Faculty Profiles - OZAKI Norio

Nagoya University Graduate School of Medicine Pathophysiology of Mental Disorders Designated professor

2022.4

　 More details

Country：Japan
東海国立大学機構糖鎖生命コア研究所特任教授

2021.1

　 More details

Country：Japan
名古屋大学大学院医学系研究科精神医学分野・親と子どもの心療学分野教授、同病院精神科・親と子どもの心療科科長、2018年:同病院ゲノム医療センター長、遺伝カウンセリング部門長、2019年:同大学脳とこころの研究センター長

2003.10 - 2022.3

　 More details

Country：Japan
藤田保健衛生大学医学部精神医学教室教授

1998.5 - 2003.9

　 More details

Country：Japan
藤田保健衛生大学医学部精神医学教室講師

1995.9 - 1998.4

　 More details

Country：Japan
米国National Institute of Mental Health, Visiting Fellow

1990.7 - 1995.8

　 More details

Country：Japan
中部労災病院精神科医師

1987.7 - 1990.6

　 More details

Country：Japan
名古屋大学精神科医員

1984.4 - 1987.6

　 More details

Country：Japan
中京病院研修医

1982.5 - 1984.3

　 More details

Country：Japan
Nagoya University School of Medicine

1982

▼display all

To the head of Research History.▲

Education 1

Nagoya University Faculty of Medicine

- 1982

　 More details

Country： Japan

To the head of Education.▲

Professional Memberships 12

World Federation of Biological Psychiatry Executive Member(2005-2009)
日本精神神経学会理事
日本うつ病学会理事(前理事長)
日本統合失調症学会理事
日本うつ病リワーク協会　理事
日本生物学的精神医学会評議員(前理事長)
日本神経精神薬理学会評議員
日本臨床精神神経薬理学会評議員
日本人類遺伝学会評議員
日本睡眠学会評議員
日本脳科学関連学会連合産学連携諮問委員会健康医療戦略検討グループ長(前副代表)
日本医学会「遺伝子・健康・社会」検討委員会委員　など

▼display all

To the head of Professional Memberships.▲

Papers 648

Neuropathological substrate of incident dementia in older patients with schizophrenia: A clinicopathological study.

Arafuka S, Fujishiro H, Torii Y, Sekiguchi H, Habuchi C, Miwa A, Yoshida M, Iritani S, Iwasaki Y, Ikeda M, Ozaki N

Psychiatry and clinical neurosciences 2023.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.13597

PubMed
Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals

Junya Matsumoto, Masaki Fukunaga, Kenichiro Miura, Kiyotaka Nemoto, Naohiro Okada, Naoki Hashimoto, Kentaro Morita, Daisuke Koshiyama, Kazutaka Ohi, Tsutomu Takahashi, Michihiko Koeda, Hidenaga Yamamori, Michiko Fujimoto, Yuka Yasuda, Satsuki Ito, Ryuichi Yamazaki, Naomi Hasegawa, Hisashi Narita, Satoshi Yokoyama, Ryo Mishima, Jun Miyata, Yuko Kobayashi, Daiki Sasabayashi, Kenichiro Harada, Maeri Yamamoto, Yoji Hirano, Takashi Itahashi, Masahito Nakataki, Ryu-ichiro Hashimoto, Khin K. Tha, Shinsuke Koike, Toshio Matsubara, Go Okada, Reiji Yoshimura, Osamu Abe, Theo G. M. van Erp, Jessica A. Turner, Neda Jahanshad, Paul M. Thompson, Toshiaki Onitsuka, Yoshiyuki Watanabe, Koji Matsuo, Hidenori Yamasue, Yasumasa Okamoto, Michio Suzuki, Norio Ozaki, Kiyoto Kasai, Ryota Hashimoto

Molecular Psychiatry 2023.8

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), and autism spectrum disorder (ASD) are classified based on symptoms. While its cluster of symptoms defines each of these psychiatric disorders, there is also an overlap in symptoms between the disorders. We hypothesized that there are also similarities and differences in cortical structural neuroimaging features among these psychiatric disorders. T1-weighted magnetic resonance imaging scans were performed for 5,549 subjects recruited from 14 sites. Effect sizes were determined using a linear regression model within each protocol, and these effect sizes were meta-analyzed. The similarity of the differences in cortical thickness and surface area of each disorder group was calculated using cosine similarity, which was calculated from the effect sizes of each cortical regions. The thinnest cortex was found in SZ, followed by BD and MDD. The cosine similarity values between disorders were 0.943 for SZ and BD, 0.959 for SZ and MDD, and 0.943 for BD and MDD, which indicated that a common pattern of cortical thickness alterations was found among SZ, BD, and MDD. Additionally, a generally smaller cortical surface area was found in SZ and MDD than in BD, and the effect was larger in SZ. The cosine similarity values between disorders were 0.945 for SZ and MDD, 0.867 for SZ and ASD, and 0.811 for MDD and ASD, which indicated a common pattern of cortical surface area alterations among SZ, MDD, and ASD. Patterns of alterations in cortical thickness and surface area were revealed in the four major psychiatric disorders. To our knowledge, this is the first report of a cross-disorder analysis conducted on four major psychiatric disorders. Cross-disorder brain imaging research can help to advance our understanding of the pathogenesis of psychiatric disorders and common symptoms.

DOI： 10.1038/s41380-023-02224-7

PubMed

Other Link： https://www.nature.com/articles/s41380-023-02224-7
Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification

Okada Naohiro, Fukunaga Masaki, Miura Kenichiro, Nemoto Kiyotaka, Matsumoto Junya, Hashimoto Naoki, Kiyota Masahiro, Morita Kentaro, Koshiyama Daisuke, Ohi Kazutaka, Takahashi Tsutomu, Koeda Michihiko, Yamamori Hidenaga, Fujimoto Michiko, Yasuda Yuka, Hasegawa Naomi, Narita Hisashi, Yokoyama Satoshi, Mishima Ryo, Kawashima Takahiko, Kobayashi Yuko, Sasabayashi Daiki, Harada Kenichiro, Yamamoto Maeri, Hirano Yoji, Itahashi Takashi, Nakataki Masahito, Hashimoto Ryu-ichiro, Tha Khin K., Koike Shinsuke, Matsubara Toshio, Okada Go, van Erp Theo G. M., Jahanshad Neda, Yoshimura Reiji, Abe Osamu, Onitsuka Toshiaki, Watanabe Yoshiyuki, Matsuo Koji, Yamasue Hidenori, Okamoto Yasumasa, Suzuki Michio, Turner Jessica A., Thompson Paul M., Ozaki Norio, Kasai Kiyoto, Hashimoto Ryota

MOLECULAR PSYCHIATRY 2023.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41380-023-02141-9

Web of Science

PubMed
Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia. International journal

Jingzhu Liao, Geyao Dong, Wenjun Zhu, Bolati Wulaer, Hiroyuki Mizoguchi, Masahito Sawahata, Yue Liu, Kozo Kaibuchi, Norio Ozaki, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada

Pharmacological research Vol. 194 page： 106838 - 106838 2023.8

　More details

Language：English Publishing type：Research paper (scientific journal)

Schizophrenia (SCZ) is a severe psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive deficits. Current antipsychotic treatment in SCZ improves positive symptoms but has major side effects and little impact on negative symptoms and cognitive impairment. The pathoetiology of SCZ remains unclear, but is known to involve small GTPase signaling. Rho kinase, an effector of small GTPase Rho, is highly expressed in the brain and plays a major role in neurite elongation and neuronal architecture. This study used a touchscreen-based visual discrimination (VD) task to investigate the effects of Rho kinase inhibitors on cognitive impairment in a methamphetamine (METH)-treated male mouse model of SCZ. Systemic injection of the Rho kinase inhibitor fasudil dose-dependently ameliorated METH-induced VD impairment. Fasudil also significantly suppressed the increase in the number of c-Fos-positive cells in the infralimbic medial prefrontal cortex (infralimbic mPFC) and dorsomedial striatum (DMS) following METH treatment. Bilateral microinjections of Y-27632, another Rho kinase inhibitor, into the infralimbic mPFC or DMS significantly ameliorated METH-induced VD impairment. Two proteins downstream of Rho kinase, myosin phosphatase-targeting subunit 1 (MYPT1; Thr696) and myosin light chain kinase 2 (MLC2; Thr18/Ser19), exhibited increased phosphorylation in the infralimbic mPFC and DMS, respectively, after METH treatment, and fasudil inhibited these increases. Oral administration of haloperidol and fasudil ameliorated METH-induced VD impairment, while clozapine had little effect. Oral administration of haloperidol and clozapine suppressed METH-induced hyperactivity, but fasudil had no effect. These results suggest that METH activates Rho kinase in the infralimbic mPFC and DMS, which leads to cognitive impairment in male mice. Rho kinase inhibitors ameliorate METH-induced cognitive impairment, perhaps via the cortico-striatal circuit.

DOI： 10.1016/j.phrs.2023.106838

Web of Science

PubMed
Evaluating sleep-wake rhythm using a wearable device in patients with mental disorders. International journal

Seiko Miyata, Kunihiro Iwamoto, Norio Ozaki

Psychiatry and clinical neurosciences Vol. 77 ( 8 ) page： 419 - 419 2023.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.13568

Web of Science

PubMed
Feasibility of a wrist-worn wearable device for estimating mental health status in patients with mental illness

Nakagome Kazuyuki, Makinodan Manabu, Uratani Mitsuhiro, Kato Masaki, Ozaki Norio, Miyata Seiko, Iwamoto Kunihiro, Hashimoto Naoki, Toyomaki Atsuhito, Mishima Kazuo, Ogasawara Masaya, Takeshima Masahiro, Minato Kazumichi, Fukami Toshikazu, Oba Mari, Takeda Kazuyoshi, Oi Hideki

FRONTIERS IN PSYCHIATRY Vol. 14 page： 1189765 2023.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3389/fpsyt.2023.1189765

Web of Science

PubMed
Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder

Amare Azmeraw T., Thalamuthu Anbupalam, Schubert Klaus Oliver, Fullerton Janice M., Ahmed Muktar, Hartmann Simon, Papiol Sergi, Heilbronner Urs, Degenhardt Franziska, Tekola-Ayele Fasil, Hou Liping, Hsu Yi-Hsiang, Shekhtman Tatyana, Adli Mazda, Akula Nirmala, Akiyama Kazufumi, Ardau Raffaella, Arias Barbara, Aubry Jean-Michel, Hasler Roland, Richard-Lepouriel Helene, Perroud Nader, Backlund Lena, Bhattacharjee Abesh Kumar, Bellivier Frank, Benabarre Antonio, Bengesser Susanne, Biernacka Joanna M., Birner Armin, Marie-Claire Cynthia, Cervantes Pablo, Chen Hsi-Chung, Chillotti Caterina, Cichon Sven, Cruceanu Cristiana, Czerski Piotr M., Dalkner Nina, Del Zompo Maria, DePaulo J. Raymond, etain Bruno, Jamain Stephane, Falkai Peter, Forstner Andreas J., Frisen Louise, Frye Mark A., Gard Sebastien, Garnham Julie S., Goes Fernando S., Grigoroiu-Serbanescu Maria, Fallgatter Andreas J., Stegmaier Sophia, Ethofer Thomas, Biere Silvia, Petrova Kristiyana, Schuster Ceylan, Adorjan Kristina, Budde Monika, Heilbronner Maria, Kalman Janos L., Kohshour Mojtaba Oraki, Reich-Erkelenz Daniela, Schaupp Sabrina K., Schulte Eva C., Senner Fanny, Vogl Thomas, Anghelescu Ion-George, Arolt Volker, Dannlowski Udo, Dietrich Detlef, Figge Christian, Jaeger Markus, Lang Fabian U., Juckel Georg, Konrad Carsten, Reimer Jens, Schmauss Max, Schmitt Andrea, Spitzer Carsten, von Hagen Martin, Wiltfang Jens, Zimmermann Joerg, Andlauer Till F. M., Fischer Andre, Bermpohl Felix, Ritter Philipp, Matura Silke, Gryaznova Anna, Falkenberg Irina, Yildiz Cueneyt, Kircher Tilo, Schmidt Julia, Koch Marius, Gade Kathrin, Trost Sarah, Haussleiter Ida S., Lambert Martin, Rohenkohl Anja C., Kraft Vivien, Grof Paul, Hashimoto Ryota, Hauser Joanna, Herms Stefan, Hoffmann Per, Jimenez Esther, Kahn Jean-Pierre, Kassem Layla, Kuo Po-Hsiu, Kato Tadafumi, Kelsoe John, Kittel-Schneider Sarah, Ferensztajn-Rochowiak Ewa, Koenig Barbara, Kusumi Ichiro, Laje Gonzalo, Landen Mikael, Lavebratt Catharina, Leboyer Marion, Leckband Susan G., Tortorella Alfonso, Manchia Mirko, Martinsson Lina, McCarthy Michael J., McElroy Susan, Colom Francesc, Millischer Vincent, Mitjans Marina, Mondimore Francis M., Monteleone Palmiero, Nievergelt Caroline M., Noethen Markus M., Novak Tomas, O'Donovan Claire, Ozaki Norio, Pfennig Andrea, Pisanu Claudia, Potash James B., Reif Andreas, Reininghaus Eva, Rouleau Guy A., Rybakowski Janusz K., Schalling Martin, Schofield Peter R., Schweizer Barbara W., Severino Giovanni, Shilling Paul D., Shimoda Katzutaka, Simhandl Christian, Slaney Claire M., Squassina Alessio, Stamm Thomas, Stopkova Pavla, Maj Mario, Turecki Gustavo, Vieta Eduard, Veeh Julia, Witt Stephanie H., Wright Adam, Zandi Peter P., Mitchell Philip B., Bauer Michael, Alda Martin, Rietschel Marcella, McMahon Francis J., Schulze Thomas G., Clark Scott R., Baune Bernhard T.

MOLECULAR PSYCHIATRY 2023.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41380-023-02149-1

Web of Science

PubMed
Neuropsychopharmacology renaissance in Japan: A new era after the crisis

Ozaki Norio, Kimura Teiji, Kikuchi Tetsuro, Ishiyama Takeo

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 77 ( 7 ) page： 375 - 376 2023.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.13549

Web of Science

PubMed
4大精神疾患の大脳構造の類似度の解析大脳皮質厚と大脳皮質表面積の多施設共同疾患横断解析

松本純弥, 福永雅喜, 三浦健一郎, 根本清貴, 岡田直大, 橋本直樹, 森田健太郎, 越山太輔, 大井一高, 高橋努, 肥田道彦, 山森英長, 藤本美智子, 安田由華, 伊藤颯姫, 山崎龍一, 長谷川尚美, 成田尚, 横山仁史, 三嶋亮, 宮田淳, 小林祐子, 笹林大樹, 原田健一郎, 山本真江里, 平野羊嗣, 板橋貴史, 中瀧理仁, 橋本龍一郎, タ・キンキン, 小池進介, 松原敏郎, 岡田剛, 吉村玲児, 阿部修, 鬼塚俊明, 渡邊嘉之, 松尾幸治, 山末英典, 岡本泰昌, 鈴木道雄, 尾崎紀夫, 笠井清登, 橋本亮太

国立精神・神経医療研究センター精神保健研究所年報 ( 36 ) page： 210 - 210 2023.7

　More details

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(国研)国立精神・神経医療研究センター精神保健研究所
Interaction of genetic liability for attention deficit hyperactivity disorder (ADHD) and perinatal inflammation contributes to ADHD symptoms in children Reviewed

Nagahide Takahashi, Tomoko Nishimura, Taeko Harada, Akemi Okumura, Toshiki Iwabuchi, Md Shafiur Rahman, Hitoshi Kuwabara, Shu Takagai, Noriyoshi Usui, Manabu Makinodan, Hideo Matsuzaki, Norio Ozaki, Hiroaki Itoh, Yoko Nomura, Jeffrey H. Newcorn, Kenji J. Tsuchiya

Brain, Behavior, & Immunity - Health Vol. 30 page： 100630 - 100630 2023.7

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.bbih.2023.100630

Web of Science

PubMed
Structural aging of human neurons is opposite of the changes in schizophrenia. International journal

Ryuta Mizutani, Rino Saiga, Yoshiro Yamamoto, Masayuki Uesugi, Akihisa Takeuchi, Kentaro Uesugi, Yasuko Terada, Yoshio Suzuki, Vincent De Andrade, Francesco De Carlo, Susumu Takekoshi, Chie Inomoto, Naoya Nakamura, Youta Torii, Itaru Kushima, Shuji Iritani, Norio Ozaki, Kenichi Oshima, Masanari Itokawa, Makoto Arai

PloS one Vol. 18 ( 6 ) page： e0287646 2023.6

　More details

Language：English Publishing type：Research paper (scientific journal)

Human mentality develops with age and is altered in psychiatric disorders, though their underlying mechanism is unknown. In this study, we analyzed nanometer-scale three-dimensional structures of brain tissues of the anterior cingulate cortex from eight schizophrenia and eight control cases. The distribution profiles of neurite curvature of the control cases showed a trend depending on their age, resulting in an age-correlated decrease in the standard deviation of neurite curvature (Pearson's r = -0.80, p = 0.018). In contrast to the control cases, the schizophrenia cases deviate upward from this correlation, exhibiting a 60% higher neurite curvature compared with the controls (p = 7.8 × 10-4). The neurite curvature also showed a correlation with a hallucination score (Pearson's r = 0.80, p = 1.8 × 10-4), indicating that neurite structure is relevant to brain function. This report is based on our 3D analysis of human brain tissues over a decade and is unprecedented in terms of the number of cases. We suggest that neurite curvature plays a pivotal role in brain aging and can be used as a hallmark to exploit a novel treatment of schizophrenia.

DOI： 10.1371/journal.pone.0287646

Web of Science

PubMed
Case reports of two siblings with autism spectrum disorder and 15q13.3 deletions

Furukawa Sawako, Kushima Itaru, Aleksic Branko, Ozaki Norio

NEUROPSYCHOPHARMACOLOGY REPORTS Vol. 43 ( 3 ) page： 462 - 466 2023.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/npr2.12340

Web of Science

PubMed
【精神疾患レジストリによって何がわかるか?】血液由来試料の解析と縦断データに基づく,精神疾患の治療効果および予後に関する層別化

中村真理子, 吉見陽, 野田幸裕, 尾崎紀夫

精神科 Vol. 42 ( 6 ) page： 726 - 737 2023.6

　More details

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(有)科学評論社
Clinical characterization of patients with schizophrenia and 16p13.11 duplication: A case series. International journal

Hiroki Kimura, Itaru Kushima, Masahiro Banno, Toshiya Inada, Akira Yoshimi, Branko Aleksic, Norio Ozaki

Neuropsychopharmacology reports Vol. 43 ( 2 ) page： 267 - 271 2023.6

　More details

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Chromosome 16p13.11 duplication is a well-known genetic risk factor for schizophrenia (SCZ) (odds ratio = 1.84). However, no case reports focusing on patients with SCZ and 16p13.11 duplication have been published. Therefore, here, we report the detailed clinical cases of four patients with SCZ and 16p13.11 duplication who were identified in our previous whole-genome copy number variant (CNV) study. CASE PRESENTATION: In the four patients with SCZ and 16p13.11 duplication detected by array comparative genomic hybridization, one patient was found to have treatment-resistant SCZ and an additional pathogenic rare CNV. Two of the four patients in this study had environmental risk factors that may have been involved in the development of SCZ. CONCLUSIONS: The results of this case series suggest that a genetic cohort study would be useful for evaluating which genetic and environmental risk factors could better explain the variable expressivity of 16p13.11 duplication. Furthermore, this work could be useful for elucidating the pathophysiology of SCZ.

DOI： 10.1002/npr2.12334

Web of Science

PubMed
The new guideline for evaluating effects of psychotropic drugs on the performance to drive a motor vehicle in Japan: Comparison with US FDA guideline. International journal

Kunihiro Iwamoto, Tetsuo Nakabayashi, Akiko Yamaguchi, Yuki Konishi, Momoe Saji, Reiji Yoshimura, Kousuke Kanemoto, Hirofumi Aoki, Masahiko Ando, Norio Ozaki

Neuropsychopharmacology reports Vol. 43 ( 2 ) page： 172 - 176 2023.6

　More details

Language：English Publishing type：Research paper (scientific journal)

In December 2022, the new guideline for evaluating the effect of psychotropic drugs on the performance to drive a motor vehicle was issued by the Ministry of Health, Labour and Welfare (MHLW) and implemented in Japan. Of the safety information, information on the influence of medications on driving performance is particularly important because it can be relevant to the social functioning of patients. In principle, the package inserts of medications are designed based on evidence and provide precautions regarding the operation of heavy machinery such as automobiles in Japan, the United States, and Europe. The effects of medications on driving performance are generally evaluated in a tiered approach involving nonclinical and clinical studies. Because of the wide variety of functional domains involved in automobile driving, the selection of evaluation methods for a given medication depends on their characteristics, which is a complicated method. Therefore, to evaluate the effects of psychotropic drugs on driving performance efficiently and appropriately, we developed the MHLW guideline that specifically defines the evaluation methods used in pharmacological studies, the neuropsychological tests used in pharmacodynamic studies, and the situations in which driving studies are necessary. Regarding the planning of appropriate drug development strategies, we review the background of the MHLW guideline and its differences from the US Food and Drug Administration (FDA) guideline.

DOI： 10.1002/npr2.12339

Web of Science

PubMed
LONG-TERM EFFICACY OF LEMBOREXANT ON OBJECTIVE SLEEP MEASURES IN CLINICAL PRACTICE

Miyata Seiko, Iwamoto Kunihiro, Okada Ippei, Fujimoto Akihiro, Kogo Yuki, Amano Manabu, Matsuyama Nao, Ozaki Norio

SLEEP Vol. 46 2023.5

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
[How to Use Psychotropic Drugs During the Perinatal Period: Risks and Benefits for Fetuses and Infants].

Wada S, Ogasawara K, Ozaki N

Brain and nerve = Shinkei kenkyu no shinpo Vol. 75 ( 5 ) page： 645 - 651 2023.5

　More details

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.11477/mf.1416202392

PubMed
Histological Analysis of a Mouse Model of the 22q11.2 Microdeletion Syndrome

Tabata Hidenori, Mori Daisuke, Matsuki Tohru, Yoshizaki Kaichi, Asai Masato, Nakayama Atsuo, Ozaki Norio, Nagata Koh-ichi

BIOMOLECULES Vol. 13 ( 5 ) 2023.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3390/biom13050763

Web of Science

PubMed
Comorbid psychiatric disorders and long-term survival after liver transplantation in transplant facilities with a psychiatric consultation-liaison team: a multicenter retrospective study

Kimura Hiroyuki, Kishi Shinichi, Narita Hisashi, Tanaka Teruaki, Okada Tsuyoshi, Fujisawa Daisuke, Sugita Naoko, Noma Shun'ichi, Matsumoto Yosuke, Ohashi Ayako, Mitsuyasu Hiroshi, Yoshida Keizo, Kawasaki Hiroaki, Nishimura Katsuji, Ogura Yasuhiro, Ozaki Norio

BMC GASTROENTEROLOGY Vol. 23 ( 1 ) page： 106 2023.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s12876-023-02735-1

Web of Science

PubMed
Molecular diagnosis of 405 individuals with autism spectrum disorder. International journal

Noriko Miyake, Yoshinori Tsurusaki, Ryoko Fukai, Itaru Kushima, Nobuhiko Okamoto, Kei Ohashi, Kazuhiko Nakamura, Ryota Hashimoto, Yoko Hiraki, Shuraku Son, Mitsuhiro Kato, Yasunari Sakai, Hitoshi Osaka, Kimiko Deguchi, Toyojiro Matsuishi, Saoko Takeshita, Aviva Fattal-Valevski, Nina Ekhilevitch, Jun Tohyama, Patrick Yap, Wee Teik Keng, Hiroshi Kobayashi, Keiyo Takubo, Takashi Okada, Shinji Saitoh, Yuka Yasuda, Toshiya Murai, Kazuyuki Nakamura, Shouichi Ohga, Ayumi Matsumoto, Ken Inoue, Tomoko Saikusa, Tova Hershkovitz, Yu Kobayashi, Mako Morikawa, Aiko Ito, Toshiro Hara, Yota Uno, Chizuru Seiwa, Kanako Ishizuka, Emi Shirahata, Atsushi Fujita, Eriko Koshimizu, Satoko Miyatake, Atsushi Takata, Takeshi Mizuguchi, Norio Ozaki, Naomichi Matsumoto

European journal of human genetics : EJHG 2023.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Autism spectrum disorder (ASD) is caused by combined genetic and environmental factors. Genetic heritability in ASD is estimated as 60-90%, and genetic investigations have revealed many monogenic factors. We analyzed 405 patients with ASD using family-based exome sequencing to detect disease-causing single-nucleotide variants (SNVs), small insertions and deletions (indels), and copy number variations (CNVs) for molecular diagnoses. All candidate variants were validated by Sanger sequencing or quantitative polymerase chain reaction and were evaluated using the American College of Medical Genetics and Genomics/Association for Molecular Pathology guidelines for molecular diagnosis. We identified 55 disease-causing SNVs/indels in 53 affected individuals and 13 disease-causing CNVs in 13 affected individuals, achieving a molecular diagnosis in 66 of 405 affected individuals (16.3%). Among the 55 disease-causing SNVs/indels, 51 occurred de novo, 2 were compound heterozygous (in one patient), and 2 were X-linked hemizygous variants inherited from unaffected mothers. The molecular diagnosis rate in females was significantly higher than that in males. We analyzed affected sibling cases of 24 quads and 2 quintets, but only one pair of siblings shared an identical pathogenic variant. Notably, there was a higher molecular diagnostic rate in simplex cases than in multiplex families. Our simulation indicated that the diagnostic yield is increasing by 0.63% (range 0-2.5%) per year. Based on our simple simulation, diagnostic yield is improving over time. Thus, periodical reevaluation of ES data should be strongly encouraged in undiagnosed ASD patients.

DOI： 10.1038/s41431-023-01335-7

PubMed
Shedding light on latent pathogenesis and pathophysiology of mental disorders: the potential of iPS cell technology.

Arioka Y, Okumura H, Sakaguchi H, Ozaki N

Psychiatry and clinical neurosciences 2023.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.13545

PubMed
Astrotactin 2 (ASTN2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems

Ito Takahiro, Yoshida Mikio, Aida Tomomi, Kushima Itaru, Hiramatsu Yuka, Ono Maiko, Yoshimi Akira, Tanaka Kohichi, Ozaki Norio, Noda Yukihiro

JOURNAL OF NEUROCHEMISTRY 2023.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/jnc.15790

Web of Science

PubMed
Sensory evaluation of the bitterness of asenapine using D-sorbitol pretreatment: single-blind, placebo-controlled, crossover trial. International journal

Shuhei Wada, Kunihiro Iwamoto, Hiroki Okumura, Hirotake Hida, Shuichi Hiraoka, Aya Kamei, Daisuke Mori, Kiyofumi Yamada, Norio Ozaki

BMC psychiatry Vol. 23 ( 1 ) page： 159 - 159 2023.3

　More details

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Antipsychotics are essential in the acute treatment of and maintenance therapy for schizophrenia, but medication adherence and long-term treatment continuity are needed to maximize their effectiveness. Each antipsychotic has various side effects, which may affect adherence. Some patients with schizophrenia are reluctant to take asenapine because of its unique oral-related side effects, such as the bitter taste caused by sublingual administration. Our previous basic research found that D-sorbitol lowered the bitterness parameters of the taste sensors. However, whether D-sorbitol has the same effect in patients remains unclear. Therefore, using a D-sorbitol solution, we aim to evaluate changes in the bitterness of asenapine among patients with schizophrenia. METHODS: In this single-blind, placebo-controlled, crossover trial, we plan to recruit 20 adult patients with schizophrenia spectrum disorder who take sublingual asenapine tablets. The participants will be divided into two groups (n = 10 each). Each group will be given a D-sorbitol or placebo solution on the first day for rinsing before taking the sublingual asenapine tablets. After a 1-day interval, the participants will rinse their mouths again with a different liquid. Questionnaires regarding changes in taste and the willingness to continue asenapine will be conducted before the start of the study and after each rinse. The primary and secondary end points will be a taste evaluation of bitterness, and the willingness to continue asenapine, respectively. Differences in questionnaire scores between the D-sorbitol and placebo solutions will be calculated and analyzed using a McNemar test. DISCUSSION: This study aims to determine the efficacy of D-sorbitol in masking the bitter taste of asenapine. To our knowledge, it is the first intervention study using D-sorbitol for bitter taste of asenapine in patients with schizophrenia. Evidence of the efficacy of D-sorbitol could result in D-sorbitol pretreatment being an easy and inexpensive means of improving adherence to asenapine. TRIAL REGISTRATION: This study was registered in the Japan Registry of Clinical Trials jRCTs041210019, on May 14, 2021. Ethics approval was obtained from the Nagoya University Clinical Research Review Board.

DOI： 10.1186/s12888-023-04664-5

PubMed
An autopsy case of schizophrenia comorbid with argyrophilic grain disease. International journal

Youta Torii, Shuji Iritani, Hiroshige Fujishiro, Hirotaka Sekiguchi, Chikako Habuchi, Toshimasa Ikeda, Mari Yoshida, Yasushi Iwasaki, Norio Ozaki, Kunihiro Kawashima

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society Vol. 23 ( 2 ) page： 371 - 373 2023.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/psyg.12935

Web of Science

PubMed
Late-onset panic disorder as the initial presentation in autopsy-confirmed dementia with Lewy bodies. International journal

Shusei Arafuka, Hirotaka Sekiguchi, Hiroshige Fujishiro, Shuji Iritani, Youta Torii, Chikako Habuchi, Mari Yoshida, Yasushi Iwasaki, Norio Ozaki, Kiyoshi Fujita

Psychiatry and clinical neurosciences Vol. 77 ( 4 ) page： 242 - 244 2023.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.13532

Web of Science

PubMed
A case of bipolar disorder with AIF1 (coding gene of Iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells

Ohgidani Masahiro, Kushima Itaru, Inamine Shogo, Kyuragi Sota, Sagata Noriaki, Nakao Tomohiro, Kanba Shigenobu, Ozaki Norio, Kato Takahiro A.

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 77 ( 2 ) page： 128 - 130 2023.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.13505

Web of Science

PubMed
Clinical manifestations of schizophrenia in four patients with variants in voltage-gated calcium channel-encoding genes: a case series. International journal

Tzuyao Lo, Itaru Kushima, Branko Aleksic, Akira Yoshimi, Toshiyuki Someya, Yuichiro Watanabe, Norio Ozaki

Psychiatry and clinical neurosciences Vol. 77 ( 1 ) page： 57 - 59 2023.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.13494

Web of Science

PubMed
Temporal trajectories of proposed biomarkers in psychiatric-onset prodromal dementia with Lewy bodies: a case report. International journal

Hiroshige Fujishiro, Shusei Arafuka, Kazuyoshi Ogasawara, Kunihiro Iwamoto, Seiko Miyata, Youta Torii, Shuji Iritani, Norio Ozaki

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society Vol. 23 ( 1 ) page： 196 - 200 2023.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/psyg.12922

Web of Science

PubMed
Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene Reviewed

Rinako Tanaka, Jingzhu Liao, Kazuhiro Hada, Daisuke Mori, Taku Nagai, Tetsuo Matsuzaki, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroyuki Mizoguchi, Kiyofumi Yamada

Pharmacological Research Vol. 187 page： 106589 - 106589 2023.1

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.phrs.2022.106589

Web of Science

PubMed
Exploratory Validation of Sleep-Tracking Devices in Patients with Psychiatric Disorders

Ogasawara Masaya, Takeshima Masahiro, Kosaka Shumpei, Imanishi Aya, Itoh Yu, Fujiwara Dai, Yoshizawa Kazuhisa, Ozaki Norio, Nakagome Kazuyuki, Mishima Kazuo

NATURE AND SCIENCE OF SLEEP Vol. 15 page： 301 - 312 2023

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.2147/NSS.S400944

Web of Science

PubMed
Comparison of quality of life and psychological distress in patients with tongue cancer undergoing a total/subtotal glossectomy or extended hemiglossectomy and free flap transfer: a prospective evaluation

K. Suzuki, N. Nishio, H. Kimura, T. Tokura, S. Kishi, N. Ozaki, Y. Fujimoto, M. Sone

International Journal of Oral and Maxillofacial Surgery 2022.12

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.ijom.2022.11.010

PubMed
Turner syndrome presenting with idiopathic regression: A case report

Mizobuchi Kosuke, Kushima Itaru, Kato Hidekazu, Miyajima Mari, Kimura Hiroyuki, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 76 ( 12 ) page： 680 - 682 2022.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.13483

Web of Science

PubMed
Reproducibility of functional connectivity metrics estimated from resting-state functional MRI with differences in days, coils, and global signal regression

Kato Sanae, Bagarinao Epifanio, Isoda Haruo, Koyama Shuji, Watanabe Hirohisa, Maesawa Satoshi, Hara Kazuhiro, Katsuno Masahisa, Naganawa Shinji, Ozaki Norio, Sobue Gen

RADIOLOGICAL PHYSICS AND TECHNOLOGY Vol. 15 ( 4 ) page： 298 - 310 2022.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s12194-022-00670-6

Web of Science

PubMed
Prevalence of obstructive sleep apnea as assessed by polysomnography in psychiatric patients with sleep-related problems. International journal

Ippei Okada, Seiko Miyata, Kunihiro Iwamoto, Hiroshige Fujishiro, Akiko Noda, Norio Ozaki

Sleep & breathing = Schlaf & Atmung Vol. 26 ( 4 ) page： 1983 - 1991 2022.12

　More details

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Patients with psychiatric disorders often complain of sleep disturbances and are frequently suspected of obstructive sleep apnea (OSA). However, data regarding sleep problems evaluated by attended polysomnography (PSG) remain limited in this population. We analyzed the results of attended PSG from psychiatric patients with sleep-related problems to determine the prevalence and features of sleep disorders among this population. METHODS: We retrospectively investigated the attended PSG results of patients with psychiatric disorders: major depressive disorder, bipolar disorder, neurodevelopmental disorder, schizophrenia, neurocognitive disorder, anxiety disorder, somatic symptom disorder. RESULTS: Of 264 patients, 158 men (60%), mean age was 47 ± 19.9 years. More than half of the patients with major depressive disorder (62%), bipolar disorder (70%), schizophrenia (58%), neurocognitive disorders (55%), and somatic symptom disorder (56%) had OSA. Among the psychiatric patients with OSA, 62% of these patients had moderate to severe OSA. The risk factors for OSA were snoring, male, age, and body mass index. The presence of OSA was not associated with the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale score, or benzodiazepine, antipsychotic, or antidepressant use. Other sleep disorders were insomnia (19%), central disorders of hypersomnia (8%), restless legs syndrome/periodic limb movement of sleep (8%), rapid eye movement sleep behavior disorder (7%), and central sleep apnea syndrome (3%). CONCLUSIONS: PSG revealed that moderate to severe OSA was common in psychiatric patients with or without snoring. Subjective symptoms and psychotropics did not predict OSA. Therefore, PSG is needed to reveal sleep conditions in patients with psychiatric disorders.

DOI： 10.1007/s11325-022-02566-6

Web of Science

PubMed
X chromosome aneuploidies and schizophrenia: association analysis and phenotypic characterization

Itaru Kushima, Branko Aleksic, Hiroki Kimura, Masahiro Nakatochi, Tzuyao Lo, Masashi Ikeda, Makoto Arai, Ryota Hashimoto, Shusuke Numata, Yasunobu Okamura, Taku Obara, Toshiya Inada, Norio Ozaki

Psychiatry and Clinical Neurosciences Vol. 76 ( 12 ) page： 667 - 673 2022.12

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

DOI： 10.1111/pcn.13474

Web of Science

PubMed
Memantine ameliorates the impairment of social behaviors induced by a single social defeat stress as juveniles

Mikio Yoshida, Sho Hasegawa, Masayuki Taniguchi, Akihiro Mouri, Chiharu Suzuki, Akira Yoshimi, Takayoshi Mamiya, Norio Ozaki, Yukihiro Noda

Neuropharmacology Vol. 217 page： 109208 - 109208 2022.10

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.neuropharm.2022.109208

Web of Science

PubMed
Establishment of induced pluripotent stem cells from a patient with 16p13.11 duplication and VPS13B deletion

Okumura Hiroki, Arioka Yuko, Kushima Itaru, Mori Daisuke, Ozaki Norio

STEM CELL RESEARCH Vol. 64 page： 102884 2022.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.scr.2022.102884

Web of Science

PubMed
エネルギー器官としての脳組織構造と統合失調症

糸川昌成, 大島健一, 鳥海和也, 吉川茜, 堀内泰江, 宮下光弘, 宮野康寛, 石田裕昭, 小堀晶子, 井上智子, 新井誠, 鳥居洋太, 久島周, 入谷修司, 尾崎紀夫, 鈴木芳生, 野口千太, 雑賀里乃, 水谷隆太

精神神経学雑誌 Vol. 124 ( 10 ) page： 688 - 699 2022.10

　More details

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(公社)日本精神神経学会

統合失調症研究にとって脳は中心的な標的器官である.脳は重量比にして体重の50分の1程度の小さな臓器だが,膨大なエネルギー(全グルコースの5分の1,酸素の4分の1)を必要とする.膨大な酸素とグルコースは,ミトコンドリアの酸化的リン酸化という代謝過程を経てATPにエネルギー転換され,これは神経細胞の静止膜電位の維持に消費される.脳は高度に機能分化した局所の集合体でもあり,血管系と神経系が緻密に連携することで,エネルギーを細部へ効果的に届けることができている.この脳の特徴-グルコース酸化と神経血管カップリング-から,統合失調症の代謝と構造について概説し,統合失調症研究の再現性問題を解決する方策の1例として,症候群から抽出した糖化ストレスを伴う小亜種を紹介した.脳構造を個人差レベルまで識別できる解像度をもつ放射光ナノCT法により,脳血管と神経細胞の構造アンバランスを同定した自験例を,統合失調症のエネルギー代謝研究への応用例として紹介した.(著者抄録)

Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00755&link_issn=&doc_id=20221031250002&doc_link_id=vol%3D124%26year%3D2022%26mag%3D0%26number%3D10%26start%3D688&url=https%3A%2F%2Fjournal.jspn.or.jp%2FDisp%3Fstyle%3Dabst%26vol%3D124%26year%3D2022%26mag%3D0%26number%3D10%26start%3D688&type=%E7%B2%BE%E7%A5%9E%E7%A5%9E%E7%B5%8C%E5%AD%A6%E9%9B%91%E8%AA%8C&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00022_2.gif
Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia. International journal

Saeko Takase, Jingzhu Liao, Yue Liu, Rinako Tanaka, Yasuhiro Miyagawa, Masahito Sawahata, Akira Sobue, Hiroyuki Mizoguchi, Taku Nagai, Kozo Kaibuchi, Norio Ozaki, Kiyofumi Yamada

European journal of pharmacology Vol. 931 page： 175207 - 175207 2022.9

　More details

Language：English Publishing type：Research paper (scientific journal)

Current antipsychotics used to treat schizophrenia have associated problems, including serious side effects and treatment resistance. We recently identified a significant association of schizophrenia with exonic copy number variations in the Rho GTPase activating protein 10 (ARHGAP10) gene using genome-wide analysis. ARHGAP10 encodes a RhoGAP superfamily member that is involved in small GTPase signaling. In mice, Arhgap10 gene variations result in RhoA/Rho-kinase pathway activation. We evaluated the pharmacokinetics of fasudil and hydroxyfasudil using liquid chromatography-tandem mass spectrometry in mice. The antipsychotic effects of fasudil on hyperlocomotion, social interaction deficits, prepulse inhibition deficits, and novel object recognition deficits were also investigated in a MK-801-treated pharmacological mouse schizophrenia model. Fasudil and its major metabolite, hydroxyfasudil, were detected in the brain at concentrations above their respective Ki values for Rho-kinase after intraperitoneal injection of 10 mg kg-1 fasudil. Fasudil improved the hyperlocomotion, social interaction deficits, prepulse inhibition deficits, and novel object recognition deficits in MK-801-treated mice in a dose-dependent manner. Following oral administration of fasudil, brain hydroxyfasudil was detected at concentration above the Ki value for Rho-kinase whilst fasudil was undetectable. MK-801-induced hyperlocomotion was also improved by oral fasudil administration. These results suggest that fasudil has antipsychotic-like effects on the MK-801-treated pharmacological mouse schizophrenia model. There are two isoforms in Rho-kinase, and further investigation is needed to clarify the isoforms involved in the antipsychotic-like effects of fasudil in the MK-801-treated mouse schizophrenia model.

DOI： 10.1016/j.ejphar.2022.175207

Web of Science

PubMed
Case series of four psychiatric patients with copy number variations in the neurexin 1 gene

Itaru Kushima, Toshiya Inada, Kazutaka Ohi, Jun Egawa, Norio Ozaki

Psychiatry and Clinical Neurosciences Reports Vol. 1 ( 3 ) 2022.9

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

DOI： 10.1002/pcn5.36

Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/pcn5.36
Cross-disorder analysis of genic and regulatory copy number variations in bipolar disorder, schizophrenia, and autism spectrum disorder

Itaru Kushima, Masahiro Nakatochi, Branko Aleksic, Takashi Okada, Hiroki Kimura, Hidekazu Kato, Mako Morikawa, Toshiya Inada, Kanako Ishizuka, Youta Torii, Yukako Nakamura, Satoshi Tanaka, Miho Imaeda, Nagahide Takahashi, Maeri Yamamoto, Kunihiro Iwamoto, Yoshihiro Nawa, Nanayo Ogawa, Shuji Iritani, Yu Hayashi, Tzuyao Lo, Gantsooj Otgonbayar, Sho Furuta, Nakao Iwata, Masashi Ikeda, Takeo Saito, Kohei Ninomiya, Tomo Okochi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kenichiro Miura, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Kazutaka Ohi, Toshiki Shioiri, Kiyoyuki Kitaichi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Tsukasa Sasaki, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Hitoshi Kuwabara, Tomoyasu Wakuda, Takahiro A. Kato, Shigenobu Kanba, Hideki Horikawa, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Takeo Yoshikawa, Tomoko Toyota, Shigeru Yokoyama, Toshio Munesue, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Minyoung Jung, Kiyoto Kasai, Tempei Ikegame, Seiichiro Jinde, Shusuke Numata, Makoto Kinoshita, Tadafumi Kato, Chihiro Kakiuchi, Kazuhiro Yamakawa, Toshimitsu Suzuki, Naoki Hashimoto, Shuhei Ishikawa, Bun Yamagata, Shintaro Nio, Toshiya Murai, Shuraku Son, Yasuto Kunii, Hirooki Yabe, Masumi Inagaki, Yu-ichi Goto, Yuto Okumura, Tomoya Ito, Yuko Arioka, Daisuke Mori, Norio Ozaki

Biological Psychiatry Vol. 92 ( 5 ) page： 362 - 374 2022.9

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.biopsych.2022.04.003

Web of Science

PubMed
A Reactive Metabolite of Clozapine Induces Hematopoietic Toxicity in HL-60 Cells Undergoing Granulocytic Differentiation through Its Effect on Glutathione Metabolism

Torii-Goto Aya, Yoshimi Akira, Tashiro Yuko, Ukigai Mako, Matsumoto Aoi, Ozaki Norio, Noda Yukihiro

BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol. 45 ( 9 ) page： 1232 - 1237 2022.9

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Psychological impact on patients with oral cancer before undergoing resection and free flap reconstruction surgery

Satoshi Yamaguchi, Kento Kaminogo, Tatsuya Tokura, Hiroyuki Kimura, Shinichi Kishi, Noriyuki Yamamoto, Norihisa Ichimura, Naoto Toyama, Yoshiro Koma, Naoka Kouyama, Norio Ozaki, Hideharu Hibi

Oral Oncology Reports Vol. 3-4 page： 100004 - 100004 2022.9

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.oor.2022.100004
Contribution of copy number variations to the risk of severe eating disorders

Itaru Kushima, Miho Imaeda, Satoshi Tanaka, Hidekazu Kato, Tomoko Oya‐Ito, Masahiro Nakatochi, Branko Aleksic, Norio Ozaki

Psychiatry and Clinical Neurosciences Vol. 76 ( 9 ) page： 423 - 428 2022.9

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

DOI： 10.1111/pcn.13430

Web of Science

PubMed

Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pcn.13430
精神科外来患者における抗うつ薬および抗不安薬の多剤併用処方状況に関する調査

肥田裕丈, 磯貝里奈, 野口健, 堀田彰悟, 吉見陽, 尾崎紀夫, 山田清文, 野田幸裕

医療薬学 Vol. 48 ( 9 ) page： 359 - 367 2022.9

　More details

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(一社)日本医療薬学会

当院における抗うつ薬や抗不安薬の適正使用を推進するため、1997年、2003年、2005年、2007年、2013年、2015年、2018年の精神科および親と子どもの心療科における抗うつ薬、抗不安薬の処方状況を調査した。各年の代表を5日間として無作為に抽出し、対象患者2780名の年齢、性別、処方内容を集計した。各年とも精神科外来患者の約30～50%が抗うつ薬を服用しており、新規抗うつ薬の単剤処方は抗うつ薬の十分量相当にて処方されていた。抗うつ薬服用患者における抗不安薬の併用率とジアゼパム換算値は年々減少しており、抗精神病薬の併用削減が進んでいると考えられた。抗うつ薬の適正使用の推進に向けて、単剤処方、特に新規抗うつ薬の単剤処方と併用処方の有用性や安全性を比較し、新規抗うつ薬単剤処方の優越性について検討する必要性が示唆された。
Functional connector hubs in the cerebellum International journal

Kazuya Kawabata, Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Reiko Ohdake, Michihito Masuda, Aya Ogura, Toshiyasu Kato, Shuji Koyama, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

NeuroImage Vol. 257 page： 119263 - 119263 2022.8

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

Accumulating evidence from anatomical and neuroimaging studies suggests that the cerebellum is engaged in a variety of motor and cognitive tasks. Given its various functions, a key question is whether the cerebellum also plays an important role in the brain's integrative functions. Here, we hypothesize the existence of connector regions, also known as connector hubs, where multiple resting state networks converged in the cerebellum. To verify this, we employed a recently developed voxel-level network measure called functional connectivity overlap ratio (FCOR), which could be used to quantify the spatial extent of a region's connection to several large-scale cortical networks. Using resting state functional MRI data from 101 healthy participants, cerebellar FCOR maps were constructed and used to identify the locations of connector hubs in the cerebellum. Results showed that a number of cerebellar regions exhibited strong connectivity with multiple functional networks, verifying our hypothesis. These highly connected regions were located in the posterior cerebellum, especially in lobules VI, VII, and IX, and mainly connected to the core neurocognitive networks such as default mode and executive control networks. Regions associated with the sensorimotor network were also localized in lobule V, VI, and VIII, albeit in small clusters. These cerebellar connector hubs may play an essential role in the processing of information across the core neurocognitive networks.

