Updated on 2024/06/28

写真a

 
OKAMOTO Shuichi
 
Organization
Graduate School of Medicine Assistant Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Title
Assistant Professor
External link

Degree 1

  1. 博士 (医学) ( 2022.9   名古屋大学 ) 

Research Interests 2

  1. 血液凝固異常症

  2. von Willebrand disease(VWD)

Research Areas 1

  1. Life Science / Hematology and medical oncology

Research History 2

  1. Nagoya University

    2019.4 - 2022.9

  2. Nagoya University

    2018.4 - 2019.3

Education 1

  1. Nagoya University

    2017.4 - 2021.3

Professional Memberships 4

  1. 日本内科学会

  2. 日本血液学会

  3. 日本血栓止血学会

  4. 日本輸血細胞治療学会

Awards 1

  1. 第45回日本血栓止血学会学術総会優秀ポスター賞

    2023.6  

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    Award type:Award from Japanese society, conference, symposium, etc. 

 

Papers 18

  1. Basement membrane extract potentiates the endochondral ossification phenotype of bone marrow-derived mesenchymal stem cell-based cartilage organoids Invited Reviewed

    Notoh H, Yamasaki S, Suzuki N, Suzuki A, Okamoto S, Kanematsu T, Suzuki N, Katsumi A, Kojima T, Matsushita T, Tamura S

    Biochem Biophys Res Commun     2024.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  2. Variability in combinations of APTT reagent and substrate plasma for a one-stage clotting assay to measure factor VIII products Invited Reviewed

    Suzuki A, Suzuki N, Kanematsu T, Okamoto S, Suzuki N, Tamura S, Kikuchi R, Katsumi A, Kojima T, Matsushita T

    Int J Lab Hematol     2024.3

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    Language:English  

  3. Clinical course and prognosis of patients with hepatocellular carcinoma and haemophilia Reviewed

    Matsuda N, Imai N, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Okamoto S, Kanematsu T, Suzuki N, Matsushita T, Ishigami M, Kawashima H

    Eur J Gastroenterol Hepatol     page: 1211 - 1215   2023.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  4. The usefulness of tranexamic acid for bleeding symptoms of chronic consumptive coagulopathy complicated by aortic disease: a single-institute, retrospective study of 14 patients. Reviewed

    Suzuki N, Suzuki N, Kawaguchi Y, Okamoto S, Kanematsu T, Katsumi A, Suzuki A, Tamura S, Kojima T, Kiyoi H, Matsushita T

    Thromb J   Vol. 21   page: 10   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  5. VWF-Gly2752Ser, a novel non-cysteine substitution variant in the CK domain, exhibits severe secretory impairment by hampering C-terminal dimer formation Reviewed

    Okamoto S, Tamura S, Sanda N, Odaira K, Hayakawa Y, Mukaide M, Suzuki A, Kanematsu T, Hayakawa F, Katsumi A, Kiyoi H, Kojima T, Matsushita T, Suzuki N

    J Thromb Haemost   Vol. 20 ( 8 ) page: 1784 - 1796   2022.8

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jth.15746

  6. Periosteum-derived podoplanin-expressing stromal cells regulate nascent vascularization during epiphyseal marrow development Reviewed

    Tamura S, Mukaide M, Katsuragi Y, Fujii W, Odaira K, Suzuki N, Tsukiji N, Okamoto S, Suzuki A, Kanematsu T, Katsumi A, Takagi A, Ikeda K, Ueyama J, Hirayama M, Suzuki-Inoue K, Matsushita T, Kojima T, Hayakawa F

    J Biol Chem   Vol. 298 ( 5 )   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbc.2022.101833

  7. F9 mRNA splicing aberration due to a deep Intronic structural variation in a patient with moderate hemophilia B Reviewed

    Odaira K, Kawashima F, Tamura S, Suzuki N, Tokoro M, Hayakawa Y, Suzuki A, Kanematsu T, Okamoto S, Takagi A, Katsumi A, Matsushita T, Shima M, Nogami K, Kojima T, Hayakawa F

    Thromb Res   Vol. 213   page: 91 - 96   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.thromres.2022.03.010

  8. Development and validation of a novel qualitative test for plasma fibrinogen utilizing clot waveform analysis Reviewed

