2024/11/04 更新

写真a

イトウ タカヤス
伊藤 貴康
ITO Takayasu
所属
医学部附属病院 呼吸器内科 病院助教
職名
病院助教

学位 2

  1. 医学博士(短縮終了) ( 2022年3月   名古屋大学 ) 

  2. 学士 ( 2009年3月   岐阜大学 ) 

研究キーワード 3

  1. 気管支鏡

  2. 画像支援システム

  3. 予測モデル

研究分野 2

  1. ライフサイエンス / 腫瘍診断、治療学

  2. ライフサイエンス / 呼吸器内科学

現在の研究課題とSDGs 2

  1. 間質性肺炎合併末梢肺病変に対する診断的気管支鏡

  2. 気管支鏡診断予測モデル

委員歴 2

  1. 日本呼吸器内視鏡学会   中部支部評議員  

    2023年4月 - 2025年3月   

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    団体区分:学協会

  2. 日本呼吸器内視鏡学会   気管支鏡チーム医療推進ワーキンググループ  

    2023年 - 2025年6月   

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    団体区分:学協会

受賞 1

  1. 2023年度日本呼吸器内視鏡学会奨励賞

    2023年   日本呼吸器内視鏡学会   EBUS-GS法を用いた間質性肺病変合併末梢肺野病変において線維性変化との位置関係から着目した検討

    伊藤 貴康

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    受賞区分:国内学会・会議・シンポジウム等の賞  受賞国:日本国

 

論文 22

  1. Prevention of droplet dispersal with 'e-mask': A new daily use endoscopic mask during bronchoscopy 査読有り

    Ito T, Okachi S, Sato K, Yasui H, Fukatsu N, Ando M, Chen-Yoshikawa TF, Saka H.

    Respirology     2022年7月

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    担当区分:筆頭著者   記述言語:英語  

    DOI: https://doi.org/10.1111/resp.14321

  2. A Diagnostic Predictive Model of Bronchoscopy with Radial Endobronchial Ultrasound for Peripheral Pulmonary Lesions 査読有り

    Ito, T; Matsumoto, Y; Okachi, S; Nishida, K; Tanaka, M; Imabayashi, T; Tsuchida, T; Hashimoto, N

    RESPIRATION   101 巻 ( 12 ) 頁: 1148 - 1156   2022年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Respiration  

    Background: Several factors have been reported to affect the diagnostic yield of bronchoscopy with radial endobronchial ultrasound (R-EBUS) for peripheral pulmonary lesions (PPLs). However, it is difficult to accurately predict the diagnostic potential of bronchoscopy for each PPL in advance. Objectives: Our objective was to establish a predictive model to evaluate the diagnostic yield before the procedure. Method: We retrospectively analysed consecutive patients who underwent diagnostic bronchoscopy with R-EBUS between April 2012 and October 2015. We assessed the factors that were predictive of successful bronchoscopic diagnosis of PPLs with R-EBUS using a multivariable logistic regression model. The accuracy of the predictive model was evaluated using the receiver operator characteristic area under the curve (ROC AUC). Internal validation was analysed using 10-fold stratified cross-validation. Results: We analysed a total of 1,634 lesions; the median lesion size was 25.0 mm. Of these, 1,138 lesions (69.6%) were successfully diagnosed. In the predictive logistic model, significant factors affecting the diagnostic yield were lesion size, lesion structure, bronchus sign, and visible on chest X-ray. The predictive model consisted of seven factors: lesion size, lesion lobe, lesion location from the hilum, lesion structure, bronchus sign, visibility on chest X-ray, and background lung. The ROC AUC of the predictive model was 0.742 (95% confidence interval: 0.715-0.769). Internal validation using 10-fold stratified cross-validation revealed a mean ROC AUC of 0.734. Conclusions: The predictive model using the seven factors revealed a good performance in estimating the diagnostic yield.