DOI： 10.1016/j.neuroimage.2022.119263

Web of Science

PubMed
Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach - CORRIGENDUM. International journal

Micah Cearns, Azmeraw T Amare, Klaus Oliver Schubert, Anbupalam Thalamuthu, Joseph Frank, Fabian Streit, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, JeanMichel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, HsiChung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M Czerski, Nina Dalkner, Alexandre Dayer, Franziska Degenhardt, Maria Del Zompo, J Raymond DePaulo, Bruno Étain, Peter Falkai, Andreas J Forstner, Louise Frisen, Mark A Frye, Janice M Fullerton, Sébastien Gard, Julie S Garnham, Fernando S Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Andrea Hofmann, Liping Hou, Yi-Hsiang Hsu, Stephane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Markus M Nöthen, Tomas Novák, Claire O'Donovan, Norio Ozaki, Vincent Millischer, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B Potash, Andreas Reif, Eva Reininghaus, Guy A Rouleau, Janusz K Rybakowski, Martin Schalling, Peter R Schofield, Barbara W Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fasil TekolaAyele, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Stephanie H Witt, Gloria Roberts, Peter P Zandi, Martin Alda, Michael Bauer, Francis J McMahon, Philip B Mitchell, Thomas G Schulze, Marcella Rietschel, Scott R Clark, Bernhard T Baune

The British journal of psychiatry : the journal of mental science Vol. 221 ( 2 ) page： 494 - 494 2022.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1192/bjp.2022.55

PubMed
ドライビングシミュレーターによる健常者の運転技能と視線特性との関係性

田中陽子, 宮田聖子, 岩本邦弘, 山本真江里, 三浦健一郎, 橋本亮太, 尾崎紀夫

日本安全運転医療学会誌 Vol. 2 ( 1 ) page： 46 - 53 2022.8

　More details

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本安全運転医療学会

道路交通法により体調不良時の自動車運転は禁止されているが,患者に運転の可否を指導する上での医学的なエビデンスは乏しく,適切な指導のもと患者が自動車社会で生活するためには,運転技能に関わる医学的知見を蓄積することが求められる.運転技能に必須である視覚,認知機能,運動機能の中でも,とりわけ視覚情報は運転中に得られる情報の90%にも及び,視覚を支える視線を促えることが運転技能を予測する上で有用な可能性がある.そこで,本研究では,視線の基本的特性と運転技能との関連にっいて検討を行うため,同一被験者にて運転と視線計測を行った健常者36名を対象に運転と視線の関連にっいて解折した.運転課題は車線維持課題(横揺れの指標),急ブレーキ課題(反応時間の指標)を実施し,視線課題では,フリービューイング課題,固視課題,パシュート課題を実施した.運転の指標と視線の指標との相関解析により,横揺れの指標はフリービュ一イング課題におけるフィクセーション,サッケード関連指標,視線移動の総距離,およびパシュート課題におけるサッケード,垂直方向の視線移動に関する指標と有意な相関を示した.また,反応時間の指標はパシュート課題におけるサッケー一ドおよび垂直方向の視線移動の指標と有意な相関を示した.以上より,視線解析におけるサッケードや視線移動距離といった指標は,運転技能を予測できる可能性が示された.(著者抄録)
The genetic architecture of schizophrenia: review of large-scale genetic studies

Hidekazu Kato, Hiroki Kimura, Itaru Kushima, Nagahide Takahashi, Branko Aleksic, Norio Ozaki

Journal of Human Genetics Vol. 68 ( 3 ) page： 175 - 182 2022.7

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

DOI： 10.1038/s10038-022-01059-4

Web of Science

PubMed

Other Link： https://www.nature.com/articles/s10038-022-01059-4
Correction: Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients. International journal

Klaus Oliver Schubert, Anbupalam Thalamuthu, Azmeraw T Amare, Joseph Frank, Fabian Streit, Mazda Adl, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M Biernacka, Armin Birner, Cynthia Marie-Claire, Micah Cearns, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Scott R Clark, Cristiana Cruceanu, Piotr M Czerski, Nina Dalkner, Alexandre Dayer, Franziska Degenhardt, Maria Del Zompo, J Raymond DePaulo, Bruno Étain, Peter Falkai, Andreas J Forstner, Louise Frisen, Mark A Frye, Janice M Fullerton, Sébastien Gard, Julie S Garnham, Fernando S Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Liping Hou, Yi-Hsiang Hsu, Stephane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Markus M Nöthen, Tomas Novák, Claire O'Donovan, Norio Ozaki, Urban Ösby, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B Potash, Andreas Reif, Eva Reininghaus, Guy A Rouleau, Janusz K Rybakowski, Martin Schalling, Peter R Schofield, Barbara W Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fasil Tekola-Ayele, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Stephanie H Witt, Gloria Roberts, Peter P Zandi, Martin Alda, Michael Bauer, Francis J McMahon, Philip B Mitchell, Thomas G Schulze, Marcella Rietschel, Bernhard T Baune

Translational psychiatry Vol. 12 ( 1 ) page： 278 - 278 2022.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41398-022-02037-2

PubMed
Exome sequencing analysis of Japanese autism spectrum disorder case-control sample supports an increased burden of synaptic function-related genes International journal

Hiroki Kimura, Masahiro Nakatochi, Branko Aleksic, James Guevara, Miho Toyama, Yu Hayashi, Hidekazu Kato, Itaru Kushima, Mako Morikawa, Kanako Ishizuka, Takashi Okada, Yoshinori Tsurusaki, Atsushi Fujita, Noriko Miyake, Tomoo Ogi, Atsushi Takata, Naomichi Matsumoto, Joseph Buxbaum, Norio Ozaki, Jonathan Sebat

Translational Psychiatry Vol. 12 ( 1 ) page： 265 - 265 2022.7

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Autism spectrum disorder (ASD) is a highly heritable, complex disorder in which rare variants contribute significantly to disease risk. Although many genes have been associated with ASD, there have been few genetic studies of ASD in the Japanese population. In whole exomes from a Japanese ASD sample of 309 cases and 299 controls, rare variants were associated with ASD within specific neurodevelopmental gene sets, including highly constrained genes, fragile X mental retardation protein target genes, and genes involved in synaptic function, with the strongest enrichment in trans-synaptic signaling (p = 4.4 × 10−4, Q-value = 0.06). In particular, we strengthen the evidence regarding the role of ABCA13, a synaptic function-related gene, in Japanese ASD. The overall results of this case-control exome study showed that rare variants related to synaptic function are associated with ASD susceptibility in the Japanese population.

DOI： 10.1038/s41398-022-02033-6

Web of Science

PubMed

Other Link： https://www.nature.com/articles/s41398-022-02033-6
Polysomnographic characteristics and predictors of positional obstructive sleep apnea in Japanese elderly

Miyata Seiko, Otake Hironao, Fujishiro Hiroshige, Iwamoto Kunihiro, Noda Akiko, Sone Michihiko, Ozaki Norio

SLEEP AND BIOLOGICAL RHYTHMS Vol. 20 ( 3 ) page： 403 - 411 2022.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s41105-022-00385-6

Web of Science
Treatment-resistant schizophrenia in patients with 3q29 deletion: A case series of four patients. International journal

Yoshihiro Nawa, Itaru Kushima, Branko Aleksic, Maeri Yamamoto, Hiroyuki Kimura, Masahiro Banno, Ryota Hashimoto, Norio Ozaki

Psychiatry and clinical neurosciences Vol. 76 ( 7 ) page： 338 - 339 2022.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.13361

Web of Science

PubMed
Striatal 123 I‐2β‐carbomethoxy‐3b‐(4‐iodophenyl)‐N‐(3‐fluoropropyl)‐nortropane single‐photon emission computed tomography demonstrates nigral degeneration in the early stage of behavioural variant frontotemporal dementia: an autopsy case with frontotemporal lobar degeneration with trans‐activation response DNA protein 43 type B International journal

Shusei Arafuka, Hiroshige Fujishiro, Shuji Iritani, Youta Torii, Ayako Miwa, Hiroyuki Yabata, Hirotaka Sekiguchi, Chikako Habuchi, Kunihiro Kawashima, Mari Yoshida, Yasushi Iwasaki, Norio Ozaki

Psychogeriatrics Vol. 22 ( 4 ) page： 580 - 585 2022.7

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

DOI： 10.1111/psyg.12842

Web of Science

PubMed

Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/psyg.12842
Psychiatric patients with a de novo 17q12 deletion: two case reports. International journal

Itaru Kushima, Mariko Uematsu, Kanako Ishizuka, Branko Aleksic, Norio Ozaki

Psychiatry and clinical neurosciences Vol. 76 ( 7 ) page： 345 - 347 2022.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.13367

Web of Science

PubMed
Prevalence, clinical features, and risk factors of delusions in patients with delirium. International journal

Masako Tachibana, Toshiya Inada, Masaru Ichida, Norio Ozaki

International journal of geriatric psychiatry Vol. 37 ( 6 ) 2022.6

　More details

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: Delirium may be divided into multiple subtypes with different pathological factors. This study aimed to focus on the delirium subtype in which delusions are conspicuous and explore its prevalence, clinical characteristics, and risk factors. METHODS: The subjects were 601 delirium cases referred to the department of psychiatry over 5 years at a general hospital. The Delirium Rating Scale-Revised-98 was used to assess the delusions in patients with delirium, and the features of delusions (delusional form, object, and content) were examined. Multiple regression analysis was applied to determine whether individual factors were associated with the delusions. RESULTS: A total of 78 patients with delirium experienced delusions (13.0%). Most were classified as delusion of reference, such as persecution or poisoning, and 84.3% of patients believed that the persecutors were medical staff members. Older age (p < 0.001), female gender (p < 0.001), and living alone (p < 0.001) were significantly associated with delusions in patients with delirium. CONCLUSIONS: The content of delusions was rooted in the distress caused by the patients' medical situation, and the features and risk factors of the delusions suggested a formal similarity with late paraphrenia and "lack-of-contact paranoia." Psychological interventions that consider the isolation, anxiety, and fear behind delusions may be necessary in the care and treatment of these patients.

DOI： 10.1002/gps.5763

Web of Science

PubMed
Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology International journal

Koyo Tsujikawa, Kohei Hamanaka, Yuichi Riku, Yuki Hattori, Norikazu Hara, Yohei Iguchi, Shinsuke Ishigaki, Atsushi Hashizume, Satoko Miyatake, Satomi Mitsuhashi, Yu Miyazaki, Mayumi Kataoka, Li Jiayi, Keizo Yasui, Satoshi Kuru, Haruki Koike, Kenta Kobayashi, Naruhiko Sahara, Norio Ozaki, Mari Yoshida, Akiyoshi Kakita, Yuko Saito, Yasushi Iwasaki, Akinori Miyashita, Takeshi Iwatsubo, Takeshi Ikeuchi, Takaki Miyata, Gen Sobue, Naomichi Matsumoto, Kentaro Sahashi, Masahisa Katsuno

Science Advances Vol. 8 ( 21 ) page： eabm5029 2022.5

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：American Association for the Advancement of Science (AAAS)

While amyloid-β lies upstream of tau pathology in Alzheimer’s disease, key drivers for other tauopathies, including progressive supranuclear palsy (PSP), are largely unknown. Various tau mutations are known to facilitate tau aggregation, but how the nonmutated tau, which most cases with PSP share, increases its propensity to aggregate in neurons and glial cells has remained elusive. Here, we identified genetic variations and protein abundance of filamin-A in the PSP brains without tau mutations. We provided in vivo biochemical evidence that increased filamin-A levels enhance the phosphorylation and insolubility of tau through interacting actin filaments. In addition, reduction of filamin-A corrected aberrant tau levels in the culture cells from PSP cases. Moreover, transgenic mice carrying human filamin-A recapitulated tau pathology in the neurons. Our data highlight that filamin-A promotes tau aggregation, providing a potential mechanism by which filamin-A contributes to PSP pathology.

DOI： 10.1126/sciadv.abm5029

Web of Science

PubMed
Driving performance of euthymic outpatients with bipolar disorder undergoing real-world pharmacotherapy. International journal

Akiko Yamaguchi, Kunihiro Iwamoto, Masahiko Ando, Kiyoshi Fujita, Motonori Yokoyama, Tsuyoshi Akiyama, Yoshio Igarashi, Norio Ozaki

Psychiatry and clinical neurosciences Vol. 76 ( 5 ) page： 172 - 178 2022.5

　More details

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Medications for the treatment of bipolar disorder (BD) could affect patients' cognitive function. Patients with BD present with neurocognitive impairment even in a remission state. Little research is available on the daily functioning, especially driving performance, of stable outpatients with BD under pharmacological treatment. METHODS: In total, 58 euthymic outpatients with BD undergoing real-world pharmacotherapy and 80 sex- and age-matched healthy controls (HCs) were enrolled. Three driving tasks using a driving simulator-road-tracking, car-following, and harsh-braking-and three cognitive tasks-Continuous Performance Test, Wisconsin Card Sorting Test, and Trail-Making Test-were evaluated. Symptom assessment scales-Young Mania Rating Scale, Structured Interview Guide for the Hamilton Depression Rating Scale, Beck Depression Inventory-II, Social Adaptation Self-evaluation Scale, and Stanford Sleepiness Scale-were also completed. RESULTS: Car-following and road-tracking performance were significantly impaired in patients with BD compared with HCs after adjusting for demographic variables, but these performances generally overlapped. Broad neurocognitive functions were significantly lower in the patients with BD compared to HCs, but car-following performance was significantly negatively correlated with sustained attention only. Although most patients received multiple medications rather than monotherapy, no relationship between prescriptions and driving performance was found. CONCLUSION: Euthymic patients with BD under steady-state pharmacotherapy had impaired driving performance compared with HCs, but the overlapping distributions of driving performance suggested that driving performance is not always deteriorated in patients with BD. Therefore, attentional function may be a useful clinical feature for judging driving aptitude in patients with BD. This article is protected by copyright. All rights reserved.

DOI： 10.1111/pcn.13332

Web of Science

PubMed
Investigation of OLIG2 as a candidate gene for schizophrenia and autism spectrum disorder.

Sho Furuta, Branko Aleksic, Yoshihiro Nawa, Hiroki Kimura, Itaru Kushima, Kanako Ishizuka, Hidekazu Kato, Miho Toyama, Yuko Arioka, Daisuke Mori, Mako Morikawa, Toshiya Inada, Norio Ozaki

Nagoya journal of medical science Vol. 84 ( 2 ) page： 260 - 268 2022.5

　More details

Language：English Publishing type：Research paper (scientific journal)

A number of genomic mutations that are thought to be strongly involved in the development of schizophrenia (SCZ) and autism spectrum disorder (ASD) have been identified. Abnormalities involving oligodendrocytes have been reported in SCZ, and as a related gene, oligodendrocyte lineage transcription factor 2 (OLIG2) has been reported to be strongly associated with SCZ. In this study, based on the common disease-rare variant hypothesis, target sequencing of candidate genes was performed to identify rare mutations with a high effect size and the possibility that the identified mutations may increase the risks of SCZ and ASD in the Japanese population. In this study, the exon region of OLIG2 was targeted; 370 patients with SCZ and 192 with ASD were subjected to next-generation sequencing. As a result, one rare missense mutation (A33T) was detected. We used the Sanger method to validate this missense mutation with a low frequency (<1%), and then carried out a genetic association analysis involving 3299 unrelated individuals (1447 with SCZ, 380 with ASD, and 1472 healthy controls) to clarify whether A33T was associated with SCZ or ASD. A33T was not found in either case group, and in only one control. We did not find evidence that p.A33T is involved in the onset of ASD or SCZ; however, associations with this variant need to be evaluated in larger samples to confirm our results.

DOI： 10.18999/nagjms.84.2.260

Web of Science

PubMed
Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial International journal

Hidenori Yamasue, Masaki Kojima, Hitoshi Kuwabara, Miho Kuroda, Kaori Matsumoto, Chieko Kanai, Naoko Inada, Keiho Owada, Keiko Ochi, Nobutaka Ono, Seico Benner, Tomoyasu Wakuda, Yosuke Kameno, Jun Inoue, Taeko Harada, Kenji Tsuchiya, Kazuo Umemura, Aya Yamauchi, Nanayo Ogawa, Itaru Kushima, Norio Ozaki, Satoshi Suyama, Takuya Saito, Yukari Uemura, Junko Hamada, Yukiko Kano, Nami Honda, Saya Kikuchi, Moe Seto, Hiroaki Tomita, Noriko Miyoshi, Megumi Matsumoto, Yuko Kawaguchi, Koji Kanai, Manabu Ikeda, Itta Nakamura, Shuichi Isomura, Yoji Hirano, Toshiaki Onitsuka, Hirotaka Kosaka, Takashi Okada

Brain Vol. 145 ( 2 ) page： 490 - 499 2022.4

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

Abstract

Although intranasal oxytocin is expected to be a novel therapy for the core symptoms of autism spectrum disorder, which has currently no approved medication, the efficacy of repeated administrations was inconsistent, suggesting that the optimal dose for a single administration of oxytocin is not optimal for repeated administration.

The current double-blind, placebo-controlled, multicentre, crossover trial (ClinicalTrials.gov Identifier: NCT03466671) was aimed to test the effect of TTA-121, a new formulation of intranasal oxytocin spray with an enhanced bioavailability (3.6 times higher than Syntocinon® spray, as assessed by area under the concentration–time curve in rabbit brains), which enabled us to test a wide range of multiple doses, on autism spectrum disorder core symptoms and to determine the dose–response relationship. Four-week administrations of TTA-121, at low dose once per day (3 U/day), low dose twice per day (6 U/day), high dose once per day (10 U/day), or high dose twice per day (20 U/day), and 4-week placebo were administered in a crossover manner. The primary outcome was the mean difference in the reciprocity score (range: 0–14, higher values represent worse outcomes) on the Autism Diagnostic Observation Schedule between the baseline and end point of each administration period. This trial with two administration periods and eight groups was conducted at seven university hospitals in Japan, enrolling adult males with high-functioning autism spectrum disorder. Enrolment began from June 2018 and ended December 2019. Follow-up ended March 2020.

Of 109 males with high-functioning autism spectrum disorder who were randomized, 103 completed the trial. The smallest P-value, judged as the dose–response relationship, was the contrast with the peak at TTA-121 6 U/day, with inverted U-shape for both the full analysis set (P = 0.182) and per protocol set (P = 0.073). The Autism Diagnostic Observation Schedule reciprocity score, the primary outcome, was reduced in the TTA-121 6 U/day administration period compared with the placebo (full analysis set: P = 0.118, mean difference = −0.5; 95% CI: −1.1 to 0.1; per protocol set: P = 0.012, mean difference = −0.8; 95% CI: −1.3 to −0.2). The per protocol set was the analysis target population, consisting of all full analysis set participants except those who deviated from the protocol. Most dropouts from the full analysis set to the per protocol set occurred because of poor adherence to the test drug (9 of 12 in the first period and 8 of 15 in the second period). None of the secondary clinical and behavioural outcomes were significantly improved with the TTA-121 compared with the placebo in the full analysis set.

A novel intranasal spray of oxytocin with enhanced bioavailability enabled us to test a wide range of multiple doses, revealing an inverted U-shape dose–response curve, with the peak at a dose that was lower than expected from previous studies. The efficacy of TTA-121 shown in the current exploratory study should be verified in a future large-scale, parallel-group trial.

DOI： 10.1093/brain/awab291

Web of Science

PubMed

Other Link： https://academic.oup.com/brain/article-pdf/145/2/490/43402326/awab291.pdf
Correction to: Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome. International journal

Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Molecular brain Vol. 15 ( 1 ) page： 34 - 34 2022.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s13041-022-00920-z

Web of Science

PubMed
Atezolizumab, an immune checkpoint inhibitor, caused precedent depressive symptoms related to limbic encephalitis

Wada Shuhei, Iwamoto Kunihiro, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 76 ( 4 ) page： 125 - 126 2022.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.13325

Web of Science

PubMed
Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach International journal

Micah Cearns, Azmeraw T. Amare, Klaus Oliver Schubert, Anbupalam Thalamuthu, Joseph Frank, Fabian Streit, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, B{\'{a } }rbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alex, re Dayer, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Bruno {\'{E } }tain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, S{\'{e } }bastien Gard, Julie S. Garnham, Fern, o S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Andrea Hofmann, Liping Hou, Yi-Hsiang Hsu, Stephane Jamain, Esther Jim{\'{e } }nez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael L, {\'{e } }n, Catharina Lavebratt, Marion Leboyer, Susan G. Leckb, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nöthen, Tomas Nov{\'{a } }k, Claire O{\textquotesingle}Donovan, Norio Ozaki, Vincent Millischer, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Katzutaka Shimoda, Christian Simh, l, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fasil Tekola-Ayele, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Stephanie H. Witt, Gloria Roberts, Peter P. Z, i, Martin Alda, Michael Bauer, Francis J. McMahon, Philip B. Mitchell, Thomas G. Schulze, Marcella Rietschel, Scott R. Clark, Bernhard T. Baune

The British Journal of Psychiatry Vol. 220 ( 4 ) page： 219 - 228 2022.4

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Royal College of Psychiatrists

<jats:sec id="S0007125022000289_sec_a1">
<jats:title>Background</jats:title>
<jats:p>Response to lithium in patients with bipolar disorder is associated with clinical and transdiagnostic genetic factors. The predictive combination of these variables might help clinicians better predict which patients will respond to lithium treatment.</jats:p>
</jats:sec>
<jats:sec id="S0007125022000289_sec_a2">
<jats:title>Aims</jats:title>
<jats:p>To use a combination of transdiagnostic genetic and clinical factors to predict lithium response in patients with bipolar disorder.</jats:p>
</jats:sec>
<jats:sec id="S0007125022000289_sec_a3" sec-type="methods">
<jats:title>Method</jats:title>
<jats:p>This study utilised genetic and clinical data (<jats:italic>n</jats:italic> = 1034) collected as part of the International Consortium on Lithium Genetics (ConLi<jats:sup>+</jats:sup>Gen) project. Polygenic risk scores (PRS) were computed for schizophrenia and major depressive disorder, and then combined with clinical variables using a cross-validated machine-learning regression approach. Unimodal, multimodal and genetically stratified models were trained and validated using ridge, elastic net and random forest regression on 692 patients with bipolar disorder from ten study sites using leave-site-out cross-validation. All models were then tested on an independent test set of 342 patients. The best performing models were then tested in a classification framework.</jats:p>
</jats:sec>
<jats:sec id="S0007125022000289_sec_a4" sec-type="results">
<jats:title>Results</jats:title>
<jats:p>The best performing linear model explained 5.1% (<jats:italic>P</jats:italic> = 0.0001) of variance in lithium response and was composed of clinical variables, PRS variables and interaction terms between them. The best performing non-linear model used only clinical variables and explained 8.1% (<jats:italic>P</jats:italic> = 0.0001) of variance in lithium response. <jats:italic>A priori</jats:italic> genomic stratification improved non-linear model performance to 13.7% (<jats:italic>P</jats:italic> = 0.0001) and improved the binary classification of lithium response. This model stratified patients based on their meta-polygenic loadings for major depressive disorder and schizophrenia and was then trained using clinical data.</jats:p>
</jats:sec>
<jats:sec id="S0007125022000289_sec_a5" sec-type="conclusions">
<jats:title>Conclusions</jats:title>
<jats:p>Using PRS to first stratify patients genetically and then train machine-learning models with clinical predictors led to large improvements in lithium response prediction. When used with other PRS and biological markers in the future this approach may help inform which patients are most likely to respond to lithium treatment.</jats:p>
</jats:sec>

DOI： 10.1192/bjp.2022.28

Web of Science

PubMed
Case report of a female with bipolar disorder and <scp> MBD5 </scp> deletion

Itaru Kushima, Tzuyao Lo, Branko Aleksic, Norio Ozaki

Psychiatry and Clinical Neurosciences Vol. 76 ( 4 ) page： 127 - 128 2022.4

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

DOI： 10.1111/pcn.13329

Web of Science

PubMed

Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pcn.13329
【精神科ブレインバンク】ゲノム解析研究とブレインバンク

荒深周生, 鳥居洋太, 尾崎紀夫

精神科 Vol. 40 ( 4 ) page： 422 - 429 2022.4

　More details

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(有)科学評論社
Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome International journal

Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Molecular Brain Vol. 15 ( 1 ) page： 26 - 26 2022.3

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by specific social symptoms, restricted interests, stereotyped repetitive behaviors, and delayed language development. The 3q29 microdeletion (3q29del), a recurrent copy number variant, confers a high risk for ASD and schizophrenia, and serves as an important pathological model for investigating the molecular pathogenesis of a large number of neurodevelopmental and psychiatric conditions. Recently, mouse models carrying a deletion of the chromosomal region corresponding to the human 3q29 region (Df/+ mice) were generated and demonstrated neurodevelopmental and psychiatric conditions associated behavioral abnormalities, pointing to the relevance of Df/+ mice as a model for these conditions with high construct and face validity. Currently, the molecular pathogenesis of these behavioral phenotypes in Df/+ mice remains unclear. The oxytocin (OXT) system plays a central role in social behavior across species and has a potential role in ASD. In this study, to elucidate the molecular mechanisms behind impaired social behavior in Df/+ mice, we investigated the possible involvement of OXT signaling in impaired social behavior in Df/+ mice. We demonstrated that OXT administration restored the impaired social behavior in Df/+ mice. We also demonstrated that the number of OXT-positive cells in the paraventricular nucleus (PVN) was significantly lower in Df/+ mice than in wild-type (WT) littermates. Consistent with this, the level of OXT peptide in the cerebral cortex of Df/+ mice was lower than in WT littermates. Our study may provide important insights into the molecular pathophysiological basis of neurodevelopmental and psychiatric conditions, including ASD.

DOI： 10.1186/s13041-022-00915-w

Web of Science

PubMed

Other Link： https://link.springer.com/article/10.1186/s13041-022-00915-w/fulltext.html
Duloxetine attenuates pain in association with downregulation of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia.

Nakamura M, Yoshimi A, Mouri A, Tokura T, Kimura H, Kishi S, Miyauchi T, Iwamoto K, Ito M, Sato-Boku A, Ozaki N, Nabeshima T, Noda Y

Human psychopharmacology Vol. 37 ( 2 ) page： e2818 2022.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.2818

PubMed
Severe and long-lasting neuropsychiatric symptoms after mild respiratory symptoms caused by COVID-19: A case report. International journal

Ryosuke Jozuka, Hiroki Kimura, Takashi Uematsu, Hidetsugu Fujigaki, Yasuko Yamamoto, Masato Kobayashi, Kazuya Kawabata, Haruki Koike, Toshiya Inada, Kuniaki Saito, Masahisa Katsuno, Norio Ozaki

Neuropsychopharmacology reports Vol. 42 ( 1 ) page： 114 - 119 2022.3

　More details

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Coronavirus disease 2019 (COVID-19) is known to cause not only respiratory but also neuropsychiatric symptoms, which are assumed to be derived from a cytokine storm and its effects on the central nervous systems. Patients with COVID-19 who develop severe respiratory symptoms are known to show severe neuropsychiatric symptoms such as cerebrovascular disease and encephalopathy. However, the detailed clinical courses of patients with neuropsychiatric symptoms caused by mild or asymptomatic COVID-19 remain poorly understood. Here, we present a case of COVID-19 who presented with severe and prolonged neuropsychiatric symptoms subsequent to mild respiratory symptoms. CASE PRESENTATION: A 55-year-old female with COVID-19 accompanied by mild respiratory symptoms showed delusion, psychomotor excitement, and poor communication ability during quarantine outside the hospital. Considering her diminished respiratory symptoms, her neuropsychiatric symptoms were initially regarded as psychogenic reactions. However, as she showed progressive disturbance of consciousness accompanied by an abnormal electroencephalogram, she was diagnosed with post-COVID-19 encephalopathy. Although her impaired consciousness and elevated cytokine level improved after steroid pulse therapy, several neuropsychiatric symptoms, including a loss of concentration, unsteadiness while walking, and fatigue, remained. CONCLUSIONS: This case suggests the importance of both recognizing that even apparently mild COVID-19-related respiratory symptoms can lead to severe and persistent neuropsychiatric symptoms, and elucidating the mechanisms, treatment, and long-term course of COVID-19-related neuropsychiatric symptoms in the future.

DOI： 10.1002/npr2.12222

PubMed
Residual effects of zopiclone on driving performance using a standardized driving simulator among healthy volunteers. International journal

Kunihiro Iwamoto, Mari Iwata, Daiji Kambe, Yumiko Imadera, Naoki Tachibana, Yu Kajiyama, Masahiko Ando, Norio Ozaki

Psychopharmacology Vol. 239 ( 3 ) page： 841 - 850 2022.3

　More details

Language：English Publishing type：Research paper (scientific journal)

RATIONALE: The effects of hypnotics on automobile driving have been attracting increasing attention. However, few driving simulators (DSs) have been confirmed to have acceptable reliability and validity for assessing the next-day residual effects of zopiclone as a positive control on driving performance. OBJECTIVE: To investigate whether a new DS could permit detection of the next-day residual effects of zopiclone on driving performance. METHODS: In this double-blind, randomized, placebo-controlled crossover trial, 28 healthy males received zopiclone 7.5 mg at bedtime on days 1 and 8 and placebo on the other days over a period of 16 days. The participants took part in three driving tasks-road-tracking, car-following, and harsh-braking-using a DS on days 2 and 9 at 9-h post-dosing. Scores on the Karolinska Sleepiness Scale and Profile of Mood States-Second Edition were then assessed, as was the serum concentration of zopiclone. RESULTS: The estimated differences in the standard deviation of lateral position (cm) in the road-tracking task between the zopiclone and placebo groups on days 2 and 9 were 3.75 cm (90% confidence interval (CI): 1.71-5.79) and 4.07 cm (90% CI: 2.02-6.11), respectively. The estimated differences in the distance coefficient of variation in the car-following task and in the brake reaction time in the harsh-braking task between the zopiclone and placebo groups on day 2 were 4.31 (90% CI: 1.94-6.69) and 24.6 ms (90% CI: 12.7-36.4), respectively. CONCLUSIONS: The DS used in this study has sufficient sensitivity to detect the next-day residual effects of zopiclone on driving performance.

DOI： 10.1007/s00213-022-06075-y

Web of Science

PubMed
Variable psychiatric manifestations in patients with 16p11.2 duplication: a case series of 4 patients

Yu Hayashi, Itaru Kushima, Branko Aleksic, Tetsu Senaha, Norio Ozaki

Psychiatry and Clinical Neurosciences Vol. 76 ( 3 ) page： 86 - 88 2022.3

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

DOI： 10.1111/pcn.13324

Web of Science

PubMed

Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pcn.13324
脳内免疫系及び神経形態における幼若期の心理社会的ストレス負荷の影響

吉田樹生, 鈴木千晴, 濱田眞理亜, 肥田裕丈, 毛利彰宏, 吉見陽, 尾崎紀夫, 野田幸裕

日本薬学会年会要旨集 Vol. 142年会 page： 28PO9 - 03S 2022.3

　More details

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(公社)日本薬学会
統合失調症入院患者における抗精神病薬の処方状況と減量・減薬の実態調査多剤併用療法の解消に向けて

松本あおい, 中村真理子, 吉見陽, 肥田裕丈, 堀田彰悟, 尾崎紀夫, 山田清文, 野田幸裕

日本薬学会年会要旨集 Vol. 142年会 page： 26PO1 - 30S 2022.3

　More details

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(公社)日本薬学会
Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder. International journal

Chenyao Wang, Shin-Ichiro Horigane, Minoru Wakamori, Shuhei Ueda, Takeshi Kawabata, Hajime Fujii, Itaru Kushima, Hiroki Kimura, Kanako Ishizuka, Yukako Nakamura, Yoshimi Iwayama, Masashi Ikeda, Nakao Iwata, Takashi Okada, Branko Aleksic, Daisuke Mori, Takashi Yoshida, Haruhiko Bito, Takeo Yoshikawa, Sayaka Takemoto-Kimura, Norio Ozaki

Translational psychiatry Vol. 12 ( 1 ) page： 84 - 84 2022.2

　More details

Language：English Publishing type：Research paper (scientific journal)

Several large-scale whole-exome sequencing studies in patients with schizophrenia (SCZ) and autism spectrum disorder (ASD) have identified rare variants with modest or strong effect size as genetic risk factors. Dysregulation of cellular calcium homeostasis might be involved in SCZ/ASD pathogenesis, and genes encoding L-type voltage-gated calcium channel (VGCC) subunits Cav1.1 (CACNA1S), Cav1.2 (CACNA1C), Cav1.3 (CACNA1D), and T-type VGCC subunit Cav3.3 (CACNA1I) recently were identified as risk loci for psychiatric disorders. We performed a screening study, using the Ion Torrent Personal Genome Machine (PGM), of exon regions of these four candidate genes (CACNA1C, CACNA1D, CACNA1S, CACNA1I) in 370 Japanese patients with SCZ and 192 with ASD. Variant filtering was applied to identify biologically relevant mutations that were not registered in the dbSNP database or that have a minor allele frequency of less than 1% in East-Asian samples from databases; and are potentially disruptive, including nonsense, frameshift, canonical splicing site single nucleotide variants (SNVs), and non-synonymous SNVs predicted as damaging by five different in silico analyses. Each of these filtered mutations were confirmed by Sanger sequencing. If parental samples were available, segregation analysis was employed for measuring the inheritance pattern. Using our filter, we discovered one nonsense SNV (p.C1451* in CACNA1D), one de novo SNV (p.A36V in CACNA1C), one rare short deletion (p.E1675del in CACNA1D), and 14 NSstrict SNVs (non-synonymous SNV predicted as damaging by all of five in silico analyses). Neither p.A36V in CACNA1C nor p.C1451* in CACNA1D were found in 1871 SCZ cases, 380 ASD cases, or 1916 healthy controls in the independent sample set, suggesting that these SNVs might be ultra-rare SNVs in the Japanese population. The neuronal splicing isoform of Cav1.2 with the p.A36V mutation, discovered in the present study, showed reduced Ca2+-dependent inhibition, resulting in excessive Ca2+ entry through the mutant channel. These results suggested that this de novo SNV in CACNA1C might predispose to SCZ by affecting Ca2+ homeostasis. Thus, our analysis successfully identified several ultra-rare and potentially disruptive gene variants, lending partial support to the hypothesis that VGCC-encoding genes may contribute to the risk of SCZ/ASD.

DOI： 10.1038/s41398-022-01851-y

Web of Science

PubMed
Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in ASD patients from the Japanese population

Tzuyao Lo, Itaru Kushima, Branko Aleksic, Hidekazu Kato, Yoshihiro Nawa, Yu Hayashi, Gantsooj Otgonbayar, Hiroki Kimura, Yuko Arioka, Daisuke Mori, Norio Ozaki

International Review of Psychiatry Vol. 34 ( 2 ) page： 154 - 167 2022.2

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Informa UK Limited

DOI： 10.1080/09540261.2022.2072193

Web of Science

PubMed
High-power laser experiment forming a supercritical collisionless shock in a magnetized uniform plasma at rest

Yamazaki R., Matsukiyo S., Morita T., Tanaka S. J., Umeda T., Aihara K., Edamoto M., Egashira S., Hatsuyama R., Higuchi T., Hihara T., Horie Y., Hoshino M., Ishii A., Ishizaka N., Itadani Y., Izumi T., Kambayashi S., Kakuchi S., Katsuki N., Kawamura R., Kawamura Y., Kisaka S., Kojima T., Konuma A., Kumar R., Minami T., Miyata I, Moritaka T., Murakami Y., Nagashima K., Nakagawa Y., Nishimoto T., Nishioka Y., Ohira Y., Ohnishi N., Ota M., Ozaki N., Sano T., Sakai K., Sei S., Shiota J., Shoji Y., Sugiyama K., Suzuki D., Takagi M., Toda H., Tomita S., Tomiya S., Yoneda H., Takezaki T., Tomita K., Kuramitsu Y., Sakawa Y.

PHYSICAL REVIEW E Vol. 105 ( 2 ) page： 025203 2022.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1103/PhysRevE.105.025203

Web of Science

PubMed
Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses

Janos L. Kalman, Tomoya Yoshida, Till F. M. Andlauer, Eva C. Schulte, Kristina Adorjan, Martin Alda, Raffaela Ardau, Jean-Michel Aubry, Katharina Brosch, Monika Budde, Caterina Chillotti, Piotr M. Czerski, Raymond J. DePaulo, Andreas Forstner, Fern, o S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Dominik Grotegerd, Tim Hahn, Maria Heilbronner, Rol, Hasler, Urs Heilbronner, Stefanie Heilmann-Heimbach, Pawel Kapelski, Tadafumi Kato, Mojtaba Oraki Kohshour, Susanne Meinert, Tina Meller, Igor Nenadi{\'{c } }, Markus M. Nöthen, Tomas Novak, Nils Opel, Joanna Pawlak, Julia-Katharina Pfarr, James B. Potash, Daniela Reich-Erkelenz, Jonathan Repple, H{\'{e } }l{\`{e } }ne Richard-Lepouriel, Marcella Rietschel, Kai G. Ringwald, Guy Rouleau, Sabrina Schaupp, Fanny Senner, Giovanni Severino, Alessio Squassina, Frederike Stein, Pavla Stopkova, Fabian Streit, Katharina Thiel, Florian Thomas-Odenthal, Gustavo Turecki, Joanna Twarowska-Hauser, Alex, ra Winter, Peter P. Z, i, John R. Kelsoe, Bernhard T. Baune, Jan Fullerton, Philip B. Mitchell, Peter R. Schofield, Naomi R. Wray, Adam Wright, Susanne A. Bengesser, Eva Reininghaus, Claudio E. M. Banzato, Clarissa Dantas, Martin Alda, Cristiana Cruceanu, Julie Garnham, Paul Grof, Glenda MacQueen, Guy Rouleau, Claire Slaney, Gustavo Turecki, L. Trevor Young, Carlos A. L{\'{o } }pez Jaramillo, Tom{\'{a } }s Nov{\'{a } }k, Pavla Stopkova, Clara Brichant-Petitjean, Mazda Adli, S{\'{e } }bastien Gard, Bruno Etain, St{\'{e } }phane Jamain, Jean-Pierre Kahn, Marion Leboyer, Mazda Adli, Michael Bauer, Sven Cichon, Franziska Degenhardt, Peter Falkai, Oliver Gruber, Urs Heilbronner, Per Hoffmann, Sarah Kittel-Schneider, Markus Nöthen, Andrea Pfennig, Daniela Reich-Erkelenz, Andreas Reif, Marcella Rietschel, Thomas G. Schulze, Florian Seemüller, Thomas Stamm, Raffaella Ardau, Caterina Chillotti, Maria Del Zompo, Mario Maj, Mirko Manchia, Palmiero Monteleone, Giovanni Severino, Alessio Squassina, Alfonso Tortorella, Kazufumi Akiyama, Kazufumi Akiyama, Ryota Hashimoto, Tadafumi Kato, Ichiro Kusumi, Takuya Masui Takuya Masui, Norio Ozaki, Piotr Czerski, Joanna Hauser, Sebastian Kliwicki, Janusz K. Rybakowski, Maria Grigoroiu-Serbanescu, Alex, ru Obregia, B{\'{a } }rbara Arias, Antonio Benabarre, Francesc Colom, Esther Jim{\'{e } }nez, Marina Mitjans, Eduard Vieta, Lena Backlund, Lena Backlund, Louise Fris{\'{e } }n, Catharina Lavebratt, Lina Martinsson, Urban Ösby, Martin Schalling, Jean-Michel Aubry, Sven Cichon, Alex, re Dayer, Per Hoffmann, Audrey Nallet, Hsi-Chung Chen, David Cousins, Nirmala Akula, Joanna M. Biernacka, Joanna M. Biernacka, Elise T. Bui, J. Ray DePaulo, Sevilla D. Detera-Wadleigh, Mark A. Frye, Fern, o S. Goes, Rebecca Hoban, Liping Hou, Layla Kassem, John R. Kelsoe, John R. Kelsoe, Gonzalo Laje, Gonzalo Laje, Susan G. Leckb, Michael J. McCarthy, Francis J. McMahon, Roy H. Perlis, James B. Potash, Thomas G. Schulze, Barbara Schweizer, Lisa R. Seymour, Jordan W. Smoller, Jo Steele, Sarah Tighe, Peter P. Z, i, Eva Reininghaus, Claudio E. M. Banzato, Clarissa Dantas, Martin Alda, Cristiana Cruceanu, Julie Garnham, Paul Grof, Glenda MacQueen, Guy Rouleau, Claire Slaney, Gustavo Turecki, L. Trevor Young, Carlos A. L{\'{o } }pez Jaramillo, Tom{\'{a } }s Nov{\'{a } }k, Pavla Stopkova, Clara Brichant-Petitjean, Bruno Etain, Mazda Adli, S{\'{e } }bastien Gard, St{\'{e } }phane Jamain, Jean-Pierre Kahn, Marion Leboyer, Mazda Adli, Michael Bauer, Sven Cichon, Franziska Degenhardt, Peter Falkai, Oliver Gruber, Urs Heilbronner, Per Hoffmann, Sarah Kittel-Schneider, Markus Nöthen, Andrea Pfennig, Daniela Reich-Erkelenz, Andreas Reif, Marcella Rietschel, Thomas G. Schulze, Florian Seemüller, Thomas Stamm, Raffaella Ardau, Caterina Chillotti, Maria Del Zompo, Maria Del Zompo, Mario Maj, Mirko Manchia, Palmiero Monteleone, Giovanni Severino, Alessio Squassina, Alfonso Tortorella, Kazufumi Akiyama, Ryota Hashimoto, Ichiro Kusumi, Takuya Masui, Norio Ozaki, Piotr Czerski, Joanna Hauser, Sebastian Kliwicki, Janusz K. Rybakowski, Maria Grigoroiu-Serbanescu, Alex, ru Obregia, B{\'{a } }rbara Arias, Antonio Benabarre, Francesc Colom, Esther Jim{\'{e } }nez, Marina Mitjans, Eduard Vieta, Lena Backlund, Louise Fris{\'{e } }n, Catharina Lavebratt, Lina Martinsson, Urban Ösby, Martin Schalling, Jean-Michel Aubry, Sven Cichon, Alex, re Dayer, Per Hoffmann, Audrey Nallet, Hsi-Chung Chen, David Cousins, Nirmala Akula, Joanna M. Biernacka, Elise T. Bui, J. Ray DePaulo, Sevilla D. Detera-Wadleigh, Mark A. Frye, Fern, o S. Goes, Rebecca Hoban, Liping Hou, Layla Kassem, John R. Kelsoe, Gonzalo Laje, Susan G. Leckb, Michael J. McCarthy, Francis J. McMahon, Roy H. Perlis, James B. Potash, Thomas G. Schulze, Barbara Schweizer, Lisa R. Seymour, Jordan W. Smoller, Jo Steele, Sarah Tighe, Peter P. Z, i, Peter Falkai, Udo Dannlowski, Tilo Kircher, Thomas G. Schulze, Sergi Papiol

European Archives of Psychiatry and Clinical Neuroscience 2022.2

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media {LLC}

<jats:title>Abstract</jats:title><jats:p>Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (<jats:italic>N </jats:italic>= 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.</jats:p>

DOI： 10.1007/s00406-021-01366-5
Associations Among Maternal Metabolic Conditions, Cord Serum Leptin Levels, and Autistic Symptoms in Children

Toshiki Iwabuchi, Nagahide Takahashi, Tomoko Nishimura, Md Shafiur Rahman, Taeko Harada, Akemi Okumura, Hitoshi Kuwabara, Shu Takagai, Yoko Nomura, Hideo Matsuzaki, Norio Ozaki, Kenji J. Tsuchiya

Frontiers in Psychiatry Vol. 12 page： 816196 2022.2

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Frontiers Media SA

Introduction

Accumulating evidence has shown that maternal metabolic conditions, such as pre-pregnancy overweight, diabetes mellitus, and hypertensive disorders of pregnancy (HDP) are potential risk factors of autism spectrum disorder (ASD). However, it remains unclear how these maternal conditions lead to neurodevelopmental outcomes in the offspring, including autistic symptoms. Leptin, an adipokine that has pro-inflammatory effects and affects fetal neurodevelopment, is a candidate mediator of the association between maternal metabolic factors and an increased risk of ASD. However, whether prenatal exposure to leptin mediates the association between maternal metabolic conditions and autistic symptoms in children has not been investigated yet.

Methods

This study investigated the associations between mothers' metabolic conditions (pre-pregnancy overweight, diabetes mellitus during or before pregnancy, and HDP), leptin concentrations in umbilical cord serum, and autistic symptoms among 762 children from an ongoing cohort study, using generalized structural equation modeling. We used the Social Responsive Scale, Second Edition (SRS-2) at 8–9 years old to calculate total T-scores. Additionally, we used the T-scores for two subdomains: Social Communication and Interaction (SCI) and Restricted Interests and Repetitive Behavior (RRB).

Results

Umbilical cord leptin levels were associated with pre-pregnancy overweight [coefficient = 1.297, 95% confidence interval (CI) 1.081–1.556, p = 0.005] and diabetes mellitus (coefficient = 1.574, 95% CI 1.206–2.055, p = 0.001). Furthermore, leptin levels were significantly associated with SRS-2 total T-scores (coefficient = 1.002, 95% CI 1.000–1.004, p = 0.023), SCI scores (coefficient = 1.002, 95% CI 1.000–1.004, p = 0.020), and RRB scores (coefficient = 1.001, 95% CI 1.000–1.003, p = 0.044) in children. Associations between maternal metabolic factors and autistic symptoms were not significant.

Discussion

The present study uncovered an association between cord leptin levels and autistic symptoms in children, while maternal metabolic conditions did not have an evident direct influence on the outcome. These results imply that prenatal pro-inflammatory environments affected by maternal metabolic conditions may contribute to the development of autistic symptoms in children. The findings warrant further investigation into the role of leptin in the development of autistic symptoms.

DOI： 10.3389/fpsyt.2021.816196

Web of Science

PubMed
Magnetic resonance–guided focused ultrasound thalamotomy restored distinctive resting-state networks in patients with essential tremor International journal

Sachiko Kato, Satoshi Maesawa, Epifanio Bagarinao, Daisuke Nakatsubo, Takahiko Tsugawa, Satomi Mizuno, Kazuya Kawabata, Takashi Tsuboi, Masashi Suzuki, Masashi Shibata, Sou Takai, Tomotaka Ishizaki, Jun Torii, Manabu Mutoh, Ryuta Saito, Toshihiko Wakabayashi, Masahisa Katsuno, Norio Ozaki, Hirohisa Watanabe, Gen Sobue

Journal of Neurosurgery Vol. 138 ( 2 ) page： 306 - 317 2022.2

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Neurosurgery Publishing Group (JNSPG)

OBJECTIVE

Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy ameliorates symptoms in patients with essential tremor (ET). How this treatment affects canonical brain networks has not been elucidated. The purpose of this study was to clarify changes of brain networks after MRgFUS thalamotomy in ET patients by analyzing resting-state networks (RSNs).

METHODS

Fifteen patients with ET were included in this study. Left MRgFUS thalamotomy was performed in all cases, and MR images, including resting-state functional MRI (rsfMRI), were taken before and after surgery. MR images of 15 age- and sex-matched healthy controls (HCs) were also used for analysis. Using rsfMRI data, canonical RSNs were extracted by performing dual regression analysis, and the functional connectivity (FC) within respective networks was compared among pre-MRgFUS patients, post-MRgFUS patients, and HCs. The severity of tremor was evaluated using the Clinical Rating Scale for Tremor (CRST) score pre- and postoperatively, and its correlation with RSNs was examined.

RESULTS

Preoperatively, ET patients showed a significant decrease in FC in the sensorimotor network (SMN), primary visual network (VN), and visuospatial network (VSN) compared with HCs. The decrease in FC in the SMN correlated with the severity of tremor. After MRgFUS thalamotomy, ET patients still exhibited a significant decrease in FC in a small area of the SMN, but they exhibited an increase in the cerebellar network (CN). In comparison between pre- and post-MRgFUS patients, the FC in the SMN and the VSN significantly increased after treatment. Quantitative evaluation of the FCs in these three groups showed that the SMN and VSN increased postoperatively and demonstrated a trend toward those of HCs.

CONCLUSIONS

The SMN and CN, which are considered to be associated with the cerebello-thalamo-cortical loop, exhibited increased connectivity after MRgFUS thalamotomy. In addition, the FC of the visual network, which declined in ET patients compared with HCs, tended to normalize postoperatively. This could be related to the hypothesis that visual feedback is involved in tremor severity in ET patients. Overall, the analysis of the RSNs by rsfMRI reflected the pathophysiology with the intervention of MRgFUS thalamotomy in ET patients and demonstrated a possibility of a biomarker for successful treatment.

DOI： 10.3171/2022.5.JNS22411

Web of Science

PubMed

Other Link： https://thejns.org/downloadpdf/journals/j-neurosurg/aop/article-10.3171-2022.5.JNS22411/article-10.3171-2022.5.JNS22411.xml
Perceived Social Support Partially Mediates the Impact of Temperament and Character on Postpartum Depression

Yukako Nakamura, Nagahide Takahashi, Aya Yamauchi, Mako Morikawa, Takashi Okada, Norio Ozaki

Frontiers in Psychiatry Vol. 12 page： 816342 2022.1

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Frontiers Media SA

<sec><title>Introduction</title>Temperament and character of pregnant women, especially harm avoidance (HA) and self-directedness (SD) have been identified as risk factors for postpartum depression, in addition to poor social support. However, the relationship between these personality traits and social support for depressive symptoms after delivery has not been examined.