    Suzuki A, Suzuki N, Kanematsu T, Shinohara S, Kurono H, Arai N, Okamoto S, Suzuki N, Tamura S, Kikuchi R, Katsumi A, Kojima T, Matsushita T

      Vol. 12 ( 1 )   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-04464-5

  9. The influence of hepatitis C virus eradication on hepatocarcinogenesis in patients with hemophilia Reviewed

    Inukai Y, Imai N, Yamamoto K, Ito T, Ishizu Y, Honda T, Okamoto S, Kanematsu T, Suzuki N, Matsushita T, Ishigami M, Fujishiro M

    Ann Hepatol   Vol. 27 ( 1 )   2022

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.aohep.2021.100545

  10. Protein S-Leu17Pro disrupts the hydrophobicity of its signal peptide causing a proteasome-dependent degradation Reviewed

    Okada K, Tamura S, Suzuki N, Odaira K, Mukaide M, Fujii W, Katsuragi Y, Suzuki A, Kanematsu T, Okamoto S, Suzuki N, Katsumi A, Matsushita T, Kojima T, Hayakawa F

    Protein S-Leu17Pro disrupts the hydrophobicity of its signal peptide causing a proteasome-dependent degradation   Vol. 210   page: 26 - 32   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.thromres.2021.12.014

  11. Tolerability of Molecular-targeted Agents for Hepatocellular Carcinoma Treatment in Haemophiliacs Reviewed

    Yamamoto T, Imai N, Yamamoto K, Ito T, Ishizu Y, Honda T, Okamoto S, Kanematsu T, Suzuki N, Matsushita T, Ishigami M, Fujishiro M.

      Vol. 41 ( 5 ) page: 2569 - 2573   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.15035

  12. Essential role of a carboxyl-terminal α-helix motif in the secretion of coagulation factor XI Reviewed

    Hayakawa Y, Tamura S, Suzuki N, Odaira K, Tokoro M, Kawashima F, Hayakawa F, Takagi A, Katsumi A, Suzuki A, Okamoto S, Kanematsu T, Matsushita T, Kojima T

    J Thromb Haemost   Vol. 19 ( 4 ) page: 920 - 930   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jth.15242

  13. Impact of variation in reagent combinations for one-stage clotting assay on assay discrepancy in nonsevere haemophilia A Reviewed

    Suzuki A, Suzuki N, Kanematsu T, Okamoto S, Tamura S, Kikuchi R, Katsumi A, Kiyoi H, Kojima T, Matsushita T

    Int J Lab Hematol   Vol. 43 ( 1 ) page: 131 - 138   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ijlh.13335

  14. Safety and efficacy of percutaneous radiofrequency ablation for hepatocellular carcinoma patients with haemophilia Invited Reviewed

    Yamamoto T, Imai N, Yamamoto K, Ito T, Ishizu Y, Honda T, Okamoto S, Kanematsu T, Suzuki N, Matsushita T, Ishigami M, Fujishiro M

    Haemophilia   Vol. 27 ( 1 ) page: 100 - 107   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hae.14220

  15. Aberrant X chromosomal rearrangement through multi-step template switching during sister chromatid formation in a patient with severe hemophilia A Invited Reviewed

    Tokoro M, Tamura S, Suzuki N, Kakihara M, Hattori Y, Odaira K, Suzuki S, Takagi A, Katsumi A, Hayakawa F, Okamoto S, Suzuki A, Kanematsu T, Matsushita T, Kojima T

    Mol Genet Genomic Med   Vol. 8 ( 9 )   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/mgg3.1390

  16. Successful Perioperative Combination of High-Dose FVIII Therapy Followed by Emicizumab in a Patient with Hemophilia A with Inhibitors Reviewed

    Okamoto S, Suzuki N, Suzuki A, Suzuki S, Tamura S, Suzuki M, Takahashi N, Kojima T, Kanematsu T, Kojima T, Kiyoi H, Ishiguro N, Matsushita T

      Vol. 3 ( 4 ) page: e364 - e366   2019.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0039-3401001

  17. 高齢者びまん性大細胞型B細胞性リンパ腫の腫瘤性中枢神経浸潤に対するRituximab、Vincristineとの併用によるHigh-Dose Methotrexate療法の検討 Reviewed

    岡本修一、田中正士、後藤辰徳、中島麻梨絵、名倉英一

    癌と化学療法   Vol. 44 ( 13 ) page: 2109 - 2112   2017.12

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    Authorship:Lead author   Language:Japanese  