    DOI: 10.1159/000526574

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  3. Endobronchial Ultrasonography with a Guide Sheath Transbronchial Biopsy for Diagnosing Peripheral Pulmonary Lesions within or near Fibrotic Lesions in Patients with Interstitial Lung Disease 査読有り

    Ito T, Okachi S, Kimura T, Kataoka K, Suzuki Y, Kinoshita F, Wakahara K, Hashimoto N, Kondoh Y

    Cancers(Basel)     2021年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: https://doi.org/10.3390/cancers13225751

  4. A Pilot Study of Transbronchial Biopsy Using Endobronchial Ultrasonography with a Guide Sheath in the Diagnosis of Peripheral Pulmonary Lesions in Patients with Interstitial Lung Disease 査読有り

    Ito T, Kimura T, Kataoka K, Okachi S, Wakahara K, Hashimoto N, Kondoh Y

    Diagnostics (Basel)     2021年

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    担当区分:筆頭著者   記述言語:英語  

    DOI: https://doi.org/10.3390/diagnostics11122269

  5. The Value of Additional Conventional Transbronchial Biopsy in the Negative Results of Rapid On-site Evaluation During Endobronchial Ultrasound With Guide Sheath to Diagnose Small Peripheral Lung Cancer 査読有り

    Ito T, Okachi S, Ikenouchi T, Ushijima F, Ohashi T, Ogawa M, Nagahama M, Hashimoto N

    Technol Cancer Res Treat     2021年

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    担当区分:筆頭著者   記述言語:英語  

    DOI: https://doi.org/10.1177/15330338211043040

  6. Real-time ultrasound-guided thoracentesis simulation using an optical see-through head-mounted display: A proof-of-concept study

    Okachi S., Matsui T., Sakurai M., Ito T., Morise M., Imaizumi K., Ishii M., Fujiwara M.

    Journal of Ultrasonography   24 巻 ( 96 ) 頁: 20240012   2024年2月

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    記述言語:英語   出版者・発行元:Journal of Ultrasonography  

    Aim: This study aimed to examine the feasibility and potential benefits of an optical see-through head-mounted display (OST-HMD) during real-time ultrasound-guided thoracentesis simulations. Material and methods: Six physicians performed a thoracentesis simulation using an OST-HMD and a wireless image transmission system. The time required, puncture needle visibility, pleural fluid collection success rate, and head movement during the procedure using a smart glass equipped with an inertial measurement unit were all recorded and compared with and without the HMD. Results: Study participants successfully extracted effusions in all procedures. The use of OST-HMD did not significantly affect the time of the procedure, but notably decreased the horizontal and vertical head movements during the procedure. Conclusions: The study demonstrated the feasibility of using an OST-HMD in a simulated real-time ultrasound-guided thoracentesis procedure and showed the potential of HMD in thoracentesis to improve ergonomics and accuracy. Further research is necessary to confirm these findings.

    DOI: 10.15557/jou.2024.0012

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  7. The Application of Mixed Reality in Bronchoscopy Simulation Training: A Feasibility Study

    Okachi, S; Sakurai, M; Matsui, T; Ito, T; Matsuzawa, R; Morise, M; Wakahara, K; Ishii, M; Fujiwara, M

    SURGICAL INNOVATION   30 巻 ( 5 ) 頁: 685 - 686   2023年10月

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    記述言語:英語   出版者・発行元:Surgical Innovation  

    DOI: 10.1177/15533506231160201

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  8. 縦隔リンパ節腫大を呈するラテックスアレルギー患者に対して バルーン非使用下に EBUS-TBNA を施行し確定診断が得られた 2 例 査読有り

    松澤 令子, 伊藤 貴康, 今泉 和良, 石井 あずさ, 伊藤 克樹, 二村 圭祐, 岡地 祥太郎, 森瀬 昌宏, 若原 恵子, 石井 誠

    気管支学   45 巻 ( 5 ) 頁: 339 - 344   2023年

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: https://doi.org/10.18907/jjsre.45.5_339

  9. EBUS-GS TBBに加えてPeriView FLEXを用いたGS-TBNAが肺放線菌症の診断に有用であった1例 査読有り

    篠原 由佳, 伊藤 貴康, 岡地 祥太郎, 下山 芳江, 福谷 衣里子, 松澤 令子, 森瀬 昌宏, 若原 恵子, 石井 誠

    気管支学   45 巻 ( 1 ) 頁: 37 - 42   2023年

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: https://doi.org/10.18907/jjsre.45.1_37

