Updated on 2025/04/04

写真a

 
ISHIZAKI Tomotaka
 
Organization
Nagoya University Hospital Neurosurgery Assistant professor of hospital
Title
Assistant professor of hospital
External link

Degree 2

  1. Doctor of Philosophy (Medical science) ( 2020.7   Nagoya University ) 

  2. Bachelor (Medical Doctor) ( 2011.3   Nagoya University ) 

Research Areas 1

  1. Life Science / Neurosurgery  / Epilepsy surgery

Current Research Project and SDGs 1

  1. Subcortical network revealed by stereotactic neurosurgery

Awards 2

  1. America Epilepsy Society 2019 Suzanne and Peter Berry International Travel Award

    2019.12   America Epilepsy Society  

    Tomotaka Ishizaki

     More details

    Award type:Award from international society, conference, symposium, etc.  Country:United States

  2. 2019 Japanese Epilepsy Society Sponsored Award UCB & Otsuka Award

    2019.3   Japan Epilepsy Society  

    Tomotaka Ishizaki

     More details

    Country:Japan

 

Papers 28

  1. Long-term outcome of a treat-to-target strategy in late-onset rheumatoid arthritis with chronic lung disease: 5-year results of a prospective observational study Open Access

    Nomura M., Sugihara T., Baba H., Hosoya T., Kamiya M., Ishizaki T., Matsumoto T., Kubo K., Hirano F., Kojima M., Miyasaka N., Yasuda S., Harigai M.

    Arthritis Research and Therapy   Vol. 27 ( 1 )   2025.12

     More details

    Publisher:Arthritis Research and Therapy  

    Background: Controlling disease activity and improving physical function would be more difficult in patients with late-onset rheumatoid arthritis (LORA) who have chronic lung disease (CLD) at baseline. Our aim was to evaluate 5-year outcomes of following a treat-to-target (T2T) strategy targeting low disease activity (LDA) in LORA with CLD. Methods: Data from 197 methotrexate (MTX)-naïve LORA patients (mean age 74.4 years) from a prospective, monocentric registry were analyzed. Patients were treated with MTX if they had one or more poor prognostic features. If they had interstitial lung disease (ILD), tacrolimus could be administered instead of MTX at the discretion of the attending physician. If patients exhibited no response according to the European League Against Rheumatism criteria at week 12 or had not achieved LDA by week 24, biological disease-modifying antirheumatic drugs (bDMARDs) were started targeting LDA. The primary outcomes were the 5-year simplified disease activity index (SDAI) remission and Health Assessment Questionnaire Disability Index (HAQ-DI) ≤ 0.5 by non-responder imputation analysis. Secondary outcomes were serious adverse events (SAEs). Results: Of the 197 LORA patients, 47 had CLD at baseline. The proportion of patients using MTX at baseline was significantly lower in those with than without CLD. Tacrolimus was initiated in 25.5% of the CLD group. The proportion of patients on bDMARDs was higher in those with CLD at year 5. Achievement of SDAI remission at year 5 was 29.8% in patients with CLD and 44.0% in those without CLD (p = 0.555). Achievement of HAQ-DI ≤ 0.5 at year 5 was 36.2% and 45.3% in patients with and without CLD, respectively (p = 0.939). Non-adherence to T2T due to comorbidities or adverse events was observed in 34.0% and 18.7% of the patients with and without CLD, respectively (p = 0.027). Infections requiring hospitalization, deterioration of extra-articular manifestations and fractures were more frequently reported as SAEs in patients with CLD, and multivariable analysis showed that patients with CLD had a higher risk of developing these SAEs (adjusted hazard ratio:2.53, 95% CI 1.60–4.00, p < 0.001). Conclusion: For LORA patients with CLD, the T2T strategy is effective, but comorbidities and SAEs make the implementation of the T2T more difficult.

    DOI: 10.1186/s13075-025-03491-1

    Open Access

    Scopus

  2. Thermal Diffusivity Measurements for High Thermal Conductive Materials by Applying Undersampling to Lock-in Thermography

    Kaneko, Y; Fujita, R; Ishizaki, T; Nagano, H

    INTERNATIONAL JOURNAL OF THERMOPHYSICS   Vol. 46 ( 4 )   2025.4

     More details

    Publisher:International Journal of Thermophysics  

    In this study, a method employing lock-in thermography is proposed for measuring the thermal diffusivity distribution of materials with high thermal conductivity. In this method, the thermal response distribution induced by periodic laser heating is analyzed, and the thermal diffusivity in the out-of-plane direction over the material surface is mapped. An undersampling method is applied during lock-in thermography to measure the thermal diffusivity distribution of materials with low thermal resistance at high frequencies. Additionally, a principle is developed to eliminate the inherent phase lag generated by the measurement system. The accuracy of the proposed method is validated by quantitatively measuring the thermal diffusivity of a pure copper sheet that exhibits an isotropic thermal diffusivity distribution. Results reveal that its average thermal diffusivity agreed with the reference value within + 2.4 %. The proposed method is also used to measure the thermal diffusivity of an isotropic graphite sheet with an inhomogeneous thermal diffusivity distribution. Results reveal that its average thermal diffusivity agreed with the reference value within + 7.0 %, and local areas with high thermal diffusivity are successfully visualized.

    DOI: 10.1007/s10765-025-03523-7

    Web of Science

    Scopus

  3. Frequency-specific network changes in mesial temporal lobe epilepsy: Analysis of chronic and transient dysfunctions in the temporo-amygdala-orbitofrontal network using magnetoencephalography Open Access

    Ishizaki, T; Maesawa, S; Suzuki, T; Hashida, M; Ito, Y; Yamamoto, H; Tanei, T; Natsume, J; Hoshiyama, M; Saito, R

    EPILEPSIA OPEN     2025.3

     More details

    Language:English   Publisher:Epilepsia Open  

    Objective: Mesial temporal lobe epilepsy (MTLE) is associated with disruptions in the temporo-amygdala-orbitofrontal (TAO) network, a key component of the limbic system. We aimed to investigate TAO network alterations in patients with MTLE using magnetoencephalography (MEG), which overcomes susceptibility artifacts that limit functional MRI analysis of the orbitofrontal cortex. Methods: Nine seizure-free patients with MTLE post-temporal lobectomy and nine age- and sex-matched healthy controls were recruited. Preoperative MEG data were collected and segmented into frequency bands ranging from delta to ripple to assess functional connectivity (FC) between the bilateral hippocampi and TAO network. Results: Patients with MTLE exhibited increased FC between the affected hippocampus and amygdala across all frequency bands. Additionally, FC between the affected hippocampus and the medial prefrontal cortex (mPFC), orbitofrontal gyrus (OFG), and amygdala was elevated in the gamma and ripple bands compared with healthy controls. Conversely, FC between the healthy hippocampus and mPFC decreased in the alpha and beta bands. Furthermore, FC within the TAO network fluctuated before and after epileptic spikes; there was a decrease in the delta band between the bilateral hippocampi and the amygdala, OFG, and thalamus, whereas FC between the hippocampus and mPFC increased in the alpha, beta, and ripple bands. Significance: These findings suggest the formation of an abnormal network involving the affected hippocampus and the TAO network, particularly in the gamma–ripple bands, indicating epilepsy-induced network disruptions. Reduced FC in the healthy hippocampus and the TAO network may reflect frontal lobe dysfunction related to emotion and cognition. Additionally, both chronic and transient FC changes observed via MEG may contribute to the cognitive and psychiatric impairments experienced by patients with MTLE. This study highlights the significance of frequency-specific network alterations in understanding MTLE's pathophysiology and its impact on limbic system functions. Plain language summary: In mesial temporal lobe epilepsy, there may be abnormal connectivity between the hippocampus and the limbic system, which is involved in memory, cognition, and emotion. The changes in connectivity observed using magnetoencephalography may be implicated in cognitive and psychiatric problems experienced by patients with mesial temporal lobe epilepsy. Examining disruptions in the connectivity across brain regions in relation to epileptic activity could further the understanding of the pathophysiology of this debilitating condition and its impact on behavioral and emotional functions, among others.

    DOI: 10.1002/epi4.70018

    Open Access

    Web of Science

    Scopus

    PubMed

  4. Comparison of Early-onset Efficacy of Anti-calcitonin Gene-related Peptide Monoclonal Antibodies for Patients with Migraine in Real-world Clinical Practice: Study Protocol for an Exploratory Clinical Trial Open Access

    TANEI Takafumi, MAESAWA Satoshi, NISHIMURA Yusuke, ISHIZAKI Tomotaka, NAGASHIMA Yoshitaka, HASHIDA Miki, YAMAMOTO Shun, ANDO Masahiko, KUWATSUKA Yachiyo, HASHIZUME Atsushi, WAKABAYASHI Toshihiko, SAITO Ryuta

    Neurologia medico-chirurgica   Vol. 65 ( 2 ) page: 71 - 80   2025.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japan Neurosurgical Society  

    <p>Three anti-calcitonin gene-related peptide monoclonal antibodies (CGRP-mAbs) are available in Japan: galcanezumab, fremanezumab, and erenumab. Early-onset efficacy has been demonstrated for each CGRP-mAb in comparison with placebo, but differences among the drugs are unclear. Only galcanezumab requires 2 doses at the initial injection. This study is a multicenter, open-label, randomized, two-group comparison trial, consisting of the random selection of a CGRP-mAb and 6 consecutive injections, and then discontinuation of the CGRP-mAb after 6 injections. The primary outcome is a comparison of early-onset efficacy between galcanezumab and both fremanezumab and erenumab after the initial injection. The secondary outcomes are comparisons between galcanezumab and both fremanezumab and erenumab, and between fremanezumab and erenumab as follows: weekly number of headache days, migraine days, and acute medication use are compared to baseline during one month after initial injection; time of subjectively perceiving onset of effect after initial injection; monthly changes in headache status from baseline to after third (3rd) injections; effective rates after initial and 3rd injections; improvement rates of depression scores between baseline and after 3rd injections; changes in number of absenteeism and presenteeism days in each month from baseline to after 3rd injections; proportion of ineffective cases after 3rd injections; recurrence rates and time to recurrence after CGRP-mAb discontinuation; effective rates of CGRP-mAb re-injections; detection of clinical factors associated with effectiveness after the initial and 3rd injections. The aim of this study is to investigate differences in early-onset efficacy among the CGRP-mAbs, and when and to what extent headache symptoms recur after discontinuation.</p>

    DOI: 10.2176/jns-nmc.2024-0201

    Open Access

    Web of Science

    Scopus

    PubMed

    CiNii Research

    researchmap

  5. Hemorrhagic complication due to vascular side branch injury from a distant site in stereoelectroencephalography: A case report and proposed rules for safer electrode implantation

    Suzuki, T; Ishizaki, T; Maesawa, S; Hashida, M; Ito, Y; Tanei, T; Saito, R

    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY   Vol. 125   page: 50 - 53   2025.2

     More details

    Language:English   Publisher:Seizure  

    DOI: 10.1016/j.seizure.2024.12.019

    Web of Science

    Scopus

    PubMed

  6. Evaluation of mild cognitive impairment in older patients with essential tremor. International journal

    Miki Hashida, Satoshi Maesawa, Satomi Mizuno, Sachiko Kato, Yoshiki Ito, Manabu Mutoh, Takahiro Suzuki, Tomotaka Ishizaki, Takafumi Tanei, Takashi Tsuboi, Masashi Suzuki, Daisuke Nakatsubo, Takahiko Tsugawa, Epifanio Bagarinao, Toshihiko Wakabayashi, Masahisa Katsuno, Ryuta Saito

    Parkinsonism & related disorders   Vol. 131   page: 107228 - 107228   2025.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    INTRODUCTION: Recent studies have reported that essential tremor (ET) presents with not only motor symptoms but also cognitive dysfunction. However, detailed pathological mechanisms remain unclear. Here, we evaluate the characteristics of cognitive changes in older patients. METHODS: Eighty-five patients aged 65 years or older with ET but without dementia were evaluated for cognitive function using the Addenbrooke Cognitive Examination Revised (ACE-R). The patients were compared with healthy controls (HCs), and the characteristics of cognitive dysfunction were examined. Age at onset and correlations with tremor severity were also investigated. Moreover, we performed resting-state network (RSNs) analysis in a subset of these patients, and the functional connectivity (FC) within the networks was compared with age-matched controls. RESULTS: Compared to HCs, older patients with ET showed a clear reduction in the total (p = 0.001), attention (p = 0.005), verbal fluency (p = 0.001), and memory (p = 0.001) ACE-R scores. Older-onset patients showed significant cognitive dysfunction compared with younger-onset patients. Verbal fluency correlated with tremor severity in the multiple regression analysis (p < 0.001). RSNs showed an increase in FC in the frontal lobes within the language network in patients with ET compared to HCs (p < 0.05, FWE-corrected). CONCLUSION: Older patients with ET showed obvious cognitive dysfunction compared to HCs, indicating that cognitive dysfunction varies by age of onset and correlates with tremor severity. The results of the RSNs analysis suggest that the pathological mechanism of cognitive dysfunction in ET patients involves network changes similar to those in the early stages of Alzheimer's disease.

    DOI: 10.1016/j.parkreldis.2024.107228

    Web of Science

    Scopus

    PubMed

    researchmap

  7. Favorable seizure and developmental outcomes without preoperative intracranial electroencephalography in pediatric patients following epilepsy surgery: A single epilepsy center retrospective study. International journal Open Access

    Taro Okumura, Naotaka Usui, Akihiko Kondo, Hiroshi Ogawa, Mitsuru Hashiguchi, Yosuke Kuromi, Tokito Yamaguchi, Hideyuki Otani, Katsumi Imai, Tomotaka Ishizaki, Takafumi Tanei, Satoshi Maesawa, Ryuta Saito

    Epilepsia     2024.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: At our institute, most pediatric patients undergo epilepsy surgery following a thorough presurgical evaluation without intracranial electroencephalography (EEG). We conducted an initial validation of our noninvasive presurgical strategy by assessing the seizure and developmental outcomes of 135 children. METHODS: All 135 pediatric patients were <15 years old, had undergone curative surgery, and were followed for at least 2 years postoperatively. Presurgical evaluations and postoperative seizure and developmental outcomes were investigated. Thorough noninvasive evaluation included 3-T magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET) in all patients. Intracranial EEG was mainly indicated for patients whose MRIs were negative or subtle. We defined Engel class I as favorable and Engel classes II-IV as unfavorable seizure outcomes. Intelligence quotient (IQ) and developmental quotient (DQ) before and 2 years after surgery were used to assess developmental/neuropsychological outcomes. RESULTS: MRI was positive in 130 of 135 patients (96.3%), including 39 of 40 with focal cortical dysplasia (FCD) type II and 30 of 33 with FCD type I. FDG-PET revealed concordant localizing findings in 119 of 132 patients (90.2%). Ictal single photon emission computed tomography provided concordant localizing information in 85 of 91 patients (93.4%). Intracranial EEG was performed in only 10 of 135 patients (7.4%). Ninety-seven of 135 patients (71.9%) were seizure-free 2 years after surgery. The final seizure-free rate was 99 of 135 (73.3%). Temporal lobe surgery predicted a favorable seizure outcome by multivariate analysis, whereas FCD type I and preoperative IQ/DQ < 70 predicted an unfavorable outcome. The mean IQ change was +1.3 points, and the mean DQ change was +1.0 points. Mean DQ significantly improved following extratemporal surgery (multivariate regression, p < .05), and mean DQ significantly decreased in patients with epileptic spasms (multivariate regression, p < .01). SIGNIFICANCE: Thorough noninvasive presurgical evaluation enables detection of subtle MRI lesions and curative epilepsy surgery without intracranial EEG in most patients, including those with FCD type II and type I, and leads to favorable seizure and developmental/neuropsychological outcomes.

    DOI: 10.1111/epi.18249

    Open Access

    Web of Science

    Scopus

    PubMed

    researchmap

  8. A multi-center, open-label, randomized clinical trial evaluating the preventive effect of perampanel on craniotomy-induced epileptogenesis in seizure-naive patients with supratentorial brain tumors: study protocol for a GRAMPAS trial Open Access

    Yamaguchi, J; Ohka, F; Motomura, K; Ishizaki, T; Nakahara, N; Fujitani, S; Nagatani, T; Ohno, M; Ando, M; Kuwatsuka, Y; Nishida, K; Saito, R

    TRIALS   Vol. 25 ( 1 ) page: 849   2024.12

     More details

    Language:English   Publisher:Trials  

    Background: Early seizures after craniotomy are significant perioperative complications that can adversely impact patient outcomes. Despite current guidelines advising against the routine use of antiseizure drugs for seizure after craniotomy prevention due to limited efficacy data, many clinicians continue prescribing them. This discrepancy highlights the need for robust evidence to guide clinical practice. This multi-center, randomized clinical trial was designed to investigate the efficacy of perampanel in preventing early seizures after craniotomy. Method: This multi-center, open-label, randomized clinical trial will be conducted across five hospitals in Nagoya, Japan, from February 2024 to December 2026. A total of 142 seizure-naive patients with supratentorial brain tumors will be recruited and randomized (1:1) into the treatment and control groups. The treatment group will receive 2 mg of perampanel starting 2 days preoperatively and continuing for 28 days postoperatively, while the control group will receive no antiseizure drugs. The primary outcome is the incidence of seizures within 28 days after craniotomy. Secondary outcomes are length of hospital and intensive care unit stays and postoperative complications. Discussion: This study addresses the critical need for evidence-based recommendations regarding antiseizure drug use for preventing early seizures after craniotomy. As the first multi-center, randomized trial evaluating perampanel’s efficacy in this setting, the findings may significantly influence clinical guidelines and perioperative practices. Trial registration: This trial was registered with the Japan Registry of Clinical Trials (approval number: jRCTs041230117) on December 18, 2023, a member of the Primary Registry Network of the World Health Organization’s International Clinical Trials Registry Platform.

    DOI: 10.1186/s13063-024-08693-7

    Open Access

    Web of Science

    Scopus

    PubMed

  9. Real-world clinical results of CGRP monoclonal antibody treatment for medication overuse headache of migraine without abrupt drug discontinuation and no hospitalization Open Access

    Tanei T., Fuse Y., Maesawa S., Nishimura Y., Ishizaki T., Nagashima Y., Mutoh M., Ito Y., Hashida M., Suzuki T., Yamamoto S., Wakabayashi T., Saito R.

    Heliyon   Vol. 10 ( 22 ) page: e40190   2024.11

     More details

    Language:English   Publisher:Heliyon  

    Background: Abrupt discontinuation of overused medications is standard treatment for medication overuse headache (MOH), but discontinuation is difficult to maintain. The aim was to evaluate the real-world clinical results of anti-calcitonin gene-related peptide monoclonal antibody (CGRP-mAb) treatment for migraine with MOH without abrupt drug discontinuation and no hospitalization. Methods: Data were collected before starting CGRP-mAb injections (baseline) and 1 month after each injection. The following items were compared between baseline and after the first, second, and third CGRP-mAb injections, monthly headache days (MHD), monthly migraine days (MMD), monthly acute medication use (AMU) days, monthly total amount of AMU tablets, headache impact test-6 (HIT-6), and the migraine-specific quality of life questionnaire (MSQ). Achieving reduction rates ≥50 % in the frequency of each headache and migraine was defined as a good response. Achieving reduction rates of both AMU days and tablets ≥50 % was defined as effective in reducing AMU. Results: This study included 33 patients with migraine with MOH. After the third CGRP-mAb injection, MHD and MMD were significantly decreased from median 30.0 to 9.5 days, and 10.0 to 1.5 days, respectively. In addition, monthly AMU days and tablets were significantly decreased from median 28.0 to 8.0 days, and 30.0 to 9.5 tablets, respectively. After the third CGRP-mAb injection, the good MHD and MMD responder rates were 75.0 % and 85.7 %, respectively. The rate of reducing AMU was 78.6 %. HIT-6 and MSQ scores decreased significantly from baseline to after each CGRP-mAb injection. Conclusions: When CGRP-mAb was administered to migraine with MOH, frequency of headache symptoms and AMU were reduced without abrupt drug discontinuation and no hospitalization.

    DOI: 10.1016/j.heliyon.2024.e40190

    Open Access

    Scopus

    PubMed

  10. Epileptic foci and networks in children with epilepsy after acute encephalopathy with biphasic seizures and late reduced diffusion Open Access

    Mitsumatsu, T; Ito, Y; Maki, Y; Yamamoto, H; Sawamura, F; Ishizaki, T; Maesawa, S; Bagarinao, E; Nakata, T; Kidokoro, H; Saito, R; Natsume, J

    BRAIN & DEVELOPMENT   Vol. 46 ( 9 ) page: 302 - 307   2024.10

     More details

    Language:English   Publisher:Brain and Development  

    Background: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) develops along with status epilepticus and widespread subcortical white matter edema. We aimed to evaluate the epileptic foci and networks in two patients with epilepsy after AESD using simultaneous electroencephalography and functional magnetic resonance imaging (EEG-fMRI). Methods: Statistically significant blood oxygen level-dependent (BOLD) responses related to interictal epileptiform discharges (IEDs) were analyzed using an event-related design of hemodynamic response functions with multiple peaks. Results: Patient 1 developed focal seizures at age 10 years, one year after AESD onset. Positive BOLD changes were observed in the bilateral frontotemporal lobes, left parietal lobe, and left insula. BOLD changes were also observed in the subcortical structures. Patient 2 developed epileptic spasms at age two years, one month after AESD onset. Following total corpus callosotomy (CC) at age three years, the epileptic spasms resolved, and neurodevelopmental improvement was observed. Before CC, positive BOLD changes were observed bilaterally in the frontotemporal lobes. BOLD changes were also observed in the subcortical structures. After CC, the positive BOLD changes were localized in the temporal lobe ipsilateral to the IEDs, and the negative BOLD changes were mainly in the cortex and subcortical structures of the hemisphere ipsilateral to IEDs. Conclusion: EEG-fMRI revealed multiple epileptic foci and extensive epileptic networks, including subcortical structures in two cases with post-AESD epilepsy. CC may be effective in disconnecting the bilaterally synchronous epileptic networks of epileptic spasms after AESD, and pre-and post-operative changes in EEG-fMRI may reflect improvements in epileptic symptoms.

    DOI: 10.1016/j.braindev.2024.07.003

    Open Access

    Web of Science

    Scopus

    PubMed

  11. Outcomes and Prognostic Factors of Magnetic Resonance-guided Focused Ultrasound Thalamotomy for Essential Tremor at 2-year Follow-up Open Access

    HASHIDA Miki, MAESAWA Satoshi, KATO Sachiko, NAKATSUBO Daisuke, TSUGAWA Takahiko, TORII Jun, TANEI Takafumi, ISHIZAKI Tomotaka, MUTOH Manabu, ITO Yoshiki, TSUBOI Takashi, MIZUNO Satomi, SUZUKI Masashi, WAKABAYASHI Toshihiko, KATSUNO Masahisa, SAITO Ryuta

    Neurologia medico-chirurgica   Vol. 64 ( 4 ) page: 137 - 146   2024.4

     More details

    Language:English   Publisher:The Japan Neurosurgical Society  

    <p>Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is an effective treatment for essential tremor (ET). However, its long-term outcomes and prognostic factors remain unclear. This study aimed to retrospectively investigate 38 patients with ET who underwent MRgFUS thalamotomy and were followed up for >2 years. The improvement in tremor was evaluated using the Clinical Rating Scale for Tremor (CRST). Adverse events were documented, and correlations with factors, such as skull density ratio (SDR), maximum mean temperature (T-max), and lesion size, were examined. Furthermore, the outcomes were compared between two groups, one that met the cutoff values, which was previously reported (preoperative CRST-B ≤ 25, T-max ≥ 52.5°C, anterior-posterior size of lesion ≥ 3.9 mm, superior-inferior [SI] size of lesion > 5.5 mm), and the other that did not. The improvement rate was 59.4% on average at the 2-year follow-up. Adverse events, such as numbness (15.8%), dysarthria (10.5%), and lower extremity weakness (2.6%), were observed even after 2 years, although these were mild. The factors correlated with tremor improvement were the T-max and SI size of the lesion (p < 0.05), whereas the SDR showed no significance. Patients who met the aforementioned cutoff values demonstrated a 69.8% improvement at the 2-year follow-up, whereas others showed a 43.6% improvement (p < 0.05). In conclusion, MRgFUS is effective even after 2 years. The higher the T-max and the larger the lesion size, the better the tremor control. Previously reported cutoff values clearly predict the 2-year prognosis, indicating the usefulness of MRgFUS.</p>

    DOI: 10.2176/jns-nmc.2023-0202

    Open Access

    Web of Science

    Scopus

    PubMed

    CiNii Research

    J-GLOBAL

    researchmap

  12. Cerebellar and thalamic connector hubs facilitate the involvement of visual and cognitive networks in essential tremor. International journal Open Access

    Epifanio Bagarinao, Satoshi Maesawa, Sachiko Kato, Manabu Mutoh, Yoshiki Ito, Tomotaka Ishizaki, Takafumi Tanei, Takashi Tsuboi, Masashi Suzuki, Hirohisa Watanabe, Minoru Hoshiyama, Haruo Isoda, Masahisa Katsuno, Gen Sobue, Ryuta Saito

    Parkinsonism & related disorders   Vol. 121   page: 106034 - 106034   2024.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    INTRODUCTION: Connector hubs are specialized brain regions that connect multiple brain networks and therefore have the potential to affect the functions of multiple systems. This study aims to examine the involvement of connector hub regions in essential tremor. METHODS: We examined whole-brain functional connectivity alterations across multiple brain networks in 27 patients with essential tremor and 27 age- and sex-matched healthy controls to identify affected hub regions using a network metric called functional connectivity overlap ratio estimated from resting-state functional MRI. We also evaluated the relationships of affected hubs with cognitive and tremor scores in all patients and with motor function improvement scores in 15 patients who underwent postoperative follow-up evaluations after focused ultrasound thalamotomy. RESULTS: We have identified affected connector hubs in the cerebellum and thalamus. Specifically, the dentate nucleus in the cerebellum and the dorsomedial thalamus exhibited more extensive connections with the sensorimotor network in patients. Moreover, the connections of the thalamic pulvinar with the visual network were also significantly widespread in the patient group. The connections of these connector hub regions with cognitive networks were negatively associated (FDR q < 0.05) with cognitive, tremor, and motor function improvement scores. CONCLUSION: In patients with essential tremor, connector hub regions within the cerebellum and thalamus exhibited widespread functional connections with sensorimotor and visual networks, leading to alternative pathways outside the classical tremor axis. Their connections with cognitive networks also affect patients' cognitive function.

    DOI: 10.1016/j.parkreldis.2024.106034

    Open Access

    Web of Science

    Scopus

    PubMed

    researchmap

  13. Characteristics of deceased subjects transported to a postmortem imaging center due to unusual death related to epilepsy. International journal Open Access

    Yoshiki Ito, Nobuhiro Hata, Satoshi Maesawa, Takafumi Tanei, Tomotaka Ishizaki, Manabu Mutoh, Miki Hashida, Yutaka Kobayashi, Ryuta Saito

    Epilepsia open   Vol. 9 ( 2 ) page: 592 - 601   2024.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Patients with epilepsy have high risk of experiencing uncommon causes of death. This study aimed to evaluate patients who underwent unusual deaths related to epilepsy and identify factors that may contribute to these deaths and may also include sudden unexpected death in epilepsy (SUDEP). METHODS: We analyzed 5291 cases in which a postmortem imaging (PMI) study was performed using plane CT, because of an unexplained death. A rapid troponin T assay was performed using peripheral blood samples. Clinical information including the cause of death suspected by the attending physician, body position, place of death, medical history, and antiseizure medications was evaluated. RESULTS: A total of 132 (2.6%) patients had an obvious history of epilepsy, while 5159 individuals had no history of epilepsy (97.4%). Cerebrovascular disease was the cause of death in 1.6% of patients in the group with epilepsy, and this was significantly lower than that in the non-epilepsy group. However, drowning was significantly higher (9.1% vs. 4.4%). Unspecified cause of death was significantly more frequent in the epilepsy group (78.0% vs. 57.8%). Furthermore, the proportion of patients who demonstrated elevation of troponin T levels without prior cardiac disease was significantly higher in the epilepsy group (37.9% vs. 31.1%). At discovery of death, prone position was dominant (30.3%), with deaths occurring most commonly in the bedroom (49.2%). No antiseizure medication had been prescribed in 12% of cases, while 29.5% of patients were taking multiple antiseizure medications. SIGNIFICANCE: The prevalence of epilepsy in individuals experiencing unusual death was higher than in the general population. Despite PMI studies, no definitive cause of death was identified in a significant proportion of cases. The high troponin T levels may be explained by long intervals between death and examination or by higher incidence of myocardial damage at the time of death. PLAIN LANGUAGE SUMMARY: This study investigated unusual deaths in epilepsy patients, analyzing 5291 postmortem imaging cases. The results showed that 132 cases (2.6%) had a clear history of epilepsy. In these cases, only 22% cases were explained after postmortem examination, which is less than in non-epilepsy group (42.2%). Cerebrovascular disease was less common in the epilepsy group, while drowning was more common. Elevated troponin T levels, which suggest possibility of myocardial damage or long intervals between death and examination, were also more frequent in the epilepsy group compared to non-epilepsy group.

