2022/05/18 更新

写真a

イイジマ ヒロタカ
飯島 弘貴
IIJIMA Hirotaka
所属
高等研究院 特任助教
大学院医学系研究科 特任助教
職名
特任助教

学位 2

  1. 修士(人間健康科学) ( 2014年3月   京都大学 ) 

  2. 博士(人間健康科学) ( 2017年3月   京都大学 ) 

研究キーワード 4

  1. システム生物学

  2. メカノバイオロジー

  3. 加齢

  4. リハビリテーション

研究分野 4

  1. ライフサイエンス / 整形外科学

  2. ライフサイエンス / 生体医工学

  3. ライフサイエンス / 分子生物学

  4. ライフサイエンス / リハビリテーション科学

現在の研究課題とSDGs 3

  1. マルチセンサの有機的統合による革新的な運動機能評価システムの構築

  2. 新学際領域 Rejuvenative Rehabilitationの創出

  3. 加齢性疾患をドライブするエピジェネティクス制御機構の探求

経歴 6

  1. 名古屋大学   高等研究院 / 医学系研究科   助教

    2022年4月 - 現在

      詳細を見る

    国名:日本国

  2. University of Pittsburgh   School of Medicine, Physical Medicine and Rehabilitation (Paid Visiting Scholar, The Uehara Memorial Foundation))   研究員

    2021年4月 - 2022年3月

  3. 慶應義塾大学   理工学部システムデザイン工学科(訪問研究員)   研究員

    2019年5月 - 2022年3月

  4. University of Pittsburgh   School of Medicine, Physical Medicine and Rehabilitation (Visiting Scholar, JSPS Overse Research Fellow)   研究員

    2019年5月 - 2021年3月

  5. 京都大学   医学研究科人間健康科学系専攻(客員研究員)   研究員

    2017年4月 - 2021年3月

  6. 慶應義塾大学   理工学部システムデザイン工学科(JSPS特別研究員PD)   研究員

    2017年4月 - 2019年4月

▼全件表示

所属学協会 5

  1. 公益社団法人 日本理学療法士協会

  2. 日本軟骨代謝学会

  3. Osteoarthritis Research Society International (OARSI)

  4. 一般社団法人 日本機械学会

  5. American PHysiological Society

受賞 6

  1. リサーチフェローシップ事業

    2021年4月   上原記念生命科学財団  

  2. Young Investigator Award Osteoarthritis Research Society International

    2020年5月  

  3. Travel Award for 8th International Symposium on Regenerative Rehabilitation Alliance for Regenerative Rehabilitation Research and Training

    2019年10月  

  4. 日本長寿科学振興財団国際学会派遣事業 公益財団法人長寿科学振興財団

    2018年4月  

  5. 1st Author 日本骨代謝学会

    2017年3月  

  6. Outstanding Contribution in Reviewing Journal - Osteoarthritis Cartilage Elsevier

    2016年  

▼全件表示

 

論文 83

  1. Meta-analysis integrated with multi-omics data analysis to elucidate pathogenic mechanisms of age-related knee osteoarthritis in mice. 国際誌

    Iijima H, Gilmer G, Wang K, Sivakumar S, Evans C, Matsui Y, Ambrosio F

    The journals of gerontology. Series A, Biological sciences and medical sciences     2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/gerona/glab386

    Web of Science

    PubMed

  2. Rate of force development in the quadriceps of individuals with severe knee osteoarthritis: A preliminary cross-sectional study. 国際誌

    Suzuki Y, Iijima H, Nakamura M, Aoyama T

    PloS one   17 巻 ( 1 ) 頁: e0262508   2022年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PLoS ONE  

    Knee osteoarthritis (KOA) is a leading cause of knee pain and disability due to irreversible cartilage degeneration. Previous studies have not identified modifiable risk factors for KOA. In this preliminary cross-sectional study, we aimed to test the following hypotheses: individuals with severe KOA would have a significantly lower quadriceps rate of force development (RFD) than individuals with early KOA, and the decrease in quadriceps RFD would be greater than the decrease in maximum quadriceps strength in individuals with severe KOA. The maximum isometric strength of the quadriceps was assessed in individuals with mild (Kellgren and Lawrence [K&L] grade 1–2) and severe KOA (K&L grade 3–4) using a handheld dynamometer. The RFD was analyzed at 200 ms from torque onset and normalized to the body mass and maximum voluntary isometric contraction torque. To test whether the quadriceps RFD was lowered and whether the lower in the quadriceps RFD was greater than the lower in maximum quadriceps strength in individuals with severe knee OA, the Mann–Whitney U-test and analysis of covariance were performed, respectively. The effect size (ES) based on Hedges’ g with a 95% confidence interval (CI) was calculated for the quadriceps RFD and maximum quadriceps strength. Sixty-six participants were analyzed. Individuals with severe KOA displayed significantly lower quadriceps RFD (p = 0.009), the lower being greater than the lower in maximum quadriceps strength (between-group difference, ES: 0.88, -1.07 vs. 0.06, -0.22). Our results suggest that a decreased quadriceps RFD is a modifiable risk factor for progressive KOA. Our finding could help in the early detection and prevention of severe KOA.

    DOI: 10.1371/journal.pone.0262508

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    PubMed

  3. Increased recurrent falls experience in older adults with coexisting of sarcopenia and knee osteoarthritis: a cross-sectional study. 国際誌

    Hirotaka Iijima, Tomoki Aoyama

    BMC geriatrics   21 巻 ( 1 ) 頁: 698 - 698   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Sarcopenia and knee osteoarthritis (OA) are two major risk factors for falls in older adults. The coexistence of these two conditions may exacerbate the risk of falls. This cross-sectional study aimed to test the hypothesis that older adults with coexisting sarcopenia and knee OA displayed an increased risk of falls experience. METHODS: Participants recruited from an orthopedic clinic were divided into four groups according to the presence of sarcopenia and radiographic knee OA: isolated sarcopenia, isolated knee OA, sarcopenia + knee OA, and control (i.e., non-sarcopenia with non-OA) groups. We used questionnaires to assess falls experience in the prior 12 months. We performed logistic regression analyses to evaluate the relationship between the four groups and falls experience. RESULTS: Of 291 participants (age: 60-90 years, 78.7% women) included in this study, 25 (8.6%) had sarcopenia + knee OA. Participants with sarcopenia + knee OA had 4.17 times (95% confidence interval: 0.84, 20.6) higher odds of recurrent falls (≥2 falls) than controls after adjustment for age, sex, and body mass index. The increased recurrent falls experience was not clearly confirmed in participants with isolated sarcopenia and isolated knee OA. CONCLUSIONS: People with coexisting of sarcopenia and knee OA displayed increased recurrent falls experience. This study suggests a new concept, "sarcopenic knee OA", as a subgroup associated with higher risk of falls, which should be validated in future large cohort studies. TRIAL REGISTRATION: Not applicable.

    DOI: 10.1186/s12877-021-02654-4

    PubMed

  4. Analysis of Spastic Gait in Patients With Cervical Myelopathy Using the Timed Up and Go Test With a Laser Range Sensor. 国際誌

    Takafumi Koyama, Koji Fujita, Hirotaka Iijima, Mio Norose, Takuya Ibara, Toru Sasaki, Toshitaka Yoshii, Akimoto Nimura, Masaki Takahashi, Atsushi Okawa

    Spine     2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    STUDY DESIGN: Cross-sectional study. OBJECTIVE: This study aimed to objectively evaluate spastic gait and reveal its novel characteristics via analysis of gait in patients with cervical myelopathy (CM) using the Timed Up and Go (TUG) test with a laser range sensor. SUMMARY OF BACKGROUND DATA: Among patients with CM, spastic gait is a common diagnostic symptom; thus, objective assessments of spastic gait would be useful for the diagnosis of CM and recognition of disease status. Although spastic gait has been objectively evaluated in previous studies, the methods employed in those studies are not suitable for clinical settings. METHODS: In total, 37 and 24 participants were recruited for a control group and CM group, respectively. CM was diagnosed by spine surgeons. We developed a laser TUG test, in which the position and velocity of both the legs were captured. The parameter values for both groups were statistically compared, and odds ratios were calculated using logistic regression analyses. RESULTS: The total TUG test time, time to stand up, time to first step, number of steps, and trajectory error for the CM group were significantly higher than those for the control group, whereas the average velocity and average stride length for the CM group were significantly lower than those for the control group. There was a significant independent association between the total TUG test time and CM. The optimal cutoff point of the total test time for CM risk was approximately 9 seconds. CONCLUSION: Through the use of the laser TUG test, we were able to identify characteristics of spastic gait, which leads to difficulty in standing and taking the first step, wobbling while walking, and an increased risk of falling. We found that the risk of CM was higher if the individual took longer than 9 seconds to complete the TUG test.Level of Evidence: 4.

    DOI: 10.1097/BRS.0000000000004284

    PubMed

  5. Microcurrent Therapy as a Therapeutic Modality for Musculoskeletal Pain: A Systematic Review Accelerating the Translation From Clinical Trials to Patient Care. 国際誌

    Iijima H, Takahashi M

    Archives of rehabilitation research and clinical translation   3 巻 ( 3 ) 頁: 100145 - 100145   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.arrct.2021.100145

    PubMed

  6. Staircase design for health monitoring in elderly people

    Ogawa Ami, Iijima Hirotaka, Takahashi Masaki

    JOURNAL OF BUILDING ENGINEERING   37 巻   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Building Engineering  

    The need for early detection and intervention for age-related health deterioration via home-based health monitoring systems is growing with global population aging. Health deterioration is typically evaluated using questionnaires, but obtaining frequent responses is difficult. Although stair walking involving a high physical load is suitable for assessing health deterioration, uniform assessment using home-based systems is difficult because different stair designs result in different movements. There is currently insufficient research on differences in evaluation performance between different stair designs. The current study aimed to develop an objective index to assess difficulties in activities of daily living (ADLs) as an indicator of health deterioration by observing stair walking, and to investigate the effects of stair dimensions on the relationship between the index and health deterioration. We hypothesized that knee joint positions during stair ascent would be associated with health deterioration, and developed the “Stepping in Level” index, reflecting the knee joint position when stepping in, obtained using a markerless depth information-based system. Seventy elderly people ascended two types of stairs (steep: 33.7°; shallow: 28.2°) and completed a questionnaire regarding ADL difficulty. We used a generalized linear mixed model to investigate the ability of “Stepping in Level” to explain ADL difficulty. The results revealed that “Stepping in Level” was able to explain ADL difficulty, and steep stairs were more suitable than shallow stairs for assessment. Our system enables daily assessment of difficulty in ADLs and detection of subtle changes in daily life. The current findings could inform design guidelines for health monitoring.

    DOI: 10.1016/j.jobe.2021.102152

    Web of Science

    Scopus

  7. Low Back Pain as a Risk Factor for Recurrent Falls in People With Knee Osteoarthritis. 国際誌

    Iijima H, Shimoura K, Aoyama T, Takahashi M

    Arthritis care & research   73 巻 ( 3 ) 頁: 328 - 335   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Arthritis Care and Research  

    Objective: Knee osteoarthritis (OA) has been suggested to increase the risk of falls. Low back pain (LBP) is a potential risk factor for falls in people with knee OA, but this issue has not been addressed adequately in previous studies. The objective of this study was to investigate the relationship between LBP and falls in people with knee OA in a 12-month period. Methods: Participants with knee OA (Kellgren/Lawrence [K/L] grade ≥1) completed questionnaires for LBP and falls that occurred in the preceding 12 months. Binary and ordinal logistic regression analyses were performed to assess the relationship between LBP or moderate-to-severe LBP (numeric rating scale ≥4 points) and any fall (≥1 fall) or recurrent falls (≥2 falls) after adjustment for age, sex, K/L grade, knee pain severity, and quadriceps strength. Sensitivity analyses were performed excluding people with sciatica, nonchronic LBP, K/L grade 1, and those receiving pain medications. Results: We included 189 participants (ages 61–90 years, 78.3% women) in this study. Of these participants, 41 (21.6%) reported falls in the preceding 12 months. People with any LBP (n = 101) and those with moderate-to-severe LBP (n = 45) had 2.7- and 3.7-times higher odds of recurrent falls, respectively. Sensitivity analyses revealed a strong correlation between moderate-to-severe LBP and recurrent falls. Conclusion: Thorough investigation of LBP as a risk factor for recurrent falls in people with knee OA may provide a novel insight into the pathomechanics of recurrent falls in this population.

    DOI: 10.1002/acr.24136

    Web of Science

    Scopus

    PubMed

  8. Relationship Between Varus Thrust During Gait and Low Back Pain in Individuals With Knee Osteoarthritis. 国際誌

    Iijima H, Suzuki Y, Aoyama T, Takahashi M

    Arthritis care & research   72 巻 ( 9 ) 頁: 1231 - 1238   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Arthritis Care and Research  

    Objective: To test the hypothesis that varus thrust visualized during gait is associated with a higher prevalence of low back pain (LBP) in individuals with knee osteoarthritis (OA). Methods: Individuals with knee OA (Kellgren/Lawrence grade ≥1) underwent a gait observation to assess varus thrust. The participants identified LBP and its severity using questionnaires. Logistic regression analyses were performed to examine the association between varus thrust and LBP. Results: We included 205 participants (mean age 68.19 years; 72.20% women). A total of 45 participants (22.0%) showed varus thrust in their painful knee, in whom 31 (68.89%) and 18 (40.00%) were identified as having any LBP and moderate-to-severe LBP (numerical rating scale ≥4 points), respectively. Patients with varus thrust demonstrated a 3.6-fold higher risk of the presence of moderate-to-severe LBP (95% confidence interval [95% CI] 1.62–8.10). In patients with LBP, the presence of varus thrust was associated with more severe LBP intensity (proportional odds ratio 2.25 [95% CI 1.02–4.96]). Conclusion: This study highlights the novel relationship between varus thrust and LBP, which supports the idea of a biomechanical link, the so-called knee–spine syndrome. These findings provide new insight for clarifying the pathogenesis of LBP related to knee OA.

    DOI: 10.1002/acr.24020

    Web of Science

    Scopus

    PubMed

  9. Gait analysis of patients with distal radius fracture by using a novel laser Timed Up-and-Go system. 国際誌

    Koji Fujita, Hirotaka Iijima, Ryo Eguchi, Tomoyuki Kuroiwa, Toru Sasaki, Yukihiro Yokoyama, Takafumi Koyama, Akimoto Nimura, Ryuichi Kato, Atsushi Okawa, Masaki Takahashi

    Gait & posture   80 巻   頁: 223 - 227   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Postmenopausal women are at risk of fall and fracture with the physical decline. Distal radius fracture (DRF) is considered as the primary fragility fracture, and women with this fracture showed poor results in the usual Timed Up-and-Go (TUG) test, indicating a decline in balance and physical ability. The detailed physical characteristics of female DRF patients have not been extensively examined. RESEARCH QUESTION: Is the novel laser TUG system able to detect and analyze the detailed gait characteristics in patients with DRF whose physical ability has tended to decline? METHODS: In this cross-sectional case control study, the gait characteristics of 32 female patients with DRF who had undergone surgery were evaluated at 2 weeks postoperatively with a laser TUG system to analyze the detailed leg motion during normal TUG test. Forty-three age- and sex-matched non-fractured women were evaluated by the laser TUG system as controls. Lifestyle and present illness were corrected at the time of TUG measurement. Detailed data during laser TUG in both groups were compared statistically, and odds ratio and thread shod of the fracture was elucidated through a logistic regression analysis. RESULTS: DRF patients showed slower speed and had to do more steps to complete the TUG test. Furthermore, asymmetric trajectory and significantly further distance from the marker were observed. Thirteen steps to complete the TUG test was the thread shod of DRF. SIGNIFICANCE: Detailed gait characteristics of patients with DRF were detected by the laser TUG system. The gait decline and abnormality could be one of the reasons of consecutive fragility fracture. To prevent secondary fragility fractures, this system can be useful for screening.

    DOI: 10.1016/j.gaitpost.2020.06.005

    PubMed

  10. State of the Field of waist-mounted sensor algorithm for gait events detection: A scoping review. 国際誌

    Iijima H, Takahashi M

    Gait & posture   79 巻   頁: 152 - 161   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Gait and Posture  

    Background: A waist-mounted sensor is an attractive option for detecting initial and end of foot contacts during gait in a clinical setting without disturbing the subject's natural gait. Research question: To examine the current state of the field regarding waist-mounted sensor algorithms for gait event detection during locomotion in adults. Methods: A scoping review design was used to search peer-reviewed literature or conference proceedings published through October 2018 for algorithms for gait event detection. We analyzed data from the studies in a descriptive manner. Results: In total, 588 potentially relevant articles were selected, of which 14 (171 participants, mean age: 44.0 years) met the inclusion criteria. We identified 15 algorithms developed using biomechanical theories including the inverted pendulum model that represents gait during level walking. Most algorithms estimated gait events using triaxial acceleration data with an absolute error of approximately 50–100 ms in healthy adults. However, there was a large amount of inter-trial heterogeneity, and only a few algorithms were validated in patients with neurological diseases. Lower gait speed reduced the accuracy of gait event estimation. Significance: There was no algorithm that showed outstanding performance in the estimation of gait events during level walking using the waist-mounted sensor. More comparisons of all available algorithms with an established reference standard for one data-set are needed to identify the best algorithms. As patients with pathological conditions display altered trunk acceleration and slower gait speeds, the development of an algorithm that does not rely on particular signal characteristics and is robust for a wide range of gait speeds is needed before a specific algorithm can be recommended as a valid strategy for clinical practice.

    DOI: 10.1016/j.gaitpost.2020.03.021

    Web of Science

    Scopus

    PubMed

  11. Transcutaneous Electrical Nerve Stimulation Improves Stair Climbing Capacity in People with Knee Osteoarthritis. 国際誌

    Iijima H, Eguchi R, Shimoura K, Yamada K, Aoyama T, Takahashi M

    Scientific reports   10 巻 ( 1 ) 頁: 7294 - 7294   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Scientific Reports  

    This study aimed to examine the effect of transcutaneous electrical nerve stimulation (TENS) on stair climbing capacity in individuals with pre-radiographic to mild knee osteoarthritis (OA). This is a secondary analysis of data from a single, participant-blinded, randomized controlled trial with a pre-post design. Participants with pre-radiographic to mild knee OA (mean age, 59.1 years; 72.9% women) were randomly assigned into two groups, a TENS (n = 30) and a sham-TENS groups (n = 29). TENS or sham-TENS treatments were applied to all participants by using the prototype TENS device with pre-specified parameters. The primary outcome measures included valid and reliable functional measures for stair climbing (stair-climb test [SCT]), visual analog scale for knee pain during the SCT, and quadriceps muscle strength. TENS improved SCT time by 0.41 s (95% confidence interval [CI]: 0.07, 0.75). The time reduction in the transition phase explains the TENS therapeutic effect. Post-hoc correlation analyses revealed a non-significant but positive relationship between the pain relief effect and improved 11-step SCT time in the TENS group but not in the sham-TENS group. These results indicate that the TENS intervention may be an option for reducing the burden of early-stage knee OA.

    DOI: 10.1038/s41598-020-64176-0

    Web of Science

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  12. Pain catastrophizing affects stair climbing ability in individuals with knee osteoarthritis. 国際誌

    Yusuke Suzuki, Hirotaka Iijima, Tomoki Aoyama

    Clinical rheumatology   39 巻 ( 4 ) 頁: 1257 - 1264   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: The association between pain catastrophizing and ability to perform activities of daily living (ADL) requiring weight bearing, in particular stair climbing, standing from a seated position, and walking, in individuals with knee osteoarthritis (OA) is unclear. This study aimed to investigate the association between pain catastrophizing and ability to perform these ADLs by this population. METHOD: This cross-sectional study included individuals with knee OA (Kellgren and Lawrence grades 1-4). The ability to perform ADL was evaluated using the knee OA-related health domain measure (Japanese Knee Osteoarthritis Measure). Pain catastrophizing was evaluated using the Pain Catastrophizing Scale. The association between pain catastrophizing and ability to perform ADL, in particular stair climbing, standing from a seated position, and walking, was evaluated using the logistic regression analysis. Three types of sensitivity analysis were performed to validate the results of the logistic regression analysis. RESULTS: A total of 151 participants were included in the final analysis. When adjusted for covariates, those with pain catastrophizing showed significantly decreased stair climbing ability (odds ratio 8.84; 95% confidence interval 1.37 to 56.92). Moreover, the results did not change even with sensitivity analysis. By contrast, when adjusted for covariates, those with pain catastrophizing did not show significantly decreased ability to stand from a seated position and walk. CONCLUSION: Pain catastrophizing in knee OA patients showed significantly decreased stair climbing ability. There is a need to consider the effect of pain catastrophizing in rehabilitation of knee OA patients with decreased ability to climb stairs.Key Points• Pain catastrophizing in knee OA patients showed significantly decreased stair climbing ability.• Ability to stand from a seated position and walk were not affected by pain catastrophizing.• There is a need to consider the effect of pain catastrophizing in rehabilitation of knee OA patients with decreased ability to climb stairs.

    DOI: 10.1007/s10067-019-04881-y

    PubMed

  13. Hip abductor muscle weakness and slowed turning motion in people with knee osteoarthritis. 国際誌

    Hirotaka Iijima, Ayanori Yorozu, Yusuke Suzuki, Ryo Eguchi, Tomoki Aoyama, Masaki Takahashi

    Journal of biomechanics   101 巻   頁: 109652 - 109652   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Laser range sensor-based timed up and go (laser-TUG) test can evaluate performance in TUG subtasks (sit-to-walk [STW], walking a short distance, and turning). This study aimed to test the hypothesis that weaker hip abductor muscle strength is more significantly associated with slowed turning speed than with the other TUG subtasks (STW and straight walking) after controlling for quadriceps muscle strength in patients with knee osteoarthritis (OA). Community-dwelling participants with knee OA (Kellgren and Lawrence [K&L] grade ≥ 1; mean age, 68.6 years; 70.3% women) underwent laser-TUG. Spatiotemporal gait parameters in TUG and the TUG subtasks were evaluated as outcome measures. The isometric muscle strength of the hip abductor and quadriceps was measured using a hand-held dynamometer. Multiple linear regression analysis was performed to examine the relationship between muscle strength as an independent variable and spatiotemporal parameters as dependent variables. The relative importance of hip abductor muscle strength was determined using the percentages of unique variance. Participants with weaker hip abductor muscle strength demonstrated 0.094 m/s slower turning speed after adjustment for covariates including quadriceps muscle strength. The unique variance explained by hip abductor muscle strength in turning speed was 2.1%. However, no significant relationships were confirmed between weak hip abductor muscle strength and the time to perform TUG and the straight walking (forward and return) phase. These findings indicate that turning motion may be more sensitive to aggravated hip abductor muscle weakness and may show better response to hip muscle strengthening exercises. Longitudinal studies are warranted to elucidate this issue.

    DOI: 10.1016/j.jbiomech.2020.109652

    PubMed

  14. Contralateral limb effect on gait asymmetry and ipsilateral pain in a patient with knee osteoarthritis: A proof-of-concept case report 査読有り

    Hirotaka Iijima, Mami Inoue, Yusuke Suzuki, Kanako Shimoura, Tomoki Aoyama, Katsuyuki Madoba, Masaki Takahashi

    JBJS Case Connect   10 巻 ( 1 )   2020年

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    担当区分:筆頭著者  

  15. Detailed analysis of the transverse arch of hallux valgus feet with and without pain using weightbearing ultrasound imaging and precise force sensors. 国際誌

    Hala Zeidan, Eguchi Ryo, Yusuke Suzuki, Hirotaka Iijima, Yuu Kajiwara, Keiko Harada, Kengo Nakai, Kanako Shimoura, Koji Fujimoto, Masaki Takahashi, Tomoki Aoyama

    PloS one   15 巻 ( 1 ) 頁: e0226914   2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Hallux valgus is the most common forefoot deformity and affects the transverse arch structure and its force loading patterns. This study aims to clarify the differences in the transverse arch structure and the force under the metatarsal heads individually, between normal feet and hallux valgus feet, and between hallux valgus feet with pain and without pain. We further test the association between the parameters of the transverse arch and hallux valgus angle and between the parameters and pain in hallux valgus. METHODS: Women's feet (105 feet) were divided into normal group (NORM) and hallux valgus group (HVG); and further into subgroups: hallux valgus without pain (HV Pain (-)) and hallux valgus with pain (HV Pain (+)). Transverse arch height and metatarsal heads height were measured using weight-bearing ultrasound imaging. Force under the metatarsal heads was measured using force sensors attached directly on the skin surface of the metatarsal heads. The measurements were taken in three loading positions: sitting, quiet standing and 90% weight shift on the tested foot. Differences between the groups were compared using Student t-test and Wilcoxon Exact test. Multivariate logistic analysis with adjustment for physical characteristics was also conducted. RESULTS: Transverse arch height was significantly higher in HVG than in NORM in all positions; there were no significant differences between HV Pain (+) and HV pain (-). Lateral sesamoid was significantly higher in HVG and HV Pain (+) than in NORM and HV Pain (-) respectively when bearing 90% of the body weight unilaterally. There was a trend of higher forces under the medial forefoot without significant difference. Transverse arch height and lateral sesamoid height were associated with the hallux valgus angle, while lateral sesamoid height was associated with forefoot pain in hallux valgus deformity. CONCLUSIONS: This study shows the differences in the transverse arch structure between normal feet and feet with hallux valgus, and between hallux valgus feet with and without pain. This finding is noteworthy when considering future treatments of painful feet, notably the height of the lateral sesamoid which seems to play a role in forefoot pain.

