Updated on 2022/04/22

写真a

 
MAEDA Kazuyuki
 
Organization
Graduate School of Bioagricultural Sciences Department of Applied Biosciences Assistant Professor
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences Department of Applied Biosciences
Title
Assistant Professor
External link

Degree 1

  1. Doctor (Agriculture) ( 2013.3   Meiji University ) 

Research Areas 2

  1. Environmental Science/Agriculture Science / Plant protection science  / Plant Pathology

  2. Life Science / Applied microbiology

Research History 5

  1. Graduate School of Bioagricultural Sciences, Nagoya University   Department of Applied Biosciences   Assistant Professor

    2022.3

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    Country:Japan

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  2. Meiji University   Organization for the Strategic Coordination of Research and Intellectual Properties   Specially Appointed Associate Professor

    2021.4 - 2022.2

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    Country:Japan

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  3. Meiji University   School of Agriculture Department of Agriculture   Assistant Professor

    2018.4 - 2021.3

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    Country:Japan

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  4. Meiji University   Organization for the Strategic Coordination of Research and Intellectual Properties   Post Doctoral Fellow

    2016.4 - 2018.3

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    Country:Japan

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  5. Nagoya University   Graduate School of Bioagricultural Sciences   Post Doctoral Fellow

    2013.4 - 2016.3

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    Country:Japan

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Education 5

  1. Meiji University   Graduate School of Agriculture

    2009.4 - 2013.3

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  2. 名古屋大学大学院   生命農学研究科   研究アシスタント

    2012.4 - 2013.3

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    Country: Japan

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  3. 理化学研究所   基幹研究所   研修生

    2010.4 - 2012.3

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    Country: Japan

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  4. Meiji University   Graduate School of Agriculture

    2007.4 - 2009.3

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    Country: Japan

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  5. Meiji University   School of Agriculture   Department of Agriculture

    2003.4 - 2007.3

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    Country: Japan

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Professional Memberships 1

  1. 日本農芸化学会

    2010.4

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Awards 1

  1. 学術奨励賞

    2016.7   日本マイコトキシン学会   「トリコテセン生合成経路酵素の進化と毒素生産抑制剤に関する研究」

    前田 一行

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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Papers 39

  1. Accumulation of 4-Deoxy-7-Hydroxytrichothecenes, but Not 4,7-Dihydroxytrichothecenes, in Axenic Culture of a Transgenic Nivalenol Chemotype Expressing the NX-type<i> FgTri1</i> Gene Reviewed

    Kazuyuki Maeda, Yuichi Nakajima, Yoshiaki Koizumi, Naoko Takahashi-Ando, Makoto Kimura, Shuichi Ohsato

    International Journal of Molecular Sciences   Vol. 22 ( 21 )   2021.10

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms222111428

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  2. Isolation of <i>Fusarium asiaticum</i> from creeping bentgrass with blight symptom and its trichothecene chemotype Reviewed

    Kazuyuki Maeda, Masaru Yamashita, Shuichi Ohsato

    JSM Mycotoxins     2021.9

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    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association of Mycotoxicology  

    DOI: 10.2520/myco.72-1-2

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  3. Impact of nitrogen metabolism-associated culture pH changes on regulation of Fusarium trichothecene biosynthesis: revision of roles of polyamine agmatine and transcription factor AreA Reviewed

    Yuichi Nakajima, Manami Akasaka, Takuya Shiobara, Yoshiyuki Kitou, Kazuyuki Maeda, Kyoko Kanamaru, Shuichi Ohsato, Tetsuo Kobayashi, Takumi Nishiuchi, Makoto Kimura

    Current Genetics   Vol. 66 ( 6 ) page: 1179 - 1190   2020.12

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    DOI: 10.1007/s00294-020-01102-x

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    Other Link: http://link.springer.com/article/10.1007/s00294-020-01102-x/fulltext.html

  4. Synthetic liquid media for the study of trichothecene biosynthesis regulation in <i>Fusarium graminearum</i> Reviewed

    Asuka Nakao, Yuichi Nakajima, Manami Akasaka, Yoshiyuki Kitou, Kazuyuki Maeda, Kyoko Kanamaru, Tetsuo Kobayashi, Makoto Kimura

    JSM Mycotoxins   Vol. 70 ( 2 ) page: 57 - 59   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association of Mycotoxicology  

    DOI: 10.2520/myco.70-2-6

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  5. Substrate specificities of Fusarium biosynthetic enzymes explain the genetic basis of a mixed chemotype producing both deoxynivalenol and nivalenol-type trichothecenes Reviewed International journal

    Kazuyuki Maeda, Yuya Tanaka, Momoko Matsuyama, Masayuki Sato, Kazuki Sadamatsu, Tamotsu Suzuki, Kosuke Matsui, Yuichi Nakajima, Takeshi Tokai, Kyoko Kanamaru, Shuichi Ohsato, Tetsuo Kobayashi, Makoto Fujimura, Takumi Nishiuchi, Naoko Takahashi-Ando, Makoto Kimura

    International Journal of Food Microbiology   Vol. 320   page: 108532 - 108532   2020.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    Fusarium species are traditionally grouped into type A and type B trichothecene producers based on structural differences in the mycotoxin they synthesize. The type B trichothecene-producing Fusarium graminearum strains are further divided into 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), and nivalenol (NIV) chemotypes. The former two chemotypes, collectively termed a deoxynivalenol (DON) chemotype, evolved from a NIV chemotype by inactivation of FgTri13, which encodes trichothecene C-4 hydroxylase, during the evolutionary process. Despite stable overexpression of FgTri13, however, both 3-acetylnivalenol (3-ANIV) and 3-ADON accumulate equally in shake flask culture of a transgenic 3-ADON chemotype. In this study, we investigated why the "3-ANIV chemotype" could not be obtained using this strategy. When analysis was extended to the transgenic NIV chemotype, in which FgTri7 C-4 acetylase gene was disrupted and FgTri8 deacetylase gene was replaced with the 3-ADON chemotype's orthologue, C-4 unoxygenated 3-ADON, as well as C-4 oxygenated 3-ANIV, accumulated as the end product. A feeding experiment with an ΔFgtri5ΔFgtri3 double gene disruptant, a trichothecene non-producing mutant unable to acetylate C-15 of the trichothecene ring, revealed the importance of the 15-O-acetyl group for efficient C-4 hydroxylation of DON-type trichothecenes. This implies that traditional DON and NIV chemotype diversification is not solely explained by FgTri13, but is also explained by the function of the FgTri8 trichothecene deacetylase gene. None of the crude cell extracts from existing chemotypes showed highly specific C-15 deacetylation activity against 3,15-diacetylnivalenol (3,15-diANIV) without deacetylating C-15 of the C-4 unoxygenated earlier intermediate, 3,15-diacetyldeoxynivalenol. Thus, an unnatural Fusarium trichothecene, 3-ANIV, could only be synthesized as part of a mixture with 3-ADON, unless the esterase encoded by FgTri8 evolves to act on the 15-O-acetyl of 3,15-diANIV with high specificity. We also explain why the transgenic "15-ANIV chemotype", which can be generated through functional inactivation of FgTri7, uses an engineered pathway via 3,15-diANIV, but not 15-ADON, to generate 15-ANIV. Tri genes appear to evolve continuously, and altered functions of trichothecene pathway enzymes result in the generation of new trichothecenes, such as NX-2 and NX-3, which have been recently discovered in field isolates of F. graminearum. As recombination of FgTri8 between existing F. graminearum isolates could give rise to a strain that produces mixtures of DON and NIV-type trichothecenes, it may also be noteworthy to monitor the emergence of a field isolate that invalidates traditional chemotype classification.