    DOI: 10.1002/epi4.12891

    Open Access

    Web of Science

    Scopus

    PubMed

    researchmap

  14. Boltless nylon-suture technique for stereotactic electroencephalography as a safe, effective alternative when the anchor bolt is inappropriate. International journal

    Manabu Mutoh, Satoshi Maesawa, Daisuke Nakatsubo, Tomotaka Ishizaki, Takafumi Tanei, Jun Torii, Yoshiki Ito, Miki Hashida, Ryuta Saito

    Acta neurochirurgica   Vol. 166 ( 1 ) page: 18 - 18   2024.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: The use of anchor bolts to secure electrodes to the skull can be difficult in some clinical situations. Herein, we present the boltless technique to secure electrodes to the scalp using nylon sutures to overcome the problems associated with anchor bolts. We investigated the safety, accuracy errors, and patient-related and operative factors affecting errors in the boltless technique. METHODS: This single-institution retrospective series analyzed 103 electrodes placed in 12 patients. The target-point localization error (TPLE), entry-point localization error (EPLE), radial error (RE), and depth error (DE) of the electrodes were calculated. RESULTS: The median of the mean operative time per electrode was 9.3 min. The median TPLE, EPLE, RE, and absolute DE value were 4.1 mm, 1.6 mm, 2.7 mm, and 1.9 mm, respectively. Positive correlations were observed between the preoperative scalp thickness, mean operative time per electrode, EPLE, RE, and the absolute value of DE versus TPLE (r = .228, p = .02; r = .678, p = .015; r = .228, p = .02; r = .445, p < .01; r = .630, p < .01, respectively), and electrode approach angle versus EPLE (r = .213, p = .031). Multivariate analysis revealed that the absolute value of DE had the strongest influence on the TPLE, followed by RE and preoperative scalp thickness, respectively (β = .938, .544, .060, respectively, p < .001). No complications related to SEEG insertion and monitoring were encountered. CONCLUSION: The boltless technique using our unique planning and technical method is a safe, effective, and low-cost alternative in cases where anchor bolts are contraindicated.

    DOI: 10.1007/s00701-024-05889-3

    Web of Science

    Scopus

    PubMed

    researchmap

  15. Hemodynamic and electrophysiological responses of the human amygdala during face imitation-a study using functional MRI and intracranial EEG. International journal Open Access

    Tetsuya Iidaka, Satoshi Maesawa, Noriaki Kanayama, Makoto Miyakoshi, Tomotaka Ishizaki, Ryuta Saito

    Cerebral cortex (New York, N.Y. : 1991)   Vol. 34 ( 1 )   2024.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The involvement of the human amygdala in facial mimicry remains a matter of debate. We investigated neural activity in the human amygdala during a task in which an imitation task was separated in time from an observation task involving facial expressions. Neural activity in the amygdala was measured using functional magnetic resonance imaging in 18 healthy individuals and using intracranial electroencephalogram in six medically refractory patients with epilepsy. The results of functional magnetic resonance imaging experiment showed that mimicry of negative and positive expressions activated the amygdala more than mimicry of non-emotional facial movements. In intracranial electroencephalogram experiment and time-frequency analysis, emotion-related activity of the amygdala during mimicry was observed as a significant neural oscillation in the high gamma band range. Furthermore, spectral event analysis of individual trial intracranial electroencephalogram data revealed that sustained oscillation of gamma band activity originated from an increased number and longer duration of neural events in the amygdala. Based on these findings, we conclude that during facial mimicry, visual information of expressions and feedback from facial movements are combined in the amygdalar nuclei. Considering the time difference of information approaching the amygdala, responses to facial movements are likely to modulate rather than initiate affective processing in human participants.

    DOI: 10.1093/cercor/bhad488

    Open Access

    Web of Science

    Scopus

    PubMed

    researchmap

  16. Relief of Central Poststroke Pain Affecting Both the Arm and Leg on One Side by Double-independent Dual-lead Spinal Cord Stimulation Using Fast-acting Subperception Therapy Stimulation: A Case Report

    TANEI Takafumi, MAESAWA Satoshi, NISHIMURA Yusuke, NAGASHIMA Yoshitaka, ISHIZAKI Tomotaka, MUTOH Manabu, ITO Yoshiki, SAITO Ryuta

    NMC Case Report Journal   Vol. 10 ( 0 ) page: 15 - 20   2023.12

     More details

    Language:English   Publisher:The Japan Neurosurgical Society  

    <p>Central poststroke pain is a chronic, intractable, central neuropathic pain. Spinal cord stimulation is a neuromodulation therapy for chronic neuropathic pain. The conventional stimulation method induces a sense of paresthesia. Fast-acting subperception therapy is one of the latest new stimulation methods without paresthesia. A case of achieving pain relief of central poststroke pain affecting both the arm and leg on one side by double-independent dual-lead spinal cord stimulation using fast-acting subperception therapy stimulation is presented. A 67-year-old woman had central poststroke pain due to a right thalamic hemorrhage. The numerical rating scale scores of the left arm and leg were 6 and 7, respectively. Using dual-lead stimulation at the Th 9-11 levels, a spinal cord stimulation trial was performed. Fast-acting subperception therapy stimulation achieved pain reduction in the left leg from 7 to 3. Therefore, a pulse generator was implanted, and the pain relief continued for 6 months. Then, two additional leads were implanted at the C 3-5 levels, and pain in the arm decreased from 6 to 4. Independent setting and adjustments of the dual-lead stimulation were required because the thresholds of paresthesia perception were significantly different. To achieve pain relief in both the arm and leg, double-independent dual-lead stimulation placed at cervical and thoracic levels is an effective treatment. Fast-acting subperception therapy stimulation may be effective for central poststroke pain, especially in cases where the paresthesia is perceived as uncomfortable or the conventional stimulation itself is ineffective.</p>

    DOI: 10.2176/jns-nmc.2022-0336

    PubMed

    CiNii Research

    researchmap

  17. Epileptogenic zone in Broca's area is resectable under awake surgery in accordance with the hodotopic framework: A case report. International journal Open Access

    Takahiro Suzuki, Tomotaka Ishizaki, Satoshi Maesawa, Miki Hashida, Manabu Mutoh, Yoshiki Ito, Takafumi Tanei, Ryuta Saito

    Seizure   Vol. 112   page: 84 - 87   2023.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.seizure.2023.09.018

    Open Access

    Web of Science

    Scopus

    PubMed

    researchmap

  18. Microscale mapping of thermal contact resistance using lock-in thermography

    Ishizaki, T; Nagano, H

    INTERNATIONAL JOURNAL OF THERMAL SCIENCES   Vol. 193   2023.11

     More details

    Publisher:International Journal of Thermal Sciences  

    This paper proposes a new thermal contact resistance distribution measurement method using lock-in thermography. This method was used to evaluate a two-dimensional local thermal contact resistance distribution. To be able to measure the distribution, a uniform intensity laser heating system was developed. The developed system has a top-hat intensity distribution with a diameter of 30 mm. By combining this heat source and the lock-in thermography, a new measurement instrument was developed, which can evaluate local temperature behavior in the frequency domain, including the information of the contact interface in high spatial resolution of about 70 μm. Additionally, a new thermal contact resistance measurement principle was constructed based on a one-dimensional heat transfer equation that considers the reflected and transmitted temperature waves at the boundary and contact interface. The thermal contact resistance was acquired as a solution to the inverse problem of the temperature response done by fitting analyses. The validation of this method was performed quantitatively with two samples made of two bonded isotropic graphite plates. The one sample has an intentional defect area that has a slightly higher thermal resistance. The other sample has the known thermal contact resistance value measured with a validated method. Based on the results, the measurement value agreed with the referenced value. Also, the defect area was quantitatively detected clearly as a high thermal resistance region. Furthermore, as a practical example, the measurement method was applied for two different contact interface roughness samples consisting of aluminum alloys and thermal grease. Consequently, it was revealed and visualized that the contact interface with a rough surface has a high thermal resistance spot.