</sec><sec><title>Methods</title>Data were extracted from a prospective cohort survey on pregnant women conducted in Nagoya, Japan that included the Temperament and Character Inventory (TCI), the Social Support Questionnaire (J-SSQ), and the Edinburgh Postnatal Depression Scale (EPDS) at approximately week 25 and 1 month postpartum. A mediation analysis using structural equation modeling (SEM) was used to test if social support in pregnancy is a mediator between personality traits and postpartum depressive symptoms.

</sec><sec><title>Results</title>Thousand five hundred and fifty-nine women were included in the analysis. Both harm avoidance and SD were significantly associated with depressive symptoms (total effect: β [SE], 0.298 [0.041], <italic>P</italic> &lt; 0.001 for harm avoidance; total effect: β [SE], −0.265 [0.067], <italic>P</italic> &lt; 0.001 for SD). Mediation analysis showed that the effect of harm avoidance on depressive symptoms was partially mediated by low social support (direct effect: β [SE], 0.193 [0.004], <italic>P</italic> &lt; 0.001; indirect effect: β [SE], 0.082 [0.034], <italic>P</italic> = 0.015). Self-directedness on depressive symptoms was not found to be mediated by low social support.

</sec><sec><title>Conclusion</title>Results indicate that poor social support worsens depressive symptoms in women with high HA during pregnancy. Limitations include a possible selection bias due to the limited target facilities; most variables being evaluated based on self-report questionnaires, and different number of samples available for analysis between harm avoidance and SD.

</sec>

DOI： 10.3389/fpsyt.2021.816342

Web of Science

PubMed
Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks

Jingzhu Liao, Geyao Dong, Bolati Wulaer, Masahito Sawahata, Hiroyuki Mizoguchi, Daisuke Mori, Norio Ozaki, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada

Behavioural Brain Research Vol. 416 page： 113569 - 113569 2022.1

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.bbr.2021.113569

PubMed
Autism spectrum disorder comorbid with obsessive compulsive disorder and eating disorder in a woman with NBEA deletion.

Kato H, Kushima I, Yoshimi A, Ishizuka K, Kimura H, Aleksic B, Takahashi N, Okada T, Ozaki N

Psychiatry and clinical neurosciences Vol. 76 ( 1 ) page： 36 - 38 2022.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.13309

PubMed
Trends in big data analyses by multicenter collaborative translational research in psychiatry. Reviewed International journal

Toshiaki Onitsuka, Yoji Hirano, Kiyotaka Nemoto, Naoki Hashimoto, Itaru Kushima, Daisuke Koshiyama, Michihiko Koeda, Tsutomu Takahashi, Yoshihiro Noda, Junya Matsumoto, Kenichiro Miura, Takanobu Nakazawa, Takatoshi Hikida, Kiyoto Kasai, Norio Ozaki, Ryota Hashimoto

Psychiatry and clinical neurosciences Vol. 76 ( 1 ) page： 1 - 14 2022.1

　More details

Language：English Publishing type：Research paper (scientific journal)

The underlying pathologies of psychiatric disorders, which cause substantial personal and social losses, remain unknown, and their elucidation is an urgent issue. To clarify the core pathological mechanisms underlying psychiatric disorders, in addition to laboratory-based research that incorporates the latest findings, it is necessary to conduct large-sample-size research and verify reproducibility. For this purpose, it is critical to conduct multicenter collaborative research across various fields, such as psychiatry, neuroscience, molecular biology, genomics, neuroimaging, cognitive science, neurophysiology, psychology and pharmacology. Moreover, collaborative research plays an important role in the development of young researchers. In this respect, the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium and Cognitive Genetics Collaborative Research Organization (COCORO) have played important roles. In this review, we first overview the importance of multicenter collaborative research and our target psychiatric disorders. Then, we introduce research findings on the pathophysiology of psychiatric disorders from neurocognitive, neurophysiological, neuroimaging, genetic, and basic neuroscience perspectives, focusing mainly on the findings obtained by COCORO. It is our hope that multicenter collaborative research will contribute to the elucidation of the pathological basis of psychiatric disorders. This article is protected by copyright. All rights reserved.

DOI： 10.1111/pcn.13311

Web of Science

PubMed
Clinical guide for women with mental health problems during the perinatal period International journal

Koichiro Shimoya, Tomomi Kotani, Shoji Satoh, Shunji Suzuki, Haruo Kashima, Kazuyoshi Ogasawara, Norio Ozaki, Eiji Suzuki, Yoshiyuki Tachibana, Toshihito Suzuki

Journal of Obstetrics and Gynaecology Research Vol. 48 ( 1 ) page： 20 - 33 2022.1

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Pregnancy and childbirth have various effects on the physical as well as mental aspects of women. Therefore, appropriate considerations must be given to the mental health of pregnant women. The Guideline Review Committee of the Japanese Society of Psychiatry and Neurology launched a liaison meeting for the Japanese Society of Psychiatry and Neurology and the Japan Society of Obstetrics and Gynecology, with a view to creating a "Clinical guide for women with mental health problems during the perinatal period" by cooperation of these two fields. After repeated discussions with input from both academic societies, they jointly formulated the "Clinical guide for women with mental health problems during the perinatal period: Overview" in May 2020, and reported its "Detailed Contents" in April 2021. We hope that this guide, which is the English overview of the detailed guide, will contribute to the mental health of pregnant women, facilitating healthy pregnancies and childbirth.

DOI： 10.1111/jog.15068

PubMed

Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jog.15068
A Study of Factors Causing Sleep State Misperception in Patients with Depression. International journal

Keita Kawai, Kunihiro Iwamoto, Seiko Miyata, Ippei Okada, Motoo Ando, Hiroshige Fujishiro, Akiko Noda, Norio Ozaki

Nature and science of sleep Vol. 14 page： 1273 - 1283 2022

　More details

Language：English Publishing type：Research paper (scientific journal)

Purpose: Sleep state misperception, which is the discrepancy between subjective and objective sleep, is often observed in patients with depression. This phenomenon may delay the remission of depression. Previous studies have focused on the total sleep time (TST) misperception, with many of these studies using actigraphy. Thus, our study investigated depressed patients with the exploratory aim of clarifying factors associated with the sleep state misperception including the wake after sleep onset (WASO) misperception, with their objective sleep additionally evaluated by polysomnography (PSG). Patients and Methods: We conducted a cross-sectional study. Before undergoing overnight PSG monitoring, 40 patients with depression completed questionnaires that included the Beck Depression Inventory (BDI), Epworth sleepiness scale, Temperament and Character Inventory, and the Pittsburgh sleep quality index. Patients were also asked to estimate their subjective sleep duration after they woke up in the morning. Based on this data, we calculated the misperception using the following formula: subjective sleep duration minus objective sleep duration. We compared each factor between negative and positive misperception groups and the multiple regression analysis was performed for TST and WASO misperception, respectively. Results: Although sleep architectures, age, severity of depression and obstructive sleep apnea (OSA) exhibited differences in underestimating or overestimating the WASO, only sex differences were associated with underestimating or overestimating their total sleep time (TST). Moreover, BDI, the severity of OSA, sleep architectures (N1% and N2%), and benzodiazepine (BZD) use were significantly correlated with WASO misperception, whereas only OSA severity was significantly correlated with TST misperception. A subsequent multiple regression analysis demonstrated the BDI was independently correlated with the WASO misperception (β=0.341, p=0.049). Conclusion: In clinical practice, interventions especially for OSA, and the reduction of depressive symptoms are an important method for improving patient sleep perception. Moreover, current results suggest that BZD prescriptions should be avoided as well.

DOI： 10.2147/NSS.S366774

Web of Science

PubMed
Reserve and maintenance in the aging brain: A longitudinal study of healthy older adults. International journal

Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Kazuya Kawabata, Kazuhiro Hara, Reiko Ohdake, Aya Ogura, Daisuke Mori, Noritaka Yoneyama, Kazunori Imai, Takamasa Yokoi, Toshiyasu Kato, Shuji Koyama, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

eNeuro Vol. 9 ( 1 ) 2022

　More details

Language：English Publishing type：Research paper (scientific journal)

The aging brain undergoes structural changes even in very healthy individuals. Quantifying these changes could help disentangle pathological changes from those associated with the normal human aging process. Using longitudinal MRI data from 227 carefully selected healthy human cohort with age ranging from 50 to 80 years old at baseline scan, we quantified age-related volumetric changes in the brain of healthy human older adults. Longitudinally, the rates of tissue loss in total gray matter (GM) and white matter were 2,497.5 mm3 per year and 2,579.8 mm3 per year, respectively. Across the whole brain, the rates of GM decline varied with regions in the frontal and parietal lobes having faster rates of decline, whereas some regions in the occipital and temporal lobes appeared relatively preserved. In contrast, cross sectional changes were mainly observed in the temporal-occipital regions. Similar longitudinal atrophic changes were also observed in subcortical regions including thalamus, hippocampus, putamen, and caudate, whereas the pallidum showed an increasing volume with age. Overall, regions maturing late in development (frontal, parietal) are more vulnerable to longitudinal decline, whereas those that fully mature in the early stage (temporal, occipital) are mainly affected by cross sectional changes in healthy older cohort. This may suggest that, for a successful healthy aging, the former needs to be maximally developed at an earlier age to compensate for the longitudinal decline later in life and the latter to remain relatively preserved even in old age, consistent with both concepts of reserve and brain maintenance.Significance StatementAging is associated with gray matter (GM) decline, yet some individuals tend to remain cognitively healthy even in advanced age. What differentiates the brains of "healthy agers" from those individuals who are prone to faster cognitive decline still remains unclear. Using longitudinal MRI data from a carefully selected cohort, we examined the brain aging characteristics of healthy agers. Our findings showed that, even in this population, frontal-parietal regions have faster longitudinal rate of GM decline, whereas some temporal-occipital regions appeared relatively preserved. These findings may suggest that, for a successful healthy aging, frontal-parietal regions need to be maximally developed to compensate for the longitudinal decline later in life and the temporal-occipital regions to remain relatively preserved even in old age.

DOI： 10.1523/ENEURO.0455-21.2022

Web of Science

PubMed
Involvement of cerebellar and subcortical connector hubs in schizophrenia

Yamamoto Maeri, Bagarinao Epifanio, Shimamoto Masanori, Iidaka Tetsuya, Ozaki Norio

NEUROIMAGE-CLINICAL Vol. 35 page： 103140 2022

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.nicl.2022.103140

Web of Science

PubMed
Exonic deletions in IMMP2L in schizophrenia with enhanced glycation stress subtype International journal

Akane Yoshikawa, Itaru Kushima, Mitsuhiro Miyashita, Kazuhiro Suzuki, Kyoka Iino, Kazuya Toriumi, Yasue Horiuchi, Hideya Kawaji, Norio Ozaki, Masanari Itokawa, Makoto Arai

PLOS ONE Vol. 17 ( 7 ) page： e0270506 - e0270506 2022

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Public Library of Science (PLoS)

We previously identified a subtype of schizophrenia (SCZ) characterized by increased plasma pentosidine, a marker of glycation and oxidative stress (PEN-SCZ). However, the genetic factors associated with PEN-SCZ have not been fully clarified. We performed a genome-wide copy number variation (CNV) analysis to identify CNVs associated with PEN-SCZ to provide an insight into the novel therapeutic targets for PEN-SCZ. Plasma pentosidine was measured by high-performance liquid chromatography in 185 patients with SCZ harboring rare CNVs detected by array comparative genomic hybridization. In three patients with PEN-SCZ showing additional autistic features, we detected a novel deletion at 7q31.1 within exons 2 and 3 of IMMP2L, which encodes the inner mitochondrial membrane peptidase subunit 2. The deletion was neither observed in non-PEN-SCZ nor in public database of control subjects. IMMP2L is one of the SCZ risk loci genes identified in a previous SCZ genome-wide association study, and its trans-populational association was recently described. Interestingly, deletions in IMMP2L have been previously linked with autism spectrum disorder. Disrupted IMMP2L function has been shown to cause glycation/oxidative stress in neuronal cells in an age-dependent manner. To our knowledge, this is the first genome-wide CNV study to suggest the involvement of IMMP2L exons 2 and 3 in the etiology of PEN-SCZ. The combination of genomic information with plasma pentosidine levels may contribute to the classification of biological SCZ subtypes that show additional autistic features. Modifying IMMP2L functions may be useful for treating PEN-SCZ if the underlying biological mechanism can be clarified in further studies.

DOI： 10.1371/journal.pone.0270506

PubMed
Exome sequencing of Japanese schizophrenia multiplex families supports the involvement of calcium ion channels International journal

Miho Toyama, Yuto Takasaki, Aleksic Branko, Hiroki Kimura, Hidekazu Kato, Yoshihiro Nawa, Itaru Kushima, Kanako Ishizuka, Teppei Shimamura, Tomoo Ogi, Norio Ozaki

PLOS ONE Vol. 17 ( 5 ) page： e0268321 - e0268321 2022

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Public Library of Science (PLoS)

Background

Most sequencing studies of schizophrenia (SCZ) have focused on de novo genetic variants due to interpretability. However, investigating shared rare variants among patients in the same multiplex family is also important. Relatively large-scale analyses of SCZ multiplex families have been done in Caucasian populations, but whether detected variants are also pathogenic in the Japanese population is unclear because of ethnic differences in rare variants.

Materials and methods

We performed whole-exome sequencing (WES) of 14 Japanese SCZ multiplex families. After quality control and filtering, we identified rare variants shared among affected persons within the same family. A gene ontology (GO) analysis was performed to identify gene categories possibly affected by these candidate variants.

Results

We found 530 variants in 486 genes as potential candidate variants from the 14 SCZ multiplex families examined. The GO analysis demonstrated significant enrichment in calcium channel activity.

Conclusion

This study provides supporting evidence that calcium ion channel activity is involved in SCZ. WES of multiplex families is a potential means of identifying disease-associated rare variants for SCZ.

DOI： 10.1371/journal.pone.0268321

Web of Science

PubMed
Association between effect of duloxetine on chronic orofacial pain and expression of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia

Mariko Nakamura, Yoshimi Akira, Mouri Akihiro, Tokura Tatsuya, Kimura Hiroyuki, Kishi Shinichi, Miyauchi Tomoya, Iwamoto Kunihiro, Ito Mikiko, Sato Aiji, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro

Proceedings for Annual Meeting of The Japanese Pharmacological Society Vol. 95 page： 1-P-081 2022

　More details

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Pharmacological Society

Introduction: Burning mouth syndrome and atypical odontalgia (BMS/AO) are chronic orofacial pain conditions in the absence of any identifiable odontogenic pathology. The pain is treatment-resistant and frequently causes depressive symptoms. Duloxetine (DLX), a serotonin-noradrenaline reuptake inhibitor, is not only used as therapy for depression, but also for chronic orofacial pain. Since their mechanisms in detail remains unknown, in this study, we focused on serotonin transporter (SERT), one of DLX action site, and investigated association between expression of SERT and effect of DLX on pain in BMS/AO.

Methods: The patients with BMS/AO, were assessed for severity of pain using the visual analog scale (VAS) and for signs of depression using the Hamilton Depression Rating Scale (HDRS). In their platelets before (baseline) and 12 weeks after DLX-treatment, the expression of total and ubiquitinated SERT proteins was confirmed by Western blot. This study was approved by the Ethics Review Committees of Nagoya, Aichi Gakuin, and Meijo Universities.

Results: The expression of total and ubiquitinated SERT protein at baseline in all patients were higher and lower, respectively, compared to those in controls. After the DLX-treatment, there was no difference in the total SERT protein levels between the patients and controls. The mean of VAS and HDRS scores or the expression of total SERT protein were significantly decreased after the treatment, compared to those at baseline.

Conclusions: These results indicate that DLX relieves chronic orofacial pain in patients with BMS/AO, and such effect may be mediated via SERT downregulation.

DOI： 10.1254/jpssuppl.95.0_1-p-081
Patient characteristics affecting accurate detection of sleep apnea using a bed sheet-type portable monitor.

Miyata S, Otake H, Ando M, Okuda M, Fujishiro H, Iwamoto K, Noda A, Sone M, Ozaki N

Sleep & breathing = Schlaf & Atmung 2019.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s11325-019-01963-8

PubMed
Cutting edge morphological studies of postmortem brains of patients with schizophrenia and potential applications of X-ray nanotomography (nano-CT).

Itokawa M, Oshima K, Arai M, Torii Y, Kushima I, Iritani S, Ozaki N, Saiga R, Mizutani R

Psychiatry and clinical neurosciences 2019.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12957

PubMed
Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome

Baba Masayuki, Yokoyama Kazumasa, Seiriki Kaoru, Naka Yuichiro, Matsumura Kensuke, Kondo Momoka, Yamamoto Kana, Hayashida Misuzu, Kasai Atsushi, Ago Yukio, Nagayasu Kazuki, Hayata-Takano Atsuko, Takahashi Akinori, Yamaguchi Shun, Mori Daisuke, Ozaki Norio, Yamamoto Tadashi, Takuma Kazuhiro, Hashimoto Ryota, Hashimoto Hitoshi, Nakazawa Takanobu

NEUROPSYCHOPHARMACOLOGY Vol. 44 ( 12 ) page： 2125-2135 2019.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41386-019-0441-5

Web of Science

PubMed
POLYGENIC RISK SCORES IN SCHIZOPHRENIA WITH CLINICALLY SIGNIFICANT COPY NUMBER VARIANTS

Taniguchi Satoru, Ninomiya Kohei, Kushima Itaru, Okochi Tomo, Saito Takeo, Shimasaki Ayu, Sakusabe Takaya, Momozawa Yukihide, Kubo Michiaki, Kamatani Yoichiro, Ozaki Norio, Ikeda Masashi, Iwata Nakao

EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 29 page： S212-S212 2019.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.euroneuro.2019.08.184

Web of Science
Clinicopathological differences between the motor onset and psychiatric onset of Huntington's disease, focusing on the nucleus accumbens

Hirano Mitsuaki, Iritani Shuji, Fujishiro Hiroshige, Torii Youta, Habuchi Chikako, Sekiguchi Hirotaka, Yoshida Mari, Ozaki Norio

NEUROPATHOLOGY Vol. 39 ( 5 ) page： 331-341 2019.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/neup.12578

Web of Science

PubMed
A battery of self-screening instruments and self-reported body frame could not detect eating disorders among college students.

Hayakawa N, Tanaka S, Hirata N, Ogino S, Ozaki N

BMC research notes Vol. 12 ( 1 ) page： 613 2019.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s13104-019-4672-7

PubMed
In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of PCDH15 and RELN

Ishii, T. Ishikawa, M. Fujimori, K. Maeda, T. Kushima, I. Arioka, Y. Mori, D. Nakatake, Y. Yamagata, B. Nio, S. Kato, T. A. Yang, N. Wernig, M. Kanba, S. Mimura, M. Ozaki, N. Okano, H.

eNeuro 2019.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： doi.org/10.1523/ENEURO.0403-18.2019
Reorganization of brain networks and its association with general cognitive performance over the adult lifespan

Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Taoka Toshiaki, Koyama Shuji, Tanabe Hiroki C., Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Ozaki Norio, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Sobue Gen

SCIENTIFIC REPORTS Vol. 9 ( 1 ) page： 11352 2019.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41598-019-47922-x

Web of Science

PubMed
Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms

Teshigawara Tomoaki, Mouri Akihiro, Kubo Hisako, Nakamura Yukako, Shiino Tomoko, Okada Takashi, Morikawa Mako, Nabeshima Toshitaka, Ozaki Norio, Yamamoto Yasuko, Saito Kuniaki

JOURNAL OF AFFECTIVE DISORDERS Vol. 255 page： 168-176 2019.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jad.2019.05.028

Web of Science

PubMed
Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration

Uchida Mizuki, Hida Hirotake, Mori Kentaro, Yoshimi Akira, Kitagaki Shinji, Yamada Kiyofumi, Hiraoka Yuichi, Aida Tomomi, Tanaka Kohichi, Ozaki Norio, Noda Yukihiro

EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 29 ( 8 ) page： 914-924 2019.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.euroneuro.2019.06.005

Web of Science

PubMed
Clinical profiles of late-onset psychiatric patients exhibiting incidental REM sleep without atonia

Fujishiro Hiroshige, Okuda Masato, Iwamoto Kunihiro, Miyata Seiko, Torii Youta, Iritani Shuji, Ozaki Norio

JOURNAL OF NEURAL TRANSMISSION Vol. 126 ( 8 ) page： 1095-1104 2019.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00702-019-02035-7

Web of Science

PubMed
Relation Between Perinatal Depressive Symptoms, Harm Avoidance, and a History of Major Depressive Disorder: A Cohort Study of Pregnant Women in Japan

Kubota Chika, Inada Toshiya, Shiino Tomoko, Ando Masahiko, Aleksic Branko, Yamauchi Aya, Sato Maya, Ohara Masako, Murase Satomi, Morikawa Mako, Nakamura Yukako, Okada Takashi, Goto Setsuko, Kanai Atsuko, Ozaki Norio

FRONTIERS IN PSYCHIATRY Vol. 10 page： 515 2019.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3389/fpsyt.2019.00515

Web of Science

PubMed
Effects of sleep-disordered breathing and hypertension on cognitive function in elderly adults

Kato Kazuko, Noda Akiko, Yasuma Fumihiko, Matsubara Yuka, Miyata Seiko, Iwamoto Kunihiro, Miyazaki Soichiro, Ozaki Norio

CLINICAL AND EXPERIMENTAL HYPERTENSION page： 1-7 2019.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1080/10641963.2019.1632338

Web of Science

PubMed
Quantitative facial expression analysis revealed the efficacy and time course of oxytocin in autism

Owada Keiho, Okada Takashi, Munesue Toshio, Kuroda Miho, Fujioka Toru, Uno Yota, Matsumoto Kaori, Kuwabara Hitoshi, Mori Daisuke, Okamoto Yuko, Yoshimura Yuko, Kawakubo Yuki, Arioka Yuko, Kojima Masaki, Yuhi Teruko, Yassin Walid, Kushima Itaru, Benner Seico, Ogawa Nanayo, Kawano Naoko, Eriguchi Yosuke, Uemura Yukari, Yamamoto Maeri, Kano Yukiko, Kasai Kiyoto, Higashida Haruhiro, Ozaki Norio, Kosaka Hirotaka, Yamasue Hidenori

BRAIN Vol. 142 ( 7 ) page： 2127-2136 2019.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/brain/awz126

Web of Science

PubMed
Effect of antidepressant treatment on plasma levels of neuroinflammation-associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region

Miyauchi Tomoya, Tokura Tatsuya, Kimura Hiroyuki, Ito Mikiko, Umemura Eri, Sato (Bokuj) Aiji, Nagashima Wataru, Tonoike Takashi, Yamamoto Yasuko, Saito Kuniaki, Kurita Kenichi, Ozaki Norio

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 34 ( 4 ) page： e2698 2019.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.2698

Web of Science

PubMed
Methylation analysis for postpartum depression: a case control study

Nakamura Yukako, Nakatochi Masahiro, Kunimoto Shohko, Okada Takashi, Aleksic Branko, Toyama Miho, Shiino Tomoko, Morikawa Mako, Yamauchi Aya, Yoshimi Akira, Furukawa-Hibi Yoko, Nagai Taku, Ohara Masako, Kubota Chika, Yamada Kiyofumi, Ando Masahiko, Ozaki Norio

BMC PSYCHIATRY Vol. 19 ( 1 ) page： 190 2019.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s12888-019-2172-x

Web of Science

PubMed
Oral medicine psychiatric liaison clinic: study of 1202 patients attending over an 18-year period

Umemura E., Tokura T., Ito M., Kobayashi Y., Tachibana M., Miyauchi T., Tonoike T., Nagashima W., Kimura H., Arao M., Sato (Boku) A., Ozaki N., Kurita K.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY Vol. 48 ( 5 ) page： 644-650 2019.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.ijom.2018.12.005

Web of Science
Exploration of coping styles in male patients with head and neck cancer: a prospective cohort study

Sato Naohiro, Kimura Hiroyuki, Adachi Yasunori, Nishio Naoki, Ando Masahiko, Tokura Tatsuya, Nagashima Wataru, Kishi Shinichi, Yamauchi Aya, Yoshida Keizo, Hiramatsu Mariko, Fujimoto Yasushi, Ozaki Norio

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 81 ( 2 ) page： 249-258 2019.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.18999/nagjms.81.2.249

Web of Science

PubMed
Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients.

Yoshimi A, Yamada S, Kunimoto S, Aleksic B, Hirakawa A, Ohashi M, Matsumoto Y, Hada K, Itoh N, Arioka Y, Kimura H, Kushima I, Nakamura Y, Shiino T, Mori D, Tanaka S, Hamada S, Noda Y, Nagai T, Yamada K, Ozaki N

Translational psychiatry Vol. 9 ( 1 ) page： 126 2019.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41398-019-0461-2

PubMed
Blonanserin ameliorates social deficit through dopamine-D3 receptor antagonism in mice administered phencyclidine as an animal model of schizophrenia.

Takeuchi S, Hida H, Uchida M, Naruse R, Yoshimi A, Kitagaki S, Ozaki N, Noda Y

Neurochemistry international Vol. 128 page： 127-134 2019.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neuint.2019.04.008

PubMed
Acute administration of ketamine attenuates the impairment of social behaviors induced by social defeat stress exposure as juveniles via activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors

Hasegawa Sho, Yoshimi Akira, Mouri Akihiro, Uchida Yoji, Hida Hirotake, Mishina Masayoshi, Yamada Kiyofumi, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro

NEUROPHARMACOLOGY Vol. 148 page： 107-116 2019.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neuropharm.2018.12.020

Web of Science

PubMed
Decline of Plasma Concentrations of Interleukin-18 in Severely Malnourished Patients with Anorexia Nervosa: Exploratory Analysis

Tanaka Satoshi, Oya-Ito Tomoko, Murakami Yuki, Saito Kuniaki, Furuta Sho, Yu Yanjie, Imaeda Miho, Kunimoto Shohko, Ozaki Norio

NUTRIENTS Vol. 11 ( 3 ) 2019.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3390/nu11030540

Web of Science

PubMed
Hypochondriasis in the elderly and Lewy body disease.

Fujishiro H, Kimura H, Nakamura T, Torii Y, Iritani S, Ozaki N

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 2019.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/psyg.12425

PubMed
Three-dimensional alteration of neurites in schizophrenia

Mizutani Ryuta, Saiga Rino, Takeuchi Akihisa, Uesugi Kentaro, Terada Yasuko, Suzuki Yoshio, De Andrade Vincent, De Carlo Francesco, Takekoshi Susumu, Inomoto Chie, Nakamura Naoya, Kushima Itaru, Iritani Shuji, Ozaki Norio, Ide Soichiro, Ikeda Kazutaka, Oshima Kenichi, Itokawa Masanari, Arai Makoto

TRANSLATIONAL PSYCHIATRY Vol. 9 ( 1 ) page： 85 2019.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41398-019-0427-4

Web of Science

PubMed
Application of eye trackers for understanding mental disorders: Cases for schizophrenia and autism spectrum disorder.

Shishido E, Ogawa S, Miyata S, Yamamoto M, Inada T, Ozaki N

Neuropsychopharmacology reports 2019.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/npr2.12046

PubMed
Protocol for the development and validation of a driving simulator for evaluating the influence of drugs on driving performance

Iwata Mari, Iwamoto Kunihiro, Omura Tomohiro, Ando Masahiko, Ozaki Norio

MEDICINE Vol. 98 ( 8 ) page： e14613 2019.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/MD.0000000000014613

Web of Science

PubMed
A Network of Networks Approach for Modeling Interconnected Brain Tissue-Specific Networks.

Kawakubo H, Matsui Y, Kushima I, Ozaki N, Shimamura T

Bioinformatics (Oxford, England) 2019.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/bioinformatics/btz032

PubMed
Characterization of a schizophrenia patient with a rare RELN deletion by combining genomic and patient-derived cell analyses

Arioka, Y Hirata, A Kushima, I Aleksic, B Mori, D Ozaki, N

Schizophr Res 2019

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2019.10.038
In Vitro Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of PCDH15 and RELN

Ishii Takaya, Ishikawa Mitsuru, Fujimori Koki, Maeda Takuji, Kushima Itaru, Arioka Yuko, Mori Daisuke, Nakatake Yuhki, Yamagata Bun, Nio Shintaro, Kato Takahiro A., Yang Nan, Wernig Marius, Kanba Shigenobu, Mimura Masaru, Ozaki Norio, Okano Hideyuki

ENEURO Vol. 6 ( 5 ) 2019

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1523/ENEURO.0403-18.2019

Web of Science

PubMed
Stable factor structure of the Edinburgh Postnatal Depression Scale during the whole peripartum period: Results from a Japanese prospective cohort study

Kubota Chika, Inada Toshiya, Nakamura Yukako, Shiino Tomoko, Ando Masahiko, Aleksic Branko, Yamauchi Aya, Morikawa Mako, Okada Takashi, Ohara Masako, Sato Maya, Murase Satomi, Goto Setsuko, Kanai Atsuko, Ozaki Norio

SCIENTIFIC REPORTS Vol. 8 ( 1 ) page： 17659 2018.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41598-018-36101-z

Web of Science

PubMed
Effects of hypnotics on prefrontal cortex activity during a verbal fluency task in healthy male subjects: A near-infrared spectroscopy study

Tsuruta Yoshiyuki, Iwamoto Kunihiro, Banno Masahiro, Kawano Naoko, Kohmura Kunihiro, Miyata Seiko, Fujishiro Hiroshige, Noda Yukihiro, Noda Akiko, Iritani Shuji, Ozaki Norio

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 33 ( 6 ) page： e2678 2018.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.2678

Web of Science

PubMed
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, Shimasaki A, Kawase K, Sakusabe T, Iwayama Y, Toyota T, Wakuda T, Kikuchi M, Kanahara N, Yamamori H, Yasuda Y, Watanabe Y, Hoya S, Aleksic B, Kushima I, Arai H, Takaki M, Hattori K, Kunugi H, Okahisa Y, Ohnuma T, Ozaki N, Someya T, Hashimoto R, Yoshikawa T, Kubo M, Iwata N

Schizophrenia bulletin 2018.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/schbul/sby140

PubMed
Evaluation method regarding the effect of psychotropic drugs on driving performance: A literature review.

Iwata M, Iwamoto K, Kawano N, Kawaue T, Ozaki N

Psychiatry and clinical neurosciences Vol. 72 ( 10 ) page： 747-773 2018.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12734

PubMed
Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia.

Ishizuka K, Kimura H, Kushima I, Inada T, Okahisa Y, Ikeda M, Iwata N, Mori D, Aleksic B, Ozaki N

Psychiatric genetics Vol. 28 ( 5 ) page： 90-93 2018.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/YPG.0000000000000204

PubMed
Impact of perceived rearing and social support on bonding failure and depression among mothers: A longitudinal study of pregnant women.

Ohara M, Nakatochi M, Okada T, Aleksic B, Nakamura Y, Shiino T, Yamauchi A, Kubota C, Morikawa M, Murase S, Goto S, Kanai A, Kato R, Ando M, Ozaki N

Journal of psychiatric research Vol. 105 page： 71-77 2018.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jpsychires.2018.09.001

PubMed
Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights.

Kushima I, Aleksic B, Nakatochi M, Shimamura T, Okada T, Uno Y, Morikawa M, Ishizuka K, Shiino T, Kimura H, Arioka Y, Yoshimi A, Takasaki Y, Yu Y, Nakamura Y, Yamamoto M, Iidaka T, Iritani S, Inada T, Ogawa N, Shishido E, Torii Y, Kawano N, Omura Y, Yoshikawa T, Uchiyama T, Yamamoto T, Ikeda M, Hashimoto R, Yamamori H, Yasuda Y, Someya T, Watanabe Y, Egawa J, Nunokawa A, Itokawa M, Arai M, Miyashita M, Kobori A, Suzuki M, Takahashi T, Usami M, Kodaira M, Watanabe K, Sasaki T, Kuwabara H, Tochigi M, Nishimura F, Yamasue H, Eriguchi Y, Benner S, Kojima M, Yassin W, Munesue T, Yokoyama S, Kimura R, Funabiki Y, Kosaka H, Ishitobi M, Ohmori T, Numata S, Yoshikawa T, Toyota T, Yamakawa K, Suzuki T, Inoue Y, Nakaoka K, Goto YI, Inagaki M, Hashimoto N, Kusumi I, Son S, Murai T, Ikegame T, Okada N, Kasai K, Kunimoto S, Mori D, Iwata N, Ozaki N

Cell reports Vol. 24 ( 11 ) page： 2838-2856 2018.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.celrep.2018.08.022

PubMed
The neuropathological investigation of the brain in a monkey model of autism spectrum disorder with ABCA13 deletion.

Iritani S, Torii Y, Habuchi C, Sekiguchi H, Fujishiro H, Yoshida M, Go Y, Iriki A, Isoda M, Ozaki N

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience Vol. 71 page： 130-139 2018.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.ijdevneu.2018.09.002

PubMed
Dysfunction of Serotonergic and Dopaminergic Neuronal Systems in the Antidepressant-Resistant Impairment of Social Behaviors Induced by Social Defeat Stress Exposure as Juveniles.

Hasegawa S, Miyake Y, Yoshimi A, Mouri A, Hida H, Yamada K, Ozaki N, Nabeshima T, Noda Y

The international journal of neuropsychopharmacology Vol. 21 ( 9 ) page： 837-846 2018.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/ijnp/pyy038

PubMed
Aberrant functional connectivity between the thalamus and visual cortex is related to attentional impairment in schizophrenia

Yamamoto Maeri, Kushima Itaru, Suzuki Ryohei, Branko Aleksic, Kawano Naoko, Inada Toshiya, Iidaka Tetsuya, Ozaki Norio

PSYCHIATRY RESEARCH-NEUROIMAGING Vol. 278 page： 35-41 2018.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pscychresns.2018.06.007

Web of Science

PubMed
Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia

Sobue Akira, Kushima Itaru, Nagai Taku, Shan Wei, Kohno Takao, Aleksic Branko, Aoyama Yuki, Mori Daisuke, Arioka Yuko, Kawano Naoko, Yamamoto Maeri, Hattori Mitsuharu, Nabeshima Toshitaka, Yamada Kiyofumi, Ozaki Norio

SCIENTIFIC REPORTS Vol. 8 ( 1 ) page： 13046 2018.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41598-018-31390-w

Web of Science

PubMed
Postpartum depression among women in Nagoya indirectly exposed to the Great East Japan Earthquake

Kubota Chika, Okada Takashi, Morikawa Mako, Nakamura Yukako, Yamauchi Aya, Ando Masahiko, Shiino Tomoko, Ohara Masako, Murase Satomi, Goto Setsuko, Kanai Atsuko, Masuda Tomoko, Aleksic Branko, Ozaki Norio

SCIENTIFIC REPORTS Vol. 8 ( 1 ) page： 11624 2018.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41598-018-30065-w

Web of Science

PubMed
Three lines of induced pluripotent stem cells derived from a 15q11.2-q13.1 duplication syndrome patient

Arioka Yuko, Kushima Itaru, Mori Daisuke, Ozaki Norio

STEM CELL RESEARCH Vol. 31 page： 240-243 2018.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.scr.2018.08.004

Web of Science

PubMed
The neuropathological study of myelin oligodendrocyte glycoprotein in the temporal lobe of schizophrenia patients

Marui Tomoyasu, Torii Youta, Iritani Shuji, Sekiguchi Hirotaka, Habuchi Chikako, Fujishiro Hiroshige, Oshima Kenichi, Niizato Kazuhiro, Hayashida Shotaro, Masaki Katsuhisa, Kira Junichi, Ozaki Norio

ACTA NEUROPSYCHIATRICA Vol. 30 ( 4 ) page： 232-240 2018.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1017/neu.2018.6

Web of Science

PubMed
Single-cell trajectory analysis of human homogenous neurons carrying a rare RELN variant

Arioka Yuko, Shishido Emiko, Kubo Hisako, Kushima Itaru, Yoshimi Akira, Kimura Hiroki, Ishizuka Kanako, Aleksic Branko, Maeda Takuji, Ishikawa Mitsuru, Kuzumaki Naoko, Okano Hideyuki, Mori Daisuke, Ozaki Norio

TRANSLATIONAL PSYCHIATRY Vol. 8 ( 1 ) page： 129 2018.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41398-018-0177-8

Web of Science

PubMed
Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability.

Kunisawa K, Shimizu T, Kushima I, Aleksic B, Mori D, Osanai Y, Kobayashi K, Taylor AM, Bhat MA, Hayashi A, Baba H, Ozaki N, Ikenaka K

Journal of neurochemistry 2018.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/jnc.14553

PubMed
Abnormalities of eye movement are associated with work hours in schizophrenia.

Morita K, Miura K, Fujimoto M, Shishido E, Shiino T, Takahashi J, Yamamori H, Yasuda Y, Kudo N, Hirano Y, Koshiyama D, Okada N, Ikeda M, Onitsuka T, Ozaki N, Kasai K, Hashimoto R

Schizophrenia research 2018.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2018.06.064

PubMed
Re-evaluating classical body type theories: genetic correlation between psychiatric disorders and body mass index

Ikeda Masashi, Tanaka Satoshi, Saito Takeo, Ozaki Norio, Kamatani Yoichiro, Iwata Nakao

PSYCHOLOGICAL MEDICINE Vol. 48 ( 10 ) page： 1745-1748 2018.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1017/S0033291718000685

Web of Science

PubMed
Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion

Arioka Yuko, Kushima Itaru, Kubo Hisako, Mori Daisuke, Ozaki Norio

STEM CELL RESEARCH Vol. 30 page： 81-84 2018.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.scr.2018.05.013

Web of Science

PubMed
Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial

Yamasue, H. Okada, T. Munesue, T. Kuroda, M. Fujioka, T. Uno, Y. Matsumoto, K. Kuwabara, H. Mori, D. Okamoto, Y. Yoshimura, Y. Kawakubo, Y. Arioka, Y. Kojima, M. Yuhi, T. Owada, K. Yassin, W. Kushima, I. Benner, S. Ogawa, N. Eriguchi, Y. Kawano, N. Uemura, Y. Yamamoto, M. Kano, Y. Kasai, K. Higashida, H. Ozaki, N. Kosaka, H.

Mol Psychiatry 2018.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： doi.org/10.1038/s41380-018-0097-2
Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial.

Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H

Molecular psychiatry 2018.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41380-018-0097-2

PubMed
Validation and Factor Analysis of the Japanese Version of the Highs Scale in Perinatal Women

Yamauchi Aya, Okada Takashi, Ando Masahiko, Morikawa Mako, Nakamura Yukako, Kubota Chika, Ohara Masako, Murase Satomi, Goto Setsuko, Kanai Atsuko, Ozaki Norio

FRONTIERS IN PSYCHIATRY Vol. 9 page： 269 2018.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3389/fpsyt.2018.00269

Web of Science

PubMed
Early diagnosis of Lewy body disease in patients with late-onset psychiatric disorders using clinical history of rapid eye movement sleep behavior disorder and [I-123]-metaiodobenzylguanidine cardiac scintigraphy

Fujishiro Hiroshige, Okuda Masato, Iwamoto Kunihiro, Miyata Seiko, Torii Youta, Iritani Shuji, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 72 ( 6 ) page： 423-434 2018.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12651

Web of Science

PubMed
Driving performance of stable outpatients with depression undergoing real-world treatment

Miyata Akemi, Iwamoto Kunihiro, Kawano Naoko, Aleksic Branko, Ando Masahiko, Ebe Kazutoshi, Fujita Kiyoshi, Yokoyama Motonori, Akiyama Tsuyoshi, Igarashi Yoshio, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 72 ( 6 ) page： 399-408 2018.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12648

Web of Science

PubMed
Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder

Reinbold Celine S., Forstner Andreas J., Hecker Julian, Fullerton Janice M., Hoffmann Per, Hou Liping, Heilbronner Urs, Degenhardt Franziska, Adli Mazda, Akiyama Kazufumi, Akula Nirmala, Ardau Raffaella, Arias Barbara, Backlund Lena, Benabarre Antonio, Bengesser Susanne, Bhattacharjee Abesh K., Biernacka Joanna M., Birner Armin, Marie-Claire Cynthia, Cervantes Pablo, Chen Guo-Bo, Chen Hsi-Chung, Chillotti Caterina, Clark Scott R., Colom Francesc, Cousins David A., Cruceanu Cristiana, Czerski Piotr M., Dayer Alexandre, Etain Bruno, Falkai Peter, Frisen Louise, Gard Sebastien, Garnham Julie S., Goes Fernando S., Grof Paul, Gruber Oliver, Hashimoto Ryota, Hauser Joanna, Herms Stefan, Jamain Stephane, Jimenez Esther, Kahn Jean-Pierre, Kassem Layla, Kittel-Schneider Sarah, Kliwicki Sebastian, Koenig Barbara, Kusumi Ichiro, Lackner Nina, Laje Gonzalo, Landen Mikael, Lavebratt Catharina, Leboyer Marion, Leckband Susan G., Lopez Jaramillo Carlos A., MacQueen Glenda, Manchia Mirko, Martinsson Lina, Mattheisen Manuel, McCarthy Michael J., McElroy Susan L., Mitjans Marina, Mondimore Francis M., Monteleone Palmiero, Nievergelt Caroline M., Osby Urban, Ozaki Norio, Perlis Roy H., Pfennig Andrea, Reich-Erkelenz Daniela, Rouleau Guy A., Schofield Peter R., Schubert K. Oliver, Schweizer Barbara W., Seemueller Florian, Severino Giovanni, Shekhtman Tatyana, Shilling Paul D., Shimoda Kazutaka, Simhandl Christian, Slaney Claire M., Smoller Jordan W., Squassina Alessio, Stamm Thomas J., Stopkova Pavla, Tighe Sarah K., Tortorella Alfonso, Turecki Gustavo, Volkert Julia, Witt Stephanie H., Wright Adam J., Young L. Trevor, Zandi Peter P., Potash James B., DePaulo J. Raymond, Bauer Michael, Reininghaus Eva, Novak Tomas, Aubry Jean-Michel, Maj Mario, Baune Bernhard T., Mitchell Philip B., Vieta Eduard, Frye Mark A., Rybakowski Janusz K., Kuo Po-Hsiu, Kato Tadafumi, Grigoroiu-Serbanescu Maria, Reif Andreas, Del Zompo Maria, Bellivier Frank, Schalling Martin, Wray Naomi R., Kelsoe John R., Alda Martin, McMahon Francis J., Schulze Thomas G., Rietschel Marcella, Nothen Markus M., Cichon Sven

FRONTIERS IN PSYCHIATRY Vol. 9 page： 207 2018.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3389/fpsyt.2018.00207

Web of Science

PubMed
Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis

Mouri Akihiro, Ukai Mayu, Uchida Mizuki, Hasegawa Sho, Taniguchi Masayuki, Ito Takahiro, Hida Hirotake, Yoshimi Akira, Yamada Kiyofumi, Kunimoto Shohko, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro

NEUROPHARMACOLOGY Vol. 133 page： 23-37 2018.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neuropharm.2018.01.016

Web of Science

PubMed
Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders

Ishizuka Kanako, Tabata Hidenori, Ito Hidenori, Kushima Itaru, Noda Mariko, Yoshimi Akira, Usami Masahide, Watanabe Kyota, Morikawa Mako, Uno Yota, Okada Takashi, Mori Daisuke, Aleksic Branko, Ozaki Norio, Nagata Koh-ichi

JOURNAL OF NEUROSCIENCE RESEARCH Vol. 96 ( 5 ) page： 789-802 2018.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/jnr.24194

Web of Science

PubMed
Copy Number Variant in the Region of Adenosine Kinase (ADK) and Its Possible Contribution to Schizophrenia Susceptibility

Kimura Hiroki, Kushima Itaru, Yohimi Akira, Aleksic Branko, Ozaki Norio

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY Vol. 21 ( 5 ) page： 405-409 2018.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/ijnp/pyx103

Web of Science

PubMed
An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan

Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Wakabayashi Toshihiko, Kuzuya Masafumi, Ozaki Norio, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Sobue Gen

NEUROIMAGE Vol. 169 page： 134-144 2018.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neuroimage.2017.12.014

Web of Science

PubMed
A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder

Ikeda M., Takahashi A., Kamatani Y., Okahisa Y., Kunugi H., Mori N., Sasaki T., Ohmori T., Okamoto Y., Kawasaki H., Shimodera S., Kato T., Yoneda H., Yoshimura R., Iyo M., Matsuda K., Akiyama M., Ashikawa K., Kashiwase K., Tokunaga K., Kondo K., Saito T., Shimasaki A., Kawase K., Kitajima T., Matsuo K., Itokawa M., Someya T., Inada T., Hashimoto R., Inoue T., Akiyama K., Tanii H., Arai H., Kanba S., Ozaki N., Kusumi I., Yoshikawa T., Kubo M., Iwata N.

MOLECULAR PSYCHIATRY Vol. 23 ( 3 ) page： 639-647 2018.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/mp.2016.259

Web of Science
Issues on the diagnosis and etiopathogenesis of mood disorders: reconsidering DSM-5

Ogasawara Kazuyoshi, Nakamura Yukako, Kimura Hiroyuki, Aleksic Branko, Ozaki Norio

JOURNAL OF NEURAL TRANSMISSION Vol. 125 ( 2 ) page： 211-222 2018.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00702-017-1828-2

Web of Science

PubMed
Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder

Takata Atsushi, Miyake Noriko, Tsurusaki Yoshinori, Fukai Ryoko, Miyatake Satoko, Koshimizu Eriko, Kushima Itaru, Okada Takashi, Morikawa Mako, Uno Yota, Ishizuka Kanako, Nakamura Kazuhiko, Tsujii Masatsugu, Yoshikawa Takeo, Toyota Tomoko, Okamoto Nobuhiko, Hiraki Yoko, Hashimoto Ryota, Yasuda Yuka, Saitoh Shinji, Ohashi Kei, Sakai Yasunari, Ohga Shouichi, Hara Toshiro, Kato Mitsuhiro, Nakamura Kazuyuki, Ito Aiko, Seiwa Chizuru, Shirahata Emi, Osaka Hitoshi, Matsumoto Ayumi, Takeshita Saoko, Tohyama Jun, Saikusa Tomoko, Matsuishi Toyojiro, Nakamura Takumi, Tsuboi Takashi, Kato Tadafumi, Suzuki Toshifumi, Saitsu Hirotomo, Nakashima Mitsuko, Mizuguchi Takeshi, Tanaka Fumiaki, Mori Norio, Ozaki Norio, Matsumoto Naomichi

CELL REPORTS Vol. 22 ( 3 ) page： 734-747 2018.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.celrep.2017.12.074

Web of Science

PubMed
Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility

Yu Yanjie, Lin Yingni, Takasaki Yuto, Wang Chenyao, Kimura Hiroki, Xing Jingrui, Ishizuka Kanako, Toyama Miho, Kushima Itaru, Mori Daisuke, Arioka Yuko, Uno Yota, Shiino Tomoko, Nakamura Yukako, Okada Takashi, Morikawa Mako, Ikeda Masashi, Iwata Nakao, Okahisa Yuko, Takaki Manabu, Sakamoto Shinji, Someya Toshiyuki, Egawa Jun, Usami Masahide, Kodaira Masaki, Yoshimi Akira, Oya-Ito Tomoko, Aleksic Branko, Ohno Kinji, Ozaki Norio

TRANSLATIONAL PSYCHIATRY Vol. 8 ( 1 ) page： 12 2018.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41398-017-0061-y

Web of Science

PubMed
Right treatment for the right schizophrenic patients based on carbonyl stress pathophysiology

Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 72 ( 1 ) page： 2-2 2018.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12620

Web of Science

PubMed
Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder A Genome-Wide Association Study

Amare Azmeraw T., Schubert Klaus Oliver, Hou Liping, Clark Scott R., Papiol Sergi, Heilbronner Urs, Degenhardt Franziska, Tekola-Ayele Fasil, Hsu Yi-Hsiang, Shekhtman Tatyana, Adli Mazda, Akula Nirmala, Akiyama Kazufumi, Ardau Raffaella, Arias Barbara, Aubry Jean-Michel, Backlund Lena, Bhattacharjee Abesh Kumar, Bellivier Frank, Benabarre Antonio, Bengesser Susanne, Biernacka Joanna M., Birner Armin, Brichant-Petitjean Clara, Cervantes Pablo, Chen Hsi-Chung, Chillotti Caterina, Cichon Sven, Cruceanu Cristiana, Czerski Piotr M., Dalkner Nina, Dayer Alexandre, Del Zompo Maria, DePaulo J. Raymond, Etain Bruno, Falkai Peter, Forstner Andreas J., Frisen Louise, Frye Mark A., Fullerton Janice M., Gard Sebastien, Garnham Julie S., Goes Fernando S., Grigoroiu-Serbanescu Maria, Grof Paul, Hashimoto Ryota, Hauser Joanna, Herms Stefan, Hoffmann Per, Hofmann Andrea, Jamain Stephane, Jimenez Esther, Kahn Jean-Pierre, Kassem Layla, Kuo Po-Hsiu, Kato Tadafumi, Kelsoe John, Kittel-Schneider Sarah, Kliwicki Sebastian, Koenig Barbara, Kusumi Ichiro, Laje Gonzalo, Landen Mikael, Lavebratt Catharina, Leboyer Marion, Leckband Susan G., Tortorella Alfonso, Manchia Mirko, Martinsson Lina, McCarthy Michael J., McElroy Susan, Colom Francesc, Mitjans Marina, Mondimore Francis M., Monteleone Palmiero, Nievergelt Caroline M., Noethen Markus M., Novak Tomas, O'Donovan Claire, Ozaki Norio, Osby Urban, Pfennig Andrea, Potash James B., Reif Andreas, Reininghaus Eva, Rouleau Guy A., Rybakowski Janusz K., Schalling Martin, Schofield Peter R., Schweizer BarbaraW., Severino Giovanni, Shilling Paul D., Shimoda Katzutaka, Simhandl Christian, Slaney Claire M., Squassina Alessio, Stamm Thomas, Stopkova Pavla, Maj Mario, Turecki Gustavo, Vieta Eduard, Volkert Julia, Witt Stephanie, Wright Adam, Zandi Peter P., Mitchell Philip B., Bauer Michael, Alda Martin, Rietschel Marcella, McMahon Francis J., Schulze Thomas G., Baune Bernhard T.

