Updated on 2023/03/28


Graduate School of Medicine Designated assistant professor
Designated assistant professor

Degree 1

  1. 博士(医学) ( 2021.10 ) 

Research Interests 1

  1. 脳血管障害

Research Areas 1

  1. Life Science / Neurosurgery


Papers 5

  1. The usefulness and safety of dexmedetomidine for postoperative sedation in pediatric patients with moyamoya disease

    Kanamori Fumiaki, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Kurimoto Michihiro, Shiba Yoshiki, Mamiya Takashi, Takayanagi Kai, Ishii Kazuki, Nishihori Masahiro, Izumi Takashi, Okamoto Sho, Saito Ryuta

    JOURNAL OF NEUROSURGERY-PEDIATRICS   Vol. 30 ( 3 ) page: 301 - 307   2022.9

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    Publisher:Journal of Neurosurgery: Pediatrics  

    OBJECTIVE After revascularization surgery in pediatric patients with moyamoya disease (MMD), resting and avoiding crying is important. However, this inaction is often difficult because of pain or anxiety. Dexmedetomidine (DEX), which has sedative and analgesic properties, may be useful in reducing those uncomfortable conditions; however, its common side effects include bradycardia and hypotension, which have a risk of decreasing the cerebral blood flow. The aim of this study was to investigate the efficacy and safety of using DEX for pediatric patients with MMD in the acute period after revascularization surgery. METHODS This retrospective study included pediatric patients with MMD who underwent revascularization surgery. Based on whether DEX was used for light sedation during postoperative days (PODs) 0–1 after extubation, the patients were divided into DEX or control groups. For neurological outcomes, the incidence of symptomatic cerebral infarction and transient neurological events (TNEs) during PODs 0–1 and the entire hospitalization were investigated. In addition, the Richmond Agitation-Sedation Scale (RASS) was used to assess the effect of DEX, and bradycardia and hypotension were evaluated as side effects. RESULTS A total of 84 surgical procedures were included in this study (27 in the DEX group and 57 in the control group). During PODs 0–1, symptomatic infarction was not observed in either group. The incidence of TNEs was almost the same in both groups: 2 (7.4%) of the 27 procedures in the DEX group and 4 (7.0%) of the 57 procedures in the control group (p > 0.99). Moreover, the incidences of symptomatic infarction and TNEs during the entire hospitalization did not differ significantly (symptomatic infarction, p > 0.99; TNEs, p = 0.20). Regarding the DEX effect, the median RASS scores during PODs 0–1 were −1.0 (drowsy) in the DEX group and +1.0 (restless) in the control group, showing a significant difference (p < 0.01). Regarding side effects, bradycardia was observed only in 3 (11.1%) of the 27 procedures in the DEX group (p = 0.03), and hypotension was not observed in any of the cases. CONCLUSIONS In pediatric patients with MMD who are extubated after revascularization surgery, DEX produced appropriate light sedation and analgesia. The risk for symptomatic infarction is almost the same in cases in which DEX is used and those in which it is not; however, neurosurgeons should be cautious of bradycardia and TNEs as potential side effects.

    DOI: 10.3171/2022.6.PEDS2241

    Web of Science


  2. Surgical disconnection of a hypoglossal canal dural arteriovenous fistula demonstrating rapid progression of medulla oblongata disturbance: illustrative case.

    Kawasaki Y, Kanamori F, Tsukada T, Shintai K, Takasu S, Seki Y

    Journal of neurosurgery. Case lessons   Vol. 3 ( 6 )   2022.2

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    DOI: 10.3171/CASE21657


  3. Transcriptome-wide analysis of intracranial artery in patients with moyamoya disease showing upregulation of immune response, and downregulation of oxidative phosphorylation and DNA repair Reviewed

    Neurosurg Focus .     2021.9

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  4. Effects of aspirin and heparin treatment on perioperative outcomes in patients with Moyamoya disease Invited Reviewed

    Acta Neurochirurgica (Wein)     2021.5

  5. Prevention of the Rerupture of Collateral Artery Aneurysms on the Ventricular Wall by Early Surgical Revascularization in Moyamoya Disease: Report of Two Cases and Review of the Literature Invited Reviewed

    World Neurosurgery     2018.1

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. 尿中miRNAsを用いた小児もやもや病の診断と病期進行予測

    Grant number:22K16683  2022.4 - 2024.3

    科学研究費助成事業  若手研究

    金森 史哲

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )