVE DISORDERS   Vol. 126 ( 1-2 ) page: 167-173   2010.10

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    DOI: 10.1016/j.jad.2010.04.003

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  332. Immunohistochemical study of vesicle monoamine transporter 2 in the hippocampal formation of PCP-treated mice Reviewed

    Iritani Shuji, Sekiguchi Hirotaka, Habuchi Chikako, Torii Youta, Yamada Shinnosuke, Waki Yukari, Noda Yukihiro, Furukawa Hiroshi, Nabeshima Toshitaka, Ozaki Norio

    NEUROSCIENCE RESEARCH   Vol. 68 ( 2 ) page: 125-130   2010.10

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    DOI: 10.1016/j.neures.2010.06.005

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  333. An association study between the dymeclin gene and schizophrenia in the Japanese population Reviewed

    Yazaki Saori, Koga Minori, Ishiguro Hiroki, Inada Toshiya, Ujike Hiroshi, Itokawa Masanari, Otowa Takeshi, Watanabe Yuichiro, Someya Toshiyuki, Iwata Nakao, Kunugi Hiroshi, Ozaki Norio, Arinami Tadao

    JOURNAL OF HUMAN GENETICS   Vol. 55 ( 9 ) page: 631-634   2010.9

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    DOI: 10.1038/jhg.2010.72

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  334. HTR2A is Associated with SSRI Response in Major Depressive Disorder in a Japanese Cohort Reviewed

    Kishi Taro, Yoshimura Reiji, Kitajima Tsuyoshi, Okochi Tomo, Okumura Takenori, Tsunoka Tomoko, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Naitoh Hiroshi, Nakamura Jun, Ozaki Norio, Iwata Nakao

    NEUROMOLECULAR MEDICINE   Vol. 12 ( 3 ) page: 237-242   2010.9

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    DOI: 10.1007/s12017-009-8105-y

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  335. Lack of Association Between MAGEL2 and Schizophrenia and Mood Disorders in the Japanese Population Reviewed

    Fukuo Yasuhisa, Kishi Taro, Okochi Tomo, Kitajima Tsuyoshi, Tsunoka Tomoko, Okumukura Takenori, Kinoshita Yoko, Kawashima Kunihiro, Yamanouchi Yoshio, Umene-Nakano Wakako, Naitoh Hiroshi, Inada Toshiya, Yoshimura Reiji, Nakamura Jun, Ozaki Norio, Iwata Nakao

    NEUROMOLECULAR MEDICINE   Vol. 12 ( 3 ) page: 285-291   2010.9

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    DOI: 10.1007/s12017-010-8116-8

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  336. Transient Neural Activation in Human Amygdala Involved in Aversive Conditioning of Face and Voice Reviewed

    Iidaka Tetsuya, Saito Daisuke N., Komeda Hidetsugu, Mano Yoko, Kanayama Noriaki, Osumi Takahiro, Ozaki Norio, Sadato Norihiro

    JOURNAL OF COGNITIVE NEUROSCIENCE   Vol. 22 ( 9 ) page: 2074-2085   2010.9

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  337. The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population Reviewed

    Kobayashi Hideaki, Ujike Hiroshi, Iwata Nakao, Inada Toshiya, Yamada Mitsuhiko, Sekine Yoshimoto, Uchimura Naohisa, Iyo Masaomi, Ozaki Norio, Itokawa Masanari, Sora Ichiro

    BEHAVIORAL AND BRAIN FUNCTIONS   Vol. 6   2010.8

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    DOI: 10.1186/1744-9081-6-50

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  338. PROKR2 is associated with methamphetamine dependence in the Japanese population Reviewed

    Kishi Taro, Kitajima Tsuyoshi, Tsunoka Tomoko, Okumura Takenori, Okochi Tomo, Kawashima Kunihiro, Inada Toshiya, Ujike Hiroshi, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   Vol. 34 ( 6 ) page: 1033-1036   2010.8

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    DOI: 10.1016/j.pnpbp.2010.05.018

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  339. Pharmacogenetic study of serotonin 6 receptor gene with antidepressant response in major depressive disorder in the Japanese population Reviewed

    Kishi Taro, Fukuo Yasuhisa, Yoshimura Reiji, Okochi Tomo, Kitajima Tsuyoshi, Naitoh Hiroshi, Umene-Nakano Wakako, Nakamura Jun, Ozaki Norio, Iwata Nakao

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 25 ( 6 ) page: 481-486   2010.8

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    DOI: 10.1002/hup.1142

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  340. Supportive Evidence for Reduced Expression of GNB1L in Schizophrenia Reviewed

    Ishiguro Hiroki, Koga Minori, Horiuchi Yasue, Noguchi Emiko, Morikawa Miyuki, Suzuki Yoshimi, Arai Makoto, Niizato Kazuhiro, Iritani Shyuji, Itokawa Masanari, Inada Toshiya, Iwata Nakao, Ozaki Norio, Ujike Hiroshi, Kunugi Hiroshi, Sasaki Tsukasa, Takahashi Makoto, Watanabe Yuichiro, Someya Toshiyuki, Kakita Akiyoshi, Takahashi Hitoshi, Nawa Hiroyuki, Arinami Tadao

    SCHIZOPHRENIA BULLETIN   Vol. 36 ( 4 ) page: 756-765   2010.7

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    DOI: 10.1093/schbul/sbn160

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  341. Serotonin 6 receptor gene and mood disorders: Case-control study and meta-analysis Reviewed

    Fukuo Yasuhisa, Kishi Taro, Yoshimura Reiji, Kitajima Tsuyoshi, Okochi Tomo, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Naitoh Hiroshi, Umene-Nakano Wakako, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ujike Hiroshi, Nakamura Jun, Ozaki Norio, Iwata Nakao

    NEUROSCIENCE RESEARCH   Vol. 67 ( 3 ) page: 250-255   2010.7

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    DOI: 10.1016/j.neures.2010.04.003

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  342. White matter microstructure of the cingulum and cerebellar peduncle is related to sustained attention and working memory: A diffusion tensor imaging study Reviewed

    Takahashi Masahiro, Iwamoto Kunihiro, Fukatsu Hiroshi, Naganawa Shinji, Iidaka Tetsuya, Ozaki Norio

    NEUROSCIENCE LETTERS   Vol. 477 ( 2 ) page: 72-76   2010.6

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    DOI: 10.1016/j.neulet.2010.04.031

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  343. Association analysis of SIGMAR1 with major depressive disorder and SSRI response Reviewed

    Kishi Taro, Yoshimura Reiji, Okochi Tomo, Fukuo Yasuhisa, Kitajima Tsuyoshi, Okumura Takenori, Tsunoka Tomoko, Kawashima Kunihiro, Yamanouchi Yoshio, Kinoshita Yoko, Umene-Nakano Wakako, Naitoh Hiroshi, Nakamura Jun, Ozaki Norio, Iwata Nakao

    NEUROPHARMACOLOGY   Vol. 58 ( 7 ) page: 1168-1173   2010.6

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    DOI: 10.1016/j.neuropharm.2010.02.013

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  344. Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures Reviewed

    Takahashi Makoto, Hayashi Hiroshi, Watanabe Yuichiro, Sawamura Kazushi, Fukui Naoki, Watanabe Junzo, Kitajima Tsuyoshi, Yamanouchi Yoshio, Iwata Nakao, Mizukami Katsuyoshi, Hori Takafumi, Shimoda Kazutaka, Ujike Hiroshi, Ozaki Norio, Iijima Kentarou, Takemura Kazuo, Aoshima Hideyuki, Someya Toshiyuki

    SCHIZOPHRENIA RESEARCH   Vol. 119 ( 1-3 ) page: 210-218   2010.6

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    DOI: 10.1016/j.schres.2009.12.024

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  345. Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population Reviewed

    Tsunoka Tomoko, Kishi Taro, Kitajima Tsuyoshi, Okochi Tomo, Okumura Takenori, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Naitoh Hiroshi, Inada Toshiya, Ujike Hiroshi, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   Vol. 34 ( 4 ) page: 639-644   2010.5

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    DOI: 10.1016/j.pnpbp.2010.03.002

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  346. Brain Cannabinoid CB2 Receptor in Schizophrenia Reviewed

    Ishiguro Hiroki, Horiuchi Yasue, Ishikawa Maya, Koga Minori, Imai Keiko, Suzuki Yoshimi, Morikawa Miyuki, Inada Toshiya, Watanabe Yuichiro, Takahashi Makoto, Someya Toshiyuki, Ujike Hiroshi, Iwata Nakao, Ozaki Norio, Onaivi Emmanuel S., Kunugi Hiroshi, Sasaki Tsukasa, Itokawa Masanari, Arai Makoto, Niizato Kazuhiro, Iritani Shyuji, Naka Izumi, Ohashi Jun, Kakita Akiyoshi, Takahashi Hitoshi, Nawa Hiroyuki, Arinami Tadao

    BIOLOGICAL PSYCHIATRY   Vol. 67 ( 10 ) page: 974-982   2010.5

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    DOI: 10.1016/j.biopsych.2009.09.024

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  347. No association between DAO and schizophrenia in a Japanese patient population: A multicenter replication study Reviewed

    Ohnuma Tohru, Shibata Nobuto, Baba Hajime, Ohi Kazutaka, Yasuda Yuka, Nakamura Yukako, Okochi Tomo, Naitoh Hiroshi, Hashimoto Ryota, Iwata Nakao, Ozaki Norio, Takeda Masatoshi, Arai Heii

    SCHIZOPHRENIA RESEARCH   Vol. 118 ( 1-3 ) page: 300-302   2010.5

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    DOI: 10.1016/j.schres.2010.01.028

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  348. Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: A three-stage case-control association study Reviewed

    Amagane Hideki, Watanabe Yuichiro, Kaneko Naoshi, Nunokawa Ayako, Muratake Tatsuyuki, Ishiguro Hiroki, Arinami Tadao, Ujike Hiroshi, Inada Toshiya, Iwata Nakao, Kunugi Hiroshi, Sasaki Tsukasa, Hashimoto Ryota, Itokawa Masanari, Ozaki Norio, Someya Toshiyuki