  10. Virtual Bronchoscopy-Guided Transbronchial Biopsy Simulation Using a Head-Mounted Display: A New Style of Flexible Bronchoscopy

    Okachi, S; Ito, T; Sato, K; Iwano, S; Shinohara, Y; Itoigawa, H; Hashimoto, N

    SURGICAL INNOVATION   29 巻 ( 6 ) 頁: 811 - 813   2022年12月

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    出版者・発行元:Surgical Innovation  

    Background/need. The increases in reference images and information during bronchoscopy using virtual bronchoscopic navigation (VBN) and fluoroscopy has potentially created the need for support using a head-mounted display (HMD) because bronchoscopists feel difficulty to see displays that are at a distance from them and turn their head and body in various directions. Methodology and device description. The binocular see-through Moverio BT-35E Smart Glasses can be connected via a high-definition multimedia interface and have a 720p high-definition display. We developed a system that converts fluoroscopic (live and reference), VBN, and bronchoscopic image signals through a converter and references them using the Moverio BT-35E. Preliminary results. We performed a virtual bronchoscopy-guided transbronchial biopsy simulation using the system. Four experienced pulmonologists performed a simulated bronchoscopy of 5 cases each with the Moverio BT-35E glasses, using bronchoscopy training model. For all procedures, the bronchoscope was advanced successfully into the target bronchus according to the VBN image. None of the operators reported eye or body fatigue during or after the procedure. Current status. This small-scale simulation study suggests the feasibility of using a HMD during bronchoscopy. For clinical use, it is necessary to evaluate the safety and usefulness of the system in larger clinical trials in the future.

    DOI: 10.1177/15533506211068928

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  11. Diagnostic value and safety of endobronchial ultrasonography with a guide sheath transbronchial biopsy for diagnosing peripheral pulmonary lesions in patients with interstitial lung disease 査読有り

    Ito, T; Okachi, S; Iwano, S; Kinoshita, F; Wakahara, K; Hashimoto, N; Chen-Yoshikawa, TF

    JOURNAL OF THORACIC DISEASE   14 巻 ( 11 ) 頁: 4361 - 4371   2022年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Thoracic Disease  

    Background: Radial endobronchial ultrasonography transbronchial biopsy with and without a guide sheath is a useful method for diagnosing peripheral pulmonary lesions (PPLs). However, the diagnostic yield and complications of radial endobronchial ultrasonography transbronchial biopsy for PPLs remains elusive in patients with interstitial lung disease (ILD). Methods: We retrospectively analysed 431 patients (69 with and 362 without ILD) who underwent radial endobronchial ultrasonography with a guide sheath transbronchial biopsy (EBUS-GS TBB) for PPLs from April 1, 2011, to March 31, 2020. We investigated the diagnostic yield and complications of the procedure for PPLs and compared them between patients with and without ILD. We also evaluated the factors contributing to successful diagnosis. Results: The diagnostic yield of radial endobronchial ultrasonography in patients with ILD was significantly lower than in those without ILD (62.3% vs. 75.4%, P=0.024). Multivariate analysis showed that the presence of ILD as background lung [odds ratio (OR) =0.517], probe position within the lesion (OR =4.654), and the presence of solid lesion (OR =1.946) significantly affected the diagnostic yield of PPLs. There was a significant difference in the rate of pneumothorax between the patients with ILD and those without ILD (4.3% vs. 0.6%, P=0.031). Conclusions: The presence of ILD as the background lung significantly affected the diagnostic yield of PPLs with radial EBUS-GS TBB. Regarding the complications, pneumothorax occurred more frequently in patients with ILD than in those without ILD.

