Updated on 2021/10/04

写真a

 
NATSUME Atsushi
 
Organization
Institutes of Innovation for Future Society Designated professor
Title
Designated professor

Degree 1

  1. Doctor (Medicine) ( 2000.8   Nagoya University ) 

Research Interests 4

  1. 脳神経外科学

  2. 遺伝子解析

  3. 神経再生

  4. 脳腫瘍

Research Areas 1

  1. Others / Others  / Cerebral Neurosurgery

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    1997.4 - 2000.8

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    1989.4 - 1995.3

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    Country: Japan

Professional Memberships 9

  1. 日本脳神経外科学会

  2. 日本脳腫瘍病理学会   評議員

  3. アメリカ神経科学会

  4. アメリカ癌学会

  5. 日本癌学会   評議員

  6. 日本脳神経外科コングレス   運営委員

  7. 日本分子脳神経外科学会   運営委員

  8. 日本遺伝子治療学会   評議員

  9. 日本脳腫瘍学会   理事

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Awards 1

  1. 第12回日本脳神経外科学会奨励賞

    2006.10   日本脳神経外科学会  

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    Country:Japan

 

Papers 102

  1. Next Generation Sequencing-Based Transcriptome Predicts Bevacizumab Efficacy in Combination with Temozolomide in Glioblastoma.

    Adilijiang A, Hirano M, Okuno Y, Aoki K, Ohka F, Maeda S, Tanahashi K, Motomura K, Shimizu H, Yamaguchi J, Wakabayashi T, Natsume A

    Molecules (Basel, Switzerland)   Vol. 24 ( 17 )   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/molecules24173046

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  2. Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-wild-type Diffuse Astrocytic Gliomas.

    Cancer research     2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/0008-5472.CAN-19-1272

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  3. Spontaneous Tumor Regression of Intracranial Solitary Fibrous Tumor Originating From the Medulla Oblongata: A Case Report and Literature Review.

    Yamaguchi J, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Nishikawa T, Shimizu H, Wakabayashi T, Natsume A

    World neurosurgery   Vol. 130   page: 400-404   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2019.07.052

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  4. Posterior Cerebral Artery Reconstruction by In-Situ Bypass with Superior Cerebellar Artery via Occipital Transtentorial Approach

    Tanahashi Kuniaki, Araki Yoshio, Uda Kenji, Muraoka Shinsuke, Motomura Kazuya, Lushun Chalise, Wakabayashi Toshihiko, Natsume Atsushi

    WORLD NEUROSURGERY   Vol. 126   page: 24-29   2019.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2019.02.127

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  5. Overview of DNA methylation in adult diffuse gliomas

    Aoki Kosuke, Natsume Atsushi

    BRAIN TUMOR PATHOLOGY   Vol. 36 ( 2 ) page: 84-91   2019.4

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    DOI: 10.1007/s10014-019-00339-w

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  6. Inflammation Flare and Radiation Necrosis Around a Stereotactic Radiotherapy-Pretreated Brain Metastasis Site After Nivolumab Treatment.

    Furuta H, Yoshida T, Natsume A, Hida T, Yatabe Y

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer   Vol. 13 ( 12 ) page: 1975-1978   2018.12

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    DOI: 10.1016/j.jtho.2018.07.005

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  7. A randomized, double-blind, phase III trial of personalized peptide vaccination for recurrent glioblastoma.

    Narita Y, Arakawa Y, Yamasaki F, Nishikawa R, Aoki T, Kanamori M, Nagane M, Kumabe T, Hirose Y, Ichikawa T, Kobayashi H, Fujimaki T, Goto H, Takeshima H, Ueba T, Abe H, Tamiya T, Sonoda Y, Natsume A, Kakuma T, Sugita Y, Komatsu N, Yamada A, Sasada T, Matsueda S, Shichijo S, Itoh K, Terasaki M

    Neuro-oncology     2018.11

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    DOI: 10.1093/neuonc/noy200

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  8. Supratotal Resection of Diffuse Frontal Lower Grade Gliomas with Awake Brain Mapping, Preserving Motor, Language, and Neurocognitive Functions

    Motomura Kazuya, Chalise Lushun, Ohka Fumiharu, Aoki Kosuke, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Wakabayashi Toshihiko, Natsume Atsushi

    WORLD NEUROSURGERY   Vol. 119   page: 30-39   2018.11

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    DOI: 10.1016/j.wneu.2018.07.193

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  9. Characterization of lntraoperative Motor Evoked Potential Monitoring for Surgery of the Pediatric Population with Brain Tumors

    Motomura Kazuya, Sumita Kayo, Chalise Lushun, Nishikawa Tomohide, Tanahashi Kuniaki, Ohka Fumiharu, Aoki Kosuke, Hirano Masaki, Nakamura Tomohiko, Matsushita Tadashi, Wakabayashi Toshihiko, Natsume Atsushi

    WORLD NEUROSURGERY   Vol. 119   page: E1052-E1059   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2018.08.039

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  10. Validation of a novel molecular RPA classification in glioblastoma (GBM-molRPA) treated with chemoradiation: A multi-institutional collaborative study.

    Wee CW, Kim IH, Park CK, Kim JW, Dho YS, Ohka F, Aoki K, Motomura K, Natsume A, Kim N, Suh CO, Chang JH, Kim SH, Cho WK, Lim DH, Nam DH, Choi JW, Kim IA, Kim CY, Oh YT, Cho O, Chung WK, Kim SH, Kim E

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology   Vol. 129 ( 2 ) page: 347-351   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.radonc.2018.09.001

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  11. Novel Human NK Cell Line Carrying CAR Targeting EGFRvIII Induces Antitumor Effects in Glioblastoma Cells

    Murakami Toshiharu, Nakazawa Tsutomu, Natsume Atsushi, Nishimura Fumihiko, Nakamura Mitsutoshi, Matsuda Ryosuke, Omoto Koji, Tanaka Yoshitaka, Shida Youichi, Park Young-Soo, Motoyama Yasushi, Nakagawa Ichiro, Yamada Shuichi, Tamura Kentaro, Takeshima Yasuhiro, Takamura Yoshiaki, Wakabayashi Toshihiko, Nakase Hiroyuki

    ANTICANCER RESEARCH   Vol. 38 ( 9 ) page: 5049-5056   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.12824

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  12. Pediatric-Type Follicular Lymphoma in the Dura: A Case Report and Literature Review

    Yamaguchi Junya, Kato Seiichi, Iwata Eri, Aoki Kosuke, Kabeya Ryusuke, Natsume Atsushi, Wakabayashi Toshihiko

    WORLD NEUROSURGERY   Vol. 115   page: 176-180   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2018.04.053

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  13. Podoplanin: An emerging cancer biomarker and therapeutic target

    Krishnan Harini, Rayes Julie, Miyashita Tomoyuki, Ishii Genichiro, Retzbach Edward P., Sheehan Stephanie A., Takemoto Ai, Chang Yao-Wen, Yoneda Kazue, Asai Jun, Jensen Lasse, Chalise Lushun, Natsume Atsushi, Goldberg Gary S.