    SCHIZOPHRENIA RESEARCH   Vol. 118 ( 1-3 ) page: 106-112   2010.5

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    DOI: 10.1016/j.schres.2010.01.023

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  349. Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population Reviewed

    Aleksic Branko, Kushima Itaru, Ito Yoshihito, Nakamura Yukako, Ujike Hiroshi, Suzuki Michio, Inada Toshiya, Hashimoto Ryota, Takeda Masatoshi, Iwata Nakao, Ozaki Norio

    SCHIZOPHRENIA RESEARCH   Vol. 118 ( 1-3 ) page: 113-117   2010.5

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    DOI: 10.1016/j.schres.2010.01.014

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  350. The effects of acute treatment with tandospirone, diazepam, and placebo on driving performance and cognitive function in healthy volunteers Reviewed

    Takahashi Masahiro, Iwamoto Kunihiro, Kawamura Yukiko, Nakamura Yukako, Ishihara Ryoko, Uchiyama Yuji, Ebe Kazutoshi, Noda Akiko, Noda Yukihiro, Yoshida Keizo, Iidaka Tetsuya, Ozaki Norio

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 25 ( 3 ) page: 260-267   2010.4

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    DOI: 10.1002/hup.1105

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  351. Association of the HSPG2 Gene with Neuroleptic-Induced Tardive Dyskinesia Reviewed

    Syu Aoi, Ishiguro Hiroki, Inada Toshiya, Horiuchi Yasue, Tanaka Syunsuke, Ishikawa Maya, Arai Makoto, Itokawa Masanari, Niizato Kazuhiro, Iritani Shuji, Ozaki Norio, Takahashi Makoto, Kakita Akiyoshi, Takahashi Hitoshi, Nawa Hiroyuki, Keino-Masu Kazuko, Arikawa-Hirasawa Eri, Arinami Tadao

    NEUROPSYCHOPHARMACOLOGY   Vol. 35 ( 5 ) page: 1155-1164   2010.4

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    DOI: 10.1038/npp.2009.220

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  352. Association Study of Bromodomain-Containing 1 Gene With Schizophrenia in Japanese Population Reviewed

    Kushima Itaru, Aleksic Branko, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Ito Yoshihito, Nakamura Yukako, Inada Toshiya, Iwata Nakao, Ozaki Norio

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 153B ( 3 ) page: 786-791   2010.4

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    DOI: 10.1002/ajmg.b.31048

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  353. A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls Reviewed

    Hashimoto Ryota, Noguchi Hiroko, Hori Hiroaki, Nakabayashi Tetsuo, Suzuki Tatsuyo, Iwata Nakao, Ozaki Norio, Kosuga Asako, Tatsumi Masahiko, Kamijima Kunitoshi, Harada Seiichi, Takeda Masatoshi, Saitoh Osamu, Kunugi Hiroshi

    WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY   Vol. 11 ( 2 ) page: 431-438   2010.3

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    DOI: 10.3109/15622970902736503

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  354. Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population Reviewed

    Kushima Itaru, Aleksic Branko, Ito Yoshihito, Nakamura Yukako, Nakamura Kazuhiko, Mori Norio, Kikuchi Mitsuru, Inada Toshiya, Kunugi Hiroshi, Nanko Shinichiro, Kato Tadafumi, Yoshikawa Takeo, Ujike Hiroshi, Suzuki Michio, Iwata Nakao, Ozaki Norio

    JOURNAL OF HUMAN GENETICS   Vol. 55 ( 3 ) page: 133-136   2010.3

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    DOI: 10.1038/jhg.2009.139

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  355. Translin-Associated Factor X Gene (TSNAX) may be Associated with Female major Depressive Disorder in the Japanese Population Reviewed

    Okuda Akiko, Kishi Taro, Okochi Tomo, Ikeda Masashi, Kitajima Tsuyoshi, Tsunoka Tomoko, Okumukura Takenori, Fukuo Yasuhisa, Kinoshita Yoko, Kawashima Kunihiro, Yamanouchi Yoshio, Inada Toshiya, Ozaki Norio, Iwata Nakao

    NEUROMOLECULAR MEDICINE   Vol. 12 ( 1 ) page: 78-85   2010.3

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    DOI: 10.1007/s12017-009-8090-1

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  356. Association Analyses Between Brain-Expressed Fatty-Acid Binding Protein (FABP) Genes and Schizophrenia and Bipolar Disorder Reviewed

    Iwayama Yoshimi, Hattori Eiji, Maekawa Motoko, Yamada Kazuo, Toyota Tomoko, Ohnishi Tetsuo, Iwata Yasuhide, Tsuchiya Kenji J., Sugihara Genichi, Kikuchi Mitsuru, Hashimoto Kenji, Iyo Masaomi, Inada Toshiya, Kunugi Hiroshi, Ozaki Norio, Iwata Nakao, Nanko Shinichiro, Iwamoto Kazuya, Okazaki Yuji, Kato Tadafumi, Yoshikawa Takeo

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 153B ( 2 ) page: 484-493   2010.3

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    DOI: 10.1002/ajmg.b.31004

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  357. Identification of Novel Candidate Genes for Treatment Response to Risperidone and Susceptibility for Schizophrenia: Integrated Analysis Among Pharmacogenomics, Mouse Expression, and Genetic Case-Control Association Approaches Masashi Ikeda Reviewed

    Ikeda Masashi, Tomita Yasuyuki, Mouri Akihiro, Koga Minori, Okochi Tomo, Yoshimura Reiji, Yamanouchi Yoshio, Kinoshita Yoko, Hashimoto Ryota, Williams Hywel J., Takeda Masatoshi, Nakamura Jun, Nabeshima Toshitaka, Owen Michael J., O'Donovan Michael C., Honda Hiroyuki, Arinami Tadao, Ozaki Norio, Iwata Nakao

    BIOLOGICAL PSYCHIATRY   Vol. 67 ( 3 ) page: 263-269   2010.2

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    DOI: 10.1016/j.biopsych.2009.08.030

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  358. Copy Number Variation in Schizophrenia in the Japanese Population Reviewed

    Ikeda Masashi, Aleksic Branko, Kirov George, Kinoshita Yoko, Yamanouchi Yoshio, Kitajima Tsuyoshi, Kawashima Kunihiro, Okochi Tomo, Kishi Taro, Zaharieva Irina, Owen Michael J., O'Donovan Michael C., Ozaki Norio, Iwata Nakao

    BIOLOGICAL PSYCHIATRY   Vol. 67 ( 3 ) page: 283-286   2010.2

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    DOI: 10.1016/j.biopsych.2009.08.034

    Web of Science

  359. The chitinase 3-like 1 gene and schizophrenia: Evidence from a multi-center case-control study and meta-analysis Reviewed

    Ohi Kazutaka, Hashimoto Ryota, Yasuda Yuka, Yoshida Tetsuhiko, Takahashi Hidetoshi, Iike Naomi, Iwase Masao, Kamino Kouzin, Ishii Ryouhei, Kazui Hiroaki, Fukumoto Motoyuki, Takamura Hironori, Yamamori Hidenaga, Azechi Michiyo, Ikezawa Koji, Tanimukai Hitoshi, Tagami Shinji, Morihara Takashi, Okochi Masayasu, Yamada Kazuo, Numata Shusuke, Ikeda Masashi, Tanaka Toshihisa, Kudo Takashi, Ueno Shu-ichi, Yoshikawa Takeo, Ohmori Tetsuro, Iwata Nakao, Ozaki Norio, Takeda Masatoshi

    SCHIZOPHRENIA RESEARCH   Vol. 116 ( 2-3 ) page: 126-132   2010.2

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    DOI: 10.1016/j.schres.2009.12.002

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  360. Measurement limit of quality-of-life questionnaires in psychiatric settings Reviewed

    Nishiyama Takeshi, Ozaki Norio

    QUALITY OF LIFE RESEARCH   Vol. 19 ( 1 ) page: 25-30   2010.2

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    DOI: 10.1007/s11136-009-9556-1

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  361. Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients Reviewed

    Kishi Taro, Tsunoka Tomoko, Ikeda Masashi, Kitajima Tsuyoshi, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Yamanouchi Yoshio, Kinoshita Yoko, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

    NEUROPHARMACOLOGY   Vol. 58 ( 2 ) page: 452-456   2010.2

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    DOI: 10.1016/j.neuropharm.2009.09.006

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  362. Insufficient sleep impairs driving performance and cognitive function Reviewed

    Miyata Seiko, Noda Akiko, Ozaki Norio, Hara Yuki, Minoshima Makoto, Iwamoto Kunihiro, Takahashi Masahiro, Iidaka Tetsuya, Koike Yasuo

    NEUROSCIENCE LETTERS   Vol. 469 ( 2 ) page: 229-233   2010.1

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    DOI: 10.1016/j.neulet.2009.12.001

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  363. Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder Reviewed

    Hashimoto Ryota, Hashimoto Hitoshi, Shintani Norihito, Ohi Kazutaka, Hori Hiroaki, Saitoh Osamu, Kosuga Asako, Tatsumi Masahiko, Iwata Nakao, Ozaki Norio, Kamijima Kunitoshi, Baba Akemichi, Takeda Masatoshi, Kunugi Hiroshi

    NEUROSCIENCE LETTERS   Vol. 468 ( 3 ) page: 300-302   2010.1

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    DOI: 10.1016/j.neulet.2009.11.019

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  364. The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: Case-control studies and an updated meta-analysis Reviewed

    Nunokawa Ayako, Watanabe Yuichiro, Kaneko Naoshi, Sugai Takuro, Yazaki Saori, Arinami Tadao, Ujike Hiroshi, Inada Toshiya, Iwata Nakao, Kunugi Hiroshi, Sasaki Tsukasa, Itokawa Masanari, Ozaki Norio, Hashimoto Ryota, Someya Toshiyuki

    SCHIZOPHRENIA RESEARCH   Vol. 116 ( 1 ) page: 61-67   2010.1

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    DOI: 10.1016/j.schres.2009.10.016

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  365. A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects Reviewed

    Koide, Takayoshi; Aleksic, Branko; Ito, Yoshihito; Usui, Hinako; Yoshimi, Akira; Inada, Toshiya; Suzuki, Michio; Hashimoto, Ryota; Takeda, Masatoshi; Iwata, Nakao; Ozaki, Norio

    JOURNAL OF HUMAN GENETICS   Vol. 55 ( 7 ) page: 469-472   2010

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    DOI: 10.1038/jhg.2010.38

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  366. The expression of HMGA1a is increased in lymphoblastoid cell lines from schizophrenia patients Reviewed

    Morikawa Tomomi, Manabe Takayuki, Ito Yoshihito, Yamada Shinnosuke, Yoshimi Akira, Nagai Taku, Ozaki Norio, Mayeda Akila

    NEUROCHEMISTRY INTERNATIONAL   Vol. 56 ( 6-7 ) page: 736-739   2010

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    DOI: 10.1016/j.neuint.2010.03.011

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  367. Comparison of pharmacological profiles of serotonin norepinephrine reuptake inhibitors

    Adachi, Y. Aleksic, B. Ozaki, N.