    DOI: 10.1016/j.ijfoodmicro.2020.108532

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  6. Reduced Toxicity of Trichothecenes, Isotrichodermol, and Deoxynivalenol, by Transgenic Expression of the Tri101 3-O-Acetyltransferase Gene in Cultured Mammalian FM3A Cells Reviewed

    Nozomu Tanaka, Ryo Takushima, Akira Tanaka, Ayaki Okada, Kosuke Matsui, Kazuyuki Maeda, Shunichi Aikawa, Makoto Kimura, Naoko Takahashi-Ando

    Toxins   Vol. 11 ( 11 ) page: 654 - 654   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:{MDPI} {AG}  

    <jats:p>In trichothecene-producing fusaria, isotrichodermol (ITDol) is the first intermediate with a trichothecene skeleton. In the biosynthetic pathway of trichothecene, a 3-O-acetyltransferase, encoded by Tri101, acetylates ITDol to a less-toxic intermediate, isotrichodermin (ITD). Although trichothecene resistance has been conferred to microbes and plants transformed with Tri101, there are no reports of resistance in cultured mammalian cells. In this study, we found that a 3-O-acetyl group of trichothecenes is liable to hydrolysis by esterases in fetal bovine serum and FM3A cells. We transfected the cells with Tri101 under the control of the MMTV-LTR promoter and obtained a cell line G3 with the highest level of C-3 acetylase activity. While the wild-type FM3A cells hardly grew in the medium containing 0.40 μM ITDol, many G3 cells survived at this concentration. The IC50 values of ITDol and ITD in G3 cells were 1.0 and 9.6 μM, respectively, which were higher than the values of 0.23 and 3.0 μM in the wild-type FM3A cells. A similar, but more modest, tendency was observed in deoxynivalenol and 3-acetyldeoxynivalenol. Our findings indicate that the expression of Tri101 conferred trichothecene resistance in cultured mammalian cells.</jats:p>

    DOI: 10.3390/toxins11110654

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  7. Identification of amino acids negatively affecting Fusarium trichothecene biosynthesis Reviewed International journal

    Takuya Shiobara, Yuichi Nakajima, Kazuyuki Maeda, Manami Akasaka, Yoshiyuki Kitou, Kyoko Kanamaru, Shuichi Ohsato, Tetsuo Kobayashi, Takumi Nishiuchi, Makoto Kimura

    Antonie van Leeuwenhoek   Vol. 112 ( 3 ) page: 471 - 478   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    Nitrogen sources in media have a significant impact on the onset of secondary metabolism in fungi. For transcriptional activation of many nitrogen catabolic genes, an AreA transcription factor is indispensable. This also holds true for Fusarium graminearum that produces trichothecenes, an important group of mycotoxin, in axenic culture. Despite the presence of numerous consensus AreA-binding sites in the promoters of Tri genes in the trichothecene cluster core region, the effect of medium amino acids on trichothecene biosynthesis is poorly understood. In this study, we examined the effect of certain amino acids, which were predicted to activate AreA function and increase Tri gene transcription, on trichothecene production in liquid culture. By frequent monitoring and adjustments in the pH of the culture medium, including replacement of the spent medium with fresh medium, we demonstrate the suppressive effects of the amino acids, used as the sole nitrogen source, on trichothecene biosynthesis. When the medium pH was maintained at 4.0, Gly, L-Ser, and L-Thr suppressed trichothecene production by F. graminearum. Enhanced trichothecene-inducing effects were observed when the medium pH was 3.5, with only L-Thr suppressing trichothecene synthesis.

    DOI: 10.1007/s10482-018-1172-z

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  8. Comparison of HPLC-UV and LC-MS methods for evaluating the amount of deoxynivalenol-type trichothecenes in axenic solid culture of <i>Fusarium graminearum</i> Reviewed

    Akira Tanaka, Koki Shinkai, Kazuyuki Maeda, Yuichi Nakajima, Shigeru Ishii, Yasuhiko Yoshida, Makoto Kimura, Naoko Takahashi-Ando

    JSM Mycotoxins   Vol. 69 ( 1 ) page: 15 - 17   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association of Mycotoxicology  

    DOI: 10.2520/myco.69-1-2

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  9. Inhibition of Fusarium trichothecene biosynthesis by yeast extract components extractable with ethyl acetate Reviewed

    Yuya Tanaka, Yuichi Nakajima, Kazuyuki Maeda, Momoko Matsuyama, Kyoko Kanamaru, Tetsuo Kobayashi, Shuichi Ohsato, Makoto Kimura