    DOI: 10.1016/j.ijthermalsci.2023.108475

    Web of Science

    Scopus

  19. Focus disconnection of the SEEG-identified-epileptic network by radiofrequency thermal coagulation International journal Open Access

    石崎友崇, 前澤聡, 前澤聡, 山本啓之, 山本啓之, 橋田美紀, 武藤学, 伊藤芳記, 種井隆文, 夏目淳, 夏目淳, 齋藤竜太, 齋藤竜太

    てんかん研究   Vol. 111 ( 2 ) page: 17 - 20   2023.10

  20. Efficacy of the latest new stimulation patterns of spinal cord stimulation for intractable neuropathic pain compared to conventional stimulation: study protocol for a clinical trial. International journal Open Access

    Takafumi Tanei, Satoshi Maesawa, Yusuke Nishimura, Yoshitaka Nagashima, Tomotaka Ishizaki, Masahiko Ando, Yachiyo Kuwatsuka, Atsushi Hashizume, Shimon Kurasawa, Ryuta Saito

    Trials   Vol. 24 ( 1 ) page: 604 - 604   2023.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Spinal cord stimulation (SCS) is one of the neuromodulation therapies for chronic neuropathic pain. The conventional paresthesia-based SCS involves the application of tonic stimulation that induces a sense of paresthesia. Recently, new SCS stimulation patterns without paresthesia have been developed. Differential target multiplexed (DTM) stimulation and fast-acting subperception therapy (FAST) stimulation are the latest paresthesia-free SCS patterns. METHODS: A single-center, open-label, crossover, randomized clinical trial to investigate the superiority of SCS using the latest new stimulation patterns over conventional tonic stimulation for neuropathic pain is planned. This study consists of two steps: SCS trial (first step) and SCS system implantation (second step). In the SCS trial, participants will be randomly assigned to 4 groups receiving stimulation, including tonic, DTM, and FAST. Each stimulation will then be performed for 2 days, and a visual analog scale (VAS) for pain will be evaluated before and after each stimulation pattern. A stimulation-off period for 1 day is set between each stimulation pattern to wash out the residual previous stimulation effects. Pain improvement is defined as more than 33% reduction in the pain VAS. The primary analysis will compare pain improvement between the new stimulation patterns and the conventional tonic stimulation pattern in the SCS trial. The secondary outcomes will be evaluated as follows: (1) the relationships between causative disease and improvement rate by each stimulation pattern; (2) comparison of pain improvement between the DTM and FAST stimulation patterns in all cases and by causative disease; (3) changes in assessment items preoperatively to 24 months after the implantation; (4) preoperative factors associated with long-term effects defined as continuing for more than 12 months; and (5) adverse events related to this study 3 months after the implantation. DISCUSSION: This study aims to clarify the effectiveness of the latest new stimulation patterns compared to the conventional tonic stimulation. In addition, which stimulation pattern is most effective for which kind of causative disease will be clarified. TRIAL REGISTRATION: Japan Registry of Clinical Trials (jRCT) 1,042,220,094. Registered on 21 November 2022, and last modified on 6 January 2023. jRCT is an approved member of the Primary Registry Network of WHO ICTRP.

    DOI: 10.1186/s13063-023-07637-x

    Open Access

    Web of Science

    Scopus

    PubMed

    researchmap

  21. Connectivity alteration in thalamic nuclei and default mode network-related area in memory processes in mesial temporal lobe epilepsy using magnetoencephalography. International journal Open Access

    Tomotaka Ishizaki, Satoshi Maesawa, Daisuke Nakatsubo, Hiroyuki Yamamoto, Jun Torii, Manabu Mutoh, Jun Natsume, Minoru Hoshiyama, Ryuta Saito

    Scientific reports   Vol. 13 ( 1 ) page: 10632 - 10632   2023.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    This work aimed to investigate the involvement of the thalamic nuclei in mesial temporal lobe epilepsy (MTLE) and identify the influence of interictal epileptic discharges on the neural basis of memory processing by evaluating the functional connectivity (FC) between the thalamic nuclei and default mode network-related area (DMNRA) using magnetoencephalography. Preoperative datasets of nine patients with MTLE with seizure-free status after surgery and those of nine healthy controls were analyzed. The FC between the thalamic nuclei (anterior nucleus [ANT], mediodorsal nucleus [MD], intralaminar nuclei [IL]), hippocampus, and DMNRA was examined for each of the resting, pre-spike, spike, and post-spike periods in the delta to ripple bands using magnetoencephalography. The FC between the ANT, MD, hippocampus, and medial prefrontal cortex increased in the gamma to ripple bands, whereas the FC between the ANT, IL, and DMNRA decreased in the delta to beta bands, compared with that of the healthy controls at rest. Compared with the rest period, the pre-spike period had significantly decreased FC between the ANT, MD, and DMNRA in the ripple band. Different FC changes between the thalamic nuclei, hippocampus, and DMNRA of specific connections in a particular band may reflect impairment or compensation in the memory processes.

    DOI: 10.1038/s41598-023-37834-2

    Open Access

    Web of Science

    Scopus

    PubMed

    researchmap

  22. Differential target multiplexed spinal cord stimulation using a paddle-type lead placed at the appropriate site for neuropathic pain after spinal cord injury in patients with past spinal surgical histories: study protocol for an exploratory clinical trial. International journal Open Access

    Takafumi Tanei, Satoshi Maesawa, Yusuke Nishimura, Yoshitaka Nagashima, Tomotaka Ishizaki, Masahiko Ando, Yachiyo Kuwatsuka, Atsushi Hashizume, Shimon Kurasawa, Ryuta Saito

    Trials   Vol. 24 ( 1 ) page: 395 - 395   2023.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Neuropathic pain after spinal cord injury (SCI), both traumatic and non-traumatic, is refractory to various treatments. Spinal cord stimulation (SCS) is one of the neuromodulation therapies for neuropathic pain, although SCS has insufficient efficacy for neuropathic pain after SCI. The reasons are presumed to be inappropriate locations of SCS leads and conventional tonic stimulation itself does not have a sufficient analgesic effect for the pain. In patients with past spinal surgical histories, the cylinder-type leads are likely to be placed on the caudal side of the SCI because of surgical adhesions. Differential target multiplexed (DTM) stimulation is one of the latest new stimulation patterns that is superior to conventional stimulation. METHODS: A single-center, open-label, randomized, two-way crossover trial is planned to investigate the efficacy of SCS using DTM stimulation placing a paddle lead at the appropriate site for neuropathic pain after SCI in patients with spinal surgical histories. The paddle-type lead delivers energy more efficiently than a cylinder-type lead. This study consists of two steps: SCS trial (first step) and SCS system implantation (second step). The primary outcome is rates of achieving pain improvement with more than 33% reduction 3 months after SCS system implantation. The secondary outcomes are to be evaluated as follows: (1) effectiveness of DTM and tonic stimulations during the SCS trial; (2) changes of assessment items from 1 to 24 months; (3) relationships between the result of the SCS trial and the effects 3 months after SCS system implantation; (4) preoperative factors associated with a long-term effect, defined as continuing for more than 12 months; and (5) whether gait function improves from 1 to 24 months. DISCUSSION: A paddle-type lead placed on the rostral side of SCI and using DTM stimulation may provide significant pain relief for patients with intractable neuropathic pain after SCI in patients with past spinal surgical histories. TRIAL REGISTRATION: Japan Registry of Clinical Trials (jRCT) jRCT 1042220093. Registered on 21 November 2022, and last modified on 6 January 2023. jRCT is approved as a member of the Primary Registry Network of WHO ICTRP.

    DOI: 10.1186/s13063-023-07433-7

    Open Access

    Web of Science

    Scopus

    PubMed

    researchmap

  23. Clinical Impacts of Stereotactic Electroencephalography on Epilepsy Surgery and Associated Issues in the Current Situation in Japan Open Access

    MAESAWA Satoshi, ISHIZAKI Tomotaka, MUTOH Manabu, ITO Yoshiki, TORII Jun, TANEI Takafumi, NAKATSUBO Daisuke, SAITO Ryuta

    Neurologia medico-chirurgica   Vol. 63 ( 5 ) page: 179 - 190   2023.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japan Neurosurgical Society  

    <p>Stereotactic electroencephalography (SEEG) is receiving increasing attention as a safe and effective technique in the invasive evaluation for epileptogenic zone (EZ) detection. The main clinical question is whether the use of SEEG truly improves outcomes. Herein, we compared outcomes in our patients after three types of intracranial EEG (iEEG): SEEG, the subdural electrode (SDE), and a combined method using depth and strip electrodes. We present here our preliminary results from two demonstrative cases. Several international reports from large epilepsy centers found the following clinical advantages of SEEG: 1) three-dimensional analysis of structures, including bilateral and multilobar structures; 2) low rate of complications; 3) less pneumoencephalopathy and less patient burden during postoperative course, which allows the initiation of video-EEG monitoring immediately after implantation and does not require resection to be performed in the same hospitalization; and 4) a higher rate of good seizure control after resection. In other words, SEEG more accurately identified the EZ than the SDE method. We obtained similar results in our preliminary experiences under limited conditions. In Japan, as of August 2022, dedicated electrodes and SEEG accessories have not been approved and the use of the robot arm is not widespread. The Japanese medical community is hopeful that these issues will soon be resolved and that the experience with SEEG in Japan will align with that of large epilepsy centers internationally.</p>

    DOI: 10.2176/jns-nmc.2022-0271

    Open Access

    Web of Science

    Scopus

    PubMed

    CiNii Research

    researchmap

  24. Seizure Semiology and Functional Anatomy in the Cerebral Cortex

    前澤聡, 石崎友崇, 齋藤竜太

    Neurological Surgery   Vol. 51 ( 1 ) page: 17 - 28   2023.1

     More details

    Language:Japanese  

    Understanding the semiology and underlying anatomy of each seizure is essential for epilepsy surgeons. According to the International League Against Epilepsy(ILAE)classification in 2017, seizure types are classified as focal, generalized, or unknown onset, all of which are further classified as motor or non-motor onset. Impairment of awareness is involved in consciousness systems(consisting of subcortical structures such as the thalamus and upper brain stem)and cortical structures(including the frontoparietal association cortices). Seizures with motor features are divided into elementary symptoms for which myoclonic, clonic, and tonic expressions reflect the somatotopy of the primary motor cortex; and integrated or gestural motor expression representing activation of the motor association cortex. A rostrocaudal gradient is demonstrated in hyperkinetic movements in frontal lobe epilepsy. Non-motor epileptic features should be understood together with auras, which correspond to focal aware seizures and hold crucial localizing semiologic values. The correlation between functional anatomy and seizure semiology is justified by invasive recordings such as stereotactic electroencephalography and subdural recordings, and also confirmed by seizure outcomes after resection of supposed epileptogenic zones. In addition to the conventional localization theory, it is necessary to consider the neural network theory for further recognition of the functionally anatomical basis in an incomprehensible demonstration of seizures.