    Clinical Neuropsychopharmacology and Therapeutics   Vol. 1   page: 10-15   2010

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  368. Effectiveness of Milnacipran for the Treatment of Chronic Pain in the Orofacial Region Reviewed

    Ito Mikiko, Kimura Hiroyuki, Yoshida Keizo, Kimura Yuki, Ozaki Norio, Kurita Kenichi

    CLINICAL NEUROPHARMACOLOGY   Vol. 33 ( 2 ) page: 79-83   2010

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    DOI: 10.1097/WNF.0b013e3181cb5793

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  369. Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder Reviewed

    Okuda Akiko, Suzuki Tatsuyo, Kishi Taro, Yamanouchi Yoshio, Umeda Kazunori, Haitoh Hiroshi, Hashimoto Shuji, Ozaki Norio, Iwata Nakao

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 64 ( 3 ) page: 268-273   2010

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    DOI: 10.1111/j.1440-1819.2010.02091.x

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  370. Genetic Association Analysis of Functional Polymorphisms in Neuronal Nitric Oxide Synthase 1 Gene (NOS1) and Mood Disorders and Fluvoxamine Response in Major Depressive Disorder in the Japanese Population Reviewed

    Okumura Takenori, Kishi Taro, Okochi Tomo, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Tsunoka Tomoko, Inada Toshiya, Ozaki Norio, Iwata Nakao

    NEUROPSYCHOBIOLOGY   Vol. 61 ( 2 ) page: 57-63   2010

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    DOI: 10.1159/000265130

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  371. Influence of chronic social defeat stress during neurodevelopmental stage on social behaviors Reviewed

    Ando Yu, Waki Yukari, Yamada Shinnosuke, Yoshimi Akira, Mouri Akihiro, Nabeshima Toshitaka, Ozaki Norio, Noda Yukihiro

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 112   page: 228P-228P   2010

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  372. Proteomic approach for the identification of potential biomarkers in schizophrenia Reviewed

    Yamada Shinnosuke, Nagai Taku, Yoshimi Akira, Ohashi Mitsuki, Ito Yoshihito, Noda Yukihiro, Ozaki Norio

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 112   page: 63P-63P   2010

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  373. Relationship of psychopathological symptoms and cognitive function to subjective quality of life in patients with chronic schizophrenia Reviewed

    Tomida Kenji, Takahashi Nagahide, Saito Shinichi, Maeno Nobuhisa, Iwamoto Kunihiro, Yoshido Keizo, Kimura Hiroyuki, Iidaka Tetsuya, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 64 ( 1 ) page: 62-69   2010

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    DOI: 10.1111/j.1440-1819.2009.02033.x

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  374. The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment Reviewed

    Schulze Thomas G., Alda Martin, Adli Mazda, Akula Nirmala, Ardau Raffaella, Bui Elise T., Chillotti Caterina, Cichon Sven, Czerski Piotr, Del Zompo Maria, Detera-Wadleigh Sevilla D., Grof Paul, Gruber Oliver, Hashimoto Ryota, Hauser Joanna, Hoban Rebecca, Iwata Nakao, Kassem Layla, Kato Tadafumi, Kittel-Schneider Sarah, Kliwicki Sebastian, Kelsoe John R., Kusumi Ichiro, Laje Gonzalo, Leckband Susan G., Manchia Mirko, MacQueen Glenda, Masui Takuya, Ozaki Norio, Perlis Roy H., Pfennig Andrea, Piccardi Paola, Richardson Sara, Rouleau Guy, Reif Andreas, Rybakowski Janusz K., Sasse Johanna, Schumacher Johannes, Severino Giovanni, Smoller Jordan W., Squassina Alessio, Turecki Gustavo, Young L. Trevor, Yoshikawa Takeo, Bauer Michael, McMahon Francis J.

    NEUROPSYCHOBIOLOGY   Vol. 62 ( 1 ) page: 72-78   2010

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    DOI: 10.1159/000314708

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  375. Preliminary Genome-Wide Association Study of Bipolar Disorder in the Japanese Population Reviewed

    Hattori Eiji, Toyota Tomoko, Ishitsuka Yuichi, Iwayama Yoshimi, Yamada Kazuo, Ujike Hiroshi, Morita Yukitaka, Kodama Masafumi, Nakata Kenji, Minabe Yoshio, Nakamura Kazuhiko, Iwata Yasuhide, Takei Nori, Mori Norio, Naitoh Hiroshi, Yamanouchi Yoshio, Iwata Nakao, Ozaki Norio, Kato Tadafumi, Nishikawa Toru, Kashiwa Atsushi, Suzuki Mika, Shioe Kunihiko, Shinohara Manabu, Hirano Masami, Nanko Shinichiro, Akahane Akihisa, Ueno Mikako, Kaneko Naoshi, Watanabe Yuichiro, Someya Toshiyuki, Hashimoto Kenji, Iyo Masaomi, Itokawa Masanari, Arai Makoto, Nankai Masahiro, Inada Toshiya, Yoshida Sumiko, Kunugi Hiroshi, Nakamura Michiko, Iijima Yoshimi, Okazaki Yuji, Higuchi Teruhiko, Yoshikawa Takeo

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 150B ( 8 ) page: 1110-1117   2009.12

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    DOI: 10.1002/ajmg.b.30941

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  376. Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia Reviewed

    Ueno Hitomi, Nishigaki Yutaka, Kong Qing-Peng, Fuku Noriyuki, Kojima Shuji, Iwata Nakao, Ozaki Norio, Tanaka Masashi

    MITOCHONDRION   Vol. 9 ( 6 ) page: 385-393   2009.11

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    DOI: 10.1016/j.mito.2009.06.003

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  377. Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis Reviewed

    Kishi Taro, Tsunoka Tomoko, Ikeda Masashi, Kawashima Kunihiro, Okochi Tomo, Kitajima Tsuyoshi, Kinoshita Yoko, Okumura Takenori, Yamanouchi Yoshio, Inada Toshiya, Ozaki Norio, Iwata Nakao

    JOURNAL OF HUMAN GENETICS   Vol. 54 ( 11 ) page: 629-633   2009.11

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    DOI: 10.1038/jhg.2009.84

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  378. Gender difference in relationship between anxiety-related personality traits and cerebral brain glucose metabolism Reviewed

    Hakamata Yuko, Iwase Mikio, Iwata Hiroshi, Kobayashi Toshiki, Tamaki Tsuneo, Nishio Masami, Matsuda Hiroshi, Ozaki Norio, Inada Toshiya

    PSYCHIATRY RESEARCH-NEUROIMAGING   Vol. 173 ( 3 ) page: 206-211   2009.9

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    DOI: 10.1016/j.pscychresns.2008.10.002

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  379. No association between the Bcl2-interacting killer (BIK) gene and schizophrenia Reviewed

    Ohi Kazutaka, Hashimoto Ryota, Yasuda Yuka, Yamamori Hidenaga, Hori Hiroaki, Saitoh Osamu, Tatsumi Masahiko, Takeda Masatoshi, Iwata Nakao, Ozaki Norio, Kamijima Kunitoshi, Kunugi Hiroshi

    NEUROSCIENCE LETTERS   Vol. 463 ( 1 ) page: 60-63   2009.9

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    DOI: 10.1016/j.neulet.2009.07.063

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  380. Association of AKT1 with schizophrenia confirmed in a Japanese population (vol 56, pg 698, 2004) Reviewed

    Ikeda M., Iwata N., Suzuki T., Kitajima T., Yamanouchi Y., Kinoshita Y., Inada T., Ozaki N.

    BIOLOGICAL PSYCHIATRY   Vol. 66 ( 5 ) page: 527-527   2009.9

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    DOI: 10.1016/j.biopsych.2009.07.012

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  381. The disrupted-in-schizophrenia-1 ser704cys polymorphism and brain morphology in schizophrenia Reviewed

    Suzuki M., Takahashi T., Tsunoda M., Maeno N., Kawasaki Y., Zhou S., Tsuneki H., Kobayashi S., Kurachi M., Ozaki N.