    International Journal of Food Microbiology   Vol. 289   page: 24 - 29   2019.1

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.ijfoodmicro.2018.08.026

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  10. Studies on <i>Fusarium</i> trichothecene biosynthesis: functional characterization of orthologous pathway genes and development of various types of inhibitors

    Kazuyuki Maeda

    JSM Mycotoxins   Vol. 68 ( 2 ) page: 77 - 82   2018.7

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association of Mycotoxicology  

    DOI: 10.2520/myco.68-2-1

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  11. Identification and Characterization of Small Molecule Compounds That Modulate Trichothecene Production by Fusarium graminearum Reviewed

    Kazuyuki Maeda, Hinayo Ichikawa, Yuichi Nakajima, Takayuki Motoyama, Shuichi Ohsato, Kyoko Kanamaru, Tetsuo Kobayashi, Takumi Nishiuchi, Hiroyuki Osada, Makoto Kimura

    ACS Chemical Biology   Vol. 13 ( 5 ) page: 1260 - 1269   2018.5

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    DOI: 10.1021/acschembio.8b00044

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  12. Exploring an Artificial Metabolic Route in Fusarium sporotrichioides: Production and Characterization of 7-Hydroxy T-2 Toxin Reviewed

    Kentaro Kamata, Hiroki Sato, Kazuyuki Maeda, Kazuo Furihata, Shunichi Aikawa, Kentaro Adachi, Akira Tanaka, Takeshi Tokai, Yuichi Nakajima, Yasuhiko Yoshida, Shohei Sakuda, Makoto Kimura, Naoko Takahashi-Ando

    Journal of Natural Products   Vol. 81 ( 4 ) page: 1041 - 1044   2018.4

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    © 2018 American Chemical Society and American Society of Pharmacognosy. An artificial metabolic route to an unnatural trichothecene was designed by taking advantage of the broad substrate specificities of the T-2 toxin biosynthetic enzymes of Fusarium sporotrichioides. By feeding 7-hydroxyisotrichodermin, a shunt pathway metabolite of F. graminearum, to a trichodiene synthase-deficient mutant of F. sporotrichioides, 7-hydroxy T-2 toxin (1) was obtained as the final metabolite. Such an approach may have future applications in the metabolic engineering of a variety of fungal secondary metabolites. The toxicity of 7-hydroxy T-2 toxin was 10 times lower than that of T-2 toxin in HL-60 cells.

    DOI: 10.1021/acs.jnatprod.7b00398

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  13. Increased metabolite production by deletion of an HDA1-type histone deacetylase in the phytopathogenic fungi, Magnaporthe oryzae (Pyricularia oryzae ) and Fusarium asiaticum Reviewed

    K. Maeda, M. Izawa, Y. Nakajima, Q. Jin, T. Hirose, T. Nakamura, H. Koshino, K. Kanamaru, S. Ohsato, T. Kamakura, T. Kobayashi, M. Yoshida, M. Kimura

    Letters in Applied Microbiology   Vol. 65 ( 5 ) page: 446 - 452   2017.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1111/lam.12797

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  14. l-Threonine and its analogue added to autoclaved solid medium suppress trichothecene production by Fusarium graminearum Reviewed

    Kazuyuki Maeda, Yuichi Nakajima, Yoshikazu Tanahashi, Yoshiyuki Kitou, Akihiro Miwa, Kyoko Kanamaru, Tetsuo Kobayashi, Takumi Nishiuchi, Makoto Kimura

    Archives of Microbiology   Vol. 199 ( 6 ) page: 945 - 952   2017.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    DOI: 10.1007/s00203-017-1364-3

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  15. Identification of a trichothecene production inhibitor by chemical array and library screening using trichodiene synthase as a target protein Reviewed

    Kazuyuki Maeda, Yuichi Nakajima, Takayuki Motoyama, Yasumitsu Kondoh, Tatsuro Kawamura, Kyoko Kanamaru, Shuichi Ohsato, Takumi Nishiuchi, Minoru Yoshida, Hiroyuki Osada, Tetsuo Kobayashi, Makoto Kimura

    Pesticide Biochemistry and Physiology   Vol. 138   page: 1 - 7   2017.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.pestbp.2017.03.006

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  16. Molecular genetic characterization of <i>Fusarium graminearum</i> genes identified as encoding a precocene II-binding protein Reviewed