    CANCER SCIENCE   Vol. 109 ( 5 ) page: 1292-1299   2018.5

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    DOI: 10.1111/cas.13580

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  14. Identification of a novel fusion gene HMGA2-EGFR in glioblastoma

    Komuro Akiyoshi, Raja Erna, Iwata Caname, Soda Manabu, Isogaya Kazunobu, Yuki Keiko, Ino Yasushi, Morikawa Masato, Todo Tomoki, Aburatani Hiroyuki, Suzuki Hiromichi, Ranjit Melissa, Natsume Atsushi, Mukasa Akitake, Saito Nobuhito, Okada Hitoshi, Mano Hiroyuki, Miyazono Kohei, Koinuma Daizo

    INTERNATIONAL JOURNAL OF CANCER   Vol. 142 ( 8 ) page: 1627-1639   2018.4

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    DOI: 10.1002/ijc.31179

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  15. Immunohistochemical ATRX expression is not a surrogate for 1p19q codeletion

    Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Kato Akira, Hirano Masaki, Motomura Kazuya, Tanahashi Kuniaki, Chalise Lushun, Maeda Sachi, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

    BRAIN TUMOR PATHOLOGY   Vol. 35 ( 2 ) page: 106-113   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10014-018-0312-5

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  16. Neuroendoscopic Cylinder Surgery and 5-Aminolevulinic Acid Photodynamic Diagnosis of Deep-Seated Intracranial Lesions.

    Choo J, Takeuchi K, Nagata Y, Ohka F, Kishida Y, Watanabe T, Satoh Y, Nagatani T, Kato K, Wakabayashi T, Natsume A

    World neurosurgery     2018.3

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    DOI: 10.1016/j.wneu.2018.03.112

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  17. JCOG0911 INTEGRA study: a randomized screening phase II trial of interferonβ plus temozolomide in comparison with temozolomide alone for newly diagnosed glioblastoma.

        2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11060-018-2831-7

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  18. A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR.

    Hirano M, Ohka F, Maeda S, Chalise L, Yamamichi A, Aoki K, Kato A, Tanahashi K, Motomura K, Nishimura Y, Hara M, Shinjo K, Kondo Y, Wakabayashi T, Natsume A

    Brain tumor pathology     2018.2

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    DOI: 10.1007/s10014-018-0310-7

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  19. Chimeric Antigen Receptor Therapeutic Strategies: The Future of Glioblastoma Management

    Natsume Atsushi, Ohno Masasuke, Wakabayashi Toshihiko

    CANCER SCIENCE   Vol. 109   page: 814-814   2018.1

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  20. Prognostic relevance of genetic alterations in diffuse lower-grade gliomas

    Aoki Kosuke, Nakamura Hideo, Suzuki Hiromichi, Matsuo Keitaro, Kataoka Keisuke, Shimamura Teppei, Motomura Kazuya, Ohka Fumiharu, Shiina Satoshi, Yamamoto Takashi, Nagata Yasunobu, Yoshizato Tetsuichi, Mizoguchi Masahiro, Abe Tatsuya, Momii Yasutomo, Muragaki Yoshihiro, Watanabe Reiko, Ito Ichiro, Sanada Masashi, Yajima Hironori, Morita Naoya, Takeuchi Ichiro, Miyano Satoru, Wakabayashi Toshihiko, Ogawa Seishi, Natsume Atsushi

    NEURO-ONCOLOGY   Vol. 20 ( 1 ) page: 66-77   2018.1

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    DOI: 10.1093/neuonc/nox132

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  21. The role of CD109 in PDGFB-induced glioma mouse model for sensitivity to Temozolomide

    Shiraki Yukihiro, Mii Shinji, Asai Naoya, Enomoto Atsushi, Momota Hiroyuki, Natsume Atsushi, Wakabayashi Toshihiko, Takahashi Masahide

    CANCER SCIENCE   Vol. 109   page: 1130-1130   2018.1

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  22. Targeting Dysregulation of EZH2-H3K27me3 as an Effective Treatment for IDH-wildtype Lower Grade Glioma

    Ohka Fumiharu, Natsume Atsushi, Suzuki Hiromichi, Aoki Kosuke, Deguchi Shoichi, Katsushima Keisuke, Shinjo Keiko, Wakabayashi Toshihiko, Kondo Yutaka

    CANCER SCIENCE   Vol. 109   page: 463-463   2018.1

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  23. Symposia on Specific Tumors (SST5) [Japanese] Novel therapeutic strategies for malignant gliomas

    Ichimura Koichi, Natsume Atsushi

    CANCER SCIENCE   Vol. 109   page: 812-812   2018.1

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  24. Aberrant super-enhancers associated with downregulation of RET finger protein overcomes chemoresistance in glioblastoma

    Hirano Masaki, Ranjit Melissa, Yamamichi Akane, Aoki Kosuke, Ohka Fumiharu, Kato Takuya, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

    CANCER SCIENCE   Vol. 109   page: 461-461   2018.1

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  25. Does ATRX immunohistochemistry deserve a surrogate of 1p/19q codel in grade II, III gliomas?

    Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Hirano Masaki, Motomura Kazuya, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

    CANCER SCIENCE   Vol. 109   page: 926-926   2018.1

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  26. Development of anticancer agents targeting long non-coding RNA TUG1

    Katsushima Keisuke, Natsume Atsushi, Ohka Fumiharu, Deguchi Shoichi, Shinjo Keiko, Shibata Tatsuhiro, Miyata Kanjiro, Kataoka Kazunori, Kondo Yutaka

    CANCER SCIENCE   Vol. 109   page: 398-398   2018.1

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  27. Cytokine Therapy of Gliomas.

    Iwami K, Natsume A, Wakabayashi T

    Progress in neurological surgery   Vol. 32   page: 79-89   2018

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    DOI: 10.1159/000469682

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  28. Significance of perivascular tumour cells defined by CD109 expression in progression of glioma

    Shiraki Yukihiro, Mii Shinji, Enomoto Atsushi, Momota Hiroyuki, Han Yi-Peng, Kato Takuya, Ushida Kaori, Kato Akira, Asai Naoya, Murakumo Yoshiki, Aoki Kosuke, Suzuki Hiromichi, Ohka Fumiharu, Wakabayashi Toshihiko, Todo Tomoki, Ogawa Seishi, Natsume Atsushi, Takahashi Masahide

    JOURNAL OF PATHOLOGY   Vol. 243 ( 4 ) page: 468-480   2017.12

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    DOI: 10.1002/path.4981

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  29. Identification of a novel fusion gene HMGA2-EGFR in glioblastoma Reviewed

    Komuro A, Raja E, Iwata C, Soda M, Isogaya K, Yuki K, Ino Y, Morikawa M, Todo T, Aburatani H, Suzuki H, Ranjit M, Natsume A, Mukasa A, Saito N, Okada H, Mano H, Miyazono K, Koinuma D.

    Int J Cancer.     page: doi: 10.1002/ijc.31179.   2017.11

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    DOI: 10.1002/ijc.31179.