    DOI: 10.11477/mf.1436204711

    PubMed

    CiNii Research

    J-GLOBAL

    researchmap

  25. Cutoff values for the best management strategy for magnetic resonance-guided focused ultrasound ablation for essential tremor. International journal

    Jun Torii, Satoshi Maesawa, Daisuke Nakatsubo, Takahiko Tsugawa, Sachiko Kato, Tomotaka Ishizaki, Sou Takai, Masashi Shibata, Toshihiko Wakabayashi, Takashi Tsuboi, Masashi Suzuki, Ryuta Saito

    Journal of neurosurgery   Vol. 138 ( 1 ) page: 38 - 49   2023.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: The efficacy of magnetic resonance-guided focused ultrasound (MRgFUS) ablation for essential tremor (ET) is well known; however, no prognostic factors have been established. The authors aimed to retrospectively investigate MRgFUS ablation outcomes and associated factors and to define the cutoff values for each prognostic factor. METHODS: Sixty-four Japanese patients who underwent unilateral ventral intermediate nucleus thalamotomy with MRgFUS for ET were included. Follow-up evaluations were performed at 1 week and 1, 3, 6, 12, and 24 months postoperatively. Tremor suppression was evaluated using the Clinical Rating Scale for Tremor (CRST), and adverse effects were recorded postoperatively. Outcome-associated factors were examined preoperatively, intraoperatively, and postoperatively using multivariate analyses. The cutoff values for the prognostic factors were calculated using receiver operating characteristics. RESULTS: Percentage improvements in the CRST scores of the affected upper limb were 82.4%, 72.2%, 68.6%, and 65.9% at 1, 3, 6, and 12 months, respectively. Preoperatively, a high skull density ratio (SDR) (p ≤ 0.047), low CRST part B score (used to assess tremors during several tasks) (cutoff value 25, p ≤ 0.041), and nonoccurrence of resting tremors (p = 0.027) were significantly associated with improved tremor control. An intraoperatively high maximum mean temperature (cutoff value 52.5°C, p ≤ 0.047), postoperatively large lesion (cutoff value 3.9 mm in the anterior-posterior direction, p ≤ 0.002; cutoff value 5.0-5.55 mm in the superior-inferior direction, p ≤ 0.026), and small transducer focus correction (p ≤ 0.015) were also associated with improved tremor control. No valid cutoff value was found for SDR. Adverse effects (limb weakness, sensory disturbance, ataxia/walking disturbance, dysgeusia, dysarthria, and facial swelling) occurred transiently and were associated with high SDR, high temperature, high number of sonication sessions, large lesion, and occurrence of resting tremor. Patients who developed leg weakness experienced greater percentage improvement in tremors at 3 months postoperatively than those who did not. CONCLUSIONS: MRgFUS ablation could be used to achieve good tremor control with acceptable adverse effects in Japanese patients with ET. The relatively low SDR in Asian ethnic groups as compared with that of Western populations makes treatment difficult; however, the cutoff values obtained in this study may be useful for achieving good treatment outcomes even in such patients. Clinical trial registration no.: UMIN000026952 (University Hospital Medical Information Network). ABBREVIATIONS: ACPC = anterior commissure-posterior commissure; AP = anterior to posterior; CRST = Clinical Rating Scale for Tremor; ET = essential tremor; MRgFUS = magnetic resonance-guided focused ultrasound; PC = posterior commissure; PSA = posterior subthalamic area; RL = right to left; ROC = receiver operating characteristic; SDR = skull density ratio; SI = superior to inferior; T2WI = T2-weighted imaging; VIM = ventral intermediate nucleus.

    DOI: 10.3171/2022.3.JNS212460

    Web of Science

    Scopus

    PubMed

    researchmap

  26. A case report: Dual-lead deep brain stimulation of the posterior subthalamic area and the thalamus was effective for Holmes tremor after unsuccessful focused ultrasound thalamotomy. International journal Open Access

    Satoshi Maesawa, Jun Torii, Daisuke Nakatsubo, Hiroshi Noda, Manabu Mutoh, Yoshiki Ito, Tomotaka Ishizaki, Takashi Tsuboi, Masashi Suzuki, Takafumi Tanei, Masahisa Katsuno, Ryuta Saito

    Frontiers in human neuroscience   Vol. 16   page: 1065459 - 1065459   2022.12

     More details

    Language:English  

    Holmes tremor is a symptomatic tremor that develops secondary to central nervous system disorders. Stereotactic neuromodulation is considered when the tremors are intractable. Targeting the ventral intermediate nucleus (Vim) is common; however, the outcome is often unsatisfactory, and the posterior subthalamic area (PSA) is expected as alternative target. In this study, we report the case of a patient with intractable Holmes tremor who underwent dual-lead deep brain stimulation (DBS) to stimulate multiple locations in the PSA and thalamus. The patient was a 77-year-old female who complained of severe tremor in her left upper extremity that developed one year after her right thalamic infarction. Vim-thalamotomy using focused ultrasound therapy (FUS) was initially performed but failed to control tremor. Subsequently, we performed DBS using two leads to stimulate four different structures. Accordingly, one lead was implanted with the aim of targeting the ventral oralis nucleus (Vo)/zona incerta (Zi), and the other with the aim of targeting the Vim/prelemniscal radiation (Raprl). Electrode stimulation revealed that Raprl and Zi had obvious effects. Postoperatively, the patient achieved good tremor control without any side effects, which was maintained for two years. Considering that she demonstrated resting, postural, and intention/action tremor, and Vim-thalamotomy by FUS was insufficient for tremor control, complicated pathogenesis was presumed in her symptoms including both the cerebellothalamic and the pallidothalamic pathways. Using the dual-lead DBS technique, we have more choices to adjust the stimulation at multiple sites, where different functional networks are connected. Intractable tremors, such as Holmes tremor, may have complicated pathology, therefore, modulating multiple pathological networks is necessary. We suggest that the dual-lead DBS (Vo/Raprl and Vim/Zi) presented here is safe, technically feasible, and possibly effective for the control of Holmes tremor.

    DOI: 10.3389/fnhum.2022.1065459

    Open Access

    Web of Science

    Scopus

    PubMed

    researchmap

  27. Magnetic resonance-guided focused ultrasound thalamotomy restored distinctive resting-state networks in patients with essential tremor. International journal

    Sachiko Kato, Satoshi Maesawa, Epifanio Bagarinao, Daisuke Nakatsubo, Takahiko Tsugawa, Satomi Mizuno, Kazuya Kawabata, Takashi Tsuboi, Masashi Suzuki, Masashi Shibata, Sou Takai, Tomotaka Ishizaki, Jun Torii, Manabu Mutoh, Ryuta Saito, Toshihiko Wakabayashi, Masahisa Katsuno, Norio Ozaki, Hirohisa Watanabe, Gen Sobue

    Journal of neurosurgery   Vol. 138 ( 2 ) page: 306 - 317   2022.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy ameliorates symptoms in patients with essential tremor (ET). How this treatment affects canonical brain networks has not been elucidated. The purpose of this study was to clarify changes of brain networks after MRgFUS thalamotomy in ET patients by analyzing resting-state networks (RSNs). METHODS: Fifteen patients with ET were included in this study. Left MRgFUS thalamotomy was performed in all cases, and MR images, including resting-state functional MRI (rsfMRI), were taken before and after surgery. MR images of 15 age- and sex-matched healthy controls (HCs) were also used for analysis. Using rsfMRI data, canonical RSNs were extracted by performing dual regression analysis, and the functional connectivity (FC) within respective networks was compared among pre-MRgFUS patients, post-MRgFUS patients, and HCs. The severity of tremor was evaluated using the Clinical Rating Scale for Tremor (CRST) score pre- and postoperatively, and its correlation with RSNs was examined. RESULTS: Preoperatively, ET patients showed a significant decrease in FC in the sensorimotor network (SMN), primary visual network (VN), and visuospatial network (VSN) compared with HCs. The decrease in FC in the SMN correlated with the severity of tremor. After MRgFUS thalamotomy, ET patients still exhibited a significant decrease in FC in a small area of the SMN, but they exhibited an increase in the cerebellar network (CN). In comparison between pre- and post-MRgFUS patients, the FC in the SMN and the VSN significantly increased after treatment. Quantitative evaluation of the FCs in these three groups showed that the SMN and VSN increased postoperatively and demonstrated a trend toward those of HCs. CONCLUSIONS: The SMN and CN, which are considered to be associated with the cerebello-thalamo-cortical loop, exhibited increased connectivity after MRgFUS thalamotomy. In addition, the FC of the visual network, which declined in ET patients compared with HCs, tended to normalize postoperatively. This could be related to the hypothesis that visual feedback is involved in tremor severity in ET patients. Overall, the analysis of the RSNs by rsfMRI reflected the pathophysiology with the intervention of MRgFUS thalamotomy in ET patients and demonstrated a possibility of a biomarker for successful treatment.