    DOI: 10.1371/journal.pone.0226914

    PubMed

  16. Altered sagittal plane kinematics and kinetics during sit-to-stand in individuals with knee osteoarthritis: A systematic review and meta-analysis. 国際誌

    Moeka Sonoo, Hirotaka Iijima, Naohiko Kanemura

    Journal of biomechanics   96 巻   頁: 109331 - 109331   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Knee osteoarthritis (OA) progression is associated with an increase in peak external knee flexion torque (EKFT) during gait. However, the difference in the peak EKFT between individuals with knee OA and age-matched subjects was unclear. Therefore, to understand the kinematics, kinetics, and electromyogram characteristics in individuals with knee OA, we conducted a systematic review and meta-analysis of sagittal plane-dominant sit-to-stand (STS) motion. PubMed, PEDro, CINAHL, and Cochrane CENTRAL were used. Fourteen articles (knee-OA group: n = 323, mean age = 65.0 years, mean weight = 79.2 kg; control group: n = 224, mean age = 64.4 years, mean weight = 70.4 kg) were included, and the pooled standardized mean differences (SMDs) were calculated using a random-effects model. Meta-analysis showed that individuals with knee OA present significantly lower peak EKFT (pooled SMD: -1.62; 95% confidence interval [CI]: -2.36 to -0.88), significantly large trunk flexion angle (pooled SMD: 1.04; 95% CI: 0.69 to 1.39), and no significantly lower peak external knee adduction torque despite the significantly larger lateral-lean angle to the less affected side (pooled SMD: 1.04; 95% CI: 0.69 to 1.39). The quality of evidence for all outcomes was very low. The descriptive synthesis indicates that STS motion in individuals with knee OA might be an unsuitable motion strategy for knee muscle activity, force utilization from multiple joints to the knee joint, and their influence on knee joint cartilage, despite their lower peak EKFT. This information can help to better understand movement strategies and to optimize treatment approaches for individuals with knee OA.

    DOI: 10.1016/j.jbiomech.2019.109331

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  17. Lower-body positive pressure diminishes surface blood flow reactivity during treadmill walking. 国際誌

    Tajino J, Ito A, Torii Y, Tsuchimoto K, Iijima H, Zhang X, Tanima M, Yamaguchi S, Ieki H, Kakinoki R, Kuroki H

    BMC research notes   12 巻 ( 1 ) 頁: 733 - 733   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC Research Notes  

    Objective: The purpose of this study was to determine the effects of the lower-body positive pressure on surface blood flow during standing still and treadmill walking to explore cardiovascular safety for application to rehabilitation treatment. Thirteen healthy volunteers participated in the experiment and surface blood flows were measured in the forehead, thigh, calf, and the top of the foot during standing still and walking under various pressure conditions (0 kPa, 5 kPa, and 6.7 kPa). Results: Lower-body positive pressure decreased the blood flow in the forehead and the thigh during walking (p <.05 for each), whereas an increasing trend in blood flow was observed during standing still (p <.05). Furthermore, in the forehead and thigh, the extent of blood flow increase at the onset of walking was found to decrease in accordance with the applied pressure (p <.01 for each). These findings suggest that during walking, lower-body positive pressure modulates the blood flow, which implies safeness of this novel apparatus for use during orthopedic rehabilitation treatment.

    DOI: 10.1186/s13104-019-4766-2

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  18. Patients with early-stage knee osteoarthritis and knee pain have decreased hip abductor muscle strength while descending stairs. 国際誌

    Suzuki Y, Iijima H, Shimoura K, Tsuboyama T, Aoyama T

    Clinical rheumatology   38 巻 ( 8 ) 頁: 2249 - 2254   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical Rheumatology  

    Introduction/objectives: This study aimed to investigate the association between hip abductor muscle strength and knee pain in patients with early-stage knee osteoarthritis (OA) while ascending and descending stairs. Method: This cross-sectional study included individuals with early-stage knee OA (Kellgren/Lawrence grades 1 or 2). Knee pain while ascending and descending stairs was evaluated using a knee OA-related health domain measure (Japanese Knee Osteoarthritis Measure). Knee extension and hip abductor muscle strength were also evaluated. The association between hip abductor muscle strength and knee pain while ascending and descending stairs was evaluated using multiple regression analysis. Results: A total of 157 participants were included in the final analysis. After the adjustment for age, sex, and knee extension strength, those with knee pain while descending stairs showed significantly decreased hip abductor muscle strength (β, − 0.09; 95% confidence interval [CI], − 0.19 to − 0.003). In contrast, after the adjustment for age, sex, and knee extension muscle strength, those with knee pain while ascending stairs did not have significantly decreased hip abductor muscle strength (β, − 0.06; 95% CI, − 0.15 to 0.02). Conclusions: Patients with early-stage knee OA and knee pain while descending stairs had significantly reduced hip abductor muscle strength.

    DOI: 10.1007/s10067-019-04523-3

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  19. Stair climbing ability in patients with early knee osteoarthritis: Defining the clinical hallmarks of early disease. 国際誌

    Iijima H, Eguchi R, Shimoura K, Aoyama T, Takahashi M

    Gait & posture   72 巻   頁: 148 - 153   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Gait and Posture  

    Background: A growing clinical interest has been shown towards identifying knee osteoarthritis (OA) patients at earlier stages. The early detection of knee OA may allow for more effective interventions. Research question: The aim of this study was to determine the discriminative ability of a stair-climb test (SCT) in identifying patients with early knee OA, and to determine if descending stair time during the SCT is better than ascending stair time for the identification of these patients. Methods: This study was a secondary, cross-sectional analysis of baseline data from a randomized controlled trial. Adults with moderate to severe knee pain were enrolled (n = 57; mean age 58.9 years; 71.9% women). Each participant performed an 11-step SCT (11-SCT) while wearing shoes with a pressure sensor insole. A receiver operating characteristic analysis was used to examine the discriminative power of 11-SCT for identifying early knee OA (Kellgren and Lawrence grade 1). The discriminative power was also compared between the ascending and descending 11-SCT time as evaluated by the pressure sensor. Results: The 11-SCT time in patients with early knee OA was 0.55 s longer than that in those with symptomatic non-radiographic OA. A one-second increase in the 11-SCT time was significantly associated with 1.9-fold increased odds of early knee OA being present. The 11-SCT value with the best balance of sensitivity and specificity for identifying early knee OA was 8.33 s (area under the curve: 0.711). The descending time was not significantly better than the ascending time for identifying early knee OA. Significance: This study determined the time values of an 11-SCT that may be useful for identifying early knee OA patients. These preliminary findings may serve as the foundation for future studies investigating the clinical hallmarks associated with early knee OA.

    DOI: 10.1016/j.gaitpost.2019.06.004

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  20. Effects of interaction between varus thrust and ambulatory physical activity on knee pain in individuals with knee osteoarthritis: an exploratory study with 12-month follow-up. 国際誌

    Hirotaka Iijima, Tomoki Aoyama, Ryo Eguchi, Masaki Takahashi, Shuichi Matsuda

    Clinical rheumatology   38 巻 ( 6 ) 頁: 1721 - 1729   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: This study aimed to examine the interaction effect between ambulatory physical activity (PA) and varus thrust on knee pain in individuals with knee osteoarthritis (OA). METHOD: Subjects (n = 207; mean age: 73.1 years, 71.5% women) in orthopedic clinics with diagnosed knee OA (Kellgren/Lawrence grade ≥ 1) were enrolled in this 12-month observational cohort study. Participants underwent gait observation for varus thrust assessment and pedometer-based ambulatory PA measurements at baseline and 12-month follow-up. Knee pain intensity was assessed using the Japanese Knee Osteoarthritis Measure pain subscale as a primary outcome measure. Multiple linear regression analyses were performed to evaluate ambulatory PA-thrust interaction on knee pain intensity. RESULTS: Ninety-two subjects (mean age, 73.4 years; 68.5% women) completed the 12-month follow-up assessment. Baseline ambulatory PA-thrust interaction was significant (P = 0.017) in the cross-sectional analysis, adjusting for covariates, which yielded R2 = 0.310. Subgroup analysis showed that varus thrust was significantly associated with worse knee pain in subjects walking ≥ 5000 steps/day adjusting for covariates (beta: 7.94; 95% CI: 3.82, 12.1; P < 0.001) with a higher predictive ability (R2 = 0.664). In contrast, ambulatory PA-thrust interaction in the longitudinal analysis showed no significant association with knee pain changes. CONCLUSIONS: Ambulatory PA interacted with varus thrust in the association with knee pain, as coexisting high ambulatory PA and varus thrust had the strongest association with higher knee pain. Maximal pain relief effects might be achieved when both ambulatory PA and varus thrust are treated simultaneously, rather than treating each separately.

    DOI: 10.1007/s10067-019-04472-x

    PubMed

  21. Proximal gait adaptations in individuals with knee osteoarthritis: A systematic review and meta-analysis. 国際誌

    Iijima H, Shimoura K, Ono T, Aoyama T, Takahashi M

    Journal of biomechanics   87 巻   頁: 127 - 141   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Biomechanics  

    Clarifying proximal gait adaptations as a strategy to reduce knee joint loading and pain for individuals with knee osteoarthritis (OA) contributes to understanding the pathogenesis of multi-articular OA changes and musculoskeletal pain in other joints. We aimed to determine whether biomechanical alterations in knee OA patients during level walking is increased upper trunk lean in the frontal and sagittal planes, and subsequent alteration in external hip adduction moment (EHAM) and external hip flexion moment (EHFM). A literature search was conducted in PubMed, PEDro, CINAHL, and Cochrane CENTRAL through May 2018. Where possible, data were combined into a meta-analysis; pooled standardized mean differences (SMD) of between knee OA patients and healthy adults were calculated using a random-effect model. In total, 32 articles (2037 participants, mean age, 63.0 years) met inclusion criteria. Individuals with knee OA had significantly increased lateral trunk lean toward the ipsilateral limb (pooled SMD: 1.18; 95% CI: 0.59, 1.77) along with significantly decreased EHAM. These subjects also displayed a non-significantly increased trunk/pelvic flexion angle and EHFM. The GRADE approach judged all measures as “very low.” These results may indicate that biomechanical alterations accompanying knee OA are associated with increased lateral trunk lean and ensuing alterations in EHAM. Biomechanical alterations in the sagittal plane were not evident. Biomechanical adaptations might have negative sequelae, such as secondary hip abductor muscle weakness and low back pain. Thus, investigations of negative sequelae due to proximal gait adaptations are warranted.

    DOI: 10.1016/j.jbiomech.2019.02.027

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  22. Quadriceps Weakness in Individuals with Coexisting Medial and Lateral Osteoarthritis. 国際誌

    Iijima H, Suzuki Y, Aoyama T, Takahashi M

    JB & JS open access   4 巻 ( 1 ) 頁: e0028   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JBJS Open Access  

    Background: This study examined whether individuals who have mild medial osteoarthritis (OA) of the knee with coexisting lateral OA have less muscle strength than individuals who do not have lateral OA. Methods: A series of 153 individuals (84% of whom were women) between 48 and 88 years old who had Kellgren and Lawrence (KL) grade-2 OA in the medial compartment of the knee underwent radiographic evaluation to assess the presence of lateral OA, which was graded with the system of the Osteoarthritis Research Society International (OARSI) atlas as well as the KL system. The isometric maximum strengths of the quadriceps, the hip abductors, and the hip extensors were evaluated with use of a handheld dynamometer. Results: Individuals who had coexisting medial and lateral OA had more severe knee pain and weaker quadriceps than those who did not have lateral OA. The study adjusted for age and sex both for the OARSI atlas system (adjusted difference in mean strength: 0.272 Nm/kg, 95% confidence interval [CI]: 0.143 to 0.401 Nm/kg) and for KL grading (adjusted difference in mean strength: 0.185 Nm/kg, 95% CI: 0.061 to 0.309 Nm/kg). Logistic regression analysis showed that weakness of the quadriceps increased the odds of the presence of lateral OA sevenfold after adjustments using the OARSI atlas were made for age, sex, anatomical axis, range of motion of the knee, and intensity of pain in the knee. Conclusions: Individuals who had coexisting medial and lateral OA had weaker quadriceps than individuals who had mild medial OA alone. Paying close attention to quadriceps weakness might provide a key to clarifying the pathogenesis of bicompartmental disease in the tibiofemoral joint.

    DOI: 10.2106/JBJS.OA.18.00028

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  23. Trunk movement asymmetry associated with pain, disability, and quadriceps strength asymmetry in individuals with knee osteoarthritis: a cross-sectional study. 国際誌

    Iijima H, Eguchi R, Aoyama T, Takahashi M

    Osteoarthritis and cartilage   27 巻 ( 2 ) 頁: 248 - 256   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Osteoarthritis and Cartilage  

    Objective: This study examined 1) the clinical relevance of trunk movement asymmetry, which was evaluated using a trunk-mounted inertial measurement unit (IMU), and 2) the relationship between trunk movement asymmetry and lower limb muscle strength asymmetry in individuals with knee osteoarthritis (OA). Design: One-hundred-thirty-one participants (mean age, 74.2 years; 71.8% female; Kellgren and Lawrence [K&L] grade ≥1) underwent gait analysis at their preferred pace for IMU-based measurement of trunk movement asymmetry (harmonic ratio [HR] and improved HR). The isometric strength of quadriceps and hip abductors was evaluated using a hand-held dynamometer. Pain and disability level were evaluated using a validated self-reported questionnaire. Multiple regression analyses with covariate adjustment were performed to examine the relationship between trunk movement asymmetry (independent variable) and pain, disability level, or muscle strength asymmetry (dependent variables). Results: Individuals with severe knee OA (K&L grade ≥3) had increased trunk movement asymmetry in the medio-lateral axis compared to those with a K&L grade of 1. Increased trunk movement asymmetry was associated with a greater knee pain and disability. The increased trunk movement asymmetry was significantly associated with an increase in the asymmetry of quadriceps strength, but not with asymmetry in the strength of hip abductor. Conclusion: Our findings indicate that increased medio-lateral trunk movement asymmetry may be an indicator of impairment, rather than adaptation, in individuals with knee OA. This preliminary finding warrants validation by future study. Paying close attention to medio-lateral trunk movement asymmetry may be key to our understanding of OA-related pain and disability.

    DOI: 10.1016/j.joca.2018.10.012

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  24. Concurrent validity and measurement error of stair climb test in people with pre-radiographic to mild knee osteoarthritis. 国際誌

    Hirotaka Iijima, Kanako Shimoura, Ryo Eguchi, Tomoki Aoyama, Masaki Takahashi

    Gait & posture   68 巻   頁: 335 - 339   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Stair climbing is the task first affected in patients with knee osteoarthritis (OA); therefore, the precise measurement of time required to climb stairs is important to identify mobility limitations, particularly in the early phase of knee OA. RESEARCH QUESTION: This study aimed to examine the test-retest reliability, measurement error, and concurrent validity of the stopwatch-based stair-climb test (SCT) in adults with pre-radiographic to mild knee OA. METHODS: Fifty-nine participants (mean age, 59.1 [range, 50-69] years; 72.9% female) with Kellgren and Lawrence grade ≤2 disease underwent an 11-step SCT (11-SCT) in accordance with the Osteoarthritis Research Society International recommended method while wearing pressure sensor-mounted standard shoes that is used as a gold standard procedure. Test-retest reliability, measurement errors, and the concurrent validity of the stopwatch-based 11-SCT were evaluated. RESULTS: The test-retest reliability of the stopwatch-based 11-SCT was excellent (intra-class correlation coefficient1,1 [ICC1,1], 0.952; 95% confidence interval [CI], 0.560 to 0.985; p <  0.001) and the minimal detectable change95 was 0.102 s. Concurrent validity was excellent (ICC2,1: 0.957; 95% CI: 0.661 to 0.986; p <  0.001). SIGNIFICANCE: The stopwatch-based 11-SCT had high test-retest reliability and high concurrent validity, which justify its clinical use for identifying mobility limitations in individuals with pre-radiographic to mild knee OA. A difference of 0.2 s in the stopwatch-based 11-SCT time would be considered a true difference beyond a 95% measurement error.

    DOI: 10.1016/j.gaitpost.2018.12.014

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  25. Immediate Effects of Transcutaneous Electrical Nerve Stimulation on Pain and Physical Performance in Individuals With Preradiographic Knee Osteoarthritis: A Randomized Controlled Trial. 国際誌

    Kanako Shimoura, Hirotaka Iijima, Yusuke Suzuki, Tomoki Aoyama

    Archives of physical medicine and rehabilitation   100 巻 ( 2 ) 頁: 300 - 306   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To investigate the effect of transcutaneous electrical nerve stimulation (TENS) on knee pain and comprehensive physical function in preradiographic knee osteoarthritis. DESIGN: A single, participant-blinded, randomized controlled trial (RCT) with pre-post design. SETTING: University research laboratory. PARTICIPANTS: Patients with knee pain belonging to Kellgren-Lawrence grade 0 or 1 (N=50; aged 50-69y) were randomly assigned to the TENS (n=25) and sham-TENS groups (n=25). INTERVENTIONS: All participants wore the TENS device under the patella of the symptomatic knee. After measurement, the TENS devices in the TENS group were turned on, and those in the sham-TENS group were not connected. MAIN OUTCOME MEASURES: The primary outcome measures included the stair climb test, timed Up and Go (TUG) test, 6-minute walk test (6MWT), and knee pain evaluated using the visual analog scale (VAS) for stair climb test, TUG test, and 6MWT. Secondary outcomes included knee extensor strengths and the 2-step test and stand-up test from the locomotive syndrome risk test. RESULTS: Multiple regression analysis revealed that TENS intervention significantly improved the walk distance and VAS score of the 6MWT, after adjusting for premeasurement data (distance; P=.015, VAS; P=.030). CONCLUSIONS: Use of TENS improved the VAS score for pain and the distance walked in the 6MWT for individuals with Kellgren-Lawrence grade 0 or 1 of the knee. Thus, TENS may be effective for long-distance walking in patients with preradiographic knee osteoarthritis.

    DOI: 10.1016/j.apmr.2018.08.189

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  26. The Association of Variations in Hip and Pelvic Geometry With Pregnancy-Related Sacroiliac Joint Pain Based on a Longitudinal Analysis 国際誌

    Ji Xiang, Morino Saori, Iijima Hirotaka, Ishihara Mika, Kawagoe Mirei, Umezaki Fumiko, Hatanaka Yoko, Yamashita Mamoru, Tsuboyama Tadao, Aoyama Tomoki

    SPINE   44 巻 ( 2 ) 頁: E67-E73 - E73   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Spine  

    Study Design.Cross-sectional study using radiological measurements and longitudinal data analysis.Objective.We aim to explore hip/pelvic geometry on anteroposterior radiographs and examine if such parameters are associated with clinical symptoms.Summary of Background Data.Pregnancy-related sacroiliac joint pain is a common disease and is responsible to the disability of daily activities. The etiology is likely to be correlated with the biomechanical factors which are determined by trunk load and hip/pelvic geometry. Previous studies have already found the association between symptoms and weight increase during pregnancy. However, the relationship between bony anatomy and pregnancy-related sacroiliac joint pain remains unknown.Methods.In total, 72 women were included in the final analysis. In pregnant women with self-reported sacroiliac joint pain, pain scores at 12, 24, 30, and 36 weeks of pregnancy were recorded and included in a mixed-effect linear regression model as dependent variables. The radiological measurements were included as independent variables. Furthermore, to investigate the relationship between hip/pelvic geometry and the activity-specific nociceptive phenomenon, the radiological measurements between patients with and without activity-induced pain were compared using a binominal logistic regression model.Results.The relative bilateral is chial tuberosity distance (betta coefficient: 0.078; P=0.015) and the relative bilateral femoral head length (betta coefficient: 0.011; P=0.028) showed significant interactions with the slope of pain scores. Moreover, women whose pain exacerbate during prolonged walking had a higher odds in hip/pelvic geometry of the bilateral ischial tuberosity distance (odds ratio [OR]: 1.12; P=0.050) and the bilateral femoral head length (OR: 1.16; P=0.076) with approximately significant P-value.Conclusion.These data indicate hip/pelvic anatomical variations are associated with the degree of pain increasing and the activity-specific pain during pregnancy, which may help to have further understanding on the biomechanical factor in developing pregnancy-related sacroiliac joint pain.Level of Evidence: 3.

    DOI: 10.1097/BRS.0000000000002774

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  27. Periodic mild heat stimuli diminish extracellular matrix synthesis in pellet cultured human chondrocytes. 国際誌

    Akira Ito, Tomoki Aoyama, Hirotaka Iijima, Kohei Nishitani, Junichi Tajino, Hiroshi Kuroki

    BMC research notes   12 巻 ( 1 ) 頁: 16 - 16   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: This study aimed to clarify the effects of periodic mild heat stimuli on extracellular matrix (ECM) synthesis of adult human chondrocytes in 3-dimensional pellet culture. RESULTS: Human articular chondrocytes were subjected to pellet culture at 37 °C for 3 days. Thereafter, the pellets were divided into three groups: 32 °C group which was cultured at 32 °C without heat stimuli, 32 °C + Heat group which was cultured at 32 °C and applied periodic heat stimuli, 37 °C group which was cultured at 37 °C. Heat stimuli were given by transferring the pellets into a CO2 incubator set at 41 °C for 20 min/day, 6 times/week. ECM synthesis ability was evaluated by analyzing the mRNA expressions. Additionally, the collagen and proteoglycan content in the pellet was quantified. DNA content was also measured for estimating the cell amount. We found that there were no significant differences in the mRNA expression of COL2A1, COL1A1, and ACAN between the 32 °C group and 32 °C + Heat group. However, the collagen content per cell and DNA content were significantly lower in the 32 °C + Heat group compared to other groups. Our results indicate that periodic mild heat stimuli may diminish ECM synthesis due to inhibition of collagen production and loss of cells.

    DOI: 10.1186/s13104-019-4058-x

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  28. Home exercise therapy to improve muscle strength and joint flexibility effectively treats pre-radiographic knee OA in community-dwelling elderly: a randomized controlled trial. 国際誌

    Yusuke Suzuki, Hirotaka Iijima, Yuto Tashiro, Yuu Kajiwara, Hala Zeidan, Kanako Shimoura, Yuichi Nishida, Tsubasa Bito, Kengo Nakai, Masataka Tatsumi, Soyoka Yoshimi, Tadao Tsuboyama, Tomoki Aoyama

    Clinical rheumatology   38 巻 ( 1 ) 頁: 133 - 141   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    To compare the efficacy and adherence rates of two parallel home exercise therapy programs-multiple exercise (training and stretching the knee and hip muscles) and control (training the quadriceps muscles)-on knee pain, physical function, and knee extension strength in community-dwelling elderly individuals with pre-radiographic knee osteoarthritis (OA). One hundred patients with medial knee pain were randomly allocated to one of two 4-week home exercise programs. Individuals with a Kellgren/Lawrence (K/L) grade 0 or 1 OA (pre-radiographic knee OA) in the medial compartment were enrolled. Primary outcomes were knee pain (visual analog scale), self-reported physical function (Japanese Knee Osteoarthritis Measure [JKOM]), and isometric maximum muscle strength of the knee extensor measured using a hand-held dynamometer. A total of 52 patients (28 [53.8%] in the multiple exercise group, 24 [46.2%] in the control group) completed the trial. The JKOM activities of daily living and general health conditions outcomes improved significantly in the multiple exercise group compared to the control group (JKOM activities of daily living, beta = - 0.76; 95% confidence interval [CI], - 1.39 to - 0.13; p = 0.01; JKOM general health conditions, beta = - 0.25; 95% CI, - 0.48 to - 0.01; p = 0.03). The home exercise compliance rates of the multiple exercise and control groups were 96.6 and 100%, respectively. When targeting pre-radiographic knee OA in community-dwelling elderly, it is important to implement home exercise programs that aim to improve muscle strength and joint flexibility rather than knee extension muscle power only.