JAMA PSYCHIATRY Vol. 75 ( 1 ) page： 65-74 2018.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1001/jamapsychiatry.2017.3433

Web of Science

PubMed
Successful Post-Transplant Psychiatric Interventions During Long-Term Follow-Up of Patients Receiving Liver Transplants for Alcoholic Liver Disease.

Kimura H, Onishi Y, Kishi S, Kurata N, Ogiso S, Kamei H, Tsuboi C, Yamaguchi N, Shiga A, Kondo M, Yokoyama Y, Takasato F, Fujishiro H, Ishizuka K, Okada T, Ogura Y, Ozaki N

The American journal of case reports Vol. 18 page： 1215-1219 2017.11

　More details

Language：English Publishing type：Research paper (scientific journal)

PubMed
Human neutrophils show decreased survival upon long-term exposure to clozapine

Goto Aya, Yoshimi Akira, Nagai Tomoko, Ukigai Mako, Mouri Akihiro, Ozaki Norio, Noda Yukihiro

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 32 ( 6 ) 2017.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.2629

Web of Science

PubMed
Relationship between maternal depression and bonding failure: A prospective cohort study of pregnant women

Ohara Masako, Okada Takashi, Kubota Chika, Nakamura Yukako, Shiino Tomoko, Aleksic Branko, Morikawa Mako, Yamauchi Aya, Uno Yota, Murase Satomi, Goto Setsuko, Kanai Atsuko, Masuda Tomoko, Ando Masahiko, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 71 ( 10 ) page： 733-741 2017.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12541

Web of Science

PubMed
Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice

Matsumoto Yurie, Niwa Minae, Mouri Akihiro, Noda Yukihiro, Fukushima Takeshi, Ozaki Norio, Nabeshima Toshitaka

PSYCHOPHARMACOLOGY Vol. 234 ( 20 ) page： 3055-3074 2017.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00213-017-4704-8

Web of Science

PubMed
Regional decrease in gray matter volume is related to body dissatisfaction in anorexia nervosa

Kohmura Kunihiro, Adachi Yasunori, Tanaka Satoshi, Katayama Hiroto, Imaeda Miho, Kawano Naoko, Nishioka Kazuo, Ando Masahiko, Iidaka Tetsuya, Ozaki Norio

PSYCHIATRY RESEARCH-NEUROIMAGING Vol. 267 page： 51-58 2017.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pscychresns.2017.07.004

Web of Science

PubMed
Human neutrophils show decreased survival upon long-term exposure to clozapine

Goto, A. Yoshimi, A. Nagai, T. Ukigai, M. Mouri, A. Ozaki, N. Noda, Y.

Hum Psychopharmacol 2017.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： doi.org/10.1002/hup.2629
Verbal Memory impairment in Patients with subsyndromal Bipolar Disorder

Sumiyoshi Tomiki, Toyomaki Atsuhito, Kawano Naoko, Kitajima Tomoko, Kusumi Ichiro, Ozaki Norio, Iwata Nakao, Sueyoshi Kazuki, Nakagome Kazuyuki

FRONTIERS IN PSYCHIATRY Vol. 8 page： 168 2017.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3389/fpsyt.2017.00168

Web of Science

PubMed
Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder

Lim Elaine T., Uddin Mohammed, De Rubeis Silvia, Chan Yingleong, Kamumbu Anne S., Zhang Xiaochang, D'Gama Alissa M., Kim Sonia N., Hill Robert Sean, Goldberg Arthur P., Poultney Christopher, Minshew Nancy J., Kushima Itaru, Aleksic Branko, Ozaki Norio, Parellada Mara, Arango Celso, Penzol Maria J., Carracedo Angel, Kolevzon Alexander, Hultman Christina M., Weiss Lauren A., Fromer Menachem, Chiocchetti Andreas G., Freitag Christine M., Church George M., Scherer Stephen W., Buxbaum Joseph D., Walsh Christopher A.

NATURE NEUROSCIENCE Vol. 20 ( 9 ) page： 1217-+ 2017.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/nn.4598

Web of Science

PubMed
Social support helps protect against perinatal bonding failure and depression among mothers: a prospective cohort study

Ohara Masako, Okada Takashi, Aleksic Branko, Morikawa Mako, Kubota Chika, Nakamura Yukako, Shiino Tomoko, Yamauchi Aya, Uno Yota, Murase Satomi, Goto Setsuko, Kanai Atsuko, Masuda Tomoko, Nakatochi Masahiro, Ando Masahiko, Ozaki Norio

SCIENTIFIC REPORTS Vol. 7 ( 1 ) page： 9546 2017.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41598-017-08768-3

Web of Science

PubMed
A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility

Kimura H., Fujita Y., Kawabata T., Ishizuka K., Wang C., Iwayama Y., Okahisa Y., Kushima I., Morikawa M., Uno Y., Okada T., Ikeda M., Inada T., Branko A., Mori D., Yoshikawa T., Iwata N., Nakamura H., Yamashita T., Ozaki N.

TRANSLATIONAL PSYCHIATRY Vol. 7 2017.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/tp.2017.170

Web of Science
Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders

Ishizuka K., Fujita Y., Kawabata T., Kimura H., Iwayama Y., Inada T., Okahisa Y., Egawa J., Usami M., Kushima I., Uno Y., Okada T., Ikeda M., Aleksic B., Mori D., Someya To, Yoshikawa T., Iwata N., Nakamura H., Yamashita T., Ozaki N.

TRANSLATIONAL PSYCHIATRY Vol. 7 2017.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/tp.2017.173

Web of Science
Verbal memory impairments in bipolar disorder: Effect of type of word learning tasks

Sumiyoshi Tomiki, Toyomaki Atsuhito, Kawano Naoko, Kitajima Tomoko, Kusumi Ichiro, Ozaki Norio, Iwata Nakao, Sueyoshi Kazuki, Nakagome Kazuyuki

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 71 ( 8 ) page： 570-U77 2017.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12536

Web of Science

PubMed
Enrichment of deleterious variants of mitochondrial DNA polymerase gene (POLG1) in bipolar disorder

Kasahara Takaoki, Ishiwata Mizuho, Kakiuchi Chihiro, Fuke Satoshi, Iwata Nakao, Ozaki Norio, Kunugi Hiroshi, Minabe Yoshio, Nakamura Kazuhiko, Iwata Yasuhide, Fujii Kumiko, Kanba Shigenobu, Ujike Hiroshi, Kusumi Ichiro, Kataoka Muneko, Matoba Nana, Takata Atsushi, Iwamoto Kazuya, Yoshikawa Takeo, Kato Tadafumi

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 71 ( 8 ) page： 518-529 2017.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12496

Web of Science

PubMed
Transethnic Replication Study to Assess the Association Between Clozapine-Induced Agranulocytosis/Granulocytopenia and Genes at 12p12.2 in a Japanese Population.

Saito T, Ikeda M, Hashimoto R, Iwata N, Members of the Clozapine Pharmacogenomics Consortium of Japan are the following., Yamamori H, Yasuda Y, Fujimoto M, Kondo K, Shimasaki A, Kawase K, Miyata M, Mushiroda T, Ozeki T, Kubo M, Fujita K, Kida N, Nakai M, Otsuru T, Fukuji Y, Murakami M, Mizuno K, Shiratsuchi T, Numata S, Ohmori T, Ueno SI, Yada Y, Tanaka S, Kishi Y, Takaki M, Mamoto A, Taniguchi N, Sawa Y, Watanabe H, Noda T, Amano Y, Kimura T, Fukao T, Suwa T, Murai T, Kubota M, Ueda K, Tabuse H, Kanahara N, Kawai N, Nemoto K, Makinodan M, Nishihata Y, Hashimoto N, Kusumi I, Fujii Y, Miyata R, Hirakawa K, Ozaki N

Biological psychiatry Vol. 82 ( 1 ) page： e9-e10 2017.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.biopsych.2016.12.009

PubMed
Reliability and validity of the California Verbal Learning Test-II - Japanese version

Sumiyoshi Tomiki, Toyomaki Atsuhito, Kawano Naoko, Kitajima Tomoko, Kusumi Ichiro, Ozaki Norio, Iwata Nakao, Nakagome Kazuyuki

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 71 ( 6 ) page： 417-418 2017.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12525

Web of Science

PubMed
Reliability and validity of the California verbal learning test (CVLT) -II - Japanese version in patients with subsyndromal bipolar disorder

Sumiyoshi T., Toyomaki A., Kawano N., Kitajima T., Kusumi I., Ozaki N., Iwata N., Nakagome K.

BIPOLAR DISORDERS Vol. 19 page： 111-111 2017.5

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Estimated cognitive decline in patients with schizophrenia: A multicenter study

Fujino Haruo, Sumiyoshi Chika, Yasuda Yuka, Yamamori Hidenaga, Fujimoto Michiko, Fukunaga Masaki, Miura Kenichiro, Takebayashi Yuto, Okada Naohiro, Isomura Shuichi, Kawano Naoko, Toyomaki Atsuhito, Kuga Hironori, Isobe Masanori, Oya Kazuto, Okahisa Yuko, Takaki Manabu, Hashimoto Naoki, Kato Masaki, Onitsuka Toshiaki, Ueno Takefumi, Ohnuma Tohru, Kasai Kiyoto, Ozaki Norio, Sumiyoshi Tomiki, Imura Osamu, Hashimoto Ryota

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 71 ( 5 ) page： 294-300 2017.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12474

Web of Science

PubMed
REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series

Fujishiro Hiroshige, Okuda Masato, Iwamoto Kunihiro, Miyata Seiko, Otake Hironao, Noda Akiko, Iritani Shuji, Ozaki Norio

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY Vol. 32 ( 4 ) page： 397-406 2017.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/gps.4477

Web of Science

PubMed
Neuropeptide Y neuronal network dysfunction in the frontal lobe of a genetic mouse model of schizophrenia

Morosawa Shunsuke, Iritani Shuji, Fujishiro Hiroshige, Sekiguchi Hirotaka, Torii Youta, Habuchi Chikako, Kuroda Keisuke, Kaibuchi Kozo, Ozaki Norio

NEUROPEPTIDES Vol. 62 page： 27-35 2017.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.npep.2016.12.010

Web of Science

PubMed
Similarity of symptoms between transient epileptic amnesia and Lewy body disease

Ukai Katsuyuki, Fujishiro Hiroshige, Watanabe Masako, Kosaka Kenji, Ozaki Norio

PSYCHOGERIATRICS Vol. 17 ( 2 ) page： 120-125 2017.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/psyg.12199

Web of Science

PubMed
Effect of Adjunctive Aripiprazole on Sexual Dysfunction in Schizophrenia: A Preliminary Open-Label Study

Fujioi Junko, Iwamoto Kunihiro, Banno Masahiro, Kikuchi Tsutomu, Aleksic Branko, Ozaki Norio

PHARMACOPSYCHIATRY Vol. 50 ( 2 ) page： 74-78 2017.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1055/s-0042-116323

Web of Science
High-resolution copy number variation analysis of schizophrenia in Japan

Kushima I., Aleksic B., Nakatochi M., Shimamura T., Shiino T., Yoshimi A., Kimura H., Takasaki Y., Wang C., Xing J., Ishizuka K., Oya-Ito T., Nakamura Y., Arioka Y., Maeda T., Yamamoto M., Yoshida M., Noma H., Hamada S., Morikawa M., Uno Y., Okada T., Iidaka T., Iritani S., Yamamoto T., Miyashita M., Kobori A., Arai M., Itokawa M., Cheng M-C, Chuang Y-A, Chen C-H, Suzuki M., Takahashi T., Hashimoto R., Yamamori H., Yasuda Y., Watanabe Y., Nunokawa A., Someya T., Ikeda M., Toyota T., Yoshikawa T., Numata S., Ohmori T., Kunimoto S., Mori D., Iwata N., Ozaki N.

MOLECULAR PSYCHIATRY Vol. 22 ( 3 ) page： 430-440 2017.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/mp.2016.88

Web of Science
Effectiveness of low-dose pregabalin in three patients with Lewy body disease and central neuropathic pain

Ukai Katsuyuki, Fujishiro Hiroshige, Ozaki Norio

PSYCHOGERIATRICS Vol. 17 ( 2 ) page： 115-119 2017.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/psyg.12192

Web of Science

PubMed
Risk of alcohol use relapse after liver transplantation for alcoholic liver disease

Onishi Yasuharu, Kimura Hiroyuki, Hori Tomohide, Kishi Shinichi, Kamei Hideya, Kurata Nobuhiko, Tsuboi Chisato, Yamaguchi Naoko, Takahashi Mayu, Sunada Saki, Hirano Mitsuaki, Fujishiro Hiroshige, Okada Takashi, Ishigami Masatoshi, Goto Hidemi, Ozaki Norio, Ogura Yasuhiro

WORLD JOURNAL OF GASTROENTEROLOGY Vol. 23 ( 5 ) page： 869-875 2017.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3748/wjg.v23.i5.869

Web of Science

PubMed
Rapid eye movement sleep without atonia may help diagnose Lewy body disease in middle-aged and older patients with somatic symptom disorder

Munechika Takayuki, Fujishiro Hiroshige, Okuda Masato, Iwamoto Kunihiro, Torii Youta, Iritani Shuji, Ozaki Norio

PSYCHOGERIATRICS Vol. 17 ( 1 ) page： 61-69 2017.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/psyg.12181

Web of Science

PubMed
Effect of aripiprazole augmentation for depressive symptoms changes with progression of Lewy body disease

Iwamoto Kunihiro, Fujishiro Hiroshige, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 71 ( 1 ) page： 74-75 2017.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12479

Web of Science

PubMed
Influence of sleep duration on cortical oxygenation in elderly individuals

Kato Kazuko, Miyata Seiko, Ando Motoo, Matsuoka Hiroki, Yasuma Fumihiko, Iwamoto Kunihiro, Kawano Naoko, Banno Masahiro, Ozaki Norio, Noda Akiko

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 71 ( 1 ) page： 44-51 2017.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12464

Web of Science

PubMed
Schizophrenia polygenic risk score and prepubertal developmental impairments

Aleksic Branko, Ozaki Norio

LANCET PSYCHIATRY Vol. 4 ( 1 ) page： 7-8 2017.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/S2215-0366(16)30409-6

Web of Science

PubMed
Current Viewpoints on DSM-5 in Japan

Kuroki T, Ishitobi M, Kamio Y, Sugihara G, Murai T, Motomura K, Ogasawara K, Kimura H, Aleksic B, Ozaki N, Nakao T, Yamada K, Yoshiuchi K, Kiriike N, Ishikawa T, Kubo C, Matsunaga C, Miyata H, Asada T, Kanba S

Psychiatry Clin Neurosci Vol. 70 ( 9 ) page： 371-393 2016.9

　More details

Language：English

DOI： 10.1111/pcn.12421
Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population Reviewed

Kimura Hiroki, Tanaka Satoshi, Kushima Itaru, Koide Takayoshi, Banno Masahiro, Kikuchi Tsutomu, Nakamura Yukako, Shiino Tomoko, Yoshimi Akira, Oya-Ito Tomoko, Xing Jingrui, Wang Chenyao, Takasaki Yuto, Aleksic Branko, Okada Takashi, Ikeda Masashi, Inada Toshiya, Iidaka Tetsuya, Iwata Nakao, Ozaki Norio

SCIENTIFIC REPORTS Vol. 5 2015.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/srep15705

Web of Science
White matter microstructure between the pre-SMA and the cingulum bundle is related to response conflict in healthy subjects Reviewed

Yamamoto Maeri, Kushima Itaru, Kimura Hiroki, Hayashi Akiko, Kawano Naoko, Aleksic Branko, Iidaka Tetsuya, Ozaki Norio

BRAIN AND BEHAVIOR Vol. 5 ( 10 ) 2015.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/brb3.375

Web of Science
Autopsy-confirmed hippocampal-sparing Alzheimer's disease with delusional jealousy as initial manifestation Reviewed

Fujishiro Hiroshige, Iritani Shuji, Hattori Miho, Sekiguchi Hirotaka, Matsunaga Shinji, Habuchi Chikako, Torii Youta, Umeda Kentaro, Ozaki Norio, Yoshida Mari, Fujita Kiyoshi

PSYCHOGERIATRICS Vol. 15 ( 3 ) page： 198-203 2015.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/psyg.12105

Web of Science
Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies Reviewed

Nishizawa Daisuke, Kasai Shinya, Hasegawa Junko, Sato Naomi, Yamada Hidetaka, Tanioka Fumihiko, Nagashima Makoto, Katoh Ryoji, Satoh Yasuo, Tagami Megumi, Ujike Hiroshi, Ozaki Norio, Inada Toshiya, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Yamada Mitsuhiko, Kondo Naoki, Won Moo-Jun, Naruse Nobuya, Uehara-Aoyama Kumi, Itokawa Masanari, Ohi Kazutaka, Hashimoto Ryota, Tanisawa Kumpei, Arai Tomio, Mori Seijiro, Sawabe Motoji, Naka-Mieno Makiko, Yamada Yoshiji, Yamada Miki, Sato Noriko, Muramatsu Masaaki, Tanaka Masashi, Irukayama-Tomobe Yoko, Saito Yuki C., Sakurai Takeshi, Hayashida Masakazu, Sugimura Haruhiko, Ikeda Kazutaka

MOLECULAR BRAIN Vol. 8 2015.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s13041-015-0142-x

Web of Science
Glia-related genes and their contribution to schizophrenia Reviewed

Wang Chenyao, Aleksic Branko, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 69 ( 8 ) page： 448-461 2015.8

　More details

Language：English

DOI： 10.1111/pcn.12290

Web of Science
The effects of acute treatment with ramelteon, triazolam, and placebo on driving performance, cognitive function, and equilibrium function in healthy volunteers Reviewed

Miyata Akemi, Iwamoto Kunihiro, Kawano Naoko, Kohmura Kunihiro, Yamamoto Maeri, Aleksic Branko, Ebe Kazutoshi, Noda Akiko, Noda Yukihiro, Iritani Shuji, Ozaki Norio

PSYCHOPHARMACOLOGY Vol. 232 ( 12 ) page： 2127-2137 2015.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00213-014-3843-4

Web of Science
Long-term efficacy of donepezil for relapse of visual hallucinations in patients with dementia with Lewy bodies Reviewed

Ukai Katsuyuki, Fujishiro Hiroshige, Iritani Shuji, Ozaki Norio

PSYCHOGERIATRICS Vol. 15 ( 2 ) page： 133-137 2015.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/psyg.12089

Web of Science
No support for replication of the genetic variants identified by a recent mega-analysis of the treatment response to antidepressants Reviewed

Hatano Masakazu, Ikeda Masashi, Kondo Kenji, Saito Takeo, Shimasaki Ayu, Esaki Kosei, Umene-Nakano Wakako, Yoshimura Reiji, Nakamura Jun, Ozaki Norio, Iwata Nakao

JOURNAL OF HUMAN GENETICS Vol. 60 ( 6 ) page： 343-344 2015.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/jhg.2015.21

Web of Science
Relationship between social support during pregnancy and postpartum depressive state: a prospective cohort study Reviewed

Morikawa Mako, Okada Takashi, Ando Masahiko, Aleksic Branko, Kunimoto Shohko, Nakamura Yukako, Kubota Chika, Uno Yota, Tamaji Ai, Hayakawa Norika, Furumura Kaori, Shiino Tomoko, Morita Tokiko, Ishikawa Naoko, Ohoka Harue, Usui Hinako, Banno Naomi, Murase Satomi, Goto Setsuko, Kanai Atsuko, Masuda Tomoko, Ozaki Norio

SCIENTIFIC REPORTS Vol. 5 2015.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/srep10520

Web of Science
Early exposure to the combined measles-mumps-rubella vaccine and thimerosal-containing vaccines and risk of autism spectrum disorder Reviewed

Uno Yota, Uchiyama Tokio, Kurosawa Michiko, Aleksic Branko, Ozaki Norio

VACCINE Vol. 33 ( 21 ) page： 2511-2516 2015.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.vaccine.2014.12.036

Web of Science
Temperament and character profiles of patients with burning mouth syndrome Reviewed

Tokura Tatsuya, Kimura Hiroyuki, Ito Mikiko, Nagashima Wataru, Sato Naohiro, Kimura Yuki, Arao Munetaka, Aleksic Branko, Yoshida Keizo, Kurita Kenichi, Ozaki Norio

JOURNAL OF PSYCHOSOMATIC RESEARCH Vol. 78 ( 5 ) page： 495-498 2015.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jpsychores.2015.02.006

Web of Science
Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility Reviewed

Kimura Hiroki, Tsuboi Daisuke, Wang Chenyao, Kushima Itaru, Koide Takayoshi, Ikeda Masashi, Iwayama Yoshimi, Toyota Tomoko, Yamamoto Noriko, Kunimoto Shohko, Nakamura Yukako, Yoshimi Akira, Banno Masahiro, Xing Jingrui, Takasaki Yuto, Yoshida Mami, Aleksic Branko, Uno Yota, Okada Takashi, Iidaka Tetsuya, Inada Toshiya, Suzuki Michio, Ujike Hiroshi, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Iwata Nakao, Kaibuchi Kozo, Ozaki Norio

SCHIZOPHRENIA BULLETIN Vol. 41 ( 3 ) page： 744-753 2015.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/schbul/sbu147

Web of Science
Novel Rare Missense Variations and Risk of Autism Spectrum Disorder: Whole-Exome Sequencing in Two Families with Affected Siblings and a Two-Stage Follow-Up Study in a Japanese Population Reviewed

Egawa Jun, Watanabe Yuichiro, Wang Chenyao, Inoue Emiko, Sugimoto Atsunori, Sugiyama Toshiro, Igeta Hirofumi, Nunokawa Ayako, Shibuya Masako, Kushima Itaru, Orime Naoki, Hayashi Taketsugu, Okada Takashi, Uno Yota, Ozaki Norio, Someya Toshiyuki

PLOS ONE Vol. 10 ( 3 ) 2015.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0119413

Web of Science
What is the nature of the autism 'spectrum'? Reviewed

Okada Takashi, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 69 ( 3 ) page： 129-130 2015.3

　More details

Language：English

DOI： 10.1111/pcn.12276

Web of Science
Genetic Overlap Between Antipsychotic Response and Susceptibility to Schizophrenia Reviewed

Ikeda Masashi, Yoshimura Reiji, Hashimoto Ryota, Kondo Kenji, Saito Takeo, Shimasaki Ayu, Ohi Kazutaka, Tochigi Mamoru, Kawamura Yoshiya, Nishida Nao, Miyagawa Taku, Sasaki Tsukasa, Tokunaga Katsushi, Kasai Kiyoto, Takeda Masatoshi, Nakamura Jun, Ozaki Norio, Iwata Nakao

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY Vol. 35 ( 1 ) page： 85-88 2015.2

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Blonanserin Ameliorates Phencyclidine-Induced Visual-Recognition Memory Deficits: the Complex Mechanism of Blonanserin Action Involving D-3-5-HT2A and D-I-NMDA Receptors in the mPFC Reviewed

Hida Hirotake, Mouri Akihiro, Mori Kentaro, Matsumoto Yurie, Seki Takeshi, Taniguchi Masayuki, Yamada Kiyofumi, Iwamoto Kunihiro, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro

NEUROPSYCHOPHARMACOLOGY Vol. 40 ( 3 ) page： 601-613 2015.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/npp.2014.207

Web of Science
The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects Reviewed

Takahashi Tsutomu, Nakamura Mihoko, Nakamura Yukako, Aleksic Branko, Kido Mikio, Sasabayashi Daiki, Takayanagi Yoichiro, Furuichi Atsushi, Nishikawa Yumiko, Noguchi Kyo, Ozaki Norio, Suzuki Michio

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Vol. 56 page： 11-17 2015.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pnpbp.2014.07.005

Web of Science
Efficacy of aripiprazole augmentation in Japanese patients with major depressive disorder: A subgroup analysis and Montgomery-Asberg Depression Rating Scale and Hamilton Rating Scale for Depression item analyses of the Aripiprazole Depression Multicenter Efficacy study Reviewed

Ozaki Norio, Otsubo Tempei, Kato Masaki, Higuchi Teruhiko, Ono Hiroaki, Kamijima Kunitoshi

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 69 ( 1 ) page： 34-42 2015.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12214

Web of Science
Five Patients With Burning Mouth Syndrome in Whom an Antidepressant (Serotonin-Noradrenaline Reuptake Inhibitor) Was Not Effective, but Pregabalin Markedly Relieved Pain Reviewed

Ito Mikiko, Tokura Tatsuya, Yoshida Keizo, Nagashima Wataru, Kimura Hiroyuki, Umemura Eri, Tachibana Masako, Miyauchi Tomoya, Kobayashi Yuka, Arao Munetaka, Ozaki Norio, Kurita Kenichi

CLINICAL NEUROPHARMACOLOGY Vol. 38 ( 4 ) page： 158-161 2015

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/WNF.0000000000000093

Web of Science
Synaptic, transcriptional and chromatin genes disrupted in autism Reviewed

De Rubeis Silvia, He Xin, Goldberg Arthur P., Poultney Christopher S., Samocha Kaitlin, Cicek A. Ercument, Kou Yan, Liu Li, Fromer Menachem, Walker Susan, Singh Tarjinder, Klei Lambertus, Kosmicki Jack, Fu Shih-Chen, Aleksic Branko, Biscaldi Monica, Bolton Patrick F., Brownfeld Jessica M., Cai Jinlu, Campbell Nicholas G., Carracedo Angel, Chahrour Maria H., Chiocchetti Andreas G., Coon Hilary, Crawford Emily L., Crooks Lucy, Curran Sarah R., Dawson Geraldine, Duketis Eftichia, Fernandez Bridget A., Gallagher Louise, Geller Evan, Guter Stephen J., Hill R. Sean, Ionita-Laza Iuliana, Gonzalez Patricia Jimenez, Kilpinen Helena, Klauck Sabine M., Kolevzon Alexander, Lee Irene, Lei Jing, Lehtimaeki Terho, Lin Chiao-Feng, Ma'ayan Avi, Marshall Christian R., McInnes Alison L., Neale Benjamin, Owen Michael J., Ozaki Norio, Parellada Mara, Parr Jeremy R., Purcell Shaun, Puura Kaija, Rajagopalan Deepthi, Rehnstrom Karola, Reichenberg Abraham, Sabo Aniko, Sachse Michael, Sanders Stephan J., Schafer Chad, Schulte-Ruether Martin, Skuse David, Stevens Christine, Szatmari Peter, Tammimies Kristiina, Valladares Otto, Voran Annette, Wang Li-San, Weiss Lauren A., Willsey A. Jeremy, Yu Timothy W., Yuen Ryan K. C., Cook Edwin H., Freitag Christine M., Gill Michael, Hultman Christina M., Lehner Thomas, Palotie Aarno, Schellenberg Gerard D., Skiar Pamela, State Matthew W., Sutcliffe James S., Walsh Christopher A., Scherer Stephen W., Zwick Michael E., Barrett Jeffrey C., Cutler David J., Roeder Kathryn, Devlin Bernie, Daly Mark J., Buxbaum Joseph D.

NATURE Vol. 515 ( 7526 ) page： 209-U119 2014.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/nature13772

Web of Science
Resequencing and Association Analysis of PTPRA, a Possible Susceptibility Gene for Schizophrenia and Autism Spectrum Disorders Reviewed

Xing Jingrui, Wang Chenyao, Kimura Hiroki, Takasaki Yuto, Kunimoto Shohko, Yoshimi Akira, Nakamura Yukako, Koide Takayoshi, Banno Masahiro, Kushima Itaru, Uno Yota, Okada Takashi, Aleksic Branko, Ikeda Masashi, Iwata Nakao, Ozaki Norio

PLOS ONE Vol. 9 ( 11 ) 2014.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0112531

Web of Science
Common variants at 1p36 are associated with superior frontal gyrus volume Reviewed

Hashimoto R., Ikeda M., Yamashita F., Ohi K., Yamamori H., Yasuda Y., Fujimoto M., Fukunaga M., Nemoto K., Takahashi T., Tochigi M., Onitsuka T., Yamasue H., Matsuo K., Iidaka T., Iwata N., Suzuki M., Takeda M., Kasai K., Ozaki N.

TRANSLATIONAL PSYCHIATRY Vol. 4 2014.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/tp.2014.110

Web of Science
The Polymorphism of YWHAE, a Gene Encoding 14-3-3Epsilon, and Brain Morphology in Schizophrenia: A Voxel-Based Morphometric Study Reviewed

Kido Mikio, Nakamura Yukako, Nemoto Kiyotaka, Takahashi Tsutomu, Aleksic Branko, Furuichi Atsushi, Nakamura Yumiko, Ikeda Masashi, Noguchi Kyo, Kaibuchi Kozo, Iwata Nakao, Ozaki Norio, Suzuki Michio

PLOS ONE Vol. 9 ( 8 ) 2014.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0103571

Web of Science
Factor Structure of the Japanese Version of the Edinburgh Postnatal Depression Scale in the Postpartum Period Reviewed

Kubota Chika, Okada Takashi, Aleksic Branko, Nakamura Yukako, Kunimoto Shohko, Morikawa Mako, Shiino Tomoko, Tamaji Ai, Ohoka Harue, Banno Naomi, Morita Tokiko, Murase Satomi, Goto Setsuko, Kanai Atsuko, Masuda Tomoko, Ando Masahiko, Ozaki Norio

PLOS ONE Vol. 9 ( 8 ) 2014.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0103941

Web of Science
Novel rare variants in F-box protein 45 (FBXO45) in schizophrenia Reviewed

Wang Chenyao, Koide Takayoshi, Kimura Hiroki, Kunimoto Shohko, Yoshimi Akira, Nakamura Yukako, Kushima Itaru, Banno Masahiro, Kawano Naoko, Takasaki Yuto, Xing Jingrui, Noda Yukihiro, Mouri Akihiro, Aleksic Branko, Ikeda Masashi, Okada Takashi, Iidaka Tetsuya, Inada Toshiya, Iwata Nakao, Ozaki Norio

SCHIZOPHRENIA RESEARCH Vol. 157 ( 1-3 ) page： 149-156 2014.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2014.04.032

Web of Science
Effects of maternal depressive symptomatology during pregnancy and the postpartum period on infant-mother attachment Reviewed

Ohoka Harue, Koide Takayoshi, Goto Setsuko, Murase Satomi, Kanai Atsuko, Masuda Tomoko, Aleksic Branko, Ishikawa Naoko, Furumura Kaori, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 68 ( 8 ) page： 631-639 2014.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12171

Web of Science
Replication and Cross-Phenotype Study Based Upon Schizophrenia GWASs Data in the japanese Population: Support for Association of MHC Region with Psychosis Reviewed

Saito Takeo, Kondo Kenji, Iwayama Yoshimi, Shimasaki Ayu, Aleksic Branko, Yamada Kazuo, Toyota Tomoko, Hattori Eiji, Esaki Kosei, Ujike Hiroshi, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ozaki Norio, Ikeda Masashi, Iwata Nakao

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 165 ( 5 ) page： 421-427 2014.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.32246

Web of Science
Reliability and Validity of the New Tanaka B Intelligence Scale Scores: A Group Intelligence Test Reviewed

Uno Yota, Mizukami Hitomi, Ando Masahiko, Yukihiro Ryoji, Iwasaki Yoko, Ozaki Norio

PLOS ONE Vol. 9 ( 6 ) 2014.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0100262

Web of Science
Social insecurity in relation to orbitofrontal activity in patients with eating disorders: a near-infrared spectroscopy study Reviewed

Katayama Hiroto, Kohmura Kunihiro, Tanaka Satoshi, Imaeda Miho, Kawano Naoko, Noda Yukihiro, Nishioka Kazuo, Ando Masahiko, Aleksic Branko, Iidaka Tetsuya, Ozaki Norio

BMC PSYCHIATRY Vol. 14 2014.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/1471-244X-14-173

Web of Science
The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects Reviewed

Takahashi Tsutomu, Nakamura Yumiko, Nakamura Yukako, Aleksic Branko, Takayanagi Yoichiro, Furuichi Atsushi, Kido Mikio, Nakamura Mihoko, Sasabayashi Daiki, Ikeda Masashi, Noguchi Kyo, Kaibuchi Kozo, Iwata Nakao, Ozaki Norio, Suzuki Michio

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Vol. 51 page： 166-171 2014.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pnpbp.2014.02.005

Web of Science
Plasma dehydroepiandrosterone sulfate levels in patients with major depressive disorder correlate with remission during treatment with antidepressants Reviewed

Morita Tokiko, Senzaki Koji, Ishihara Ryoko, Umeda Kazunori, Iwata Nakao, Nagai Taku, Hida Hirotake, Nabeshima Toshitaka, Yukawa Kazunori, Ozaki Norio, Noda Yukihiro

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 29 ( 3 ) page： 280-286 2014.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.2400

Web of Science
Preoperative Level of Depression is a Predictor of Postoperative Levels of Depression in Patients with Head and Neck Cancer Reviewed

Adachi Yasunori, Kimura Hiroyuki, Sato Naohiro, Nagashima Wataru, Nakamura Kouki, Aleksic Branko, Yoshida Keizo, Fujimoto Yasushi, Nakashima Tsutomu, Ozaki Norio

JAPANESE JOURNAL OF CLINICAL ONCOLOGY Vol. 44 ( 4 ) page： 311-317 2014.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/jjco/hyu002

Web of Science
Copy-number variation in the pathogenesis of autism spectrum disorder Reviewed

Shishido Emiko, Aleksic Branko, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 68 ( 2 ) page： 85-95 2014.2

　More details

Language：English

DOI： 10.1111/pcn.12128

Web of Science
Combination of neonatal PolyI:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice Reviewed

Hida Hirotake, Mouri Akihiro, Ando Yu, Mori Kentaro, Mamiya Takayoshi, Iwamoto Kunihiro, Ozaki Norio, Yamada Kiyofumi, Nabeshima Toshitaka, Noda Yukihiro

BEHAVIOURAL BRAIN RESEARCH Vol. 258 page： 34-42 2014.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.bbr.2013.09.026

Web of Science
The effects of acute treatment with paroxetine, amitriptyline, and placebo on the equilibrium function in healthy subjects: A double-blind crossover trial Reviewed

Miyata Seiko, Noda Akiko, Iwamoto Kunihiro, Takahashi Masahiro, Hara Yuki, Kojima Jun, Iidaka Tetsuya, Ozaki Norio

INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE Vol. 18 ( 1 ) page： 32-36 2014.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3109/13651501.2013.813551

Web of Science
Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population Reviewed

Kajio Yusuke, Kondo Kenji, Saito Takeo, Iwayama Yoshimi, Aleksic Branko, Yamada Kazuo, Toyota Tomoko, Hattori Eiji, Ujike Hiroshi, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ozaki Norio, Ikeda Masashi, Iwata Nakao

JOURNAL OF HUMAN GENETICS Vol. 59 ( 1 ) page： 54-56 2014.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/jhg.2013.116

Web of Science
Genome-wide association study identifies a potent locus associated with human opioid sensitivity Reviewed

Nishizawa D., Fukuda K., Kasai S., Hasegawa J., Aoki Y., Nishi A., Saita N., Koukita Y., Nagashima M., Katoh R., Satoh Y., Tagami M., Higuchi S., Ujike H., Ozaki N., Inada T., Iwata N., Sora I., Iyo M., Kondo N., Won M-J, Naruse N., Uehara-Aoyama K., Itokawa M., Koga M., Arinami T., Kaneko Y., Hayashida M., Ikeda K.

MOLECULAR PSYCHIATRY Vol. 19 ( 1 ) page： 55-62 2014.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/mp.2012.164

Web of Science
Replication of enhanced carbonyl stress in a subpopulation of schizophrenia Reviewed

Miyashita Mitsuhiro, Arai Makoto, Yuzawa Hiroko, Niizato Kazuhiro, Oshima Kenichi, Kushima Itaru, Hashimoto Ryota, Fukumoto Motoyuki, Koike Shinsuke, Toyota Tomoko, Ujike Hiroshi, Arinami Tadao, Kasai Kiyoto, Takeda Masatoshi, Ozaki Norio, Okazaki Yuji, Yoshikawa Takeo, Amano Naoji, Miyata Toshio, Itokawa Masanari

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 68 ( 1 ) page： 83-84 2014.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12087

Web of Science
The possibility of prostaglandin E-2 (PGE(2)) as a common molecule associated with vulnerability to neurodevelopmental disruptions Reviewed

Hida Hirotake, Mouri Akihiro, Mori Kentaro, Furuyashiki Tomoyuki, Yamada Kiyofumi, Ozaki Norio, Narumiya Shuh, Nabeshima Toshitaka, Noda Yukihiro

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 124 page： 75P-75P 2014

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
The intronic SNP of PCLO is associated with dependence-like behavior in genomic association syudy, and regulates DA and 5-HT uptake in the cultured cells Reviewed

Uno Kyosuke, Nishizawa Daisuke, Seo Seunghee, Takayama Kanako, Matsumura Shohei, Sakai Norio, Ohi Kazutaka, Nabeshima Toshitaka, Ryota Hashimoto, Ozaki Norio, Ikeda Kazutaka, Miyamoto Yoshiaki, Nitta Atsumi

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 124 page： 183P-183P 2014

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
The role of glial glutamate transporter (GLAST) in psychobehavioral abnormalities following repeated administration of phencyclidine Reviewed

Mori Kentaro, Matsumoto Yurie, Hida Hirotake, Mouri Akihiro, Yamada Kiyofumi, Ozaki Norio, Tanaka Kohichi, Nabeshima Toshitaka, Noda Yukihiro

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 124 page： 215P-215P 2014

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
The role of glial glutamate transporter (GLAST) in cognitive functions in mice Reviewed

Noda Yukihiro, Hasegawa Shoh, Taniguchi Masayuki, Hida Hirotake, Mouri Akihiro, Kunimoto Masako, Yamada Kiyofumi, Ozaki Norio, Tanaka Kohichi, Nabeshima Toshitaka

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 124 page： 212P-212P 2014

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Aripiprazole augmentation to antidepressant therapy in Japanese patients with major depressive disorder: A randomized, double-blind, placebo-controlled study (ADMIRE study) Reviewed

Kamijima Kunitoshi, Higuchi Teruhiko, Ishigooka Jun, Ohmori Tetsuro, Ozaki Norio, Kanba Shigenobu, Kinoshita Toshihiko, Koyama Tsukasa

JOURNAL OF AFFECTIVE DISORDERS Vol. 151 ( 3 ) page： 899-905 2013.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jad.2013.07.035

Web of Science
Replication in a Japanese population that a MIR30E gene variation is associated with schizophrenia Reviewed

Watanabe Yuichiro, Iijima Yoshimi, Egawa Jun, Nunokawa Ayako, Kaneko Naoshi, Arinami Tadao, Ujike Hiroshi, Inada Toshiya, Iwata Nakao, Kunugi Hiroshi, Itokawa Masanari, Sasaki Tsukasa, Ozaki Norio, Hashimoto Ryota, Shibuya Masako, Igeta Hirofumi, Someya Toshiyuki

SCHIZOPHRENIA RESEARCH Vol. 150 ( 2-3 ) page： 596-597 2013.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2013.08.028

Web of Science
Functional Analysis of Deep Intronic SNP rs13438494 in Intron 24 of PCLO Gene Reviewed

Seo Seunghee, Takayama Kanako, Uno Kyosuke, Ohi Kazutaka, Hashimoto Ryota, Nishizawa Daisuke, Ikeda Kazutaka, Ozaki Norio, Nabeshima Toshitaka, Miyamoto Yoshiaki, Nitta Atsumi

PLOS ONE Vol. 8 ( 10 ) 2013.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0076960

Web of Science
Poor sleep quality impairs cognitive performance in older adults Reviewed

Miyata Seiko, Noda Akiko, Iwamoto Kunihiro, Kawano Naoko, Okuda Masato, Ozaki Norio

JOURNAL OF SLEEP RESEARCH Vol. 22 ( 5 ) page： 535-541 2013.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/jsr.12054

Web of Science
COMMON VARIANTS IN BCL9 GENE AND SCHIZOPHRENIA IN A JAPANESE POPULATION: ASSOCIATION STUDY, META-ANALYSIS AND COGNITIVE FUNCTION ANALYSIS Reviewed

Shiino Tomoko, Koide Takayoshi, Kushima Itaru, Ikeda Masashi, Kunimoto Shohko, Nakamura Yukako, Yoshimi Akira, Aleksic Branko, Banno Masahiro, Kikuchi Tsutomu, Kohmura Kunihiro, Adachi Yasunori, Kawano Naoko, Okada Takashi, Inada Toshiya, Ujike Hiroshi, Iidaka Tetsuya, Suzuki Michio, Iwata Nakao, Ozaki Norio

JOURNAL OF MEDICAL BIOCHEMISTRY Vol. 32 ( 4 ) page： 361-367 2013.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.2478/jomb-2013-0049

Web of Science
Lack of association of EGR2 variants with bipolar disorder in Japanese population Reviewed

Balan Shabeesh, Yamada Kazuo, Iwayama Yoshimi, Toyota Tomoko, Ohnishi Tetsuo, Maekawa Motoko, Toyoshima Manabu, Iwata Yasuhide, Suzuki Katsuald, Kikuchi Mitsuru, Ujike Hiroshi, Inada Toshiya, Kunugi Hiroshi, Ozaki Norio, Iwata Nakao, Nanko Shinichiro, Kato Tadafumi, Yoshikawa Takeo

GENE Vol. 526 ( 2 ) page： 246-250 2013.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.gene.2013.05.055

Web of Science
Definition and refinement of the 7q36.3 duplication region associated with schizophrenia Reviewed

Aleksic Branko, Kushima Itaru, Ohye Tamae, Ikeda Masashi, Kunimoto Shohko, Nakamura Yukako, Yoshimi Akira, Koide Takayoshi, Iritani Shuji, Kurahashi Hiroki, Iwata Nakao, Ozaki Norio

SCIENTIFIC REPORTS Vol. 3 2013.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/srep02587

Web of Science
Evidence for Shared Genetic Risk Between Methamphetamine-Induced Psychosis and Schizophrenia Reviewed

Ikeda Masashi, Okahisa Yuko, Aleksic Branko, Won Mujun, Kondo Naoki, Naruse Nobuya, Aoyama-Uehara Kumi, Sora Ichiro, Iyo Masaomi, Hashimoto Ryota, Kawamura Yoshiya, Nishida Nao, Miyagawa Taku, Takeda Masatoshi, Sasaki Tsukasa, Tokunaga Katsushi, Ozaki Norio, Ujike Hiroshi, Iwata Nakao

NEUROPSYCHOPHARMACOLOGY Vol. 38 ( 10 ) page： 1864-1870 2013.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/npp.2013.94

Web of Science
Effects of low-dose mirtazapine on driving performance in healthy volunteers Reviewed

Iwamoto Kunihiro, Kawano Naoko, Sasada Kazumi, Kohmura Kunihiro, Yamamoto Maeri, Ebe Kazutoshi, Noda Yukihiro, Ozaki Norio

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 28 ( 5 ) page： 523-528 2013.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.2327

Web of Science
Genetic Variants on 3q21 and in the Sp8 Transcription Factor Gene (SP8) as Susceptibility Loci for Psychotic Disorders: A Genetic Association Study Reviewed

Kondo Kenji, Ikeda Masashi, Kajio Yusuke, Saito Takeo, Iwayama Yoshimi, Aleksic Branko, Yamada Kazuo, Toyota Tomoko, Hattori Eiji, Ujike Hiroshi, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ozaki Norio, Iwata Nakao

PLOS ONE Vol. 8 ( 8 ) 2013.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0070964

Web of Science
An association analysis of the cardiomyopathy-associated 5 (CMYA5) gene with schizophrenia in a Japanese population Reviewed

Furukawa Masaomi, Tochigi Mamoru, Otowa Takeshi, Arinami Tadao, Inada Toshiya, Ujike Hiroshi, Watanabe Yuichiro, Iwata Nakao, Itokawa Masanari, Kunugi Hiroshi, Hashimoto Ryota, Ozaki Norio, Kakiuchi Chihiro, Kasai Kiyoto, Sasaki Tsukasa

PSYCHIATRIC GENETICS Vol. 23 ( 4 ) page： 179-180 2013.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/YPG.0b013e328360c8be

Web of Science
Further evidence of an association between a genetic variant in BMP7 and treatment response to SSRIs in major depressive disorder Reviewed

Esaki Kosei, Kondo Kenji, Hatano Masakazu, Saito Takeo, Kishi Taro, Umene-Nakano Wakako, Yoshimura Reiji, Nakamura Jun, Ozaki Norio, Ikeda Masashi, Iwata Nakao

JOURNAL OF HUMAN GENETICS Vol. 58 ( 8 ) page： 568-569 2013.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/jhg.2013.52

Web of Science
Necessity of normative data on the Japanese version of the Wechsler Memory Scale-Revised Logical Memory subtest for old-old people Reviewed

Kawano Naoko, Awata Shuichi, Ijuin Mutsuo, Iwamoto Kunihiro, Ozaki Norio

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 13 ( 3 ) page： 726-730 2013.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/ggi.12007

Web of Science
Maternal overprotection score of the Parental Bonding Instrument predicts the outcome of cognitive behavior therapy by trainees for depression Reviewed

Asano Motoshi, Esaki Kosei, Wakamatsu Aya, Kitajima Tomoko, Narita Tomohiro, Naitoh Hiroshi, Ozaki Norio, Iwata Nakao

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 67 ( 5 ) page： 340-344 2013.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pcn.12054

Web of Science
Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report Reviewed

Manchia Mirko, Adli Mazda, Akula Nirmala, Ardau Raffaella, Aubry Jean-Michel, Backlund Lena, Banzato Claudio E. M., Baune Bernhard T., Bellivier Frank, Bengesser Susanne, Biernacka Joanna M., Brichant-Petitjean Clara, Bui Elise, Calkin Cynthia V., Cheng Andrew Tai Ann, Chillotti Caterina, Cichon Sven, Clark Scott, Czerski Piotr M., Dantas Clarissa, Del Zompo Maria, DePaulo J. Raymond, Detera-Wadleigh Sevilla D., Etain Bruno, Falkai Peter, Frisen Louise, Frye Mark A., Fullerton Jan, Gard Sebastien, Garnham Julie, Goes Fernando S., Grof Paul, Gruber Oliver, Hashimoto Ryota, Hauser Joanna, Heilbronner Urs, Hoban Rebecca, Hou Liping, Jamain Stephane, Kahn Jean-Pierre, Kassem Layla, Kato Tadafumi, Kelsoe John R., Kittel-Schneider Sarah, Kliwicki Sebastian, Kuo Po-Hsiu, Kusumi Ichiro, Laje Gonzalo, Lavebratt Catharina, Leboyer Marion, Leckband Susan G., Lopez Jaramillo Carlos A., Maj Mario, Malafosse Alain, Martinsson Lina, Masui Takuya, Mitchell Philip B., Mondimore Frank, Monteleone Palmiero, Nallet Audrey, Neuner Maria, Novak Tomas, O'Donovan Claire, Osby Urban, Ozaki Norio, Perlis Roy H., Pfennig Andrea, Potash James B., Reich-Erkelenz Daniela, Reif Andreas, Reininghaus Eva, Richardson Sara, Rouleau Guy A., Rybakowski Janusz K., Schalling Martin, Schofield Peter R., Schubert Oliver K., Schweizer Barbara, Seemueller Florian, Grigoroiu-Serbanescu Maria, Severino Giovanni, Seymour Lisa R., Slaney Claire, Smoller Jordan W., Squassina Alessio, Stamm Thomas, Steele Jo, Stopkova Pavla, Tighe Sarah K., Tortorella Alfonso, Turecki Gustavo, Wray Naomi R., Wright Adam, Zandi Peter P., Zilles David, Bauer Michael, Rietschel Marcella, McMahon Francis J., Schulze Thomas G., Alda Martin

PLOS ONE Vol. 8 ( 6 ) 2013.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0065636

Web of Science
Genome-Wide Association Study of Cognitive Decline in Schizophrenia Reviewed

Hashimoto Ryota, Ikeda Masashi, Ohi Kazutaka, Yasuda Yuka, Yamamori Hidenaga, Fukumoto Motoyuki, Umeda-Yano Satomi, Dickinson Dwight, Aleksic Branko, Iwase Masao, Kazui Hiroaki, Ozaki Norio, Weinberger Daniel R., Iwata Nakao, Takeda Masatoshi

AMERICAN JOURNAL OF PSYCHIATRY Vol. 170 ( 6 ) page： 683-684 2013.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1176/appi.ajp.2013.12091228

Web of Science
Effectiveness of low-dose milnacipran for a patient suffering from pain disorder with delusional disorder (somatic type) in the orofacial region Reviewed

Ukai Katsuyuki, Kimura Hiroyuki, Arao Munetaka, Aleksic Branko, Yamauchi Aya, Ishihara Ryoko, Iritani Shuji, Kurita Kenichi, Ozaki Norio

PSYCHOGERIATRICS Vol. 13 ( 2 ) page： 99-102 2013.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1479-8301.2012.00430.x

Web of Science
Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population Reviewed

Ikeda M., Aleksic B., Yamada K., Iwayama-Shigeno Y., Matsuo K., Numata S., Watanabe Y., Ohnuma T., Kaneko T., Fukuo Y., Okochi T., Toyota T., Hattori E., Shimodera S., Itakura M., Nunokawa A., Shibata N., Tanaka H., Yoneda H., Arai H., Someya T., Ohmori T., Yoshikawa T., Ozaki N., Iwata N.

MOLECULAR PSYCHIATRY Vol. 18 ( 6 ) page： 636-638 2013.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/mp.2012.74

Web of Science
Genome-wide association study of schizophrenia using microsatellite markers in the Japanese population Reviewed

Shibata Hiroki, Yamamoto Ken, Sun Zhu, Oka Akira, Inoko Hidetoshi, Arinami Tadao, Inada Toshiya, Ujike Hiroshi, Itokawa Masanari, Tochigi Mamoru, Watanabe Yuichiro, Someya Toshiyuki, Kunugi Hiroshi, Suzuki Tatsuyo, Iwata Nakao, Ozaki Norio, Fukumaki Yasuyuki

PSYCHIATRIC GENETICS Vol. 23 ( 3 ) page： 117-123 2013.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/YPG.0b013e32835fe4f1

Web of Science
Analysis of the VAV3 as Candidate Gene for Schizophrenia: Evidences From Voxel-Based Morphometry and Mutation Screening Reviewed

Aleksic Branko, Kushima Itaru, Hashimoto Ryota, Ohi Kazutaka, Ikeda Masashi, Yoshimi Akira, Nakamura Yukako, Ito Yoshihito, Okochi Tomo, Fukuo Yasuhisa, Yasuda Yuka, Fukumoto Motoyuki, Yamamori Hidenaga, Ujike Hiroshi, Suzuki Michio, Inada Toshiya, Takeda Masatoshi, Kaibuchi Kozo, Iwata Nakao, Ozaki Norio

SCHIZOPHRENIA BULLETIN Vol. 39 ( 3 ) page： 720-728 2013.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/schbul/sbs038

Web of Science
Effects of repeated dosing with mirtazapine, trazodone, or placebo on driving performance and cognitive function in healthy volunteers Reviewed

Sasada Kazumi, Iwamoto Kunihiro, Kawano Naoko, Kohmura Kunihiro, Yamamoto Maeri, Aleksic Branko, Ebe Kazutoshi, Noda Yukihiro, Ozaki Norio

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 28 ( 3 ) page： 281-286 2013.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.2321

Web of Science
Total palliative care for a patient with multiple cerebral infarctions that occurred repeatedly in association with gastric cancer (Trousseau's syndrome) Reviewed

Ukai Katsuyuki, Okajima Akiko, Yamauchi Aya, Sasaki Eiji, Yamaguchi Yohsuke, Kimura Hiroyuki, Aleksic Branko, Ozaki Norio

PALLIATIVE & SUPPORTIVE CARE Vol. 11 ( 2 ) page： 169-172 2013.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1017/S1478951512000624

Web of Science
A Population-Specific Uncommon Variant in GRIN3A Associated with Schizophrenia Reviewed

Takata Atsushi, Iwayama Yoshimi, Fukuo Yasuhisa, Ikeda Masashi, Okochi Tomo, Maekawa Motoko, Toyota Tomoko, Yamada Kazuo, Hattori Eiji, Ohnishi Tetsuo, Toyoshima Manabu, Ujike Hiroshi, Inada Toshiya, Kunugi Hiroshi, Ozaki Norio, Nanko Shinichiro, Nakamura Kazuhiko, Mori Norio, Kanba Shigenobu, Iwata Nakao, Kato Tadafumi, Yoshikawa Takeo

BIOLOGICAL PSYCHIATRY Vol. 73 ( 6 ) page： 532-539 2013.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.biopsych.2012.10.024

Web of Science
Effects of sedative antidepressants on prefrontal cortex activity during verbal fluency task in healthy subjects: a near-infrared spectroscopy study Reviewed

Kohmura Kunihiro, Iwamoto Kunihiro, Aleksic Branko, Sasada Kazumi, Kawano Naoko, Katayama Hiroto, Noda Yukihiro, Noda Akiko, Iidaka Tetsuya, Ozaki Norio

PSYCHOPHARMACOLOGY Vol. 226 ( 1 ) page： 75-81 2013.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00213-012-2885-8

Web of Science
DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia Reviewed

Tanaka S., Syu A., Ishiguro H., Inada T., Horiuchi Y., Ishikawa M., Koga M., Noguchi E., Ozaki N., Someya T., Kakita A., Takahashi H., Nawa H., Arinami T.

PHARMACOGENOMICS JOURNAL Vol. 13 ( 1 ) page： 27-34 2013.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/tpj.2011.36

Web of Science
Adolescent Stress-Induced Epigenetic Control of Dopaminergic Neurons via Glucocorticoids Reviewed

Niwa Minae, Jaaro-Peled Hanna, Tankou Stephanie, Seshadri Saurav, Hikida Takatoshi, Matsumoto Yurie, Cascella Nicola G., Kano Shin-ichi, Ozaki Norio, Nabeshima Toshitaka, Sawa Akira

SCIENCE Vol. 339 ( 6117 ) page： 335-339 2013.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1126/science.1226931

Web of Science
Involvement of prostaglandin E2 in behavioral abnormalities induced by neonatal immune activation Reviewed

Hida Hirotake, Mouri Akihiro, Furuyashiki Tomoyuki, Yamada Kiyofumi, Ozaki Norio, Narumiya Shuh, Nabeshima Toshitaka, Noda Yukihiro

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 121 page： 123P-123P 2013

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Effects of Minocycline on Changes in Brain Tryptophan Metabolism and the Behavior of Juvenile Mice Elicited By Inescapable-Predator Stress.

Miura H, Ando Y, Noda Y, Ozak N, Isobe K

J Trauma Stress Disor Treat Vol. 2 ( 3 ) 2013

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： doi: 10.4172/2324-8947.1000107.
The Postpartum Depressive State in Relation to Perceived Rearing: A Prospective Cohort Study Reviewed

Hayakawa Norika, Koide Takayoshi, Okada Takashi, Murase Satomi, Aleksic Branko, Furumura Kaori, Shiino Tomoko, Nakamura Yukako, Tamaji Ai, Ishikawa Naoko, Ohoka Harue, Usui Hinako, Banno Naomi, Morita Tokiko, Goto Setsuko, Kanai Atsuko, Masuda Tomoko, Ozaki Norio

PLOS ONE Vol. 7 ( 11 ) 2012.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0050220

Web of Science
Association of Insomnia and Short Sleep Duration With Atherosclerosis Risk in the Elderly Reviewed

Nakazaki Chie, Noda Akiko, Koike Yasuo, Yamada Sumio, Murohara Toyoaki, Ozaki Norio

AMERICAN JOURNAL OF HYPERTENSION Vol. 25 ( 11 ) page： 1149-1155 2012.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/ajh.2012.107

Web of Science
An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders Reviewed

Matsunaga Shinji, Ikeda Masashi, Kishi Taro, Fukuo Yasuhisa, Aleksic Branko, Yoshimura Reiji, Okochi Tomo, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Umene-Nakano Wakako, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ujike Hiroshi, Nakamura Jun, Ozaki Norio, Kitajima Tsuyoshi, Iwata Nakao

NEUROSCIENCE LETTERS Vol. 529 ( 1 ) page： 66-69 2012.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2012.08.070

Web of Science
Myelin-related abnormality of schizophrenia: Genetic, imaging and postmortem study Reviewed

Ozaki Norio

ASIA-PACIFIC PSYCHIATRY Vol. 4 page： 34-34 2012.10

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Involvement of Shati on depression-like behavior in the postpartum period in human and mice Reviewed

Takaoka K., Uno K., Inagaki R., Nagakura M., Tamaji A., Ozaki N., Miyamoto Y., Nitta A.

JOURNAL OF NEUROCHEMISTRY Vol. 123 page： 73-73 2012.10

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
What is a rational antidepressant treatment for major depression in patients with Parkinson's disease? Reviewed

Hagikura Minako, Iwamoto Kunihiro, Aleksic Branko, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 66 ( 5 ) page： 463-463 2012.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1440-1819.2012.02362.x

Web of Science
Effects of Mild Cognitive Impairment on Driving Performance in Older Drivers Reviewed

Kawano Naoko, Iwamoto Kunihiro, Iidaka Tetsuya, Ozaki Norio, Suzuki Yusuke, Hasegawa Jun, Umegaki Hiroyuki, Ebe Kazutoshi, Ukai Katsuyuki

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY Vol. 60 ( 7 ) page： 1379-1381 2012.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1532-5415.2012.04021.x

Web of Science
The combined measles, mumps, and rubella vaccines and the total number of vaccines are not associated with development of autism spectrum disorder: The first case-control study in Asia Reviewed

Uno Yota, Uchiyama Tokio, Kurosawa Michiko, Aleksic Branko, Ozaki Norio

VACCINE Vol. 30 ( 28 ) page： 4292-4298 2012.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.vaccine.2012.01.093

Web of Science
Slower adaptation to driving simulator and simulator sickness in older adults Reviewed

Kawano Naoko, Iwamoto Kunihiro, Ebe Kazutoshi, Aleksic Branko, Noda Akiko, Umegaki Hiroyuki, Kuzuya Masafumi, Iidaka Tetsuya, Ozaki Norio

AGING CLINICAL AND EXPERIMENTAL RESEARCH Vol. 24 ( 3 ) page： 285-289 2012.6

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene-based case-control study and gene expression analysis Reviewed

Ohi Kazutaka, Hashimoto Ryota, Yasuda Yuka, Fukumoto Motoyuki, Yamamori Hidenaga, Umeda-Yano Satomi, Okada Takeya, Kamino Kouzin, Morihara Takashi, Iwase Masao, Kazui Hiroaki, Numata Shusuke, Ikeda Masashi, Ohnuma Tohru, Iwata Nakao, Ueno Shu-ichi, Ozaki Norio, Ohmori Tetsuro, Arai Heii, Takeda Masatoshi

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 159B ( 4 ) page： 405-413 2012.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.32043

Web of Science
No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia Reviewed

Kitazawa Maiko, Ohnuma Tohru, Takebayashi Yuto, Shibata Nobuto, Baba Hajime, Ohi Kazutaka, Yasuda Yuka, Nakamura Yukako, Aleksic Branko, Yoshimi Akira, Okochi Tomo, Ikeda Masashi, Naitoh Hiroshi, Hashimoto Ryota, Iwata Nakao, Ozaki Norio, Takeda Masatoshi, Arai Heii

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 159B ( 4 ) page： 456-464 2012.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.32049

Web of Science
Common Variants in MAGI2 Gene Are Associated with Increased Risk for Cognitive Impairment in Schizophrenic Patients Reviewed

Koide Takayoshi, Banno Masahiro, Aleksic Branko, Yamashita Saori, Kikuchi Tsutomu, Kohmura Kunihiro, Adachi Yasunori, Kawano Naoko, Kushima Itaru, Nakamura Yukako, Okada Takashi, Ikeda Masashi, Ohi Kazutaka, Yasuda Yuka, Hashimoto Ryota, Inada Toshiya, Ujike Hiroshi, Iidaka Tetsuya, Suzuki Michio, Takeda Masatoshi, Iwata Nakao, Ozaki Norio

PLOS ONE Vol. 7 ( 5 ) 2012.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0036836

Web of Science
A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population Reviewed

Watanabe Yuichiro, Egawa Jun, Iijima Yoshimi, Nunokawa Ayako, Kaneko Naoshi, Shibuya Masako, Arinami Tadao, Ujike Hiroshi, Inada Toshiya, Iwata Nakao, Tochigi Mamoru, Kunugi Hiroshi, Itokawa Masanari, Ozaki Norio, Hashimoto Ryota, Someya Toshiyuki

SCHIZOPHRENIA RESEARCH Vol. 137 ( 1-3 ) page： 264-266 2012.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2012.01.034

Web of Science
Differential effects of diazepam, tandospirone, and paroxetine on plasma brain-derived neurotrophic factor level under mental stress Reviewed

Tamaji Ai, Iwamoto Kunihiro, Kawamura Yukiko, Takahashi Masahiro, Ebe Kazutoshi, Kawano Naoko, Kunimoto Shohko, Aleksic Branko, Noda Yukihiro, Ozaki Norio

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 27 ( 3 ) page： 329-333 2012.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.2220

Web of Science
GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder Reviewed

Kishi, Taro; Ichinose, Hiroshi; Yoshimura, Reiji; Fukuo, Yasuhisa; Kitajima, Tsuyoshi; Inada, Toshiya; Kunugi, Hiroshi; Kato, Tadafumi; Yoshikawa, Takeo; Ujike, Hiroshi; Musso, Giovanna M.; Umene-Nakano, Wakako; Nakamura, Jun; Ozaki, Norio; Iwata, Nakao

JOURNAL OF AFFECTIVE DISORDERS Vol. 142 ( 1-3 ) page： 315-322 2012.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jad.2012.05.004

Web of Science
Plasma levels of milnacipran and its effectiveness for the treatment of chronic pain in the orofacial region Reviewed

Kimura Hiroyuki, Yoshida Keizo, Ito Mikiko, Tokura Tatsuya, Nagashima Wataru, Kurita Kenichi, Ozaki Norio

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 27 ( 3 ) page： 322-328 2012.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.2230

Web of Science
Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility Reviewed

Kushima Itaru, Nakamura Yukako, Aleksic Branko, Ikeda Masashi, Ito Yoshihito, Shiino Tomoko, Okochi Tomo, Fukuo Yasuhisa, Ujike Hiroshi, Suzuki Michio, Inada Toshiya, Hashimoto Ryota, Takeda Masatoshi, Kaibuchi Kozo, Iwata Nakao, Ozaki Norio

SCHIZOPHRENIA BULLETIN Vol. 38 ( 3 ) page： 552-560 2012.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/schbul/sbq118

Web of Science
Sexual dysfunction and hyperprolactinemia in Japanese schizophrenic patients taking antipsychotics Reviewed

Kikuchi Tsutomu, Iwamoto Kunihiro, Sasada Kazumi, Aleksic Branko, Yoshida Keizo, Ozaki Norio

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Vol. 37 ( 1 ) page： 26-32 2012.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pnpbp.2011.11.016

Web of Science
Prospective Study on the Association between Harm Avoidance and Postpartum Depressive State in a Maternal Cohort of Japanese Women Reviewed

Furumura Kaori, Koide Takayoshi, Okada Takashi, Murase Satomi, Aleksic Branko, Hayakawa Norika, Shiino Tomoko, Nakamura Yukako, Tamaji Ai, Ishikawa Naoko, Ohoka Harue, Usui Hinako, Banno Naomi, Morita Tokiko, Goto Setsuko, Kanai Atsuko, Masuda Tomoko, Ozaki Norio

PLOS ONE Vol. 7 ( 4 ) 2012.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0034725

Web of Science
Effects of aging on the morphologies of Heschl's gyrus and the superior temporal gyrus in schizophrenia: A postmortem study Reviewed

Torii Youta, Iritani Shuji, Sekiguchi Hirotaka, Habuchi Chikako, Hagikura Minako, Arai Tetsuaki, Ikeda Kenji, Akiyama Haruhiko, Ozaki Norio

SCHIZOPHRENIA RESEARCH Vol. 134 ( 2-3 ) page： 137-142 2012.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2011.10.024

Web of Science
Serotonin 6 receptor gene and schizophrenia: case-control study and meta-analysis Reviewed

Kishi Taro, Fukuo Yasuhisa, Okochi Tomo, Kawashima Kunihiro, Kitajima Tsuyoshi, Inada Toshiya, Ozaki Norio, Musso Giovanna M., Kane John M., Correll Christoph U., Iwata Nakao

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 27 ( 1 ) page： 63-69 2012.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.1266

Web of Science
Association of SNPs linked to increased expression of SLC1A1 with schizophrenia Reviewed

Horiuchi Yasue, Iida Syuhei, Koga Minori, Ishiguro Hiroki, Iijima Yoshimi, Inada Toshiya, Watanabe Yuichiro, Someya Toshiyuki, Ujike Hiroshi, Iwata Nakao, Ozaki Norio, Kunugi Hiroshi, Tochigi Mamoru, Itokawa Masanari, Arai Makoto, Niizato Kazuhiro, Iritani Shuji, Kakita Akiyoshi, Takahashi Hitoshi, Nawa Hiroyuki, Arinami Tadao

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 159B ( 1 ) page： 30-37 2012.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.31249

Web of Science
Wisconsin Card Sorting Test scores and clinical and sociodemographic correlates in Schizophrenia: multiple logistic regression analysis Reviewed

Banno Masahiro, Koide Takayoshi, Aleksic Branko, Okada Takashi, Kikuchi Tsutomu, Kohmura Kunihiro, Adachi Yasunori, Kawano Naoko, Iidaka Tetsuya, Ozaki Norio

BMJ OPEN Vol. 2 ( 6 ) 2012

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1136/bmjopen-2012-001340

Web of Science
Blonanserin improves phencyclidine-induced impairment of recognition memory through dopamine D1 receptor Reviewed

Hida Hirotake, Ogino Yurie, Matsumoto Yurie, Mouri Akihiro, Seki Takeshi, Yamada Kiyofumi, Ozaki Norio, Nabeshima Toshitaka, Noda Yukihiro

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 118 page： 190P-190P 2012

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
CHRONIC SLEEP RESTRICTION IMPAIRED BRAIN TISSUE OXYGENATION IN FRONTAL LOBE Reviewed

Miyata S., Noda A., Iwamoto K., Ozaki N.

SLEEP Vol. 35 page： A107-A107 2012

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Evaluation of factors affecting continuous performance test identical pairs version score of schizophrenic patients in a Japanese clinical sample

Koide T, Aleksic B, Kikuchi T, Banno M, Kohmura K, Adachi Y, Kawano N, Iidaka T, Ozaki N

Schizophr Res Treatment Vol. 2012 page： 2012 970131 2012

　More details

Language：English Publishing type：Research paper (scientific journal)
Effectiveness of Duloxetine for the Treatment of Chronic Nonorganic Orofacial Pain Reviewed

Nagashima Wataru, Kimura Hiroyuki, Ito Mikiko, Tokura Tatsuya, Arao Munetaka, Aleksic Branko, Yoshida Keizo, Kurita Kenichi, Ozaki Norio

CLINICAL NEUROPHARMACOLOGY Vol. 35 ( 6 ) page： 273-277 2012

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/WNF.0b013e31827453fa

Web of Science
Combination use of Beck Depression Inventory and two-question case-finding instrument as a screening tool for depression in the workplace Reviewed

Adachi Yasunori, Aleksic Branko, Nobata Ryoko, Suzuki Tatsuyo, Yoshida Keizo, Ono Yuichiro, Ozaki Norio

BMJ OPEN Vol. 2 ( 3 ) 2012

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1136/bmjopen-2011-000596

Web of Science
CHRONIC SLEEP RESTRICTION INHIBITS BRAIN ACTIVITY MEASURED BY NEAR-INFRARED SPECTROSCOPY Reviewed

Miyata S., Noda A., Iwamoto K., Ozaki N.

EUROPEAN PSYCHIATRY Vol. 27 page： . 2012

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
A Case Control Association Study and Cognitive Function Analysis of Neuropilin and Tolloid-Like 1 Gene and Schizophrenia in the Japanese Population Reviewed

Banno Masahiro, Koide Takayoshi, Aleksic Branko, Yamada Kazuo, Kikuchi Tsutomu, Kohmura Kunihiro, Adachi Yasunori, Kawano Naoko, Kushima Itaru, Ikeda Masashi, Inada Toshiya, Yoshikawa Takeo, Iwata Nakao, Ozaki Norio

PLOS ONE Vol. 6 ( 12 ) 2011.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0028929

Web of Science
Positive Association of Phencyclidine-Responsive Genes, PDE4A and PLAT, With Schizophrenia Reviewed

Deng Xiangdong, Takaki Hiromi, Wang Lixiang, Kuroki Tosihide, Nakahara Tatsuo, Hashimoto Kijiro, Ninomiya Hideaki, Arinami Tadao, Inada Toshiya, Ujike Hiroshi, Itokawa Masanari, Tochigi Mamoru, Watanabe Yuichiro, Someya Toshiyuki, Kunugi Hiroshi, Iwata Nakao, Ozaki Norio, Shibata Hiroki, Fukumaki Yasuyuki

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 156B ( 7 ) page： 850-858 2011.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.31233

Web of Science
Loss of Function Studies in Mice and Genetic Association Link Receptor Protein Tyrosine Phosphatase alpha to Schizophrenia Reviewed

Takahashi Nagahide, Nielsen Karin Sandager, Aleksic Branko, Petersen Steffen, Ikeda Masashi, Kushima Itaru, Vacaresse Nathalie, Ujike Hiroshi, Iwata Nakao, Dubreuil Veronique, Mirza Naheed, Sakurai Takeshi, Ozaki Norio, Buxbaum Joseph D., Sap Jan

BIOLOGICAL PSYCHIATRY Vol. 70 ( 7 ) page： 626-635 2011.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.biopsych.2011.06.016

Web of Science
Prospective study of maternal depressive symptomatology among Japanese women Reviewed

Ishikawa Naoko, Goto Setsuko, Murase Satomi, Kanai Atsuko, Masuda Tomoko, Aleksic Branko, Usui Hinako, Ozaki Norio

JOURNAL OF PSYCHOSOMATIC RESEARCH Vol. 71 ( 4 ) page： 264-269 2011.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jpsychores.2011.02.001

Web of Science
Maternal mental disorders and pregnancy outcomes: A clinical study in a Japanese population Reviewed

Hironaka Masae, Kotani Tomomi, Sumigama Seiji, Tsuda Hiroyuki, Mano Yukio, Hayakawa Hiromi, Tanaka Satoshi, Ozaki Norio, Tamakoshi Koji, Kikkawa Fumitaka

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Vol. 37 ( 10 ) page： 1283-1289 2011.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1447-0756.2010.01512.x

Web of Science
No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population Reviewed

Kishi Taro, Fukuo Yasuhisa, Okochi Tomo, Kitajima Tsuyoshi, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Correll Christoph U., Iwata Nakao

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 26 ( 7 ) page： 445-450 2011.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.1223

Web of Science
Presenile dementia diagnosed as posterior cortical atrophy Reviewed

Tsunoda Ayami, Iritani Shuji, Ozaki Norio

PSYCHOGERIATRICS Vol. 11 ( 3 ) page： 171-176 2011.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1479-8301.2011.00366.x

Web of Science
Possible association between ubiquitin-specific peptidase 46 gene and major depressive disorders in the Japanese population Reviewed

Fukuo Yasuhisa, Kishi Taro, Kushima Itaru, Yoshimura Reiji, Okochi Tomo, Kitajima Tsuyoshi, Matsunaga Shinji, Kawashima Kunihiro, Umene-Nakano Wakako, Naitoh Hiroshi, Inada Toshiya, Nakamura Jun, Ozaki Norio, Iwata Nakao

JOURNAL OF AFFECTIVE DISORDERS Vol. 133 ( 1-2 ) page： 150-157 2011.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jad.2011.04.020

Web of Science
DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression Reviewed

Fuchikami Manabu, Morinobu Shigeru, Segawa Masahiro, Okamoto Yasumasa, Yamawaki Shigeto, Ozaki Norio, Inoue Takeshi, Kusumi Ichiro, Koyama Tsukasa, Tsuchiyama Kounosuke, Terao Takeshi

PLOS ONE Vol. 6 ( 8 ) 2011.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0023881

Web of Science
Lack of association between translin-associated factor X gene (TSNAX) and methamphetamine dependence in the Japanese population Reviewed

Kishi Taro, Okochi Tomo, Kitajima Tsuyoshi, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Correll Christoph U., Iwata Nakao

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Vol. 35 ( 7 ) page： 1618-1622 2011.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pnpbp.2011.06.001

Web of Science
Variants of the RELA Gene are Associated with Schizophrenia and their Startle Responses Reviewed

Hashimoto Ryota, Ohi Kazutaka, Yasuda Yuka, Fukumoto Motoyuki, Yamamori Hidenaga, Takahashi Hidetoshi, Iwase Masao, Okochi Tomo, Kazui Hiroaki, Saitoh Osamu, Tatsumi Masahiko, Iwata Nakao, Ozaki Norio, Kamijima Kunitoshi, Kunugi Hiroshi, Takeda Masatoshi

NEUROPSYCHOPHARMACOLOGY Vol. 36 ( 9 ) page： 1921-1931 2011.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/npp.2011.78

Web of Science
Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population Reviewed

Yoshimura Tomoko, Usui Hinako, Takahashi Nagahide, Yoshimi Akira, Saito Shinichi, Aleksic Branko, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Ozaki Norio

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Vol. 35 ( 5 ) page： 1268-1272 2011.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pnpbp.2011.04.003

Web of Science
No association between the PCM1 gene and schizophrenia: A multi-center case-control study and a meta-analysis Reviewed

Hashimoto Ryota, Ohi Kazutaka, Yasuda Yuka, Fukumoto Motoyuki, Yamamori Hidenaga, Kamino Kouzin, Morihara Takashi, Iwase Masao, Kazui Hiroaki, Numata Shusuke, Ikeda Masashi, Ueno Shu-ichi, Ohmori Tetsuro, Iwata Nakao, Ozaki Norio, Takeda Masatoshi

SCHIZOPHRENIA RESEARCH Vol. 129 ( 1 ) page： 80-84 2011.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2011.03.024

Web of Science
Impairment of the tyrosine hydroxylase neuronal network in the orbitofrontal cortex of a genetically modified mouse model of schizophrenia Reviewed

Sekiguchi Hirotaka, Iritani Shuji, Habuchi Chikako, Torii Yohta, Kuroda Keisuke, Kaibuchi Kozo, Ozaki Norio

BRAIN RESEARCH Vol. 1392 page： 47-53 2011.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.brainres.2011.03.058

Web of Science
Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders Reviewed

Niwa Minae, Matsumoto Yurie, Mouri Akihiro, Ozaki Norio, Nabeshima Toshitaka

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY Vol. 14 ( 4 ) page： 459-477 2011.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1017/S1461145710001239

Web of Science
Long-lasting effects of inescapable-predator stress on brain tryptophan metabolism and the behavior of juvenile mice Reviewed

Miura Hideki, Ando Yu, Noda Yukihiro, Isobe Kenichi, Ozaki Norio

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS Vol. 14 ( 3 ) page： 262-272 2011.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3109/10253890.2010.541539

Web of Science
SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study Reviewed

Kishi T., Fukuo Y., Kitajima T., Okochi T., Yamanouchi Y., Kinoshita Y., Kawashima K., Inada T., Kunugi H., Kato T., Yoshikawa T., Ujike H., Ozaki N., Iwata N.

GENES BRAIN AND BEHAVIOR Vol. 10 ( 3 ) page： 257-263 2011.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1601-183X.2010.00661.x

Web of Science
Association of ANK3 With Bipolar Disorder Confirmed in East Asia Reviewed

Takata Atsushi, Kim Se Hyun, Ozaki Norio, Iwata Nakao, Kunugi Hiroshi, Inada Toshiya, Ujike Hiroshi, Nakamura Kazuhiko, Mori Norio, Ahn Yong Min, Joo Eun-Jeong, Song Joo Yun, Kanba Shigenobu, Yoshikawa Takeo, Kim Yong Sik, Kato Tadafumi

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 156B ( 3 ) page： 312-315 2011.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.31164

Web of Science
Genome-Wide Association Study of Schizophrenia in a Japanese Population Reviewed

Ikeda Masashi, Aleksic Branko, Kinoshita Yoko, Okochi Tomo, Kawashima Kunihiro, Kushima Itaru, Ito Yoshihito, Nakamura Yukako, Kishi Taro, Okumura Takenori, Fukuo Yasuhisa, Williams Hywel J., Hamshere Marian L., Ivanov Dobril, Inada Toshiya, Suzuki Michio, Hashimoto Ryota, Ujike Hiroshi, Takeda Masatoshi, Craddock Nick, Kaibuchi Kozo, Owen Michael J., Ozaki Norio, O'Donovan Michael C., Iwata Nakao

BIOLOGICAL PSYCHIATRY Vol. 69 ( 5 ) page： 472-478 2011.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.biopsych.2010.07.010

Web of Science
Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence Reviewed

Kishi Taro, Kitajima Tsuyoshi, Kawashima Kunihiro, Okochi Tomo, Yamanouchi Yoshio, Kinoshita Yoko, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

CURRENT NEUROPHARMACOLOGY Vol. 9 ( 1 ) page： 129-132 2011.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association Study of Serine Racemase Gene with Methamphetamine Psychosis Reviewed

Yokobayashi E., Ujike H., Kotaka T., Okahisa Y., Takaki M., Kodama M., Inada T., Uchimura N., Yamada M., Iwata N., Iyo M., Sora I., Ozaki N., Kuroda S.

CURRENT NEUROPHARMACOLOGY Vol. 9 ( 1 ) page： 169-175 2011.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association Study of Two Cannabinoid Receptor Genes, CNR1 and CNR2, with Methamphetamine Dependence Reviewed

Okahisa Y., Kodama M., Takaki M., Inada T., Uchimura N., Yamada M., Iwata N., Iyo M., Sora I., Ozaki N., Ujike H.

CURRENT NEUROPHARMACOLOGY Vol. 9 ( 1 ) page： 183-189 2011.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association between the Regulator of G-protein Signaling 9 Gene and Patients with Methamphetamine Use Disorder and Schizophrenia Reviewed

Okahisa Y., Kodama M., Takaki M., Inada T., Uchimura N., Yamada M., Iwata N., Iyo M., Sora I., Ozaki N., Ujike H.

CURRENT NEUROPHARMACOLOGY Vol. 9 ( 1 ) page： 190-194 2011.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association Between 5HT1b Receptor Gene and Methamphetamine Dependence Reviewed

Ujike H., Kishimoto M., Okahisa Y., Kodama M., Takaki M., Inada T., Uchimura N., Yamada M., Iwata N., Iyo M., Sora I., Ozaki N.

CURRENT NEUROPHARMACOLOGY Vol. 9 ( 1 ) page： 163-168 2011.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association Analysis of the Tryptophan Hydroxylase 2 Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis Reviewed

Kobayashi Hideaki, Ujike Hiroshi, Iwata Nakao, Inada Toshiya, Yamada Mitsuhiko, Sekine Yoshimoto, Uchimura Naohisa, Iyo Masaomi, Ozaki Norio, Itokawa Masanari, Sora Ichiro

CURRENT NEUROPHARMACOLOGY Vol. 9 ( 1 ) page： 176-182 2011.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association Analysis of the Adenosine A1 Receptor Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis Reviewed

Kobayashi Hideaki, Ujike Hiroshi, Iwata Nakao, Inada Toshiya, Yamada Mitsuhiko, Sekine Yoshimoto, Uchimura Naohisa, Iyo Masaomi, Ozaki Norio, Itokawa Masanari, Sora Ichiro

CURRENT NEUROPHARMACOLOGY Vol. 9 ( 1 ) page： 137-142 2011.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese Reviewed

Okumura Takenori, Okochi Tomo, Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Kinoshita Yoko, Kawashima Kunihiro, Tsunoka Tomoko, Fukuo Yasuhisa, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Ujike Hiroshi, Iwata Nakao

CURRENT NEUROPHARMACOLOGY Vol. 9 ( 1 ) page： 155-159 2011.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese Reviewed

Okochi T., Kishi T., Ikeda M., Kitajima T., Kinoshita Y., Kawashima K., Okumura T., Tsunoka T., Fukuo Y., Inada T., Yamada M., Uchimura N., Iyo M., Sora I., Ozaki N., Ujike H., Iwata N.

CURRENT NEUROPHARMACOLOGY Vol. 9 ( 1 ) page： 151-154 2011.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Lack of Association Between Prokineticin 2 Gene and Japanese Methamphetamine Dependence Reviewed

Kishi Taro, Kitajima Tsuyoshi, Tsunoka Tomoko, Okumura Takenori, Kawashima Kunihiro, Okochi Tomo, Yamanouchi Yoshio, Kinoshita Yoko, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

CURRENT NEUROPHARMACOLOGY Vol. 9 ( 1 ) page： 133-136 2011.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
No Association Between GRM3 and Japanese Methamphetamine-Induced Psychosis Reviewed

Tsunoka Tomoko, Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Inada Toshiya, Ujike Hiroshi, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

CURRENT NEUROPHARMACOLOGY Vol. 9 ( 1 ) page： 160-162 2011.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Clinicopathological study of diffuse neurofibrillary tangles with calcification With special reference to TDP-43 proteinopathy and alpha-synucleinopathy Reviewed

Habuchi Chikako, Iritani Shuji, Sekiguchi Hirotaka, Torii Youta, Ishihara Ryoko, Arai Tetsuaki, Hasegawa Masato, Tsuchiya Kuniaki, Akiyama Haruhiko, Shibayama Hiroto, Ozaki Norio

JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 301 ( 1-2 ) page： 77-85 2011.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jns.2010.10.021

Web of Science
Serotonin 1A receptor gene, schizophrenia and bipolar disorder: An association study and meta-analysis Reviewed

Kishi Taro, Okochi Tomo, Tsunoka Tomoko, Okumura Takenori, Kitajima Tsuyoshi, Kawashima Kunihiro, Yamanouchi Yoshio, Kinoshita Yoko, Naitoh Hiroshi, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ujike Hiroshi, Ozaki Norio, Iwata Nakao

PSYCHIATRY RESEARCH Vol. 185 ( 1-2 ) page： 20-26 2011.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.psychres.2010.06.003

Web of Science
Serotonin 6 receptor gene is associated with methamphetamine-induced psychosis in a Japanese population Reviewed

Kishi Taro, Fukuo Yasuhisa, Okochi Tomo, Kitajima Tsuyoshi, Kawashima Kunihiro, Naitoh Hiroshi, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

DRUG AND ALCOHOL DEPENDENCE Vol. 113 ( 1 ) page： 1-7 2011.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.drugalcdep.2010.06.021

Web of Science
Depression associated with alcohol intake and younger age in Japanese office workers: A case-control and a cohort study Reviewed

Ogasawara Kazuyoshi, Nakamura Yukako, Aleksic Branko, Yoshida Keizo, Ando Katsuhisa, Iwata Nakao, Kayukawa Yuhei, Ozaki Norio

JOURNAL OF AFFECTIVE DISORDERS Vol. 128 ( 1-2 ) page： 33-40 2011.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jad.2010.06.015

Web of Science
The effects of mild cognitive impairment on driving performance in elderly drivers Reviewed

Kawano Naoko, Iwamoto Kunihiro, Sasada Kazumi, Kohmura Kunihiro, Yamamoto Maeri, Ebe Kazutoshi, Iidaka Tetsuya, Ozaki Norio

NEUROSCIENCE RESEARCH Vol. 71 page： E389-E389 2011

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neures.2011.07.1706

Web of Science
Necessity for ethical consideration of research in the aftermath of disaster Reviewed

Iijima Yoshihiko, Aleksic Branko, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 65 ( 5 ) page： 535-536 2011

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1440-1819.2011.02238.x

Web of Science
ONE NIGHT SLEEP RESTRICTION IMPAIRS THE CORTICAL OXYGENATION RESPONSES Reviewed

Miyata S., Noda A., Ito M., Iwamoto K., Ozaki N.

EUROPEAN PSYCHIATRY Vol. 26 page： . 2011

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Reliability and validity of a new sexual function questionnaire (Nagoya Sexual Function Questionnaire) for schizophrenic patients taking antipsychotics Reviewed

Kikuchi Tsutomu, Iwamoto Kunihiro, Sasada Kazumi, Aleksic Branko, Yoshida Keizo, Ozaki Norio

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 26 ( 4-5 ) page： 300-306 2011

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.1205

Web of Science
Proteomic analyses for identifying causative factors of schizophrenia and bipolar disorder Reviewed

Ohashi Mitsuki, Yamada Shinnnosuke, Yoshimi Akira, Ishihara Ryoko, Nagai Taku, Yamada Kiyofumi, Noda Yukihiro, Ozaki Norio

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 115 page： 142P-142P 2011

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Protein tyrosine phosphatase alpha as novel candidate molecule for the etiopathology of schizophrenia: Genetic analysis and biological implications Reviewed

Ozaki Norio

NEUROSCIENCE RESEARCH Vol. 71 page： E27-E27 2011

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neures.2011.07.116

Web of Science
Social defeat stress during juvenile stage impaired social behaviors associated with alternation of brain monoaminergic functions Reviewed

Ando Yu, Mouri Akihiro, Hida Hirotake, Waki Yukari, Yoshimi Akira, Nabeshima Toshitaka, Ozaki Norio, Noda Yukihiro

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 115 page： 250P-250P 2011

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
The CLOCK Gene and Mood Disorders: A Case-Control Study and Meta-analysis Reviewed

Kishi Taro, Yoshimura Reiji, Fukuo Yasuhisa, Kitajima Tsuyoshi, Okochi Tomo, Matsunaga Shinji, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ujike Hiroshi, Umene-Nakano Wakako, Nakamura Jun, Ozaki Norio, Serretti Alessandro, Correll Christoph U., Iwata Nakao

CHRONOBIOLOGY INTERNATIONAL Vol. 28 ( 9 ) page： 825-833 2011

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3109/07420528.2011.609951

Web of Science
Variants of the RELA gene are associated with schizophrenia and prepulse inhibition Reviewed

Hashimoto Ryota, Ohi Kazutaka, Yasuda Yuka, Fukumoto Motoyuki, Yamamori Hidenaga, Takahashi Hidetoshi, Iwase Masao, Okochi Tomo, Kazui Hiroaki, Saitoh Osamu, Tatsumi Masahiko, Iwata Nakao, Ozaki Norio, Kamijima Kunitoshi, Kunugi Hiroshi, Takeda Masatoshi

NEUROSCIENCE RESEARCH Vol. 71 page： E395-E395 2011

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neures.2011.07.1733

Web of Science
"Rework Program" in Japan: Innovative high-level rehabilitation Reviewed

Akiyama Tsuyoshi, Tsuchiya Masao, Igarashi Yoshio, Ozaki Norio, Yokoyama Motonori, Katagiri Yoko, Tajima Miyuki, Matsunaga Miki, Kitagawa Nobuki, Nakamoto Haruo, Ohno Yutaka, Bernick Peter

ASIA-PACIFIC PSYCHIATRY Vol. 2 ( 4 ) page： 208-216 2010.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1758-5872.2010.00093.x

Web of Science
Gene-wide association study between the methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population, with an updated meta-analysis on currently available data Reviewed

Yoshimi Akira, Aleksic Branko, Kawamura Yukiko, Takahashi Nagahide, Yamada Shinnosuke, Usui Hinako, Saito Shinichi, Ito Yoshihito, Iwata Nakao, Inada Toshiya, Noda Yukihiro, Yamada Kiyofumi, Ozaki Norio

SCHIZOPHRENIA RESEARCH Vol. 124 ( 1-3 ) page： 216-222 2010.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2010.07.011

Web of Science
Influence of HTR2A polymorphisms and parental rearing on personality traits in healthy Japanese subjects Reviewed

Nakamura Yukako, Ito Yoshihito, Aleksic Branko, Kushima Itaru, Yasui-Furukori Norio, Inada Toshiya, Ono Yutaka, Ozaki Norio

JOURNAL OF HUMAN GENETICS Vol. 55 ( 12 ) page： 838-841 2010.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/jhg.2010.110

Web of Science
Immunohistochemical Study of Vesicle Monoamine Transporter 2 in the Hippocampal Region of Genetic Animal Model of Schizophrenia Reviewed

Iritani Shuji, Sekiguchi Hirotaka, Habuchi Chikako, Hikita Takao, Taya Shinichiro, Kaibuchi Kozo, Ozaki Norio

SYNAPSE Vol. 64 ( 12 ) page： 948-953 2010.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/syn.20846

Web of Science
A case of dementia with Lewy bodies that temporarily showed symptoms similar to Creutzfeldt-Jakob disease Reviewed

Ukai Katsuyuki, Matsuo Koji, Nakamura Ryoichi, Sobue Gen, Kosaka Kenji, Shibayama Hiroto, Iritani Shuji, Ishihara Ryoko, Ozaki Norio

PSYCHOGERIATRICS Vol. 10 ( 4 ) page： 201-205 2010.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1479-8301.2010.00336.x

Web of Science
Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems Reviewed

Noda Yukihiro, Mouri Akihiro, Ando Yu, Waki Yukari, Yamada Shin-Nosuke, Yoshimi Akira, Yamada Kiyofumi, Ozaki Norio, Wang Dayong, Nabeshima Toshitaka

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY Vol. 13 ( 10 ) page： 1343-1354 2010.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1017/S1461145710000222

Web of Science
SIRT1 gene is associated with major depressive disorder in the Japanese population Reviewed

Kishi Taro, Yoshimura Reiji, Kitajima Tsuyoshi, Okochi Tomo, Okumura Takenori, Tsunoka Tomoko, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Fukuo Yasuhisa, Naitoh Hiroshi, Umene-Nakano Wakako, Inada Toshiya, Nakamura Jun, Ozaki Norio, Iwata Nakao

JOURNAL OF AFFECTIVE DISORDERS Vol. 126 ( 1-2 ) page： 167-173 2010.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jad.2010.04.003

Web of Science
Immunohistochemical study of vesicle monoamine transporter 2 in the hippocampal formation of PCP-treated mice Reviewed

Iritani Shuji, Sekiguchi Hirotaka, Habuchi Chikako, Torii Youta, Yamada Shinnosuke, Waki Yukari, Noda Yukihiro, Furukawa Hiroshi, Nabeshima Toshitaka, Ozaki Norio

NEUROSCIENCE RESEARCH Vol. 68 ( 2 ) page： 125-130 2010.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neures.2010.06.005

Web of Science
An association study between the dymeclin gene and schizophrenia in the Japanese population Reviewed

Yazaki Saori, Koga Minori, Ishiguro Hiroki, Inada Toshiya, Ujike Hiroshi, Itokawa Masanari, Otowa Takeshi, Watanabe Yuichiro, Someya Toshiyuki, Iwata Nakao, Kunugi Hiroshi, Ozaki Norio, Arinami Tadao

JOURNAL OF HUMAN GENETICS Vol. 55 ( 9 ) page： 631-634 2010.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/jhg.2010.72

Web of Science
Transient Neural Activation in Human Amygdala Involved in Aversive Conditioning of Face and Voice Reviewed

Iidaka Tetsuya, Saito Daisuke N., Komeda Hidetsugu, Mano Yoko, Kanayama Noriaki, Osumi Takahiro, Ozaki Norio, Sadato Norihiro

JOURNAL OF COGNITIVE NEUROSCIENCE Vol. 22 ( 9 ) page： 2074-2085 2010.9

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
HTR2A is Associated with SSRI Response in Major Depressive Disorder in a Japanese Cohort Reviewed

Kishi Taro, Yoshimura Reiji, Kitajima Tsuyoshi, Okochi Tomo, Okumura Takenori, Tsunoka Tomoko, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Naitoh Hiroshi, Nakamura Jun, Ozaki Norio, Iwata Nakao

NEUROMOLECULAR MEDICINE Vol. 12 ( 3 ) page： 237-242 2010.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s12017-009-8105-y

Web of Science
Lack of Association Between MAGEL2 and Schizophrenia and Mood Disorders in the Japanese Population Reviewed

Fukuo Yasuhisa, Kishi Taro, Okochi Tomo, Kitajima Tsuyoshi, Tsunoka Tomoko, Okumukura Takenori, Kinoshita Yoko, Kawashima Kunihiro, Yamanouchi Yoshio, Umene-Nakano Wakako, Naitoh Hiroshi, Inada Toshiya, Yoshimura Reiji, Nakamura Jun, Ozaki Norio, Iwata Nakao

NEUROMOLECULAR MEDICINE Vol. 12 ( 3 ) page： 285-291 2010.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s12017-010-8116-8

Web of Science
The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population Reviewed

Kobayashi Hideaki, Ujike Hiroshi, Iwata Nakao, Inada Toshiya, Yamada Mitsuhiko, Sekine Yoshimoto, Uchimura Naohisa, Iyo Masaomi, Ozaki Norio, Itokawa Masanari, Sora Ichiro

BEHAVIORAL AND BRAIN FUNCTIONS Vol. 6 2010.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/1744-9081-6-50

Web of Science
PROKR2 is associated with methamphetamine dependence in the Japanese population Reviewed

Kishi Taro, Kitajima Tsuyoshi, Tsunoka Tomoko, Okumura Takenori, Okochi Tomo, Kawashima Kunihiro, Inada Toshiya, Ujike Hiroshi, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Vol. 34 ( 6 ) page： 1033-1036 2010.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pnpbp.2010.05.018

Web of Science
Pharmacogenetic study of serotonin 6 receptor gene with antidepressant response in major depressive disorder in the Japanese population Reviewed

