Updated on 2023/10/20

写真a

 
TAKANO Hideaki
 
Organization
Institute for Advanced Research Assistant Professor
Graduate School of Engineering Assistant Professor
Graduate School
Graduate School of Engineering
Undergraduate School
School of Engineering Chemistry and Biotechnology
Title
Assistant Professor
Contact information
メールアドレス
Homepage
http://www.chembio.nagoya-u.ac.jp/labhp/organic1/index.html
External link

Degree 1

  1. 博士 (理学) （ 2020.3   早稲田大学 ） 

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Research Interests 1

  1. 有機合成化学, 有機金属化学, 計算科学

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Research Areas 1

  1. Nanotechnology/Materials / Synthetic organic chemistry

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Research History 3

  1. Nagoya University   Institute for Advanced Research   Assistant Professor

    2022.12

  2. Hokkaido University   Institute for Chemical Reaction Design and Discovery   Designated assistant professor

    2021.10 - 2022.11

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    Country：Japan

  3. Hokkaido University   Institute for Chemical Reaction Design and Discovery   Researcher

    2020.4 - 2021.9

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    Country：Japan

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Education 2

  1. Waseda University

    2015.4 - 2020.3

  2. Waseda University

    2011.4 - 2015.3

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Professional Memberships 4

  1. 基礎有機化学会

  2. 近畿化学協会

  3. The Society of Synthetic Organic Chemistry

  4. The Chemical Society of Japan

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Awards 5

  1. 第8回北海道大学部局横断シンポジウムベストプレゼンテーション賞

    2022.10   AFIR法に基づくエチレンの二官能基化反応による対称及び非対称DPPE誘導体の合成と配位子への展開

    髙野 秀明

  2. 大津会議アワードフェロー

    2021.2  

  3. 博士学位賞

    2020.3   早稲田大学  

  4. 関根吉郎賞

    2017.3   早稲田大学  

  5. 稲化会賞

    2015.3   早稲田大学  

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Papers 27

  1. Synthesis of BCP-Based Straight-Shaped Diphosphine Ligands Reviewed

    Hideaki Takano, Hitomi Katsuyama, Hiroki Hayashi, Miyu Harukawa, Makoto Tsurui, Sunao Shoji, Yasuchika Hasegawa, Satoshi Maeda, Tsuyoshi Mita

    Angewandte Chemie International Edition     2023.3

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    [1.1.1]Propellane, which is structurally simple and compact, exhibits promising potential for the synthesis of disubstituted straight-shaped bicyclo[1.1.1]pentane (BCP) compounds by manipulation of its highly reactive internal C–C bond. BCPs are considered to be isosteres of 1,4-disubstituted benzenes, which have found broad applications in the areas of functional molecules and drug discovery. The internal C–C single bond of [1.1.1]propellane is regarded as a change-shift bond, which can be readily cleaved by radical or ionic means to construct BCPs. We herein report a novel synthetic method for (un)symmetric diphosphines based on the BCP motif, which can be interpreted as isosteres of 1,4-bis(diphenylphosphino)benzenes. The obtained BCP-diphosphine derivatives were used to generate a straight-shaped Au complex and a Eu-based coordination polymer.

    DOI： 10.26434/chemrxiv-2023-07rdd

  2. Photoredox/HAT-Catalyzed Dearomative Nucleophilic Addition of the CO2 Radical Anion to (Hetero)aromatics Reviewed International journal

    Saeesh R. Mangaonkar, Hiroki Hayashi, Hideaki Takano, Wataru Kanna, Satoshi Maeda, Tsuyoshi Mita

    ACS Catalysis   Vol. 13   page： 2482 - 2488   2023.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ACS  

    DOI： 10.1021/acscatal.2c06192

  3. Prediction of High-Yielding Single-Step or Cascade Pericyclic Reactions for the Synthesis of Complex Synthetic Targets Reviewed International coauthorship

    Tsuyoshi Mita, Hideaki Takano, Hiroki Hayashi, Wataru Kanna, Yu Harabuchi, K. N. Houk, Satoshi Maeda

    Journal of the American Chemical Society     2022.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/jacs.2c09830

  4. Oxidation and Reduction Pathways in the Knowles Hydroamination via a Photoredox‐Catalyzed Radical Reaction** Reviewed

    Yu Harabuchi, Hiroki Hayashi, Hideaki Takano, Tsuyoshi Mita, Satoshi Maeda

    Angewandte Chemie International Edition     2022.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1002/ange.202211936

  5. A theory-driven synthesis of symmetric and unsymmetric 1,2-bis(diphenylphosphino)ethane analogues via radical difunctionalization of ethylene Reviewed

    Hideaki Takano, Hitomi Katsuyama, Hiroki Hayashi, Wataru Kanna, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita

    Nature Communications     2022.11

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41467-022-34546-5

  6. Experimental and Theoretical Evidence for Relativistic Catalytic Activity in C–H Activation of N-Phenylbenzamide Using a Cationic Iridium Complex Reviewed

    Chinami Takashima, Hisaki Kurita, Hideaki Takano, Yasuhiro Ikabata, Takanori Shibata, Hiromi Nakai

    The Journal of Physical Chemistry A     2022.10

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acs.jpca.2c04747

  7. In silico reaction screening with difluorocarbene for N-difluoroalkylative dearomatization of pyridines Reviewed

    Hiroki Hayashi, Hitomi Katsuyama, Hideaki Takano, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita

    Nature Synthesis   Vol. 1 ( 10 ) page： 804 - 814   2022.8

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Quantum chemical calculations are mainly regarded as a method for mechanistic studies in organic chemistry, whereas their use for the simulation of unknown reactions could greatly assist in reaction development. Here we report a strategy for developing multicomponent reactions on the basis of the results of computational reaction simulations. In silico screening of multicomponent reactions with difluorocarbene using the artificial force induced reaction method suggested that cycloadditions between an azomethine ylide and a variety of coupling partners would proceed to generate the corresponding α,α-difluorinated N-heterocyclic compounds. The predicted reaction was successfully realized experimentally, leading to a multicomponent N-difluoroalkylative dearomatization of pyridines involving a pyridinium ylide-mediated 1,3-dipolar cycloaddition with a diverse range of electrophiles such as aldehydes, ketones, imines, alkenes and alkynes. Moreover, the performance of the cycloaddition could be explained by comparing the energy barrier of the desired pathway with that of the competitive undesired pathway, which was also identified by the artificial force induced reaction search.

    DOI： 10.1038/s44160-022-00128-y

    Other Link： https://www.nature.com/articles/s44160-022-00128-y

  8. Synthesis of Symmetric/Unsymmetric DPPE Derivatives via the Radical Difunctionalization of Ethylene: A Theory-Driven Approach

    Hideaki Takano, Hitomi Katsuyama, Hiroki Hayashi, Wataru Kanna, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita

    ChemRxiv     2022.5

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    Authorship：Lead author   Language：English   Publisher：American Chemical Society (ACS)  

    1,2-Bis(diphenylphosphino)ethane (DPPE) and its synthetic analogues are important structural motifs in organic synthesis, particularly as novel diphosphine ligands with a C2-alkyl-linker chain. Since DPPE is known to bind to many metal centers in a bidentate fashion to stabilize the corresponding metal complex via the chelation effect originating from its entropic advantage over monodentate ligands, it is often used in transition-metal-catalyzed transformations, and many unique reactions have been developed using this bidentate ligand. Symmetric DPPE derivatives (Ar12P−CH2−CH2−PAr12) are well-known and readily prepared, but electronically and sterically unsymmetric DPPE (Ar12P−CH2−CH2−PAr22; Ar1 ≠ Ar2) ligands have been less explored, mostly due to the difficulties associated with their preparation. In this study, we disclose a novel synthetic method for not only symmetric but also unsymmetric DPPE derivatives using two phosphine-centered radicals and gaseous ethylene, the latter of which is a useful and fundamental C2 unit that is ubiquitous in industrial processes. The thus obtained unsymmetric DPPE ligands can coordinate to several transition-metal salts in a bidentate fashion to form the corresponding complexes, one of which exhibits distinctly different characteristics than the corresponding symmetric DPPE–metal complex. A feasible radical reaction pathway toward DPPE was successfully designed using the artificial force induced method (AFIR) method, a DFT-based automated reaction path search tool.

    DOI： 10.26434/chemrxiv-2022-r4kkz

  9. Electrochemical Dearomative Dicarboxylation of Heterocycles with Highly Negative Reduction Potentials Reviewed

    Yong You, Wataru Kanna, Hideaki Takano, Hiroki Hayashi, Satoshi Maeda, Tsuyoshi Mita

    Journal of the American Chemical Society   Vol. 144 ( 8 ) page： 3685 - 3695   2022.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/jacs.1c13032

  10. Radical Difunctionalization of Gaseous Ethylene Guided by Quantum Chemical Calculations: Selective Incorporation of Two Molecules of Ethylene Reviewed

    Hideaki Takano , Yong You , Hiroki Hayashi , Yu Harabuchi , Satoshi Maeda , Tsuyoshi Mita

    ACS Omega     2021.11

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acsomega.1c05102

  11. Pt(II)-Chiral Diene-Catalyzed Enantioselective Formal [4+2] Cycloaddition Initiated by C-C Bond Cleavage and Elucidation of a Pt(II)/(IV) Cycle by DFT Calculations Invited Reviewed

    Takanori Shibata , Natsumi Shiozawa , Shun Nishibe , Hideaki Takano , Satoshi Maeda