    Kazuyuki Maeda, Shuichi Ohsato

    JSM Mycotoxins   Vol. 67 ( 1 ) page: 1 - 3   2017

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association of Mycotoxicology  

    DOI: 10.2520/myco.67-1-3

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  17. Accumulation of an unusual trichothecene shunt metabolite in liquid culture of <i>Fusarium graminearum</i> with methionine as the sole nitrogen source Reviewed

    Yuichi Nakajima, Yuya Tanaka, Kosuke Matsui, Kazuyuki Maeda, Yoshiyuki Kitou, Kyoko Kanamaru, Shuichi Ohsato, Tetsuo Kobayashi, Naoko Takahashi-Ando, Makoto Kimura

    JSM Mycotoxins   Vol. 67 ( 1 ) page: 7 - 9   2017

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association of Mycotoxicology  

    DOI: 10.2520/myco.67-1-9

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  18. Oligosaccharides containing an α-(1→2) (glucosyl/xylosyl)-fructosyl linkage as inducer molecules of trichothecene biosynthesis for Fusarium graminearum. Reviewed

    Nakajima Y, Maeda K, Jin Q, Takahashi-Ando N, Kanamaru K, Kobayashi T, Kimura M

    International Journal of Food Microbiology     2016.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijfoodmicro.2016.09.011

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  19. Hydroxylations of trichothecene rings in the biosynthesis of Fusarium trichothecenes: evolution of alternative pathways in the nivalenol chemotype. Reviewed

    Maeda K, Tanaka A, Sugiura R, Koshino H, Tokai T, Sato M, Nakajima Y, Tanahashi Y, Kanamaru K, Kobayashi T, Nishiuchi T, Fujimura M, Takahashi-Ando N, Kimura M

    Environmental Microbiology     2016.11

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1462-2920.13338

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  20. Characterization of the acivicin effects on trichothecene production by Fusarium graminearum species complex. Reviewed

    Maeda K, Nakajima Y, Tanahashi Y, Kosaki T, Kitou Y, Kanamaru K, Kobayashi T, Nishiuchi T, Kimura M

    The Jouranal of General and Applied Microbiology     2016.11

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  21. Trichothecene production in axenic liquid culture of <i>Fusarium graminearum</i> using xylose as a carbon source Reviewed

    Yoshiyuki Kitou, Takahiro Kosaki, Kazuyuki Maeda, Yoshikazu Tanahashi, Yuichi Nakajima, Kyoko Kanamaru, Tetsuo Kobayashi, Makoto Kimura

    JSM Mycotoxins   Vol. 66 ( 1 ) page: 17 - 19   2016

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association of Mycotoxicology  

    DOI: 10.2520/myco.66.17

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  22. Re-examination of genetic and nutritional factors related to trichothecene biosynthesis in Fusarium graminearum. Reviewed

    Kitou Y, Nakajima Y, Maeda K, Jin Q, Nishiuchi T, Kanamaru K, Kobayashi T, Kimura M

    Bioscience, Biotechnology, and Biochemistry     2016

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/09168451.2015.1088374

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  23. Nuclear localization and relative stability of the zinc finger domain of TRI6 trichothecene regulator Reviewed

    Yuichi Nakajima, Kazuyuki Maeda, Shuichi Ohsato, Kyoko Kanamaru, Tetsuo Kobayashi, Makoto Kimura

    JSM Mycotoxins   Vol. 66 ( 1 ) page: 13 - 15   2016

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association of Mycotoxicology  

    DOI: 10.2520/myco.66.13

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  24. Introduction of a leptomycin-sensitive mutation into <i>Fusarium graminearum</i> Reviewed

    Yuichi Nakajima, Kazuyuki Maeda, Shuichi Ohsato, Kyoko Kanamaru, Tetsuo Kobayashi, Makoto Kimura

    JSM Mycotoxins   Vol. 66 ( 1 ) page: 9 - 11   2016

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    DOI: 10.2520/myco.66.9

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  25. Acetyltransferase activity in <i>Pseudomonas</i> sp. capable of acetylating the C-4 hydroxyl group of nivalenol-type trichothecenes Reviewed