Kishi Taro, Fukuo Yasuhisa, Yoshimura Reiji, Okochi Tomo, Kitajima Tsuyoshi, Naitoh Hiroshi, Umene-Nakano Wakako, Nakamura Jun, Ozaki Norio, Iwata Nakao

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 25 ( 6 ) page： 481-486 2010.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.1142

Web of Science
Supportive Evidence for Reduced Expression of GNB1L in Schizophrenia Reviewed

Ishiguro Hiroki, Koga Minori, Horiuchi Yasue, Noguchi Emiko, Morikawa Miyuki, Suzuki Yoshimi, Arai Makoto, Niizato Kazuhiro, Iritani Shyuji, Itokawa Masanari, Inada Toshiya, Iwata Nakao, Ozaki Norio, Ujike Hiroshi, Kunugi Hiroshi, Sasaki Tsukasa, Takahashi Makoto, Watanabe Yuichiro, Someya Toshiyuki, Kakita Akiyoshi, Takahashi Hitoshi, Nawa Hiroyuki, Arinami Tadao

SCHIZOPHRENIA BULLETIN Vol. 36 ( 4 ) page： 756-765 2010.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/schbul/sbn160

Web of Science
Serotonin 6 receptor gene and mood disorders: Case-control study and meta-analysis Reviewed

Fukuo Yasuhisa, Kishi Taro, Yoshimura Reiji, Kitajima Tsuyoshi, Okochi Tomo, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Naitoh Hiroshi, Umene-Nakano Wakako, Inada Toshiya, Kunugi Hiroshi, Kato Tadafumi, Yoshikawa Takeo, Ujike Hiroshi, Nakamura Jun, Ozaki Norio, Iwata Nakao

NEUROSCIENCE RESEARCH Vol. 67 ( 3 ) page： 250-255 2010.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neures.2010.04.003

Web of Science
White matter microstructure of the cingulum and cerebellar peduncle is related to sustained attention and working memory: A diffusion tensor imaging study Reviewed

Takahashi Masahiro, Iwamoto Kunihiro, Fukatsu Hiroshi, Naganawa Shinji, Iidaka Tetsuya, Ozaki Norio

NEUROSCIENCE LETTERS Vol. 477 ( 2 ) page： 72-76 2010.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2010.04.031

Web of Science
Association analysis of SIGMAR1 with major depressive disorder and SSRI response Reviewed

Kishi Taro, Yoshimura Reiji, Okochi Tomo, Fukuo Yasuhisa, Kitajima Tsuyoshi, Okumura Takenori, Tsunoka Tomoko, Kawashima Kunihiro, Yamanouchi Yoshio, Kinoshita Yoko, Umene-Nakano Wakako, Naitoh Hiroshi, Nakamura Jun, Ozaki Norio, Iwata Nakao

NEUROPHARMACOLOGY Vol. 58 ( 7 ) page： 1168-1173 2010.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neuropharm.2010.02.013

Web of Science
Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures Reviewed

Takahashi Makoto, Hayashi Hiroshi, Watanabe Yuichiro, Sawamura Kazushi, Fukui Naoki, Watanabe Junzo, Kitajima Tsuyoshi, Yamanouchi Yoshio, Iwata Nakao, Mizukami Katsuyoshi, Hori Takafumi, Shimoda Kazutaka, Ujike Hiroshi, Ozaki Norio, Iijima Kentarou, Takemura Kazuo, Aoshima Hideyuki, Someya Toshiyuki

SCHIZOPHRENIA RESEARCH Vol. 119 ( 1-3 ) page： 210-218 2010.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2009.12.024

Web of Science
Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population Reviewed

Tsunoka Tomoko, Kishi Taro, Kitajima Tsuyoshi, Okochi Tomo, Okumura Takenori, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Naitoh Hiroshi, Inada Toshiya, Ujike Hiroshi, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Vol. 34 ( 4 ) page： 639-644 2010.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pnpbp.2010.03.002

Web of Science
Brain Cannabinoid CB2 Receptor in Schizophrenia Reviewed

Ishiguro Hiroki, Horiuchi Yasue, Ishikawa Maya, Koga Minori, Imai Keiko, Suzuki Yoshimi, Morikawa Miyuki, Inada Toshiya, Watanabe Yuichiro, Takahashi Makoto, Someya Toshiyuki, Ujike Hiroshi, Iwata Nakao, Ozaki Norio, Onaivi Emmanuel S., Kunugi Hiroshi, Sasaki Tsukasa, Itokawa Masanari, Arai Makoto, Niizato Kazuhiro, Iritani Shyuji, Naka Izumi, Ohashi Jun, Kakita Akiyoshi, Takahashi Hitoshi, Nawa Hiroyuki, Arinami Tadao

BIOLOGICAL PSYCHIATRY Vol. 67 ( 10 ) page： 974-982 2010.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.biopsych.2009.09.024

Web of Science
No association between DAO and schizophrenia in a Japanese patient population: A multicenter replication study Reviewed

Ohnuma Tohru, Shibata Nobuto, Baba Hajime, Ohi Kazutaka, Yasuda Yuka, Nakamura Yukako, Okochi Tomo, Naitoh Hiroshi, Hashimoto Ryota, Iwata Nakao, Ozaki Norio, Takeda Masatoshi, Arai Heii

SCHIZOPHRENIA RESEARCH Vol. 118 ( 1-3 ) page： 300-302 2010.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2010.01.028

Web of Science
Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: A three-stage case-control association study Reviewed

Amagane Hideki, Watanabe Yuichiro, Kaneko Naoshi, Nunokawa Ayako, Muratake Tatsuyuki, Ishiguro Hiroki, Arinami Tadao, Ujike Hiroshi, Inada Toshiya, Iwata Nakao, Kunugi Hiroshi, Sasaki Tsukasa, Hashimoto Ryota, Itokawa Masanari, Ozaki Norio, Someya Toshiyuki

SCHIZOPHRENIA RESEARCH Vol. 118 ( 1-3 ) page： 106-112 2010.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2010.01.023

Web of Science
Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population Reviewed

Aleksic Branko, Kushima Itaru, Ito Yoshihito, Nakamura Yukako, Ujike Hiroshi, Suzuki Michio, Inada Toshiya, Hashimoto Ryota, Takeda Masatoshi, Iwata Nakao, Ozaki Norio

SCHIZOPHRENIA RESEARCH Vol. 118 ( 1-3 ) page： 113-117 2010.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2010.01.014

Web of Science
The effects of acute treatment with tandospirone, diazepam, and placebo on driving performance and cognitive function in healthy volunteers Reviewed

Takahashi Masahiro, Iwamoto Kunihiro, Kawamura Yukiko, Nakamura Yukako, Ishihara Ryoko, Uchiyama Yuji, Ebe Kazutoshi, Noda Akiko, Noda Yukihiro, Yoshida Keizo, Iidaka Tetsuya, Ozaki Norio

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 25 ( 3 ) page： 260-267 2010.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.1105

Web of Science
Association of the HSPG2 Gene with Neuroleptic-Induced Tardive Dyskinesia Reviewed

Syu Aoi, Ishiguro Hiroki, Inada Toshiya, Horiuchi Yasue, Tanaka Syunsuke, Ishikawa Maya, Arai Makoto, Itokawa Masanari, Niizato Kazuhiro, Iritani Shuji, Ozaki Norio, Takahashi Makoto, Kakita Akiyoshi, Takahashi Hitoshi, Nawa Hiroyuki, Keino-Masu Kazuko, Arikawa-Hirasawa Eri, Arinami Tadao

NEUROPSYCHOPHARMACOLOGY Vol. 35 ( 5 ) page： 1155-1164 2010.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/npp.2009.220

Web of Science
Association Study of Bromodomain-Containing 1 Gene With Schizophrenia in Japanese Population Reviewed

Kushima Itaru, Aleksic Branko, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Ito Yoshihito, Nakamura Yukako, Inada Toshiya, Iwata Nakao, Ozaki Norio

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 153B ( 3 ) page： 786-791 2010.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.31048

Web of Science
A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls Reviewed

Hashimoto Ryota, Noguchi Hiroko, Hori Hiroaki, Nakabayashi Tetsuo, Suzuki Tatsuyo, Iwata Nakao, Ozaki Norio, Kosuga Asako, Tatsumi Masahiko, Kamijima Kunitoshi, Harada Seiichi, Takeda Masatoshi, Saitoh Osamu, Kunugi Hiroshi

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY Vol. 11 ( 2 ) page： 431-438 2010.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3109/15622970902736503

Web of Science
Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population Reviewed

Kushima Itaru, Aleksic Branko, Ito Yoshihito, Nakamura Yukako, Nakamura Kazuhiko, Mori Norio, Kikuchi Mitsuru, Inada Toshiya, Kunugi Hiroshi, Nanko Shinichiro, Kato Tadafumi, Yoshikawa Takeo, Ujike Hiroshi, Suzuki Michio, Iwata Nakao, Ozaki Norio

JOURNAL OF HUMAN GENETICS Vol. 55 ( 3 ) page： 133-136 2010.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/jhg.2009.139

Web of Science
Translin-Associated Factor X Gene (TSNAX) may be Associated with Female major Depressive Disorder in the Japanese Population Reviewed

Okuda Akiko, Kishi Taro, Okochi Tomo, Ikeda Masashi, Kitajima Tsuyoshi, Tsunoka Tomoko, Okumukura Takenori, Fukuo Yasuhisa, Kinoshita Yoko, Kawashima Kunihiro, Yamanouchi Yoshio, Inada Toshiya, Ozaki Norio, Iwata Nakao

NEUROMOLECULAR MEDICINE Vol. 12 ( 1 ) page： 78-85 2010.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s12017-009-8090-1

Web of Science
Association Analyses Between Brain-Expressed Fatty-Acid Binding Protein (FABP) Genes and Schizophrenia and Bipolar Disorder Reviewed

Iwayama Yoshimi, Hattori Eiji, Maekawa Motoko, Yamada Kazuo, Toyota Tomoko, Ohnishi Tetsuo, Iwata Yasuhide, Tsuchiya Kenji J., Sugihara Genichi, Kikuchi Mitsuru, Hashimoto Kenji, Iyo Masaomi, Inada Toshiya, Kunugi Hiroshi, Ozaki Norio, Iwata Nakao, Nanko Shinichiro, Iwamoto Kazuya, Okazaki Yuji, Kato Tadafumi, Yoshikawa Takeo

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 153B ( 2 ) page： 484-493 2010.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.31004

Web of Science
Identification of Novel Candidate Genes for Treatment Response to Risperidone and Susceptibility for Schizophrenia: Integrated Analysis Among Pharmacogenomics, Mouse Expression, and Genetic Case-Control Association Approaches Masashi Ikeda Reviewed

Ikeda Masashi, Tomita Yasuyuki, Mouri Akihiro, Koga Minori, Okochi Tomo, Yoshimura Reiji, Yamanouchi Yoshio, Kinoshita Yoko, Hashimoto Ryota, Williams Hywel J., Takeda Masatoshi, Nakamura Jun, Nabeshima Toshitaka, Owen Michael J., O'Donovan Michael C., Honda Hiroyuki, Arinami Tadao, Ozaki Norio, Iwata Nakao

BIOLOGICAL PSYCHIATRY Vol. 67 ( 3 ) page： 263-269 2010.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.biopsych.2009.08.030

Web of Science
Copy Number Variation in Schizophrenia in the Japanese Population Reviewed

Ikeda Masashi, Aleksic Branko, Kirov George, Kinoshita Yoko, Yamanouchi Yoshio, Kitajima Tsuyoshi, Kawashima Kunihiro, Okochi Tomo, Kishi Taro, Zaharieva Irina, Owen Michael J., O'Donovan Michael C., Ozaki Norio, Iwata Nakao

BIOLOGICAL PSYCHIATRY Vol. 67 ( 3 ) page： 283-286 2010.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.biopsych.2009.08.034

Web of Science
The chitinase 3-like 1 gene and schizophrenia: Evidence from a multi-center case-control study and meta-analysis Reviewed

Ohi Kazutaka, Hashimoto Ryota, Yasuda Yuka, Yoshida Tetsuhiko, Takahashi Hidetoshi, Iike Naomi, Iwase Masao, Kamino Kouzin, Ishii Ryouhei, Kazui Hiroaki, Fukumoto Motoyuki, Takamura Hironori, Yamamori Hidenaga, Azechi Michiyo, Ikezawa Koji, Tanimukai Hitoshi, Tagami Shinji, Morihara Takashi, Okochi Masayasu, Yamada Kazuo, Numata Shusuke, Ikeda Masashi, Tanaka Toshihisa, Kudo Takashi, Ueno Shu-ichi, Yoshikawa Takeo, Ohmori Tetsuro, Iwata Nakao, Ozaki Norio, Takeda Masatoshi

SCHIZOPHRENIA RESEARCH Vol. 116 ( 2-3 ) page： 126-132 2010.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2009.12.002

Web of Science
Measurement limit of quality-of-life questionnaires in psychiatric settings Reviewed

Nishiyama Takeshi, Ozaki Norio

QUALITY OF LIFE RESEARCH Vol. 19 ( 1 ) page： 25-30 2010.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s11136-009-9556-1

Web of Science
Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients Reviewed

Kishi Taro, Tsunoka Tomoko, Ikeda Masashi, Kitajima Tsuyoshi, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Yamanouchi Yoshio, Kinoshita Yoko, Ujike Hiroshi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

NEUROPHARMACOLOGY Vol. 58 ( 2 ) page： 452-456 2010.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neuropharm.2009.09.006

Web of Science
Insufficient sleep impairs driving performance and cognitive function Reviewed

Miyata Seiko, Noda Akiko, Ozaki Norio, Hara Yuki, Minoshima Makoto, Iwamoto Kunihiro, Takahashi Masahiro, Iidaka Tetsuya, Koike Yasuo

NEUROSCIENCE LETTERS Vol. 469 ( 2 ) page： 229-233 2010.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2009.12.001

Web of Science
Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder Reviewed

Hashimoto Ryota, Hashimoto Hitoshi, Shintani Norihito, Ohi Kazutaka, Hori Hiroaki, Saitoh Osamu, Kosuga Asako, Tatsumi Masahiko, Iwata Nakao, Ozaki Norio, Kamijima Kunitoshi, Baba Akemichi, Takeda Masatoshi, Kunugi Hiroshi

NEUROSCIENCE LETTERS Vol. 468 ( 3 ) page： 300-302 2010.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2009.11.019

Web of Science
The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: Case-control studies and an updated meta-analysis Reviewed

Nunokawa Ayako, Watanabe Yuichiro, Kaneko Naoshi, Sugai Takuro, Yazaki Saori, Arinami Tadao, Ujike Hiroshi, Inada Toshiya, Iwata Nakao, Kunugi Hiroshi, Sasaki Tsukasa, Itokawa Masanari, Ozaki Norio, Hashimoto Ryota, Someya Toshiyuki

SCHIZOPHRENIA RESEARCH Vol. 116 ( 1 ) page： 61-67 2010.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2009.10.016

Web of Science
A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects Reviewed

Koide, Takayoshi; Aleksic, Branko; Ito, Yoshihito; Usui, Hinako; Yoshimi, Akira; Inada, Toshiya; Suzuki, Michio; Hashimoto, Ryota; Takeda, Masatoshi; Iwata, Nakao; Ozaki, Norio

JOURNAL OF HUMAN GENETICS Vol. 55 ( 7 ) page： 469-472 2010

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/jhg.2010.38

Web of Science
Comparison of pharmacological profiles of serotonin norepinephrine reuptake inhibitors

Adachi, Y. Aleksic, B. Ozaki, N.

Clinical Neuropsychopharmacology and Therapeutics Vol. 1 page： 10-15 2010

　More details

Language：English Publishing type：Research paper (scientific journal)
Effectiveness of Milnacipran for the Treatment of Chronic Pain in the Orofacial Region Reviewed

Ito Mikiko, Kimura Hiroyuki, Yoshida Keizo, Kimura Yuki, Ozaki Norio, Kurita Kenichi

CLINICAL NEUROPHARMACOLOGY Vol. 33 ( 2 ) page： 79-83 2010

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/WNF.0b013e3181cb5793

Web of Science
Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder Reviewed

Okuda Akiko, Suzuki Tatsuyo, Kishi Taro, Yamanouchi Yoshio, Umeda Kazunori, Haitoh Hiroshi, Hashimoto Shuji, Ozaki Norio, Iwata Nakao

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 64 ( 3 ) page： 268-273 2010

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1440-1819.2010.02091.x

Web of Science
Genetic Association Analysis of Functional Polymorphisms in Neuronal Nitric Oxide Synthase 1 Gene (NOS1) and Mood Disorders and Fluvoxamine Response in Major Depressive Disorder in the Japanese Population Reviewed

Okumura Takenori, Kishi Taro, Okochi Tomo, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Tsunoka Tomoko, Inada Toshiya, Ozaki Norio, Iwata Nakao

NEUROPSYCHOBIOLOGY Vol. 61 ( 2 ) page： 57-63 2010

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1159/000265130

Web of Science
Influence of chronic social defeat stress during neurodevelopmental stage on social behaviors Reviewed

Ando Yu, Waki Yukari, Yamada Shinnosuke, Yoshimi Akira, Mouri Akihiro, Nabeshima Toshitaka, Ozaki Norio, Noda Yukihiro

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 112 page： 228P-228P 2010

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Proteomic approach for the identification of potential biomarkers in schizophrenia Reviewed

Yamada Shinnosuke, Nagai Taku, Yoshimi Akira, Ohashi Mitsuki, Ito Yoshihito, Noda Yukihiro, Ozaki Norio

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 112 page： 63P-63P 2010

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Relationship of psychopathological symptoms and cognitive function to subjective quality of life in patients with chronic schizophrenia Reviewed

Tomida Kenji, Takahashi Nagahide, Saito Shinichi, Maeno Nobuhisa, Iwamoto Kunihiro, Yoshido Keizo, Kimura Hiroyuki, Iidaka Tetsuya, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 64 ( 1 ) page： 62-69 2010

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1440-1819.2009.02033.x

Web of Science
The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment Reviewed

Schulze Thomas G., Alda Martin, Adli Mazda, Akula Nirmala, Ardau Raffaella, Bui Elise T., Chillotti Caterina, Cichon Sven, Czerski Piotr, Del Zompo Maria, Detera-Wadleigh Sevilla D., Grof Paul, Gruber Oliver, Hashimoto Ryota, Hauser Joanna, Hoban Rebecca, Iwata Nakao, Kassem Layla, Kato Tadafumi, Kittel-Schneider Sarah, Kliwicki Sebastian, Kelsoe John R., Kusumi Ichiro, Laje Gonzalo, Leckband Susan G., Manchia Mirko, MacQueen Glenda, Masui Takuya, Ozaki Norio, Perlis Roy H., Pfennig Andrea, Piccardi Paola, Richardson Sara, Rouleau Guy, Reif Andreas, Rybakowski Janusz K., Sasse Johanna, Schumacher Johannes, Severino Giovanni, Smoller Jordan W., Squassina Alessio, Turecki Gustavo, Young L. Trevor, Yoshikawa Takeo, Bauer Michael, McMahon Francis J.

NEUROPSYCHOBIOLOGY Vol. 62 ( 1 ) page： 72-78 2010

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1159/000314708

Web of Science
The expression of HMGA1a is increased in lymphoblastoid cell lines from schizophrenia patients Reviewed

Morikawa Tomomi, Manabe Takayuki, Ito Yoshihito, Yamada Shinnosuke, Yoshimi Akira, Nagai Taku, Ozaki Norio, Mayeda Akila

NEUROCHEMISTRY INTERNATIONAL Vol. 56 ( 6-7 ) page： 736-739 2010

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neuint.2010.03.011

Web of Science
Preliminary Genome-Wide Association Study of Bipolar Disorder in the Japanese Population Reviewed

Hattori Eiji, Toyota Tomoko, Ishitsuka Yuichi, Iwayama Yoshimi, Yamada Kazuo, Ujike Hiroshi, Morita Yukitaka, Kodama Masafumi, Nakata Kenji, Minabe Yoshio, Nakamura Kazuhiko, Iwata Yasuhide, Takei Nori, Mori Norio, Naitoh Hiroshi, Yamanouchi Yoshio, Iwata Nakao, Ozaki Norio, Kato Tadafumi, Nishikawa Toru, Kashiwa Atsushi, Suzuki Mika, Shioe Kunihiko, Shinohara Manabu, Hirano Masami, Nanko Shinichiro, Akahane Akihisa, Ueno Mikako, Kaneko Naoshi, Watanabe Yuichiro, Someya Toshiyuki, Hashimoto Kenji, Iyo Masaomi, Itokawa Masanari, Arai Makoto, Nankai Masahiro, Inada Toshiya, Yoshida Sumiko, Kunugi Hiroshi, Nakamura Michiko, Iijima Yoshimi, Okazaki Yuji, Higuchi Teruhiko, Yoshikawa Takeo

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 150B ( 8 ) page： 1110-1117 2009.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30941

Web of Science
Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia Reviewed

Ueno Hitomi, Nishigaki Yutaka, Kong Qing-Peng, Fuku Noriyuki, Kojima Shuji, Iwata Nakao, Ozaki Norio, Tanaka Masashi

MITOCHONDRION Vol. 9 ( 6 ) page： 385-393 2009.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.mito.2009.06.003

Web of Science
Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis Reviewed

Kishi Taro, Tsunoka Tomoko, Ikeda Masashi, Kawashima Kunihiro, Okochi Tomo, Kitajima Tsuyoshi, Kinoshita Yoko, Okumura Takenori, Yamanouchi Yoshio, Inada Toshiya, Ozaki Norio, Iwata Nakao

JOURNAL OF HUMAN GENETICS Vol. 54 ( 11 ) page： 629-633 2009.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/jhg.2009.84

Web of Science
Gender difference in relationship between anxiety-related personality traits and cerebral brain glucose metabolism Reviewed

Hakamata Yuko, Iwase Mikio, Iwata Hiroshi, Kobayashi Toshiki, Tamaki Tsuneo, Nishio Masami, Matsuda Hiroshi, Ozaki Norio, Inada Toshiya

PSYCHIATRY RESEARCH-NEUROIMAGING Vol. 173 ( 3 ) page： 206-211 2009.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pscychresns.2008.10.002

Web of Science
No association between the Bcl2-interacting killer (BIK) gene and schizophrenia Reviewed

Ohi Kazutaka, Hashimoto Ryota, Yasuda Yuka, Yamamori Hidenaga, Hori Hiroaki, Saitoh Osamu, Tatsumi Masahiko, Takeda Masatoshi, Iwata Nakao, Ozaki Norio, Kamijima Kunitoshi, Kunugi Hiroshi

NEUROSCIENCE LETTERS Vol. 463 ( 1 ) page： 60-63 2009.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2009.07.063

Web of Science
Association of AKT1 with schizophrenia confirmed in a Japanese population (vol 56, pg 698, 2004) Reviewed

Ikeda M., Iwata N., Suzuki T., Kitajima T., Yamanouchi Y., Kinoshita Y., Inada T., Ozaki N.

BIOLOGICAL PSYCHIATRY Vol. 66 ( 5 ) page： 527-527 2009.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.biopsych.2009.07.012

Web of Science
The disrupted-in-schizophrenia-1 ser704cys polymorphism and brain morphology in schizophrenia Reviewed

Suzuki M., Takahashi T., Tsunoda M., Maeno N., Kawasaki Y., Zhou S., Tsuneki H., Kobayashi S., Kurachi M., Ozaki N.

EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 19 page： S305-S305 2009.9

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Expression of neprilysin, somatostatin and the somatostatin sst(5) receptor in the hippocampal formation of brains from Alzheimer's disease patients Reviewed

Sekiguchi Hirotaka, Habuchi Chikako, Iritani Shuji, Arai Tetsuaki, Ozaki Norio

PSYCHOGERIATRICS Vol. 9 ( 3 ) page： 132-138 2009.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1479-8301.2009.00285.x

Web of Science
G72 gene is associated with susceptibility to methamphetamine psychosis Reviewed

Kotaka Tatsuya, Ujike Hiroshi, Okahisa Yuko, Takaki Manabu, Nakata Kenji, Kodama Masafumi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Kuroda Shigetoshi

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Vol. 33 ( 6 ) page： 1046-1049 2009.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pnpbp.2009.05.017

Web of Science
A functional polymorphism in estrogen receptor alpha gene is associated with Japanese methamphetamine induced psychosis Reviewed

Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Tsunoka Tomoko, Okumura Takenori, Inada Toshiya, Ujike Hiroshi, Yamada Mitsuhiko, Uchimura Naohisa, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Iwata Nakao

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Vol. 33 ( 5 ) page： 895-898 2009.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pnpbp.2009.04.008

Web of Science
Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population Reviewed

Okochi Tomo, Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Kinoshita Yoko, Kawashima Kunihiro, Okumura Takenori, Tsunoka Tomoko, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Ujike Hiroshi, Iwata Nakao

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Vol. 33 ( 5 ) page： 903-905 2009.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pnpbp.2009.04.016

Web of Science
Association analysis of Group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population Reviewed

Tsunoka Tomoko, Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Inada Toshiya, Ozaki Norio, Iwata Nakao

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Vol. 33 ( 5 ) page： 875-879 2009.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pnpbp.2009.04.007

Web of Science
Association analysis of functional polymorphism in estrogen receptor alpha gene with schizophrenia and mood disorders in the Japanese population Reviewed

Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Tsunoka Tomoko, Inada Toshiya, Ozaki Norio, Iwata Nakao

PSYCHIATRIC GENETICS Vol. 19 ( 4 ) page： 217-218 2009.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/YPG.0b013e32832cee98

Web of Science
Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population Reviewed

Kishi Taro, Kitajima Tsuyoshi, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Tsunoka Tomoko, Inada Toshiya, Ozaki Norio, Iwata Nakao

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE Vol. 259 ( 5 ) page： 293-297 2009.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00406-009-0869-4

Web of Science
Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia Reviewed

Koga Minori, Ishiguro Hiroki, Yazaki Saori, Horiuchi Yasue, Arai Makoto, Niizato Kazuhiro, Iritani Shuji, Itokawa Masanari, Inada Toshiya, Iwata Nakao, Ozaki Norio, Ujike Hiroshi, Kunugi Hiroshi, Sasaki Tsukasa, Takahashi Makoto, Watanabe Yuichiro, Someya Toshiyuki, Kakita Akiyoshi, Takahashi Hitoshi, Nawa Hiroyuki, Muchardt Christian, Yaniv Moshe, Arinami Tadao

HUMAN MOLECULAR GENETICS Vol. 18 ( 13 ) page： 2483-2494 2009.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/hmg/ddp166

Web of Science
A two-stage case-control association study of PADI2 with schizophrenia Reviewed

Watanabe Yuichiro, Nunokawa Ayako, Kaneko Naoshi, Arinami Tadao, Ujike Hiroshi, Inada Toshiya, Iwata Nakao, Kunugi Hiroshi, Itokawa Masanari, Otowa Takeshi, Ozaki Norio, Someya Toshiyuki

JOURNAL OF HUMAN GENETICS Vol. 54 ( 7 ) page： 430-432 2009.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/jhg.2009.52

Web of Science
BDNF is not associated with schizophrenia: Data from a Japanese population study and meta-analysis Reviewed

Kawashima Kunihiro, Ikeda Masashi, Kishi Taro, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Okochi Tomo, Aleksic Branko, Tomita Makoto, Okada Takeya, Kunugi Hiroshi, Inada Toshiya, Ozaki Norio, Iwata Nakao

SCHIZOPHRENIA RESEARCH Vol. 112 ( 1-3 ) page： 72-79 2009.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2009.03.040

Web of Science
Tumor necrosis factor receptor-associated protein 1 regulates cell adhesion and synaptic morphology via modulation of N-cadherin expression Reviewed

Kubota Kyoko, Inoue Kiyoshi, Hashimoto Ryota, Kumamoto Natsuko, Kosuga Asako, Tatsumi Masahiko, Kamijima Kunitoshi, Kunugi Hiroshi, Iwata Nakao, Ozaki Norio, Takeda Masatoshi, Tohyama Masaya

JOURNAL OF NEUROCHEMISTRY Vol. 110 ( 2 ) page： 496-508 2009.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1471-4159.2009.06099.x

Web of Science
Genetic variants of D2 but not D3 or D4 dopamine receptor gene are associated with rapid onset and poor prognosis of methamphetamine psychosis Reviewed

Ujike Hiroshi, Katsu Takeshi, Okahisa Yuko, Takaki Manabu, Kodama Masafumi, Inada Toshiya, Uchimura Naohisa, Yamada Mitsuhiko, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Kuroda Shigetoshi

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Vol. 33 ( 4 ) page： 625-629 2009.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pnpbp.2009.02.019

Web of Science
Upper airway morphology in patients with obstructive sleep apnea syndrome: Effects of lateral positioning Reviewed

Soga Taro, Nakata Seiichi, Yasuma Fumihiko, Noda Akiko, Sugiura Tatsuki, Yatsuya Hiroshi, Koike Yasuo, Ozaki Norio, Nakashima Tsutomu

AURIS NASUS LARYNX Vol. 36 ( 3 ) page： 305-309 2009.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.anl.2008.04.007

Web of Science
Possible Association of Prokineticin 2 Receptor Gene (PROKR2) with Mood Disorders in the Japanese Population Reviewed

Kishi Taro, Kitajima Tsuyoshi, Tsunoka Tomoko, Okumura Takenori, Ikeda Masashi, Okochi Tomo, Kinoshita Yoko, Kawashima Kunihiro, Yamanouchi Yoshio, Ozaki Norio, Iwata Nakao

NEUROMOLECULAR MEDICINE Vol. 11 ( 2 ) page： 114-122 2009.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s12017-009-8067-0

Web of Science
CLOCK may Predict the Response to Fluvoxamine Treatment in Japanese Major Depressive Disorder Patients Reviewed

Kishi Taro, Kitajima Tsuyoshi, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Tsunoka Tomoko, Ozaki Norio, Iwata Nakao

NEUROMOLECULAR MEDICINE Vol. 11 ( 2 ) page： 53-57 2009.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s12017-009-8060-7

Web of Science
Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population Reviewed

Kishi Taro, Kitajima Tsuyoshi, Tsunoka Tomoko, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Inada Toshiya, Ozaki Norio, Iwata Nakao

NEUROSCIENCE RESEARCH Vol. 64 ( 2 ) page： 231-234 2009.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neures.2009.03.003

Web of Science
No Association Between Polymorphisms of Neuronal Oxide Synthase 1 Gene (NOS1) and Schizophrenia in a Japanese Population Reviewed

Okumura Takenori, Okochi Tomo, Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Tsunoka Tomoko, Ujike Hiroshi, Inada Toshiya, Ozaki Norio, Iwata Nakao

NEUROMOLECULAR MEDICINE Vol. 11 ( 2 ) page： 123-127 2009.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s12017-009-8068-z

Web of Science
An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis Reviewed

Nakamura Kazuhiko, Sekine Yoshimoto, Takei Noriyoshi, Iwata Yasuhide, Suzuki Katsuaki, Anitha Ayyappan, Inada Toshiya, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Iwata Nakao, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Ujike Hiroshi, Mori Norio

NEUROSCIENCE LETTERS Vol. 455 ( 2 ) page： 120-123 2009.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2009.02.048

Web of Science
Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia Reviewed

Shibata Hiroki, Tani Ayako, Chikuhara Tomoyuki, Kikuta Rumiko, Sakai Mayurril, Ninomiya Hideaki, Tashiro Nobutada, Iwata Nakao, Ozaki Norio, Fukumaki Yasuyuki

PSYCHIATRY RESEARCH Vol. 167 ( 1-2 ) page： 88-96 2009.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.psychres.2007.12.002

Web of Science
The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia Reviewed

Takahashi Tsutomu, Suzuki Michio, Tsunoda Masahiko, Maeno Nobuhisa, Kawasaki Yasuhiro, Zhou Shi-Yu, Hagino Hirofumi, Niu Lisha, Tsuneki Hiroshi, Kobayashi Soushi, Sasaoka Toshiyasu, Seto Hikaru, Kurachi Masayoshi, Ozaki Norio

PSYCHIATRY RESEARCH-NEUROIMAGING Vol. 172 ( 2 ) page： 128-135 2009.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pscychresns.2009.01.005

Web of Science
Meta-analysis of association between genetic variants in COMT and schizophrenia: An update Reviewed

Okochi Tomo, Ikeda Masashi, Kishi Taro, Kawashima Kunihiro, Kinoshita Yoko, Kitajima Tsuyoshi, Yamanouchi Yoshio, Tomita Makoto, Inada Toshiya, Ozaki Norio, Iwata Nakao

SCHIZOPHRENIA RESEARCH Vol. 110 ( 1-3 ) page： 140-148 2009.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2009.02.019

Web of Science
Association study of the G72 gene with schizophrenia in a Japanese population: A multicenter study Reviewed

Ohi Kazutaka, Hashimoto Ryota, Yasuda Yuka, Yoshida Tetsuhiko, Takahashi Hidetoshi, Iike Naomi, Fukumoto Motoyuki, Takamura Hironori, Iwase Masao, Kamino Kouzin, Ishii Ryouhei, Kazui Hiroaki, Sekiyama Ryuji, Kitamura Yuri, Azechi Michiyo, Ikezawa Koji, Kurimoto Ryu, Kamagata Eiichiro, Tanimukai Hitoshi, Tagami Shinji, Morihara Takashi, Ogasawara Masayuki, Okochi Masayasu, Tokunaga Hiromasa, Numata Shusuke, Ikeda Masashi, Ohnuma Tohru, Ueno Shu-ichi, Fukunaga Tomoko, Tanaka Toshihisa, Kudo Takashi, Arai Heii, Ohmori Tetsuro, Iwata Nakao, Ozaki Norio, Takeda Masatoshi

SCHIZOPHRENIA RESEARCH Vol. 109 ( 1-3 ) page： 80-85 2009.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2009.01.019

Web of Science
Association Study Between the PIK4CA Gene and Methamphetamine Use Disorder in a Japanese Population Reviewed

Kanahara Nobuhisa, Miyatake Ryosuke, Sekine Yoshimoto, Inada Toshiya, Ozaki Norio, Iwata Nakao, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Sora Ichiro, Ujike Hiroshi, Iyo Masaomi, Hashimoto Kenji

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 150B ( 2 ) page： 233-238 2009.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30797

Web of Science
Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia Reviewed

Arai Shinsaku, Shibata Hiroki, Sakai Mayumi, Ninomiya Hideaki, Iwata Nakao, Ozaki Norio, Fukumaki Yasuyuki

PSYCHIATRIC GENETICS Vol. 19 ( 1 ) page： 6-13 2009.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/YPG.0b013e328311875d

Web of Science
Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia Reviewed

Watanabe Yuichiro, Nunokawa Ayako, Kaneko Naoshi, Muratake Tatsuyuki, Arinami Tadao, Ujike Hiroshi, Inada Toshiya, Iwata Nakao, Kunugi Hiroshi, Itokawa Masanari, Otowa Takeshi, Ozaki Norio, Someya Toshiyuki

JOURNAL OF HUMAN GENETICS Vol. 54 ( 1 ) page： 62-65 2009.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/jhg.2008.4

Web of Science
A link between stress and depression: Shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression Reviewed

Miura Hideki, Ozaki Norio, Sawada Makoto, Isobe Kenichi, Ohta Tatsuro, Nagatsu Toshiharu

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS Vol. 12 ( 5 ) page： 198-209 2009

　More details

Language：English

DOI： 10.1080/10253890701754068

Web of Science
Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence Reviewed

Okahisa Yuko, Ujike Hiroshi, Kotaka Tatsuya, Morita Yukitaka, Kodama Masafumi, Inada Toshiya, Yamada Mitsuhiko, Iwata Nakao, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Kuroda Shigetoshi

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 63 ( 3 ) page： 417-422 2009

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1440-1819.2009.01961.x

Web of Science
Dense association mapping of dihydropyrimidinase-like 2 (DPYSL2) gene in susceptibility to schizophrenia in a Japanese population Reviewed

Ito Yoshihito, Koide Takayoshi, Aleksic Branko, Inada Toshiya, Iwata Nakao, Ozaki Norio

NEUROSCIENCE RESEARCH Vol. 65 page： S253-S253 2009

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neures.2009.09.1441

Web of Science
Distribution of neurofibrillary tangles in diffuse neurofibrillary tangles with calcification Reviewed

Ukai Katsuyuki, Shibayama Hiroto, Ishihara Ryoko, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 63 ( 5 ) page： 646-651 2009

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1440-1819.2009.02000.x

Web of Science
Orphan Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Fluvoxamine Response in Major Depressive Disorder in the Japanese Population Reviewed

Kishi Taro, Kitajima Tsuyoshi, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Ozaki Norio, Iwata Nakao

NEUROPSYCHOBIOLOGY Vol. 59 ( 4 ) page： 234-238 2009

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1159/000226612

Web of Science
Practice-based depression screening for psychiatry outpatients: Feasibility comparison of two-types of Center for Epidemiologic Studies Depression Scales Reviewed

Nishiyama Takeshi, Ozaki Norio, Iwata Nakao

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 63 ( 5 ) page： 632-638 2009

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1440-1819.2009.02003.x

Web of Science
Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice Reviewed

Miura Hideki, Shirokawa Tetsuya, Isobe Kenichi, Ozaki Norio

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS Vol. 12 ( 3 ) page： 206-214 2009

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1080/10253890802252442

Web of Science
The roles of glutamate transporter, GLAST in learning and memory, and emotion Reviewed

Waki Yukari, Murai Rina, Yoshimi Akira, Yamada Shinnosuke, Ando Yu, Mouri Akihiro, Ozaki Norio, Yamada Kiyofumi, Tanaka Kohichi, Noda Yukihiro, Nabeshima Toshitaka

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 109 page： 126P-126P 2009

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Sleep and lifestyle habits in morning and evening types of human circadian rhythm Reviewed

Sukegawa Mayo, Noda Akiko, Morishita Yuki, Ochi Hikari, Miyata Seiko, Honda Kumiko, Maeno Nobuhisa, Ozaki Norio, Koike Yasuo

BIOLOGICAL RHYTHM RESEARCH Vol. 40 ( 2 ) page： 121-127 2009

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1080/09291010701794404

Web of Science
Use of questionnaire infeasibility in order to detect cognitive disorders: Example of the Center for Epidemiologic Studies Depression Scale in psychiatry settings Reviewed

Nishiyama Takeshi, Ozaki Norio, Iwata Nakao

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 63 ( 1 ) page： 23-29 2009

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1440-1819.2008.01902.x

Web of Science
Association analysis between the protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) gene and schizophrenia in the Japanese population Reviewed

Yamada Shinnosuke, Ito Yoshihito, Yoshimi Akira, Noda Yukihiro, Ozaki Norio

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 109 page： 208P-208P 2009

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
A novel molecule 'shati' increases dopamine uptake via the induction of tumor necrosis factor-alpha in pheochromocytoma-12 cells Reviewed

Niwa Minae, Nitta Atsumi, Cen Xiaobo, Kitaichi Kiyoyuki, Ozaki Norio, Yamada Kiyofumi, Nabeshima Toshitaka

JOURNAL OF NEUROCHEMISTRY Vol. 107 ( 6 ) page： 1697-1708 2008.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1471-4159.2008.05738.x

Web of Science
Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population Reviewed

Kishi Taro, Kitajima Tsuyoshi, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Ozaki Norio, Iwata Nakao

NEUROSCIENCE RESEARCH Vol. 62 ( 4 ) page： 211-215 2008.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neures.2008.08.008

Web of Science
Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia Reviewed

Ikeda, Masashi; Hikita, Takao; Taya, Shinichiro; Uraguchi-Asaki, Junko; Toyo-oka, Kazuhito; Wynshaw-Boris, Anthony; Ujike, Hiroshi; Inada, Toshiya; Takao, Keizo; Miyakawa, Tsuyoshi; Ozaki, Norio; Kaibuchi, Kozo; Iwata, Nakao

HUMAN MOLECULAR GENETICS Vol. 17 ( 20 ) page： 3212-3222 2008.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/hmg/ddn217

Web of Science
No Association Between the Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 (PTPRZ1) Gene and Schizophrenia in the Japanese Population Reviewed

Ito Yoshihito, Yamada Shinnosuke, Takahashi Nagahide, Saito Shinichi, Yoshimi Akira, Inada Toshiya, Noda Yukihiro, Ozaki Norio

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 147B ( 7 ) page： 1013-1018 2008.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30692

Web of Science
Association Study Between Polymorphisms in Glutathione-Related Genes and Methamphetamine Use Disorder in a Japanese Population Reviewed

Hashimoto Tasuku, Hashimoto Kenji, Miyatake Ryosuke, Matsuzawa Daisuke, Sekine Yoshimoto, Inada Toshiya, Ozaki Norio, Iwata Nakao, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Sora Ichiro, Ujike Hiroshi, Iyo Masaomi

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 147B ( 7 ) page： 1040-1046 2008.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30703

Web of Science
No Association Between Tagging SNPs of SNARE Complex Genes (STX1A, VAMP2 and SNAP25) and Schizophrenia in a Japanese Population Reviewed

Kawashima Kunihiro, Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Takahashi Nagahide, Saito Shinichi, Ohi Kazutaka, Yasuda Yuka, Hashimoto Ryota, Takeda Masatoshi, Inada Toshiya, Ozaki Norio, Iwata Nakao

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 147B ( 7 ) page： 1327-1331 2008.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30781

Web of Science
Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia Reviewed

Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kitajima Tsuyoshi, Yoshimura Reiji, Hashimoto Shuji, O'Donovan Michael C., Nakamura Jun, Ozaki Norio, Iwata Nakao

PHARMACOGENOMICS Vol. 9 ( 10 ) page： 1437-1443 2008.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.2217/14622416.9.10.1437

Web of Science
Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (CHRNA4 and CHRNB2) with schizophrenia in the Japanese population Reviewed

Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Inada Toshiya, Ozaki Norio, Iwata Nakao

JOURNAL OF NEURAL TRANSMISSION Vol. 115 ( 10 ) page： 1457-1461 2008.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00702-008-0114-8

Web of Science
Plasma amitriptyline level after acute administration, and driving performance in healthy volunteers Reviewed

Iwamoto Kunihiro, Kawamura Yukiko, Takahashi Masahiro, Uchiyama Yuji, Ebe Kazutoshi, Yoshida Keizo, Iidaka Tetsuya, Noda Yukihiro, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 62 ( 5 ) page： 610-616 2008.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1440-1819.2008.01838.x

Web of Science
Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia Reviewed

Ishiguro Hiroki, Imai Keiko, Koga Minori, Horiuchi Yasue, Inada Toshiya, Iwata Nakao, Ozaki Norio, Ujike Hiroshi, Itokawa Masanari, Kunugi Hiroshi, Sasaki Tsukasa, Watanabe Yuichiro, Someya Toshiyuki, Arinami Tadao

PSYCHIATRIC GENETICS Vol. 18 ( 5 ) page： 255-256 2008.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/YPG.0b013e328306c7dc

Web of Science
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders Reviewed

Yamasaki, Nobuyuki; Maekawa, Motoko; Kobayashi, Katsunori; Kajii, Yasushi; Maeda, Jun; Soma, Miho; Takao, Keizo; Tanda, Koichi; Ohira, Koji; Toyama, Keiko; Kanzaki, Kouji; Fukunaga, Kohji; Sudo, Yusuke; Ichinose, Hiroshi; Ikeda, Masashi; Iwata, Nakao; Ozaki, Norio; Suzuki, Hidenori; Higuchi, Makoto; Suhara, Tetsuya; Yuasa, Shigeki; Miyakawa, Tsuyoshi

MOLECULAR BRAIN Vol. 1 page： 6 2008.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/1756-6606-1-6

Web of Science
No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population Reviewed

Aleksic Branko, Ikeda Masashi, Ishihara Ryoko, Saito Shinichi, Inada Toshiya, Iwata Nakao, Ozaki Norio

JOURNAL OF HUMAN GENETICS Vol. 53 ( 9 ) page： 863-866 2008.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s10038-008-0318-7

Web of Science
The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population Reviewed

Kishimoto Makiko, Ujike Hiroshi, Okahisa Yuko, Kotaka Tatsuya, Takaki Manabu, Kodama Masafumi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Kuroda Shigetoshi

BEHAVIORAL AND BRAIN FUNCTIONS Vol. 4 2008.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/1744-9081-4-37

Web of Science
Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia Reviewed

Deng Xiangdong, Sagata Noriaki, Takeuchi Naoko, Tanaka Masami, Ninomiya Hideaki, Iwata Nakao, Ozaki Norio, Shibata Hiroki, Fukumaki Yasuyuki

BMC PSYCHIATRY Vol. 8 2008.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/1471-244X-8-58

Web of Science
Up-regulation of ADM and SEPX1 in the lymphoblastoid cells of patients in monozygotic twins discordant for schizophrenia Reviewed

Kakiuchi Chihiro, Ishiwata Mizuho, Nanko Shinichiro, Ozaki Norio, Iwata Nakao, Umekage Tadashi, Tochigi Mamoru, Kohda Kazuhisa, Sasaki Tsukasa, Imamura Akira, Okazaki Yuji, Kato Tadafumi

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 147B ( 5 ) page： 557-564 2008.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30643

Web of Science
The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures Reviewed

Takahashi Tsutomu, Suzuki Michio, Tsunoda Masahiko, Kawamura Yukiko, Takahashi Nagahide, Maeno Nobuhisa, Kawasaki Yasuhiro, Zhou Shi-Yu, Hagino Hirofumi, Niu Lisha, Tsuneki Hiroshi, Kobayashi Soushi, Sasaoka Toshiyasu, Seto Hikaru, Kurachi Masayoshi, Ozaki Norio

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Vol. 32 ( 5 ) page： 1236-1242 2008.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pnpbp.2008.03.014

Web of Science
The effects of acute treatment with paroxetine, amitriptyline, and placebo on driving performance and cognitive function in healthy Japanese subjects: A double-blind crossover trial Reviewed

Iwamoto Kunihiro, Takahashi Masahiro, Nakamura Yukako, Kawamura Yukiko, Ishihara Ryoko, Uchiyama Yuji, Ebe Kazutoshi, Noda Akiko, Noda Yukihiro, Yoshida Keizo, Iidaka Tetsuya, Ozaki Norio

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 23 ( 5 ) page： 399-407 2008.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.939

Web of Science
A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6) gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population Reviewed

Ito Yoshihito, Nakamura Yukako, Takahashi Nagahide, Saito Shinichi, Aleksic Branko, Iwata Nakao, Inada Toshiya, Ozaki Norio

NEUROSCIENCE LETTERS Vol. 438 ( 1 ) page： 70-75 2008.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2008.04.010

Web of Science
No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a Japanese population Reviewed

Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Suzuki Tatsuyo, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Ozaki Norio, Iwata Nakao

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 147B ( 4 ) page： 531-534 2008.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30634

Web of Science
Association of polymorphisms in the haplotype block spanning the alternatively spliced exons of the NTNG1 gene at 1p13.3 with schizophrenia in Japanese populations Reviewed

Ohtsuki T., Horiuchi Y., Koga M., Ishiguro H., Inada T., Iwata N., Ozaki N., Ujike H., Watanabe Y., Someya T., Arinami T.