    DOI: 10.1007/s10067-018-4263-3

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  29. Development of a questionnaire survey to evaluate lower limb function of patients with knee osteoarthritis. 国際誌

    Yusuke Suzuki, Hirotaka Iijima, Yuto Tashiro, Yuu Kajiwara, Hala Zeidan, Kanako Shimoura, Yuichi Nishida, Tsubasa Bito, Kengo Nakai, Masataka Tatsumi, Soyoka Yoshimi, Tadao Tsuboyama, Tomoki Aoyama

    Clinical rheumatology   37 巻 ( 11 ) 頁: 3115 - 3123   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This study aimed to develop a self-questionnaire index relevant to lower limb functional assessment reflecting clinical symptoms and activity restrictions associated with activities of daily living (ADL) for patients with knee osteoarthritis. This cross-sectional study enrolled patients with knee osteoarthritis (Kellgren/Lawrence grade ≥ 1). Participants evaluated clinical symptoms and activity restrictions using self-reported questionnaires. Radiographic evaluation, knee joint range of motion (ROM), and lower limb muscle strength were assessed. Associations between clinical symptoms, activity restrictions, and knee and hip joint function were evaluated using multiple and logistic regression analysis. Overall, 142 participants were included in the final analysis. Patients with knee pain while rising from a chair had lower knee and hip extension strength (knee extension β = - 0.28; 95% confidence interval (CI), - 0.41 to - 0.14; P < 0.0001; hip extension β = - 0.26; 95% CI, - 0.42 to - 0.08; P = 0.0034), and restricted knee extension ROM (odds ratio [OR] = 2.17; 95% CI, 1.02-4.63; P = 0.041). Patients with knee pain during stair climbing, turning or who were unable to stand on one leg without external support had reduced hip abduction muscle strength (β = - 0.17; 95% CI, - 0.27 to - 0.07; P = 0.0008). Patients with knee pain while rising from a chair or stepping showed more severe knee joint degeneration on radiographic evaluation (OR = 3.26; 95% CI, 1.11-10.91; P = 0.03). The self-questionnaire index reflected clinical symptoms and activity restrictions associated with ADL and was significantly associated with lower limb function in individuals with knee osteoarthritis.

    DOI: 10.1007/s10067-018-4229-5

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  30. ULTRASOUND PARAMETERS FOR HUMAN OSTEOARTHRITIC SUBCHONDRAL BONE EX VIVO: COMPARISON WITH MICRO-COMPUTED TOMOGRAPHY PARAMETERS 国際誌

    Kiyan Wataru, Nakagawa Yasuaki, Ito Akira, Iijima Hirotaka, Nishitani Kohei, Tanima-Nagai Momoko, Mukai Shogo, Tajino Junichi, Yamaguchi Shoki, Nakahata Akihiro, Zhang Jue, Aoyama Tomoki, Kuroki Hiroshi

    ULTRASOUND IN MEDICINE AND BIOLOGY   44 巻 ( 10 ) 頁: 2115 - 2130   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ultrasound in Medicine and Biology  

    The aim of this study was to identify ultrasound parameters reflecting subchondral porosity (Po), subchondral plate thickness (Tpl) and bone volume fraction at the trabecular bone region (BV/TVTb). Sixteen osteoarthritic human lateral femoral condyles were evaluated ex vivo using a 15-MHz pulsed-echo ultrasound 3-D scanning system. The cartilage–subchondral bone (C-B) surface region (layer 1) and inner subchondral bone region (layer 2) were analyzed; we newly introduced entropy (ENT) and correlation (COR) of ultrasound texture parameters of the parallel (x) or perpendicular (z) direction to the C-B interface for this analysis. Po, Tpl and BV/TVTb were evaluated as reference measurements using micro-computed tomography. ENTL1x (ENT of layer 1, x-direction) and ENTL1z were significantly correlated with Po (both r values = 0.58), CORL2x with Tpl (r = –0.73) and CORL2z with BV/TVTb (r = –0.66). These are efficient indicators of the characteristics of osteoarthritis-related subchondral bone; the other texture parameters were not significant.

    DOI: 10.1016/j.ultrasmedbio.2018.06.003

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  31. Interaction between low back pain and knee pain contributes to disability level in individuals with knee osteoarthritis: a cross-sectional study. 国際誌

    H Iijima, Y Suzuki, T Aoyama, M Takahashi

    Osteoarthritis and cartilage   26 巻 ( 10 ) 頁: 1319 - 1325   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To test the hypothesis that the interaction between low back pain (LBP) and knee pain intensity contributes to the disability level of individuals with knee osteoarthritis (OA). DESIGN: Community-dwelling participants with knee OA (Kellgren/Lawrence [K/L] grade ≥1) were enrolled. LBP and its severity were identified using questionnaires. Knee pain severity and disability level were evaluated using the Japanese Knee Osteoarthritis Measure (JKOM) subscale. Multiple linear regression analyses were performed to examine the effect of the LBP-knee pain interaction, an independent variable, on disability, a dependent variable. RESULTS: A total of 260 participants (age, 48-88 years; 77.7% women) were included. Of them, 151 (58.1%) had LBP. The LBP-knee pain interaction was significantly associated with disability after the adjustment for covariates. A post-hoc subgroup analysis revealed that the relationship between knee pain intensity and disability level was higher in individuals with LBP (beta: 0.621 points; 95% confidence interval [CI]: 0.511 to 0.731 points) than in those without LBP (beta: 0.402 points; 95% CI: 0.316 to 0.487 points). CONCLUSIONS: LBP interacts with knee pain intensity and contributes to disability level in individuals with knee OA. Coexisting LBP and knee pain had a stronger impact on disability level than LBP or knee pain alone. These findings highlight the potential deteriorative effects of the LBP-knee interaction on disability. Maximal treatment effects for disability might be achieved when LBP and knee pain are targeted simultaneously, rather than separately.

    DOI: 10.1016/j.joca.2018.06.012

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  32. 中周波電気刺激が神経筋骨格系疾患患者の筋パフォーマンスに与える影響と有害事象の調査

    飯島 弘貴, 高橋 正樹, 田代 雄斗, 青山 朋樹

    リハビリテーション医学   55 巻 ( 9 ) 頁: 784 - 790   2018年9月

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    記述言語:日本語   出版者・発行元:公益社団法人 日本リハビリテーション医学会  

    <p>目的:神経筋骨格系疾患患者において,中周波電気刺激が筋パフォーマンスに与える効果および有害事象に関するシステマティックレビューを行った.</p><p>方法:データベースから計1,295編の論文を抽出し,そのうち適格基準に合致した3編(32名,平均年齢45.3歳)を調査対象とした.データの統合は質的に行われた.</p><p>結果:中周波電気刺激とエクササイズの組み合わせは,エクササイズ単独と比較して,人工膝関節置換術後の大腿四頭筋筋力増強に効果的である傾向を示した.推定結果の信頼性はGRADEアプローチでvery lowと判定された.脊髄損傷患者のペダリング総仕事量は,中周波電気刺激では低周波電気刺激と比較して有意差はなかった.また,重度有害事象の発生はなかった.</p><p>結論:中周波電気刺激は有害事象を示すことなく大腿四頭筋筋力増強に有効な可能性がある.今後,質の高い研究を重ね,推定結果の信頼性を高める必要がある.</p>

    DOI: 10.2490/jjrmc.17023

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  33. Three-dimensional motion analysis for comprehensive understanding of gait characteristics after sciatic nerve lesion in rodents. 国際誌

    Tajino J, Ito A, Tanima M, Yamaguchi S, Iijima H, Nakahata A, Kiyan W, Aoyama T, Kuroki H

    Scientific reports   8 巻 ( 1 ) 頁: 13585 - 13585   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Scientific Reports  

    Rodent models of sciatic nerve lesion are regularly used to assess functional deficits in nerves. Impaired locomotor functions induced by sciatic nerve lesion are currently evaluated with scoring systems despite their limitations. To overcome these shortcomings, which includes low sensitivity, little significance, and the representation of only marginal components of motion profiles, some additional metrics have been introduced. However, a quantitative determination of motion deficits is yet to be established. We used a three-dimensional motion analysis to investigate gait deficits after sciatic nerve lesion in rats. This enabled us to depict the distorted gait motion using both traditional parameters and novel readouts that are specific for the three-dimensional analysis. Our results suggest that three-dimensional motion analysis facilitates a comprehensive understanding of the gait impairment specifically, but not limited to, a sciatic lesion rat model. A broad application of these methods will improve understanding and standardized motor assessment.

    DOI: 10.1038/s41598-018-31579-z

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  34. Psychological health is associated with knee pain and physical function in patients with knee osteoarthritis: An exploratory cross-sectional study 国際誌

    Iijima H., Aoyama T., Fukutani N., Isho T., Yamamoto Y., Hiraoka M., Miyanobu K., Jinnouchi M., Kaneda E., Kuroki H., Matsuda S.

    BMC Psychology   6 巻 ( 1 ) 頁: 19 - 19   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC Psychology  

    Background: Depressive symptoms are a major comorbidity in older adults with knee osteoarthritis (OA). However, the type of activity-induced knee pain associated with depression has not been examined. Furthermore, there is conflicting evidence regarding the association between depression and performance-based physical function. This study aimed to examine (i) the association between depressive symptoms and knee pain intensity, particularly task-specific knee pain during daily living, and (ii) the association between depressive symptoms and performance-based physical function, while considering other potential risk factors, including bilateral knee pain and ambulatory physical activity. Methods: Patients in orthopaedic clinics (n=95; age, 61-91 years; 67.4% female) who were diagnosed with radiographic knee OA (Kellgren/Lawrence [K/L] grade≥1) underwent evaluation of psychological health using the Geriatric Depression Scale (GDS). Knee pain and physical function were assessed using the Japanese Knee Osteoarthritis Measure (JKOM), 10-m walk, timed up and go (TUG), and five-repetition chair stand tests. Results: Ordinal logistic regression analysis showed that depression, defined as a GDS score≥5 points, was significantly associated with a worse score on the JKOM pain-subcategory and a higher level of task-specific knee pain intensity during daily living, after being adjusted for age, sex, body mass index (BMI), K/L grade, and ambulatory physical activity. Furthermore, depression was significantly associated with a slower gait velocity and a longer TUG time, after adjusting for age, sex, BMI, K/L grade, presence of bilateral knee pain, and ambulatory physical activity. Conclusions: These findings indicate that depression may be associated with increased knee pain intensity during daily living in a non-task-specific manner and is associated with functional limitation in patients with knee OA, even after controlling for covariates, including bilateral knee pain and ambulatory physical activity.

    DOI: 10.1186/s40359-018-0234-3

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  35. Biomechanical characteristics of stair ambulation in patients with knee OA: A systematic review with meta-analysis toward a better definition of clinical hallmarks. 国際誌

    Hirotaka Iijima, Kanako Shimoura, Tomoki Aoyama, Masaki Takahashi

    Gait & posture   62 巻   頁: 191 - 201   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Stair climbing was suggested to be the first affected task in individuals with knee osteoarthritis (OA). RESEARCH QUESTION: This review aimed to identify consistent kinematic, kinetic, and spatiotemporal alterations of stair climbing exhibited by individuals with knee OA. METHODS: A literature search published until September 2017 was conducted in PubMed, PEDro, CINAHL, and Cochrane CENTRAL. Reviewer extracted data in accordance with the Cochrane Handbook. Where possible, data were combined into a meta-analysis; the pooled standardized mean differences between individuals with knee OA and healthy adults were calculated using the random-effect model. RESULTS: In total, 585 potentially relevant articles were selected, of which 12 (695 participants, mean age: 58.4 years) met the inclusion criteria. Meta-analysis revealed that kinematic and kinetic alterations during stair climbing associated with knee OA were lower external knee flexion moment in conjunction with a larger trunk/hip flexion angles and smaller knee flexion/ankle dorsiflexion angles. Individuals with knee OA showed a delayed quadriceps activation during stair ascent. A lack of evidence was detected for alterations in external knee adduction moment during stair climbing. Effect estimate in each meta-analysis was judged "very low" on the GRADE approach. SIGNIFICANCE: No strong conclusion can be drawn because of the low quality of evidence; however, individuals with knee OA may exhibit altered kinematics and kinetics changes in sagittal plane during stair climbing, and have delayed quadriceps muscle activity. Further studies with adequate adjustment for confounders are warranted to facilitate clinical hallmarks of the knee OA, particularly in early stages of the disease.

    DOI: 10.1016/j.gaitpost.2018.03.002

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  36. Varus thrust visualized during gait was associated with inverted foot in patients with knee osteoarthritis: An exploratory study 国際誌

    Ohi Hiroshi, Iijima Hirotaka, Fukutani Naoto, Aoyama Tomoki, Kaneda Eishi, Ohi Kazuko, Ito Hiromu, Matsuda Shuichi, Kaoru Abe

    GAIT & POSTURE   61 巻   頁: 269 - 275   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Gait and Posture  

    The foot is speculated to play a role in knee joint kinematics. This exploratory cross-sectional study examined the association between static foot posture and the presence of varus thrust visualized during gait in patients with medial knee osteoarthritis (OA). Patients (n = 88 patients and 134 knees; age, 61–91 years; 68.2% female) with Kellgren/Lawrence (K/L) grade ≥1 in the medial compartment were included in this study and underwent gait observation for varus thrust. These patients’ three-dimensional static foot posture while standing was evaluated and their tibiofemoral joint K/L grades and anatomical axis angles were also assessed as covariates. Knees with varus thrust (22 knees, 16.4%) on average had a 4° more inverted calcaneus relative to the floor than those without varus thrust (P < 0.001). A logistic regression analysis showed that an increased calcaneus inversion angle was significantly associated with higher odds of the presence of varus thrust with adjustments for age, sex, body mass index, K/L grade, and anatomical axis angle. The other predictors, such as navicular height, navicular height/foot length, and rearfoot angle relative to the lower leg, were not significantly associated with varus thrust. These results suggest that patients with varus thrust had a different static rearfoot posture as compared with those without varus thrust, a finding that may indicate an important role of static rearfoot posture in the pathogenesis of varus thrust. Furthermore, investigating the potential influence of foot posture on the efficacy of biomechanical interventions, such as lateral wedge insole use, on varus thrust would be of particular interest in the further studies.

    DOI: 10.1016/j.gaitpost.2018.01.020

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  37. Inverted Rearfoot posture in subjects with coexisting patellofemoral osteoarthritis in medial knee osteoarthritis: an exploratory study 国際誌

    Iijima Hirotaka, Ohi Hiroshi, Fukutani Naoto, Aoyama Tomoki, Kaneda Eishi, Abe Kaoru, Takahashi Masaki, Matsuda Shuichi

    JOURNAL OF FOOT AND ANKLE RESEARCH   11 巻 ( 1 ) 頁: 17 - 17   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Foot and Ankle Research  

    Background: While abnormal rearfoot posture and its relationship to patellofemoral (PF) pain has been thoroughly discussed in the literature, its relationship to patellofemoral osteoarthritis (PFOA) has not been determined. This study aimed to examine whether rearfoot posture is associated with a higher prevalence of radiographic PFOA in a compartment-specific manner in patients with medial tibiofemoral osteoarthritis (TFOA). Methods: Participants from orthopedic clinics (n=68, age 56-90 years, 75.0% female), diagnosed with radiographic medial TFOA (Kellgren/Lawrence [K/L] grade≥2) were included in this study. The presence of PFOA and static rearfoot posture were evaluated using a radiographic skyline view and a footprint automatic measurement apparatus, respectively. The relationship between rearfoot posture and PFOA was examined using analysis of covariance and propensity score-adjusted logistic regression analysis. Results: On average, patients with coexisting PFOA and medial TFOA (n=39) had an inverted calcaneus 3.1° greater than those with isolated medial TFOA (n=29). Increased calcaneus inverted angle was significantly associated with a higher probability of the presence of medial PFOA (odds ratio: 1.180, 95% confidence interval: [1.005, 1.439]; p=0.043). Calcaneus inverted angle was not associated with higher odds of lateral PFOA presence based on the adjusted values. Conclusions: The presence of an inverted rearfoot was associated with PFOA. Although these findings do not clearly indicate a biomechanical link between rearfoot posture and PFOA, this study shed light on the potential relationship between altered rearfoot posture and PFOA, as can be seen between rearfoot abnormality and PF pain.

    DOI: 10.1186/s13047-018-0261-6

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  38. Postpartum radiographic changes in pelvic morphology and its relation with symptoms of pregnancy-related symphysis pain

    Ji X., Takahashi M., Morino S., Takakuwa T., Iijima H., Zhang X., Ishihara M., Kawagoe M., Hatanaka Y., Umezaki F., Yamashita M., Tsuboyama T., Aoyama T.

    CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY   45 巻 ( 5 ) 頁: 665 - 670   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical and Experimental Obstetrics and Gynecology  

    Introduction: The etiology of pregnancy-related pubic symphysis pain (PSP) is usually considered as the change in pelvic biomechanics during pregnancy. However, the biomechanical changes that occur during puerperium, and the difference of radiographic dimensions in women with different types of PSP remains unknown. Materials and Methods: Fifty women with self-reported PSP were included. Two conventional X-ray radiographic dimensions obtained on the delivery day and one-month postpartum were compared by using paired t-test. Based on the self-reported VAS at one-month postpartum, variables between pain-recovery and non-recovery groups were also compared. Results: The comparison between pre- and post-values indicates a reduced distance between FLAMs (239.1 vs. 237.0 mm), PS separation (7.9 vs. 6.5 mm), and PS translation (4.1 vs. 3.1 mm). No significant differences were observed in the distance between FLAMs, width of PS separation, or pubic symphysial surface (PSS) angle between the recovery and non-recovery groups. However, the non-recovery group exhibited a significantly large change in PS translation at one-month postpartum than the recovery group (-1.8 vs. -1.1 mm). Conclusions: The pelvic radiography demonstrated a 'closure' alteration in the pelvic cavity diameter one-month postpartum with a decrease in the distance between FLAMs and shortened PS separation. The difference in radiographic diameters between groups was not clearly evident.

    DOI: 10.12891/ceog3964.2018

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  39. Comparison of the effects of kilohertz- and low-frequency electric stimulations: A systematic review with meta-analysis. 国際誌

    Hirotaka Iijima, Masaki Takahashi, Yuto Tashiro, Tomoki Aoyama

    PloS one   13 巻 ( 4 ) 頁: e0195236   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: This study aimed to determine whether kilohertz-frequency alternating current (KFAC) is superior to low-frequency pulsed current (PC) in increasing muscle-evoked torque and lessening discomfort. DATA SOURCES: The electronic databases PubMed, PEDro, CINAHL, and CENTRAL were searched for related articles, published before August 2017. Furthermore, citation search was performed on the original record using Web of Science. REVIEW METHODS: Randomized controlled trials, quasi-experimental studies, and within-subject repeated studies evaluating and comparing KFAC and PC treatments were included. The pooled standardized mean differences (SMDs) of KFAC and PC treatments, with 95% confidence intervals (CIs), were calculated using the random effects model. RESULTS: In total, 1148 potentially relevant articles were selected, of which 14 articles with within-subject repeated designs (271 participants, mean age: 26.4 years) met the inclusion criteria. KFAC did not significantly increase muscle-evoked torque, compared to PC (pooled SMD: -0.25; 95% CI: -0.53, 0.06; P = 0.120). KFAC had comparable discomfort compared to that experienced using PC (pooled SMD: -0.06; 95% CI: -0.50, 0.38; P = 0.800). These estimates of the effects had a high risk of bias, as assessed using the Downs and Black scale, and were highly heterogeneous studies. CONCLUSIONS: This meta-analysis does not establish that KFAC is superior to PC in increasing muscle-evoked torque and lessening discomfort level. However, no strong conclusion could be drawn because of a high risk of bias and a large amount of heterogeneity. High quality studies comparing the efficacy between PC and KFAC treatments with consideration of potential confounders is warranted to facilitate the development of effective treatment.

    DOI: 10.1371/journal.pone.0195236

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  40. Effectiveness of mesenchymal stem cells for treating patients with knee osteoarthritis: a meta-analysis toward the establishment of effective regenerative rehabilitation. 国際誌

    Hirotaka Iijima, Takuya Isho, Hiroshi Kuroki, Masaki Takahashi, Tomoki Aoyama

    NPJ Regenerative medicine   3 巻   頁: 15 - 15   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This systematic review with a meta-analysis aimed to summarize the current evidence of the effectiveness of mesenchymal stem cell (MSC) treatment for knee osteoarthritis (OA) and to examine whether rehabilitation is an effect modifier of the effect estimate of MSC treatment. A literature search yielded 659 studies, of which 35 studies met the inclusion criteria (n = 2385 patients; mean age: 36.0-74.5 years). The meta-analysis results suggested that MSC treatment through intra-articular injection or arthroscopic implantation significantly improved knee pain (standardized mean difference [SMD]: -1.45, 95% confidence interval [CI]: -1.94, -0.96), self-reported physical function (SMD: 1.50, 95% CI: 1.09, 1.92), and cartilage quality (SMD: -1.99; 95% CI: -3.51, -0.47). However, the MSC treatment efficacy on cartilage volume was limited (SMD: 0.49; 95% CI: -0.19, 1.16). Minor adverse events (knee pain or swelling) were reported with a wide-ranging prevalence of 2-60%; however, no severe adverse events occurred. The evidence for these outcomes was "very low" to "low" according to the Grades of Recommendation, Assessment, Development and Evaluation system because of the poor study design, high risk of bias, large heterogeneity, and wide 95% CI of the effects estimate. Performing rehabilitation was significantly associated with better SMD for self-reported physical function (regression coefficient: 0.881, 95% CI: 0.049, 1.712; P = 0.039). We suggest that more high quality randomized controlled trials with consideration of the potential rehabilitation-driven clinical benefit would be needed to facilitate the foundation of effective MSC treatment and regenerative rehabilitation for patients with knee OA.

    DOI: 10.1038/s41536-018-0041-8

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  41. Association of bilateral flat feet with knee pain and disability in patients with knee osteoarthritis: A cross-sectional study. 国際誌

    Hirotaka Iijima, Hiroshi Ohi, Takuya Isho, Tomoki Aoyama, Naoto Fukutani, Eishi Kaneda, Kazuko Ohi, Kaoru Abe, Hiroshi Kuroki, Shuichi Matsuda

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society   35 巻 ( 11 ) 頁: 2490 - 2498   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This cross-sectional study examined the relationship of flat feet with knee pain, disability, and physical performance in patients with knee osteoarthritis (OA). Orthopedic clinic participants (n = 95; age 61-91 years; 68.4% women) with Kellgren-Lawrence (K/L) grade ≥1 in the medial compartment underwent evaluation of navicular height and foot length for flat feet. Knee pain intensity, disability, and physical performance were evaluated using the Japanese Knee Osteoarthritis Measure, 10-m walk, timed up and go, and five-repetition chair stand tests. Of the 95 enrolled patients, 24 (25.3%) had bilateral flat feet, and significantly higher knee pain compared to patients with no flat feet (11.3 ± 8.23 points vs. 6.58 ± 6.37 points; p = 0.043). A ordinal logistic regression analysis showed that bilateral flat feet were significantly associated with increased knee pain (proportional odds ratio: 5.48, 95% confidence interval: 1.96, 15.3; p = 0.001) compared with no flat feet, adjusted for age, sex, body mass index, and tibiofemoral joint K/L grade, which is consistent across various different cutoffs of the definition of flat feet. Physical performance was similar between patients with and without bilateral flat feet. The presence of unilateral flat feet was not significantly associated with any outcome measures. These findings indicate that bilateral, but not unilateral, flat feet are associated with worse knee pain. A prospective study investigating a causal relationship between bilateral flat feet posture and knee pain as well as disability would be of particular interest to verify the potential adverse effect of altered foot posture. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2490-2498, 2017.