    Organic Chemistry Frontiers     2021.10

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    Language：English  

    DOI： 10.1039/d1qo01467f

  12. Carboxylation of a Palladacycle Formed via C(sp3)–H Activation: Theory‐Driven Reaction Design Reviewed

    Wataru Kanna , Yu Harabuchi , Hideaki Takano , Hiroki Hayashi , Satoshi Maeda , Tsuyoshi Mita

    Chemistry – An Asian Journal     2021.10

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1002/asia.202100989

  13. Versatile Transformations of Biphenylenes by Transition-Metal Catalysts and Application for the Synthesis of Polycyclic Hydrocarbons Invited Reviewed

    Hideaki Takano , Takanori Shibata

    Journal of Synthetic Organic Chemistry Japan     2021.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.5059/yukigoseikyokaishi.79.849

  14. Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO 2 : Computational Design, Scope, and Applications Reviewed

    Hiroki Hayashi , Hideaki Takano , Hitomi Katsuyama , Yu Harabuchi , Satoshi Maeda , Tsuyoshi Mita

    Chemistry – A European Journal     2021.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1002/chem.202100812

  15. Gold-catalyzed dual C–C bond cleavage of biphenylenes bearing a pendant alkyne at ambient temperature Reviewed

    Hideaki Takano, Sari Okazaki, Shun Nishibe, Takeharu Ito, Natsumi Shiozawa, Natsuhiko Sugimura, Kyalo Stephen Kanyiva,Takanori Shibata

    Organic & Biomolecular Chemistry     2020.7

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    Authorship：Lead author   Language：English  

    DOI： 10.1039/D0OB01211D

  16. Catalytic Enantioselective Synthesis of Axially Chiral Polycyclic Aromatic Hydrocarbons (PAHs) via Regioselective C–C Bond Activation of Biphenylenes Reviewed International coauthorship

    Hideaki Takano , Natsumi Shiozawa , Yoshitane Imai , Kyalo Stephen Kanyiva , Takanori Shibata

    Journal of the American Chemical Society     2020.3

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/jacs.9b12205

  17. カチオン性イリジウム触媒を用いた均一系触媒反応における相対論効果 Reviewed

    髙島 千波, 五十幡 康弘, 栗田 久樹, 高野 秀明, 柴田 高範, 中井 浩巳

        2019.10

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    Language：Japanese  

    DOI： 10.2477/jccj.2019-0021

  18. Consecutive HDDA and TDDA reactions of silicon-tethered tetraynes for the synthesis of dibenzosilole-fused polycyclic compounds and their unique reactivity Reviewed

    Akihito Mitake, Rikako Nagai, Ayato Sekine, Hideaki Takano, Natsuhiko Sugimura, Kyalo Stephen Kanyiva, Takanori Shibata

    Chemical Science   Vol. 6   2019.5

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1039/c9sc00960d

  19. Recent Advances of Biphenylene: Synthesis, Reactions and Uses Reviewed

    Hideaki Takano, Takeharu Ito, Kyalo Stephen Kanyiva, Takanori Shibata

    European Journal of Organic Chemistry     2019.5

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    Authorship：Lead author   Language：English  

    DOI： 10.1002/ejoc.201900111

  20. Enantioselective Synthesis of Nine‐ to Eleven‐Membered Cyclic Polyphenylenes Containing Heteroatoms by Catalytic Intramolecular [2+2+2] Cycloaddition Reviewed

    Takanori Shibata, Toru Fusamae, Hideaki Takano, Natsuhiko Sugimura, Kyalo Stephen Kanyiva

    Asian Journal of Organic Chemistry     2019.3

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    Language：English  

    DOI： 10.1002/ajoc.201900051

  21. α-Amino Acid Sulfonamides as Versatile Sulfonylation Reagents: Silver-Catalyzed Synthesis of Coumarins and Oxindoles by Radical Cyclization Reviewed

    Kyalo Stephen Kanyiva, Daisuke Hamada, Sohei Makino, Hideaki Takano, Takanori Shibata

    European Journal of Organic Chemistry     2018.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1002/ejoc.201800901

  22. Regioselective Activation of a Sterically More Hindered C−C Bond of Biphenylenes Using an Alkene as Both a Directing Group and a Reaction Moiety Reviewed

    Hideaki Takano, Takeharu Ito, Kyalo Stephen Kanyiva, Takanori Shibata

    Chemistry – A European Journal     2018.10

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    Authorship：Lead author   Language：English  

    DOI： 10.1002/chem.201804044

  23. Ir-catalyzed synthesis of substituted tribenzosilepins by dehydrogenative C-H/Si-H coupling Reviewed

    Takanori Shibata , Ninna Uno , Tomoya Sasaki , Hideaki Takano , Tatsuki Sato , Kyalo Stephen Kanyiva

    Journal of Organic Chemistry     2018.4

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    Language：English  

    DOI： 10.1021/acs.joc.8b00233

  24. Intramolecular C−H Alkenylation of N-Alkynylindoles: Exo and Endo Selective Cyclization According to the Choice of Metal Catalyst Reviewed