    EUROPEAN NEUROPSYCHOPHARMACOLOGY   Vol. 19   page: S305-S305   2009.9

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  382. Expression of neprilysin, somatostatin and the somatostatin sst(5) receptor in the hippocampal formation of brains from Alzheimer's disease patients Reviewed

    Sekiguchi Hirotaka, Habuchi Chikako, Iritani Shuji, Arai Tetsuaki, Ozaki Norio

    PSYCHOGERIATRICS   Vol. 9 ( 3 ) page: 132-138   2009.9

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    DOI: 10.1111/j.1479-8301.2009.00285.x

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  383. G72 gene is associated with susceptibility to methamphetamine psychosis Reviewed

    Kotaka Tatsuya, Ujike Hiroshi, Okahisa Yuko, Takaki Manabu, Nakata Kenji, Kodama Masafumi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Kuroda Shigetoshi

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   Vol. 33 ( 6 ) page: 1046-1049   2009.8

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    DOI: 10.1016/j.pnpbp.2009.05.017

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  384. A functional polymorphism in estrogen receptor alpha gene is associated with Japanese methamphetamine induced psychosis Reviewed

    Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Tsunoka Tomoko, Okumura Takenori, Inada Toshiya, Ujike Hiroshi, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   Vol. 33 ( 5 ) page: 895-898   2009.8

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    DOI: 10.1016/j.pnpbp.2009.04.008

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  385. Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population Reviewed

    Okochi Tomo, Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Kinoshita Yoko, Kawashima Kunihiro, Okumura Takenori, Tsunoka Tomoko, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Ujike Hiroshi, Iwata Nakao

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   Vol. 33 ( 5 ) page: 903-905   2009.8

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    DOI: 10.1016/j.pnpbp.2009.04.016

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  386. Association analysis of Group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population Reviewed

    Tsunoka Tomoko, Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Inada Toshiya, Ozaki Norio, Iwata Nakao

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   Vol. 33 ( 5 ) page: 875-879   2009.8

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    DOI: 10.1016/j.pnpbp.2009.04.007

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  387. Association analysis of functional polymorphism in estrogen receptor alpha gene with schizophrenia and mood disorders in the Japanese population Reviewed

    Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Tsunoka Tomoko, Inada Toshiya, Ozaki Norio, Iwata Nakao

    PSYCHIATRIC GENETICS   Vol. 19 ( 4 ) page: 217-218   2009.8

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    DOI: 10.1097/YPG.0b013e32832cee98

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  388. Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population Reviewed

    Kishi Taro, Kitajima Tsuyoshi, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Tsunoka Tomoko, Inada Toshiya, Ozaki Norio, Iwata Nakao

    EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE   Vol. 259 ( 5 ) page: 293-297   2009.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00406-009-0869-4

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  389. Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia Reviewed

    Koga Minori, Ishiguro Hiroki, Yazaki Saori, Horiuchi Yasue, Arai Makoto, Niizato Kazuhiro, Iritani Shuji, Itokawa Masanari, Inada Toshiya, Iwata Nakao, Ozaki Norio, Ujike Hiroshi, Kunugi Hiroshi, Sasaki Tsukasa, Takahashi Makoto, Watanabe Yuichiro, Someya Toshiyuki, Kakita Akiyoshi, Takahashi Hitoshi, Nawa Hiroyuki, Muchardt Christian, Yaniv Moshe, Arinami Tadao

    HUMAN MOLECULAR GENETICS   Vol. 18 ( 13 ) page: 2483-2494   2009.7

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    DOI: 10.1093/hmg/ddp166

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  390. A two-stage case-control association study of PADI2 with schizophrenia Reviewed

    Watanabe Yuichiro, Nunokawa Ayako, Kaneko Naoshi, Arinami Tadao, Ujike Hiroshi, Inada Toshiya, Iwata Nakao, Kunugi Hiroshi, Itokawa Masanari, Otowa Takeshi, Ozaki Norio, Someya Toshiyuki

    JOURNAL OF HUMAN GENETICS   Vol. 54 ( 7 ) page: 430-432   2009.7

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    DOI: 10.1038/jhg.2009.52

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  391. BDNF is not associated with schizophrenia: Data from a Japanese population study and meta-analysis Reviewed

    Kawashima Kunihiro, Ikeda Masashi, Kishi Taro, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Okochi Tomo, Aleksic Branko, Tomita Makoto, Okada Takeya, Kunugi Hiroshi, Inada Toshiya, Ozaki Norio, Iwata Nakao

    SCHIZOPHRENIA RESEARCH   Vol. 112 ( 1-3 ) page: 72-79   2009.7

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    DOI: 10.1016/j.schres.2009.03.040

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  392. Tumor necrosis factor receptor-associated protein 1 regulates cell adhesion and synaptic morphology via modulation of N-cadherin expression Reviewed

    Kubota Kyoko, Inoue Kiyoshi, Hashimoto Ryota, Kumamoto Natsuko, Kosuga Asako, Tatsumi Masahiko, Kamijima Kunitoshi, Kunugi Hiroshi, Iwata Nakao, Ozaki Norio, Takeda Masatoshi, Tohyama Masaya

    JOURNAL OF NEUROCHEMISTRY   Vol. 110 ( 2 ) page: 496-508   2009.7

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    DOI: 10.1111/j.1471-4159.2009.06099.x

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  393. Genetic variants of D2 but not D3 or D4 dopamine receptor gene are associated with rapid onset and poor prognosis of methamphetamine psychosis Reviewed

    Ujike Hiroshi, Katsu Takeshi, Okahisa Yuko, Takaki Manabu, Kodama Masafumi, Inada Toshiya, Uchimura Naohisa, Yamada Mitsuhiko, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Kuroda Shigetoshi

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   Vol. 33 ( 4 ) page: 625-629   2009.6

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    DOI: 10.1016/j.pnpbp.2009.02.019

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  394. Upper airway morphology in patients with obstructive sleep apnea syndrome: Effects of lateral positioning Reviewed

    Soga Taro, Nakata Seiichi, Yasuma Fumihiko, Noda Akiko, Sugiura Tatsuki, Yatsuya Hiroshi, Koike Yasuo, Ozaki Norio, Nakashima Tsutomu

    AURIS NASUS LARYNX   Vol. 36 ( 3 ) page: 305-309   2009.6

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    DOI: 10.1016/j.anl.2008.04.007

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  395. CLOCK may Predict the Response to Fluvoxamine Treatment in Japanese Major Depressive Disorder Patients Reviewed

    Kishi Taro, Kitajima Tsuyoshi, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Tsunoka Tomoko, Ozaki Norio, Iwata Nakao

    NEUROMOLECULAR MEDICINE   Vol. 11 ( 2 ) page: 53-57   2009.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12017-009-8060-7

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  396. Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population Reviewed

    Kishi Taro, Kitajima Tsuyoshi, Tsunoka Tomoko, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Inada Toshiya, Ozaki Norio, Iwata Nakao

    NEUROSCIENCE RESEARCH   Vol. 64 ( 2 ) page: 231-234   2009.6

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    DOI: 10.1016/j.neures.2009.03.003

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  397. No Association Between Polymorphisms of Neuronal Oxide Synthase 1 Gene (NOS1) and Schizophrenia in a Japanese Population Reviewed

    Okumura Takenori, Okochi Tomo, Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Tsunoka Tomoko, Ujike Hiroshi, Inada Toshiya, Ozaki Norio, Iwata Nakao

    NEUROMOLECULAR MEDICINE   Vol. 11 ( 2 ) page: 123-127   2009.6

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    DOI: 10.1007/s12017-009-8068-z

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  398. Possible Association of Prokineticin 2 Receptor Gene (PROKR2) with Mood Disorders in the Japanese Population Reviewed

    Kishi Taro, Kitajima Tsuyoshi, Tsunoka Tomoko, Okumura Takenori, Ikeda Masashi, Okochi Tomo, Kinoshita Yoko, Kawashima Kunihiro, Yamanouchi Yoshio, Ozaki Norio, Iwata Nakao

    NEUROMOLECULAR MEDICINE   Vol. 11 ( 2 ) page: 114-122   2009.6

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    DOI: 10.1007/s12017-009-8067-0

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  399. An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis Reviewed

    Nakamura Kazuhiko, Sekine Yoshimoto, Takei Noriyoshi, Iwata Yasuhide, Suzuki Katsuaki, Anitha Ayyappan, Inada Toshiya, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Iwata Nakao, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Ujike Hiroshi, Mori Norio

    NEUROSCIENCE LETTERS   Vol. 455 ( 2 ) page: 120-123   2009.5

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    DOI: 10.1016/j.neulet.2009.02.048

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  400. Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia Reviewed

    Shibata Hiroki, Tani Ayako, Chikuhara Tomoyuki, Kikuta Rumiko, Sakai Mayurril, Ninomiya Hideaki, Tashiro Nobutada, Iwata Nakao, Ozaki Norio, Fukumaki Yasuyuki

    PSYCHIATRY RESEARCH   Vol. 167 ( 1-2 ) page: 88-96   2009.5

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    DOI: 10.1016/j.psychres.2007.12.002

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  401. The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia Reviewed

    Takahashi Tsutomu, Suzuki Michio, Tsunoda Masahiko, Maeno Nobuhisa, Kawasaki Yasuhiro, Zhou Shi-Yu, Hagino Hirofumi, Niu Lisha, Tsuneki Hiroshi, Kobayashi Soushi, Sasaoka Toshiyasu, Seto Hikaru, Kurachi Masayoshi, Ozaki Norio

    PSYCHIATRY RESEARCH-NEUROIMAGING   Vol. 172 ( 2 ) page: 128-135   2009.5

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    DOI: 10.1016/j.pscychresns.2009.01.005

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  402. Meta-analysis of association between genetic variants in COMT and schizophrenia: An update Reviewed

    Okochi Tomo, Ikeda Masashi, Kishi Taro, Kawashima Kunihiro, Kinoshita Yoko, Kitajima Tsuyoshi, Yamanouchi Yoshio, Tomita Makoto, Inada Toshiya, Ozaki Norio, Iwata Nakao

    SCHIZOPHRENIA RESEARCH   Vol. 110 ( 1-3 ) page: 140-148   2009.5

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    DOI: 10.1016/j.schres.2009.02.019

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  403. Association study of the G72 gene with schizophrenia in a Japanese population: A multicenter study Reviewed