  30. IS ATRX IMMUNOCHEMISTRY USEFUL AS A SUBSTITUTE FOR ANALYSIS OF 1p/19q CODELETION IN GRADES II, III GLIOMAS?

    Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Hirano Masaki, Motomura Kazuya, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

    NEURO-ONCOLOGY   Vol. 19   page: 180-180   2017.11

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  31. Remote ischemic preconditioning protects human neural stem cells from oxidative stress

    Motomura Ayako, Shimizu Mikiko, Kato Akira, Motomura Kazuya, Yamamichi Akane, Koyama Hiroko, Ohka Fumiharu, Nishikawa Tomohide, Nishimura Yusuke, Hara Masahito, Fukuda Tetsuya, Bando Yasuhiko, Nishimura Toshihide, Wakabayashi Toshihiko, Natsume Atsushi

    APOPTOSIS   Vol. 22 ( 11 ) page: 1353-1361   2017.11

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    DOI: 10.1007/s10495-017-1425-8

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  32. POLYION COMPLEX-MEDIATED INTRAVENOUS DELIVERY OF ANTISENSE OLIGONUCLEOTIDES AGAINST THE NOTCH-REGULATED NON-CODING RNA TUG1 IN GLIOMA

    Natsume Atsushi, Katsushima Keisuke, Ohka Fumiharu, Shinjo Keiko, Miyata Kanjiro, Kataoka Kazunori, Kondo Yutaka

    NEURO-ONCOLOGY   Vol. 19   page: 265-265   2017.11

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  33. ABERRANT SUPER-ENHANCERS ASSOCIATED WITH DOWNREGULATION OF RET FINGER PROTEIN OVERCOMES CHEMORESISTANCE IN GLIOBLASTOMA

    Hirano Masaki, Ranjit Melissa, Yamamichi Akane, Aoki Kosuke, Ohka Fumiharu, Kato Takuya, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

    NEURO-ONCOLOGY   Vol. 19   page: 103-103   2017.11

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  34. Surgical benefits of combined awake craniotomy and intraoperative magnetic resonance imaging for gliomas associated with eloquent areas

    Motomura Kazuya, Natsume Atsushi, Iijima Kentaro, Kuramitsu Shunichiro, Fujii Masazumi, Yamamoto Takashi, Maesawa Satoshi, Sugiura Junko, Wakabayashi Toshihiko

    JOURNAL OF NEUROSURGERY   Vol. 127 ( 4 ) page: 790-797   2017.10

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    DOI: 10.3171/2016.9.JNS16152

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  35. Comparing the Efficacy of DeVIC Therapy and High-dose Methotrexate Monotherapy with Whole-brain Radiation Therapy for Newly-diagnosed Primary Central Nervous System Lymphoma: A Single Institution Study

    Chalise Lushun, Motomura Kazuya, Ohka Fumiharu, Hirano Masaki, Hara Masahito, Nishimura Yusuke, Natsume Atsushi, Wakabayashi Toshihiko

    ANTICANCER RESEARCH   Vol. 37 ( 9 ) page: 5215-5223   2017.9

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    DOI: 10.21873/anticanres.11945

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  36. Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis

    Deguchi S., Katsushima K., Hatanaka A., Shinjo K., Ohka F., Wakabayashi T., Zong H., Natsume A., Kondo Y.

    ONCOGENE   Vol. 36 ( 32 ) page: 4629-4640   2017.8

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    DOI: 10.1038/onc.2017.88

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  37. PHASE I TRIAL OF TEMOZOLOMIDE PLUS BEVACIZUMAB FOR NEWLY DIAGNOSED HIGH-GRADE GLIOMAS IN THE ELDERLY: INTERIM REPORT

    Kono M., Arakawa Y., Mineharu Y., Ohka F., Kinoshita M., Nakae S., Miyashita K., Iuchi T., Hirose Y., Natsume A., Nakada M., Sasaki H.

    NEURO-ONCOLOGY   Vol. 19   page: 81-81   2017.5

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  38. Synthesis of PET probe O-6-[(3-[C-11]methyl)benzyl]guanine by Pd-0-mediated rapid C-[C-11]methylation toward imaging DNA repair protein O-6-methylguanine-DNA methyltransferase in glioblastoma

    Koyama Hiroko, Ikenuma Hiroshi, Toda Hiroshi, Kondo Goro, Hirano Masaki, Kato Masaya, Abe Junichiro, Yamada Takashi, Wakabayashi Toshihiko, Ito Kengo, Natsume Atsushi, Suzuki Masaaki

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   Vol. 27 ( 9 ) page: 1892-1896   2017.5

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    DOI: 10.1016/j.bmcl.2017.03.045

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  39. Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells

    Han Yi-Peng, Enomoto Atsushi, Shiraki Yukihiro, Wang Shen-Qi, Wang Xiaoze, Toyokuni Shinya, Asai Naoya, Ushida Kaori, Ara Hosne, Ohka Fumiharu, Wakabayashi Toshihiko, Ma Jie, Natsume Atsushi, Takahashi Masahide

    NEURO-ONCOLOGY   Vol. 19 ( 5 ) page: 636-647   2017.5

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    DOI: 10.1093/neuonc/now237

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  40. A novel all-in-one intraoperative genotyping system for IDH1-mutant glioma

    Ohka Fumiharu, Yamamichi Akane, Kurimoto Michihiro, Motomura Kazuya, Tanahashi Kuniaki, Suzuki Hiromichi, Aoki Kosuke, Deguchi Shoichi, Chalise Lushun, Hirano Masaki, Kato Akira, Nishimura Yusuke, Hara Masahito, Kato Yukinari, Wakabayashi Toshihiko, Natsume Atsushi

    BRAIN TUMOR PATHOLOGY   Vol. 34 ( 2 ) page: 91-97   2017.4

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    DOI: 10.1007/s10014-017-0281-0

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  41. The chimeric antibody NZ-12 or CAR T cells targeting human podoplanin possesses antitumor activity against orthotopic xenograft models

    Kato Yukinari, Shiina Satoshi, Natsume Atsushi, Abe Shinji, Nishioka Yasuhiko, Ogasawara Satoshi, Kaneko Mika K.

    CANCER IMMUNOLOGY RESEARCH   Vol. 5 ( 3 )   2017.3

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    DOI: 10.1158/2326-6074.TUMIMM16-B89

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  42. Development of Database and Genomic Medicine for von Hippel-Lindau Disease in Japan

    Takayanagi Shunsaku, Mukasa Akitake, Nakatomi Hirofumi, Kanno Hiroshi, Kuratsu Jun-ichi, Nishikawa Ryo, Mishima Kazuhiko, Natsume Atushi, Wakabayashi Toshihiko, Houkin Kiyohiro, Terasaka Shunsuke, Yao Masahiro, Shinohara Nobuo, Shuin Taro, Saito Nobuhito

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 57 ( 2 ) page: 59-65   2017.2

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    DOI: 10.2176/nmc.ra.2016-0206

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  43. Efficacy of the transtemporal approach with awake brain mapping to reach the dominant posteromedial temporal lesions

    Iijima Kentaro, Motomura Kazuya, Chalise Lushun, Hirano Masaki, Natsume Atsushi, Wakabayashi Toshihiko

    ACTA NEUROCHIRURGICA   Vol. 159 ( 1 ) page: 177-184   2017.1

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    DOI: 10.1007/s00701-016-3035-6

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  44. CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains. Reviewed

    Shiina S, Ohno M, Ohka F, Kuramitsu S, Yamamichi A, Kato A, Motomura K, Tanahashi K, Yamamoto T, Watanabe R, Ito I, Senga T, Hamaguchi M, Wakabayashi T, Kaneko MK, Kato Y, Chandramohan V, Bigner DD, Natsume A.