    DOI: 10.3171/2022.5.JNS22411

    Web of Science

    Scopus

    PubMed

    researchmap

  28. Multitier Network Analysis Using Resting-state Functional MRI for Epilepsy Surgery Open Access

    MAESAWA Satoshi, BAGARINAO Epifanio, NAKATSUBO Daisuke, ISHIZAKI Tomotaka, TAKAI Sou, TORII Jun, KATO Sachiko, SHIBATA Masashi, WAKABAYASHI Toshihiko, SAITO Ryuta

    Neurologia medico-chirurgica   Vol. 62 ( 1 ) page: 45 - 55   2022

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japan Neurosurgical Society  

    <p>Resting-state functional MRI (rs-fMRI) has been utilized to visualize large-scale brain networks. We evaluated the usefulness of multitier network analysis using rs-fMRI in patients with focal epilepsy. Structural and rs-fMRI data were retrospectively evaluated in 20 cases with medically refractory focal epilepsy, who subsequently underwent surgery. First, structural changes were examined using voxel-based morphometry analysis. Second, alterations in large-scale networks were evaluated using dual-regression analysis. Third, changes in cortical hubs were analyzed and the relationship between aberrant hubs and the epileptogenic zone (EZ) was evaluated. Finally, the relationship between the hubs and the default mode network (DMN) was examined using spectral dynamic causal modeling (spDCM). Dual-regression analysis revealed significant decrease in functional connectivity in several networks including DMN in patients, although no structural difference was seen between groups. Aberrant cortical hubs were observed in and around the EZ (EZ hubs) in 85% of the patients, and a strong degree of EZ hubs correlated to good seizure outcomes postoperatively. In spDCM analysis, facilitation was often seen from the EZ hub to the contralateral side, while inhibition was seen from the EZ hub to nodes of the DMN. Some cognition-related networks were impaired in patients with focal epilepsy. The EZ hub appeared in the vicinity of EZ facilitating connections to distant regions in the early phase, which may eventually generate secondary focus, while inhibiting connections to the DMN, which may cause cognitive deterioration. Our results demonstrate pathological network alterations in epilepsy and suggest that earlier surgical intervention may be more effective.</p>

    DOI: 10.2176/nmc.oa.2021-0173

    Open Access

    Web of Science

    Scopus

    PubMed

    CiNii Research

    researchmap

▼display all

Books 1

  1. Superhydrophobic Anticorrosion Coating

    Ishizaki T., Furukawa T., Kamiyama N., Saito N., Takai O.

    Handbook of Self-Cleaning Surfaces and Materials: From Fundamentals to Applications: Volumes 1 and 2  2023.1  ( ISBN:9783527690688, 9783527351367

     More details

    In this chapter, we introduce two types of superhydrophobic films formed on AZ31 magnesium alloy. One was fabricated by plasma chemical vapor deposition (CVD), and the other was prepared by two-step immersion processes. These film surfaces showed a static water contact angle of more than 150°. The hydrophobicity and root mean square roughness of the film surface increased with an increase in deposition or immersion time. The durability of these superhydrophobic surfaces in corrosive 5 wt% NaCl aqueous solution was elucidated. The anticorrosion resistance of these films was estimated by potentiodynamic polarization curve and electrochemical impedance spectroscopy (EIS) measurements. The EIS measurements and appropriate equivalent circuit models revealed that these superhydrophobic films considerably improved the anticorrosion-resistant performance of magnesium alloy AZ31. The anticorrosion mechanism of these superhydrophobic films was also proposed.

    DOI: 10.1002/9783527690688.ch28

    Scopus

MISC 45

  1. Functional connectivity profiles in the ventral anterior thalamus and centro-median nucleus in the thalamus

    水野聡美, 前澤聡, バガリナオ エピファニオ, 前澤聡, バガリナオ エピファニオ, 種井隆文, 石崎友崇, 武藤学, 伊藤芳記, 橋田美紀, 斎藤竜太, 斎藤竜太

    日本てんかん外科学会プログラム・抄録集   Vol. 47th   2024

  2. 高齢者の頚動脈プラークに対するFRACTURE MRIイメージングを用いた新規診断法の確立

    石崎友崇, 岡田健

    共済エグザミナー通信   ( 54 )   2024

  3. 脳磁図による内側側頭葉てんかんの海馬-前頭葉間周波数帯域別ネットワーク解析

    鈴木崇宏, 石崎友崇, 石崎友崇, 種井隆文, 山本啓之, 山本啓之, 武藤学, 伊藤芳記, 橋田美紀, 夏目淳, 夏目淳, 寳珠山稔, 前澤聡, 齋藤竜太, 齋藤竜太

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 26th   2024

  4. Reconsidering spinal cord stimulation for central post-stroke pain~Therapeutic effects of novel paresthesia-free stimulation~

    種井隆文, 前澤聡, 西村由介, 永島吉孝, 石崎友崇, 武藤学, 伊藤芳記, 橋田美紀, 齋藤竜太

    日本定位・機能神経外科学会プログラム・抄録集(Web)   Vol. 63rd   2024

  5. True feelings in surgery for mesial temporal lobe epilepsy: Is anterior temporal lobectomy better?

    前澤聡, 前澤聡, 石崎友崇, 武藤学, 伊藤芳記, 橋田美紀, 鈴木崇宏, 齋藤竜太

    日本てんかん外科学会プログラム・抄録集   Vol. 47th   2024

  6. 内側側頭葉てんかんにおけるhub解析

    前澤聡, 前澤聡, 前澤聡, エピファニオ バガリナオ, 石崎友崇, 武藤学, 伊藤芳記, 橋田美紀, 水野聡美, 水野聡美, 種井隆文, 藤原幸一, 齋藤竜太

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 26th   2024

  7. Limbic network changes by frequency bands in mesial temporal lobe epilepsy

    石崎友崇, 石崎友崇, 前澤聡, 山本啓之, 山本啓之, 種井隆文, 武藤学, 伊藤芳記, 橋田美紀, 鈴木崇宏, 夏目淳, 夏目淳, 寳子山稔, 齋藤竜太, 齋藤竜太

    日本てんかん外科学会プログラム・抄録集   Vol. 47th   2024

  8. Planning and boltless technique for safer and more stable SEEG with further improvements and challenges

    石崎友崇, 前澤聡, 山本啓之, 石崎友崇, 前澤聡, 山本啓之, 種井隆文, 武藤学, 伊藤芳記, 橋田美紀, 鈴木崇宏, 夏目淳, 齋藤竜太, 夏目淳, 齋藤竜太

    日本てんかん外科学会プログラム・抄録集   Vol. 47th   2024

  9. Network alternation and modulation in the thalamus and cerebellum in patients with essential tremor

    前澤聡, 前澤聡, 前澤聡, バガリナオ エピファニオ, 加藤幸子, 中坪大輔, 津川隆彦, 石崎友崇, 伊藤芳記, 武藤学, 水野聡美, 橋田美紀, 齋藤竜太

    日本定位・機能神経外科学会プログラム・抄録集(Web)   Vol. 63rd   2024

  10. 本態性振戦患者における高次脳機能障害の検討

    水野聡美, 前澤聡, 前澤聡, 前澤聡, 橋田美紀, エピファニオ バガリナオ, エピファニオ バガリナオ, 種井隆文, 石崎友崇, 武藤学, 伊藤芳記, 齋藤竜太, 齋藤竜太

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 26th   2024

  11. Evaluation of brain cognitive dysfunction in patients with essential tremor

    橋田美紀, 前澤聡, 前澤聡, 水野聡美, 中坪大輔, 津川隆彦, 加藤祥子, 種井隆文, 石崎友崇, 武藤学, 伊藤芳記, 鈴木崇宏, 若林俊彦, 若林俊彦, 齋藤竜太, 齋藤竜太

    日本定位・機能神経外科学会プログラム・抄録集(Web)   Vol. 63rd   2024

  12. Comparison of targeting between intraoperative microelectrode recording and anatomical auto-identification by Elements

    伊藤芳記, 前澤聡, 中坪大輔, 野田寛, 種井隆文, 石崎友崇, 鳥居潤, 武藤学, 齋藤竜太

    日本定位・機能神経外科学会プログラム・抄録集(Web)   Vol. 62nd   2023

  13. 術中微小電極記録(MER)は必要か?-MERによる標的部位決定とElementsによる同定との比較

    伊藤芳記, 前澤聡, 中坪大輔, 野田寛, 種井隆文, 石崎友崇, 鳥居潤, 武藤学, 齋藤竜太

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 25th   2023

  14. 視床前核(VA核)と機能的ネットワークの加齢変化

    水野聡美, 前澤聡, 前澤聡, バガリナオ エピファニオ, バガリナオ エピファニオ, 種井隆文, 石崎友崇, 武藤学, 伊藤芳記, 勝野雅央, 勝野雅央, 齋藤竜太, 齋藤竜太

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 25th   2023

  15. 視床腹側中間核(VIM核)と機能ネットワークの加齢変化

    水野聡美, 前澤聡, 前澤聡, バガリナオ エピファニオ, バガリナオ エピファニオ, 種井隆文, 石崎友崇, 武藤学, 伊藤芳記, 中坪大輔, 加藤祥子, 鳥居潤, 勝野雅央, 勝野雅央, 齋藤竜太, 齋藤竜太

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 25th   2023

  16. 難治性Holmes振戦に対し,dual lead DBSで振戦が軽減された1例

    鳥居潤, 前澤聡, 中坪大輔, 野田寛, 種井隆文, 石崎友崇, 武藤学, 伊藤芳記, 齋藤竜太

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 25th   2023

  17. Connectivity alteration between hippocampus and frontal lobe in mesial temporal lobe epilepsy using magnetoencephalography

    石崎友崇, 前澤聡, 前澤聡, 橋田美紀, 武藤学, 伊藤芳記, 種井隆文, 山本啓之, 山本啓之, 夏目淳, 夏目淳, 寳子山稔, 齋藤竜太, 齋藤竜太

    てんかん研究   Vol. 41 ( 2 )   2023

  18. 9軸モーションセンサを用いた本態性振戦およびジストニア性振戦の特徴抽出

    坪井崇, 澤田桂都, 星野聖奈, 樋口萌花, 武藤学, 伊藤芳記, 石崎友崇, 種井隆文, 中坪大輔, 前澤聡, 鈴木将史, 佐藤茉紀, 玉腰大悟, 平賀経太, 佐竹勇紀, 齋藤竜太, 勝野雅央

