担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Nature Communications  

In nature, plants convert solar energy into chemical energy via water oxidation. Inspired by natural photosynthesis, artificial photosynthesis has been gaining increasing interest in the field of sustainability/green science and technology as a non-natural and thermodynamically endergonic (ΔG° > 0, uphill) solar-energy-driven reaction that uses water as an electron donor and a source material. Among the artificial-photosynthesis processes, inorganic-synthesis reactions via water oxidation, including water splitting and CO2-to-fuel conversion, have been attracting much attention. In contrast, the synthesis of high-value functionalized organic compounds via artificial photosynthesis, which we have termed artificial photosynthesis directed toward organic synthesis (APOS), remains a great challenge. Herein, we report a synthetically pioneering and meaningful strategy of APOS, where the carbohydroxylation of C = C double bonds is accomplished via a three-component coupling with H2 evolution using dual functions of semiconductor photocatalysts, i.e., silver-loaded titanium dioxide (Ag/TiO2) and rhodium–chromium–cobalt-loaded aluminum-doped strontium titanate (RhCrCo/SrTiO3:Al).

DOI： 10.1038/s41467-025-56374-z

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Chemical Communications  

We developed a semiconductor photocatalyst, Pd-Pt alloy nanoparticle-loaded, Al-doped SrTiO3 (PdPt/STO:Al), for photoreduction of unsaturated carboxylic acids. Due to the cooperative STO:Al surface and Pd-Pt alloy nanoparticles, the catalyst dispersed in water provided highly redox-selective photoreduction against oxidative degradation of starting materials/products and against reductive evolution of H2, where minimal glycolic acid worked as an efficient electron-donating fuel.

DOI： 10.1039/d4cc03791j

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Synlett  

In this account, we review our research over the last decade on metal-loaded semiconductor-photocatalyzed organic transformations using alcohols. Different from many reactions using alcohols as mere sacrificial electron donors, our study has demonstrated alcohols as useful organic building blocks incorporated into value-added products. Besides such recollections of previous results, we briefly introduce our ongoing project involving photocatalytic C–C bond-forming reactions via the C–C bond scission of tertiary alcohols. 1 Introduction 2 Dehydroxylative Hydrogenolysis of Allylic Alcohols 3 Acceptorless Dehydrogenation of Activated/Unactivated Alcohols 4 N-Alkylation of Amines using Alcohols as Alkylating Agents 5 Summary and Outlook

DOI： 10.1055/a-2124-4037

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Asian Journal of Organic Chemistry  

Efficient N-methylation is highly required for the synthesis of N-methylated α-amino acids and peptides, both of which are essential motifs in biochemical applications. Herein, we report a photocatalytic system using metal-loaded titanium dioxide in methanol under near-UV light irradiation for N-methylation of α-amino acid or its derivatives at ambient temperature without wasteful stoichiometric reagents. The present method enables the N-methylation of twenty kinds of α-amino acid motifs found in proteins in the human body, whether polar/non-polar or acidic/basic functional groups are embedded in the substrates. Dipeptides also undergo the N-methylation at the N-terminal while the peptide bond and carboxylic acid remain intact. Most of the N-methylated products can be isolated through simple filtration and concentration without tedious purification processes such as an aqueous workup and column chromatography.

DOI： 10.1002/ajoc.202300230

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Coordination Chemistry Reviews  

There is an increasing demand to replace conventional industrial systems that emit massive amounts of CO2 with lower-carbon emitting systems, and this has spurred research on the application of renewable energy for chemical conversions. Hydrogen and other simple chemical products have been efficiently manufactured using renewable light energy or secondary energy sources, such as electricity. More importantly, the direct use of water as a ubiquitous and clean hydrogen (or electron) and oxygen source in organic synthesis has recently been realized. Semiconductor photo- and electrocatalysts, such as metal oxides, play significant roles in energy transformations and in the activation of reactant chemicals. This paper reviews recent developments in organic synthesis using water and renewable light or electric energy to achieve sustainable chemical production. TiO2 is especially featured as a reaction platform where both reactants and water are efficiently activated through coordination with the TiO2 surface. We also discuss the role of water in the reaction on the TiO2 surface from the perspectives of synthetic chemistry, physical surface chemistry, and nanomaterial chemistry.

DOI： 10.1016/j.ccr.2022.214773

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