    Takanori Shibata , Takumi Baba , Hideaki Takano , Kyalo Stephen Kanyiva

    Advanced Synthesis and Catalysis     2017.6

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    Language：English  

    DOI： 10.1002/adsc.201700107

  25. Iridium-Catalyzed Formal [4 + 1] Cycloaddition of Biphenylenes with Alkenes Initiated by C-C Bond Cleavage for the Synthesis of 9,9-Disubstituted Fluorenes Reviewed

    Hideaki Takano , Kyalo Stephen Kanyiva , Takanori Shibata

    Organic Letters     2016.4

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acs.orglett.6b00619

  26. Iridium-catalyzed intramolecular enantioselective c-h alkylation at the C-2 position of N-alkenylindoles Reviewed

    Takanori Shibata , Naoto Ryu , Hideaki Takano

    Advanced Synthesis and Catalysis     2015.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1002/adsc.201401163

  27. Cationic iridium-catalyzed C-H alkylation of 2-substituted pyridine N-oxides with acrylates Reviewed

    Takanori Shibata , Hideaki Takano

    Organic Chemistry Frontiers     2015.4

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    Language：English  

    DOI： 10.1039/c4qo00355a

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Presentations 56

  1. Electrochemical Dearomative Carboxylation of (Hetero)aromatics with CO2 International conference

    Tsuyoshi Mita , Yong You , Wataru Kanna , Hideaki Takano , Hiroki Hayashi , Satoshi Maeda

    The 15th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-15)  2023.11.22 

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    Event date： 2023.11

    Presentation type：Oral presentation (general)  

  2. ペンタフルオロフェニル基をもつ反芳香族ジアザポルフィリンの合成と物性

    大竹耕平・櫻井貴浩・髙野秀明・忍久保 洋

    第33回基礎有機化学討論会   2023.9.13 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Poster presentation  

  3. Automated Reaction-Path Search for Stereospecific Pericyclic Reactions by Quantum-Chemistry-Aided Retrosynthetic Analysis Using the AFIR Method International conference

    Tsuyoshi Mita , Hideaki Takano , Hiroki Hayashi , Wataru Kanna , Yu Harabuchi , K. N. Houk , Satoshi Maeda

    The 6th ICReDD International Symposium  2023.9.10 

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    Event date： 2023.9

    Presentation type：Poster presentation  

  4. Visible-light-promoted Radical Functionalization of Small Molecules to Synthesize Unsymmetric Diphosphine Ligands: Physical Properties and Catalytic Activity of Their Metal Complexes International conference

    Tsuyoshi Mita , Hideaki Takano , Hitomi Katsuyama , Hiroki Hayashi , Miyu Harukawa , Makoto Tsurui , Sunao Shoji , Yasuchika Hasegawa , Wataru Kanna , Yu Harabuchi , Satoshi Maeda

    The 21st International Symposium on Organometallic Chemistry Directed Toward Organic Synthesis (OMCOS 21)  2023.7.27 

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    Event date： 2023.7

    Language：English   Presentation type：Poster presentation  

  5. 光電子移動/HAT触媒を用いた（ヘテロ）芳香環の脱芳香族カルボキシル化

    美多 剛 , Saeesh R. Mangaonkar , 林 裕樹 , 髙野 秀明 , 神名 航 , 原渕 祐 , 前田 理

    日本薬学会第143年会  2023.3.28 

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    Event date： 2023.3

    Language：Japanese   Presentation type：Oral presentation (general)  

  6. アミニウムラジカルと二酸化炭素を用いたオレフィンのアミノカルボキシル化：量子化学計算を活用したβ-アミノ酸の新規合成法の開発

    神名 航, 原渕 祐, 勝山 瞳, 髙野 秀明, 林 裕樹, 美多 剛, 前田 理

    日本化学会 第103春季年会   2023.3.24 

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    Event date： 2023.3

    Language：English   Presentation type：Oral presentation (general)  

  7. プロペランのひずみ解消を駆動力とする三成分反応による非対称ビスホスフィン誘導体の合成

    髙野 秀明, 勝山 瞳, 林 裕樹, 前田 理, 美多 剛

    日本化学会 第103春季年会   2023.3.23 

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    Event date： 2023.3

    Language：Japanese   Presentation type：Oral presentation (general)  

  8. 立体特異的なペリ環状反応の反応自動経路探索：AFIR法による量子化学的逆合成 International coauthorship

    美多 剛, 髙野 秀明, 林 裕樹, 神名 航, 原渕 祐, K. N. Houk, 前田 理

    日本化学会 第103春季年会   2023.3.24 

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    Event date： 2023.3

    Language：Japanese   Presentation type：Oral presentation (general)  