    Ohi Kazutaka, Hashimoto Ryota, Yasuda Yuka, Yoshida Tetsuhiko, Takahashi Hidetoshi, Iike Naomi, Fukumoto Motoyuki, Takamura Hironori, Iwase Masao, Kamino Kouzin, Ishii Ryouhei, Kazui Hiroaki, Sekiyama Ryuji, Kitamura Yuri, Azechi Michiyo, Ikezawa Koji, Kurimoto Ryu, Kamagata Eiichiro, Tanimukai Hitoshi, Tagami Shinji, Morihara Takashi, Ogasawara Masayuki, Okochi Masayasu, Tokunaga Hiromasa, Numata Shusuke, Ikeda Masashi, Ohnuma Tohru, Ueno Shu-ichi, Fukunaga Tomoko, Tanaka Toshihisa, Kudo Takashi, Arai Heii, Ohmori Tetsuro, Iwata Nakao, Ozaki Norio, Takeda Masatoshi

    SCHIZOPHRENIA RESEARCH   Vol. 109 ( 1-3 ) page: 80-85   2009.4

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    DOI: 10.1016/j.schres.2009.01.019

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  404. Association Study Between the PIK4CA Gene and Methamphetamine Use Disorder in a Japanese Population Reviewed

    Kanahara Nobuhisa, Miyatake Ryosuke, Sekine Yoshimoto, Inada Toshiya, Ozaki Norio, Iwata Nakao, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Sora Ichiro, Ujike Hiroshi, Iyo Masaomi, Hashimoto Kenji

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 150B ( 2 ) page: 233-238   2009.3

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    DOI: 10.1002/ajmg.b.30797

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  405. Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia Reviewed

    Arai Shinsaku, Shibata Hiroki, Sakai Mayumi, Ninomiya Hideaki, Iwata Nakao, Ozaki Norio, Fukumaki Yasuyuki

    PSYCHIATRIC GENETICS   Vol. 19 ( 1 ) page: 6-13   2009.2

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    DOI: 10.1097/YPG.0b013e328311875d

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  406. Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia Reviewed

    Watanabe Yuichiro, Nunokawa Ayako, Kaneko Naoshi, Muratake Tatsuyuki, Arinami Tadao, Ujike Hiroshi, Inada Toshiya, Iwata Nakao, Kunugi Hiroshi, Itokawa Masanari, Otowa Takeshi, Ozaki Norio, Someya Toshiyuki

    JOURNAL OF HUMAN GENETICS   Vol. 54 ( 1 ) page: 62-65   2009.1

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    DOI: 10.1038/jhg.2008.4

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  407. A link between stress and depression: Shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression Reviewed

    Miura Hideki, Ozaki Norio, Sawada Makoto, Isobe Kenichi, Ohta Tatsuro, Nagatsu Toshiharu

    STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS   Vol. 12 ( 5 ) page: 198-209   2009

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  408. Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence Reviewed

    Okahisa Yuko, Ujike Hiroshi, Kotaka Tatsuya, Morita Yukitaka, Kodama Masafumi, Inada Toshiya, Yamada Mitsuhiko, Iwata Nakao, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Kuroda Shigetoshi

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 63 ( 3 ) page: 417-422   2009

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    DOI: 10.1111/j.1440-1819.2009.01961.x

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  409. Dense association mapping of dihydropyrimidinase-like 2 (DPYSL2) gene in susceptibility to schizophrenia in a Japanese population Reviewed

    Ito Yoshihito, Koide Takayoshi, Aleksic Branko, Inada Toshiya, Iwata Nakao, Ozaki Norio

    NEUROSCIENCE RESEARCH   Vol. 65   page: S253-S253   2009

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    DOI: 10.1016/j.neures.2009.09.1441

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  410. Distribution of neurofibrillary tangles in diffuse neurofibrillary tangles with calcification Reviewed

    Ukai Katsuyuki, Shibayama Hiroto, Ishihara Ryoko, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 63 ( 5 ) page: 646-651   2009

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    DOI: 10.1111/j.1440-1819.2009.02000.x

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  411. Orphan Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Fluvoxamine Response in Major Depressive Disorder in the Japanese Population Reviewed

    Kishi Taro, Kitajima Tsuyoshi, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Ozaki Norio, Iwata Nakao

    NEUROPSYCHOBIOLOGY   Vol. 59 ( 4 ) page: 234-238   2009

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    DOI: 10.1159/000226612

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  412. Practice-based depression screening for psychiatry outpatients: Feasibility comparison of two-types of Center for Epidemiologic Studies Depression Scales Reviewed

    Nishiyama Takeshi, Ozaki Norio, Iwata Nakao

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 63 ( 5 ) page: 632-638   2009

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    DOI: 10.1111/j.1440-1819.2009.02003.x

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  413. Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice Reviewed

    Miura Hideki, Shirokawa Tetsuya, Isobe Kenichi, Ozaki Norio

    STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS   Vol. 12 ( 3 ) page: 206-214   2009

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    DOI: 10.1080/10253890802252442

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  414. The roles of glutamate transporter, GLAST in learning and memory, and emotion Reviewed

    Waki Yukari, Murai Rina, Yoshimi Akira, Yamada Shinnosuke, Ando Yu, Mouri Akihiro, Ozaki Norio, Yamada Kiyofumi, Tanaka Kohichi, Noda Yukihiro, Nabeshima Toshitaka

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 109   page: 126P-126P   2009

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  415. Sleep and lifestyle habits in morning and evening types of human circadian rhythm Reviewed

    Sukegawa Mayo, Noda Akiko, Morishita Yuki, Ochi Hikari, Miyata Seiko, Honda Kumiko, Maeno Nobuhisa, Ozaki Norio, Koike Yasuo

    BIOLOGICAL RHYTHM RESEARCH   Vol. 40 ( 2 ) page: 121-127   2009

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    DOI: 10.1080/09291010701794404

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  416. Use of questionnaire infeasibility in order to detect cognitive disorders: Example of the Center for Epidemiologic Studies Depression Scale in psychiatry settings Reviewed

    Nishiyama Takeshi, Ozaki Norio, Iwata Nakao

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 63 ( 1 ) page: 23-29   2009

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    DOI: 10.1111/j.1440-1819.2008.01902.x

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  417. Association analysis between the protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) gene and schizophrenia in the Japanese population Reviewed

    Yamada Shinnosuke, Ito Yoshihito, Yoshimi Akira, Noda Yukihiro, Ozaki Norio

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 109   page: 208P-208P   2009

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  418. A novel molecule 'shati' increases dopamine uptake via the induction of tumor necrosis factor-alpha in pheochromocytoma-12 cells Reviewed

    Niwa Minae, Nitta Atsumi, Cen Xiaobo, Kitaichi Kiyoyuki, Ozaki Norio, Yamada Kiyofumi, Nabeshima Toshitaka

    JOURNAL OF NEUROCHEMISTRY   Vol. 107 ( 6 ) page: 1697-1708   2008.12

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    DOI: 10.1111/j.1471-4159.2008.05738.x

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  419. Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population Reviewed

    Kishi Taro, Kitajima Tsuyoshi, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Ozaki Norio, Iwata Nakao

    NEUROSCIENCE RESEARCH   Vol. 62 ( 4 ) page: 211-215   2008.12

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    DOI: 10.1016/j.neures.2008.08.008

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  420. Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia Reviewed

    Ikeda, Masashi; Hikita, Takao; Taya, Shinichiro; Uraguchi-Asaki, Junko; Toyo-oka, Kazuhito; Wynshaw-Boris, Anthony; Ujike, Hiroshi; Inada, Toshiya; Takao, Keizo; Miyakawa, Tsuyoshi; Ozaki, Norio; Kaibuchi, Kozo; Iwata, Nakao

    HUMAN MOLECULAR GENETICS   Vol. 17 ( 20 ) page: 3212-3222   2008.10

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    DOI: 10.1093/hmg/ddn217

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  421. No Association Between the Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 (PTPRZ1) Gene and Schizophrenia in the Japanese Population Reviewed

    Ito Yoshihito, Yamada Shinnosuke, Takahashi Nagahide, Saito Shinichi, Yoshimi Akira, Inada Toshiya, Noda Yukihiro, Ozaki Norio

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 147B ( 7 ) page: 1013-1018   2008.10

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    DOI: 10.1002/ajmg.b.30692

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  422. Association Study Between Polymorphisms in Glutathione-Related Genes and Methamphetamine Use Disorder in a Japanese Population Reviewed

    Hashimoto Tasuku, Hashimoto Kenji, Miyatake Ryosuke, Matsuzawa Daisuke, Sekine Yoshimoto, Inada Toshiya, Ozaki Norio, Iwata Nakao, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Sora Ichiro, Ujike Hiroshi, Iyo Masaomi

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 147B ( 7 ) page: 1040-1046   2008.10

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    DOI: 10.1002/ajmg.b.30703

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  423. No Association Between Tagging SNPs of SNARE Complex Genes (STX1A, VAMP2 and SNAP25) and Schizophrenia in a Japanese Population Reviewed

    Kawashima Kunihiro, Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Takahashi Nagahide, Saito Shinichi, Ohi Kazutaka, Yasuda Yuka, Hashimoto Ryota, Takeda Masatoshi, Inada Toshiya, Ozaki Norio, Iwata Nakao

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 147B ( 7 ) page: 1327-1331   2008.10

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    DOI: 10.1002/ajmg.b.30781

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  424. Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia Reviewed

    Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kitajima Tsuyoshi, Yoshimura Reiji, Hashimoto Shuji, O'Donovan Michael C., Nakamura Jun, Ozaki Norio, Iwata Nakao

    PHARMACOGENOMICS   Vol. 9 ( 10 ) page: 1437-1443   2008.10

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    DOI: 10.2217/14622416.9.10.1437

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  425. Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (CHRNA4 and CHRNB2) with schizophrenia in the Japanese population Reviewed

    Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Inada Toshiya, Ozaki Norio, Iwata Nakao

    JOURNAL OF NEURAL TRANSMISSION   Vol. 115 ( 10 ) page: 1457-1461   2008.10

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    DOI: 10.1007/s00702-008-0114-8

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  426. Plasma amitriptyline level after acute administration, and driving performance in healthy volunteers Reviewed