    Cancer Immunol Res.   Vol. 4 ( 3 ) page: 259-68.   2016.3

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    DOI: 10.1158/2326-6066.

  45. Efficacy of early carotid endarterectomy for vulnerable plaque in the common carotid artery. Reviewed

    Tanahashi K, Araki Y, Maruwaka M, Natsume A.

    Acta Neurochir (Wien).     2016.1

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  46. Rapid sensitive analysis of IDH1 mutation in lower-grade gliomas by automated genetic typing involving a quenching probe. Reviewed

    Kurimoto M, Suzuki H, Aoki K, Ohka F, Kondo G, Motomura K, Iijima K, Yamamichi A, Ranjit M, Wakabayashi T, Kimura S, Natsume A.

    Cancer Invest.   Vol. 34 ( 2 ) page: 12   2016.1

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    DOI: 10.3109/07357907.2015.1084001.

  47. Lenalidomide enhances the function of chimeric antigen receptor T cells against the epidermal growth factor receptor variant III by enhancing immune synapses. Reviewed

    Kuramitsu S, Ohno M, Ohka F, Shiina S, Yamamichi A, Kato A, Tanahashi K, Motomura K, Kondo G, Kurimoto M, Senga T, Wakabayashi T, Natsume A.

    Cancer Gene Ther.     2015.10

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    DOI: 10.1038/cgt.2015.47.

  48. Antitumorigenic effect of interferon-β by inhibition of undifferentiated glioblastoma cells. Reviewed

    Yamamuro S, Sano E, Okamoto Y, Ochiai Y, Ohta T, Ogino A, Natsume A, Wakabayashi T, Ueda T, Hara H, Nakayama T, Yoshino A, Katayama Y.

    Int J Oncol.     2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ijo.2015.3165.

  49. Assessment of tumor cells in a mouse model of diffuse infiltrative glioma by Raman spectroscopy. Reviewed

    Tanahashi K, Natsume A, Ohka F, Momota H, Kato A, Motomura K, Watabe N, Muraishi S, Nakahara H, Saito Y, Takeuchi I, Wakabayashi T.

    Biomed Res Int.     2015.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2014/860241.

  50. Activation of Yes-Associated Protein in Low-Grade Meningiomas Is Regulated by Merlin, Cell Density, and Extracellular Matrix Stiffness. Reviewed

    Tanahashi K, Natsume A, Ohka F, Motomura K, Alim A, Tanaka I, Senga T, Harada I, Fukuyama R, Sumiyoshi N, Sekido Y, Wakabayashi T.

    J Neuropathol Exp Neurol.   Vol. 74 ( 4 ) page: 704   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/NEN.0000000000000211.

  51. Applicable advances in the molecular pathology of glioblastoma. Reviewed

    Ranjit M, Motomura K, Ohka F, Wakabayashi T, Natsume A.

    Brain Tumor Pathol.   Vol. 32 ( 3 ) page: 153   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10014-015-0224-6.

  52. Effectiveness of plasma treatment on gastric cancer cells. Reviewed

    Torii K, Yamada S, Nakamura K, Tanaka H, Kajiyama H, Tanahashi K, Iwata N, Kanda M, Kobayashi D, Tanaka C, Fujii T, Nakayama G, Koike M, Sugimoto H, Nomoto S, Natsume A, Fujiwara M, Mizuno M, Hori M, Saya H, Kodera Y.

    Gastric Cancer.   Vol. 18 ( 3 ) page: 635   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10120-014-0395-6.

  53. Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase. Reviewed

    Ohkawa Y, Momota H, Kato A, Hashimoto N, Tsuda Y, Kotani N, Honke K, Suzumura A, Furukawa K, Ohmi Y, Natsume A, Wakabayashi T, Furukawa K.

    J Biol Chem.   Vol. 290 ( 26 ) page: 16043   2015.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M114.635755.

  54. Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells. Reviewed

    Sugiyama M, Hasegawa H, Ito S, Sugiyama K, Maeda M, Aoki K, Wakabayashi T, Hamaguchi M, Natsume A, Senga T.

    Oncol Rep.   Vol. 33 ( 3 ) page: 1123   2015.5

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    DOI: 10.1155/2014/860241.

  55. Mutational landscape and clonal architecture in grade II and III gliomas. Reviewed

    Suzuki H, Aoki K, Chiba K, Sato Y, Shiozawa Y, Shiraishi Y, Shimamura T, Niida A, Motomura K, Ohka F, Yamamoto T, Tanahashi K, Ranjit M, Wakabayashi T, Yoshizato T, Kataoka K, Yoshida K, Nagata Y, Sato-Otsubo A, Tanaka H, Sanada M, Kondo Y, Nakamura H, Mizoguchi M, Abe T, Muragaki Y, Watanabe R, Ito I, Miyano S, Natsume A, Ogawa S.

    Nat Genet.   Vol. 47 ( 5 ) page: 458   2015.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ng.3273.

  56. Anaplastic meningioma with rapid growth after omental flap transposition: a case report and experimental study. Reviewed

    Iwami K, Momota H, Fujii M, Natsume A, Yagi S, Toriyama K, Kamei Y, Wakabayashi T.

    Brain Tumor Pathol.   Vol. 32 ( 2 ) page: 137   2015.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10014-014-0190-4.

  57. Blockade of gap junction hemichannel protects secondary spinal cord injury from activated microglia-mediated glutamate exitoneurotoxicity. Reviewed

    Umebayashi D, Natsume A, Takeuchi H, Hara M, Nishimura Y, Fukuyama R, Sumiyoshi N, Wakabayashi T.

    J Neurotrauma.   Vol. 31 ( 24 ) page: 1967   2014.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/neu.2013.3223.

  58. Olig2 labeling index is correlated with histological and molecular classifications in low-grade diffuse gliomas. Reviewed

    Suzuki A, Nobusawa S, Natsume A, Suzuki H, Kim YH, Yokoo H, Nagaishi M, Ikota H, Nakazawa T, Wakabayashi T, Ohgaki H, Nakazato Y.

    J Neurooncol.   Vol. 120 ( 2 ) page: 283   2014.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11060-014-1568-1.

  59. Assessment of tumor cells in a mouse model of diffuse infiltrative glioma by Raman spectroscopy. Reviewed

    Tanahashi K, Natsume A, Ohka F, Momota H, Kato A, Motomura K, Watabe N, Muraishi S, Nakahara H, Saito Y, Takeuchi I, Wakabayashi T

    Biomed Res Int     page: 860241   2014.10

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  60. Papillary glioneuronal tumor with a high proliferative component and minigemistocytes in a child. Reviewed

    Momota H, Fujii M, Tatematsu A, Shimoyama Y, Tsujiuchi T, Ohno M, Natsume A, Wakabayashi T.

    Neuropathology.   Vol. 34 ( 5 ) page: 484   2014.10

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    DOI: 10.1111/neup.12123.

  61. Spinal dural arteriovenous fistula associated with L-4 isthmic spondylolisthesis. Reviewed

    Nishimura Y, Natsume A, Ginsberg HJ.