  9. AFIR法に基づくエチレンの二官能基化反応による対称及び非対称DPPE誘導体の合成と配位子への展開

    髙野 秀明, 勝山 瞳, 林 裕樹, 神名 航, 原渕 祐, 前田 理, 美多 剛

    第8回北大・部局横断シンポジウム  2022.10.28 

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    Event date： 2022.10

    Presentation type：Oral presentation (general)  

  10. 電子供与および電子求引性置換基を架橋配位子に導入したEu(III)配位高分子の発光機能

    春川 美友, 髙野 秀明, 美多 剛, 庄司 淳, 伏見 公志, 北川 裕一, 長谷川 靖哉

    錯体化学会第72回討論会  2022.9.26 

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    Event date： 2022.9

    Presentation type：Poster presentation  

  11. Reaction Simulation by Quantum Chemical Calculations for Multicomponent Reactions with Difluorocarbene

    Hiroki Hayashi, Hitomi Katsuyama, Hideaki Takano, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita

    薬学部×ICReDDジョイントシンポジウム  2022.9.15 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Oral presentation (general)  

  12. エチレンガスを用いた対称及び非対称DPPE誘導体の簡便合成法の開発と遷移金属錯体への応用

    髙野 秀明, 勝山 瞳, 林 裕樹, 神名 航, 原渕 祐, 前田 理, 美多 剛

    第68回有機金属化学討論会  2022.9.8 

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    Event date： 2022.9

    Presentation type：Oral presentation (general)  

  13. ドナーアクセプター型リンカーを有するEu(III)配位高分子の合成と光物性

    春川 美友, 髙野 秀明, 美多 剛, 庄司 淳, 伏見 公志, 北川 裕一, 長谷川 靖哉

    第71回高分子討論会  2022.9.6 

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    Event date： 2022.9

    Presentation type：Poster presentation  

  14. Eu(Ⅲ)配位⾼分⼦の架橋部への置換基導⼊と発光機能

    春川 美友, 髙野 秀明, 美多 剛, 庄司 淳, 伏見 公志, 北川 裕一, 長谷川 靖哉

    第33回配位化合物の光化学討論会  2022.8.6 

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    Event date： 2022.8

    Presentation type：Poster presentation  

  15. Synthesis of Unsymmetric DPPE Derivatives from Ethylene: Physical Properties and Catalytic Activities of Their Metal Complexes International conference

    Tsuyoshi Mita, Hideki Takano, Hitomi Katsuyama, Hiroki Hayashi, Wataru Kanna, Yu Harabuchi, Satoshi Maeda

    The 30th International Conference on Organometallic Chemistry (ICOMC 2022)  2022.7.21 

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    Event date： 2022.7

    Presentation type：Oral presentation (general)  

  16. Theory-Driven Carboxylation of a Palladacycle International conference

    Wataru Kanna, Yu Harabuchi, Hideaki Takano, Hiroki Hayashi, Tsuyoshi Mita, Satoshi Maeda

    The 12th Triennial Congress of the World Association of Theoretical and Computational Chemists (WATOC 2020)  2022.7.5 

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    Event date： 2022.7

    Presentation type：Poster presentation  

  17. Synthesis and Photophysical Properties of a Eu(Ⅲ) Coordination Polymer with an Unsymmetric Linker International conference

    Miyu Harukawa, Hideaki Takano, Tsuyoshi Mita, Sunao Shoji, Koji Fushimi, Yuichi Kitagawa, Yasuchika Hasegawa

    17 th International Workshop on Supramolecular Nanoscience of Chemically Programmed Pigments  2022.6.11 

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    Event date： 2022.6

    Presentation type：Poster presentation  

  18. 電解還元法を用いたヘテロ芳香環の脱芳香族ジカルボキシル化反応

    髙野 秀明, You Yong, 神名 航, 林 裕樹, 前田 理, 美多 剛

    第20回次世代を担う有機化学シンポジウム  2022.5.28 

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    Event date： 2022.5

    Presentation type：Oral presentation (general)  

  19. AFIR 法を用いた立体特異的なペリ環状反応の自動経路探索:天然物の自動探索を目指して

    髙野 秀明, 林 裕樹, 神名 航, 原渕 祐, 前田 理, 美多 剛

    第24回理論化学討論会  2022.5.19 

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    Event date： 2022.5

    Presentation type：Oral presentation (general)  

  20. 光電子移動触媒を用いた分子内ヒドロアミノ化反応の触媒サイクル全貌解明

    原渕 祐, 林 裕樹, 髙野 秀明, 美多 剛, 前田 理

    第24回理論化学討論会  2022.5.18 

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    Event date： 2022.5

    Presentation type：Oral presentation (general)  

  21. 量子化学計算を指針としたジフルオロカルベンを用いる三成分反応の設計と具現化

    林 裕樹, 勝山 瞳, 髙野 秀明, 原渕 祐, 前田 理, 美多 剛

    第24回理論化学討論会  2022.5.17 

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    Event date： 2022.5

    Presentation type：Oral presentation (general)  