    DOI: 10.1002/jor.23565

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  42. Low back pain and causative movements in pregnancy: a prospective cohort study 国際誌

    Morino Saori, Ishihara Mika, Umezaki Fumiko, Hatanaka Hiroko, Iijima Hirotaka, Yamashita Mamoru, Aoyama Tomoki, Takahashi Masaki

    BMC MUSCULOSKELETAL DISORDERS   18 巻 ( 1 ) 頁: 416 - 416   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC Musculoskeletal Disorders  

    Background: Low back pain (LBP) during pregnancy might be strongly related to posture and movements of the body, and its management is a clinically important issue. The purpose of this study was to investigate the activities related to LBP during pregnancy. Methods: Participants included 275 women before 12 weeks of pregnancy. The women were evaluated at 12, 24, 30, and 36 weeks of pregnancy. The intensity of LBP was assessed using the Numerical Rating Scale (NRS). Movements related to LBP were investigated by free descriptive answers. Descriptive statistics were used to compile the movements that pregnant women thought induced LBP at each evaluation. Subsequently, a linear regression analysis was performed to evaluate the degree of association of certain movements with LBP using the data of participants who had LBP. The intensity of LBP (NRS score) was specified as the dependent variable, the movements that were related to pain were specified as the independent variables at the analysis. A significance threshold was set at 0.05. Results: The final sample used in the analyses was 254, 249, 258, and 245 women at 12, 24, 30, and 36 weeks of pregnancy, respectively. There were 16 kinds of movements that induced LBP and all of them were daily activities rather than special movements that require extra task or effort. As pregnancy progressed, less number of participants attributed pain to a specific movement. At all evaluations, movements, especially sitting up, standing up from a chair, and tossing and turning were thought to be related to LBP. Furthermore, standing up from a chair and tossing and turning were significantly related to LBP throughout the pregnancy. In contrast, lying down and sitting up were significantly related to LBP but the relationship did not continue till late pregnancy. Conclusions: Daily routine activity is related to LBP during pregnancy. These results suggest that recommendations for pregnant women about basic physical movements, such as ways of standing up that reduce the load on the body might be useful in the management of LBP.

    DOI: 10.1186/s12891-017-1776-x

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  43. Association of varus thrust with prevalent patellofemoral osteoarthritis: A cross-sectional study. 国際誌

    Hirotaka Iijima, Naoto Fukutani, Yuko Yamamoto, Masakazu Hiraoka, Kazuyuki Miyanobu, Masashi Jinnouchi, Eishi Kaneda, Takuya Isho, Tomoki Aoyama, Hiroshi Kuroki, Shuichi Matsuda

    Gait & posture   58 巻   頁: 394 - 400   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This cross-sectional study investigated (i) the association of varus thrust during gait with the presence of patellofemoral osteoarthritis (PFOA) in patients with medial knee osteoarthritis (OA) and (ii) patellar alignment in the knees with varus thrust. Participants from orthopedic clinics (n=171; mean age, 73.4 years; 71.9% female) diagnosed with radiographic medial knee OA (Kellgren/Lawrence [K/L] grade ≥1) were included in this study, and underwent gait observation for varus thrust assessment using 2D video analysis. A radiographic skyline view was used to assess the presence of medial PFOA using the grading system from the Osteoarthritis Research Society International Atlas. The tibiofemoral joint K/L grade, patellar alignment (i.e., lateral shift and tilting angle), and knee pain intensity were also evaluated as covariates. Thirty-two (18.7%) of 171 patients exhibited varus thrust and they presented significantly higher knee pain (46.0±3.04mm vs. 32.4±2.73mm; P=0.024), a lower patellar tilting angle (P=0.024), and a higher prevalence of PFOA compared with those without varus thrust. A logistic regression analysis with adjustment of covariates showed that varus thrust was significantly associated with higher odds of the presence of mixed and medial PFOA, and trended to significantly associate with any PFOA, including lateral PFOA. This indicates that varus thrust was associated with PFOA in a compartment-nonspecific manner in patients with medial knee OA. Varus thrust may represent a clinical disease feature of more advanced and multicompartmental disease.

    DOI: 10.1016/j.gaitpost.2017.08.033

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  44. Coexisting lateral tibiofemoral osteoarthritis is associated with worse knee pain in patients with mild medial osteoarthritis. 国際誌

    H Iijima, T Aoyama, K Nishitani, H Ito, N Fukutani, T Isho, E Kaneda, H Kuroki, S Matsuda

    Osteoarthritis and cartilage   25 巻 ( 8 ) 頁: 1274 - 1281   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To examine the clinical impact of coexisting lateral osteoarthritis (OA) in knees with mild medial OA. DESIGN: In patients with Kellgren/Lawrence (K/L) grade 2 OA in the medial compartment (n = 100; age: 56-89 years; 80.0% female), anteroposterior knee radiography was used to assess the presence of lateral OA, using grading systems from the Osteoarthritis Research Society International (OARSI) atlas and the K/L classification. The Japanese Knee Osteoarthritis Measure (JKOM), knee range of motion (ROM), and performance-based functional measures (10 m walk, timed up and go and five repetition chair stand maneuvers) were evaluated. The outcomes were compared between patients with and without lateral OA using an analysis of covariance (ANCOVA) or nonparametric rank ANCOVA. Furthermore, ordinal logistic regression analysis was performed, with responses on individual JKOM pain questionnaires as the outcomes and lateral OA as the predictor. RESULTS: Knees with coexisting lateral OA had a significantly worse score of JKOM pain question compared with those without, after adjusting for covariates. The presence of lateral OA was significantly associated with knee pain while ascending/descending stairs and standing. These results were consistent between different definitions of the K/L and OARSI grading systems. The knee ROM and performance-based functional measures were not significantly different between patients with and without lateral OA. CONCLUSION: Knees with concomitant lateral and mild medial OA may be more symptomatic compared to those without lateral OA. These findings might help to define a clinically distinct subgroup based on a simple radiographic finding in mild knee OA.

    DOI: 10.1016/j.joca.2017.02.801

    PubMed

  45. Relationship Between Pedometer-Based Physical Activity and Physical Function in Patients With Osteoarthritis of the Knee: A Cross-Sectional Study 国際誌

    Iijima Hirotaka, Fukutani Naoto, Isho Takuya, Yamamoto Yuko, Hiraoka Masakazu, Miyanobu Kazuyuki, Jinnouchi Masashi, Kaneda Eishi, Aoyama Tomoki, Kuroki Hiroshi, Matsuda Shuichi

    ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION   98 巻 ( 7 ) 頁: 1382 - 1388   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Archives of Physical Medicine and Rehabilitation  

    Objective To examine the association between pedometer-based ambulatory physical activity (PA) and physical function in patients with knee osteoarthritis (OA). Design Cross-sectional observational study. Setting Institutional practice. Participants Participants in orthopedic clinics (N=207; age, 56–90y; 71.5% women) with diagnosed radiographic knee OA (Kellgren/Lawrence [K/L] grade ≥1). Interventions Not applicable. Main Outcome Measures Ambulatory PA was objectively measured as steps per day. Physical function was assessed using the Japanese Knee Osteoarthritis Measure (JKOM) functional subcategory, 10-m walk, Timed Up and Go (TUG), and 5-repetition chair stand (5CS) tests. Results Patients walking <2500 steps/d had a low level of physical function with a slower gait speed, longer TUG time, and worse JKOM functional score compared with those who walk 2500 to 4999, 5000 to 7499, and ≥7500 steps/d adjusted for age, sex, body mass index [BMI], and K/L grade. Ordinal logistic regression analysis revealed that steps per day (continuous) was associated with better physical function adjusted for age, sex, BMI, and K/L grade. These relationships were still robust in sensitivity analyses that included patients with K/L grades ≥2 (n=140). Conclusions Although increased ambulatory PA had a positive relationship with better physical function, walking <2500 steps/d may be a simple indicator for a decrease in physical function in patients with knee OA among standard PA categories. Our findings might be a basis for counseling patients with knee OA about their ambulatory PA and for developing better strategies for improving physical function in sedentary patients with knee OA.

    DOI: 10.1016/j.apmr.2016.12.021

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  46. Association of frontal plane knee alignment with foot posture in patients with medial knee osteoarthritis. 国際誌

    Hiroshi Ohi, Hirotaka Iijima, Tomoki Aoyama, Eishi Kaneda, Kazuko Ohi, Kaoru Abe

    BMC musculoskeletal disorders   18 巻 ( 1 ) 頁: 246 - 246   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: To examine the association of radiographic frontal plane knee alignment with three-dimensional foot posture in patients with medial knee osteoarthritis (OA). METHODS: Participants in orthopedic clinics with Kellgren/Lawrence (K/L) grade ≥1 (88 patients and 88 knees; age, 61-91 years; 65.9% female) were enrolled. An anteroposterior radiographic view was used to assess the anatomical axis angle (AAA) after subtracting a sex-specific correction factor. The three-dimensional foot posture was also evaluated. RESULTS: Multiple regression analyses showed that increased corrected AAA (i.e., valgus direction) was independently associated with a decrease in the hallux valgus angle (regression coefficient: -0.40 per degree, 95% confidence interval [CI]: -0.72, -0.09; P = 0.013) and increase in the pronation angle of the calcaneus relative to floor (regression coefficient: 0.33 per degree, 95% CI: 0.10, 0.56; P = 0.005) adjusted for age, sex, and body mass index. The relationship between the corrected AAA and hallux valgus angle strengthened (regression coefficient: -0.60 per degree, 95% CI: -1.08, -0.13; P = 0.014) in varus-aligned knees examined separately (63 knees). The other foot postures (navicular height, navicular height/foot length, and rearfoot angle) were not significantly associated with corrected AAA. CONCLUSIONS: Radiographic frontal plane knee alignment was associated with hallux valgus angle and calcaneus angle relative to the floor in patients with medial knee OA, particularly in varus-aligned knees. These results indicate a connection between altered frontal knee alignment and foot posture, which may be helpful in understanding the pathogenesis of altered foot posture observed in patients with knee OA.

    DOI: 10.1186/s12891-017-1588-z

    PubMed

  47. Pathohistological investigation of osteochondral tissue obtained during total knee arthroplasty after osteochondral autologous transfer: a case report 国際誌

    Tanima-Nagai M., Harada H., Aoyama T., Yamaguchi S., Ito A., Tajino J., Iijima H., Zhang X., Kuroki H., Kobayashi M.

    BMC Research Notes   10 巻 ( 1 ) 頁: 194 - 194   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC Research Notes  

    Background: Osteochondral autologous transfer is one of the repair techniques for cartilage defects of knee with promising knee function recovery. There are no reports including histopathological images concerning human osteochondral tissue after osteochondral autologous transfer. This is the first report to present pathohistological findings of transplanted plugs and host tissues extracted from the human body 3 years after osteochondral autologous transfer. This study aimed to explore the cause factor of chronic pain using histological techniques. Case presentation: A 67-year-old Japanese man presented with adjusted total knee arthroplasty 3 years after osteochondral autologous transfer. Although in pain, arthroscopic assessment was not severe. The specimens which was gained during total knee arthroplasty were investigated in gross and microscopically using immunohistochemical staining technic. Histological examination revealed that the gap between grafted plugs and host osteochondral tissues was filled with fibrous tissue that stained positive for type I collagen. A degenerative change and some neovascularity were observed in the regenerated tissue and host trabecular bone. Furthermore, cysts and bone marrow edema were observed. Conclusion: Our data suggests that the host osteochondral morbidity around grafted plugs might be related to chronical pain and revision surgery.

    DOI: 10.1186/s13104-017-2513-0

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  48. Physiological exercise loading suppresses post-traumatic osteoarthritis progression via an increase in bone morphogenetic proteins expression in an experimental rat knee model 国際誌

    Iijima H., Ito A., Nagai M., Tajino J., Yamaguchi S., Kiyan W., Nakahata A., Zhang J., Wang T., Aoyama T., Nishitani K., Kuroki H.

    OSTEOARTHRITIS AND CARTILAGE   25 巻 ( 6 ) 頁: 964 - 975   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Osteoarthritis and Cartilage  

    Objective To evaluate the dose–response relationship of exercise loading in the cartilage-subchondral bone (SB) unit in surgically-induced post-traumatic osteoarthritis (PTOA) of the knee. Design Destabilized medial meniscus (DMM) surgery was performed on the right knee of 12-week-old male Wistar rats, and sham surgery was performed on the contralateral knee. Four weeks after the surgery, the animals were subjected to moderate (12 m/min) or intense (21 m/min) treadmill exercises for 30 min/day, 5 days/week for 4 weeks. PTOA development in articular cartilage and SB was examined using histological and immunohistochemical analyses, micro-computed tomography (micro-CT) analysis, and biomechanical testing at 8 weeks after surgery. Gremlin-1 was injected to determine the role of bone morphogenetic protein (BMP) signaling on PTOA development following moderate exercise. Results Moderate exercise increased BMP-2, BMP-4, BMP-6, BMP receptor 2, pSmad-5, and inhibitor of DNA binding protein-1 expression in the superficial zone chondrocytes and suppressed cartilage degeneration, osteophyte growth, SB damage, and osteoclast-mediated SB resorption. However, intense exercise had little effect on BMP expression and even caused progression of these osteoarthritis (OA) changes. Gremlin-1 injection following moderate exercise caused progression of the PTOA development down to the level of the non-exercise DMM-operated knee. Conclusions Exercise regulated cartilage-SB PTOA development in DMM-operated knees in a dose-dependent manner. Our findings shed light on the important role of BMP expression in superficial zone chondrocytes in attenuation of PTOA development following physiological exercise loading. Further studies to support a mechanism by which BMPs would be beneficial in preventing PTOA progression are warranted.

    DOI: 10.1016/j.joca.2016.12.008

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  49. Changes in clinical symptoms and functional disability in patients with coexisting patellofemoral and tibiofemoral osteoarthritis: a 1-year prospective cohort study. 国際誌

    Hirotaka Iijima, Naoto Fukutani, Takuya Isho, Yuko Yamamoto, Masakazu Hiraoka, Kazuyuki Miyanobu, Masashi Jinnouchi, Eishi Kaneda, Tomoki Aoyama, Hiroshi Kuroki, Shuichi Matsuda

    BMC musculoskeletal disorders   18 巻 ( 1 ) 頁: 126 - 126   2017年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: This 1-year prospective cohort study aimed to compare the changes in clinical symptoms and functional disability between patients with coexisting patellofemoral (PF) and tibiofemoral (TF) osteoarthritis (OA) and those with isolated TFOA. METHODS: Seventy-two patients with medial knee OA were enrolled. Knee pain and functional disability were assessed at baseline and at 1-year follow-up using the Japanese Knee Osteoarthritis Measure (JKOM) and a visual analog scale (VAS). We performed two-way analysis of covariance for the clinical outcome variables to examine, time (baseline and follow-up), group (coexisting PFOA and isolated TFOA), and time-group interaction effects. Furthermore, we conducted post-hoc exploratory analysis to address the possibility that dividing patients according to location of PFOA (i.e., isolated lateral, isolated medial, and mixed [bilateral]) may identify a distinct subgroup with different changes in clinical outcomes at 1-year follow-up. RESULTS: We detected group effects only in scores of the JKOM pain subscale (P = 0.012) and VAS (P = 0.033), adjusted for age, sex, and body mass index. Patients with coexisting PFOA have stable moderate level knee pain and functional disability throughout the year which is significantly worse than that in those with isolated TFOA. Post-hoc subgroup analysis demonstrated that change of knee pain likely varied with location of PFOA. Patients with isolated lateral PFOA had mild/moderate level knee pain, and their VAS scores were likely to improve, whereas those with mixed PFOA exhibited stable to worsening moderate/severe knee pain. CONCLUSIONS: Although we did not detect differences in changes in clinical symptoms and functional disability between patients with coexisting PFOA and those with isolated TFOA, our findings indicate that patients with coexisting PFOA had worse clinical symptoms and functional disability than those with isolated TFOA. The results of the exploratory analysis suggested that patients with coexisting PFOA might have heterogeneous clinical outcomes, and presence of mixed PFOA might be an indicator of severe clinical knee OA.

    DOI: 10.1186/s12891-017-1486-4

    PubMed

  50. Effect of Low-Intensity Pulsed Ultrasound after Mesenchymal Stromal Cell Injection to Treat Osteochondral Defects: An In Vivo Study. 国際誌

    Shoki Yamaguchi, Tomoki Aoyama, Akira Ito, Momoko Nagai, Hirotaka Iijima, Junichi Tajino, Xiangkai Zhang, Kiyan Wataru, Hiroshi Kuroki

    Ultrasound in medicine & biology   42 巻 ( 12 ) 頁: 2903 - 2913   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We investigated the effect of low-intensity pulsed ultrasound (LIPUS) treatment combined with mesenchymal stromal cell (MSC) injection for cartilage repair and subchondral bone reconstitution for treatment of osteochondral defects. An osteochondral defect was created on both femur grooves of Wistar rats. Four weeks later, bone marrow MSCs were injected into the right knee joint. The rats were divided into two intervention groups: without or with LIPUS irradiation. Cartilage repair was evaluated histologically based on the Wakitani cartilage repair score. Subchondral bone reconstitution was evaluated as bone volume (BV)/tissue volume (TV) by micro-computed tomography analysis. MSC injection improved the cartilage repair score, and LIPUS irradiation improved BV/TV. Combination treatment promoted both cartilage repair and BV/TV improvement. Thus, MSC injection combined with LIPUS irradiation is more effective than either treatment alone in promoting concurrent cartilage repair and subchondral reconstitution.

    DOI: 10.1016/j.ultrasmedbio.2016.07.021

    PubMed

  51. Knee pain during activities of daily living and its relationship with physical activity in patients with early and severe knee osteoarthritis 国際誌

    Fukutani Naoto, Iijima Hirotaka, Aoyama Tomoki, Yamamoto Yuko, Hiraoka Masakazu, Miyanobu Kazuyuki, Jinnouchi Masashi, Kaneda Eishi, Tsuboyama Tadao, Matsuda Shuichi

    CLINICAL RHEUMATOLOGY   35 巻 ( 9 ) 頁: 2307 - 16   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical Rheumatology  

    This study aimed to investigate whether knee pain during various activities of daily living (ADLs) is associated with physical activity in patients with early and severe knee osteoarthritis (OA). We hypothesized that the painful ADLs associated with decreased physical activity differ according to disease severity. This cross-sectional study enrolled 270 patients with medial knee OA, assigned to either the early (Kellgren Lawrence [K/L] grade 1–2) or the severe group (K/L grade 3–4). Physical activity was assessed using a pedometer. Knee pain during six ADLs (waking up in the morning, walking on a flat surface, ascending stairs, etc.) was evaluated using a questionnaire. We performed multiple regression and quantile regression analysis to investigate whether knee pain during each ADL was associated with physical activity. In the early group, the more knee pain they experienced while ascending stairs, the lower their physical activity was (75th regression coefficient = −1033.70, P = 0.018). In the severe group, the more knee pain they experienced while walking on a flat surface or bending to the floor or standing up, the lower their physical activity was (unstandardized coefficients = −1850.87, P = 0.026; unstandardized coefficients = −2640.35, P = 0.010). Knee pain while ascending stairs and while walking on a flat surface or bending to the floor or standing up was a probable limiting factor for physical activity in early and severe knee OA, respectively. These findings suggested that a reduction in task-specific knee pain according to disease severity could improve physical activity levels.

    DOI: 10.1007/s10067-016-3251-8

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  52. Remobilization causes site-specific cyst formation in immobilization-induced knee cartilage degeneration in an immobilized rat model 国際誌

    Nagai Momoko, Ito Akira, Tajino Junichi, Iijima Hirotaka, Yamaguchi Shoki, Zhang Xiangkai, Aoyama Tomoki, Kuroki Hiroshi

    JOURNAL OF ANATOMY   228 巻 ( 6 ) 頁: 929 - 39   2016年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Anatomy  

    An understanding of the articular cartilage degenerative process is necessary for the prevention and treatment of joint disease. The present study aimed to examine how long-term immobilization-induced cartilage degeneration is aggravated by remobilization. Sixty 8-week-old male Wistar rats were used in this study. The unilateral knee joint was immobilized using an external fixator for 8weeks. The rats were killed at 0 and 3days, and at 1, 2, 4 and 8weeks after removing the fixator. After the rats were killed, the maximum knee extension angles were measured. Histological sections at the medial mid-condylar region (non-contact, transitional and contact regions of the femur and tibia) were prepared and scored. The cartilage thickness and number of chondrocytes were measured, and CD44 and Col2-3/4c expression levels were assessed immunohistochemically. The histological assessment revealed progressive aggravation of cartilage degeneration in the transitional region, with a decreased number of chondrocytes and CD44-positive chondrocytes as well as poor scoring over time, particularly in the tibia. Cyst formation was confirmed in the transitional region of the tibia at 8weeks post-remobilization. The cartilage thickness in the transitional region was thicker than that in the contact region, particularly in the tibia. Col2-3/4c expression was observed in the non-contact and transitional regions, and the knee extension angle was recovered. In conclusion, immobilization-induced cartilage degeneration was aggravated by remobilization over time in the transitional region, followed by observations of a decreased number of chondrocytes and morphological disparity between different cartilage regions.

    DOI: 10.1111/joa.12453

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  53. Exercise intervention increases expression of bone morphogenetic proteins and prevents the progression of cartilage-subchondral bone lesions in a post-traumatic rat knee model. 国際誌

    H Iijima, T Aoyama, A Ito, J Tajino, S Yamaguchi, M Nagai, W Kiyan, X Zhang, H Kuroki

    Osteoarthritis and cartilage   24 巻 ( 6 ) 頁: 1092 - 102   2016年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: This study aimed to determine whether treadmill walking (TW) prevents the progression of post-traumatic osteoarthritic changes in cartilage-subchondral bone unit, and whether the exercise timing changes the exercise efficacy in destabilized medial meniscus (DMM) rat knees. DESIGN: Twelve-week-old male Wistar rats underwent DMM surgery on their right knees and sham surgery on their left knees and were assigned to either the sedentary (n = 10) or walking (n = 24) groups. The rats in the walking group were subjected to TW from day 2 through 4 weeks, from 4 through 8 weeks, or from day 2 through 8 weeks (n = 8 per group). Osteoarthritic changes of cartilage and subchondral bone were assessed with micro-computed tomography, histology, and immunohistochemistry 8 weeks after surgery. RESULTS: TW prevented the progression of cartilage and subchondral bone lesions induced by the DMM, and increased bone morphogenetic protein (BMP)-2 and -6 expressions in superficial zone chondrocytes and bone-lining cells including osteoblasts. Furthermore, the TW-induced increase in BMPs varied with the exercise timing. Beginning TW 4 weeks after DMM surgery was the best option for increasing BMPs, coinciding with the most robust prevention of osteoarthritic changes. CONCLUSIONS: TW increased the expression of BMPs and prevented the progression of cartilage-subchondral bone lesions in rat knees with a DMM. Selective exercise timing may be a key factor in the development of an exercise regimen for preventing the progression of post-traumatic osteoarthritis (PTOA). Furthermore, exercise may have favorable effects even after the PTOA has been developed.

    DOI: 10.1016/j.joca.2016.01.006

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  54. Clinical Impact of Coexisting Patellofemoral Osteoarthritis in Japanese Patients With Medial Knee Osteoarthritis. 国際誌

    Hirotaka Iijima, Naoto Fukutani, Tomoki Aoyama, Takahiko Fukumoto, Daisuke Uritani, Eishi Kaneda, Kazuo Ota, Hiroshi Kuroki, Shuichi Matsuda

    Arthritis care & research   68 巻 ( 4 ) 頁: 493 - 501   2016年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To evaluate the clinical impact in knee osteoarthritis (OA) of coexisting patellofemoral (PF) joint OA (PFOA) in Japanese patients with medial tibiofemoral (TF) joint OA (TFOA). METHODS: Patients with medial knee OA (n = 143) were enrolled. The radiographic severity of the TF and PF joints, anatomic axis angle of the TF joint, patellar alignment, trochlear morphology, patellar height, and passive range of motion (ROM) of the painful knee were evaluated. Additionally, the Japanese Knee Osteoarthritis Measure (JKOM) was used to investigate the association between the presence of PFOA and clinical symptoms. RESULTS: PFOA was present in 98 of 143 patients (68.5%) with medial knee OA. Quantile regression analysis revealed that coexisting PFOA was associated with the pain-related subcategory of the JKOM. Furthermore, multiple logistic regression analysis showed that coexisting PFOA was associated with higher odds of reporting knee pain on using stairs while ascending (odds ratio [OR] 4.81 [95% confidence interval (95% CI) 1.73, 14.3]) and descending (OR 3.86 [95% CI 1.44, 10.8]). A more varus knee alignment and lower knee flexion ROM, which are features of patients with coexisting PFOA, were associated with knee pain while ascending/descending stairs. However, patellar alignment, trochlear morphology, and patellar height were not significantly associated with knee pain. CONCLUSION: PFOA coexisting with medial knee OA was associated with worse clinical symptoms, particularly while ascending/descending stairs, although patellar alignment did not contribute to reporting knee pain. Further studies that include evaluation of the PF joint are warranted to develop a basis for an optimal intervention based on compartmental involvement.