    J Neurosurg Spine.   Vol. 20 ( 6 ) page: 670   2014.10

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    DOI: 10.3171/2014.3.SPINE13492

  62. Olig2 labeling index is correlated with histological and molecular classifications in low-grade diffuse gliomas. Reviewed

    Suzuki A, Nobusawa S, Natsume A, Suzuki H, Kim YH, Yokoo H, Nagaishi M, Ikota H, Nakazawa T, Wakabayashi T, Ohgaki H, Nakazato Y.

    J Neurooncol.   Vol. 120 ( 2 ) page: 635   2014.8

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    DOI: 10.1007/s11060-014-1568-1.

  63. Novel somatic and germline mutations in intracranial germ cell tumours. Reviewed

    Wang L, Yamaguchi S, Burstein MD, Terashima K, Chang K, Ng HK, Nakamura H, He Z, Doddapaneni H, Lewis L, Wang M, Suzuki T, Nishikawa R, Natsume A, Terasaka S, Dauser R, Whitehead W, Adekunle A, Sun J, Qiao Y, Marth G, Muzny DM, Gibbs RA, Leal SM, Wheeler DA, Lau CC.

    Nature   Vol. 511 ( 7508 ) page: 241   2014.7

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  64. Association of dorsal inferior frontooccipital fasciculus fibers in the deep parietal lobe with both reading and writing processes: a brain mapping study. Reviewed

    Motomura K, Fujii M, Maesawa S, Kuramitsu S, Natsume A, Wakabayashi T.

    J Neurosurg.   Vol. 121 ( 1 ) page: 142   2014.7

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    DOI: 10.3171/2014.2.JNS131234.

  65. Lack of presence of the human cytomegalovirus in human glioblastoma. Reviewed

    Yamashita Y, Ito Y, Isomura H, Takemura N, Okamoto A, Motomura K, Tsujiuchi T, Natsume A, Wakabayashi T, Toyokuni S, Tsurumi T.

    Mod Pathol.   Vol. 27 ( 7 ) page: 922   2014.7

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    DOI: 10.1038/modpathol.2013.219.

  66. Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation. Reviewed

    Ohka F, Ito M, Ranjit M, Senga T, Motomura A, Motomura K, Saito K, Kato K, Kato Y, Wakabayashi T, Soga T, Natsume A.

    Tumour Biol.   Vol. 35 ( 6 ) page: 5911   2014.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s13277-014-1784-5.

  67. Epigenetic dysregulation in glioma. Invited Reviewed

    Kondo Y, Katsushima K, Ohka F, Natsume A, Shinjo K.

    Cancer Sci.   Vol. 105 ( 4 ) page: 363   2014.4

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  68. Progressively unstable c2 spondylolysis requiring spinal fusion: case report. Reviewed

    Nishimura Y, Ellis MJ, Anderson J, Hara M, Natsume A, Ginsberg HJ.

    Neurol Med Chir (Tokyo).   Vol. 54 ( 9 ) page: 761   2014.2

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  69. Preclinical evaluation of an O(6)-methylguanine-DNA methyltransferase-siRNA/liposome complex administered by convection-enhanced delivery to rat and porcine brains. Reviewed

    Tsujiuchi T, Natsume A, Motomura K, Kondo G, Ranjit M, Hachisu R, Sugimura I, Tomita S, Takehara I, Woolley M, Barua NU, Gill SS, Bienemann AS, Yamashita Y, Toyokuni S, Wakabayashi T.

    Am J Transl Res.   Vol. 6 ( 2 ) page: 169   2014.1

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  70. Peptide-based inhibition of the HOXA9/PBX interaction retards the growth of human meningioma. Reviewed

    Ando H, Natsume A, Senga T, Watanabe R, Ito I, Ohno M, Iwami K, Ohka F, Motomura K, Kinjo S, Ito M, Saito K, Morgan R, Wakabayashi T.

    Cancer Chemother Pharmacol.   Vol. 73 ( 1 ) page: 53   2014.1

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    DOI: 10.1007/s00280-013-2316-5.

  71. Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts. Reviewed

    Ohno M, Ohkuri T, Kosaka A, Tanahashi K, June CH, Natsume A, Okada H.

    J Immunother Cancer.   Vol. 1   page: 21   2013.12

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    DOI: 10.1186/2051-1426-1-21.

  72. Spinal intradural cystic venous angioma originating from a nerve root in the cauda equina. Reviewed

    Nishimura Y, Hara M, Natsume A, Nakajima Y, Fukuyama R, Wakabayashi T, Ginsberg HJ.

    J Neurosurg Spine.   Vol. 19 ( 6 ) page: 716   2013.12

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    DOI: 10.3171/2013.8.SPINE121012.

  73. [Chemotherapy for malignant gliomas: an update]. Invited Reviewed

    Gan To Kagaku Ryoho.   Vol. 40 ( 10 ) page: 1283   2013.10

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  74. The role of PLK1-phosphorylated SVIL in myosin II activation and cytokinetic furrowing. Reviewed

    Hasegawa H, Hyodo T, Asano E, Ito S, Maeda M, Kuribayashi H, Natsume A, Wakabayashi T, Hamaguchi M, Senga T.

    J Cell Sci.   Vol. 126 ( 16 ) page: 3627   2013.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1242/jcs.124818.

  75. Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. Reviewed

    Natsume A, Ito M, Katsushima K, Ohka F, Hatanaka A, Shinjo K, Sato S, Takahashi S, Ishikawa Y, Takeuchi I, Shimogawa H, Uesugi M, Okano H, Kim SU, Wakabayashi T, Issa JP, Sekido Y, Kondo Y.

    Cancer Res.   Vol. 73 ( 14 ) page: 4559   2013.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/0008-5472.

  76. [IV. Epigenetic analysis for stem cell of brain cancer and treatment]. Invited Reviewed

    Gan To Kagaku Ryoho.   Vol. 40 ( 6 ) page: 723   2013.7

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  77. Adoptive transfer of genetically modified Wilms' tumor 1-specific T cells in a novel malignant skull base meningioma model. Reviewed

    Iwami K, Natsume A, Ohno M, Ikeda H, Mineno J, Nukaya I, Okamoto S, Fujiwara H, Yasukawa M, Shiku H, Wakabayashi T.

    Neuro Oncol.   Vol. 15 ( 6 ) page: 747   2013.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/neuonc/not007.

  78. Establishment of novel monoclonal antibodies KMab-1 and MMab-1 specific for IDH2 mutations. Reviewed

    Kaneko MK, Morita S, Tsujimoto Y, Yanagiya R, Nasu K, Sasaki H, Hozumi Y, Goto K, Natsume A, Watanabe M, Kumabe T, Takano S, Kato Y.

    Biochem Biophys Res Commun.   Vol. 432 ( 1 ) page: 40   2013.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2013.01.088.

  79. A hypoxia-inducible factor (HIF)-3α splicing variant, HIF-3α4 impairs angiogenesis in hypervascular malignant meningiomas with epigenetically silenced HIF-3α4. Reviewed

    Ando H, Natsume A, Iwami K, Ohka F, Kuchimaru T, Kizaka-Kondoh S, Ito K, Saito K, Sugita S, Hoshino T, Wakabayashi T.