  18. Estrogens inhibit food intake in CCK-1 receptor-deficient rats Reviewed

    Okamoto S, Shimizu M, Mizuno A, Higuchi T

    J Physiol Sci   Vol. 60 ( 4 )   2010.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12576-010-0094-y

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Books 5

  1. 臨床に直結する血栓止血学 改訂3版

    ( Role: Contributor)

    中外医学社  2024.6  ( ISBN:978-4-498-22546-6

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    Language:Japanese

  2. 別冊日本臨牀 血液症候群 (第3版) III

    ( Role: Contributor ,  VII 凝固・線溶異常による出血傾向 von Willebrand病)

    日本臨牀社  2023.11 

  3. 検査と技術 9月・増大号 匠から学ぶ血栓止血検査ガイド

    ( Role: Contributor ,  3章 検査プロセス(VWF抗原/VWF活性/VWFマルチマー解析) 5章 疾患まとめ(von WIllebrnd病))

    医学書院  2023.9 

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    Language:Japanese

  4. Frontiers In Haemophilia

    ( Role: Contributor)

    2020 

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    Language:Japanese

  5. 血液フロンティア

    岡本修一、鈴木伸明( Role: Contributor ,  血友病の検査診断法とトピックス)

    医薬ジャーナル社  2019 

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    Language:Japanese

Presentations 17

  1. 血中VWF抗原量が偽高値を呈したMGUSを背景とするAVWSの1例

    岡本修一、鈴木敦夫、田村彰吾、鈴木伸明、兼松毅、鈴木奈瑠子、早川文彦、清井仁、小嶋哲人、松下正

    第46回日本血栓止血学会学術総会  2024.6.15 

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    Event date: 2024.6

    Language:Japanese  

  2. VWF欠損患者における血管新生能の異常

    岡本修一、鈴木伸明、田村彰吾、兼松毅、鈴木敦夫、鈴木奈瑠子、川口裕佳、清井仁、早川文彦、小嶋哲人、松下正

    第85回日本血液学会学術総会  2023.10.13 

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    Event date: 2023.10

    Presentation type:Oral presentation (general)  

  3. 患者由来endothelial colony forming cell (ECFC)を用いたVWF欠損状態における血管新生能の評価

    岡本修一、鈴木伸明、田村彰吾、鈴木敦夫、鈴木奈瑠子、清井仁、小嶋哲人、松下正、早川文彦

    第45回日本血栓止血学会学術総会  2023.6.15 

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    Event date: 2023.6

    Presentation type:Poster presentation  

  4. Multimerの経時的変化が止血効果の指標となった後天性von Willebrand症候群の1例

    岡本修一、鈴木伸明、兼松毅、鈴木敦夫、鈴木奈瑠子、清井仁、小嶋哲人、松下正

    第44回日本血栓止血学会学術総会  2022.6.24 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  5. Endothelial colony forming cells (ECFCs)の安定した樹立を 目指して

    岡本修一、鈴木伸明、兼松毅、鈴木敦夫、鈴木奈瑠子、田村彰吾、早川文彦、清井仁、松下正

    第70回日本輸血・細胞治療学会学術総会 

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    Event date: 2022.5

    Language:Japanese   Presentation type:Poster presentation  

  6. Multimer解析によるVWFの血中動態評価

    岡本修一、鈴木伸明、兼松毅、鈴木奈瑠子、鈴木敦夫、田村彰吾、清井仁、松下正

    第 60 回日本臨床検査医学会東海・北陸支部総会 第 344 回日本臨床化学会東海・北陸支部例会 連合大会  2022.3.5 

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    Event date: 2022.3

    Language:Japanese  

  7. p.G2752S severely affects dimerization of von Willebrand factor: an analysis of type 3 von Willebrand disease International conference

    S. Okamoto, S. Tamura, N. Suzuki, K. Odaira, Y. Hayakawa, A. Suzuki, T. Kanematsu, F. Hayakawa, H. Kiyoi, T. Kojima, T. Matsushita

    2021.7 

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    Event date: 2021.7

    Language:English   Presentation type:Poster presentation  

  8. VWF G2752S変異体の分子病態解析

    岡本修一、大平晃也、早川友梨、河島史華、田村彰吾、鈴木伸明、兼松毅、鈴木敦夫、早川文彦、清井仁、小嶋哲人、松下正

    第43回日本血栓止血学会 学術総会 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Poster presentation  