    DOI: 10.1002/acr.22691

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  55. The Effect of Exercise on the Early Stages of Mesenchymal Stromal Cell-Induced Cartilage Repair in a Rat Osteochondral Defect Model

    Yamaguchi Shoki, Aoyama Tomoki, Ito Akira, Nagai Momoko, Iijima Hirotaka, Tajino Junichi, Zhang Xiangkai, Kiyan Wataru, Kuroki Hiroshi

    PLOS ONE   11 巻 ( 3 )   2016年3月

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    記述言語:英語  

    The repair of articular cartilage is challenging owing to the restriction in the ability of articular cartilage to repair itself. Therefore, cell supplementation therapy is possible cartilage repair method. However, few studies have verified the efficacy and safety of cell supplementation therapy. The current study assessed the effect of exercise on early the phase of cartilage repair following cell supplementation utilizing mesenchymal stromal cell (MSC) intra-articular injection. An osteochondral defect was created on the femoral grooves bilaterally of Wistar rats. Mesenchymal stromal cells that were obtained from male Wistar rats were cultured in monolayer. After 4 weeks, MSCs were injected into the right knee joint and the rats were randomized into an exercise or no-exercise intervention group. The femurs were divided as follows: C group (no exercise without MSC injection); E group (exercise without MSC injection); M group (no exercise with MSC injection); and ME group (exercise with MSC injection). At 2, 4, and 8 weeks after the injection, the femurs were sectioned and histologically graded using the Wakitani cartilage repair scoring system. At 2 weeks after the injection, the total histological scores of the M and ME groups improved significantly compared with those of the C group. Four weeks after the injection, the scores of both the M and ME groups improved significantly. Additionally, the scores in the ME group showed a significant improvement compared to those in the M group. The improvement in the scores of the E, M, and ME groups at 8 weeks were not significantly different. The findings indicate that exercise may enhance cartilage repair after an MSC intra-articular injection. This study highlights the importance of exercise following cell transplantation therapy.

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  56. Subchondral plate porosity colocalizes with the point of mechanical load during ambulation in a rat knee model of post-traumatic osteoarthritis 国際誌

    Iijima H., Aoyama T., Tajino J., Ito A., Nagai M., Yamaguchi S., Zhang X., Kiyan W., Kuroki H.

    OSTEOARTHRITIS AND CARTILAGE   24 巻 ( 2 ) 頁: 354 - 63   2016年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Osteoarthritis and Cartilage  

    Objective: This study investigated the association between spatiotemporal cartilage-subchondral bone plate alterations and mechanical load during ambulation in an experimental rat model of destabilized medial meniscus (DMM). Design: Twelve-week-old Wistar rats (n = 38) underwent DMM surgery on the right knee and sham surgery on the left knee. At 2 and 4 weeks after surgery, subchondral bone changes were evaluated via micro-computed tomography with various knee flexion angles to simulate weight-bearing during rat ambulation under a 3-dimensional motion capture apparatus. Additionally, the biomechanical properties, histology, and ultrastructure of the medial tibia and femoral condyle were evaluated. Results: Focal subchondral bone plate perforations were confirmed in the medial tibia within 2 weeks after surgery and were aggravated rapidly 2 weeks later. This subchondral plate porosity colocalized with articular cartilage lesions as confirmed by histology and scanning electron microscopy, and coincided with the likely point of contact between the posterior femoral condyle and tibial plateau during ambulation. Biomechanical properties were confirmed at the medial tibia, at which stiffness was reduced to approximately half that of the sham-operated knee at 4 weeks after surgery. Conclusions: Cartilage-subchondral bone plate alterations localized in the region of the point of mechanical load during ambulation in DMM-operated knees, at which the mechanical integrity of cartilage was impaired. These results indicate that DMM-induced increases in mechanical load play an important role in the pathogenesis of early post-traumatic osteoarthritis (OA), and it might accelerate the development of the disease via cartilage-subchondral bone plate crosstalk through increased subchondral plate perforations.

    DOI: 10.1016/j.joca.2015.09.001

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  57. Association of Varus Thrust With Pain and Stiffness and Activities of Daily Living in Patients With Medial Knee Osteoarthritis. 国際誌

    Naoto Fukutani, Hirotaka Iijima, Takahiko Fukumoto, Daisuke Uritani, Eishi Kaneda, Kazuo Ota, Tomoki Aoyama, Tadao Tsuboyama, Shuichi Matsuda

    Physical therapy   96 巻 ( 2 ) 頁: 167 - 75   2016年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Increasing evidence highlights potential associations between varus thrust and health domains associated with knee osteoarthritis (OA). OBJECTIVE: The aim of this study was to investigate the association between varus thrust and 2 subcategories-"pain and stiffness" and "activities of daily living (ADL)"-of the Japanese Knee Osteoarthritis Measure (JKOM). DESIGN: This was a cross-sectional study. METHODS: In total, 296 outpatients with knee OA visiting orthopedic clinics were enrolled. The inclusion criteria were age ≥50 years, medial knee OA and Kellgren-Lawrence (K/L) grade ≥1 in one or both knees, and the ability to walk independently. Standard posterior-anterior knee radiographs were measured for varus alignment. Participants were video recorded while walking and were evaluated for the presence or absence of varus thrust. Pain and stiffness of the knee joint and ADL were evaluated using the JKOM. Multivariate regressions (outcomes: pain and stiffness and ADL; predictor variable: varus thrust) were performed. RESULTS: Varus thrust was present in 46 (16.2%) of 284 patients. Multivariate regression analyses demonstrated that varus thrust is independently associated with pain and stiffness, adjusted for age, sex, body mass index, K/L grade, and varus alignment (β=.17, P=.005). However, the association between varus thrust and ADL was not significant (β=.11, P=.058). Based on sensitivity analyses, including participants of K/L grade 1 had little influence on this analysis. LIMITATIONS: Only 16.2% of participants had a varus thrust. Moreover, a cause-effect relationship between varus thrust and pain and stiffness remains unknown due to the cross-sectional design of this study. CONCLUSIONS: Varus thrust was associated with pain and stiffness in patients with medial knee OA. However, the association between varus thrust and ADL did not reach significance.

    DOI: 10.2522/ptj.20140441

    PubMed

  58. The Effect of Exercise on the Early Stages of Mesenchymal Stromal Cell-Induced Cartilage Repair in a Rat Osteochondral Defect Model 国際誌

    Yamaguchi Shoki, Aoyama Tomoki, Ito Akira, Nagai Momoko, Iijima Hirotaka, Tajino Junichi, Zhang Xiangkai, Kiyan Wataru, Kuroki Hiroshi

    PLOS ONE   11 巻 ( 3 ) 頁: e0151580   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1371/journal.pone.0151580

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  59. Effect of microfabricated microgroove-surface devices on the morphology of mesenchymal stem cells. 国際誌

    Xiangkai Zhang, Tomoki Aoyama, Takashi Yasuda, Makoto Oike, Akira Ito, Junichi Tajino, Momoko Nagai, Rune Fujioka, Hirotaka Iijima, Shoki Yamaguchi, Norihiro Kakinuma, Hiroshi Kuroki

    Biomedical microdevices   17 巻 ( 6 ) 頁: 116 - 116   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The surface of a material that is in contact with cells is known to affect cell morphology and function. To develop an appropriate surface for tendon engineering, we used zigzag microgroove surfaces, which are similar to the tenocyte microenvironment. The purpose of this study was to investigate the effect of microgroove surfaces with different ridge angles (RAs), ridge lengths (RLs), ridge widths (RWs), and groove widths (GWs) on human bone marrow-derived mesenchymal stem cell (MSC) shape. Dishes with microgroove surfaces were fabricated using cyclic olefin polymer by injection-compression molding. The other parameters were fixed, and effects of different RAs (180 - 30 °), RLs (5 - 500 μm), RWs (5 - 500 μm), and GWs (5 - 500 μm) were examined. Changes in the zigzag shape of the cell due to different RAs, RLs, RWs, and GWs were observed by optical microscopy and scanning electron microscopy. Cytoskeletal changes were investigated using Phalloidin immunofluorescence staining. As observed by optical microscopy, MSCs changed to a zigzag shape in response to microgroove surfaces with different ridge and groove properties. . As observed by scanning electron microscopy, the cell shape changed at turns in the microgroove surface. Phalloidin immunofluorescence staining indicated that F-actin, not only in cell filopodia but also inside the cell body, changed orientation to conform to the microgrooves. In conclusion, the use of zigzag microgroove surfaces microfabricated by injection-compression molding demonstrated the property of MSCs to alter their shapes to fit the surface.

    DOI: 10.1007/s10544-015-0016-0

    PubMed

  60. Clinical Phenotype Classifications Based on Static Varus Alignment and Varus Thrust in Japanese Patients With Medial Knee Osteoarthritis. 国際誌

    Hirotaka Iijima, Naoto Fukutani, Tomoki Aoyama, Takahiko Fukumoto, Daisuke Uritani, Eishi Kaneda, Kazuo Ota, Hiroshi Kuroki, Shuichi Matsuda

    Arthritis & rheumatology (Hoboken, N.J.)   67 巻 ( 9 ) 頁: 2354 - 62   2015年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To investigate the association between knee pain during gait and 4 clinical phenotypes based on static varus alignment and varus thrust in patients with medial knee osteoarthritis (OA). METHODS: Patients in an orthopedic clinic (n = 266) diagnosed as having knee OA (Kellgren/Lawrence [K/L] grade ≥1) were divided into 4 phenotype groups according to the presence or absence of static varus alignment and varus thrust (dynamic varus): no varus (n = 173), dynamic varus (n = 17), static varus (n = 50), and static varus + dynamic varus (n = 26). The knee range of motion, spatiotemporal gait parameters, visual analog scale scores for knee pain, and scores on the Japanese Knee Osteoarthritis Measure were used to assess clinical outcomes. Multiple logistic regression analyses identified the relationship between knee pain during gait and the 4 phenotypes, adjusted for possible risk factors, including age, sex, body mass index, K/L grade, and gait velocity. RESULTS: Multiple logistic regression analysis showed that varus thrust without varus alignment was associated with knee pain during gait (odds ratio [OR] 3.30, 95% confidence interval [95% CI] 1.08-12.4), and that varus thrust combined with varus alignment was strongly associated with knee pain during gait (OR 17.1, 95% CI 3.19-320.0). Sensitivity analyses applying alternative cutoff values for defining static varus alignment showed comparable results. CONCLUSION: Varus thrust with or without static varus alignment was associated with the occurrence of knee pain during gait. Tailored interventions based on individual malalignment phenotypes may improve clinical outcomes in patients with knee OA.

    DOI: 10.1002/art.39224

    PubMed

  61. Effects of short-term gentle treadmill walking on subchondral bone in a rat model of instability-induced osteoarthritis. 国際誌

    H Iijima, T Aoyama, A Ito, S Yamaguchi, M Nagai, J Tajino, X Zhang, H Kuroki

    Osteoarthritis and cartilage   23 巻 ( 9 ) 頁: 1563 - 74   2015年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Subchondral bone cyst (SBC) growth, caused by osteoclast activity during early knee osteoarthritis (OA) pathogenesis, should be treated to prevent further progressions of OA. In the present study, we evaluated the effects of gentle treadmill walking on subchondral bone and cartilage changes in an experimental rat model of destabilized medial meniscus (DMM). METHOD: Twelve-week-old Wistar rats underwent DMM surgery in their right knee and sham surgery in their left knee and were assigned to either the sedentary group or walking group (n = 42/group). Animals in the walking group were subjected to treadmill exercise 2 days after surgery, which included walking for 12 m/min, 30 min/day, 5 days/week for 1, 2, and 4 week(s). Subchondral bone and cartilage changes were evaluated by micro-CT analysis, histological analysis, and biomechanical analysis. RESULTS: Treadmill walking had a tendency to suppress SBC growth, which was confirmed by micro-CT (P = 0.06) and positive staining for tartrate-resistant acid phosphatase (TRAP) activity for the osteoclast number per bone surface (P = 0.09) 4 weeks after surgery. These changes coincide with the prevention of cartilage degeneration as evaluated by the Osteoarthritis Research Society International (OARSI) score (P < 0.05) and biomechanically softening (P < 0.05). Furthermore, treadmill walking could suppressed increasing osteocyte deaths (P < 0.01), which was positively correlated with the OARSI score (r = 0.77; P < 0.01). CONCLUSION: These results indicate biomechanical and biological links exist between cartilage and subchondral bone; preventive effects of treadmill walking on subchondral bone deterioration might be partly explained by the chondroprotective effects.

    DOI: 10.1016/j.joca.2015.04.015

    PubMed

  62. The effects of short-term hypoxia on human mesenchymal stem cell proliferation, viability and p16(INK4A) mRNA expression: Investigation using a simple hypoxic culture system with a deoxidizing agent

    Ito Akira, Aoyama Tomoki, Yoshizawa Makoto, Nagai Momoko, Tajino Junichi, Yamaguchi Shoki, Iijima Hirotaka, Zhang Xiangkai, Kuroki Hiroshi

      11 巻 ( 1 ) 頁: 25 - 31   2015年5月

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    記述言語:英語  

    A hypoxic environment is thought to be important for the maintenance of stemness and suppressing cell senescence, in stem cells. Therefore, a hypoxic condition is induced during cell expansion and/or induction of intended differentiation. However, the induction of these conditions requires a specially equipped hypoxia chamber and expensive gas mixtures, which are expensive and space-consuming. Owing to these restrictions, appropriate hypoxic conditions cannot be provided during cell transportation, which is increasingly required for regenerative medicine. Hence, a simple and economical culture system is required. The purpose of this study was to investigate the effects of short-term hypoxic conditions on human mesenchymal stem cell (MSC) proliferation, viability, and senescence, utilizing the CulturePal system (CulturePal-Zero and CulturePal-Five), a novel and simple hypoxic culture system with a built-in deoxidizing agent. The O₂ concentration in the CulturePal-Zero was observed to reduce to <0.1% within 1 h, and to 5% within 24 h in the CulturePal-Five system. Cell proliferation under these hypoxic conditions showed a sharp increase at 5% O₂ concentration, and no noticeable cell death was observed even at severe hypoxic conditions (<0.1% O₂) up to 72h. The p16INK4A (cell senescence marker) mRNA expression was retained under hypoxic conditions up to 72h, but it was up-regulated under normoxic conditions. Interestingly, the p16INK4A expression altered proportionately to the O₂ concentration. These results indicated that the short-term hypoxic condition, at an approximate O₂ concentration of 5%, would be suitable for promoting cell proliferation and repressing cell senescence, without aggravating the MSC viability. Therefore, the CulturePal systems may be suitable for providing an appropriate hypoxic condition in stem cell research and transportation.

    CiNii Research

  63. Alteration of cartilage surface collagen fibers differs locally after immobilization of knee joints in rats. 国際誌

    Momoko Nagai, Tomoki Aoyama, Akira Ito, Junichi Tajino, Hirotaka Iijima, Shoki Yamaguchi, Xiangkai Zhang, Hiroshi Kuroki

    Journal of anatomy   226 巻 ( 5 ) 頁: 447 - 57   2015年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The purpose of this study was to examine the ultrastructural changes of surface cartilage collagen fibers, which differ by region and the length of the experimental period in an immobilization model of rat. Male Wistar rats were randomly divided into histological or macroscopic and ultrastructural assessment groups. The left knees of all the animals were surgically immobilized by external fixation for 1, 2, 4, 8 or 16 weeks (n = 5/time point). Sagittal histological sections of the medial mid-condylar region of the knee were obtained and assessed in four specific regions (contact and peripheral regions of the femur and tibia) and two zones (superficial and deep). To semi-quantify the staining intensity of the collagen fibers in the cartilage, picrosirius red staining was used. The cartilage surface changes of all the assessed regions were investigated by scanning electron microscopy (SEM). From histological and SEM observations, the fibrillation and irregular changes of the cartilage surface were more severe in the peripheral region than in the contact region. Interestingly, at 16 weeks post-immobilization, we observed non-fibrous structures at both the contact and peripheral regions. The collagen fiber staining intensity decreased in the contact region compared with the peripheral region. In conclusion, the alteration of surface collagen fiber ultrastructure and collagen staining intensity differed by the specific cartilage regions after immobilization. These results demonstrate that the progressive degeneration of cartilage is region specific, and depends on the length of the immobilization period.

    DOI: 10.1111/joa.12290

    PubMed

  64. Culture temperature affects redifferentiation and cartilaginous extracellular matrix formation in dedifferentiated human chondrocytes. 国際誌

    Akira Ito, Tomoki Aoyama, Hirotaka Iijima, Junichi Tajino, Momoko Nagai, Shoki Yamaguchi, Xiangkai Zhang, Hiroshi Kuroki

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society   33 巻 ( 5 ) 頁: 633 - 9   2015年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    To date, there have been few studies on how temperature affects the phenotype and metabolism of human chondrocytes. Thus, the purpose of this study was to elucidate the effects of culture temperature on chondrocyte redifferentiation and extracellular matrix (ECM) formation using dedifferentiated mature human chondrocytes in vitro. Dedifferentiated chondrocytes were cultured in a pellet culture system for up to 21 days. The pellets were randomly divided into three groups with different culture temperature (32, 37, and 41°C). Chondrocyte redifferentiation and ECM formation were evaluated by wet weight, messenger ribonucleic acid (mRNA), histological, and biochemical analyses. The results showed that the wet weight and the mRNA expressions of collagen type II A1 and cartilage oligomeric matrix protein at 37°C were higher than the corresponding values at 32°C. The histological and biochemical analyses revealed that the syntheses of type II collagen and proteoglycan were promoted at 37°C compared to those at 32°C, whereas they were considerably inhibited at 41°C. In conclusion, the results obtained herein indicated that temperature affects chondrocyte redifferentiation and ECM formation, and modulation of temperature might thus represent an advantageous means to regulate the phenotype and biosynthetic activity of chondrocytes.

    DOI: 10.1002/jor.22808

    PubMed

  65. The effects of short-term hypoxia on human mesenchymal stem cell proliferation, viability and p16<sup>INK4A</sup> mRNA expression: Investigation using a simple hypoxic culture system with a deoxidizing agent

    Ito A., Aoyama T., Yoshizawa M., Nagai M., Tajino J., Yamaguchi S., Iijima H., Zhang X., Kuroki H.

    Journal of Stem Cells and Regenerative Medicine   11 巻 ( 1 ) 頁: P25 - P31   2015年

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    記述言語:日本語   出版者・発行元:Journal of Stem Cells and Regenerative Medicine  

    A hypoxic environment is thought to be important for the maintenance of stemness and suppressing cell senescence, in stem cells. Therefore, a hypoxic condition is induced during cell expansion and/or induction of intended differentiation. However, the induction of these conditions requires a specially equipped hypoxia chamber and expensive gas mixtures, which are expensive and space-consuming. Owing to these restrictions, appropriate hypoxic conditions cannot be provided during cell transportation, which is increasingly required for regenerative medicine. Hence, a simple and economical culture system is required. The purpose of this study was to investigate the effects of short-term hypoxic conditions on human mesenchymal stem cell (MSC) proliferation, viability, and senescence, utilizing the CulturePal system (CulturePal-Zero and CulturePal-Five), a novel and simple hypoxic culture system with a built-in deoxidizing agent. The O2 concentration in the CulturePal-Zero was observed to reduce to <0.1% within 1 h, and to 5% within 24h in the CulturePal-Five system. Cell proliferation under these hypoxic conditions showed a sharp increase at 5% O2 concentration, and no noticeable cell death was observed even at severe hypoxic conditions (<0.1% O2) up to 72h. The p16INK4A (cell senescence marker) mRNA expression was retained under hypoxic conditions up to 72h, but it was up-regulated under normoxic conditions. Interestingly, the p16INK4A expression altered proportionately to the O2 concentration. These results indicated that the short-term hypoxic condition, at an approximate O2 concentration of 5%, would be suitable for promoting cell proliferation and repressing cell senescence, without aggravating the MSC viability. Therefore, the CulturePal systems may be suitable for providing an appropriate hypoxic condition in stem cell research and transportation.

    Scopus

  66. Culture temperature affects human chondrocyte messenger RNA expression in monolayer and pellet culture systems. 国際誌

    Akira Ito, Momoko Nagai, Junichi Tajino, Shoki Yamaguchi, Hirotaka Iijima, Xiangkai Zhang, Tomoki Aoyama, Hiroshi Kuroki

    PloS one   10 巻 ( 5 ) 頁: e0128082   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Cell-based therapy has been explored for articular cartilage regeneration. Autologous chondrocyte implantation is a promising cell-based technique for repairing articular cartilage defects. However, there are several issues such as chondrocyte de-differentiation. While numerous studies have been designed to overcome some of these issues, only a few have focused on the thermal environment that can affect chondrocyte metabolism and phenotype. In this study, the effects of different culture temperatures on human chondrocyte metabolism- and phenotype-related gene expression were investigated in 2D and 3D environments. Human chondrocytes were cultured in a monolayer or in a pellet culture system at three different culture temperatures (32°C, 37°C, and 41°C) for 3 days. The results showed that the total RNA level, normalized to the threshold cycle value of internal reference genes, was higher at lower temperatures in both culture systems. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and citrate synthase (CS), which are involved in glycolysis and the citric acid cycle, respectively, were expressed at similar levels at 32°C and 37°C in pellet cultures, but the levels were significantly lower at 41°C. Expression of the chondrogenic markers, collagen type IIA1 (COL2A1) and aggrecan (ACAN), was higher at 37°C than at 32°C and 41°C in both culture systems. However, this phenomenon did not coincide with SRY (sex-determining region Y)-box 9 (SOX9), which is a fundamental transcription factor for chondrogenesis, indicating that a SOX9-independent pathway might be involved in this phenomenon. In conclusion, the expression of chondrocyte metabolism-related genes at 32°C was maintained or enhanced compared to that at 37°C. However, chondrogenesis-related genes were further induced at 37°C in both culture systems. Therefore, manipulating the culture temperature may be an advantageous approach for regulating human chondrocyte metabolic activity and chondrogenesis.

    DOI: 10.1371/journal.pone.0128082

    PubMed

  67. The effects of short-term hypoxia on human mesenchymal stem cell proliferation, viability and p16(INK4A) mRNA expression: Investigation using a simple hypoxic culture system with a deoxidizing agent. 国際誌

    Akira Ito, Tomoki Aoyama, Makoto Yoshizawa, Momoko Nagai, Junichi Tajino, Shoki Yamaguchi, Hirotaka Iijima, Xiangkai Zhang, Hiroshi Kuroki

    Journal of stem cells & regenerative medicine   11 巻 ( 1 ) 頁: 25 - 31   2015年

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A hypoxic environment is thought to be important for the maintenance of stemness and suppressing cell senescence, in stem cells. Therefore, a hypoxic condition is induced during cell expansion and/or induction of intended differentiation. However, the induction of these conditions requires a specially equipped hypoxia chamber and expensive gas mixtures, which are expensive and space-consuming. Owing to these restrictions, appropriate hypoxic conditions cannot be provided during cell transportation, which is increasingly required for regenerative medicine. Hence, a simple and economical culture system is required. The purpose of this study was to investigate the effects of short-term hypoxic conditions on human mesenchymal stem cell (MSC) proliferation, viability, and senescence, utilizing the CulturePal system (CulturePal-Zero and CulturePal-Five), a novel and simple hypoxic culture system with a built-in deoxidizing agent. The O2 concentration in the CulturePal-Zero was observed to reduce to <0.1% within 1 h, and to 5% within 24h in the CulturePal-Five system. Cell proliferation under these hypoxic conditions showed a sharp increase at 5% O2 concentration, and no noticeable cell death was observed even at severe hypoxic conditions (<0.1% O2) up to 72h. The p16(INK4A) (cell senescence marker) mRNA expression was retained under hypoxic conditions up to 72h, but it was up-regulated under normoxic conditions. Interestingly, the p16(INK4A) expression altered proportionately to the O2 concentration. These results indicated that the short-term hypoxic condition, at an approximate O2 concentration of 5%, would be suitable for promoting cell proliferation and repressing cell senescence, without aggravating the MSC viability. Therefore, the CulturePal systems may be suitable for providing an appropriate hypoxic condition in stem cell research and transportation.

    PubMed

  68. Intermittent application of hypergravity by centrifugation attenuates disruption of rat gait induced by 2 weeks of simulated microgravity. 国際誌

    Junichi Tajino, Akira Ito, Momoko Nagai, Xiangkai Zhang, Shoki Yamaguchi, Hirotaka Iijima, Tomoki Aoyama, Hiroshi Kuroki

    Behavioural brain research   287 巻   頁: 276 - 84   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The effects of intermittent hypergravity on gait alterations and hindlimb muscle atrophy in rats induced by 2 weeks of simulated microgravity were investigated. Rats were submitted to hindlimb unloading for 2 weeks (unloading period), followed by 2 weeks of reloading (recovery period). During the unloading period, animals were subjected to the following treatments: (1) free in cages (Control); (2) continuous unloading (UL); (3) released from unloading for 1 hour per day (UL+1G); (4) hypergravity for 1h per day using a centrifuge for small animals (UL+2G). The relative weights of muscles to the whole body weight and kinematics properties of hindlimbs during gait were evaluated. UL rats walked with their hindlimbs overextended, and the oscillation of their limb motion had become narrowed and forward-shifted after the unloading period, and this persisted for at least 2 weeks after the termination of unloading. However, these locomotor alterations were attenuated in rats subjected to UL+2G centrifugation despite minor systematic changes in muscle recovery. These findings indicate hypergravity application could counteract the adverse effects of simulated or actual microgravity environments.