    Biochem Biophys Res Commun.   Vol. 433 ( 1 ) page: 139   2013.3

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    DOI: 10.1016/j.bbrc.2013.02.044.

  80. A novel monoclonal antibody GMab-m1 specifically recognizes IDH1-R132G mutation. Reviewed

    Kato Y, Natsume A, Kaneko MK.

    Biochem Biophys Res Commun.   Vol. 432 ( 4 ) page: 564   2013.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2013.02.049.

  81. Clinical features of patients bearing central nervous system hemangioblastoma in von Hippel-Lindau disease. Reviewed

    Kanno H, Kuratsu J, Nishikawa R, Mishima K, Natsume A, Wakabayashi T, Houkin K, Terasaka S, Shuin T.

    Acta Neurochir (Wien).   Vol. 155   page: 1   2013.1

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    DOI: 10.1007/s00701-012-1514-y.

  82. Interferon-β delivery via human neural stem cell abates glial scar formation in spinal cord injury. Reviewed

    Nishimura Y, Natsume A, Ito M, Hara M, Motomura K, Fukuyama R, Sumiyoshi N, Aoki I, Saga T, Lee HJ, Wakabayashi T, Kim SU.

    Cell Transplant.   Vol. 22 ( 12 ) page: 2187   2013.1

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    DOI: 10.3727/096368912X657882.

  83. Neural stem cell-based dual suicide gene delivery for metastatic brain tumors. Reviewed

    Wang C, Natsume A, Lee HJ, Motomura K, Nishimira Y, Ohno M, Ito M, Kinjo S, Momota H, Iwami K, Ohka F, Wakabayashi T, Kim SU.

    Cancer Gene Ther.   Vol. 19 ( 11 ) page: 796   2012.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/cgt.2012.63.

  84. Immunohistochemical analysis-based proteomic subclassification of newly diagnosed glioblastomas. Reviewed

    Motomura K, Natsume A, Watanabe R, Ito I, Kato Y, Momota H, Nishikawa R, Mishima K, Nakasu Y, Abe T, Namba H, Nakazato Y, Tashiro H, Takeuchi I, Mori T, Wakabayashi T.

    Cancer Sci.   Vol. 103 ( 10 ) page: 1871   2012.10

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    DOI: 10.1111/j.1349-7006.2012.02377.x.

  85. Contribution of microRNA-1275 to Claudin11 protein suppression via a polycomb-mediated silencing mechanism in human glioma stem-like cells. Reviewed

    Katsushima K, Shinjo K, Natsume A, Ohka F, Fujii M, Osada H, Sekido Y, Kondo Y.

    J Biol Chem.   Vol. 287 ( 33 ) page: 27396   2012.8

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    DOI: 10.1074/jbc.M112.359109.

  86. Peptide-pulsed dendritic cell vaccination targeting interleukin-13 receptor α2 chain in recurrent malignant glioma patients with HLA-A*24/A*02 allele. Reviewed

    Iwami K, Shimato S, Ohno M, Okada H, Nakahara N, Sato Y, Yoshida J, Suzuki S, Nishikawa H, Shiku H, Natsume A, Wakabayashi T.

    Cytotherapy.   Vol. 16 ( 6 ) page: 733-42   2012.7

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    DOI: 10.3109/14653249.2012.666633.

  87. Correlation between quantified promoter methylation and enzymatic activity of O6-methylguanine-DNA methyltransferase in glioblastomas. Reviewed

    Kishida Y, Natsume A, Toda H, Toi Y, Motomura K, Koyama H, Matsuda K, Nakayama O, Sato M, Suzuki M, Kondo Y, Wakabayashi T.

    Tumour Biol.   Vol. 33 ( 2 ) page: 373   2012.4

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    DOI: 10.1007/s13277-012-0319-1.

  88. Girdin maintains the stemness of glioblastoma stem cells. Reviewed

    Natsume A, Kato T, Kinjo S, Enomoto A, Toda H, Shimato S, Ohka F, Motomura K, Kondo Y, Miyata T, Takahashi M, Wakabayashi T.

    Oncogene   Vol. 31 ( 22 ) page: 2715   2012.3

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    DOI: 10.1038/onc.2011.466.

  89. Current trends in targeted therapies for glioblastoma multiforme. Reviewed

    Ohka F, Natsume A, Wakabayashi T.

    Neurol Res Int.   Vol. 2012 ( 2012 ) page: 878425   2012.3

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    DOI: 10.1155/2012/878425.

  90. A novel method of intracranial injection via the postglenoid foramen for brain tumor mouse models. Reviewed

    Iwami K, Momota H, Natsume A, Kinjo S, Nagatani T, Wakabayashi T.

    J Neurosurg.   Vol. 116 ( 3 ) page: 630   2012.3

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    DOI: 10.1007/s13277-012-0319-1.

  91. Epigenetic subclassification of meningiomas based on genome-wide DNA methylation analyses. Reviewed

    Kishida Y, Natsume A, Kondo Y, Takeuchi I, An B, Okamoto Y, Shinjo K, Saito K, Ando H, Ohka F, Sekido Y, Wakabayashi T.

    Carcinogenesis   Vol. 33 ( 2 ) page: 436   2012.2

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    DOI: 10.1093/carcin/bgr260.

  92. Intra-extradural dumbbell-shaped hemangioblastoma manifesting as subarachnoid hemorrhage in the cauda equina. Reviewed

    Nishimura Y, Hara M, Natsume A, Takemoto M, Fukuyama R, Wakabayashi T.

    Neurol Med Chir (Tokyo).   Vol. 52 ( 9 ) page: 659   2012.1

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  93. Cytokine therapy. Invited Reviewed

    Ohno M, Natsume A, Wakabayashi T.

    Adv Exp Med Biol.   Vol. 746   page: 86   2012.1

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    DOI: 10.1007/978-1-4614-3146-6_7.

  94. Intravenous administration of temozolomide as a useful alternative over oral treatment with temozolomide capsules in patients with gliomas. Reviewed

    Motomura K, Natsume A, Wakabayashi T.

    J Neurooncol.   Vol. 106 ( 1 ) page: 209   2012.1

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    DOI: 10.1007/s11060-011-0651-0.

  95. Long-term survival in patients with newly diagnosed primary central nervous system lymphoma treated with dexamethasone, etoposide, ifosfamide and carboplatin chemotherapy and whole-brain radiation therapy. Reviewed

    Motomura K, Natsume A, Fujii M, Ito M, Momota H, Wakabayashi T.

    Leuk Lymphoma.   Vol. 52 ( 22 ) page: 2069   2011.11

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    DOI: 10.3109/10428194.2011.596967.

  96. The global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma. Reviewed

    Ohka F, Natsume A, Motomura K, Kishida Y, Kondo Y, Abe T, Nakasu Y, Namba H, Wakai K, Fukui T, Momota H, Iwami K, Kinjo S, Ito M, Fujii M, Wakabayashi T.

    PLoS One.     page: 2011;6(8):e23332.   2011.8

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    DOI: 10.1371/journal.pone.0023332.

  97. A multicenter phase I trial of combination therapy with interferon-β and temozolomide for high-grade gliomas (INTEGRA study): the final report. Reviewed

    Wakabayashi T, Kayama T, Nishikawa R, Takahashi H, Hashimoto N, Takahashi J, Aoki T, Sugiyama K, Ogura M, Natsume A, Yoshida J.