    Iwamoto Kunihiro, Kawamura Yukiko, Takahashi Masahiro, Uchiyama Yuji, Ebe Kazutoshi, Yoshida Keizo, Iidaka Tetsuya, Noda Yukihiro, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 62 ( 5 ) page: 610-616   2008.10

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    DOI: 10.1111/j.1440-1819.2008.01838.x

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  427. Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia Reviewed

    Ishiguro Hiroki, Imai Keiko, Koga Minori, Horiuchi Yasue, Inada Toshiya, Iwata Nakao, Ozaki Norio, Ujike Hiroshi, Itokawa Masanari, Kunugi Hiroshi, Sasaki Tsukasa, Watanabe Yuichiro, Someya Toshiyuki, Arinami Tadao

    PSYCHIATRIC GENETICS   Vol. 18 ( 5 ) page: 255-256   2008.10

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    DOI: 10.1097/YPG.0b013e328306c7dc

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  428. Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders Reviewed

    Yamasaki, Nobuyuki; Maekawa, Motoko; Kobayashi, Katsunori; Kajii, Yasushi; Maeda, Jun; Soma, Miho; Takao, Keizo; Tanda, Koichi; Ohira, Koji; Toyama, Keiko; Kanzaki, Kouji; Fukunaga, Kohji; Sudo, Yusuke; Ichinose, Hiroshi; Ikeda, Masashi; Iwata, Nakao; Ozaki, Norio; Suzuki, Hidenori; Higuchi, Makoto; Suhara, Tetsuya; Yuasa, Shigeki; Miyakawa, Tsuyoshi

    MOLECULAR BRAIN   Vol. 1   page: 6   2008.9

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    DOI: 10.1186/1756-6606-1-6

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  429. No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population Reviewed

    Aleksic Branko, Ikeda Masashi, Ishihara Ryoko, Saito Shinichi, Inada Toshiya, Iwata Nakao, Ozaki Norio

    JOURNAL OF HUMAN GENETICS   Vol. 53 ( 9 ) page: 863-866   2008.9

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    DOI: 10.1007/s10038-008-0318-7

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  430. The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population Reviewed

    Kishimoto Makiko, Ujike Hiroshi, Okahisa Yuko, Kotaka Tatsuya, Takaki Manabu, Kodama Masafumi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Kuroda Shigetoshi

    BEHAVIORAL AND BRAIN FUNCTIONS   Vol. 4   2008.8

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    DOI: 10.1186/1744-9081-4-37

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  431. Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia Reviewed

    Deng Xiangdong, Sagata Noriaki, Takeuchi Naoko, Tanaka Masami, Ninomiya Hideaki, Iwata Nakao, Ozaki Norio, Shibata Hiroki, Fukumaki Yasuyuki

    BMC PSYCHIATRY   Vol. 8   2008.7

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    DOI: 10.1186/1471-244X-8-58

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  432. Up-regulation of ADM and SEPX1 in the lymphoblastoid cells of patients in monozygotic twins discordant for schizophrenia Reviewed

    Kakiuchi Chihiro, Ishiwata Mizuho, Nanko Shinichiro, Ozaki Norio, Iwata Nakao, Umekage Tadashi, Tochigi Mamoru, Kohda Kazuhisa, Sasaki Tsukasa, Imamura Akira, Okazaki Yuji, Kato Tadafumi

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 147B ( 5 ) page: 557-564   2008.7

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    DOI: 10.1002/ajmg.b.30643

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  433. The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures Reviewed

    Takahashi Tsutomu, Suzuki Michio, Tsunoda Masahiko, Kawamura Yukiko, Takahashi Nagahide, Maeno Nobuhisa, Kawasaki Yasuhiro, Zhou Shi-Yu, Hagino Hirofumi, Niu Lisha, Tsuneki Hiroshi, Kobayashi Soushi, Sasaoka Toshiyasu, Seto Hikaru, Kurachi Masayoshi, Ozaki Norio

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   Vol. 32 ( 5 ) page: 1236-1242   2008.7

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    DOI: 10.1016/j.pnpbp.2008.03.014

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  434. The effects of acute treatment with paroxetine, amitriptyline, and placebo on driving performance and cognitive function in healthy Japanese subjects: A double-blind crossover trial Reviewed

    Iwamoto Kunihiro, Takahashi Masahiro, Nakamura Yukako, Kawamura Yukiko, Ishihara Ryoko, Uchiyama Yuji, Ebe Kazutoshi, Noda Akiko, Noda Yukihiro, Yoshida Keizo, Iidaka Tetsuya, Ozaki Norio

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 23 ( 5 ) page: 399-407   2008.7

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    DOI: 10.1002/hup.939

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  435. A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6) gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population Reviewed

    Ito Yoshihito, Nakamura Yukako, Takahashi Nagahide, Saito Shinichi, Aleksic Branko, Iwata Nakao, Inada Toshiya, Ozaki Norio

    NEUROSCIENCE LETTERS   Vol. 438 ( 1 ) page: 70-75   2008.6

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    DOI: 10.1016/j.neulet.2008.04.010

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  436. No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a Japanese population Reviewed

    Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Suzuki Tatsuyo, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Ozaki Norio, Iwata Nakao

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 147B ( 4 ) page: 531-534   2008.6

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    DOI: 10.1002/ajmg.b.30634

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  437. Association of polymorphisms in the haplotype block spanning the alternatively spliced exons of the NTNG1 gene at 1p13.3 with schizophrenia in Japanese populations Reviewed

    Ohtsuki T., Horiuchi Y., Koga M., Ishiguro H., Inada T., Iwata N., Ozaki N., Ujike H., Watanabe Y., Someya T., Arinami T.

    NEUROSCIENCE LETTERS   Vol. 435 ( 3 ) page: 194-197   2008.4

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    DOI: 10.1016/j.neulet.2008.02.053

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  438. Relationship between three serotonin receptor subtypes (HTR3A, HTR2A and HTR4) and treatment-resistant schizophrenia in the Japanese population Reviewed

    Ji Xiaofei, Takahashi Nagahide, Saito Shinichi, Ishihara Ryoko, Maeno Nobuhisa, Inada Toshiya, Ozaki Norio

    NEUROSCIENCE LETTERS   Vol. 435 ( 2 ) page: 95-98   2008.4

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    DOI: 10.1016/j.neulet.2008.01.083

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  439. Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons Reviewed

    Takahashi Tsutomu, Suzuki Michio, Tsunoda Masahiko, Kawamura Yukiko, Takahashi Nagahide, Tsuneki Hiroshi, Kawasaki Yasuhiro, Zhou Shi-Yu, Kobayashi Soushi, Sasaoka Toshiyasu, Seto Hikaru, Kurachi Masayoshi, Ozaki Norio

    NEUROSCIENCE LETTERS   Vol. 435 ( 1 ) page: 34-39   2008.4

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    DOI: 10.1016/j.neulet.2008.02.004

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  440. Replication study and meta-analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case-control population Reviewed

    Albalushi Talal, Horiuchi Yasue, Ishiguro Hiroki, Koga Minori, Inada Toshiya, Iwata Nakao, Ozaki Norio, Ujike Hiroshi, Watanabe Yuichiro, Someya Toshiyuki, Arinami Tadao

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 147B ( 3 ) page: 392-396   2008.4

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    DOI: 10.1002/ajmg.b.30610

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  441. A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia Reviewed

    Ohtsuki Tsuyuka, Koga Minori, Ishiguro Hiroki, Horiuchi Yasue, Arai Makoto, Niizato Kazuhiro, Itokawa Masanari, Inada Toshiya, Iwata Nakao, Iritani Shyuji, Ozaki Norio, Kunugi Hiroshi, Ujike Hiroshi, Watanabe Yuichiro, Someya Toshiuki, Arinami Tadao

    SCHIZOPHRENIA RESEARCH   Vol. 101 ( 1-3 ) page: 9-16   2008.4

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    DOI: 10.1016/j.schres.2008.01.027

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  442. Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample Reviewed

    Ikeda Masashi, Takahashi Nagahide, Saito Shinichi, Aleksic Branko, Watanabe Yuichiro, Nunokawa Ayako, Yamanouchi Yoshio, Kitajima Tsuyoshi, Kinoshita Yoko, Kishi Taro, Kawashima Kunihiro, Hashimoto Ryota, Ujike Hiroshi, Inada Toshiya, Someya Toshiyuki, Takeda Masatoshi, Ozaki Norio, Iwata Nakao

    SCHIZOPHRENIA RESEARCH   Vol. 101 ( 1-3 ) page: 1-8   2008.4

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    DOI: 10.1016/j.schres.2008.01.010

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  443. Large-scale case-control study of a functional polymorphism in the glutamate receptor, metabotropic 3 gene in patients with schizophrenia Reviewed

    Nunokawa Ayako, Watanabe Yuichiro, Kitamura Hideaki, Kaneko Naoshi, Arinami Tadao, Ujike Hiroshi, Inada Toshiya, Iwata Nakao, Kunugi Hiroshi, Itokawa Masanari, Ozaki Norio, Someya Toshiyuki

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 62 ( 2 ) page: 239-240   2008.4

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    DOI: 10.1111/j.1440-1819.2008.01762.x

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  444. Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia Reviewed

    Inada Toshiya, Koga Minori, Ishiguro Hiroki, Horiuchi Yasue, Syu Aoi, Yoshio Takashi, Takahashi Nagahide, Ozaki Norio, Arinami Tadao

    PHARMACOGENETICS AND GENOMICS   Vol. 18 ( 4 ) page: 317-323   2008.4

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  445. Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins Reviewed

    Kuratomi G., Iwamoto K., Bundo M., Kusumi I., Kato N., Iwata N., Ozaki N., Kato T.