    Akira Tanaka, Shohei Saikawa, Takuro Suzuki, Akinobu Echigo, Kazuyuki Maeda, Masayuki Sato, Makoto Fujimura, Takeshi Tokai, Ron Usami, Yasuhiko Yoshida, Makoto Kimura, Naoko Takahashi-Ando

    The Journal of General and Applied Microbiology   Vol. 62 ( 6 ) page: 326 - 329   2016

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Microbiology Research Foundation  

    DOI: 10.2323/jgam.2016.05.002

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  26. 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA) inhibits trichothecene production by Fusarium graminearum through suppression of Tri6 expression. Reviewed

    Etzerodt T, Maeda K, Nakajima Y, Laursen B, Fomsgaard IS, Kimura M

    International Journal of Food Microbiology     2015.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijfoodmicro.2015.07.014

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  27. Evaluation of toxicities of 7-hydroxyisotrichodermin and 8-hydroxyisotrichodermin, shunt intermediates in the biosynthetic grid of deoxynivalenol, by using a sensitive yeast assay Reviewed

    Kentaro Kamata, Akira Tanaka, Kazuyuki Maeda, Ryo Takushima, Hiroki Sato, Shunichi Aikawa, Yasuhiko Yoshida, Makoto Kimura, Naoko Takahashi-Ando

    JSM Mycotoxins   Vol. 65 ( 1 ) page: 7 - 9   2015

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association of Mycotoxicology  

    DOI: 10.2520/myco.65.7

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  28. Effect of disrupting the trichothecene efflux pump encoded by FgTri12 in the nivalenol chemotype of Fusarium graminearum. Reviewed

    Nakajima Y, Koseki N, Sugiura R, Tominaga N, Maeda K, Tokai T, Izawa M, Kanamaru K, Kamakura T, Kobayashi T, Nishiuchi T, Yoshida M, Kimura M

    The Journal of General and Applied Microbiology     2015

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2323/jgam.61.93

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  29. Effects of acivicin on growth, mycotoxin production and virulence of phytopathogenic fungi Reviewed

    K. Maeda, Y. Nakajima, T. Motoyama, Y. Kitou, T. Kosaki, T. Saito, T. Nishiuchi, K. Kanamaru, H. Osada, T. Kobayashi, M. Kimura

    Letters in Applied Microbiology   Vol. 59 ( 4 ) page: 377 - 383   2014.6

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Wiley-Blackwell  

    DOI: 10.1111/lam.12289

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  30. Basic research of the regulation mechanisms of trichothecene production for reduction of the mycotoxin contamination

    Kazuyuki MAEDA, Yuichi NAKAJIMA, Hinayo ICHIKAWA, Yoshiyuki KITOU, Takahiro KOSAKI, Tamio SAITO, Takayuki MOTOYAMA, Hiroyuki OSADA, Tetsuo KOBAYASHI, Makoto KIMURA

      Vol. 64 ( 1 ) page: 69 - 74   2014

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (conference, symposium, etc.)  

    DOI: 10.2520/myco.64.69

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  31. The effect of chemicals on somatic homologous recombination in the rice blast fungus: its possible application for detection of mycotoxins Reviewed

    Takayuki ARAZOE, Shuichi OHSATO, Kazuyuki MAEDA, Tsutomu ARIE, Shigeru KUWATA

    JSM Mycotoxins   Vol. 64 ( 2 ) page: 141 - 146   2014

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association of Mycotoxicology  

    DOI: 10.2520/myco.64.141

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  32. A set of heterologous promoters useful for investigating gene functions in Fusarium graminearum Reviewed

    Yuichi NAKAJIMA, Takeshi TOKAI, Kazuyuki MAEDA, Akira TANAKA, Naoko TAKAHASHI-ANDO, Kyoko KANAMARU, Tetsuo KOBAYASHI, Makoto KIMURA

    JSM Mycotoxins   Vol. 64 ( 2 ) page: 147 - 152   2014

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association of Mycotoxicology  

    DOI: 10.2520/myco.64.147

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  33. Genome engineering of Fusarium species by using positive and negative selection approaches for studying regulation of mycotoxin production