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 25th   2023

  19. MRガイド下集束超音波治療による本態性振戦患者の特徴的な安静時ネットワークの改善

    加藤祥子, 前澤聡, 前澤聡, バガリナオ エピファニオ, バガリナオ エピファニオ, 中坪大輔, 津川隆彦, 水野聡美, 川畑和也, 川畑和也, 坪井崇, 鈴木将史, 柴田昌志, 高井想生, 石崎友崇, 鳥居潤, 武藤学, 齋藤竜太, 若林俊彦, 若林俊彦, 勝野雅央, 尾崎紀夫, 渡辺宏久, 祖父江元

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 25th   2023

  20. SEEG identification of epileptic connectome and feasibility of stereotactic radiofrequency thermocoarulation for disconnection

    石崎友崇, 前澤聡, 前澤聡, 山本啓之, 山本啓之, 種井隆文, 武藤学, 伊藤芳記, 夏目淳, 夏目淳, 齋藤竜太, 齋藤竜太

    日本定位・機能神経外科学会プログラム・抄録集(Web)   Vol. 62nd   2023

  21. SEEG identification of epileptic connectome and feasibility of stereotactic radiofrequency thermocoagulation for disconnection

    石崎友崇, 前澤聡, 前澤聡, 山本啓之, 山本啓之, 種井隆文, 武藤学, 伊藤芳記, 夏目淳, 夏目淳, 齋藤竜太, 齋藤竜太

    日本てんかん外科学会プログラム・抄録集   Vol. 46th   2023

  22. SEEGによるてんかんコネクトームの同定と定位的ラジオ波温熱凝固術によるてんかん焦点離断術の可能性

    石崎友崇, 前澤聡, 前澤聡, 山本啓之, 山本啓之, 種井隆文, 武藤学, 伊藤芳記, 夏目淳, 夏目淳, 齋藤竜太, 齋藤竜太

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 25th   2023

  23. Clinical Impacts of Stereotactic Electroencephalography on Resection Surgery Following Focus Detection and Pitfalls

    前澤聡, 石崎友崇, 武藤学, 伊藤芳記, 鳥居潤, 種井隆文, 中坪大輔, 齋藤竜太

    日本てんかん外科学会プログラム・抄録集   Vol. 46th   2023

  24. SEEGはてんかん外科を変えるか?-6年間の臨床経験からの検討

    前澤聡, 石崎友崇, 種井隆文, 武藤学, 伊藤芳記, 橋田美紀, 齋藤竜太

    臨床神経生理学(Web)   Vol. 51 ( 5 )   2023

  25. Evaluation of seizure outcome in temporal lobe epilepsy using intraoperative electrocorticography

    石崎友崇, 前澤聡, 前澤聡, 山本啓之, 山本啓之, 種井隆文, 武藤学, 伊藤芳記, 夏目淳, 夏目淳, 齋藤竜太, 齋藤竜太

    日本てんかん外科学会プログラム・抄録集   Vol. 46th   2023

  26. The connectome profiles of the thalamus in patients with frontal and temporal epilepsy

    武藤学, 前澤聡, EPIFANIO Bagarinao, 中坪大輔, 種井隆文, 石崎友崇, 鳥居潤, 加藤祥子, 柴田昌志, 高井想生, 伊藤芳記, 齋藤竜太

    日本てんかん外科学会プログラム・抄録集   Vol. 46th   2023

  27. 前頭葉および側頭葉てんかんの視床コネクトームプロファイルの特徴

    武藤学, 前澤聡, 前澤聡, BAGARINAO Epifanio, 中坪大輔, 種井隆文, 石崎友崇, 鳥居潤, 加藤祥子, 柴田昌志, 高井想生, 伊藤芳記, 齋藤竜太

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 25th   2023

  28. 外視鏡・内視鏡併用contralateral anterior interhemispheric transcallosal approachが有用であった視床神経節膠腫の一例

    遠藤乙音, 石崎友崇, 藤井健太郎, 和田健太郎, 大野貴都, 黒野嵩矢, 板垣由宇也, 岡田健

    日本脳腫瘍の外科学会プログラム・抄録集   Vol. 28th   2023

  29. 定位機能外科手術におけるロボットアームの有用性

    前澤聡, 前澤聡, 石崎友崇, 中坪大輔, 武藤学, 伊藤芳記, 種井隆文, 齋藤竜太

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 25th   2023

  30. Functional localization of consciousness (awareness) and characteristics for associated networks in epilepsy patients

    前澤聡, 前澤聡, BAGARINAO Epifanio, 武藤学, 石崎友崇, 伊藤芳記, 種井隆文, 齊藤竜太

    日本てんかん外科学会プログラム・抄録集   Vol. 46th   2023

  31. 本態性振戦に対するMRガイド下集束超音波治療の長期成績と予後に影響する因子の検討

    加藤祥子, 前澤聡, 前澤聡, 中坪大輔, 津川隆彦, 若林俊彦, 若林俊彦, 伊藤芳記, 武藤学, 鳥居潤, 石崎友崇, 種井隆文, 齋藤竜太

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 17th   2023

  32. Spinal cord stimulation for neuropathic pains: Potential of paresthesia-free new stimulation methods

    種井隆文, 前澤聡, 西村由介, 永島孝吉, 石崎友崇, 武藤学, 伊藤芳記, 齋藤竜太

    機能的脳神経外科   Vol. 62   2023

  33. Spinal cord stimulation for neuropathic pains~Potential of paresthesia-free new stimulation methods~

    種井隆文, 前澤聡, 西村由介, 永島吉孝, 石崎友崇, 武藤学, 伊藤芳記, 齋藤竜太

    日本定位・機能神経外科学会プログラム・抄録集(Web)   Vol. 62nd   2023

  34. 神経障害性疼痛に対する脊髄刺激療法~Paresthesia-freeである新規刺激の可能性~

    種井隆文, 前澤聡, 西村由介, 永島吉孝, 石崎友崇, 武藤学, 伊藤芳記, 齋藤竜太

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 25th   2023

  35. Epilepsy surgery based on evaluation of epileptogenic zone using intraoperative electrocorticography

    石崎友崇, 前澤聡, 前澤聡, 山本啓之, 山本啓之, 鳥居潤, 武藤学, 伊藤芳記, 夏目淳, 夏目淳, 寳珠山稔, 齋藤竜太

    てんかん研究   Vol. 40 ( 2 )   2022

  36. 脳磁図による焦点てんかんの異常脳内ネットワークの評価と高次脳機能障害発症機構の解明

    石崎友崇

    てんかん治療研究振興財団研究年報   Vol. 33   2022

  37. Clinical features in SEEG or ECoG with subdural electrodes-consideration from our 5 year - clinical experiences

    前澤聡, 前澤聡, 中坪大輔, 中坪大輔, 石崎友崇, 石崎友崇, 鳥居潤, 武藤学, 加藤祥子, 加藤祥子, 高井想生, 柴田昌志, 柴田昌志, 齋藤竜太

    日本てんかん外科学会プログラム・抄録集   Vol. 45th   2022

  38. SEEGと硬膜下電極による頭蓋内脳波記録の臨床的特徴と今後の課題

    武藤学, 前澤聡, 中坪大輔, 石崎友崇, 鳥居潤, 加藤祥子, 柴田昌志, 高井想生, 齋藤竜太

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 24th   2022

  39. Therapeutic Strategies for Frontal Lobe Epilepsy in the SEEG Era

    鳥居潤, 前澤聡, 中坪大輔, 中坪大輔, 武藤学, 石崎友崇, 齋藤竜太

    日本てんかん外科学会プログラム・抄録集   Vol. 45th   2022

  40. てんかん てんかん外科の現状と展望

    前澤聡, 石崎友崇, 齋藤竜太

    現代醫學(Web)   Vol. 69 ( 2 )   2022

  41. 内側側頭葉てんかんの記憶障害に関与する視床核-DMN間ネットワーク障害の脳磁図による検討

    石崎友崇, 前澤聡, 前澤聡, 中坪大輔, 中坪大輔, 山本啓之, 鳥居潤, 夏目淳, 寳珠山稔, 齋藤竜太

    日本ヒト脳機能マッピング学会プログラム・抄録集   Vol. 24th   2022

  42. The connectome profiles of the thalamus in patients with frontal and temporal epilepsy

    武藤学, 前澤聡, 前澤聡, BAGARINAO Epifanio, 中坪大輔, 種井隆文, 石崎友崇, 鳥居潤, 加藤祥子, 柴川昌志, 高井想生, 伊藤芳記, 齋藤竜太

    てんかん研究   Vol. 40 ( 2 )   2022

  43. The road to facility certification of awake surgery and ingenuity of monitoring and mapping at a non-academic regional core hospital

    遠藤乙音, 石崎友崇, 藤井健太郎, 大野貴都, 岡田健, 有馬一, 竹内直子, 柳町ちひろ, 平野法子, 井上このみ, 佐久間一輝

    日本Awake Surgery学会プログラム・抄録集   Vol. 20th   2022

  44. Consideration for cognitive function and resting-state networks in patients with essential tremor

    前澤聡, 前澤聡, EPIFANIO Bagarinao, 中坪大輔, 中坪大輔, 津川隆彦, 加藤祥子, 水野聡美, 柴田昌志, 鳥居潤, 武藤学, 石崎友崇, 高井想生, 若林俊彦, 齋藤竜太

    日本定位・機能神経外科学会プログラム・抄録集(Web)   Vol. 61st   2022

  45. Experience and treatment of stroke associated epilepsy-Subarachnoid hemorrhage (SAH) and arteriovenous malformation (AVM)-

    遠藤乙音, 石崎友崇, 藤井健太郎, 岡田健

    てんかん研究   Vol. 40 ( 2 )   2022

▼display all