NEUROSCIENCE LETTERS Vol. 435 ( 3 ) page： 194-197 2008.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2008.02.053

Web of Science
Relationship between three serotonin receptor subtypes (HTR3A, HTR2A and HTR4) and treatment-resistant schizophrenia in the Japanese population Reviewed

Ji Xiaofei, Takahashi Nagahide, Saito Shinichi, Ishihara Ryoko, Maeno Nobuhisa, Inada Toshiya, Ozaki Norio

NEUROSCIENCE LETTERS Vol. 435 ( 2 ) page： 95-98 2008.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2008.01.083

Web of Science
Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons Reviewed

Takahashi Tsutomu, Suzuki Michio, Tsunoda Masahiko, Kawamura Yukiko, Takahashi Nagahide, Tsuneki Hiroshi, Kawasaki Yasuhiro, Zhou Shi-Yu, Kobayashi Soushi, Sasaoka Toshiyasu, Seto Hikaru, Kurachi Masayoshi, Ozaki Norio

NEUROSCIENCE LETTERS Vol. 435 ( 1 ) page： 34-39 2008.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2008.02.004

Web of Science
Replication study and meta-analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case-control population Reviewed

Albalushi Talal, Horiuchi Yasue, Ishiguro Hiroki, Koga Minori, Inada Toshiya, Iwata Nakao, Ozaki Norio, Ujike Hiroshi, Watanabe Yuichiro, Someya Toshiyuki, Arinami Tadao

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 147B ( 3 ) page： 392-396 2008.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30610

Web of Science
A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia Reviewed

Ohtsuki Tsuyuka, Koga Minori, Ishiguro Hiroki, Horiuchi Yasue, Arai Makoto, Niizato Kazuhiro, Itokawa Masanari, Inada Toshiya, Iwata Nakao, Iritani Shyuji, Ozaki Norio, Kunugi Hiroshi, Ujike Hiroshi, Watanabe Yuichiro, Someya Toshiuki, Arinami Tadao

SCHIZOPHRENIA RESEARCH Vol. 101 ( 1-3 ) page： 9-16 2008.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2008.01.027

Web of Science
Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample Reviewed

Ikeda Masashi, Takahashi Nagahide, Saito Shinichi, Aleksic Branko, Watanabe Yuichiro, Nunokawa Ayako, Yamanouchi Yoshio, Kitajima Tsuyoshi, Kinoshita Yoko, Kishi Taro, Kawashima Kunihiro, Hashimoto Ryota, Ujike Hiroshi, Inada Toshiya, Someya Toshiyuki, Takeda Masatoshi, Ozaki Norio, Iwata Nakao

SCHIZOPHRENIA RESEARCH Vol. 101 ( 1-3 ) page： 1-8 2008.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2008.01.010

Web of Science
Large-scale case-control study of a functional polymorphism in the glutamate receptor, metabotropic 3 gene in patients with schizophrenia Reviewed

Nunokawa Ayako, Watanabe Yuichiro, Kitamura Hideaki, Kaneko Naoshi, Arinami Tadao, Ujike Hiroshi, Inada Toshiya, Iwata Nakao, Kunugi Hiroshi, Itokawa Masanari, Ozaki Norio, Someya Toshiyuki

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 62 ( 2 ) page： 239-240 2008.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1440-1819.2008.01762.x

Web of Science
Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia Reviewed

Inada Toshiya, Koga Minori, Ishiguro Hiroki, Horiuchi Yasue, Syu Aoi, Yoshio Takashi, Takahashi Nagahide, Ozaki Norio, Arinami Tadao

PHARMACOGENETICS AND GENOMICS Vol. 18 ( 4 ) page： 317-323 2008.4

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins Reviewed

Kuratomi G., Iwamoto K., Bundo M., Kusumi I., Kato N., Iwata N., Ozaki N., Kato T.

MOLECULAR PSYCHIATRY Vol. 13 ( 4 ) page： 429-441 2008.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/sj.mp.4002001

Web of Science
Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence Reviewed

Otani Kyohei, Ujike Hiroshi, Sakai Ayumu, Okahisa Yuko, Kotaka Tatsuya, Inada Toshiya, Harano Mutsuo, Komiyama Tokutaro, Hori Toru, Yamada Mitsuhiko, Sekine Yoshimoto, Iwata Nakao, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Kuroda Shigetoshi

NEUROSCIENCE LETTERS Vol. 434 ( 1 ) page： 88-92 2008.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2008.01.033

Web of Science
An association study of tachykinin receptor 3 gene with schizophrenia in the Japanese population Reviewed

Saito Shinichi, Takahashi Nagahide, Maeno Nobuhisa, Ito Yoshihito, Aleksic Branko, Usui Hinako, Iidaka Tetsuya, Inada Toshiya, Ozaki Norio

NEUROREPORT Vol. 19 ( 4 ) page： 471-473 2008.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea Reviewed

Tanaka Misuzu, Kobayashi Daisuke, Murakami Yuko, Ozaki Norio, Suzuki Tatsuyo, Iwata Nakao, Haraguchi Koichi, Ieiri Ichiro, Kinukawa Naoko, Hosoi Masako, Ohtani Hisakazu, Sawada Yasufumi, Mine Kazunori

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY Vol. 11 ( 2 ) page： 261-267 2008.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1017/S1461145707007985

Web of Science
Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder Reviewed

Yoshimi Akira, Takahashi Nagahide, Saito Shinichi, Ito Yoshihito, Aleksic Branko, Usui Hinako, Kawamura Yukiko, Waki Yukari, Yoshikawa Takeo, Kato Tadafumi, Iwata Nakao, Inada Toshiya, Noda Yukihiro, Ozaki Norio

SCHIZOPHRENIA RESEARCH Vol. 100 ( 1-3 ) page： 334-341 2008.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2007.10.028

Web of Science
Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val158met polymorphism on the antidepressant effect of milnacipran Reviewed

Yoshida Keizo, Higuchi Hisashi, Takahashi Hitoshi, Kamata Mitsuhiro, Sato Kazuhiro, Inoue Kazuyuki, Suzuki Toshio, Itoh Kunihiko, Ozaki Norio

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL Vol. 23 ( 2 ) page： 121-128 2008.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/hup.907

Web of Science
Genome-wide association for methamphetamine dependence Reviewed

Uhl George R., Drgon Tomas, Liu Qing-Rong, Johnson Catherine, Walther Donna, Komiyama Tokutaro, Harano Mutsuo, Sekine Yoshimoto, Inada Toshiya, Ozaki Norio, Iyo Masaomi, Iwata Nakao, Yamada Mitsuhiko, Sora Ichiro, Chen Chih-Ken, Liu Hsing-Cheng, Ujike Hiroshi, Lin Shih-Ku

ARCHIVES OF GENERAL PSYCHIATRY Vol. 65 ( 3 ) page： 345-355 2008.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association analysis of MTHFR gene in schizophrenia Reviewed

Kawamura Y., Takahashi N., Saito S., Usui H., Yoshimi A., Ito Y., Branko A., Ishihara R., Yoshida K., Iidaka T., Inada T., Iwata N., Noda Y., Ozaki N.

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 62 ( 1 ) page： S4-S5 2008.2

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association study and copy number analysis of the DARPP-32 gene in bipolar disorder Reviewed

Yoshimi A., Takahashi N., Kawamura Y., Kato T., Kaneda N., Saito S., Usui H., Ishihara R., Inada T., Yoshikawa T., Kato T., Iwata N., Noda Y., Ozaki N.

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 62 ( 1 ) page： S5-S6 2008.2

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
The dysbindin gene (DTNBP1) is associated with methamphetamine psychosis Reviewed

Kishimoto Makiko, Ujike Hiroshi, Motohashi Yasuko, Tanaka Yuji, Kahisa Yuko, Kotaka Tatsuya, Harano Mutsuo, Inada Toshiya, Yamada Mitsuhiko, Komiyama Tokutaro, Hori Toru, Sekine Yoshimoto, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Kuroda Shigetoshi

BIOLOGICAL PSYCHIATRY Vol. 63 ( 2 ) page： 191-196 2008.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.biopsych.2007.03.019

Web of Science
The Glycine Transporter 1 Gene (GLYT1) Is Associated With Methamphetamine-Use Disorder Reviewed

Morita Yukitaka, Ujike Hiroshi, Tanaka Yuji, Kishimoto Makiko, Okahisa Yuko, Kotaka Tatsuya, Harano Mutsuo, Inada Toshiya, Komiyama Tokutaro, Hori Toru, Yamada Mitsuhiko, Sekine Yoshimoto, Iwata Nakao, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Kuroda Shigetoshi

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 147B ( 1 ) page： 54-58 2008.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30565

Web of Science
A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder Reviewed

Masui Takuya, Hashimoto Ryota, Kusumi Ichiro, Suzuki Katsuji, Tanaka Teruaki, Nakagawa Shin, Suzuki Tatsuyo, Iwata Nakao, Ozaki Norio, Kato Tadalunii, Takeda Masatoshi, Kunugi Hiroshi, Koyama Tsukasa

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Vol. 32 ( 1 ) page： 204-208 2008.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pnpbp.2007.08.010

Web of Science
Alpha4 and Beta2 Subunits of Neuronal Nicotinic Acetylcholine Receptor Genes Are Not Associated with Methamphetamine-Use Disorder in the Japanese Population Reviewed

Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Inada Toshiya, Harano Mutsuo, Komiyama Tokutaro, Hori Toru, Yamada Mitsuhiko, Iyo Masaomi, Sora Ichiro, Sekine Yoshimoto, Ozaki Norio, Ujike Hiroshi, Iwata Nakao

DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES Vol. 1139 page： 70-82 2008

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1196/annals.1432.023

Web of Science
Association Study of the Calcineurin A Gamma Subunit Gene (PPP3CC) and Methamphetamine-Use Disorder in a Japanese Population A Collaborative Study by the Japanese Genetics Initiative for Drug Abuse Reviewed

Kinoshita Y., Ikeda M., Ujike H., Kitajima T., Yamanouchi Y., Aleksic B., Kishi T., Kawashima K., Ohkouchi T., Ozaki N., Inada T., Harano M., Komiyama T., Hori T., Yamada M., Sekine Y., Iyo M., Sora I., Iwata N.

DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES Vol. 1139 page： 57-62 2008

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1196/annals.1432.021

Web of Science
Comparison of sleep-disordered breathing and heart rate variability between hemodialysis and non-hemodialysis days in hemodialysis patients.

Sukegawa M, Noda A, Soga T, Adachi Y, Tsuruta Y, Ozaki N, Koike Y

Nagoya J Med Sci Vol. 70 ( 3-4 ) page： 83-8 2008

　More details

Language：English Publishing type：Research paper (scientific journal)
Gap junction, bipolar disorder and schizophrenia: Genetic association study Reviewed

Aleksic Branko, Ikeda Masashi, Ishihara Ryoko, Takahashi Nagahide, Saito Sinichi, Matsumoto Atsushi, Inada Toshiya, Idaka Tetsuya, Iwata Nakao, Ozaki Norio

NEUROSCIENCE RESEARCH Vol. 61 page： S219-S219 2008

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Glutamate Cysteine Ligase Modifier (GCLM) Subunit Gene Is Not Associated with Methamphetamine-Use Disorder or Schizophrenia in the Japanese Population Reviewed

Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Inada Toshiya, Harano Mutsuo, Komiyama Tokutaro, Horie Toru, Yamada Mitsuhiko, Iyo Masaomi, Sora Ichiro, Sekine Yoshimoto, Ozaki Norio, Ujike Hiroshi, Iwata Nakao

DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES Vol. 1139 page： 63-69 2008

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1196/annals.1432.022

Web of Science
Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder Reviewed

Yoshimi Akira, Noda Yukihiro, Yamada Kiyofumi, Ozaki Norio

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN Vol. 128 page： 88-88 2008

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Prostate Apoptosis Response 4 Gene Is Not Associated with Methamphetamine-Use Disorder in the Japanese Population Reviewed

Kishi Taro, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Inada Toshiya, Harano Mutsuo, Komiyama Tokutaro, Hori Toru, Yamada Mitsuhiko, Iyo Masaomi, Sora Ichiro, Sekine Yoshimoto, Ozaki Norio, Ujike Hiroshi, Iwata Nakao

DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES Vol. 1139 page： 83-88 2008

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1196/annals.1432.024

Web of Science
The functional roles of "shati' in the dependence on methamphetamine (METH) Reviewed

Niwa Minae, Nitta Atsumi, Mizoguchi Hiroyuki, Itoh Yasutomo, Noda Yukihiro, Nagai Taku, Ozaki Norio, Nabeshima Toshitaka

NEUROSCIENCE RESEARCH Vol. 61 page： S271-S271 2008

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population.

Ji X, Takahashi N, Branko A, Ishihara R, Nagai T, Mouri A, Saito S, Maeno N, Inada T, Ozaki N

Nagoya J Med Sci Vol. 70 ( 1-2 ) page： 11-7 2008

　More details

Language：English Publishing type：Research paper (scientific journal)
Association analysis of the Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 (PTPRZ1) Gene with Schizophrenia in Japanese Population Reviewed

Yamada Shinnosuke, Ito Yoshihito, Yoshimi Akira, Noda Yukihiro, Ozaki Norio

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN Vol. 128 page： 87-87 2008

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association Study between Casein Kinase 1 Epsilon Gene and Methamphetamine Dependence Reviewed

Kotaka T., Ujike H., Morita Y., Kishimoto M., Okahisa Y., Inada T., Harano M., Komiyama T., Hori T., Yamada M., Sekine Y., Iwata N., Iyo M., Sora I., Ozaki N., Kuroda S.

DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES Vol. 1139 page： 43-48 2008

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1196/annals.1432.025

Web of Science
Changes in brain tryptophan metabolism elicited by ageing, social environment, and psychological stress in mice Reviewed

Miura Hideki, Ozaki Norio, Shirokawa Tetsuya, Isobe Kenichi

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS Vol. 11 ( 2 ) page： 160-169 2008

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1080/10253890701685908

Web of Science
The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats Reviewed

Nakayama Hironao, Kitaichi Kiyoyuki, Ito Yukiko, Hashimotoa Katsunori, Takagi Kenji, Yokoi Toyoharu, Takagi Kenzo, Ozaki Norio, Yamamoto Tuneyuki, Hasegawa Takaaki

BRAIN RESEARCH Vol. 1184 page： 260-269 2007.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.brainres.2007.09.072

Web of Science
Age of onset has limited association with body mass index at time of presentation for anorexia nervosa: Comparison of peak-onset and late-onset anorexia nervosa groups Reviewed

Kimura Hiroyuki, Tonoike Takashi, Muroya Tamio, Yoshida Keizo, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 61 ( 6 ) page： 646-650 2007.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1440-1819.2007.01719.x

Web of Science
Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia Reviewed

Hashimoto R., Hashimoto H., Shintani N., Chiba S., Hattori S., Okada T., Nakajima M., Tanaka K., Kawagishi N., Nemoto K., Mori T., Ohnishi T., Noguchi H., Hori H., Suzuki T., Iwata N., Ozaki N., Nakabayashi T., Saitoh O., Kosuga A., Tatsumi M., Kamijima K., Weinberger D. R., Kunugi H., Baba A.

MOLECULAR PSYCHIATRY Vol. 12 ( 11 ) page： 1026-1032 2007.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/sj.mp.4001982

Web of Science
Support for association of the PPP3CC gene with schizophrenia Reviewed

Horiuchi Y., Ishiguro H., Koga M., Inada T., Iwata N., Ozaki N., Ujike H., Muratake T., Someya T., Arinami T.

MOLECULAR PSYCHIATRY Vol. 12 ( 10 ) page： 891-893 2007.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/sj.mp.4002019

Web of Science
The new GRID Hamilton Rating Scale for depression demonstrates excellent inter-rater reliability for inexperienced and experienced raters before and after training Reviewed

Tabuse Hideaki, Kalali Amir, Azuma Hideki, Ozaki Norio, Iwata Nakao, Naitoh Hiroshi, Higuchi Teruhiko, Kanba Shigenobu, Shioe Kunihiko, Akechi Tatsuo, Furukawa Toshi A.

PSYCHIATRY RESEARCH Vol. 153 ( 1 ) page： 61-67 2007.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.psychres.2006.07.004

Web of Science
Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice Reviewed

Miura Hideki, Kitagami Tomitsune, Ozaki Norio

SYNAPSE Vol. 61 ( 9 ) page： 698-706 2007.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/syn.20407

Web of Science
Gene variants of dopamine receptors as predictors of response to risperidone treatment in first-episode schizophrenia patients Reviewed

Yamanouchi Yoshio, Ikeda Masashi, Yoshimura Reiji, Hashimoto Shuji, Nakamura Jun, Ozaki Norio, Iwata Nakao

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY Vol. 22 ( 5 ) page： A3-A3 2007.9

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription Reviewed

Ohnishi Tetsuo, Yamada Kazuo, Ohba Hisako, Iwayama Yoshimi, Toyota Tomoko, Hattori Eiji, Inada Toshiya, Kunugi Hiroshi, Tatsumi Masahiko, Ozaki Norio, Iwata Nakao, Sakamoto Kaoru, Iijima Yoshimi, Iwata Yasuhide, Tsuchiya Kenji J., Sugihara Genichi, Nanko Shinichiro, Osumi Noriko, Detera-Wadleigh Sevilla D., Kato Tadafumi, Yoshikawa Takeo

NEUROPSYCHOPHARMACOLOGY Vol. 32 ( 8 ) page： 1727-1737 2007.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/sj.npp.1301307

Web of Science
Association of SOX10 with schizophrenia in the Japanese population Reviewed

Maeno Nobuhisa, Takahashi Nagahide, Saito Shinichi, Ji Xiaofei, Ishihara Ryoko, Aoyama Nagisa, Branko Aleksic, Miura Hideki, Ikeda Masashi, Suzuki Tatsuyo, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Iwata Nakao, Inada Toshiya, Ozaki Norio

PSYCHIATRIC GENETICS Vol. 17 ( 4 ) page： 227-231 2007.8

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
The G196A polymorphism of the brain-derived neurotrophic factor gene and the antidepressant effect of milnacipran and fluvoxamine Reviewed

Yoshida Keizo, Higuchi Hisashi, Kamata Mitsuhiro, Takahashi Hitoshi, Inoue Kazuyuki, Suzuki Toshio, Roh Kunihiko, Ozaki Norio

JOURNAL OF PSYCHOPHARMACOLOGY Vol. 21 ( 6 ) page： 650-656 2007.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1177/0269881106072192

Web of Science
P2X(3) receptor mediates heat hyperalgesia in a rat model of trigeminal neuropathic pain Reviewed

Shinoda Masamichl, Kawashima Kiyohito, Ozaki Noriyuki, Asai Hideaki, Nagamine Kenjiro, Sugiura Yasuo

JOURNAL OF PAIN Vol. 8 ( 7 ) page： 588-597 2007.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jpain.2007.03.001

Web of Science
Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis Reviewed

Matsuzawa Daisuke, Hashimoto Kenji, Miyatake Ryosuke, Shirayama Yukihiko, Shimizu Eiji, Maeda Kazuhisa, Suzuki Yoichi, Mashimo Yoichi, Sekine Yoshimoto, Inada Toshiya, Ozaki Norio, Iwata Nakao, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Sora Ichiro, Ujike Hiroshi, Hata Akira, Sawa Akira, Iyo Masaomi

AMERICAN JOURNAL OF PSYCHIATRY Vol. 164 ( 7 ) page： 1105-1114 2007.7

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
The aggressive behavior of autistic patients. Some general considerations Reviewed

Muraru Oana, Honjo Shuji, Murase Satomi, Kaneko Hitoshi, Nomura Kenji, Ishii Takashi, Koishi Seiji, Ishikawa Naoko, Ozaki Norio

ROMANIAN JOURNAL OF LEGAL MEDICINE Vol. 15 ( 2 ) page： 127-134 2007.6

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Gap junction coding genes and schizophrenia: a genetic association study Reviewed

Aleksic Branko, Ishihara Ryoko, Takahashi Nagahide, Maeno Nobuhisa, Ji Xiaofei, Saito Shinichi, Inada Toshiya, Ozaki Norio

JOURNAL OF HUMAN GENETICS Vol. 52 ( 6 ) page： 498-501 2007.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s10038-007-0142-5

Web of Science
PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: Association study in a large case-control population Reviewed

Ishiguro H., Koga M., Horiuchi Y., Inada T., Iwata N., Ozaki N., Ujike H., Muratake T., Someya T., Arinami T.

NEUROSCIENCE RESEARCH Vol. 58 ( 2 ) page： 145-148 2007.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neures.2007.02.008

Web of Science
Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population Reviewed

Koga Minori, Ishiguro Hiroki, Horiuchi Yasue, Albalushi Talal, Inada Toshiya, Iwata Nakao, Ozaki Norio, Ujike Hiroshi, Muratake Tatsuyuki, Someya Toshiyuki, Arinami Tadao

NEUROSCIENCE LETTERS Vol. 417 ( 3 ) page： 326-329 2007.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2007.02.055

Web of Science
No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population Reviewed

Ikeda Masashi, Ozaki Norio, Yamanouchi Yoshio, Suzuki Tatsuyo, Kitajima Tsuyoshi, Kinoshita Yoko, Inada Toshiya, Iwata Nakao

BIOLOGICAL PSYCHIATRY Vol. 61 ( 8 ) page： 206S-207S 2007.4

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia Reviewed

Deng Xiangdong, Shibata Hiroki, Takeuchi Naoko, Rachi Shinako, Sakai Mayumi, Ninomiya Hideaki, Iwata Nakao, Ozaki Norio, Fukumaki Yasuyuki

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 144B ( 3 ) page： 271-278 2007.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30351

Web of Science
Characterization of seizure-prone phenotype in Pten mutant mice Reviewed

Ogawa S., Kwon C. H., Parada L. F., Ozaki N., Sinton C. M.

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 61 ( 2 ) page： S9-S9 2007.4

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association study between Apolipoprotein L and schizophrenia by exhaustive and rule-based combination analysis for identification of multilocus interactions Reviewed

Tomita Yasuyuki, Ikeda Masashi, Mutoh Hironori, Inada Toshiya, Iwata Nakao, Ozaki Norio, Honda Hiroyuki

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 103 ( 4 ) page： 303-310 2007.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1263/jbb.103.303

Web of Science
Association study between the transferrin gene and schizophrenia in the Japanese population Reviewed

Maeno Nobuhisa, Takahashi Nagahide, Saito Shinichi, Ji Xiaofei, Branko Aleksic, Ishihara Ryoko, Yoshida Keizo, Inada Toshiya, Iidaka Tetsuya, Ozaki Norio

NEUROREPORT Vol. 18 ( 5 ) page： 517-520 2007.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Gene-gene interaction analysis of personality traits in a Japanese population using an electrochemical DNA array chip analysis Reviewed

Urata Tomohiro, Takahashi Nagahide, Hakamata Yuko, Iijima Yoshimi, Kuwahara Natsurni, Ozaki Norio, Ono Yutaka, Amano Masahiko, Inada Toshiya

NEUROSCIENCE LETTERS Vol. 414 ( 3 ) page： 209-212 2007.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2006.12.018

Web of Science
No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population Reviewed

Ikeda Masashi, Ozaki Norio, Yamanouchi Yoshio, Suzuki Tatsuyo, Kitajima Tsuyoshi, Kinoshita Yoko, Inada Toshiya, Iwata Nakao

SCHIZOPHRENIA RESEARCH Vol. 91 ( 1-3 ) page： 22-26 2007.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2006.12.020

Web of Science
Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia Reviewed

Ikeda M., Ozaki N., Suzuki T., Kitajima T., Yamanouchi Y., Kinoshita Y., Kishi T., Sekine Y., Iyo M., Harano M., Komiyama T., Yamada M., Sora I., Ujike H., Inada T., Iwata N.

GENES BRAIN AND BEHAVIOR Vol. 6 ( 1 ) page： 107-112 2007.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1601-183X.2006.00237.x

Web of Science
RGS4 is not a susceptibility gene for schizophrenia in Japanese: Association study in a large case-control population Reviewed

Ishiguro H., Horiuchi Y., Koga M., Inada T., Iwata N., Ozaki N., Ujike H., Muratake T., Someya T., Arinami T.

SCHIZOPHRENIA RESEARCH Vol. 89 ( 1-3 ) page： 161-164 2007.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2006.09.015

Web of Science
Successful treatment of trigeminal neuralgia with milnacipran Reviewed

Ito Mikiko, Yoshida Keizo, Kimura Hiroyuki, Ozaki Norio, Kurita Kenichi

CLINICAL NEUROPHARMACOLOGY Vol. 30 ( 3 ) page： 183-185 2007

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/WNF.0B013E31803BB3DA

Web of Science
Identification of YWHAE, a gene encoding 14-3-3 epsilon, as a novel susceptibility gene for schizophrenia Reviewed

Hikita Takao, Ikeda Masashi, Taya Shinichiro, Miyakawa Takeshi, Kaibuchi Kozo, Ozaki Norio, Iwata Nakao

NEUROSCIENCE RESEARCH Vol. 58 page： S65-S65 2007

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Successful treatment of severe antidepressant-induced nausea with a combination of milnacipran and olanzapine

Ozaki Norio

Pharmacopsychiatry Vol. 40 ( 2 ) page： 84-5 2007

　More details

Language：English Publishing type：Research paper (scientific journal)
Volume of left amygdala subregion predicted temperamental trait of harm avoidance in female young subjects. A voxel-based morphometry study Reviewed

Iidaka Tetsuya, Matsumoto Atsushi, Ozaki Norio, Suzuki Tatsuyo, Iwata Nakao, Yamamoto Yukiko, Okada Tomohisa, Sadato Norihiro

BRAIN RESEARCH Vol. 1125 page： 85-93 2006.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.brainres.2006.09.015

Web of Science
Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa Reviewed

Ando Tetsuya, Komaki Gen, Naruo Tetsuro, Okabe Kenjiro, Takii Masato, Kawai Keisuke, Konjiki Fujiko, Takei Michiko, Oka Takakazu, Takeuchi Kaori, Masuda Akinori, Ozaki Norio, Suematsu Hiroyuki, Denda Kenzo, Kurokawa Nobuo, Itakura Kotarou, Yamaguchi Chikara, Kono Masaki, Suzuki Tatsuyo, Nakai Yoshikatsu, Nishizono-Maher Aya, Koide Masanori, Murakami Ken, Nagamine Kiyohide, Tomita Yuichiro, Ookuma Kazuyoshi, Tomita Kazutni, Tonai Eita, Ooshima Akira, Ishikawa Toshio, Ichimaru Yuhei

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 141B ( 8 ) page： 929-934 2006.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30387

Web of Science
The 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population Reviewed

Usui Hinako, Takahashi Nagahide, Saito Shinichi, Ishihara Ryoko, Aoyama Nagisa, Ikeda Masashi, Suzuki Tatsuyo, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Yoshida Keizo, Iwata Nakao, Inada Toshiya, Ozaki Norio

SCHIZOPHRENIA RESEARCH Vol. 88 ( 1-3 ) page： 245-250 2006.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2006.07.019

Web of Science
Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling Reviewed

Hashimoto Ryota, Numakawa Tadahiro, Ohnishi Takashi, Kumamaru Emi, Yagasaki Yuki, Ishimoto Tetsuya, Mori Takeyuki, Nemoto Kiyotaka, Adachi Naoki, Izumi Aiko, Chiba Sachie, Noguchi Hiroko, Suzuki Tatsuyo, Iwata Nakao, Ozaki Norio, Taguchi Takahisa, Kamiya Atsushi, Kosuga Asako, Tatsumi Masahiko, Kamijima Kunitoshi, Weinberger Daniel R., Sawa Akira, Kunugi Hiroshi

HUMAN MOLECULAR GENETICS Vol. 15 ( 20 ) page： 3024-3033 2006.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/hmg/ddl244

Web of Science
VAMP2 gene polymorphisms and fluvoxamine response in Japanese depressive patients Reviewed

Saito Shinichi, Takahashi Nagahide, Ishihara Ryoko, Ikeda Masashi, Suzuki Tatsuyo, Kitajima Tsuyoshi, Yamanouchi Yoshio, Iwata Nakao, Yamada Mitsuhiko, Yoshida Keizo, Inada Toshiya, Ozaki Norio

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 141B ( 7 ) page： 788-788 2006.10

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Psychiatric intervention for patients with co-occurrence of heart failure and depression Reviewed

Ozaki Norio

JOURNAL OF CARDIAC FAILURE Vol. 12 ( 8 ) page： S151-S151 2006.10

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder Reviewed

Aoyama Nagisa, Takahashi Nagahide, Kitaichi Kiyoyuki, Ishihara Ryoko, Saito Shinichi, Maeno Nobuhisa, Ji Xiaofei, Takagi Kenji, Sekine Yoshimoto, Iyo Masaomi, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Sora Ichiro, Ujike Hiroshi, Iwata Nakao, Inada Toshiya, Ozaki Norio

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Vol. 30 ( 10 ) page： 1644-1649 2006.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1530-0277.2006.00215.x

Web of Science
Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations Reviewed

Nakamura Kazuhiko, Chen Chih-Ken, Sekine Yoshimoto, Iwata Yasuhide, Anitha A., Loh El-Wui, Takei Nori, Suzuki Atsuko, Kawai Masayoshi, Takebayashi Kiyokazu, Suzuki Katsuaki, Minabe Yoshio, Tsuchiya Kenji, Yamada Kazuo, Iyo Masaomi, Ozaki Norio, Inada Toshiya, Iwata Nakao, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Sora Ichiro, Ujike Hiroshi, Ball David M., Yoshikawa Takeo, Lin Shih-Ku, Mori Norio

HUMAN GENETICS Vol. 120 ( 2 ) page： 243-252 2006.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00439-006-0189-y

Web of Science
An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder Reviewed

Suzuki Atsuko, Nakamura Kazuhiko, Sekine Yoshimoto, Minabe Yoshio, Takei Nori, Suzuki Katsuaki, Iwata Yasuhide, Kawai Masayoshi, Takebayashi Kiyokazu, Matsuzaki Hideo, Iyo Masaomi, Ozaki Norio, Inada Tosihiya, Iwata Nakao, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Sora Ichiro, Ujike Hiroshi, Mori Norio

PSYCHIATRIC GENETICS Vol. 16 ( 4 ) page： 133-138 2006.8

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Diagnosis and treatment of depression in dialysis patients Reviewed

Kimura Hiroyuki, Ozaki Norio

THERAPEUTIC APHERESIS AND DIALYSIS Vol. 10 ( 4 ) page： 328-332 2006.8

　More details

Language：English

Web of Science
Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis Reviewed

Kobayashi Hideaki, Hata Harumi, Ujike Hiroshi, Harano Mutsuo, Inada Toshiya, Komiyama Tokutaro, Yamada Mitsuhiko, Sekine Yoshimoto, Iwata Nakao, Iyo Masaomi, Ozaki Norio, Itokawa Masanari, Naka Maki, Ide Soichiro, Ikeda Kazutaka, Numachi Yohtaro, Sora Ichiro

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 141B ( 5 ) page： 482-486 2006.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30337

Web of Science
Vesicle-associated membrane protein 2 (VAMP2) gene polymorphism and fluvoxamine response Reviewed

Saito S., Takahashi N., Maeno N., Ji Xiaofei, Aoyama N., Ishihara R., Ikeda M., Yamanouchi Y., Kitajima T., Suzuki T., Yamada M., Iwata N., Inada T., Ozaki N.

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY Vol. 21 ( 4 ) page： A12-A13 2006.7

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association study between cytochrome P450 2D6 genotype and patients with methamphetamine dependence Reviewed

Otani Kyohei, Ujike Hiroshi, Sakai Ayumu, Tanaka Yuji, Uchida Naohiko, Nomura Akira, Morita Yukitaka, Kishimoto Makiko, Morio Akiko, Inada Toshiya, Harano Mutsuo, Komiyama Tokutaro, Hori Toru, Yamada Mitsuhiko, Sekine Yoshimoto, Iwata Nakao, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Kuroda Shigetoshi

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY Vol. 21 ( 4 ) page： A31-A32 2006.7

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder Reviewed

Aoyama Nagisa, Kitaichi Kiyoyuki, Takahashi Nagahide, Saito Shinichi, Maemo Nobuhisa, Iwata Nakao, Ujike Hiroshi, Harano Mutsuo, Sora Ichiro, Iyo Masaomi, Komiyama Tokutaro, Yamada Mitsuhiko, Sekine Yoshimoto, Inada Toshiya, Ozaki Norio

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY Vol. 21 ( 4 ) page： A32-A32 2006.7

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
No association of serotonin transporter gene (SLC6A4) with schizophrenia and bipolar disorder in Japanese patients: association analysis based on linkage disequilibrium Reviewed

Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N

JOURNAL OF NEURAL TRANSMISSION Vol. 113 ( 7 ) page： 899-905 2006.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00702-005-0349-6

Web of Science
The relationship between the polymorphism in the 5-HT3B receptor gene and nausea induced by paroxetine in Japanese patients Reviewed

Tanaka Misuzu, Kobayashi Daisuke, Murakami Yuko, Suzuki Tatsuyo, Iwata Nakao, Ozaki Norio, Haraguchi Koichi, Ieiri Ichiro, Hosoi Masako, Sawada Yasufumi, Kubo Chiharu, Mine Kazunori

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY Vol. 21 ( 4 ) page： A12-A12 2006.7

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population Reviewed

Aoyama N, Takahashi N, Saito S, Maeno N, Ishihara R, Ji X, Miura H, Yamanouchi Y, Kinoshita Y, Yoshida K, Iwata N, Inada T, Ozaki N

GENES BRAIN AND BEHAVIOR Vol. 5 ( 4 ) page： 364-368 2006.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1601-183X.2006.00231.x

Web of Science
Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence Reviewed

Nomura Akira, Ujike Hiroshi, Tanaka Yuji, Otani Kyohei, Morita Yukitaka, Kishimoto Makiko, Morio Akiko, Harano Mutsuo, Inada Toshiya, Yamada Mitsuhiko, Komiyama Tokutaro, Sekine Yoshimoto, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Kuroda Shigetoshi

NEUROSCIENCE LETTERS Vol. 400 ( 1-2 ) page： 158-162 2006.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2006.02.038

Web of Science
Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms Reviewed

Ide S., Kobayashi H., Ujike H., Ozaki N., Sekine Y., Inada T., Harano M., Komiyama T., Yamada M., Iyo M., Iwata N., Tanaka K., Shen H., Iwahashi K., Itokawa M., Minami M., Satoh M., Ikeda K., Sora I.

PHARMACOGENOMICS JOURNAL Vol. 6 ( 3 ) page： 179-188 2006.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/sj.tpj.6500355

Web of Science
An association study of bipolar disorder with chromogranin B gene Reviewed

Iljima Y, Inada T, Kunugi H, Okada T, Sakamoto K, Fukunaga T, Arinami T, Ohtsuki T, Yoshikawa T, Yamada K, Ozaki N, Iwata N, Kato T, Tatsumi M, Nanko S

BIOLOGICAL PSYCHIATRY Vol. 59 ( 8 ) page： 209S-209S 2006.4

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association between OLIG2 gene polymorphismand schizophrenia in the Japanese population Reviewed

Takahashi N, Usui H, Saito S, Maemo N, Ishihara R, Aoyama N, Ji XF, Miura H, Yoshida K, Inada T, Ozaki N

BIOLOGICAL PSYCHIATRY Vol. 59 ( 8 ) page： 129S-130S 2006.4

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population Reviewed

Ikeda M, Iwata N, Kitajima T, Suzuki T, Yamanouchi Y, Kinoshita Y, Ozaki N

NEUROPSYCHOPHARMACOLOGY Vol. 31 ( 4 ) page： 866-871 2006.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/sj.npp.1300901

Web of Science
Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population Reviewed

Takahashi N, Ishihara R, Saito S, Maemo N, Aoyama N, Ji XF, Miura H, Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N, Inada T

SCHIZOPHRENIA RESEARCH Vol. 83 ( 2-3 ) page： 179-183 2006.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2005.12.854

Web of Science
Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder Reviewed

Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Kunugi H, Koyama T

PSYCHIATRIC GENETICS Vol. 16 ( 2 ) page： 49-50 2006.4

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Regional brain cerebral glucose metabolism and temperament: A positron emission tomography study Reviewed

Hakamata Y, Iwase M, Iwata H, Kobayashi T, Tamaki T, Nishio M, Kawahara K, Matsuda H, Ozaki N, Honjo S, Inada T

NEUROSCIENCE LETTERS Vol. 396 ( 1 ) page： 33-37 2006.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2005.11.017

Web of Science
No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population Reviewed

Kishi T, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N, Iwata N

SCHIZOPHRENIA RESEARCH Vol. 82 ( 2-3 ) page： 185-189 2006.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2005.12.842

Web of Science
Positive association of AKT1 haplotype to Japanese methamphetamine use disorder Reviewed

Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshiya Y, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada T, Ozaki N

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY Vol. 9 ( 1 ) page： 77-81 2006.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1017/S1461145705005481

Web of Science
Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GPJK5) with schizophrenia Reviewed

Shibata H, Aramaki T, Sakai M, Ninomiya H, Tashiro N, Iwata N, Ozaki N, Fukumaki Y

PSYCHIATRY RESEARCH Vol. 141 ( 1 ) page： 39-51 2006.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.psychres.2005.07.015

Web of Science
The influence of insufficient sleep on cerebral blood volume Reviewed

Miyata S., Noda A., Adachi Y., Okuda M., Hara Y., Minoshima M., Sukegawa M., Iidaka T., Ozaki N., Koike Y.

SLEEP Vol. 29 page： A116-A116 2006

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association study between vesicle-associated membrane protein 2 gene polymorphisms and fluvoxamine response in Japanese major depressive patients Reviewed

Saito Shinichi, Takahashi Nagahide, Ishihara Ryoko, Ikeda Masashi, Suzuki Tatsuyo, Kitajima Tsuyoshi, Yamanouchi Yoshio, Iwata Nakao, Yamada Mitsuhiko, Yoshida Keizo, Inada Toshiya, Ozaki Norio

NEUROPSYCHOBIOLOGY Vol. 54 ( 4 ) page： 226-230 2006

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1159/000100777

Web of Science
Association study of the tumor necrosis factor-alpha gene and its 1A receptor gene with methamphetamine dependence Reviewed

Nomura A., Ujike H., Tanaka Y., Kishimoto M., Otani K., Morita Y., Morio A., Harano M., Inada T., Yamada M., Komiyama T., Hori T., Sekine Y., Iwata N., Sora I., Iyo M., Ozaki N., Kuroda S.

CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY: COCAINE, GHB, AND SUBSTITUTED AMPHETAMINES Vol. 1074 page： 116-124 2006

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1196/annals.1369.011

Web of Science
Association study of the dihydropyrimidinase-related protein 2 gene and methamphetamine psychosis Reviewed

Ujike H., Sakai A., Nakata K., Tanaka Y., Kodaka T., Okahisa Y., Harano M., Inada T., Yamada M., Komiyama T., Hori T., Sekine Y., Iwata N., Sora I., Iyo M., Ozaki N., Kuroda S.

CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY: COCAINE, GHB, AND SUBSTITUTED AMPHETAMINES Vol. 1074 page： 90-96 2006

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1196/annals.1369.008

Web of Science
Disability and patient's appraisal of general health contribute to depressed mood in rheumatoid arthritis in a large clinical study in Japan

Ozaki Norio

Mod Rheumatol Vol. 16 ( 3 ) page： 151-7 2006

　More details

Language：English Publishing type：Research paper (scientific journal)
Factors contributing to sleep disturbance and hypnotic drug use in hemodialysis patients Reviewed

Noda Akiko, Nakai Shigeru, Soga Taro, Sugiura Tatsuki, Iwayama Norihisa, Maeda Kenji, Atarashi Misaho, Yasuma Fumihiko, Ozaki Norio, Yokota Mitsuhiro, Koike Yasuo

INTERNAL MEDICINE Vol. 45 ( 22 ) page： 1273-1278 2006

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.2169/internalmedicine.45.1826

Web of Science
No association between CART (cocaine- and amphetamine-regulated transcript) gene and methamphetamine dependence Reviewed

Morio A., Ujike H., Nomura A., Tanaka Y., Morita Y., Otani K., Kishimoto M., Harano M., Inada T., Komiyama T., Yamada M., Sekine Y., Iwata N., Iyo M., Sora I., Ozaki N., Kuroda S.

CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY: COCAINE, GHB, AND SUBSTITUTED AMPHETAMINES Vol. 1074 page： 411-417 2006

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1196/annals.1369.041

Web of Science
Sleeping and life habits in morning and evening types of sleep-wake rhythm Reviewed

Kato H., Noda A., Miyata S., Morishita Y., Adachi Y., Iwami A., Sukegawa M., Maeno N., Ozaki N., Koike Y.

SLEEP Vol. 29 page： A57-A57 2006

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
No association between monoamine oxidase A promoter polymorphism and personality traits in Japanese females Reviewed

Hakamata Y, Takahashi N, Ishihara R, Saito S, Ozaki N, Honjo S, Ono Y, Inada T

NEUROSCIENCE LETTERS Vol. 389 ( 3 ) page： 121-123 2005.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2005.03.075

Web of Science
Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p Reviewed

Arinami T, Arinami T, Ohtsuki T, Ishiguro H, Ujike H, Tanaka Y, Morita Y, Mineta M, Takeichi M, Yamada S, Imamura A, Ohara K, Shibuya H, Ohara K, Suzuki Y, Muratake T, Kaneko N, Someya T, Inada T, Yoshikawa T, Toyota T, Yamada K, Kojima T, Takahashi S, Osamu O, Shinkai T, Nakamura M, Fukuzako H, Hashiguchi T, Niwa S, Ueno T, Tachikawa H, Hori T, Asada T, Nanko S, Kunugi H, Hashimoto R, Ozaki N, Iwata N, Harano M, Arai H, Ohnuma T, Kusumi I, Koyama T, Yoneda H, Fukumaki Y, Shibata H, Kaneko S, Higuchi H, Yasui-Furukori N, Numachi Y, Itokawa M, Okazaki Y

AMERICAN JOURNAL OF HUMAN GENETICS Vol. 77 ( 6 ) page： 937-944 2005.12

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients Reviewed

Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T, Ozaki N

SCHIZOPHRENIA RESEARCH Vol. 78 ( 2-3 ) page： 127-130 2005.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2005.05.002

Web of Science
Cross-cultural equivalence in depression assessment: Japan-Europe-North American study Reviewed

Furukawa TA, Streiner DL, Azuma H, Higuchi T, Kamijima K, Kanba S, Ozaki N, Aoba A, Murasaki M, Miura S

ACTA PSYCHIATRICA SCANDINAVICA Vol. 112 ( 4 ) page： 279-285 2005.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1600-0447.2005.00587.x

Web of Science
Association analysis of chromosome 5 GABA(A) receptor cluster in Japanese schizophrenia patients Reviewed

Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T, Ujike H, Ozaki N

BIOLOGICAL PSYCHIATRY Vol. 58 ( 6 ) page： 440-445 2005.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.biopsych.2005.05.002

Web of Science
Significant association between chromogranin a gene polymorphism and schizophrenia in the Japanese population Reviewed

Takahashi N, Ishihara R, Saito S, Maemo N, Aoyama N, Ji X, Miura H, Ozaki N, Inada T

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 138B ( 1 ) page： 136-137 2005.9

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients Reviewed

Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T, Ozaki N

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 138B ( 1 ) page： 48-49 2005.9

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
No association with the calcineurin A gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia Reviewed

Kinoshita Y, Suzuki T, Ikeda M, Kitajima T, Yamanouchi Y, Inada T, Yoneda H, Iwata N, Ozaki N

JOURNAL OF NEURAL TRANSMISSION Vol. 112 ( 9 ) page： 1255-1262 2005.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00702-004-0261-5

Web of Science
Heat and mechanical hyperalgesia in mice model of cancer pain Reviewed

Asai H, Ozaki N, Shinoda M, Nagamine K, Tohnai I, Ueda M, Sugiura Y

PAIN Vol. 117 ( 1-2 ) page： 19-29 2005.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.pain.2005.05.010

Web of Science
The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence Reviewed

Morita Y, Ujike H, Tanaka Y, Uchida N, Nomura A, Otani K, Kishimoto M, Morio A, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N

NEUROSCIENCE LETTERS Vol. 383 ( 1-2 ) page： 194-198 2005.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2005.04.014

Web of Science
A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala Reviewed

Iidaka T, Ozaki N, Matsumoto A, Nogawa J, Kinoshita Y, Suzuki T, Iwata N, Yamamoto Y, Okada T, Sadato N

JOURNAL OF NEUROSCIENCE Vol. 25 ( 27 ) page： 6460-6466 2005.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1523/JNEUROSCI.5261-04.2005

Web of Science
Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis Reviewed

Ohgake S, Hashimoto K, Shimizu E, Koizumi H, Okamura N, Koike K, Matsuzawa D, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Shirayama Y, Iyo M

ADDICTION BIOLOGY Vol. 10 ( 2 ) page： 145-148 2005.6

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1080/13556210500123423

Web of Science
A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population Reviewed

Hashimoto T, Hashimoto K, Matsuzawa D, Shimizu E, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iyo M

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 135B ( 1 ) page： 5-9 2005.5

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30164

Web of Science
Studies on the adverse effects of paroxetine in Japanese patients: correlation with genetic polymorphisms in CYP2D6 and serotonin related genes Reviewed

Murakami Y, Kobayashi D, Suzuki T, Iwata N, Ozaki N, Haraguchi K, Ieiri I, Hosoi M, Sawada Y, Kubo C, Mine K

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY Vol. 20 ( 3 ) page： A9-A9 2005.5

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Changes in the plasma chromogranin levels in patients with schizophrenia Reviewed

Takahashi N, Inada T, Ishihara R, Miura H, Saito S, Maeno N, Kurei S, Okamoto E, Ozaki N

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY Vol. 20 ( 3 ) page： A11-A11 2005.5

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
No association of GSK3 beta gene (GSK3B) with Japanese schizophrenia Reviewed

Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Ozaki N

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 134B ( 1 ) page： 90-92 2005.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30155

Web of Science
Personality of seasonal affective disorder analyzed by Tri-dimensional Personality Questionnaire Reviewed

Maeno N, Kusunoki K, Kitajima T, Iwata N, Ono Y, Hashimoto S, Imai M, Li L, Kayukawa Y, Ohta T, Ozaki N

JOURNAL OF AFFECTIVE DISORDERS Vol. 85 ( 3 ) page： 267-273 2005.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jad.2004.10.005

Web of Science
Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia Reviewed

Hashimoto R, Numakawa T, Yagasaki Y, Ishimoto T, Okada T, Suzuki T, Iwata N, Ozaki N, Taguchi T, Tatsumi M, Kamijima K, Straub R, Weinberger D, Kunugi H

SCHIZOPHRENIA BULLETIN Vol. 31 ( 2 ) page： 268-269 2005.4

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia Reviewed

Morita Y, Ujike H, Tanaka Y, Uchida N, Nomura A, Ohtani K, Kishimoto M, Morio A, Imamura T, Sakai A, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S

NEUROSCIENCE LETTERS Vol. 376 ( 3 ) page： 182-187 2005.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.neulet.2004.11.050

Web of Science
A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men Reviewed

Hashimoto R, Yoshida M, Kunugi H, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K

SCHIZOPHRENIA RESEARCH Vol. 73 ( 2-3 ) page： 383-385 2005.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.schres.2004.01.017

Web of Science
Psychosomatic analysis of atopic dermatitis using a psychological test Reviewed

Arima M, Shimizu Y, Sowa J, Narita T, Nishi I, Iwata N, Ozaki N, Hashimoto S, Matsunaga K

JOURNAL OF DERMATOLOGY Vol. 32 ( 3 ) page： 160-168 2005.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Effects of fluvoxamine on levels of dopamine, serotonin, and their metabolites in the hippocampus elicited by isolation housing and novelty stress in adult rats Reviewed

Miura H, Qiao H, Kitagami T, Ohta T, Ozaki N

INTERNATIONAL JOURNAL OF NEUROSCIENCE Vol. 115 ( 3 ) page： 367-378 2005.3

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1080/00207450590520984

Web of Science
No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population Reviewed

Saito S, Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Takahashi N, Inada T, Ozaki N

NEUROSCIENCE LETTERS Vol. 374 ( 1 ) page： 21-24 2005.2

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders Reviewed

Hashimoto R, Suzuki T, Iwata N, Yamanouchi Y, Kitajima T, Kosuga A, Tatsumi M, Ozaki N, Kamijima K, Kunugi H

JOURNAL OF NEURAL TRANSMISSION Vol. 112 ( 2 ) page： 303-307 2005.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00702-004-0264-2

Web of Science
Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan Reviewed

Itoh K, Hashimoto K, Shimizu E, Sekine Y, Ozaki N, Inada T, Harano M, Iwata N, Komiyama T, Yamada M, Sora I, Nakata K, Ujike H, Iyo M

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 132B ( 1 ) page： 70-73 2005.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.30097