    DOI: 10.21037/jtd-22-809

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  12. Prevention of droplet dispersal with 'e-mask': A new daily use endoscopic mask during bronchoscopy

    Ito, T; Okachi, S; Sato, K; Yasui, H; Fukatsu, N; Ando, M; Chen-Yoshikawa, TF; Saka, H

    RESPIROLOGY   27 巻 ( 10 ) 頁: 863 - 873   2022年10月

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    記述言語:英語   出版者・発行元:Respirology  

    Background and objective: Bronchoscopy is an airborne particle-generating procedure. However, few methods for safe bronchoscopy have been developed. To reduce airborne particles during bronchoscopy, we created an ‘e-mask’, which is a simple, disposable mask for patients. Our objective was to evaluate the e-mask's protective ability against airborne particles and to assess respiratory adverse events and complications. Methods: Patients with stage 2–4 chronic obstructive pulmonary disease were excluded. We performed visualization and quantifying experiments on airborne particles with and without the e-mask. We prospectively evaluated whether wearing the e-mask during bronchoscopy was associated with the incidence of patients requiring >5 L/min oxygen to maintain >90% oxygen saturation, and patients with >45 mm Hg end-tidal carbon dioxide (EtCO2) elevation, in addition to complications, compared to historical controls. Results: In the visualization experiment, more than ten thousand times of airborne particles were generated without the e-mask than with the e-mask. The volume of airborne particles was significantly reduced with the e-mask, compared to that without the e-mask (p = 0.011). Multivariate logistic regression analysis revealed that wearing the e-mask had no significant effect on the incidence of patients requiring >5 L/min oxygen to maintain >90% oxygen saturation, (p = 0.959); however, wearing the e-mask was a significant factor in >45 mm Hg EtCO2 elevation (p = 0.026). No significant differences in complications were observed between the e-mask and control groups (5.8% vs. 2.5%, p = 0.395). Conclusion: Wearing the e-mask during bronchoscopy significantly reduced the generation of airborne particles during bronchoscopy without increasing complications.

    DOI: 10.1111/resp.14321

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  13. Epidermal growth factor receptor mutation-positive advanced lung adenocarcinoma presenting with acute respiratory failure diagnosed by thin bronchoscope through transnasal route under high-concentration oxygen mask

    Ito, T; Makino, Y; Mashimo, S; Baba, T; Otsuki, R; Yasui, H; Fukui, Y; Odate, M; Arai, Y; Okachi, S; Wakahara, K; Hashimoto, N

    RESPIROLOGY CASE REPORTS   10 巻 ( 9 ) 頁: e01007   2022年9月

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    記述言語:英語   出版者・発行元:Respirology Case Reports  

    A 59-year-old woman complained of continuous dyspnea. Computed tomography revealed multiple pulmonary nodules, mildly small enlarged mediastinal lymph nodes and a nodule in the liver segment 8. Her dyspnea worsened with respiratory failure 4 days after presentation. Liver biopsy was not possible as she could not hold her breath; thus, we performed bronchoscopy. For biopsy, the pulmonary nodules with a positive bronchus sign were preferred over the mildly small enlarged mediastinal lymph nodes. Bronchoscopy under non-invasive positive pressure ventilation (NPPV) or high-flow nasal cannula (HFNC) was impossible because of the lack of equipment. Therefore, we biopsied via thin bronchoscope through nasal cavity under a high-concentration oxygen mask. Pathological findings revealed epidermal growth factor receptor mutation-positive lung adenocarcinoma. For patients with respiratory failure who cannot undergo bronchoscopy under NPPV or HFNC, thin bronchoscopy through the nasal cavity under a high-concentration oxygen mask may be clinically useful to prevent hypoxaemia during the procedure.

    DOI: 10.1002/rcr2.1007

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  14. Oropharyngeal suctioning and nasogastric tube insertion with a new mask for reduction of droplet dispersion: a proposal for a new preventive strategy during the coronavirus disease pandemic

    Okachi, S; Ito, T; Yasui, H; Fukatsu, N; Sato, K

    JOURNAL OF HOSPITAL INFECTION   123 巻   頁: 12 - 14   2022年5月

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    記述言語:英語   出版者・発行元:Journal of Hospital Infection  

    DOI: 10.1016/j.jhin.2022.01.022

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  15. Efficacy of endobronchial ultrasound-guided transbronchial biopsy without guide sheath for small peripheral pulmonary lesions (≤15 mm): A retrospective cohort study 査読有り

    Ito T, Matsumoto M, Kujime M, Kohnoh T, Fukushima A, Takagi T, Fukushima Y, Kasahara T

    Clin Respir J     2021年6月

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    担当区分:筆頭著者   記述言語:英語  

    DOI: https://doi.org/10.1111/crj.13324

  16. Unusual presentation of recurrent follicular lymphoma as diffuse granular shadow 査読有り

    Ito T, Okachi S, Ishikawa Y, Shimada S, Wakahara K, Hashimoto N

    Respirol Case Rep     2021年2月

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    担当区分:筆頭著者   記述言語:英語  

    DOI: https://doi.org/10.1002/rcr2.710

  17. Epidermal growth factor receptor mutation-positive advanced lung adenocarcinoma presenting with acute respiratory failure diagnosed by thin bronchoscope through transnasal route under high-concentration oxygen mask 査読有り

    Ito T, Makino Y, Mashimo S, Baba T, Otsuki R, Yasui H, Fukui Y, Odate M, Arai Y, Okachi S, Wakahara K, Hashimoto N.

    Respirol Case Rep   10 巻 ( 9 )   2020年8月

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    担当区分:筆頭著者   記述言語:英語  

    DOI: 10.1002/rcr2.1007.

  18. Endobronchial ultrasound-guided transbronchial needle aspiration under non-invasive positive pressure for the diagnosis of lung metastasis due to renal cell carcinoma in a patient with respiratory failure 査読有り

    Ito T, Okachi S, Ikenouchi T, Ushijima F, Ohashi T, Ogawa M, Nagahama M, Wakahara K, Hashimoto N

    Respir Med Case Rep     2020年2月

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    記述言語:英語  

    DOI: https://doi.org/10.1016/j.rmcr.2020.101028

  19. Endobronchial Mucosa-associated Lymphatic Tissue Lymphoma Diagnosed Using the Hot Biopsy Forceps Technique 査読有り

    Ito T, Ikenouchi T, Ogawa M, Ohashi T

    J Jpn Soc Respir Endoscopy     2020年

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    担当区分:筆頭著者   記述言語:英語  

  20. Prognostic Impact and Risk Factors of Immune-Related Pneumonitis in Patients With Non-Small-Cell Lung Cancer Who Received Programmed Death 1 Inhibitors 査読有り

    Fukihara J, Sakamoto K, Koyama J, Ito T, Iwano S, Morise M, Ogawa M, Kondoh Y, Kimura T, Hashimoto N, Hasegawa Y

    Clin Lung Cancer     2019年11月

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    記述言語:英語  

    DOI: https://doi.org/10.1016/j.cllc.2019.07.006

  21. Respiratory failure patient with lung cancer diagnosed by transesophageal bronchoscopic ultrasound-guided aspirates 査読有り

    Ito T, Oki M, Saka H, Kondoh Y, Kimura T, Kataoka K

    Respirol Case Rep     2018年2月

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    担当区分:筆頭著者   記述言語:英語  

    DOI: https://doi.org/10.1002/rcr2.309

  22. 難治性気胸に対して局所麻酔下胸腔鏡を用いたフィブリン糊散布とPGAシートが有用であった1例 査読有り

    伊藤 貴康, 宇佐美 範恭, 伊藤 克樹, 水野 秀和, 堀尾 美穂子, 齋藤 裕子

    気管支学     2016年

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    担当区分:筆頭著者   記述言語:日本語  

▼全件表示

共同研究・競争的資金等の研究課題 2

  1. 間質性肺炎合併末梢肺病変に対する診断率向上を目指した経気管支穿刺吸引針生検追加手技の診断能と安全性に関する単施設無作為化比較試験

    2023年4月 - 2024年3月

    内視鏡医学研究振興財団 

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    担当区分:研究代表者  資金種別:競争的資金

  2. 末梢肺病変に対するガイドシース併用針生検を活用した新たな検体採取法の確立

    日本呼吸器内視鏡学会呼吸器内視鏡研究助成 

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    担当区分:研究代表者  資金種別:競争的資金

科研費 1

  1. 間質性肺炎合併早期肺癌への経気管支凍結療法を用いた新規内視鏡治療の基礎的検討

    研究課題/研究課題番号:24K19106  2024年4月 - 2026年3月

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    担当区分:研究代表者