  9. 重症VWD症例で見出されたVWF G2752S 変異の分子病態

    岡本修一、大平晃也、早川友梨、河島史華、鈴木伸明、兼松毅、鈴木敦夫、田村彰吾、早川文彦、清井仁、小嶋哲人、松下正

    第82回日本血液学会 学術総会  2020.10 

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    Event date: 2020.10 - 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

  10. Low-factor consumption and cost effectiveness for surgeries in hemophilia B patients with N9-GP International conference

    S. Okamoto, T. Matsushita, T. Kanematsu, A. Suzuki, S. Tamura, T. Kojima, N. Suzuki

    ISTH 2020 Virtual Congress  2020.7 

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    Event date: 2020.7

    Language:English   Presentation type:Poster presentation  

  11. Investigation of a significant factor to improve an establishment of endothelial colony forming cell International conference

    S. Okamoto, N. Suzuki T. Kanematsu, A. Suzuki, K. Odaira, M. Tokoro, Y. Hayakawa, S. Tamura, F. Hayakawa, H. Kiyoi, T. Kojima, T. Matsushita

    ISTH 2020 Virtual Congress  2020.7 

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    Event date: 2020.7

    Language:English   Presentation type:Poster presentation  

  12. 周術期に中和療法からエミシズマブに切り替えて良好な経過を得た インヒビター保有血友病Aの一例

    岡本修一、鈴木伸明、鈴木幸子、田村彰吾、鈴木望人、高橋伸典、小嶋俊久、兼松毅、小島哲人、清井仁、石黒直樹、松下正

    第81回日本血液学会学術総会  2019.10.13 

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    Event date: 2019.10

    Language:Japanese   Presentation type:Poster presentation  

  13. Successful combination therapy with neutralization therapy and emicizumab in a patient with hemophilia A with inhibitors

    S.Okamoto, N.Suzuki, S.Suzuki, S.Tamura, A.Suzuki, T Kanematsu, T.Kojima, H.Kiyoi, T.Matsushita

    THE 8TH EAST ASIA HEMOPHILIA FORUM   2019.8.9 

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    Event date: 2019.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Tianjin, China  

  14. インヒビター保有先天性血友病Aに対するエミシズマブの投与経験

    岡本修一、鈴木伸明、兼松毅、田村彰吾、清井仁、小嶋哲人、葛西隆、松下正

    第41回日本血栓止血学会  2019.6.20 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  15. EBV陽性DLBCLの臨床的特徴の解析

    岡本修一、徳永隆之、 下地園子、 國富あかね、 宮田泰彦、飯田浩充、永井宏和

    第80回日本血液学会 学術総会  2018.10.14 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

  16. 再発・難治性マントルリンパ腫に対してイブルチニブを使用した2例

    岡本修一、宮田泰彦、下地園子、徳永隆之、國富あかね、 飯田浩充、永井宏和

    第71回国立病院 総合医学会  2017.11.11 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

  17. IMWGからの提言 Invited

    岡本修一、名倉英一

    第41回日本骨髄腫学会 学術総会  2016.5.28 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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Research Project for Joint Research, Competitive Funding, etc. 2

  1. Type3 VWD患者の血管新生能が難治性出血に及ぼす影響

    2022年度 (第31回) 堀科学芸術振興財団 研究助成事業 

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    Authorship:Principal investigator  Grant type:Competitive

  2. Type3 VWDにおける微量のVWF発現が VWFインヒビター発生に及ぼす影響

    一般財団法人 愛知健康増進財団  2022年度 医学研究・健康増進活動等助成 

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    Authorship:Principal investigator  Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. 「微量のVWF発現の有無」がVWFインヒビター発生に及ぼす影響

    2023.4 - 2026.3

    2023年度 若手研究

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    Authorship:Principal investigator  Grant type:Competitive

  2. ECFCにおけるV2 vasopressin receptorの局在・機能解析によるVWF分泌刺激機構の解 明

    2023.4 - 2026.3

    基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

 

Teaching Experience (On-campus) 4

  1. 医用工学及び実習

    2022

  2. 形態検査技術開発法II

    2022

  3. 血液検査学II

    2022

  4. 臨床病理学演習

    2022