    DOI: 10.1016/j.bbr.2015.03.030

    PubMed

  69. Discordance in recovery between altered locomotion and muscle atrophy induced by simulated microgravity in rats. 国際誌

    Junichi Tajino, Akira Ito, Momoko Nagai, Xiangkai Zhang, Shoki Yamaguchi, Hirotaka Iijima, Tomoki Aoyama, Hiroshi Kuroki

    Journal of motor behavior   47 巻 ( 5 ) 頁: 397 - 406   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Exposure to a microgravity environment leads to adverse effects in motion and musculoskeletal properties. However, few studies have investigated the recovery of altered locomotion and muscle atrophy simultaneously. The authors investigated altered locomotion in rats submitted to simulated microgravity by hindlimb unloading for 2 weeks. Motion deficits were characterized by hyperextension of the knees and ankle joints and forward-shifted limb motion. Furthermore, these locomotor deficits did not revert to their original form after a 2-week recovery period, although muscle atrophy in the hindlimbs had recovered, implying discordance in recovery between altered locomotion and muscle atrophy, and that other factors such as neural drives might control behavioral adaptations to microgravity.

    DOI: 10.1080/00222895.2014.1003779

    PubMed

  70. Regional Comparisons of Porcine Menisci 国際誌

    Zhang Xiangkai, Aoyama Tomoki, Ito Akira, Tajino Junichi, Nagai Momoko, Yamaguchi Shoki, Iijima Hirotaka, Kuroki Hiroshi

    JOURNAL OF ORTHOPAEDIC RESEARCH   32 巻 ( 12 ) 頁: 1602 - 11   2014年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Orthopaedic Research  

    The purpose of this study was to analyze histologic, biochemical, and biomechanical differences between zonal, regional, and anatomic locations of porcine menisci. We evaluated six menisci removed from pigs. Medial and lateral menisci were divided into three regions: anterior, middle, and posterior. In each portion, the central zone (CZ) and peripheral zone (PZ) were examined histologically (hematoxylin &eosin, safranin O/Fast green, and picrosiriusred staining), using scanning electron microscopy, biochemically (hydroxyproline assay for collagen content and dimethylmethylene blue assay for glycosaminoglycan [GAG] content), and biomechanically (compression testing). Collagen content in the CZ was lower than that in the PZ. GAG content in the CZ was higher than that in the PZ. GAG content in the PZ of the posterior portion was significantly higher than that in the anterior and middle portions. Compression strength in the CZ was higher than that in the PZ. The differences in cellular phenotype, vascular penetration, and ECM not only between CZ and PZ but also among the anterior, middle, and posterior portions were clarified in the immature porcine meniscus. This result helps further our understanding of the biological characteristic of the meniscus.

    DOI: 10.1002/jor.22687

    Web of Science

    Scopus

    PubMed

  71. Contributions of biarticular myogenic components to the limitation of the range of motion after immobilization of rat knee joint. 国際誌

    Momoko Nagai, Tomoki Aoyama, Akira Ito, Hirotaka Iijima, Shoki Yamaguchi, Junichi Tajino, Xiangkai Zhang, Haruhiko Akiyama, Hiroshi Kuroki

    BMC musculoskeletal disorders   15 巻   頁: 224 - 224   2014年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Muscle atrophy caused by immobilization in the shortened position is characterized by a decrease in the size or cross-sectional area (CSA) of myofibers and decreased muscle length. Few studies have addressed the relationship between limitation of the range of motion (ROM) and the changes in CSA specifically in biarticular muscles after atrophy because of immobilization. We aimed to determine the contribution of 2 distinct muscle groups, the biarticular muscles of the post thigh (PT) and those of the post leg (PL), to the limitation of ROM as well as changes in the myofiber CSAs after joint immobilization surgery. METHODS: Male Wistar rats (n = 40) were randomly divided into experimental and control groups. In the experimental group, the left knee was surgically immobilized by external fixation for 1, 2, 4, 8, or 16 weeks (n = 5 each) and sham surgery was performed on the right knee. The rats in the control groups (n = 3 per time point) did not undergo surgery. After the indicated immobilization periods, myotomy of the PT or PL biarticular muscles was performed and the ROM was measured. The hamstrings and gastrocnemius muscles from the animals operated for 1 or 16 weeks were subjected to morphological analysis. RESULTS: In immobilized knees, the relative contribution of the PT biarticular myogenic components to the total restriction reached 80% throughout the first 4 weeks and decreased thereafter. The relative contribution of the PL biarticular myogenic components remained <20% throughout the immobilization period. The ratio of the myofiber CSA of the immobilized to that of the sham-operated knees was significantly lower at 16 weeks after surgery than at 1 week after surgery only in the hamstrings. CONCLUSIONS: The relative contribution of the PT and PL components to myogenic contracture did not significantly change during the experimental period. However, the ratio of hamstrings CSAs to the sham side was larger than the ratio of medial gastrocnemius CSAs to the sham side after complete atrophy because of immobilization.

    DOI: 10.1186/1471-2474-15-224

    PubMed

  72. Destabilization of the medial meniscus leads to subchondral bone defects and site-specific cartilage degeneration in an experimental rat model. 国際誌

    H Iijima, T Aoyama, A Ito, J Tajino, M Nagai, X Zhang, S Yamaguchi, H Akiyama, H Kuroki

    Osteoarthritis and cartilage   22 巻 ( 7 ) 頁: 1036 - 43   2014年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: This study aimed to investigate subchondral bone changes using micro-computed tomography (micro-CT) and regional differences in articular cartilage degeneration, focusing on changes of cartilage covered by menisci, in the early phase using a destabilization of the medial meniscus (DMM) model. METHOD: The DMM model was created as an experimental rat osteoarthritis (OA) model (12 weeks old; n = 24). At 1, 2, and 4 weeks after surgery, the rats were sacrificed, and knee joints were scanned using a Micro-CT system. Histological sections of the medial tibial plateau, which was divided into inner, middle, and outer regions, were prepared and scored using the modified OARSI scoring system. The cartilage thickness was also calculated, and matrix metalloproteinase 13 (MMP13), Col2-3/4c, and vascular endothelial growth factor (VEGF) expression was assessed immunohistochemically. RESULTS: Subchondral bone defects were observed in the middle region, in which the cartilage thickness decreased over time after surgery, and these defects were filled with MMP13- and VEGF-expressing fibrous tissue. The OARSI score increased over time in the middle region, and the score was significantly higher in the middle region than in the inner and outer regions at 1, 2, and 4 weeks after surgery. Col2-3/4c and MMP13 expression was observed primarily in the meniscus-covered outer region, in which the cartilage thickness increased over time. CONCLUSION: Loss of meniscal function caused cartilage degeneration and subchondral bone defects in the early phase site-specifically in the middle region. Furthermore, our results might indicate cartilage covered by menisci is easily degraded resulting in osmotic swelling of the cartilage in early OA.

    DOI: 10.1016/j.joca.2014.05.009

    PubMed

  73. Evaluation of reference genes for human chondrocytes cultured in several different thermal environments. 国際誌

    Akira Ito, Tomoki Aoyama, Junichi Tajino, Momoko Nagai, Shoki Yamaguchi, Hirotaka Iijima, Xiangkai Zhang, Haruhiko Akiyama, Hiroshi Kuroki

    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group   30 巻 ( 3 ) 頁: 210 - 6   2014年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: The purpose of this study was to identify reference genes showing stable expression in chondrocytes cultured under several different thermal environments and in different culture systems. MATERIALS AND METHODS: Human articular chondrocytes were cultured by monolayer or pellet culture system at 32 °C, 37 °C, and 41 °C for 3 days. Thereafter, the total RNA was extracted, and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was performed. The qRT-PCR data was analysed using three different algorithms (geNorm, NormFinder, and BestKeeper) to identify reference genes exhibiting stable expression from among the seven candidate reference genes (B2M, ACTB, GAPDH, HSPCB, RPL13a, YWHAZ, and 18S). RESULTS: The candidate reference genes, except for HSPCB and YWHAZ, showed systematic variations in expression. In the monolayer culture, RPL13a was the most stable gene identified using NormFinder and BestKeeper; on using geNorm, ACTB and GAPDH showed the highest expression stability. In the pellet culture, ACTB was the most stable gene identified using NormFinder and BestKeeper, whereas GAPDH and RPL13a were the most stable reference genes as determined using geNorm. In the combined group, B2M and GAPDH were the most stable genes identified using geNorm, whereas RPL13a and YWHAZ were the most stable as per NormFinder and BestKeeper, respectively. The best combination of two candidate reference genes among all the groups determined using NormFinder was RPL13a and YWHAZ. CONCLUSION: The combination of RPL13a and YWHAZ might be suitable as reference genes for human chondrocytes cultured at 32 °C, 37 °C, and 41 °C in monolayer, pellet, or combined cultures.

    DOI: 10.3109/02656736.2014.906048

    PubMed

  74. Immature articular cartilage and subchondral bone covered by menisci are potentially susceptive to mechanical load. 国際誌

    Hirotaka Iijima, Tomoki Aoyama, Akira Ito, Junichi Tajino, Momoko Nagai, Xiangkai Zhang, Shoki Yamaguchi, Haruhiko Akiyama, Hiroshi Kuroki

    BMC musculoskeletal disorders   15 巻   頁: 101 - 101   2014年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The differences of mechanical and histological properties between cartilage covered by menisci and uncovered by menisci may contribute to the osteoarthritis after meniscectomy and these differences are not fully understood. The purpose of this study is to investigate potential differences in the mechanical and histological properties, and in particular the collagen architecture, of the superficial cartilage layer and subchondral bone between regions covered and uncovered by menisci using immature knee. METHODS: Osteochondral plugs were obtained from porcine tibial cartilage that was either covered or uncovered by menisci. Investigation of the thickness, mechanical properties, histology, and water content of the cartilage as well as micro-computed tomography analysis of the subchondral bone was performed to compare these regions. Collagen architecture was also assessed by using scanning electron microscopy. RESULTS: Compared to the cartilage uncovered by menisci, that covered by menisci was thinner and showed a higher deformity to compression loading and higher water content. In the superficial layer of cartilage in the uncovered regions, collagen fibers showed high density, whereas they showed low density in covered regions. Furthermore, subchondral bone architecture varied between the 2 regions, and showed low bone density in covered regions. CONCLUSIONS: Cartilage covered by menisci differed from that uncovered in both its mechanical and histological properties, especially with regards to the density of the superficial collagen layer. These regional differences may be related to local mechanical environment in normal condition and indicate that cartilage covered by menisci is tightly guarded by menisci from extreme mechanical loading. Our results indicate that immature cartilage degeneration and subchondral microfracture may occur easily to extreme direct mechanical loading in covered region after meniscectomy.

    DOI: 10.1186/1471-2474-15-101

    PubMed

  75. Optimum temperature for extracellular matrix production by articular chondrocytes. 国際誌

    Akira Ito, Tomoki Aoyama, Hirotaka Iijima, Momoko Nagai, Shoki Yamaguchi, Junichi Tajino, Xiangkai Zhang, Haruhiko Akiyama, Hiroshi Kuroki

    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group   30 巻 ( 2 ) 頁: 96 - 101   2014年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: The purpose of this study was to investigate the influence of temperature on the ability of the chondrocytes to produce extracellular matrix (ECM). MATERIALS AND METHODS: Articular chondrocytes were isolated from porcine knee joints. The chondrocytes were cultured at three different temperatures: 32 °C, 37 °C, and 41 °C. The ability to produce ECM was assessed by gene expression analysis, histological, and biochemical evaluation in a pellet culture system. RESULTS: Wet weight of the pellets generated after 21 days, was significantly heavier when cultured at lower temperatures. Picrosirius red staining, employed to evaluate collagen production, was higher at lower temperatures, and safranin-O staining, used to evaluate sulphated glycosaminoglycan (GAG), was lower at 32 °C than at 37 °C and 41 °C. Collagen type IIA1 mRNA expression was markedly up-regulated at 41 °C. However, picrosirius red staining was inhibited at 41 °C. GAG and DNA content were measured by 1,9-dimethylmethylene blue (DMMB) assay and PicoGreen® assay, respectively. The GAG content per pellet was significantly low at 41 °C compared to that at 32 °C and 37 °C. The DNA content per pellet was larger at lower temperatures. The GAG content normalised with the DNA content per pellet was significantly lower at 32 °C compared to that at 37 °C and 41 °C. CONCLUSION: Our results suggest that a culture temperature of approximately 41 °C inhibits ECM production by decreasing DNA content and perhaps by collagen misfolding. Taken together, the optimum temperature for ECM production in articular chondrocytes may be between 32 °C and 37 °C.

    DOI: 10.3109/02656736.2014.880857

    PubMed

  76. Effects of knee orthoses on walking capacity and biomechanics in patients with knee osteoarthritis: A critical review

    Hirotaka Iijima, Takuya Isho, Tomoki Aoyama

    OA Musculosk Med   2 巻 ( 13 )   2014年

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    担当区分:筆頭著者  

  77. Effects of the thermal environment on articular chondrocyte metabolism: a fundamental study to facilitate establishment of an effective thermotherapy for osteoarthritis.

    Akira Ito, Tomoki Aoyama, Junichi Tajino, Momoko Nagai, Shoki Yamaguchi, Hirotaka Iijima, Xiangkai Zhang, Haruhiko Akiyama, Hiroshi Kuroki

    Journal of the Japanese Physical Therapy Association = Rigaku ryoho   17 巻 ( 1 ) 頁: 14 - 21   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: To facilitate establishment of an effective thermotherapy for osteoarthritis (OA), we investigated the effects of the thermal environment on articular chondrocyte metabolism in vitro. METHODS: Chondrocytes were isolated from porcine knee joints, and cultured at 32°C, 37°C and 41°C. Cell proliferation and viability were assessed at Days 2, 4 and 8. In addition, TdT-mediated dUTP nick end labeling (TUNEL) assay was performed at Day 3 to determine the proportion of apoptotic chondrocytes. Analysis of genes specific for factors related to the cartilage extracellular matrix (ECM), cartilage destruction, and cartilage protection was performed at Day 2. Furthermore, evaluation of heat stress tolerance, and heat shock protein 70 (HSP70) mRNA expression and protein synthesis was performed at Day 2 and 3, respectively. RESULTS: Cell proliferation was more at 37°C than at 32°C and 41°C. Cell viability and the number of TUNEL-positive cells were not affected until Day 8 and 3, respectively. The expression of the ECM-related genes was up-regulated at higher temperature. The expression of MMP13, a type II collagen destructive enzyme, and that of TIMP1 and TIMP2, which are MMP inhibitors, were up-regulated at higher temperatures. Finally, the chondrocytes cultured at 41°C may acquire heat stress tolerance, in part, due to the up-regulation of HSP70, and may inhibit apoptosis induced by various stresses, which is observed in OA. CONCLUSIONS: The thermal environment affects articular chondrocyte metabolism, and a heat stimulus of approximately 41°C could enhance chondrocyte anabolism and induce heat stress tolerance.

    DOI: 10.1298/jjpta.Vol17_003

    PubMed

  78. 半月板を介在して荷重を担う軟骨の組織学的,力学的特性 ‐ブタ膝関節を用いた実験研究‐ 査読有り

    飯島弘貴, 青山朋樹, 伊藤明良, 太治野純一, 長井桃子, 張項凱, 山口将希, 秋山治彦, 黒木裕士

    理学療法学   40 巻 ( 5 ) 頁: 355 - 363   2013年8月

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    担当区分:筆頭著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(公社)日本理学療法士協会  

    【目的】ブタ脛骨軟骨における半月板に被覆された軟骨(被覆部軟骨)は被覆されていない軟骨(非被覆部軟骨)と比較して力学的特性や表層コラーゲン線維を中心とした組織学的所見が異なるのかを検証する。【方法】豚膝関節の内外側関節面における被覆部軟骨、非被覆部軟骨から骨軟骨プラグを採取した。各領域から得たプラグに対して力学的特性の評価としてインデンテーション試験を、組織学的評価としてサフラニンO染色を、コラーゲン線維構造の評価として走査型電子顕微鏡による観察を行った。【結果】被覆部軟骨は圧縮負荷に対する変形量が非被覆部軟骨よりも大きかった。組織学的に被覆部軟骨のサフラニンO染色性は低く、表層コラーゲン線維の密度が低かった。【結論】日常的に半月板を介在して荷重を受けていた被覆部軟骨は軟骨基質成分に乏しく、半月板損傷、半月板切除後に被覆部軟骨が直接荷重を強いられると局所的に大きな変形を生じる可能性がある。(著者抄録)

    J-GLOBAL

    その他リンク: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J01747&link_issn=&doc_id=20130827430001&doc_link_id=%2Fcb3physi%2F2013%2F004005%2F002%2F0355-0363%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcb3physi%2F2013%2F004005%2F002%2F0355-0363%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  79. Effects of exercise level on biomarkers in a rat knee model of osteoarthritis. 国際誌

    Shoki Yamaguchi, Tomoki Aoyama, Akira Ito, Momoko Nagai, Hirotaka Iijima, Xiangkai Zhang, Junichi Tajino, Hiroshi Kuroki

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society   31 巻 ( 7 ) 頁: 1026 - 31   2013年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The aim of this study was to elucidate whether the levels of serum biomarkers reflect the progression of osteoarthritis (OA) induced by different levels of exercise. Thirty-five Wistar rats subjected to anterior cruciate ligament transaction (ACLT) were divided into three groups: Control, moderate running, and intense running. Twelve rats (moderate running without ACLT) were allocated as a naive group. Running was performed on a motorized treadmill, at a speed of 18 m/min for 30 min/day (moderate and naive) or 60 min/day (intense) for 3 days per week. After 2 or 4 weeks, OA histopathology in the knees was evaluated using the Osteoarthritis Research Society International (OARSI) score, and the serum levels of cleaved collagen type II (C2C) and procollagen II C-propeptide (CPII) were analyzed. The OARSI score deteriorated in the intense running group after 2 weeks and the serum C2C/CPII ratio suggested the development of OA. At 4 weeks, the C2C/CPII ratio suggested there would be deterioration in the OARSI score but the score did not differ significantly between the moderate and intense running groups. C2C/CPII ratio had 13-25% correlation with the OARSI histological score. Thus, in rat experimental OA, the OARSI score could be partially predicted by the C2C/CPII ratio as a serum biomarker of OA.

    DOI: 10.1002/jor.22332

    PubMed

  80. 半月板を介在して荷重を担う軟骨の組織学的,力学的特性

    飯島 弘貴, 青山 朋樹, 伊藤 明良, 太治野 純一, 長井 桃子, 張 項凱, 山口 将希, 秋山 治彦, 黒木 裕士

    理学療法学   40 巻 ( 5 ) 頁: 355 - 363   2013年

     詳細を見る

    記述言語:日本語   出版者・発行元:日本理学療法士学会  

    【目的】ブタ脛骨軟骨における半月板に被覆された軟骨(被覆部軟骨)は被覆されていない軟骨(非被覆部軟骨)と比較して力学的特性や表層コラーゲン線維を中心とした組織学的所見が異なるのかを検証する。【方法】豚膝関節の内外側関節面における被覆部軟骨,非被覆部軟骨から骨軟骨プラグを採取した。各領域から得たプラグに対して力学的特性の評価としてインデンテーション試験を,組織学的評価としてサフラニンO染色を,コラーゲン線維構造の評価として走査型電子顕微鏡による観察を行った。【結果】被覆部軟骨は圧縮負荷に対する変形量が非被覆部軟骨よりも大きかった。組織学的に被覆部軟骨のサフラニンO染色性は低く,表層コラーゲン線維の密度が低かった。【結論】日常的に半月板を介在して荷重を受けていた被覆部軟骨は軟骨基質成分に乏しく,半月板損傷,半月板切除後に被覆部軟骨が直接荷重を強いられると局所的に大きな変形を生じる可能性がある。

    DOI: 10.15063/rigaku.kj00008826560

    CiNii Research

  81. ラット足関節軟骨の加齢と運動の影響 査読有り

    村田 健児, 金村 尚彦, 羽田 侑里子, 飯島 弘貴, 高柳 清美, 森山 英樹

    理学療法-臨床・研究・教育   18 巻   頁: 61 - 66   2011年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  82. 運動器障害に対する牽引療法の効果 査読有り

    森山 英樹, 飯島 弘貴, 金村 尚彦, 羽田 侑里子, 村田 健児, 今北 英高, 高柳 清美, 伊藤 俊一, 五味 敏昭, 飛松 好子

    運動療法と物理療法   20 巻 ( 4 ) 頁: 369 - 378   2009年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  83. 運動器障害に対する温熱療法の効果 査読有り

    森山 英樹, 飯島 弘貴, 金村 尚彦, 村田 健児, 羽田 侑里子, 西原 賢, 小澤 淳也, 高柳 清美, 五味 敏昭, 飛松 好子

    運動療法と物理療法   20 巻 ( 3 ) 頁: 260 - 268   2009年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

▼全件表示

書籍等出版物 1

  1. サプリメントの機能性:運動器・スポーツ

    青山朋樹, 飯島弘貴, 松田秀一( 担当: 分担執筆 ,  範囲: アンチエイジング医学の基礎と臨床. pp281–283)

    メジカルビュー社  2015年 

MISC 5

  1. 変形性膝関節症におけるメカニカルストレス研究と間葉系幹細胞治療後の再生リハビリテーション

    飯島 弘貴  

    日本基礎理学療法学雑誌22 巻 ( 1 ) 頁: 1 - 8   2019年12月

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    記述言語:日本語   出版者・発行元:(一社)日本基礎理学療法学会  

    変形性膝関節症(膝OA)軟骨におけるメカニカルストレス研究について概説し、エクササイズによる強度依存的な関節軟骨保護・破壊作用やその分子メカニズムについて述べた。次いで、間葉系幹細胞を用いた膝OA軟骨再生治療におけるリハビリテーションの可能性について述べた。最後に、膝OAの再生リハビリテーション確立に向けた新しい運動機能評価システムを紹介した。

    その他リンク: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J05805&link_issn=&doc_id=20191227260001&doc_link_id=%2Fch1thrpy%2F2019%2F002201%2F001%2F0001-0008%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fch1thrpy%2F2019%2F002201%2F001%2F0001-0008%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  2. 【運動ってなんだ?"Exercise is Medicine"を支えるサイエンスを拓く】変形性膝関節症軟骨におけるメカニカルストレス研究 運動の強度依存的な軟骨保護・破壊作用とその分子メカニズム探求の挑戦 招待有り

    飯島 弘貴  

    実験医学37 巻 ( 8 ) 頁: 1240 - 1245   2019年5月

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    担当区分:筆頭著者   記述言語:日本語  

  3. 内側型変形性膝関節症患者における膝蓋大腿関節症合併が与える臨床的影響 招待有り

    飯島 弘貴  

    整形外科68 巻 ( 12 ) 頁: 1317 - 1319   2017年11月

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    担当区分:筆頭著者  

  4. 【変形性膝関節症の診断と治療】保存的治療 理学療法 装具療法 変形性膝関節症に対する膝装具療法 膝関節痛・歩行バイオメカニクス・歩行能力に与える効果に関する臨床介入研究 招待有り