    Yuichi NAKAJIMA, Hinayo ICHIKAWA, Kazuyuki MAEDA, Takumi NISHIUCHI, Tetsuo KOBAYASHI, Makoto KIMURA

      Vol. 63 ( 1 ) page: 85 - 92   2013

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.2520/myco.63.85

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  34. The secreted antifungal protein thionin 2.4 in Arabidopsis thaliana suppresses the toxicity of a fungal fruit body lectin from Fusarium graminearum. Reviewed

    Asano T, Miwa A, Maeda K, Kimura M, Nishiuchi T

    PLoS Pathogens     2013

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.ppat.1003581

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  35. Identification and characterization of an inhibitor of trichothecene 3-O-acetyltransferase, TRI101, by the chemical array approach. Reviewed

    Nakajima Y, Kawamura T, Maeda K, Ichikawa H, Motoyama T, Kondoh Y, Saito T, Kobayashi T, Yoshida M, Osada H, Kimura M

    Bioscience, Biotechnology, and Biochemistry     2013

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1271/bbb.130153

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  36. A promoter of Fusarium graminearum Tri4 does not function when placed at the end of the trichothecene gene cluster Reviewed

    Takeshi TOKAI, Yuichi NAKAJIMA, Hinayo ICHIKAWA, Kazuyuki MAEDA, Takumi NISHIUCHI, Tetsuo KOBAYASHI, Makoto KIMURA

    Mycotoxins   Vol. 63 ( 1 ) page: 17 - 25   2013

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association of Mycotoxicology  

    DOI: 10.2520/myco.63.17

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  37. Production of 3-acetylnivalenol by transgenic Fusarium graminearum expressing Tri13 of type A trichothecene-producer: participation of the encoded cytochrome P450 monooxygenase in type B trichothecene biosynthesis Reviewed

    Kazuyuki MAEDA, Takeshi TOKAI, Hinayo ICHIKAWA, Naoko TAKAHASHI-ANDO, Nobuo OGURA, Katsuyoshi YONEYAMA, Minoru YOSHIDA, Makoto KIMURA

    Mycotoxins   Vol. 62 ( 2 ) page: 83 - 90   2012

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Association of Mycotoxicology  

    DOI: 10.2520/myco.62.83

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  38. Appearance of a new leaf rot disease on common ice plant Reviewed

    Kazuyuki Maeda, Yoshio Kurahashi, Shuichi Ohsato, Katsuyoshi Yoneyama

    Journal of General Plant Pathology   Vol. 76 ( 5 ) page: 303 - 309   2010.7

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    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Springer Nature  

    DOI: 10.1007/s10327-010-0250-5

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  39. In silico restriction landmark genome scanning analysis of Xanthomonas oryzae pathovar oryzae MAFF 311018. Reviewed

    Ichida H, Maeda K, Ichise H, Matsuyama T, Abe T, Yoneyama K, Koba T

    Biochemical and Biophysical Research Communications     2007.11

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2007.09.055

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Research Project for Joint Research, Competitive Funding, etc. 2

  1. 「NX型トリコテセン類の生産に寄与するトリコテセン水酸化酵素TRI1の機能とかび毒生合成に関する研究」

    2019.4 - 2020.3

    平成30年度 学術研究助成  個人研究・登録番号 NO. 19

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    Authorship:Principal investigator  Grant type:Competitive

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  2. 「芝草フザリウム病菌の感染過程の視覚化による感染動態の解析に関する研究」

    2018.4 - 2019.3

    2018年度 芝草研究助成 

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    Authorship:Principal investigator  Grant type:Competitive

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Teaching Experience (Off-campus) 6

  1. 遺伝子工学

    2018.4 - 2021.3 Meiji University)

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  2. 農学基礎実験

    2018.4 - 2021.3 Meiji University)

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  3. 農学実験 III

    2018.4 - 2021.3 Meiji University)

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  4. 農学実験 IV

    2018.4 - 2021.3 Meiji University)

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  5. 分子生物学

    2018.4 - 2021.3 Meiji University)

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  6. 国際農業文化理解(タイ)

    2018.4 - 2018.10 Meiji University)

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