2023/09/25 更新

写真a

ミヤギ　ショウヘイ
宮城　尚平
MIYAGI Shohei
所属
医学部附属病院 病理部 助教
職名
助教

学位 2

  1. 博士（医学） （ 2022年3月   名古屋大学 ） 

  2. 学士（医学） （ 2016年3月   名古屋大学 ） 

学位の先頭へ▲
 

論文 4

  1. Comprehensive Analyses of Intraviral Epstein-Barr Virus Protein-Protein Interactions Hint Central Role of BLRF2 in the Tegument Network 査読有り

    Hara Yuya, Watanabe Takahiro, Yoshida Masahiro, Al Masud H. M. Abdullah, Kato Hiromichi, Kondo Tomohiro, Suzuki Reiji, Kurose Shutaro, Uddin Md Kamal, Arata Masataka, Miyagi Shouhei, Yanagi Yusuke, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

    JOURNAL OF VIROLOGY   96 巻 ( 14 ) 頁： e0051822   2022年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Journal of Virology  

    Protein-protein interactions (PPIs) are crucial for various biological processes. Epstein-Barr virus (EBV) proteins typically form complexes, regulating the replication and persistence of the viral genome in human cells. However, the role of EBV protein complexes under physiological conditions remains unclear. In this study, we performed comprehensive analyses of EBV PPIs in living cells using the NanoBiT system. We identified 195 PPIs, many of which have not previously been reported. Computational analyses of these PPIs revealed that BLRF2, which is only found in gammaherpesviruses, is a central protein in the structural network of EBV tegument proteins. To characterize the role of BLRF2, we generated two BLRF2 knockout EBV clones using CRISPR/Cas9. BLRF2 knockout significantly decreased the production of infectious virus particles, which was partially restored by exogenous BLRF2 expression. In addition, self-association of BLRF2 protein was found, and mutation of the residues crucial for the self-association affected stability of the protein. Our data imply that BLRF2 is a tegument network hub that plays important roles in progeny virion maturation.

    DOI： 10.1128/jvi.00518-22

    Web of Science

    Scopus

    PubMed

  2. A STING inhibitor suppresses EBV-induced B cell transformation and lymphomagenesis 査読有り

    Miyagi Shouhei, Watanabe Takahiro, Hara Yuya, Arata Masataka, Uddin Md. Kamal, Mantoku Keisuke, Sago Ken, Yanagi Yusuke, Suzuki Takeshi, Masud H. M. Abdullah Al, Kawada Jun-ichi, Nakamura Shigeo, Miyake Yasuyuki, Sato Yoshitaka, Murata Takayuki, Kimura Hiroshi

    CANCER SCIENCE     2021年10月

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    担当区分：筆頭著者   記述言語：英語   掲載種別：学位論文（博士）  

  3. Expression of programmed cell death ligand-1 by immune cells in the microenvironment is a favorable prognostic factor for primary diffuse large B-cell lymphoma of the central nervous system 査読有り

    Tsuyuki Yuta, Ishikawa Eri, Kohno Kei, Shimada Kazuyuki, Ohka Fumiharu, Suzuki Yuka, Mabuchi Seiyo, Satou Akira, Takahara Taishi, Kato Seiichi, Miyagi Shohei, Ozawa Hiroyuki, Kawano Tasuku, Takagi Yusuke, Hiraga Junji, Wakabayashi Toshihiko, Nakamura Shigeo

    NEUROPATHOLOGY   41 巻 ( 2 ) 頁： 99 - 108   2021年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  4. Reappraisal of Primary Epstein-Barr Virus (EBV)-positive Diffuse Large B-Cell Lymphoma of the Gastrointestinal Tract Comparative Analysis Among Immunosuppressed and Nonimmunosuppressed Stage I and II-IV Patients 査読有り

    Miyagi Shouhei, Ishikawa Eri, Nakamura Masanao, Shimada Kazuyuki, Yamamura Takeshi, Furukawa Kazuhiro, Tanaka Tsutomu, Mabuchi Seiyo, Tsuyuki Yuta, Kohno Kei, Sakakibara Ayako, Satou Akira, Kato Seiichi, Fujishiro Mitsuhiro, Nakamura Shigeo

    AMERICAN JOURNAL OF SURGICAL PATHOLOGY   44 巻 ( 9 ) 頁： 1173 - 1183   2020年9月

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

論文の先頭へ▲