    MOLECULAR PSYCHIATRY   Vol. 13 ( 4 ) page: 429-441   2008.4

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    DOI: 10.1038/sj.mp.4002001

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  446. Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence Reviewed

    Otani Kyohei, Ujike Hiroshi, Sakai Ayumu, Okahisa Yuko, Kotaka Tatsuya, Inada Toshiya, Harano Mutsuo, Komiyama Tokutaro, Hori Toru, Yamada Mitsuhiko, Sekine Yoshimoto, Iwata Nakao, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Kuroda Shigetoshi

    NEUROSCIENCE LETTERS   Vol. 434 ( 1 ) page: 88-92   2008.3

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    DOI: 10.1016/j.neulet.2008.01.033

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  447. An association study of tachykinin receptor 3 gene with schizophrenia in the Japanese population Reviewed

    Saito Shinichi, Takahashi Nagahide, Maeno Nobuhisa, Ito Yoshihito, Aleksic Branko, Usui Hinako, Iidaka Tetsuya, Inada Toshiya, Ozaki Norio

    NEUROREPORT   Vol. 19 ( 4 ) page: 471-473   2008.3

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  448. Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea Reviewed

    Tanaka Misuzu, Kobayashi Daisuke, Murakami Yuko, Ozaki Norio, Suzuki Tatsuyo, Iwata Nakao, Haraguchi Koichi, Ieiri Ichiro, Kinukawa Naoko, Hosoi Masako, Ohtani Hisakazu, Sawada Yasufumi, Mine Kazunori

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   Vol. 11 ( 2 ) page: 261-267   2008.3

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    DOI: 10.1017/S1461145707007985

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  449. Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder Reviewed

    Yoshimi Akira, Takahashi Nagahide, Saito Shinichi, Ito Yoshihito, Aleksic Branko, Usui Hinako, Kawamura Yukiko, Waki Yukari, Yoshikawa Takeo, Kato Tadafumi, Iwata Nakao, Inada Toshiya, Noda Yukihiro, Ozaki Norio

    SCHIZOPHRENIA RESEARCH   Vol. 100 ( 1-3 ) page: 334-341   2008.3

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    DOI: 10.1016/j.schres.2007.10.028

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  450. Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val158met polymorphism on the antidepressant effect of milnacipran Reviewed

    Yoshida Keizo, Higuchi Hisashi, Takahashi Hitoshi, Kamata Mitsuhiro, Sato Kazuhiro, Inoue Kazuyuki, Suzuki Toshio, Itoh Kunihiko, Ozaki Norio

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 23 ( 2 ) page: 121-128   2008.3

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    DOI: 10.1002/hup.907

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  451. Genome-wide association for methamphetamine dependence Reviewed

    Uhl George R., Drgon Tomas, Liu Qing-Rong, Johnson Catherine, Walther Donna, Komiyama Tokutaro, Harano Mutsuo, Sekine Yoshimoto, Inada Toshiya, Ozaki Norio, Iyo Masaomi, Iwata Nakao, Yamada Mitsuhiko, Sora Ichiro, Chen Chih-Ken, Liu Hsing-Cheng, Ujike Hiroshi, Lin Shih-Ku

    ARCHIVES OF GENERAL PSYCHIATRY   Vol. 65 ( 3 ) page: 345-355   2008.3

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  452. Association analysis of MTHFR gene in schizophrenia Reviewed

    Kawamura Y., Takahashi N., Saito S., Usui H., Yoshimi A., Ito Y., Branko A., Ishihara R., Yoshida K., Iidaka T., Inada T., Iwata N., Noda Y., Ozaki N.

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 62 ( 1 ) page: S4-S5   2008.2

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  453. Association study and copy number analysis of the DARPP-32 gene in bipolar disorder Reviewed

    Yoshimi A., Takahashi N., Kawamura Y., Kato T., Kaneda N., Saito S., Usui H., Ishihara R., Inada T., Yoshikawa T., Kato T., Iwata N., Noda Y., Ozaki N.

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 62 ( 1 ) page: S5-S6   2008.2

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  454. The dysbindin gene (DTNBP1) is associated with methamphetamine psychosis Reviewed

    Kishimoto Makiko, Ujike Hiroshi, Motohashi Yasuko, Tanaka Yuji, Kahisa Yuko, Kotaka Tatsuya, Harano Mutsuo, Inada Toshiya, Yamada Mitsuhiko, Komiyama Tokutaro, Hori Toru, Sekine Yoshimoto, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Kuroda Shigetoshi

    BIOLOGICAL PSYCHIATRY   Vol. 63 ( 2 ) page: 191-196   2008.1

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    DOI: 10.1016/j.biopsych.2007.03.019

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  455. The Glycine Transporter 1 Gene (GLYT1) Is Associated With Methamphetamine-Use Disorder Reviewed

    Morita Yukitaka, Ujike Hiroshi, Tanaka Yuji, Kishimoto Makiko, Okahisa Yuko, Kotaka Tatsuya, Harano Mutsuo, Inada Toshiya, Komiyama Tokutaro, Hori Toru, Yamada Mitsuhiko, Sekine Yoshimoto, Iwata Nakao, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Kuroda Shigetoshi

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 147B ( 1 ) page: 54-58   2008.1

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    DOI: 10.1002/ajmg.b.30565

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  456. A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder Reviewed

    Masui Takuya, Hashimoto Ryota, Kusumi Ichiro, Suzuki Katsuji, Tanaka Teruaki, Nakagawa Shin, Suzuki Tatsuyo, Iwata Nakao, Ozaki Norio, Kato Tadalunii, Takeda Masatoshi, Kunugi Hiroshi, Koyama Tsukasa

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   Vol. 32 ( 1 ) page: 204-208   2008.1

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    DOI: 10.1016/j.pnpbp.2007.08.010

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  457. Alpha4 and Beta2 Subunits of Neuronal Nicotinic Acetylcholine Receptor Genes Are Not Associated with Methamphetamine-Use Disorder in the Japanese Population Reviewed

    Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Inada Toshiya, Harano Mutsuo, Komiyama Tokutaro, Hori Toru, Yamada Mitsuhiko, Iyo Masaomi, Sora Ichiro, Sekine Yoshimoto, Ozaki Norio, Ujike Hiroshi, Iwata Nakao

    DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES   Vol. 1139   page: 70-82   2008

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    DOI: 10.1196/annals.1432.023

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  458. Association Study between Casein Kinase 1 Epsilon Gene and Methamphetamine Dependence Reviewed

    Kotaka T., Ujike H., Morita Y., Kishimoto M., Okahisa Y., Inada T., Harano M., Komiyama T., Hori T., Yamada M., Sekine Y., Iwata N., Iyo M., Sora I., Ozaki N., Kuroda S.

    DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES   Vol. 1139   page: 43-48   2008

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    DOI: 10.1196/annals.1432.025

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  459. Changes in brain tryptophan metabolism elicited by ageing, social environment, and psychological stress in mice Reviewed

    Miura Hideki, Ozaki Norio, Shirokawa Tetsuya, Isobe Kenichi

    STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS   Vol. 11 ( 2 ) page: 160-169   2008

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    DOI: 10.1080/10253890701685908

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  460. Association analysis of the Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 (PTPRZ1) Gene with Schizophrenia in Japanese Population Reviewed

    Yamada Shinnosuke, Ito Yoshihito, Yoshimi Akira, Noda Yukihiro, Ozaki Norio

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   Vol. 128   page: 87-87   2008

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  461. Association Study of the Calcineurin A Gamma Subunit Gene (PPP3CC) and Methamphetamine-Use Disorder in a Japanese Population A Collaborative Study by the Japanese Genetics Initiative for Drug Abuse Reviewed

    Kinoshita Y., Ikeda M., Ujike H., Kitajima T., Yamanouchi Y., Aleksic B., Kishi T., Kawashima K., Ohkouchi T., Ozaki N., Inada T., Harano M., Komiyama T., Hori T., Yamada M., Sekine Y., Iyo M., Sora I., Iwata N.

    DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES   Vol. 1139   page: 57-62   2008

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    DOI: 10.1196/annals.1432.021

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  462. Comparison of sleep-disordered breathing and heart rate variability between hemodialysis and non-hemodialysis days in hemodialysis patients.

    Sukegawa M, Noda A, Soga T, Adachi Y, Tsuruta Y, Ozaki N, Koike Y

    Nagoya J Med Sci   Vol. 70 ( 3-4 ) page: 83-8   2008

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  463. Gap junction, bipolar disorder and schizophrenia: Genetic association study Reviewed

    Aleksic Branko, Ikeda Masashi, Ishihara Ryoko, Takahashi Nagahide, Saito Sinichi, Matsumoto Atsushi, Inada Toshiya, Idaka Tetsuya, Iwata Nakao, Ozaki Norio

    NEUROSCIENCE RESEARCH   Vol. 61   page: S219-S219   2008

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  464. Glutamate Cysteine Ligase Modifier (GCLM) Subunit Gene Is Not Associated with Methamphetamine-Use Disorder or Schizophrenia in the Japanese Population Reviewed

    Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Inada Toshiya, Harano Mutsuo, Komiyama Tokutaro, Horie Toru, Yamada Mitsuhiko, Iyo Masaomi, Sora Ichiro, Sekine Yoshimoto, Ozaki Norio, Ujike Hiroshi, Iwata Nakao

    DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES   Vol. 1139   page: 63-69   2008

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    DOI: 10.1196/annals.1432.022

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  465. Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder Reviewed

    Yoshimi Akira, Noda Yukihiro, Yamada Kiyofumi, Ozaki Norio

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   Vol. 128   page: 88-88   2008

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  466. Prostate Apoptosis Response 4 Gene Is Not Associated with Methamphetamine-Use Disorder in the Japanese Population Reviewed

    Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Inada Toshiya, Harano Mutsuo, Komiyama Tokutaro, Hori Toru, Yamada Mitsuhiko, Iyo Masaomi, Sora Ichiro, Sekine Yoshimoto, Ozaki Norio, Ujike Hiroshi, Iwata Nakao

    DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES   Vol. 1139   page: 83-88   2008

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    DOI: 10.1196/annals.1432.024

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  467. The functional roles of "shati' in the dependence on methamphetamine (METH) Reviewed

    Niwa Minae, Nitta Atsumi, Mizoguchi Hiroyuki, Itoh Yasutomo, Noda Yukihiro, Nagai Taku, Ozaki Norio, Nabeshima Toshitaka

    NEUROSCIENCE RESEARCH   Vol. 61   page: S271-S271   2008

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  468. An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population.