    飯島 弘貴, 井所 拓哉, 青山 朋樹, 松田 秀一  

    別冊整形外科67 巻   頁: 115 - 120   2015年4月

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    担当区分:筆頭著者  

  5. 変形性関節症に対する効果的なユビキタス治療法の開発 招待有り

    黒木裕士, 青山朋樹, 長井桃子, 山口将希, 飯島弘貴, 伊藤明良  

    大阪ガスグループ福祉財団調査・研究報告集27 巻   2014年

講演・口頭発表等 124

  1. laser-TUGシステムを用いた頸髄症患者の歩行特性の抽出

    小山 恭史, 藤田 浩二, 野呂瀬 美生, 佐々木 亨, 鏑木 秀俊, 二村 昭元, 飯島 弘貴, 高橋 正樹, 大川 淳

    日本整形外科学会雑誌  2021年8月  (公社)日本整形外科学会

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    開催年月日: 2021年8月

    記述言語:日本語  

  2. 変形性膝関節症患者における痛みの破局的思考は階段昇降動作を困難にする

    鈴木祐介, 飯島弘貴, 飯島弘貴, 青山朋樹

    Japanese Journal of Rehabilitation Medicine  2020年  (公社)日本リハビリテーション医学会

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    開催年月日: 2020年

    記述言語:日本語  

  3. Laser-TUGシステムを用いた橈骨遠位端骨折患者の歩行状態の評価 転倒とドミノ骨折の予防を目指して

    藤田 浩二, 飯島 弘貴, 奥村 篤史, 八百 陽介, 鏑木 秀俊, 二村 昭元, 加藤 龍一, 大川 淳, 高橋 正樹

    日本手外科学会雑誌  2019年4月  (一社)日本手外科学会

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    開催年月日: 2019年4月

    記述言語:日本語  

  4. Laser Range Sensorを用いた大腿骨近位部骨折患者のTUG回転方向における時空間的パラメータの比較

    丸毛達也, 武田尊徳, 白滝智洋, 安原康平, 道下将矢, 吉野晃平, 飯島弘貴, 高橋正樹

    日本理学療法学術大会(Web)  2019年  (公社)日本理学療法士協会

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    開催年月日: 2019年

    記述言語:日本語  

  5. 変形性膝関節症におけるメカニカルストレス研究と間葉系幹細胞治療後の再生リハビリテーション

    飯島弘貴, 飯島弘貴, 飯島弘貴

    日本基礎理学療法学雑誌(Web)  2019年 

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    開催年月日: 2019年

  6. 変形性膝関節症における立ち上がり動作の運動学的・運動力学的・筋電図的変化:システマティックレビュー

    園尾萌香, 園尾萌香, 飯島弘貴, 飯島弘貴, 金村尚彦

    日本理学療法学術大会(Web)  2019年  (公社)日本理学療法士協会

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    開催年月日: 2019年

    記述言語:日本語  

  7. 変形性膝関節症における再生リハビリテーション確立に向けた分野横断型研究

    飯島弘貴, 飯島弘貴, 飯島弘貴

    日本理学療法学術大会(Web)  2019年  (公社)日本理学療法士協会

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    開催年月日: 2019年

    記述言語:日本語  

  8. 橈骨遠位端骨折患者の歩行状態の評価転倒とドミノ骨折の予防を目指して

    藤田浩二, 二村昭元, 飯島弘貴, 江口僚, 加藤龍一, 大川淳, 高橋正樹

    日本骨粗鬆症学会雑誌  2019年  (一社)日本骨粗鬆症学会

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    開催年月日: 2019年

    記述言語:日本語  

  9. 膝半月不安定化による膝蓋大腿関節軟骨損傷と歩行キネマティクスの関係

    中畑晶博, 飯島弘貴, 飯島弘貴, 伊藤明良, 王天舒, 中原峻, 張ジュエ, 久保奈央子, 河合秀紀, 青山朋樹, 黒木裕士

    日本理学療法学術大会(Web)  2019年  (公社)日本理学療法士協会

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    開催年月日: 2019年

    記述言語:日本語  

  10. 早期変形性膝関節症患者の身体機能・疼痛に対する経皮的末梢神経電気刺激(TENS)の効果 ランダム化比較試験による効果検証

    下浦 佳南子, 飯島 弘貴, 鈴木 祐介, 梶原 由布, Zeidan Hala, 辰巳 昌嵩, 中井 謙吾, 西田 裕一, 備藤 翼, 吉見 そよ香, 青山 朋樹

    日本物理療法学会学術大会抄録集  2018年10月  (一社)日本物理療法学会

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    開催年月日: 2018年10月

    記述言語:日本語  

  11. Laser Range Sensorによる変形性膝関節症の方向転換動作解析と股関節外転筋の特異的貢献

    飯島弘貴, 飯島弘貴, 飯島弘貴, 青山朋樹, 高橋正樹

    Japanese Journal of Rehabilitation Medicine  2018年  (公社)日本リハビリテーション医学会

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    開催年月日: 2018年

    記述言語:日本語  

  12. レーザーレンジセンサを用いた変形性膝関節症患者の歩行パラメータ解析-膝関節痛が機能的移動能力に与える影響-

    飯島弘貴, 飯島弘貴, 飯島弘貴, 萬礼応, 江口僚, 青山朋樹, 高橋正樹

    Dynamics & Design Conference (CD-ROM)  2018年 

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    開催年月日: 2018年

  13. 変形性膝関節症を有する高齢者を対象とした,膝痛の性質と立ち上がり能力の違いによる身体機能の比較

    鈴木祐介, 飯島弘貴, 飯島弘貴, 飯島弘貴, 田代雄斗, 青山朋樹

    Japanese Journal of Rehabilitation Medicine  2018年  (公社)日本リハビリテーション医学会

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    開催年月日: 2018年

    記述言語:日本語  

  14. 慣性センサによる変形性膝関節症の動的機能診断

    飯島弘貴, 飯島弘貴, 飯島弘貴, 江口僚, 青山朋樹, 高橋正樹

    日本機械学会シンポジウム:スポーツ工学・ヒューマンダイナミクス講演論文集(CD-ROM)  2018年 

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    開催年月日: 2018年

  15. 慣性センサを用いた変形性膝関節症者の歩行診断と新治療コンセプト「GAIT」の提案

    飯島弘貴, 飯島弘貴, 飯島弘貴, 江口僚, 青山朋樹, 高橋正樹

    LIFE講演概要集(CD-ROM)  2018年 

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    開催年月日: 2018年

  16. 変形性膝関節症に対する間葉系幹細胞治療におけるリハビリテーション システマティックレビュー

    飯島弘貴, 飯島弘貴, 井所拓哉, 長井桃子, 伊藤明良, 太治野純一, 中畑晶博, 喜屋武弥, 張ジュエ, 王天舒, 黒木裕士, 青山朋樹

    日本理学療法学術大会(Web)  2017年  (公社)日本理学療法士協会

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    開催年月日: 2017年

    記述言語:日本語  

  17. 変形性膝関節症に対する間葉系幹細胞治療におけるリハビリテーション-臨床介入研究のシステマティックレビュー-

    飯島弘貴, 飯島弘貴, 井所拓哉, 井所拓哉, 黒木裕士, 青山朋樹

    日本軟骨代謝学会プログラム・抄録集  2017年 

     詳細を見る

    開催年月日: 2017年

  18. 微小重力環境によるラットの行動・動作の変化を遠心重力を用いて抑制する

    太治野純一, 伊藤明良, 長井桃子, 張項凱, 山口将希, 山口将希, 飯島弘貴, 飯島弘貴, 喜屋武弥, 青山朋樹, 黒木裕士

    日本宇宙航空環境医学会大会プログラム・予稿集  2017年 

     詳細を見る

    開催年月日: 2017年

  19. 関節固定が変形性膝関節症の関節構成体に与える影響 関節症モデル動物を用いた実験研究(パイロットスタディ)

    飯島弘貴, 飯島弘貴, 長井桃子, 伊藤明良, 太治野純一, 中畑晶博, 喜屋武弥, 張ジュエ, 王天舒, 青山朋樹, 黒木裕士

    日本理学療法学術大会(Web)  2017年  (公社)日本理学療法士協会

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    開催年月日: 2017年

    記述言語:日本語  

  20. 膝関節可動域制限は広範囲関節症変化の引き金となりうる-関節症モデル動物を用いた実験研究-

    飯島弘貴, 飯島弘貴, 谷間桃子, 内山綺紗良, 伊藤明良, 太治野純一, 中畑晶博, 喜屋武弥, 張ジュエ, 季翔, 王天舒, 青山朋樹, 西谷江平, 高橋正樹, 高橋正樹, 黒木裕士

    日本整形外科学会雑誌  2017年  (公社)日本整形外科学会

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    開催年月日: 2017年

    記述言語:日本語  

  21. 環境温度がラット核心温度・外層温度および活動量に及ぼす影響

    伊藤明良, 太治野純一, 飯島弘貴, 長井桃子, 中畑晶博, 張ジュエ, 王天舒, 喜屋武弥, 青山朋樹, 黒木裕士

    日本理学療法学術大会(Web)  2017年  (公社)日本理学療法士協会

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    開催年月日: 2017年

    記述言語:日本語  

  22. 末梢神経損傷患者への幹細胞を用いた治療におけるリハビリテーション-システマティックレビューによる現状把握-

    長井桃子, 飯島弘貴, 伊藤明良, 太治野純一, 中畑晶博, 喜屋武弥, 張ジュエ, 王天舒, 青山朋樹, 黒木裕士

    日本理学療法学術大会(Web)  2017年  (公社)日本理学療法士協会

     詳細を見る

    開催年月日: 2017年

    記述言語:日本語  

  23. ラット変形性膝関節症モデルに対する強度別の運動刺激が関節軟骨-軟骨下骨複合体に与える影響

    飯島弘貴, 飯島弘貴, 青山朋樹, 伊藤明良, 伊藤明良, 山口将希, 山口将希, 長井桃子, 太治野純一, 張項凱, 喜屋武弥, 黒木裕士

    日本理学療法学術大会(Web)  2016年  (公社)日本理学療法士協会

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    開催年月日: 2016年

    記述言語:日本語  

  24. 均質な関節軟骨領域を求めて-物理的刺激効果検証に用いる関節軟骨部位の検討-

    伊藤明良, 伊藤明良, 飯島弘貴, 飯島弘貴, 太治野純一, 長井桃子, 山口将希, 山口将希, 張項凱, 喜屋武弥, 青山朋樹, 黒木裕士

    日本理学療法学術大会(Web)  2016年  (公社)日本理学療法士協会

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    開催年月日: 2016年

    記述言語:日本語  

  25. 内側半月板損傷が膝蓋大腿関節へ及ぼす影響-ラット変形性膝関節症モデルを用いた実験研究-

    中畑晶博, 青山朋樹, 飯島弘貴, 伊藤明良, 山口将希, 長井桃子, 太治野純一, 喜屋武弥, 張ジュエ, 王天舒, 黒木裕士

    運動器リハビリテーション  2016年  日本運動器科学会

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    開催年月日: 2016年

    記述言語:日本語  

  26. 中等度レベルのトレッドミル運動は変形性膝関節症の進行を遅らせる-ラット変形性膝関節症モデルを用いた実験研究-

    飯島弘貴, 飯島弘貴, 青山朋樹, 伊藤明良, 山口将希, 長井桃子, 太治野純一, 喜屋武弥, 中畑晶博, 張ジュエ, 王天舒, 黒木裕士

    運動器リハビリテーション  2016年  日本運動器科学会

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    開催年月日: 2016年

    記述言語:日本語  

  27. ラット膝関節不動モデルに対する荷重と非荷重が軟骨硬度に及ぼす影響

    長井桃子, 飯島弘貴, 伊藤明良, 太治野純一, 山口将希, 張項凱, 喜屋武弥, 青山朋樹, 黒木裕士

    日本理学療法学術大会(Web)  2016年  (公社)日本理学療法士協会

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    開催年月日: 2016年

    記述言語:日本語  

  28. ラット膝関節8週間不動後の自由飼育で見られた嚢胞様軟骨変性像に関する報告

    長井桃子, 伊藤明良, 太治野純一, 山口将希, 飯島弘貴, 張項凱, 喜屋武弥, 青山朋樹, 黒木裕士, 山田重人, 山田重人

    日本解剖学会総会・全国学術集会講演プログラム・抄録集  2016年 

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    開催年月日: 2016年

  29. ラット変形性膝関節症モデルに対する強度別の運動刺激が関節軟骨-軟骨下骨複合体に与える影響

    飯島弘貴, 飯島弘貴, 青山朋樹, 伊藤明良, 伊藤明良, 山口将希, 山口将希, 長井桃子, 太治野純一, ZHANG Xiangkai, 喜屋武弥, 黒木裕士

    日本軟骨代謝学会プログラム・抄録集  2016年 

     詳細を見る

    開催年月日: 2016年

  30. 変形性膝関節症患者における活動量と身体機能の関係性

    飯島弘貴, 福谷直人, 井所拓哉, 山本裕子, 平岡正和, 宮信和幸, 陳之内将志, 金田瑛司, 金田瑛司, 青山朋樹, 松田秀一, 黒木裕士

    日本理学療法学術大会(Web)  2016年  (公社)日本理学療法士協会

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    開催年月日: 2016年

    記述言語:日本語  

  31. 骨軟骨欠損モデルラットに対する細胞移植と低出力超音波パルス治療の併用が欠損修復に及ぼす影響

    山口将希, 山口将希, 青山朋樹, 伊藤明良, 伊藤明良, 飯島弘貴, 飯島弘貴, 長井桃子, 太治野純一, 張項凱, 黒木裕士

    日本理学療法学術大会(Web)  2016年  (公社)日本理学療法士協会

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    開催年月日: 2016年

    記述言語:日本語  

  32. 微小重力環境によるラットの活動量リズム変化を遠心重力を用いて抑制する

    太治野純一, 伊藤明良, 長井桃子, 張項凱, 山口将希, 山口将希, 飯島弘貴, 飯島弘貴, 喜屋武弥, 青山朋樹, 黒木裕士

    日本宇宙航空環境医学会大会プログラム・予稿集  2016年  日本宇宙航空環境医学会

     詳細を見る

    開催年月日: 2016年

    記述言語:日本語  

  33. 後肢免荷に対する高重力介入がラットの歩容変化に与える影響

    太治野純一, 伊藤明良, 伊藤明良, 長井桃子, 張項凱, 山口将希, 山口将希, 飯島弘貴, 飯島弘貴, 喜屋武弥, 青山朋樹, 黒木裕士

    日本理学療法学術大会(Web)  2016年  (公社)日本理学療法士協会

     詳細を見る

    開催年月日: 2016年

    記述言語:日本語  

  34. 8週間の関節不動後の自由飼育が関節軟骨に与える影響~嚢胞様軟骨変性像の形成過程に関する報告~

    長井桃子, 伊藤明良, 太治野純一, 山口将希, 飯島弘貴, 張項凱, 喜屋武弥, 青山朋樹, 黒木裕士

    日本理学療法学術大会(Web)  2015年  (公社)日本理学療法士協会

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    開催年月日: 2015年

    記述言語:日本語  

  35. レントゲン画像所見と歩行観察に基づく内側型変形性膝関節症サブグループ作成の試み

    飯島弘貴, 福谷直人, 青山朋樹, 山本裕子, 平岡正和, 宮信和幸, 陳之内将志, 金田瑛司, 松田秀一, 黒木裕士

    日本理学療法学術大会(Web)  2015年  (公社)日本理学療法士協会

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    開催年月日: 2015年

    記述言語:日本語  

  36. 半月板損傷モデルラットに対する軽度な運動負荷が関節軟骨,軟骨下骨に与える影響の検討

    飯島弘貴, 青山朋樹, 伊藤明良, 山口将希, 長井桃子, 太治野純一, ZHANG Xiangkai, 喜屋武弥, 黒木裕士

    日本軟骨代謝学会プログラム・抄録集  2015年 

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    開催年月日: 2015年

  37. 低出力超音波パルスは骨軟骨欠損モデルラットの軟骨再生に影響を及ぼすか?

    山口将希, 山口将希, 青山朋樹, 伊藤明良, 伊藤明良, 長井桃子, 太治野純一, 飯島弘貴, ZHANG Xhangkai, 喜屋武弥, 黒木裕士

    超音波骨折治療研究会プログラム・抄録集  2015年 

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    開催年月日: 2015年

  38. 変形性膝関節症患者における外側スラストの出現は安静時痛,動作時痛,日常生活動作の困難さに影響する

    福谷直人, 飯島弘貴, 青山朋樹, 山本裕子, 平岡正和, 宮信和幸, 陳之内将志, 金田瑛司, 坪山直生, 松田秀一

    日本理学療法学術大会(Web)  2015年  (公社)日本理学療法士協会

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    開催年月日: 2015年

    記述言語:日本語  

  39. 骨軟骨欠損モデルラットに対する間葉系間質細胞移植と低出力超音波パルス治療の併用による骨軟骨再生効果の検討

    山口将希, 山口将希, 伊藤明良, 伊藤明良, 太治野純一, 長井桃子, 飯島弘貴, 張項凱, 喜屋武弥, 青山朋樹, 黒木裕士

    日本理学療法学術大会(Web)  2015年  (公社)日本理学療法士協会

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    開催年月日: 2015年

    記述言語:日本語  

  40. 間欠的な温熱刺激を用いたヒト軟骨細胞による関節軟骨基質生成の試み-三次元培養を用いたin vitro研究-

    伊藤明良, 伊藤明良, 太治野純一, 長井桃子, 山口将希, 飯島弘貴, 張項凱, 喜屋武弥, 青山朋樹, 黒木裕士

    日本理学療法学術大会(Web)  2015年  (公社)日本理学療法士協会

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    開催年月日: 2015年

    記述言語:日本語  

  41. 運動負荷は損傷した軟骨下骨を治癒させ変形性膝関節症の進行予防に寄与する 二次性変形性膝関節症モデルラットを用いたin vivo研究

    飯島弘貴, 青山朋樹, 伊藤明良, 山口将希, 長井桃子, 太治野純一, 張項凱, 喜屋武弥, 黒木裕士

    日本理学療法学術大会(Web)  2015年  (公社)日本理学療法士協会

     詳細を見る

    開催年月日: 2015年

    記述言語:日本語  

  42. 微小重力環境に対する遠心人工重力介入がラットの歩行パターン変化に与える影響

    太治野純一, 伊藤明, 伊藤明, 長井桃子, 張項凱, 山口将希, 山口将希, 飯島弘貴, 飯島弘貴, 喜屋武弥, 青山朋樹, 黒木裕士

    日本宇宙航空環境医学会大会プログラム・予稿集  2015年  日本宇宙航空環境医学会

     詳細を見る

    開催年月日: 2015年

    記述言語:日本語  

  43. 外側スラストに対する治療介入の可能性-Japan Thrust Contest-

    福谷直人, 飯島弘貴, 青山朋樹

    日本理学療法学術大会(Web)  2015年  (公社)日本理学療法士協会

     詳細を見る

    開催年月日: 2015年

    記述言語:日本語  

  44. 8週間の関節不動により変性した軟骨は,不動解除後に変性が助長される

    長井桃子, 青山朋樹, 伊藤明良, 山口将希, 飯島弘貴, 太治野純一, 張項凱, 秋山治彦, 黒木裕士

    日本理学療法学術大会(Web)  2014年  (公社)日本理学療法士協会

     詳細を見る

    開催年月日: 2014年

    記述言語:日本語  

  45. ラットOAモデルに対する運動の軟骨変性予防効果

    飯島弘貴, 青山朋樹, 伊藤明良, 太治野純一, 長井桃子, ZHANG Xiangkai, 山口将希, 秋山治彦, 黒木裕士

    日本軟骨代謝学会プログラム・抄録集  2014年 

     詳細を見る

    開催年月日: 2014年

  46. 免荷による歩容変化は再荷重によっても回復しない 後肢免荷がラットの歩容に与える影響

    太治野純一, 伊藤明良, 張項凱, 長井桃子, 山口将希, 飯島弘貴, 青山朋樹, 黒木裕士

    日本理学療法学術大会(Web)  2014年  (公社)日本理学療法士協会

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    開催年月日: 2014年

    記述言語:日本語  

  47. 変形性関節症に対する効果的なユビキタス治療法の開発

    黒木裕士, 青山朋樹, 長井桃子, 山口将希, 飯島弘貴, 伊藤明良

    大阪ガスグループ福祉財団調査・研究報告集  2014年 

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    開催年月日: 2014年

  48. 骨髄由来間葉系間質細胞移植治療後の運動介入が欠損した関節軟骨再生に及ぼす影響

    山口将希, 青山朋樹, 伊藤明良, 長井桃子, 飯島弘貴, 太治野純一, 張項凱, 黒木裕士

    再生医療  2014年 

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    開催年月日: 2014年

  49. 骨髄由来間葉系間質細胞移植治療と運動との併用は骨軟骨欠損した関節軟骨の再生を促進する

    山口将希, 青山朋樹, 伊藤明良, 長井桃子, 太治野純一, 飯島弘貴, 張項凱, 秋山治彦, 黒木裕士

    日本理学療法学術大会(Web)  2014年  (公社)日本理学療法士協会

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    開催年月日: 2014年

    記述言語:日本語  

  50. 関節軟骨基質再生のための至適温度の探究-三次元培養を用いたin vitro研究-

    伊藤明良, 伊藤明良, 青山朋樹, 長井桃子, 太治野純一, 山口将希, 飯島弘貴, 張項凱, 秋山治彦, 黒木裕士

    日本理学療法学術大会(Web)  2014年  (公社)日本理学療法士協会

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    開催年月日: 2014年

    記述言語:日本語  

  51. 膝関節拘縮後の軟骨基質変化-超微細構造からの検討-

    長井桃子, 伊藤明良, 太治野純一, 飯島弘貴, 山口将希, ZHANG Xiangkai, 青山朋樹, 秋山治彦, 黒木裕士

    日本軟骨代謝学会プログラム・抄録集  2014年 

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    開催年月日: 2014年

  52. 精密微細射出成形培養皿による間葉系幹細胞配向性の導出

    張項凱, 安田崇志, 尾池真, 藤岡瑠音, 伊藤明良, 長井桃子, 太治野純一, 山口将希, 飯島弘貴, 柿沼憲宏, 青山朋樹, 黒木裕士

    再生医療  2014年 

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    開催年月日: 2014年

  53. 温度環境は軟骨細胞外基質形成能に影響を与える-ヒト軟骨細胞を用いたin vitro研究-

    伊藤明良, 伊藤明良, 青山朋樹, 長井桃子, 太治野純一, 山口将希, 飯島弘貴, ZHANG Xiangkai, 秋山治彦, 黒木裕士

    日本軟骨代謝学会プログラム・抄録集  2014年 

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    開催年月日: 2014年

  54. 変形性関節症モデルラットに対する緩徐な走行運動は軟骨下骨変化を予防できるのか?