    J Neurooncol.   Vol. 104 ( 2 ) page: 573   2011.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11060-011-0529-1.

  98. Cytokine networks in glioma. Invited Reviewed

    Iwami K, Natsume A, Wakabayashi T.

    Neurosurg Rev.   Vol. 34 ( 3 ) page: 253   2011.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10143-011-0320-y.

  99. Benefits of interferon-β and temozolomide combination therapy for newly diagnosed primary glioblastoma with the unmethylated MGMT promoter: A multicenter study. Reviewed

    Motomura K, Natsume A, Kishida Y, Higashi H, Kondo Y, Nakasu Y, Abe T, Namba H, Wakai K, Wakabayashi T.

    Cancer   Vol. 117 ( 8 ) page: 1721   2011.4

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    DOI: 10.1002/cncr.25637.

  100. Rhabdoid glioblastoma in a child: case report and literature review. Reviewed

    Momota H, Iwami K, Fujii M, Motomura K, Natsume A, Ogino J, Hasegawa T, Wakabayashi T.

    Brain Tumor Pathol.   Vol. 28 ( 1 ) page: 65   2011.2

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    DOI: 10.1007/s10014-010-0011-3.

  101. Glioma-initiating cells and molecular pathology: implications for therapy.

    Natsume A, Kinjo S, Yuki K, Kato T, Ohno M, Motomura K, Iwami K, Wakabayashi T.

    Brain Tumor Pathol.   Vol. 28 ( 1 ) page: 65   2011.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10014-010-0011-3.

  102. A combination of IFN-beta and temozolomide in human glioma xenograft models: implication of p53-mediated MGMT downregulation. Reviewed

    Natsume A, Wakabayashi T, Ishii D, Maruta H, Fujii M, Shimato S, Ito M, Yoshida J.

    Cancer Chemother Pharmacol.   Vol. 61 ( 4 ) page: 653-9   2008.4

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Books 6

  1. 脳腫瘍取扱い規約(第3版)

    夏目敦至( Role: Joint author)

    金原出版  2010.4 

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    Language:Japanese

  2. 脳腫瘍臨床病理カラーアトラス第3版

    夏目敦至( Role: Sole author)

    に本臨床  2010.4 

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    Language:Japanese

  3. 脳腫瘍―ゲノム異常の最新アトラスー.遺伝子診療学(第2版)

    夏目敦至( Role: Sole author)

    に本臨床  2010.4 

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    Language:Japanese

  4. ヘルペスウイルス学

    夏目敦至( Role: Joint author)

    日本臨床社  2006.3 

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    Language:Japanese

  5. Delivery of herpes simplex virus-based vectors to the nervous system.

    Goss JR, Natsume A, Wolfe D, Mata M, Glorioso JC, Fink DJ( Role: Joint author)

    Methods Mol Biol.  2004 

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    Language:English

  6. ヘルペスウイルスベクターの開発と神経疾患の遺伝子治療.「新臨床医のための分子医学シリーズ 遺伝子治療の新展開

    夏目敦至( Role: Joint author)

    羊土社  2001 

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    Language:Japanese

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Presentations 233

  1. Brain functional mapping and awake craniotomy for brain tumors Invited International conference

    Atsushi Natsume

    The 23rd Annual Scientific Meeting of ISNS in conjunction with The WFNS Educational Course 

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    Event date: 2019.8

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Indonesia  

  2. Molecular and genetic classification of brain tumors Invited International conference

    Atsushi Natsume

    WFNS Educational Course and The 23rd of Annual Scientific Meeting of ISNS 2019 

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    Event date: 2019.8

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Indonesia  

  3. Phase I study of a brain penetrant mutant IDH1 inhibitor DS-1001b in patients with recurrent or progressive IDH1 mutant gliomas International conference

    Atsushi Natsume, MD, PhD1, Toshihiko Wakabayashi, MD, PhD1, Yasuji Miyakita, MD, PhD2, Yoshitaka Narita, MD, PhD2, Yohei Mineharu, MD, PhD3, Yoshiki Arakawa, MD, PhD3,

    2019 American Society of Clinical Oncology Annual Meeting  

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    Event date: 2019.5 - 2019.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  4. Mathematical prediction for precision medicine of CNS glial tumors International conference

    Atsushi Natsume, Kosuke Aoki

    11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Precision Medicine 

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    Event date: 2019.2

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  5. シングル細胞レベルのCell AtlasとAIを用いた脳腫瘍治療への展望 Invited

    夏目敦至

    第38回日本脳神経外科コングレス総会 

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    Event date: 2018.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:大阪   Country:Japan  

  6. ゲノム時代におけるグリオーマの治療戦略 Invited

    夏目敦至

    第22回北海道脳腫瘍懇話会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:札幌   Country:Japan  

  7. Genome-based Precision Medicine in Brain Tumors International conference

    Atsushi Natsume

    First Joint US-Japan Clinical Cancer Genomics and Personalized Medicine Symposium 

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    Event date: 2018.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Tokyo   Country:Japan  

  8. 小児脳腫瘍におけるゲノム解析のレビュー International conference

    夏目敦至

    小児血液・がんセミナーin 中部 

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    Event date: 2016.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋   Country:Japan  

  9. Clinical relevance of the molecular classificaton of lower-grade gliomas International conference

    Atsushi Natsume

    The 7th Taiwan-Japan Sympoium on Nanomidicine 

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    Event date: 2016.1

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  10. Clinical relevance of the molecular classification International conference

    Atsushi Natsume

    International Symposium of Nanomedicne Molecular Science, 2015 

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    Event date: 2015.12

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  11. 名古屋大学附属病院における遺伝性脳腫瘍のネットワークの構築

    夏目敦至

    第33回日本脳腫瘍学会学術集会 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都、京都   Country:Japan  

  12. 神経膠腫のゲノムシークエンシングと新規治療への展望

    夏目敦至

    日本癌治療学会学術集会 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:京都国際会館、京都   Country:Japan  

  13. Landscape of aberrations of genome, epigenome and trasncriptome in brain cancers International conference

    Atsushi Natsume

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    Event date: 2015.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  14. Prognostic Relevance of genotypes in grade II and III gliomas International conference

    Atsushi Natsume

    2015 Current Trends in the Management of Malignant Gliomas 

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    Event date: 2015.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  15. Exploration of Biomarkers to predict glioma prognosis

    Atsushi Natsume

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    Event date: 2015.7

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  16. 757例におけるグレードII, III神経膠腫における遺伝子プロファイリングとクローン階層化におえる予後解析

    夏目敦至

    次世代-医理工連携-研究会 

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    Event date: 2015.7

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:豊橋、愛知県   Country:Japan  

  17. 遺伝子解析と分子トレーシングを基盤とした細胞標的分子の創製

    Nanomedine Molecular Science 

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    Event date: 2015.7

    Language:English   Presentation type:Oral presentation (keynote)  

    Venue:東京   Country:Japan  

  18. 東海小児脳腫瘍研究の方向性

    夏目敦至

    第13回東海小児脳腫瘍研究会 

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    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Venue:名古屋、愛知県   Country:Japan  