    Ji X, Takahashi N, Branko A, Ishihara R, Nagai T, Mouri A, Saito S, Maeno N, Inada T, Ozaki N

    Nagoya J Med Sci   Vol. 70 ( 1-2 ) page: 11-7   2008

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  469. The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats Reviewed

    Nakayama Hironao, Kitaichi Kiyoyuki, Ito Yukiko, Hashimotoa Katsunori, Takagi Kenji, Yokoi Toyoharu, Takagi Kenzo, Ozaki Norio, Yamamoto Tuneyuki, Hasegawa Takaaki

    BRAIN RESEARCH   Vol. 1184   page: 260-269   2007.12

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    DOI: 10.1016/j.brainres.2007.09.072

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  470. Age of onset has limited association with body mass index at time of presentation for anorexia nervosa: Comparison of peak-onset and late-onset anorexia nervosa groups Reviewed

    Kimura Hiroyuki, Tonoike Takashi, Muroya Tamio, Yoshida Keizo, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 61 ( 6 ) page: 646-650   2007.12

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    DOI: 10.1111/j.1440-1819.2007.01719.x

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  471. Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia Reviewed

    Hashimoto R., Hashimoto H., Shintani N., Chiba S., Hattori S., Okada T., Nakajima M., Tanaka K., Kawagishi N., Nemoto K., Mori T., Ohnishi T., Noguchi H., Hori H., Suzuki T., Iwata N., Ozaki N., Nakabayashi T., Saitoh O., Kosuga A., Tatsumi M., Kamijima K., Weinberger D. R., Kunugi H., Baba A.

    MOLECULAR PSYCHIATRY   Vol. 12 ( 11 ) page: 1026-1032   2007.11

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    DOI: 10.1038/sj.mp.4001982

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  472. Support for association of the PPP3CC gene with schizophrenia Reviewed

    Horiuchi Y., Ishiguro H., Koga M., Inada T., Iwata N., Ozaki N., Ujike H., Muratake T., Someya T., Arinami T.

    MOLECULAR PSYCHIATRY   Vol. 12 ( 10 ) page: 891-893   2007.10

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    DOI: 10.1038/sj.mp.4002019

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  473. The new GRID Hamilton Rating Scale for depression demonstrates excellent inter-rater reliability for inexperienced and experienced raters before and after training Reviewed

    Tabuse Hideaki, Kalali Amir, Azuma Hideki, Ozaki Norio, Iwata Nakao, Naitoh Hiroshi, Higuchi Teruhiko, Kanba Shigenobu, Shioe Kunihiko, Akechi Tatsuo, Furukawa Toshi A.

    PSYCHIATRY RESEARCH   Vol. 153 ( 1 ) page: 61-67   2007.9

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    DOI: 10.1016/j.psychres.2006.07.004

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  474. Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice Reviewed

    Miura Hideki, Kitagami Tomitsune, Ozaki Norio

    SYNAPSE   Vol. 61 ( 9 ) page: 698-706   2007.9

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    DOI: 10.1002/syn.20407

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  475. Gene variants of dopamine receptors as predictors of response to risperidone treatment in first-episode schizophrenia patients Reviewed

    Yamanouchi Yoshio, Ikeda Masashi, Yoshimura Reiji, Hashimoto Shuji, Nakamura Jun, Ozaki Norio, Iwata Nakao

    INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY   Vol. 22 ( 5 ) page: A3-A3   2007.9

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  476. A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription Reviewed

    Ohnishi Tetsuo, Yamada Kazuo, Ohba Hisako, Iwayama Yoshimi, Toyota Tomoko, Hattori Eiji, Inada Toshiya, Kunugi Hiroshi, Tatsumi Masahiko, Ozaki Norio, Iwata Nakao, Sakamoto Kaoru, Iijima Yoshimi, Iwata Yasuhide, Tsuchiya Kenji J., Sugihara Genichi, Nanko Shinichiro, Osumi Noriko, Detera-Wadleigh Sevilla D., Kato Tadafumi, Yoshikawa Takeo

    NEUROPSYCHOPHARMACOLOGY   Vol. 32 ( 8 ) page: 1727-1737   2007.8

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    DOI: 10.1038/sj.npp.1301307

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  477. Association of SOX10 with schizophrenia in the Japanese population Reviewed

    Maeno Nobuhisa, Takahashi Nagahide, Saito Shinichi, Ji Xiaofei, Ishihara Ryoko, Aoyama Nagisa, Branko Aleksic, Miura Hideki, Ikeda Masashi, Suzuki Tatsuyo, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Iwata Nakao, Inada Toshiya, Ozaki Norio

    PSYCHIATRIC GENETICS   Vol. 17 ( 4 ) page: 227-231   2007.8

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  478. The G196A polymorphism of the brain-derived neurotrophic factor gene and the antidepressant effect of milnacipran and fluvoxamine Reviewed

    Yoshida Keizo, Higuchi Hisashi, Kamata Mitsuhiro, Takahashi Hitoshi, Inoue Kazuyuki, Suzuki Toshio, Roh Kunihiko, Ozaki Norio

    JOURNAL OF PSYCHOPHARMACOLOGY   Vol. 21 ( 6 ) page: 650-656   2007.8

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    DOI: 10.1177/0269881106072192

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  479. P2X(3) receptor mediates heat hyperalgesia in a rat model of trigeminal neuropathic pain Reviewed

    Shinoda Masamichl, Kawashima Kiyohito, Ozaki Noriyuki, Asai Hideaki, Nagamine Kenjiro, Sugiura Yasuo

    JOURNAL OF PAIN   Vol. 8 ( 7 ) page: 588-597   2007.7

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    DOI: 10.1016/j.jpain.2007.03.001

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  480. Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis Reviewed

    Matsuzawa Daisuke, Hashimoto Kenji, Miyatake Ryosuke, Shirayama Yukihiko, Shimizu Eiji, Maeda Kazuhisa, Suzuki Yoichi, Mashimo Yoichi, Sekine Yoshimoto, Inada Toshiya, Ozaki Norio, Iwata Nakao, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Sora Ichiro, Ujike Hiroshi, Hata Akira, Sawa Akira, Iyo Masaomi

    AMERICAN JOURNAL OF PSYCHIATRY   Vol. 164 ( 7 ) page: 1105-1114   2007.7

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  481. The aggressive behavior of autistic patients. Some general considerations Reviewed

    Muraru Oana, Honjo Shuji, Murase Satomi, Kaneko Hitoshi, Nomura Kenji, Ishii Takashi, Koishi Seiji, Ishikawa Naoko, Ozaki Norio

    ROMANIAN JOURNAL OF LEGAL MEDICINE   Vol. 15 ( 2 ) page: 127-134   2007.6

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  482. Gap junction coding genes and schizophrenia: a genetic association study Reviewed

    Aleksic Branko, Ishihara Ryoko, Takahashi Nagahide, Maeno Nobuhisa, Ji Xiaofei, Saito Shinichi, Inada Toshiya, Ozaki Norio

    JOURNAL OF HUMAN GENETICS   Vol. 52 ( 6 ) page: 498-501   2007.6

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    DOI: 10.1007/s10038-007-0142-5

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  483. PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: Association study in a large case-control population Reviewed

    Ishiguro H., Koga M., Horiuchi Y., Inada T., Iwata N., Ozaki N., Ujike H., Muratake T., Someya T., Arinami T.

    NEUROSCIENCE RESEARCH   Vol. 58 ( 2 ) page: 145-148   2007.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neures.2007.02.008

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  484. Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population Reviewed

    Koga Minori, Ishiguro Hiroki, Horiuchi Yasue, Albalushi Talal, Inada Toshiya, Iwata Nakao, Ozaki Norio, Ujike Hiroshi, Muratake Tatsuyuki, Someya Toshiyuki, Arinami Tadao

    NEUROSCIENCE LETTERS   Vol. 417 ( 3 ) page: 326-329   2007.5

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    DOI: 10.1016/j.neulet.2007.02.055

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  485. No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population Reviewed

    Ikeda Masashi, Ozaki Norio, Yamanouchi Yoshio, Suzuki Tatsuyo, Kitajima Tsuyoshi, Kinoshita Yoko, Inada Toshiya, Iwata Nakao

    BIOLOGICAL PSYCHIATRY   Vol. 61 ( 8 ) page: 206S-207S   2007.4

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  486. Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia Reviewed

    Deng Xiangdong, Shibata Hiroki, Takeuchi Naoko, Rachi Shinako, Sakai Mayumi, Ninomiya Hideaki, Iwata Nakao, Ozaki Norio, Fukumaki Yasuyuki

    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS   Vol. 144B ( 3 ) page: 271-278   2007.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ajmg.b.30351

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  487. Characterization of seizure-prone phenotype in Pten mutant mice Reviewed

    Ogawa S., Kwon C. H., Parada L. F., Ozaki N., Sinton C. M.

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 61 ( 2 ) page: S9-S9   2007.4

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  488. Association study between Apolipoprotein L and schizophrenia by exhaustive and rule-based combination analysis for identification of multilocus interactions Reviewed

    Tomita Yasuyuki, Ikeda Masashi, Mutoh Hironori, Inada Toshiya, Iwata Nakao, Ozaki Norio, Honda Hiroyuki

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   Vol. 103 ( 4 ) page: 303-310   2007.4

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    DOI: 10.1263/jbb.103.303

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  489. Association study between the transferrin gene and schizophrenia in the Japanese population Reviewed

    Maeno Nobuhisa, Takahashi Nagahide, Saito Shinichi, Ji Xiaofei, Branko Aleksic, Ishihara Ryoko, Yoshida Keizo, Inada Toshiya, Iidaka Tetsuya, Ozaki Norio

    NEUROREPORT   Vol. 18 ( 5 ) page: 517-520   2007.3

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