    飯島弘貴, 青山朋樹, 伊藤明良, 長井桃子, 山口将希, 太治野純一, 張項凱, 秋山治彦, 黒木裕士

    日本理学療法学術大会(Web)  2014年  (公社)日本理学療法士協会

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    開催年月日: 2014年

    記述言語:日本語  

  55. 下肢および頭部の血流動態に注目した空気圧免荷トレッドミル歩行の安全性の検証

    太治野純一, 伊藤明良, 鳥居勇輔, 土本浩司, 飯島弘貴, 張項凱, 長井桃子, 山口将希, 家城弘, 南角学, 柿木良介, 井上大輔, 広瀬太希, 黒木裕士

    日本理学療法学術大会(Web)  2013年  (公社)日本理学療法士協会

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    開催年月日: 2013年

    記述言語:日本語  

  56. 寒冷刺激が変形性膝関節症ラットの関節軟骨に及ぼす影響

    山口将希, 伊藤明良, 長井桃子, 張項凱, 飯島弘貴, 太治野純一, 青山朋樹, 秋山治彦, 広瀬太希, 井上大輔, 黒木裕士

    日本理学療法学術大会(Web)  2013年  (公社)日本理学療法士協会

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    開催年月日: 2013年

    記述言語:日本語  

  57. 関節軟骨におけるHSP70の発現局在の解明と荷重量の変化が及ぼす影響

    広瀬太希, 飯島弘貴, 伊藤明良, 長井桃子, 山口将希, 太治野純一, 張項凱, 井上大輔, 青山朋樹, 秋山治彦, 黒木裕士

    日本理学療法学術大会(Web)  2013年  (公社)日本理学療法士協会

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    開催年月日: 2013年

    記述言語:日本語  

  58. 軟骨細胞に対する長期温熱刺激の安全性と軟骨基質生合成へ与える影響の検討

    伊藤明良, 伊藤明良, 青山朋樹, 長井桃子, 山口将希, 飯島弘貴, 太治野純一, 張項凱, 井上大輔, 広瀬太希, 秋山治彦, 黒木裕士

    日本理学療法学術大会(Web)  2013年  (公社)日本理学療法士協会

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    開催年月日: 2013年

    記述言語:日本語  

  59. 膝関節不動が関節軟骨におけるCD44発現に及ぼす影響

    長井桃子, 伊藤明良, 山口将希, 飯島弘貴, 太治野純一, 張項凱, 井上大輔, 広瀬太希, 青山朋樹, 黒木裕士

    日本理学療法学術大会(Web)  2013年  (公社)日本理学療法士協会

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    開催年月日: 2013年

    記述言語:日本語  

  60. 膝半月板被覆部の軟骨・骨複合体は構造的に脆弱である

    飯島弘貴, 青山朋樹, 伊藤明良, 太治野純一, 張項凱, 長井桃子, 山口将希, 広瀬太希, 井上大輔, 秋山治彦, 黒木裕士

    日本理学療法学術大会(Web)  2013年  (公社)日本理学療法士協会

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    開催年月日: 2013年

    記述言語:日本語  

  61. 尾部懸垂モデルラットに対する懸垂中断時間が,骨強度,骨密度に与える影響

    井上大輔, 飯島弘貴, 伊藤明良, 長井桃子, 山口将希, 太治野純一, 張項凱, 広瀬太希, 青山朋樹, 秋山治彦, 黒木裕士

    日本理学療法学術大会(Web)  2013年  (公社)日本理学療法士協会

  62. 超高齢社会を健康長寿社会へ リハビリテーションを軸とした新学際領域への挑戦 招待有り

    飯島 弘貴

    第1回ヘルスサイエンス研究会  2022年4月27日 

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    記述言語:日本語   会議種別:口頭発表(基調)  

  63. NOTUM -- Transcriptomic Evidence of an Exercise-Responsive Myokine Toward the Preservation of Bone Health: An Exploratory Study

    Iijima H, Chowdhary K, Ambrosio F

    Physiatry’21  2021年2月 

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    記述言語:英語   会議種別:ポスター発表  

  64. Moderate to Severe LBP was Associated with Recurrent Falls in People with Knee Osteoarthritis

    Iijima H, Shimoura K, Aoyama T, Takahashi M

    ORS 2020 Annual Meeting  2020年2月 

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    記述言語:英語   会議種別:ポスター発表  

  65. Mild thermal environment enhances redifferentiation and cartilage extracellular matrix formation of expanded elderly human chondrocytes

    Ito A, Yamaguchi A, Tajino J, Nagai M, Iijima H, Zhang X, Aoyama T, Kuroki H

    Third Annual Symposium on Regenerative Rehabilitation  2014年4月 

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    記述言語:英語   会議種別:ポスター発表  

  66. Markerless Mobility Assessment Techniques Toward an Establishment of Outcome Measures of Regenerative Rehabilitation for Knee Osteoarthritis

    Iijima H, Eguchi R, Yorozu A, Aoyama T, Takahashi M

    7th Annual International Symposium on Regenerative Rehabilitation  2018年11月 

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    記述言語:英語   会議種別:ポスター発表  

  67. Is cartilage and subchondral bone covered by menisci weak?

    Iijima H, Aoyama T, Ito A, Tajino J, Nagai M, Zhang X, Yamaguchi S, Akiyama H, Kuroki H

    2013 World Congress on Osteoarthritis  2013年4月 

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    記述言語:英語   会議種別:ポスター発表  

  68. Intermittent gravitation by centrifuge counteracts against the gait alteration in rats induced by two-week simulated microgravity

    Tajino J, Ito A, Nagai M, Zhang X, Yamaguchi S, Iijima H, Aoyama T, Kuroki H

    20th IAA Humans in Space  2015年6月 

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    記述言語:英語   会議種別:口頭発表(一般)  

  69. Intermittent centrifugation attenuates the disruption of rat walking induced by 2-week hind limb unloading

    Tajino J, Ito A, Nagai M, Zhang X, Yamaguchi S, Iijima H, Aoyama T, Kuroki H

    35th Annual International Gravitational Physiology Meeting  2014年6月 

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    記述言語:英語   会議種別:口頭発表(一般)  

  70. Integrated approach of meta-analysis and bioinformatics towards elucidating disease mechanisms associated with age-related knee osteoarthritis

    Iijima H, Gilmer G, Wang K, Sivakumar S, Matsui Y, Ambrosio F

    OARSI Connect’21  2021年4月 

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    記述言語:英語   会議種別:口頭発表(一般)  

  71. Influence of knee pain on various activities of daily living may reduce physical activity in patients with knee osteoarthritis according to disease severity

    Fukutani N, Iijima H, Fukumoto T, Uritani D, Kaneda E, Ota K, Aoyama T, Tsuboyama T, Matsuda S

    9th World Congress of the International Society of Physical and Rehabilitation Medicine  2015年6月 

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    記述言語:英語   会議種別:ポスター発表  

  72. Identifying the optimal dose of the intermittent gravitation to attenuate the alteration of rat’s walking induced by 2-week simulated microgravity

    Tajino J, Ito A, Nagai M, Zhang X, Yamaguchi S, Iijima H, Aoyama T, Kuroki H

    36th Annual International Gravitational Physiology Meeting  2015年6月 

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    記述言語:英語   会議種別:ポスター発表  

  73. Gait kinematics changes in post-traumatic knee osteoarthritis with destabilized medial meniscus in rat

    Nakahata A, Iijima H, Tanima-Nagai M, Ito A, Tajino J, Kiyan W, Zhang J, Ji X, Wang T, Aoyama T, Nishitani K, Kuroki H

    2018 World Congress on Osteoarthritis  2018年4月 

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    記述言語:英語   会議種別:ポスター発表  

  74. Gait Analysis Of Patients With Distal Radius Fracture Using A Novel Laser-tug System

    Fujita K, Iijima H, Okumura A, Yao Y, Nimura A, Kato R, Okawa A, Takahashi M

    ACSM’s annual meeting  2019年5月 

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    記述言語:英語   会議種別:ポスター発表  

  75. Functional manifestation in patients with early knee osteoarthritis toward the preservation of joint health: A systematic review and meta-analysis

    Kanako S, Shimizu H, Iijima H, Suzuki Y, Aoyama T

    OARSI Connect’21  2021年4月 

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    記述言語:英語   会議種別:ポスター発表  

  76. Efficacy of LIPUS treatment following mesenchymal stromal cell intra-articular injection in an osteochondral defect model rats

    Yamaguchi S, Aoyama T, Ito A, Nagai M, Iijima H, Tajino J, Zhang X, Kiyan W, Kuroki H

    Fourth Annual Symposium on Regenerative Rehabilitation  2015年9月 

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    記述言語:英語   会議種別:ポスター発表  

  77. Efficacy of exercise following bone marrow mesenchymal stromal cell transplantation in an osteochondral defect model of rats

    Yamaguchi S, Aoyama T, Ito A, Nagai M, Iijima H, Tajino J, Zhang X, Akiyama H, Kuroki H

    Third Annual Symposium on Regenerative Rehabilitation  2014年4月 

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    記述言語:英語   会議種別:ポスター発表  

  78. Effects of Transcutaneous Electrical Nerve Stimulation on Stair Climbing Capacity: a Secondary Analysis of Randomized Controlled Trial

    Iijima H, Eguchi R, Shimoura K, Aoyama T, Takahashi M

    ORS 2019 Annual Meeting  2019年2月 

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    記述言語:英語   会議種別:ポスター発表  

  79. Effects of the combined therapy of rehabilitation with cell therapy on motor functional recovery after cerebral infarction: A systematic review

    Kubo N, Ito A, Shimogawa T, Iiijima H, Wang T, Aoyama T, Kuroki H

    7th Annual International Symposium on Regenerative Rehabilitation  2018年11月 

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    記述言語:英語   会議種別:ポスター発表  

  80. Effectiveness of Mesenchymal Stem Cells for Treating Patients with Knee Osteoarthritis: A Meta-analysis Toward the Establishment of Effective Regenerative Rehabilitation

    Iijima H, Isho T, Kuroki H, Takahashi M, Aoyama T

    7th Annual International Symposium on Regenerative Rehabilitation  2018年11月 

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    記述言語:英語   会議種別:ポスター発表  

  81. Effect of unweight-bearing for mechanical properties and ultrastructure of collagen in articular cartilage

    Iijima H, Aoyama T, Ito A, Tajino J, Nagai M, Zhang X, Yamaguchi S, Kuroki H

    The 6th Asia-Western Pacific Regional Congress of the World Confederation for Physical Therapy (WCPT) & The 12th International Congress of Asian Confederation for Physical Therapy (ACPT) Congress 2013  2013年9月 

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    記述言語:英語   会議種別:ポスター発表  

  82. Effect of initiation timing of gentle treadmill exercise on cartilage and subchondral bone in a model of destabilization of medial meniscus of rats

    Iijima H, Aoyama T, Ito A, Yamaguchi S, Nagai M, Tajino J, Zhang X, Kiyan W, Kuroki H

    2015 World Congress on Osteoarthritis  2015年4月 

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    記述言語:英語   会議種別:ポスター発表  

  83. Dynamic regulation of bone morphogenetic proteins by gentle treadmill walking potentially prevent progression of osteoarthritis in a rat model of destabilized medial meniscus

    Iijima H, Aoyama T, Ito A, Tajino J, Yamaguchi S, Nagai M, Zhang X, Kiyan W, Kuroki H

    Fourth Annual Symposium on Regenerative Rehabilitation  2015年9月 

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    記述言語:英語   会議種別:ポスター発表  

  84. Culturing temperature affects chondrocyte differentiation and extracellular matrix formation and redifferentiation of expanded human chondrocyte

    Ito A, Aoyama T, Tajino J, Nagai M, Yamaguchi S, Iijima H, Zhang X, Akiyama H, Kuroki H

    2014 World Congress on Osteoarthritis  2014年4月 

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    記述言語:英語   会議種別:ポスター発表  

  85. Culturing temperature affects chondrocyte differentiation and extracellular matrix formation

    Ito A, Aoyama T, Tajino J, Nagai M, Yamaguchi S, Iijima H, Zhang X, Akiyama H, Kuroki H

    2013 World Congress on Osteoarthritis  2013年4月 

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    記述言語:英語   会議種別:ポスター発表  

  86. Contribution of biarticular myogenic components to limitation of range of motion after joint immobility

    Nagai M, Ito A, Yamaguchi S, Iijima H, Zhang X, Tajino J, Aoyama T, Kuroki H

    Asia-Western Pacific Regional Congress of the World Confederation for Physical Therapy (WCPT) & International Congress of Asian Confederation for Physical Therapy (ACPT) Congress 2013  2013年9月 

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    記述言語:英語   会議種別:ポスター発表  

  87. Concurrent Validity and Measurement Error of Stair Climb Test in Individuals with Knee Osteoarthritis

    Iijima H, Shimoura K, Eguchi R, Aoyama T, Takahashi M

    23th Annual Meeting of the Japanese Association of Physical Therapy Fundamentals  2018年12月 

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    記述言語:英語   会議種別:口頭発表(一般)  

  88. Changes on the expression of CD44 in immobilized knee in rats

    Nagai M, Ito A, Zhang X, Yamaguchi S, Iijima H, Tajino J, Aoyama T, Kuroki H

    2013 World Congress on Osteoarthritis  2013年4月 

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    記述言語:英語   会議種別:ポスター発表  

  89. Cartilage degeneration in immobilization rat knee joint deteriorated with re-mobilization

    Nagai M, Aoyama T, Ito A, Tajino J, Yamaguchi A, Iijima H, Zhang X, Akiyama H, Kuroki H

    Third Annual Symposium on Regenerative Rehabilitation  2014年4月 

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    記述言語:英語   会議種別:ポスター発表  

  90. Biomechanical Characteristics of Stair Ambulation in Patients with Knee OA: A Systematic Review with Meta-analysis Toward A Better Definition of Clinical Hallmarks

    Iijima H, Shimoura K, Aoyama T, Takahashi M

    2018 World Congress on Osteoarthritis  2018年4月 

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    記述言語:英語   会議種別:ポスター発表  

  91. Assessment on the effects of high and low in vivo cyclic compressive loading on the progression of cartilage degeneration in rat knee joint

    Ji X, Nakahata A, Ito A, Iijima H, Tajino J, Tanima-Nagai M, Kiyan W, Zhang J, Wang T, Nishitani K, Aoyama T, Kuroki H

    2018 World Congress on Osteoarthritis  2018年4月 

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    記述言語:英語   会議種別:ポスター発表  

  92. Age-related increase in matrix stiffness downregulates α-Klotho in cartilage and induces cartilage degeneration.

    Iijima H, Gilmer G, Wang K, Bean A, Ambrosio F

    OARSI Connect’21  2021年4月 

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    記述言語:英語   会議種別:口頭発表(一般)  

  93. Age attenuates the benefits of platelet-rich plasma on chondrocyte health

    Chowdhary K, Sahu A, Iijima H, Miller A, Bean A, Ambrosio F

    Physiatry’21  2021年2月 

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    記述言語:英語   会議種別:ポスター発表  

  94. Acceleration patterns of the trunk during walking in individuals with varus thrust: toward an estabilishment of the pathomechanics of varus thrust

    Iijima H, Eguchi R, Aoyama T, Takahashi M

    2018 World Congress on Osteoarthritis  2018年4月 

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    記述言語:英語   会議種別:ポスター発表  

  95. Novel Locomotive Assessment for Knee Osteoarthritis: Laser-TUG

    Iijima H, Yorozu A, Suzuki Y, Eguchi R, Aoyama T, Takahashi M

    ORS 2019 Annual Meeting  2019年2月 

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    記述言語:英語   会議種別:ポスター発表  

  96. Waist-Mounted Sensor Algorithm for Gait Events Detection: A Scoping Review

    Iijima H, Takahashi M

    ORS 2020 Annual Meeting  2020年2月 

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    記述言語:英語   会議種別:ポスター発表  

  97. Trunk movement asymmetry was associated with pain, disability, and quadriceps strength asymmetry in individuals with knee osteoarthritis: a cross-sectional study

    Iijima H, Eguchi R, Aoyama T, Takahashi M

    ORS 2019 Annual Meeting  2019年2月 

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    記述言語:英語   会議種別:ポスター発表  

  98. Treadmill exercise post bone marrow mesenchymal stromal cells transplantation stimulated the regeneration of articular cartilage on rat knee joint osteochondral defect

    Yamaguchi S, Aoyama T, Ito A, Nagai M, Iijima H, Tajino J, Zhang X, Akiyama H, Kuroki H

    2014 World Congress on Osteoarthritis  2014年4月 

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    記述言語:英語   会議種別:口頭発表(一般)  

  99. The Role of Mechanical Force in Tendon Development: A Scoping Review

    Usami Y, Iijima H, Kokubun T

    OARSI Connect’21  2021年4月 

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    記述言語:英語   会議種別:ポスター発表  

  100. The limited knee range of motion causes progression of cartilage degeneration in the osteoarthritic knee joint: an experimental study using a preclinical model of osteoarthritis

    Iijima H, Tanima-Nagai M, Uchiyama K, Ito A, Tajino J, Nakahata A, Kiyan W, Zhang J, Ji X, Wang T, Aoyama T, Nishitani K, Takahashi M, Kuroki H

    2018 World Congress on Osteoarthritis  2018年4月 

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    記述言語:英語   会議種別:ポスター発表  

  101. The influence of re-mobilization on altered cartilage induced by joint immobilization - pathological process of the cyst formation -

    Nagai M, Ito A, Tajino J, Zhang X, Yamaguchi S, Iijima H, Kiyan W, Aoyama T, Kuroki H

    2015 World Congress on Osteoarthritis  2015年4月 

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    記述言語:英語   会議種別:ポスター発表  

  102. The effect of low intensity pulsed ultrasound treatment combined with mesenchymal stromal cell injection for cartilage regeneration in a knee osteochondral defect model of rats

    Yamaguchi S, Aoyama T, Ito A, Nagai M, Iijima H, Tajino J, Zhang X, Kiyan W, Kuroki H

    2015 World Congress on Osteoarthritis  2015年4月 

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    記述言語:英語   会議種別:ポスター発表  

  103. The association of declining klotho expression with an onset of knee osteoarthritis in pre-clinical model and human samples

    Iijima H, He Y, Wang N, Lin H, Ambrosio F

    2020 World Congress on Osteoarthritis  2020年4月 

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    記述言語:英語   会議種別:口頭発表(一般)  

  104. Specific contribution of hip abductor muscle strength to turning movement in individuals with knee osteoarthritis

    Iijima H, Yorozu A, Suzuki Y, Eguchi R, Aoyama T, Takahashi M

    2018 World Congress on Osteoarthritis  2018年4月 

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    記述言語:英語   会議種別:ポスター発表  

  105. Slower belt, but still enough adaptation ~the extent of a “broken escalator phenomenon”~

    Tajino J, Ito A, Nagai M, Zhang X, Yamaguchi S, Iijima H, Kuroki H

    American Physical Therapy Association (APTA) Combined Sections Meeting (CSM)  2014年2月 

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    記述言語:英語   会議種別:ポスター発表  

  106. Slowed turning speed in knee osteoarthritis patients with weaker hip abductor muscle

    Iijima H, Yorozu A, Suzuki Y, Eguchi R, Aoyama T, Takahashi M

    23th Annual Meeting of the Japanese Association of Physical Therapy Fundamentals  2018年12月 

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    記述言語:英語   会議種別:口頭発表(一般)  

  107. Site specific influence of weight or non-weight bearing condition on the stiffness of the cartilage during short-term immobilization intervention on rat knee joint

    Nagai M, Iijima H, Tajino J, Yamaguchi S, Zhang X, Kiyan W, Aoyama T, Kuroki H

    2016 World Congress on Osteoarthritis  2015年3月 

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    記述言語:英語   会議種別:ポスター発表  

  108. Sarcopenic Knee Osteoarthritis: A Risk Factor for Recurrent Falls

    Iijima H, Aoyama T

    ORS 2020 Annual Meeting  2020年2月 

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    記述言語:英語   会議種別:ポスター発表  

  109. Role of the Anti-Aging Factor Alpha-Klotho in Aging-related Knee Osteoarthritis: A Pilot Study

    Iijima H, Wang N, Lin H, Ambrosio F

    8th Annual International Symposium on Regenerative Rehabilitation  2019年11月 

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    記述言語:英語   会議種別:ポスター発表  

  110. Risk-benefit balance of repetitive physical exercise on osteoarthritic articular cartilage: a cross-cutting systematic review of human, in vivo, and ex vivo studies

    Iijima H, Sonoo M, Yamashita T

    23th Annual Meeting of the Japanese Association of Physical Therapy Fundamentals  2018年12月 

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    記述言語:英語   会議種別:口頭発表(一般)  

  111. Reloading does not attenuate the hindlimb unload-induced gait alteration: The influence of tail suspension to gait pattern of rats

    Tajino J, Ito A, Zhang X, Nagai M, Yamaguchi S, Iijima H, Aoyama T, Kuroki H

    2014 World Congress on Osteoarthritis  2014年4月 

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    記述言語:英語   会議種別:ポスター発表  

  112. Relationship Between Varus Thrust During Gait and Low Back Pain in People with Knee Osteoarthritis

    Iijima H, Suzuki Y, Aoyama T, Matsuda S, Takahashi M

    ORS 2019 Annual Meeting  2019年2月 

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    記述言語:英語   会議種別:ポスター発表  

  113. Rehabilitative Exercise-driven Cartilage Regeneration: A Cross-Cutting Systematic Review from Ex Vivo, Animal, and Clinical Trials

    Iijima H, Sonoo M

    8th Annual International Symposium on Regenerative Rehabilitation  2019年11月 

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    記述言語:英語   会議種別:ポスター発表  

  114. Rehabilitation program after mesenchymal stem cell therapy in patients with knee osteoarthritis –a systematic review of clinical study-

    Iijima H, Isho T, Kuroki H, Aoyama T

    The 30th Annual Meeting of the Japanese Society of Cartilage Metabolism  2017年3月 

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    記述言語:英語   会議種別:口頭発表(一般)  

  115. Rehabilitation After Osteochondral Autograft Transplantation: A Single Case Report

    Iijima H, Takeda T, Harada S, Iwadate D, Otsuka K

    7th Annual International Symposium on Regenerative Rehabilitation  2018年11月 

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    記述言語:英語   会議種別:ポスター発表  

  116. Regional changes of early osteoarthritis cartilage and subchondral bone fracture in a rat knee model of OA

    Iijima H, Aoyama T, Ito A, Yamaguchi S, Nagai M, Tajino J, Zhang X, Akiyama H, Kuroki H

    2014 World Congress on Osteoarthritis  2014年4月 

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    記述言語:英語   会議種別:ポスター発表  

  117. Re-mobilization of knees aggravated cartilage degeneration in an immobilization model of rats

    Nagai M, Aoyama T, Ito A, Yamaguchi S, Iijima H, Tajino J, Zhang X, Akiyama H, Kuroki H

    2014 World Congress on Osteoarthritis  2014年4月 

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    記述言語:英語   会議種別:ポスター発表  

  118. Quadriceps strength in individuals with coexisting medial and lateral osteoarthritis: toward an identification of modifiable risk factors in important subgroup of mild radiographic disease

    Iijima H, Suzuki Y, Aoyama T, Takahashi M

    2018 World Congress on Osteoarthritis  2018年4月 

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    記述言語:英語   会議種別:ポスター発表  

  119. Proximal Gait Adaptations in Individuals with Medial Knee OA: A Systematic Review with Meta-analysis

    Iijima H, Takahashi M

    2018 World Congress on Osteoarthritis  2018年4月 

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    記述言語:英語   会議種別:ポスター発表  

  120. Poor Stair Climbing Capacity in Early Knee Osteoarthritis: Toward a Defining Clinical Hallmarks of Early Disease

    Iijima H, Eguchi R, Shimoura K, Aoyama T, Takahashi M

    ORS 2019 Annual Meeting  2019年2月 

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    記述言語:英語   会議種別:ポスター発表  

  121. Physiological exercise loading suppresses post-traumatic osteoarthritis progression via increase in bone morphogenetic proteins expression in an experimental rat knee model

    Iijima H, Ito A, Nagai M, Tajino J, Yamaguchi S, Kiyan W, Nakahata A, Zhang J, Wang T, Aoyama T, Nishitani K, Kuroki H

    2017 World Congress on Osteoarthritis  2017年4月 

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    記述言語:英語   会議種別:ポスター発表  

  122. Periodic heat stimulus for extracellular matrix production on human chondrocytes

    Ito A, Iijima H, Tajino J, Nagai M, Yamaguchi S, Zhang X, Aoyama T, Kuroki H

    Fourth Annual Symposium on Regenerative Rehabilitation  2015年9月 

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    記述言語:英語   会議種別:ポスター発表  

  123. People With Varus Thrust Less Responds to Home-Based Quadriceps Exercise on Pain Outcomes: A Secondary Subgroup Analysis From a Randomized Controlled Trial

    Iijima H, Suzuki Y, Aoyama T, Matsuda S, Takahashi M

    ORS 2019 Annual Meeting  2019年2月 

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    記述言語:英語   会議種別:ポスター発表  

  124. Patellofemoral osteoarthritis progression related with gait kinematics changes in rat with destabilized medial meniscus

    Nakahata A, Iijima H, Tanima-Nagai M, Ito A, Wang T, Nakahara R, Tajino J, Zhang J, Kawai H, Kubo N, Aoyama T, Kuroki H

    7th Annual International Symposium on Regenerative Rehabilitation  2018年11月 

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    記述言語:英語   会議種別:ポスター発表  

▼全件表示

共同研究・競争的資金等の研究課題 7

  1. 加齢性疾患をドライブするエピジェネティック制御機構の探求

    2022年4月 - 2027年3月

    世界的課題を解決する知の『開拓者』育成事業 

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    担当区分:研究代表者 

  2. Optimizing Muscle and Bone Mechanoadaptation to Physical Training: Understanding the Mechanistic Pathways via Muscle Bone Crosstalk to Altered Mechanical Loading

    2021年9月 - 2026年8月

    The U.S. Army Medical Research and Development Command Grant 

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    担当区分:研究分担者 

  3. From platelet dust to extracellular vesicles – the mechanistic study of platelet-rich plasma and its role in the treatment of osteoarthritis

    2020年11月 - 2021年10月

    Scott F. Nadler PASSOR Musculoskeletal Research Grant 

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    担当区分:研究分担者 

  4. 骨髄間葉系幹細胞移植に最適な関節内微小環境を目指すニッチェリハビリテーション

    2019年5月 - 2021年3月

    海外特別研究員 

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    担当区分:研究代表者 

  5. マルチセンサの有機的統合による運動器不安定症発症予測アルゴリズム開発

    2018年4月 - 2020年3月

    科学研究費助成事業 若手研究 

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    担当区分:研究代表者 

  6. 変形性膝関節症の動的診断システム開発によるテーラーメードリハビリテーションの創出

    2017年4月 - 2020年3月

    科学研究費助成事業 特別研究員奨励費 

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    担当区分:研究代表者 

  7. 変形性膝関節症モデルラットに対する運動負荷がもたらす病理組織学的変化

    2015年4月 - 2017年3月

    科学研究費助成事業 特別研究員奨励費 

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    担当区分:研究代表者 

▼全件表示

産業財産権 1

  1. Methods and materials for treating osteoarthritis

    Hirotaka Iijima, Fabrisia Ambrosio

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    出願番号:US Patent App. 17/236,726  出願日:2021年4月