Web of Science
Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice Reviewed

Miura H, Qiao H, Kitagami T, Ohta T, Ozaki N

PSYCHOPHARMACOLOGY Vol. 177 ( 3 ) page： 307-314 2005.1

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00213-004-1959-7

Web of Science
Haplotype association between GABA(A) receptor gamma 2 subunit gene (GABRG2) and methamphetamine use disorder Reviewed

Nishiyama T, Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada T, Furukawa TA, Ozaki N

PHARMACOGENOMICS JOURNAL Vol. 5 ( 2 ) page： 89-95 2005

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/sj.tpj.6500292

Web of Science
Mitochondrial DNA 3644T -> C mutation associated with bipolar disorder Reviewed

Munakata K, Tanaka M, Mori K, Washizuka S, Yoneda M, Tajima O, Akiyama T, Nanko S, Kunugi H, Tadokoro K, Ozaki N, Inada T, Sakamoto K, Fukunaga T, Iijima Y, Iwata N, Tatsumi M, Yamada K, Yoshikawa T, Kato T

GENOMICS Vol. 84 ( 6 ) page： 1041-1050 2004.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.ygeno.2004.08.015

Web of Science
Hypersomnia, asterixis and cataplexy in association with orexin A-reduced hypothalamic tumor Reviewed

Nokura K, Kanbayashi T, Ozeki T, Koga H, Zettsu T, Yamamoto H, Ozaki N, Shimizu T, Kawase T

JOURNAL OF NEUROLOGY Vol. 251 ( 12 ) page： 1534-1535 2004.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00415-004-0575-0

Web of Science
Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia Reviewed

Numakawa T, Yagasaki Y, Ishimoto T, Okada T, Suzuki T, Iwata N, Ozaki N, Taguchi T, Tatsumi M, Kamijima K, Straub RE, Weinberger DR, Kunugi H, Hashimoto R

HUMAN MOLECULAR GENETICS Vol. 13 ( 21 ) page： 2699-2708 2004.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/hmg/ddh280

Web of Science
Association of AKT1 with schizophrenia confirmed in a Japanese population Reviewed

Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T, Ozaki N

BIOLOGICAL PSYCHIATRY Vol. 56 ( 9 ) page： 698-700 2004.11

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.biopsych.2004.07.023

Web of Science
A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders Reviewed

Takano A, Uchiyama M, Kajimura N, Mishima K, Inoue Y, Kamei Y, Kitajima T, Shibui K, Katoh M, Watanabe T, Hashimotodani Y, Nakajima T, Ozeki Y, Hori T, Yamada N, Toyoshima R, Ozaki N, Okawa M, Nagai K, Takahashi K, Isojima Y, Yamauchi T, Ebisawa T

NEUROPSYCHOPHARMACOLOGY Vol. 29 ( 10 ) page： 1901-1909 2004.10

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/sj.npp.1300503

Web of Science
Sequence variations in human casein kinase1epsilon gene and circadian rhythm sleep disorders Reviewed

Takano A, Uchiyama M, Kajimura N, Mishima K, Inoue Y, Kamei Y, Kitajima T, Shibui K, Katoh M, Watanabe T, Hashimotodani Y, Nakajima T, Ozeki Y, Hori T, Yamada N, Toyoshima R, Ozaki N, Okawa M, Nagai K, Takahashi K, Isojima Y, Yamauchi T, Ebisawa T

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 130B ( 1 ) page： 152-153 2004.9

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a Multicenter study Reviewed

Kunugi H, Iijima Y, Tatsumi M, Yoshida M, Hashimoto R, Kato T, Sakamoto K, Fukunaga T, Inada T, Suzuki T, Iwata N, Ozaki N, Yamada K, Yoshikawa T

BIOLOGICAL PSYCHIATRY Vol. 56 ( 5 ) page： 376-378 2004.9

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.biopysch.2004.06.017

Web of Science
Association between the glutathione S-transferase M1 gene deletion and female methamphetamine abusers Reviewed

Koizumi H, Hashimoto K, Kumakiri C, Shimizu E, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Takei N, Iyo M

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 126B ( 1 ) page： 43-45 2004.4

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.20148

Web of Science
No association with the neuregulin 1 haplotype to Japanese schizophrenia Reviewed

Iwata N, Suzuki T, Ikeda M, Kitajima T, Yamanouchi Y, Inada T, Ozaki N

MOLECULAR PSYCHIATRY Vol. 9 ( 2 ) page： 126-127 2004.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/sj.mp.4001456

Web of Science
Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-alpha) gene in Japanese patients with schizophrenia Reviewed

Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K, Kunugi H

JOURNAL OF NEURAL TRANSMISSION Vol. 111 ( 2 ) page： 217-221 2004.2

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00702-003-0101-z

Web of Science
A polymorphism of DRD2 gene and brain atrophy in methamphetamine psychosis Reviewed

Harano M, Uchimura N, Abe H, Ishibashi M, Iida N, Yanagimoto K, Tanaka T, Maeda H, Sora I, Iyo M, Komiyama T, Yamada M, Sekine Y, Inada T, Ozaki N, Ujike H

CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY Vol. 1025 page： 307-315 2004

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1196/annals.1316.038

Web of Science
精神科リエゾンガイドライン　心筋梗塞に伴ううつ病について

尾崎　紀夫

精神科治療学 Vol. 19 page： 205-209 2004

　More details

Language：Japanese Publishing type：Research paper (scientific journal)
遺伝子研究によってどこまで精神疾患の病態は解明されたか　薬物依存と遺伝子関連研究

尾崎　紀夫

精神神経学雑誌 Vol. 106 ( 12 ) page： 1598-1603 2004

　More details

Language：Japanese Publishing type：Research paper (scientific journal)
依存性医薬品の使い方　抗うつ薬（臨床）抗うつ薬中止症状に関して　臨床の立場から

尾崎　紀夫

日本神経精神薬理学雑誌 Vol. 24 ( 5 ) page： 311 2004

　More details

Language：Japanese Publishing type：Research paper (scientific journal)
統合失調症の神経発達障害・神経変性仮説とゲノム研究の統合

尾崎　紀夫

日本神経精神薬理学雑誌 Vol. 24 page： 211-216 2004

　More details

Language：Japanese Publishing type：Research paper (scientific journal)
遺伝と環境がうつ病において果たす役割：ゲノム医学によるうつ病克服を目指して

尾崎　紀夫

脳と精神の医学 Vol. 15 ( 1 ) page： 38-44 2004

　More details

Language：Japanese Publishing type：Research paper (scientific journal)
SSRI反応性とセロトニン(5-HT)系多型

尾崎　紀夫

分子精神医学 Vol. 4 ( 3 ) page： 205-210 2004

　More details

Language：Japanese Publishing type：Research paper (scientific journal)
インターフェロン投与中せん妄が生じた後、強迫性障害と周期的な傾眠が合併して出現した症例

尾崎　紀夫

臨床精神医学 Vol. 33 ( 1 ) page： 89-96 2004

　More details

Language：Japanese Publishing type：Research paper (scientific journal)
「こころ」と「からだ」について：精神障害と身体疾患との関係

尾崎　紀夫

現代医学 Vol. 51 ( 3 ) page： 411-417 2004

　More details

Language：Japanese Publishing type：Research paper (scientific journal)
Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia Reviewed

Deng Xiangdong, Shibata Hiroki, Ninomiya Hideaki, Tashiro Nobutada, Iwata Nakao, Ozaki Norio, Fukumaki Yasuyuki

BMC PSYCHIATRY Vol. 4 2004

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/1471-244X-4-21

Web of Science
Comparison of G-protein selectivity of human 5-HT2C and 5-HT1A receptors Reviewed

Okada M, Goldman D, Linnoila M, Iwata N, Ozaki N, Northup JK

CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY Vol. 1025 page： 570-577 2004

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1196/annals.1316.070

Web of Science
Gene polymorphisms of the Mu opioid receptor in methamphetamine abusers Reviewed

Ide S, Kobayashi H, Tanaka K, Ujike H, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Ikeda K, Sora I

CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY Vol. 1025 page： 316-324 2004

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1196/annals.1316.039

Web of Science
Modification of human 5-HT2C receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution Reviewed

Okada M, Northrup JK, Ozaki N, Russell JT, Linnoila M, Goldman D

MOLECULAR PSYCHIATRY Vol. 9 ( 1 ) page： 55-64 2004

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/sj.mp.4001357

Web of Science
No association is found between the candidate genes of t-PA/plasminogen system and Japanese methamphetamine-related disorder - A collaborative study by the Japanese genetics initiative for drug abuse Reviewed

Iwata N, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iyo M, Sora I, Ujike H, Ozaki N

CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY Vol. 1025 page： 34-38 2004

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1196/annals.1316.004

Web of Science
No association found between the type 1 sigma receptor gene polymorphisms and methamphetamine abuse in the Japanese population Reviewed

Inada T, Iijima Y, Uchida N, Maeda T, Iwashita S, Ozaki N, Harano M, Komiyama T, Yamada M, Sekine Y, Iyo M, Sora I, Ujike H

CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY Vol. 1025 page： 27-33 2004

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1196/annals.1316.003

Web of Science
Pharmacogenetics of antipsychotics

Ozaki Norio

Nagoya J Med Sci Vol. 67 ( 1-2 ) page： 1-7 2004

　More details

Language：English
Study of association between alpha-synuclein gene polymorphism and methamphetamine psychosis/dependence Reviewed

Kobayashi H, Ide S, Hasegawa J, Ujike H, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Shen HW, Ikeda K, Sora I

CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY Vol. 1025 page： 325-334 2004

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1196/annals.1316.040

Web of Science
うつ病による自殺をいかに予防するか　職域におけるうつ病の早期発見と社会復帰を目指したサポート

尾崎　紀夫

臨床精神薬理 Vol. 7 ( 4 ) page： 698-706 2004

　More details

Language：Japanese Publishing type：Research paper (scientific journal)
感情障害発症関連遺伝子

尾崎　紀夫

Vol. 22 ( 2 ) page： 138-43 2004

　More details

Language：Japanese Publishing type：Research paper (scientific journal)
ハミルトンうつ病評価尺度

尾崎　紀夫

ストレス疾患ナビゲーター page： 116-117 2004

　More details

Language：Japanese Publishing type：Research paper (scientific journal)
うつ病に伴う睡眠障害（不眠）をいかに治療するか

尾崎　紀夫

カレントセラピー Vol. 22 ( 7 ) page： 73-75 2004

　More details

Language：Japanese Publishing type：Research paper (scientific journal)
精神科薬物療法の限界：精神科研修医に伝えたいこと

尾崎　紀夫

こころの科学 Vol. 116 page： 21-27 2004

　More details

Language：Japanese
Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis Reviewed

Ujike H, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y, Sora I, Iyo M, Katsu T, Nomura A, Otani K, Morita Y, Ozaki N, Kuroda S

EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 13 page： S418-S418 2003.9

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia Reviewed

Suzuki T, Iwata N, Kitamura Y, Kitajima T, Yamanouchi Y, Ikeda M, Nishiyama T, Kamatani N, Ozaki N

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 121B ( 1 ) page： 7-13 2003.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.20060

Web of Science
Pepstatin A induces extracellular acidification distinct from aspartic protease inhibition in microglial cell lines Reviewed

Okada M, Irie S, Sawada M, Urae R, Urae A, Iwata N, Ozaki N, Akazawa K, Nakanishi H

GLIA Vol. 43 ( 2 ) page： 167-174 2003.8

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/glia.10237

Web of Science
Initial genome-wide scan for linkage with schizophrenia in the Japanese Schizophrenia Sib-pair Linkage Group (JSSLG) families Reviewed

Arinami T, Ishiguro H, Minowa Y, Ohtsuki T, Tsujita T, Imamura A, Yoshikawa T, Toyota T, Yamada K, Shimizu H, Yoshitsugu K, Shibata H, Fujii Y, Fukumaki Y, Tashiro N, Inada T, Iijima Y, Kitao Y, Furuno T, Someya T, Muratake T, Kaneko N, Tsuji S, Mineta M, Takeichi M, Ujike H, Takehisa Y, Tanaka Y, Nakata K, Kitajima T, Nishiyama T, Yamanouchi Y, Iwata N, Ozaki N, Ohara K, Shibuya H, Ohara K, Suzuki Y, Ohmori O, Shinkai T, Hori H, Nakamura J, Kojima T, Takahashi S, Tanabe E, Yara K, Nanko S, Yoneda H, Koh J, Sakai J, Inada Y, Kusumi I, Kameda K, Koyama T, Fukuzako H, Hashiguchi T, Tanabe K, Okazaki Y

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 120B ( 1 ) page： 22-28 2003.7

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ajmg.b.20022

Web of Science
Recombinant human serotonin 5A receptors stably expressed in C6 ghoma cells couple to multiple signal transduction pathways Reviewed

Noda M, Yasuda S, Oka N, Higashida H, Shimada A, Iwata N, Ozaki N, Nishikawa K, Sbirasawa S, Uchida M, Aoki S, Wada K

JOURNAL OF NEUROCHEMISTRY Vol. 84 ( 2 ) page： 222-232 2003.1

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Psychopharmacogenetics

Ozaki N

Encyclopedia of Human Genome Vol. 4 page： 917-922 2003

　More details

Language：English
Association of Novel Genetic Variants in the Serotonin 5-HT4 Receptor Gene (HTR4) with Japanese Schizophrenia.

Ozaki Norio

Am J Med Genet Vol. 121Ｂ ( １ ) page： 22-28 2003

　More details

Language：English Publishing type：Research paper (scientific journal)
Effect of DRD2, 5-HT2A, and COMT genes on antipsychotic response to risperidone Reviewed

Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Ikeda M, Ozaki N

PHARMACOGENOMICS JOURNAL Vol. 3 ( 6 ) page： 356-361 2003

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/sj.tpj.6500211

Web of Science
Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis Reviewed

Ujike H, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y, Sora I, Iyo M, Katsu T, Nomura A, Nakata K, Ozaki N

PHARMACOGENOMICS JOURNAL Vol. 3 ( 4 ) page： 242-247 2003

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/sj.tpj.6500189

Web of Science
Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype Reviewed

Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J, Rudnick G, Murphy DL

MOLECULAR PSYCHIATRY Vol. 8 ( 11 ) page： 933-936 2003

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/sj.mp.4001365

Web of Science
Mutation screening of the human 5-HT4 receptor gene in Japanese schizophrenia Reviewed

Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Ikeda M, Nishiyama T, Abe T, Ozaki N

AMERICAN JOURNAL OF MEDICAL GENETICS Vol. 114 ( 7 ) page： 800-800 2002.10

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Evaluating the state dependency of the Temperament and Character Inventory dimensions in patients with major depression: a methodological contribution Reviewed

Hirano S, Sato T, Narita T, Kusunoki K, Ozaki N, Kimura S, Takahashi T, Sakado K, Uehara T

JOURNAL OF AFFECTIVE DISORDERS Vol. 69 ( 1-3 ) page： 31-38 2002.5

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Mutation screening of the human Clock gene in circadian rhythm sleep disorders Reviewed

Iwase T, Kajimura N, Uchiyama M, Ebisawa T, Yoshimura K, Kamei Y, Shibui K, Kim K, Kudo Y, Katoh M, Watanabe T, Nakajima T, Ozeki Y, Sugishita M, Hori T, Ikeda M, Toyoshima R, Inoue Y, Yamada N, Mishima K, Nomura M, Ozaki N, Okawa M, Takahashi K, Yamauchi T

PSYCHIATRY RESEARCH Vol. 109 ( 2 ) page： 121-128 2002.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome Reviewed

Ebisawa T, Uchiyama M, Kajimura N, Mishima K, Kamei Y, Katoh M, Watanabe T, Sekimoto M, Shibui K, Kim K, Kudo Y, Ozeki Y, Sugishita M, Toyoshima R, Inoue Y, Yamada N, Nagase T, Ozaki N, Ohara O, Ishida N, Okawa M, Takahashi K, Yamauchi T

EMBO REPORTS Vol. 2 ( 4 ) page： 342-346 2001.4

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Association of a 5-MT5A receptor polymorphism, Pro15Ser, to schizophrenia Reviewed

Iwata N, Ozaki N, Inada T, Goldman D

MOLECULAR PSYCHIATRY Vol. 6 ( 2 ) page： 217-219 2001.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Activation mechanism of brain microglia in patients with diffuse neurofibrillary tangles with calcification: A comparison with Alzheimer disease Reviewed

Imamura K, Sawada M, Ozaki T, Naito H, Iwata T, Ishihara R, Takeuchi T, Shibayama G

ALZHEIMER DISEASE & ASSOCIATED DISORDERS Vol. 15 ( 1 ) page： 45-50 2001

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Inhibition of K+-evoked release of rat striatal 5-hydroxytryptamine by an atypical antidepressant: Trazodone Reviewed

Hatsuda S, Sugita S, Suzuki S, Matsubara M, Ozaki N, Kayukawa Y, Ohara M

NEUROPSYCHOBIOLOGY Vol. 44 ( 2 ) page： 103-107 2001

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Habitual snoring in an outpatient population in Japan Reviewed

Kayukawa Y, Shirakawa S, Hayakawa T, Imai M, Iwata N, Ozaki N, Ohta T

PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 54 ( 4 ) page： 385-391 2000.8

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Low novelty-seeking differentiates obsessive-compulsive disorder from major depression Reviewed

Kusunoki K, Sato T, Taga C, Yoshida T, Komori K, Narita T, Hirano S, Iwata N, Ozaki N

ACTA PSYCHIATRICA SCANDINAVICA Vol. 101 ( 5 ) page： 403-405 2000.5

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Normal values and age-dependent changes in GTP cyclohydrolase I activity in stimulated mononuclear blood cells measured by high-performance liquid chromatography Reviewed

Hibiya M, Ichinose H, Ozaki N, Fujita K, Nishimoto T, Yoshikawa T, Asano Y, Nagatsu T

JOURNAL OF CHROMATOGRAPHY B Vol. 740 ( 1 ) page： 35-42 2000.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
HTR2C Cys23Ser polymorphism in relation to CSF monoamine metabolite concentrations and DSM-III-R psychiatric diagnoses Reviewed

Lappalainen J, Long JC, Virkkunen M, Ozaki N, Goldman D, Linnoila M

BIOLOGICAL PSYCHIATRY Vol. 46 ( 6 ) page： 821-826 1999.9

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
The role of genetic factors in the etiology of seasonal affective disorder and seasonality Reviewed

Sher L, Goldman D, Ozaki N, Rosenthal NE

JOURNAL OF AFFECTIVE DISORDERS Vol. 53 ( 3 ) page： 203-210 1999.6

　More details

Language：English

Web of Science
Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations Reviewed

Lappalainen J, Long JC, Eggert M, Ozaki N, Robin RW, Brown GL, Naukkarinen H, Virkkunen M, Linnoila M, Goldman D

ARCHIVES OF GENERAL PSYCHIATRY Vol. 55 ( 11 ) page： 989-994 1998.11

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder Reviewed

Rosenthal NE, Mazzanti CM, Barnett RL, Hardin TA, Turner EH, Lam GK, Ozaki N, Goldman D

MOLECULAR PSYCHIATRY Vol. 3 ( 2 ) page： 175-177 1998.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Dysfunctional parenting and a lifetime history of depression in a volunteer sample of Japanese workers Reviewed

Sato T, Uehara T, Sakado K, Nishioka K, Ozaki N, Nakamura M, Kasahara Y

ACTA PSYCHIATRICA SCANDINAVICA Vol. 96 ( 4 ) page： 306-310 1997.10

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization Reviewed

Ozaki N, Manji H, Lubierman V, Lu SJ, Lappalainen J, Rosenthal NE, Goldman D

JOURNAL OF NEUROCHEMISTRY Vol. 68 ( 5 ) page： 2186-2193 1997.5

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Effects of meta-chlorophenylpiperazine infusions in patients with seasonal affective disorder and healthy control subjects - Diurnal responses and nocturnal regulatory mechanisms Reviewed

Schwartz PJ, Murphy DL, Wehr TA, GarciaBorreguero D, Oren DA, Moul DE, Ozaki N, Snelbaker AJ, Rosenthal NE

ARCHIVES OF GENERAL PSYCHIATRY Vol. 54 ( 4 ) page： 375-385 1997.4

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Two naturally occurring amino acid substitutions of the 5-HT2A receptor: Similar prevalence in patients with seasonal affective disorder and controls Reviewed

Ozaki, N; Rosenthal, NE; Pesonen, U; Lappalainen, J; FeldmanNaim, S; Schwartz, PJ; Turner, EH; Goldman, D

BIOLOGICAL PSYCHIATRY Vol. 40 ( 12 ) page： 1267-1272 1996.12

　More details

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/0006-3223(95)00649-4

Web of Science
Clozapine response and the 5HT(2C)Cys(23)Ser polymorphism Reviewed

Malhotra AK, Goldman D, Ozaki N, Rooney W, Clifton A, Buchanan RW, Breier A, Pickar D

NEUROREPORT Vol. 7 ( 13 ) page： 2100-2102 1996.9

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine Reviewed

Malhotra AK, Goldman D, Ozaki N, Breier A, Buchanan R, Pickar D

AMERICAN JOURNAL OF PSYCHIATRY Vol. 153 ( 8 ) page： 1092-1094 1996.8

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
Direct analysis of candidate genes in impulsive behaviours Reviewed

Goldman D, Lappalainen J, Ozaki N

GENETICS OF CRIMINAL AND ANTISOCIAL BEHAVIOUR Vol. 194 page： 139-152 1996

　More details

Language：English

Web of Science
Effects of season on electro-oculographic ratio in winter seasonal affective disorder Reviewed

Ozaki N, Rosenthal NE, Myers F, Schwartz PJ, Oren DA

PSYCHIATRY RESEARCH Vol. 59 ( 1-2 ) page： 151-155 1995.11

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
PREVALENCE OF SEASONAL DIFFICULTIES IN MOOD AND BEHAVIOR AMONG JAPANESE CIVIL-SERVANTS Reviewed

OZAKI N, ONO Y, ITO A, ROSENTHAL NE

AMERICAN JOURNAL OF PSYCHIATRY Vol. 152 ( 8 ) page： 1225-1227 1995.8

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
IDENTIFICATION, EXPRESSION, AND PHARMACOLOGY OF A CYS(23)-SER(23) SUBSTITUTION IN THE HUMAN 5-HT2C RECEPTOR GENE (HTR2C) Reviewed

LAPPALAINEN J, ZHANG L, DEAN M, OZ M, OZAKI N, YU DH, VIRKKUNEN M, WEIGHT F, LINNOILA M, GOLDMAN D

GENOMICS Vol. 27 ( 2 ) page： 274-279 1995.5

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
MAPPING OF THE SEROTONIN 5-HT1D-ALPHA AUTORECEPTOR GENE (HTR1D) ON CHROMOSOME-1 USING A SILENT POLYMORPHISM IN THE CODING REGION Reviewed

OZAKI N, LAPPALAINEN J, DEAN M, VIRKKUNEN M, LINNOILA M, GOLDMAN D

AMERICAN JOURNAL OF MEDICAL GENETICS Vol. 60 ( 2 ) page： 162-164 1995.4

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
PLATELET [H-3] PAROXETINE BINDING, 5-HT-STIMULATED CA2+ RESPONSE, AND 5-HT CONTENT IN WINTER SEASONAL AFFECTIVE-DISORDER Reviewed

OZAKI N, ROSENTHAL NE, MAZZOLA P, CHIUEH CC, HARDIN T, GARCIABORREGUERO D, SCHWARTZ PJ, TURNER E, OREN DA, MURPHY DL

BIOLOGICAL PSYCHIATRY Vol. 36 ( 7 ) page： 458-466 1994.10

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
LONG-TERM FOLLOW-UP-STUDY ON SLEEP-WAKE RHYTHM DISORDERS - COMPREHENSIVE SURVEY OF PATIENTS IN ADOLESCENT AND ADULT Reviewed

OHTA T, HAYAKAWA T, ITO A, ANDO K, OZAKI N, KOGAWA S, IMAI M, YAMAGUCHI N, KOYAMA E, YAMAMOTO S, ABIRU T, IWATA T, KAYUKAWA Y, OKADA T

JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY Vol. 48 ( 2 ) page： 455-457 1994.6

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
DIURNAL-VARIATIONS OF SEROTONIN AND DOPAMINE LEVELS IN DISCRETE BRAIN-REGIONS OF SYRIAN-HAMSTERS AND THEIR MODIFICATION BY CHRONIC CLORGYLINE TREATMENT Reviewed

OZAKI N, DUNCAN WC, JOHNSON KA, WEHR TA

BRAIN RESEARCH Vol. 627 ( 1 ) page： 41-48 1993.11

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
EFFECTS OF PHOTOTHERAPY WINTER SEASONAL AFFECTIVE-DISORDER ON ELECTROOCULOGRAPHIC RATIO IN WINTER SEASONAL AFFECTIVE-DISORDER Reviewed

OZAKI N, ROSENTHAL NE, MOUL DE, SCHWARTZ PJ, OREN DA

PSYCHIATRY RESEARCH Vol. 49 ( 2 ) page： 99-107 1993.11

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
DIFFERENTIAL EFFECT OF SELF-STIMULATION ON DOPAMINE RELEASE AND METABOLISM IN THE RAT MEDIAL FRONTAL-CORTEX, NUCLEUS-ACCUMBENS AND STRIATUM STUDIED BY INVIVO MICRODIALYSIS Reviewed

NAKAHARA D, FUCHIKAMI K, OZAKI N, IWASAKI T, NAGATSU T

BRAIN RESEARCH Vol. 574 ( 1-2 ) page： 164-170 1992.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
PREVALENCE OF SEASONAL MOOD CHANGES IN LOW LATITUDE AREA - SEASONAL PATTERN ASSESSMENT QUESTIONNAIRE SCORE OF QUEZON CITY WORKERS Reviewed

ITO A, ICHIHARA M, HISANAGA N, ONO Y, KAYUKAWA Y, OHTA T, OKADA T, OZAKI N

JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY Vol. 46 ( 1 ) page： 249-249 1992.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
TREATMENT OF PERSISTENT SLEEP-WAKE SCHEDULE DISORDERS IN ADOLESCENTS WITH METHYLCOBALAMIN (VITAMIN-B12) Reviewed

OHTA T, ANDO K, IWATA T, OZAKI N, KAYUKAWA Y, TERASHIMA M, OKADA T, KASAHARA Y

SLEEP Vol. 14 ( 5 ) page： 414-418 1991.10

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
THE EFFECT OF METHAMPHETAMINE ON SEROTONIN AND ITS METABOLITE IN THE SUPRACHIASMATIC NUCLEUS - A MICRODIALYSIS STUDY Reviewed

OZAKI N, NAKAHARA D, KASAHARA Y, NAGATSU T

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION Vol. 86 ( 3 ) page： 175-179 1991

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
THE PLASMA TETRAHYDROBIOPTERIN LEVELS IN PATIENTS WITH AFFECTIVE-DISORDERS Reviewed

HASHIMOTO R, OZAKI N, OHTA T, KASAHARA Y, KANEDA N, NAGATSU T

BIOLOGICAL PSYCHIATRY Vol. 28 ( 6 ) page： 526-528 1990.9

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
PLASMA TETRAHYDROBIOPTERIN LEVELS IN PATIENTS WITH PSYCHIATRIC-DISORDERS Reviewed

HASHIMOTO R, OZAKI N, OHTA T, KASAHARA Y, KANEDA N, NAGATSU T

NEUROPSYCHOBIOLOGY Vol. 23 ( 3 ) page： 140-143 1990

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
EFFECTS OF APOMORPHINE ON INVIVO RELEASE OF DOPAMINE AND ITS METABOLITES IN THE PREFRONTAL CORTEX AND THE STRIATUM, STUDIED BY A MICRODIALYSIS METHOD Reviewed

OZAKI N, NAKAHARA D, MIURA H, KASAHARA Y, NAGATSU T

JOURNAL OF NEUROCHEMISTRY Vol. 53 ( 6 ) page： 1861-1864 1989.12

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
THE EFFECT OF UPTAKE INHIBITION ON DOPAMINE RELEASE FROM THE NUCLEUS ACCUMBENS OF RATS DURING SELF-STIMULATION OR FORCED STIMULATION OF THE MEDIAL FOREBRAIN-BUNDLE - A MICRODIALYSIS STUDY Reviewed

NAKAHARA D, OZAKI N, KAPOOR V, NAGATSU T

NEUROSCIENCE LETTERS Vol. 104 ( 1-2 ) page： 136-140 1989.9

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
INCREASED DOPAMINE AND SEROTONIN METABOLISM IN RAT NUCLEUS ACCUMBENS PRODUCED BY INTRACRANIAL SELF-STIMULATION OF MEDIAL FOREBRAIN-BUNDLE AS MEASURED BY INVIVO MICRODIALYSIS Reviewed

NAKAHARA D, OZAKI N, MIURA Y, MIURA H, NAGATSU T

BRAIN RESEARCH Vol. 495 ( 1 ) page： 178-181 1989.8

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
A TREATMENT TRIAL OF DELAYED SLEEP PHASE SYNDROME WITH TRIAZOLAM Reviewed

OZAKI N, IWATA T, ITOH A, OHTA T, OKADA T, KASAHARA Y

JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY Vol. 43 ( 1 ) page： 51-55 1989.3

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
EFFECTS OF HETEROCYCLIC AMINES IN FOOD ON DOPAMINE METABOLISM IN NIGRO-STRIATAL DOPAMINERGIC-NEURONS Reviewed

ICHINOSE H, OZAKI N, NAKAHARA D, NAOI M, WAKABAYASHI K, SUGIMURA T, NAGATSU T

BIOCHEMICAL PHARMACOLOGY Vol. 37 ( 17 ) page： 3289-3295 1988.9

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
INACTIVATION OF TYROSINE-HYDROXYLASE IN RAT STRIATUM BY 1-METHYL-4-PHENYLPYRIDINIUM ION (MPP+) Reviewed

OZAKI N, NAKAHARA D, MOGI M, HARADA M, KIUCHI K, KANEDA N, MIURA Y, KASAHARA Y, NAGATSU T

NEUROSCIENCE LETTERS Vol. 85 ( 2 ) page： 228-232 1988.2

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
PLASMA BIOPTERIN LEVELS OF PATIENTS WITH AFFECTIVE-DISORDERS Reviewed

HASHIMOTO R, OZAKI N, OHTA T, KASAHARA Y, KANEDA N, NAGATSU T

NEUROPSYCHOBIOLOGY Vol. 19 ( 2 ) page： 61-63 1988

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
BODY-TEMPERATURE MONITORING IN SUBJECTS WITH DELAYED SLEEP PHASE SYNDROME Reviewed

OZAKI N, IWATA T, ITOH A, KOGAWA S, OHTA T, OKADA T, KASAHARA Y

NEUROPSYCHOBIOLOGY Vol. 20 ( 4 ) page： 174-177 1988

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
INTRACEREBRALLY ADMINISTERED (6R)-L-ERYTHRO-TETRAHYDROBIOPTERIN DOES NOT AFFECT EXTRACELLULAR LEVELS OF DOPAMINE AND SEROTONIN METABOLITES IN RAT STRIATUM INVIVO DURING MEASUREMENT BY BRAIN MICRO-DIALYSIS SYSTEM Reviewed

NAKAHARA D, OZAKI N, KANEDA N, KIUCHI K, OKADA T, OHTA T, NAGATSU T

NEUROCHEMISTRY INTERNATIONAL Vol. 12 ( 2 ) page： 121-124 1988

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
ACUTE EFFECTS OF 1-METHYL-4-PHENYLPYRIDINIUM ION (MPP+) ON DOPAMINE AND SEROTONIN METABOLISM IN RAT STRIATUM AS ASSAYED INVIVO BY A MICRO-DIALYSIS TECHNIQUE Reviewed

OZAKI N, NAKAHARA D, KANEDA N, KIUCHI K, OKADA T, KASAHARA Y, NAGATSU T

JOURNAL OF NEURAL TRANSMISSION Vol. 70 ( 3-4 ) page： 241-250 1987

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
TOTAL BIOPTERIN LEVELS OF PLASMA IN PATIENTS WITH DEPRESSION Reviewed

HASHIMOTO R, OZAKI N, OHTA T, KASAHARA Y, KANEDA N, NAGATSU T

NEUROPSYCHOBIOLOGY Vol. 17 ( 4 ) page： 176-177 1987

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science
PLASMA NOREPINEPHRINE IN SLEEP-APNEA SYNDROME Reviewed

OZAKI N, OKADA T, IWATA T, OHTA T, KASAHARA Y, KIUCHI K, NAGATSU T

NEUROPSYCHOBIOLOGY Vol. 16 ( 2-3 ) page： 88-92 1986

　More details

Language：English Publishing type：Research paper (scientific journal)

Web of Science

▼display all

To the head of Papers.▲

Books 8

標準精神医学第5版

編集：樋口輝彦,野村総一郎,尾崎紀夫,朝田隆（ Role： Joint author）

医学書院 2012.3 （ ISBN:978-4-260-01407-6 ）

　More details

Language：Japanese
気分障害

編者：上島国利, 野村総一郎 ,大野裕,樋口輝彦 ,尾崎紀夫,神庭重信（ Role： Joint author）

医学書院 2008.6

　More details

Language：Japanese
精神神経薬理学大事典

編著：シャッツバーグ、ネメロフ総監訳：兼子直、尾崎紀夫（ Role： Joint author）

西村書店 2009.5

　More details

Language：Japanese
うつ病リワークプログラムのはじめ方

尾崎紀夫他（ Role： Joint author）

弘文堂 2009.7

　More details

Language：Japanese
うつ病リワークプログラムの続け方-スタッフのために

尾崎紀夫他（ Role： Sole author）

南山堂 2011.6

　More details

Language：Japanese
基礎からの睡眠医学

編者：古池保雄, 中田誠一, 野田明子, 尾崎紀夫（ Role： Joint author）

名古屋大学出版会 2010.5

　More details

Language：Japanese
精神疾患の薬物療法ガイド

編者：稲田俊也,稲垣中,尾崎紀夫,伊豫雅臣（ Role： Joint author）

星和書店 2008.2

　More details

Language：Japanese
双極性障害の心理教育マニュアル：患者に何をどう伝えるか

監訳：秋山剛, 尾崎紀夫（ Role： Joint author）

医学書院 2012.4

　More details

Language：Japanese

▼display all

To the head of Books.▲

MISC 2

White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals Reviewed

Koshiyama D, Fukunaga M, Okada N, Morita K, Nemoto K, Usui K, Yamamori H, Yasuda Y, Fujimoto M, Kudo N, Azechi H, Watanabe Y, Hashimoto N, Narita H, Kusumi I, Ohi K, Shimada T, Kataoka Y, Yamamoto M, Ozaki N, Okada G, Okamoto Y, Harada K, Matsuo K, Yamasue H, Abe O, Hashimoto R, Takahashi T, Hori T, Nakataki M, Onitsuka T, Holleran L, Jahanshad N, van Erp TGM, Turner J, Donohoe G, Thompson PM, Kasai K, Hashimoto R, COCORO.

Molecular psychiatry 2019.11

　More details

DOI： 10.1038/s41380-019-0553-7

PubMed
Oral medicine psychiatric liaison clinic: study of 1202 patients attending over an 18-year period. Reviewed

Umemura, E. Tokura, T. Ito, M. Kobayashi, Y. Tachibana, M. Miyauchi, T. Tonoike, T. Nagashima, W. Kimura, H. Arao, M. Sato Boku, A. Ozaki, N. Kurita, K.

Int J Oral Maxillofac Surg Vol. 48 ( 5 ) page： 644-650 2019.1

To the head of MISC.▲

Presentations 30

Can a SNP on splicing variant of HTR4 predict post psychotic depression or anxiety? International conference

12th World Congress on Psychiatric Genetics

　More details

Event date： 2004

Language：English
IMPA2遺伝子プロモーター領域に存在する気分障害リスクハプロタイプ

第26回日本生物学的精神医学会

　More details

Event date： 2004

Language：Japanese

Country：Japan
NQO遺伝子多型と覚醒剤乱用との関連研究

第26回日本生物学的精神医学会

　More details

Event date： 2004

Language：Japanese

Country：Japan
大うつ病患者における治療前後の状態像と血漿神経ステロイドの関係

第26回日本生物学的精神医学会

　More details

Event date： 2004

Language：Japanese

Country：Japan
メタンフェタミン依存とオピオイド関連受容体遺伝子多型に関する相関研究

第26回日本生物学的精神医学会

　More details

Event date： 2004

Language：Japanese

Country：Japan
グルタチオンSトランスフェラーゼM1(GSTM1)遺伝子欠損と覚醒剤乱用者の関連研究

第26回日本生物学的精神医学会

　More details

Event date： 2004

Language：Japanese

Country：Japan
Chimerin2遺伝子のH204Rミスセンス多型は男性において統合失調症と関連する

第26回日本生物学的精神医学会

　More details

Event date： 2004

Language：Japanese

Country：Japan
統合失調症脆弱性遺伝子ディスバインジンの関連解析と神経細胞における機能解析

第26回日本生物学的精神医学会

　More details

Event date： 2004

Language：Japanese

Country：Japan
BDNF遺伝子と覚醒剤乱用者の関連研究

第26回日本生物学的精神医学会

　More details

Event date： 2004

Language：Japanese

Country：Japan
移植手術のドナーに対する精神医学的介入の重要性

第17回日本総合病院精神医学会総会

　More details

Event date： 2004

Language：Japanese

Country：Japan
他科からの転科・転棟依頼において苦慮した状況とその対応策

第17会日本総合病院精神医学会総会

　More details

Event date： 2004

Language：Japanese

Country：Japan
統合失調症ゲノム研究と臨床薬理学研究との架橋を目指して

第14会日本臨床精神神経薬理学会　シンポジウム「分子精神医学の進歩と精神科薬物療法」

　More details

Event date： 2004

Language：Japanese

Country：Japan
Paroxetineの副作用発現とCYP2D6及びセロトニン系遺伝子多型との関連

第14回日本臨床精神神経薬理学会

　More details

Event date： 2004

Language：Japanese

Country：Japan
統合失調症患者における血中クロモグラニンA濃度の変動

第14回日本臨床精神神経薬理学会

　More details

Event date： 2004

Language：Japanese

Country：Japan
Genomic research of schizophrenia: from candidate gene and pharmacogenetic approach to whole genome study International conference

WFSBP Asian Pacific Congress: Plenary Lecture

　More details

Event date： 2004

Language：English
Central cannabinoid receptor gene (CNR1) and schizophrenia International conference

International Congress of Biological Psychiarty

　More details

Event date： 2004

Language：English
AKT1と日本人統合失調症との関連解析

第26回日本生物学的精神医学会

　More details

Event date： 2004

Language：Japanese

Country：Japan
No Association between GABAA cluster on 5q and Japanese schizophrenia International conference

12th World Congress on Psychiatric Genetics

　More details

Event date： 2004

Language：English
非定型抗精神病薬導入後の統合失調症治療の動向

日本薬理学会　ランチョンセミナー

　More details

Event date： 2004

Language：Japanese

Country：Japan
総合病院における精神病性障害（統合失調症を中心に）の治療

日本総合病院精神医学会ランチョンセミナー

　More details

Event date： 2004

Language：Japanese

Country：Japan
パルスオキシメータによる動脈血酸素飽和度低下度判定基準の相違による睡眠呼吸障害重症度指標への影響

日本睡眠学会第2回定期学術集会

　More details

Event date： 2004

Language：Japanese

Country：Japan
職場復帰を目指したメンタルヘルス対策：うつ病を中心に

日本産業衛生学会　北陸甲信越地方総会　教育講演

　More details

Event date： 2004

Language：Japanese

Country：Japan
運転業務とメンタルヘルス：向精神薬（抗うつ薬、抗不安薬、睡眠道乳剤）が与える運転技能への影響を中心に

第13回日本交通医学工学研究会・シンポジウム「人と車・環境」

　More details

Event date： 2004

Language：Japanese

Country：Japan
新規抗精神病薬導入後の統合失調症治療の方向性

第57回九州精神神経学会ランチョンセミナー

　More details

Event date： 2004

Language：Japanese

Country：Japan
5-HT2C受容体遺伝子(HTR2C)の多型検索と統合失調症との関連研究

第26回日本生物学的精神医学会

　More details

Event date： 2004

Language：Japanese

Country：Japan
統合失調症の病態解明に向けて：誤解・偏見と難治性の克服を目指して

第45回日本児童青年精神医学会総会・教育講演

　More details

Event date： 2004

Language：Japanese

Country：Japan
覚醒剤精神病におけるSOD2の相関研究

第26回日本生物学的精神医学会

　More details

Event date： 2004

Language：Japanese

Country：Japan
Prodynorphin遺伝子のプロモーター領域の機能的多型と覚せい剤依存症との関連研究

第26回日本生物学的精神医学会

　More details

Event date： 2004

Language：Japanese
Calcineurin遺伝子(PPP3CC)と統合失調症の関連研究

第26回日本生物学的精神医学会

　More details

Event date： 2004

Language：Japanese

Country：Japan
双極性障害におけるChromograninB遺伝子の大規模関連解析

第26回日本生物学的精神医学会

　More details

Event date： 2004

Language：Japanese

Country：Japan

▼display all

To the head of Presentations.▲

Research Project for Joint Research, Competitive Funding, etc. 25

COVID-19等による社会変動下に即した応急的遠隔対応型メンタルヘルスケアの基盤システム構築と実用化促進にむけた効果検証

2020.11 - 2022.3
精神疾患のヒトゲノム変異を基盤とする神経回路・分子病態に関する研究

2019.4 - 2024.3
精神障害のゲノム変異を起点としたバイオリソースと臨床情報の活用による非競争的フェーズにおける産学連携創薬の基盤構築

2019.4 - 2023.3
精神科トランスレーショナルリサーチの推進に向けた臨床研究システムの開発

2019.4 - 2022.3
血液メタボローム解析による精神疾患の層別化可能な客観的評価法の確立と治療最適化への応用

2018.4 - 2021.3
妊産婦前向き　コホート研究の成果を用いた要介入群の同定法と支援策の開発

2018.4 - 2021.3
精神疾患レジストリの構築・統合により新たな診断・治療法を開発するための研究

2018.4 - 2021.3
精神疾患の病態を反映した鑑別診断、重症度予測が可能な血中バイオマーカーの実用化研究

2015.4 - 2018.3

日本医療研究開発機構障害者対策総合研究開発事業

　 More details

Grant type：Competitive
＜臨床研究総括チーム＞精神・神経疾患患者および健常者の脳画像等データリソース統合にもとづく中核拠点霊長類回路マップと疾患研究チーム患者回路情報の連結＜疾患研究チーム＞大規模脳画像解析とヒト-霊長類を連結するトランスレータブル脳・行動指標開発にもとづく精神疾患の病態神経回路解明

2014.11 - 2019.3

革新的技術による脳機能ネットワークの全容解明プロジェクト

　 More details

Grant type：Competitive
広汎性発達障害と統合失調症のゲノム解析を起点として、発症因に基づく両疾患の診断体系再編と診断法開発を目指した研究：多面発現的効果を有するゲノムコピー数変異（CNV）に着目して

2011.10 - 2016.3

国家基幹研究開発推進　脳科学研究戦略推進プログラム

　 More details

Grant type：Competitive

　本研究は、広汎性発達障害と統合失調症のゲノム解析を起点として、発症因に基づく両疾患の診断体系再編と診断法開発を目指す研究である。
アストロサイト・オリゴデンドロサイト関連遺伝子を標的とした精神病性障害の病態研究

2006
ＤＩＳＣ１結合蛋白を標的とした統合失調症の病態研究

2006
Risperidoneの臨床的効果に対するAKT1およびD1,D5受容体遺伝子の関与の検討

2005

精神医薬研究振興財団研究助成金

　 More details

Grant type：Competitive
統合失調症の検査キット開発

2004

企業からの受託研究
機能性精神疾患のハイスループットSNPs解析と機能解析による創薬標的分子の解明：機能性精神疾患の候補遺伝子関連解析

2004

ヒューマンサイエンス財団

　 More details

Grant type：Competitive
依存性薬物により誘発される精神障害の機構解明

2004

国内共同研究
GABAA受容体アルファ1サブユニット遺伝子の多型検索と統合失調症との関連

2004
Aripiprazoleの5-HT5A受容体サブタイプへの親和性および細胞応答に関する検討

2004

企業からの受託研究
気分障害のゲノム医学研究

2004

企業からの受託研究
勤労者における自殺予防を目的としたうつ病の早期発見方法の開発

2003
精神疾患の分子病態解明による新しい治療・予防法の開発に関する研究：セロトニン系・GABA系を候補とした精神疾患のゲノム研究

2003

厚生省精神・神経疾患研究

　 More details

Grant type：Competitive
セロトニントランスポーター遺伝子多型同定と精神疾患の関連研究

2003
勤労者における自殺予防を目的としたうつ病の早期発見方法

2002 - 2003
依存性薬物により誘発される精神障害の機構の解明

2001 - 2003

国内共同研究
精神科医の産業医としての活用等に関する調査研究

2001 - 2002

▼display all

To the head of Research Project for Joint Research, Competitive Funding, etc..▲

KAKENHI (Grants-in-Aid for Scientific Research) 10

多層的解析による精神疾患の脳・心臓病態解明：Diseasomeの具現化へ

2020.8 - 2023.3

科学研究費補助金挑戦的研究開拓

尾崎　紀夫

　 More details

Authorship：Principal investigator
精神障害の神経・グリアネットワーク病態解明：病態に基づく診断体系構築を目指して

2018.4 - 2021.3

科学研究費補助金基盤研究(A)
白質・ミエリン障害を病因とする統合失調症サブグループの同定

2013.6 - 2018.3

科学研究費補助金新学術領域

　 More details

Authorship：Principal investigator
双極性障害の発症に強く関わる稀な遺伝子変異の同定と包括的な解析による病態解明

2013.4 - 2016.3

科学研究費補助金基盤研究(A)

尾崎紀夫

　 More details

Authorship：Principal investigator
認知機能と神経画像を中間表現型とする統合失調症の分子病態解明

2007.3 - 2010.3

科学研究費補助金基盤研究(B)

尾崎　紀夫

　 More details

Authorship：Principal investigator
精神疾患モデル動物発見を企図したニホンザルを対象とする精神疾患発症関連変異の探索

2013.4 - 2015.3

科学研究費補助金

尾崎紀夫

　 More details

Authorship：Principal investigator
プロテオーム解析による統合失調症と双極性障害の病態に共通する分子の探索　　　　　

2008.4 - 2010.3

科学研究費補助金

尾崎　紀夫

　 More details

Authorship：Principal investigator
次世代シークエンサーを活用した統合失調症のトランスクリプトーム解析

2011.4 - 2013.3

科学研究費補助金

　 More details

Authorship：Principal investigator
１４－３－３εを標的とした統合失調症と気分障害の分子病態解明

2008.4 - 2010.3

科学研究費補助金特定領域研究

尾崎　紀夫

　 More details

Authorship：Principal investigator
脳と免疫系相互作用の観点からの多階層的研究による精神疾患病態解明

Grant number：21H04815 2021.4 - 2024.3

科学研究費助成事業基盤研究(A)

尾崎紀夫, 和氣弘明, 大野欽司, 野田幸裕, 財津桂

　 More details

Authorship：Principal investigator

Grant amount：\42120000 （ Direct Cost: \32400000 、 Indirect Cost：\9720000 ）

脳と免疫系相互作用の観点から精神疾患病態解明の達成を目指し、ゲノム変異を同定した患者由来試料と同一変異に基づくモデル細胞・マウスを用いた多階層的研究を実施する。具体的には、患者ゲノム解析及びゲノム変異患者由来末梢血・腸内細菌・死後脳の解析及びiPS細胞由来神経細胞・オルガノイドの解析。新生仔期免疫活性化状態を経た遺伝子改変マウスの行動解析。ミクログリアと神経細胞の相互作用による神経回路病態解明を目指した、モデルマウスのin vivoイメージング解析。腸内細菌と脳の連関解明を目指した、ヒト・マウスの解析。脳病態と末梢病態との関係の明確化を目指した、ヒト・マウスのインフラマソーム解析。

▼display all

To the head of KAKENHI (Grants-in-Aid for Scientific Research).▲