  22. AFIR法による量子化学的逆合成：立体特異的なペリ環状反応の反応経路自動探索

    美多 剛, 髙野 秀明, 林 裕樹, 神名 航, 原渕 祐, 前田 理

    日本薬学会第142年会  2022.3.27 

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    Event date： 2022.3

    Presentation type：Oral presentation (general)  

  23. CO2ラジカルアニオンを用いるヘテロ芳香環の脱芳香族ダブルカルボキシル化：計算化学を取り入れた反応開発

    美多 剛, You Yong, 神名 航, 髙野 秀明, 林 裕樹, 前田 理

    日本化学会第102春季年会  2022.3.23 

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    Event date： 2022.3

    Presentation type：Oral presentation (general)  

  24. パラダサイクルのカルボキシル化：量子化学計算に基づく新規反応開発

    神名 航, 原渕 祐, 髙野 秀明, 林 裕樹, 美多 剛, 前田 理

    日本化学会第102春季年会  2022.3.23 

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    Event date： 2022.3

    Presentation type：Oral presentation (general)  

  25. 非対称型リンカーを導入したEu(Ⅲ)配位高分子の合成と光物性

    春川 美友, 髙野 秀明, 美多 剛, 庄司 淳, 伏見 公志, 北川 裕一, 長谷川 靖哉

    日本化学会第102春季年会  2022.3.26 

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    Event date： 2022.3

    Presentation type：Oral presentation (general)  

  26. 量子化学計算に基づく新規反応開発：エチレンのダブル官能基化反応による非対称DPPEの合成

    髙野 秀明, 勝山 瞳, 林 裕樹, 神名 航, 原渕 祐, 前田 理, 美多 剛

    日本化学会第102春季年会  2022.3.24 

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    Event date： 2022.3

    Presentation type：Oral presentation (general)  

  27. Carboxylation of a Palladacycle: Reaction Design Driven by Quantum Chemical Calculation International conference

    Wataru Kanna, Yu Harabuchi, Hideaki Takano, Hiroki Hayashi, Tsuyoshi Mita, Satoshi Maeda

    The 4th ICReDD International Symposium  2022.3.12 

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    Event date： 2022.3

    Language：English   Presentation type：Poster presentation  

  28. Electrochemical Dearomative Carboxylation of Heteroaromatic rings Supported by DFT Calculations International conference

    Yong You, Wataru Kanna, Hideaki Takano, Hiroki Hayashi, Satoshi Maeda, Tsuyoshi Mita

    The 4th ICReDD International Symposium  2022.3.11 

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    Event date： 2022.3

    Presentation type：Poster presentation  

  29. Photochemical Radical Double Functionalization of Ethylene Gas Guided by Quantum Chemical Calculations International conference

    Hideki Takano, Hitomi Katsuyama, Hiroki Hayashi, Wataru Kanna, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita

    The 4th ICReDD International Symposium  2022.3.11 

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    Event date： 2022.3

    Presentation type：Poster presentation  

  30. Light-driven radical double functionalization of ethylene gas guided by quantum chemical calculations International conference

    Hideaki Takano, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita

    Pacifichem2021   2021.12.20 

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    Event date： 2021.12

    Language：English   Presentation type：Poster presentation  

  31. Synthesis of difluoroglycine derivatives from amines, difluorocarbene, and CO2: computational design, scope, and application International conference

    Tsuyoshi Mita, Hiroki Hayashi, Hideaki Takano, Hitomi Katsuyama, Yu Harabuchi, Satoshi Maeda

    Pacifichem2021   2021.12.18 

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    Event date： 2021.12

    Language：English   Presentation type：Poster presentation  

  32. ジフルオログリシン誘導体の合成的応用 Invited

    林 裕樹, 髙野 秀明, 勝山 瞳, 原渕 祐, 前田 理, 美多 剛

    第44回フッ素化学討論会 2021年11月16日  2021.11.16 

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    Event date： 2021.11

    Language：Japanese   Presentation type：Oral presentation (general)  

  33. エチレンガスのラジカルダブル官能基化反応を指向したAFIR法に基づく新規反応開発

    髙野 秀明, 美多 剛, 原渕 祐, 前田 理

    第119回有機合成化学協会シンポジウム  2021.11.9 

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    Event date： 2021.11

    Language：Japanese   Presentation type：Oral presentation (general)  

  34. AFIR法に基づくエチレンガスの光触媒を用いたラジカルダブル官能基化反応の開発

    髙野秀明, 美多剛, 原渕祐, 前田理

    第47回反応と合成の進歩シンポジウム  2021.10.5 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Oral presentation (general)  

  35. 量子化学計算を取り入れたパラダサイクルカルボキシル化の手法開発

    神名 航, 原渕 佑, 髙野 秀明, 林 裕樹, 美多 剛, 前田 理

    第67回有機金属化学討論会  2021.9.7 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Poster presentation  

