Updated on 2023/04/18


ITO Eiji
Nagoya University Hospital Neurosurgery Lecturer
Graduate School
Graduate School of Medicine

Degree 1

  1. 医学博士 ( 2010.7   名古屋大学 ) 

Research Areas 1

  1. Life Science / Neurosurgery


Papers 2

  1. Eyelid myokymia caused by a trigeminal schwannoma as determined by the trigeminal-evoked blink reflex.

    Ito E, Sugita R, Saito R

    Clinical case reports   Vol. 11 ( 3 ) page: e7086   2023.3

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    DOI: 10.1002/ccr3.7086


  2. Increased cerebrospinal fluid S100B protein levels in patients with trigeminal neuralgia and hemifacial spasm

    Ito Eiji, Seki Yukio, Saito Kiyoshi, Saito Ryuta


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    Language:English   Publisher:Acta Neurochirurgica  

    Background: The pathophysiology of neurovascular compression syndrome has not been fully elucidated, and cerebrospinal fluid levels of nerve tissue-related markers involved in this disorder have not yet been reported. Methods: We measured cerebrospinal fluid levels of S100B protein, neuron-specific enolase, and myelin basic protein in 21 patients with trigeminal neuralgia, 9 patients with hemifacial spasms, and 10 patients with non-ruptured intracranial aneurysms (control). Cerebrospinal fluid levels of these markers were determined using commercially available assay kits. Results: Both trigeminal neuralgia and hemifacial spasm groups showed significantly increased cerebrospinal fluid levels of S100B compared with the control group (1120 [IQR 391–1420], 766 [IQR 583–1500], and 255 [IQR 190–285] pg/mL, respectively; p = 0.001). There were no statistically significant differences in cerebrospinal fluid levels of neuron-specific enolase or myelin basic protein among the groups. Conclusion: Cerebrospinal fluid S100B levels were significantly higher in patients with trigeminal neuralgia and hemifacial spasm than in controls, which suggests the involvement of S100B in the underlying pathophysiology of neurovascular compression syndrome.

    DOI: 10.1007/s00701-022-05434-0

    Web of Science