  36. パラダサイクルのカルボキシル化：量子化学計算と合成化学実験による新手法開発

    神名 航, 原渕 佑, 髙野 秀明, 林 裕樹, 美多 剛, 前田 理

    第33回 万有札幌シンポジウム  2021.6.26 

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    Event date： 2021.6

    Language：Japanese   Presentation type：Poster presentation  

  37. 量子化学計算に基づくエチレンガスのラジカルダブル官能基化反応の開発

    髙野 秀明, 美多 剛, 原渕 祐, 前田 理

    日本化学会第101春季年会  2021.3.21 

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    Event date： 2021.3

    Presentation type：Oral presentation (general)  

  38. 室温下における白金-キラルジエン錯体による白金2価-4価サイクルを経由するエナンチオ選択的形式的[4+2]付加環化反応

    西部 駿, 塩澤 夏海, 髙野 秀明, 前田 理, 柴田 高範

    日本化学会第101春季年会  2021.3.20 

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    Event date： 2021.3

    Presentation type：Oral presentation (general)  

  39. 公開 Platinum-Chiral Diene-Catalyzed Enantioselective [4+2] Cycloaddition via Pt(II)/(IV) Cycle under Ambient Temperature and DFT Calculation International conference

    Shun Nishibe, Natsumi Shiozawa, Hideaki Takano, Satoshi Maeda, Takanori Shibata

    The 3th ICReDD International Symposium  2021.2.22 

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    Event date： 2021.2

    Language：English   Presentation type：Poster presentation  

  40. Highly enantioselective synthesis of axially chiral polyaromatic hydrocarbons by transition-metal catalysts Invited

    2021.2.22 

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    Event date： 2021.2

    Language：English   Presentation type：Oral presentation (general)  

  41. 不飽和結合を配向基かつ反応点として用いた立体的に混みあった炭素ー炭素結合の選択的開裂による新規触媒反応の開発 Invited

    不飽和結合を配向基かつ反応点として用いた立体的に混みあった炭素ー炭素結合の選択的開裂による新規触媒反応の開発

    第66回有機金属化学討論会  2019.9.14 

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    Event date： 2019.9

    Language：Japanese   Presentation type：Oral presentation (general)  

  42. Rhodium-catalyzed regioselective activation of sterically hindered C-C bond of Biphenylene International conference

    H. Takano, T. Ito, N. Shiozawa, K. S. Kanyiva, T. Shibata

    ESOC2019 - 21st European Symposium on Organic Chemistry  2019.7.16 

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    Event date： 2019.7

    Language：English   Presentation type：Poster presentation  

  43. ロジウム触媒を用いた立体的に混み合った C-C 結合開裂を伴う分子内環化反応の開発

    髙野秀明

    第52回有機金属若手の会 夏の学校  2019.6.25 

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    Event date： 2019.6

    Language：Japanese   Presentation type：Poster presentation  

  44. 公開 Computational Study of Iridium Complexes as Transition States in Formal [4+1] Cycloaddition of Biphenylene with Alkenes: Rational Explanation of [4+1] Prior to [4+2] Cycloaddition International conference

    H. Takano, N. Sugimura, K. S. Kanyiva, T. Shibata

    The 24th International SPACC Symposium -Metal Complexes for Green and Sustainable Development-  2017.11 

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    Event date： 2017.11

    Language：English   Presentation type：Poster presentation  

  45. イリジウム触媒を用いたビフェニレンとアルケンとの形式的付加環化反応の反応機構解析

    髙野秀明 , 杉村夏彦 , カニヴァ キャロ ステイヴィン , 柴田 高範

    日本化学会第97春季年会  2017.3.18 

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    Event date： 2017.3

    Language：Japanese   Presentation type：Oral presentation (general)  

  46. イリジウム触媒を用いた形式的[4+1]付加環化反応を経る9,9-二置換フルオレン類の合成とDFT計算による反応機構解析

    髙野秀明 , 杉村夏彦 , カニヴァ キャロ ステイヴィン , 柴田高範

    第63回有機金属化学討論会  2016.9.15 

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    Event date： 2016.9

    Language：Japanese   Presentation type：Poster presentation  

  47. Synthesis of 9,9’-Disubstituted Fluorene Derivatives by Iridium Catalyst Initiated by C-C Bond Cleavage of Biphenylenes Invited International conference

    H. Takano

    ISPAC 2016  2016.8.17 

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    Event date： 2016.8

    Language：English   Presentation type：Oral presentation (general)  

  48. Iridium-catalyzed reaction of biphenylenes with alkenes initiated by C-C bond cleavage International conference

    H. Takano , N. Sugimura , K. S. Kanyiva , T. Shibata

    International Conference on Organometallic Chemistry 2016  2016.7.21 

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    Event date： 2016.7

    Language：English   Presentation type：Poster presentation  

  49. イリジウム触媒を用いた C-C 結合開裂を経る[4+1]付加環化反応の開発

    髙野秀明

    第49回有機金属若手の会 夏の学校  2016.7 

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    Event date： 2016.7

    Presentation type：Poster presentation  

  50. ビフェニレンの炭素ー炭素結合開裂を起点とするイリジウム触媒による形式的[4+1]付加環化反応

    髙野秀明 , 杉村夏彦 , カニヴァ キャロ ステイヴィン , 柴田高範

    第109回有機合成シンポジウム  2016.6 

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    Event date： 2016.6

    Language：Japanese   Presentation type：Poster presentation  

  51. イリジウム触媒によるビスホスフィン類の炭素ー炭素結合活性化反応を利用したフルオレン誘導体合成

    髙野秀明 , 杉村夏彦 , カニヴァ キャロ ステイヴィン , 柴田高範

    日本化学会第96春季年会  2016.3.25 

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    Event date： 2016.3

    Language：Japanese   Presentation type：Oral presentation (general)  

  52. C-H alkylation for 2-substituted pyridine N-oxide by a cationic iridium(I) catalyst International conference

    H. Takano , T. Shibata

    Pacifichem2015  2015.12.19 

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    Event date： 2015.12

    Language：English   Presentation type：Poster presentation  

  53. キラルカチオン性イリジウム触媒を用いたインドールの分子内不斉CーHアルキル化

    髙野秀明 , 笠直人 , 柴田高範

    第62回有機金属化学討論会  2015.9.8 

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    Event date： 2015.9

    Language：Japanese   Presentation type：Poster presentation  

  54. Enantioselective intramolecular C-H alkylation at the C-2 position of indole by a chiral cationic iridium(I) catalyst International conference

    H. Takano , N. Ryu , T. Shibata

    OMCOS18  2015.6.30 

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    Event date： 2015.6 - 2015.7

    Language：English   Presentation type：Poster presentation  

  55. カチオン性触媒によるインドールの分子内不斉C-Hアルキル化

    髙野秀明 , 笠直人 , 柴田高範

    モレキュラーキラリティー2015  2015.6 

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    Event date： 2015.6

    Language：Japanese   Presentation type：Poster presentation  

  56. 1価イリジウム触媒を用いるピリジンN-オキシドの2位選択的C-Hアルキル化

    髙野秀明 , 柴田高範

    日本化学会第95春季年会  2015.3.26 

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    Event date： 2015.3

    Language：Japanese   Presentation type：Oral presentation (general)  

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Research Project for Joint Research, Competitive Funding, etc. 5

  1. 反芳香族分子の炭素–炭素結合の開裂を起点とするメタラ芳香族化合物の合成と評価

    2023.6 - 2024.3

    一般研究助成 

  2. 光学活性ホウ素化合物の効率合成法の開発と光学特性を活かした応⽤

    2022.12

    卓越研究員事業 

  3. 三成分反応を利用した非対称ビスホスフィン配位子の簡便合成法の開発

    Grant number：22K14673  2022.4 - 2024.3

    科学研究費助成事業 若手研究  若手研究

    高野 秀明

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

  4. 触媒的不斉炭素ー炭素結合活性化反応を利用した歪んだ縮合多環式芳香族化合物の創製

    Grant number：18J13634  2018.4 - 2020.3

    科学研究費助成事業 特別研究員奨励費  触媒的不斉炭素ー炭素結合活性化反応を利用した歪んだ縮合多環式芳香族化合物の創製

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\1500000 （ Direct Cost: \1500000 ）

  5. 新規カチオン性配位子を有するIr触媒によるメタ位選択的C-Hホウ素化反応の開発

    Grant number：1039950  2018.3 - 2019.3

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Industrial property rights 2

  1. 化合物の新規製造方法、新規化合物および金属触媒

    美多剛, 前田理, 髙野秀明

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    Application no：PCT/JP2022/30598  Date applied：2022.8

  2. 化合物の新規製造方法、新規化合物および金属触媒

    美多剛, 前田理, 髙野秀明

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    Application no：特願2021-131481  Date applied：2021.8

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Media Coverage 3

  1. 計算と実験の融合による新反応開発：対称及び非対称DPPEの簡便合成 Internet

    Chem-Station  Chem-Station  https://www.chem-station.com/blog/2023/01/dppe.html  2023.1

  2. 炭素-炭素結合を組み替えて多環式芳香族化合物を不斉合成する Internet

    Chem-Station  Chem-Station  https://www.chem-station.com/blog/2020/06/pah.html  2023.1

  3. Front Cover: Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO 2 : Computational Design, Scope, and Applications (Chem. Eur. J. 39/2021) Newspaper, magazine

    Chemistry – A European Journal  Chemistry – A European Journal  https://doi.org/10.1002/chem.202101792 

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