  19. 悪性脳腫瘍 International conference

    夏目敦至

    日本脳神経財団講習会 

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    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  20. 日本の底力を見せたオールジャパンのグレード2/3神経膠腫の次世代シークエンスの網羅的解析

    夏目敦至

    第17回三重・大阪脳腫瘍カンファレンス 

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    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:津、三重県   Country:Japan  

  21. 757例におけるグレードII, III神経膠腫における遺伝子プロファイリングとクローン階層化におえる予後解析 International conference

    夏目敦至

    第33回日本脳腫瘍病理学会 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:高松、香川県   Country:Japan  

  22. グリオーマ治療の陰影礼賛 International conference

    夏目敦至

    第35回日本脳神経外科コングレス 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:横浜、神奈川   Country:Japan  

  23. 脳神経外科医が病理診断に期待すること International conference

    夏目敦至

    第104回日本病理学会 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:名古屋   Country:Japan  

  24. 脳腫瘍のゲノム解析と治療のUpdate International conference

    夏目敦至

    第12回神戸脳腫瘍カンファレンス 

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    Event date: 2015.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:神戸   Country:Japan  

  25. 日本における結節性硬化症標準治療を目指して International conference

    夏目敦至

    東海小児神経研究会 

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    Event date: 2015.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  26. Clinical application of Raman spectroscopy in Neurosurgery International conference

    Natsume A

    1st Raman-Bio-sensing Seminar 

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    Event date: 2015.1

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  27. 悪性脳腫瘍における遺伝子異常による多段階発がんメカニズムの解明

    夏目敦至

    MERRO 第1 回次世代若手研究会 

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    Event date: 2015.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:蒲郡(愛知)   Country:Japan  

  28. AV shunt を伴う大型小児悪性脳腫瘍に対し中大脳動脈本幹からparticleを用い術前塞栓術を施行した一例

    夏目敦至

    第30回NPO 法人日本脳神経血管内治療学会学術総会 

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    Event date: 2014.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  29. テモダールの陰翳礼賛から学ぶ悪性神経膠腫の神秘

    夏目敦至

    第32回日本脳腫瘍学会 

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    Event date: 2014.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  30. GBMに対するPodoplanin特異的キメラ抗原受容体を発現するT細胞の抗腫瘍効果の検討

    夏目敦至

    第32回日本脳腫瘍学会学術集会 

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    Event date: 2014.11 - 2014.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:千葉   Country:Japan  

  31. 免疫シナプスを強化す免疫シナプスを強化するlenalidomideとEGFRvⅢキメラ抗原受容体発現T細胞の併用効果

    夏目敦至

    第32回日本脳腫瘍学会学術集会 

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    Event date: 2014.11 - 2014.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:千葉   Country:Japan  

  32. 髄膜腫の細胞増殖を制御するmechano-sensor としてのNF2関連遺伝子の機能

    夏目敦至

    第32回日本脳腫瘍学会学術集会 

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    Event date: 2014.11 - 2014.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  33. low grade gliomaにおける遺伝子変異の全貌

    夏目敦至

    第32回日本脳腫瘍学会学術集会 

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    Event date: 2014.11 - 2014.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  34. Epigentic plasticity and mutational landscapes reveal intratumoral heterogeneity and clonal evolutions in gliomas

    3rd Cancer Stem Cell Symposium 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  35. COG0911 INTEGRA study : a randomized screening phase II trial of chemoradiotherapy with interferon-b plus temozolomide versus chemoradiotherapy with temozolomide alone for newly-diagnosed glioblastoma International conference

    Natsume A

    Society for Neuro-Oncology 

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    Event date: 2014.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  36. 日本におけるTSC標準治療を目指して

    夏目敦至

    TSC Days Japan 2014 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  37. 膠芽腫ガイドラインにおけるギリアデルなどの位置づけ

    夏目敦至

    ギリアデル meet the expert 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  38. グリオーマのゲノム、エピゲノムの進展と悪性化のメカニズムと治療介入

    夏目敦至

    第3回島根脳腫瘍学術講演会 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  39. Intraoperative image-guided glioma surgery International conference

    Natsume A,

    The 4th Russia- Japan Neurosurgical Symposium 

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    Event date: 2014.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  40. Long-term survival in patients with primary intracranial germ cell tumors treated with International conference

    Natsume A

    15th European Congress of Neurosurgery(EANS 2014) 

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    Event date: 2014.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  41. KPSが低い再発悪性GliomaにおけるBevacizumabの有効性

    夏目敦至

    日本脳神経外科学会第73 回学術総会 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  42. JCOG0911 INTEGRA study : a randomized screening phase II trial of chemoradiotherapy with interferon- β plus temozolomide versus chemoradiotherapy with temozolomide alone for newlydiagnosed glioblastoma

    Natsume A

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    Event date: 2014.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  43. グリオーマ治療における覚醒下手術 intraoperative MRI を駆使した外科的摘出術の意義

    夏目敦至

    日本脳神経外科学会第73 回学術総会 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  44. 頭蓋咽頭腫に対する根治的摘出と機能温存の選択

    夏目敦至

    日本脳神経外科学会第73 回学術総会 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  45. 全エクソンシークエンスを用いたlow gradegliomaにおけるクローン進化の解析

    夏目敦至

    日本脳神経外科学会第73 回学術総会 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  46. GBMに対するPodoplanin特異的キメラ抗原受容体を発現するT細胞の抗腫瘍効果の検討

    夏目敦至

    日本脳神経外科学会第73 回学術総会 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  47. 合併キアリ奇形の治療戦略について

    夏目敦至

    日本脳神経外科学会第73 回学術総会 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  48. BCNU脳内留置用剤(Gliadel wafer)留置後の再発症例の検討

    夏目敦至

    日本脳神経外科学会第73 回学術総会 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  49. 低悪性度神経膠腫における全エクソーム解析

    夏目敦至

    第73回日本癌学会学術総会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  50. 脳腫瘍に対する臨床試験デザイン

    夏目敦至

    第3回Neuro-Oncology West 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  51. 膠芽腫ガイドラインの目的と推奨レベルの設定根拠

    夏目敦至

    脳腫瘍診療ガイドラインを考える会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  52. BCNU脳内留置用剤(Gliadel wafer)留置後の再発症例の検討

    夏目敦至

    第19回日本脳腫瘍の外科学会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  53. 覚醒下手術、intraoperative MRIを統合させたgrade II/IIIグリオーマに対する手術戦略

    夏目敦至

    第19回日本脳腫瘍の外科学会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  54. 覚醒下機能マッピングによる、書字・音読に関わる白質線維・dorsal inferior frontooccipital fasciculus(IFOF)の同定

    夏目敦至

    第12回日本Awake Surgery 学会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  55. 脳腫瘍の基礎と臨床

    夏目敦至

    中外製薬 富士御殿場研究所 研修会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:御殿場   Country:Japan  

  56. 低悪性度神経膠腫における全エクソーム解析

    夏目敦至

    平成26年度がん若手研究者ワークショップ 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:茅野   Country:Japan  

  57. 網羅的(エピ)ゲノム解析に基づく治療戦略

    夏目敦至

    第52回日本癌治療学会学術集会 

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    Event date: 2014.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  58. Temporal and spatial evolution of clones in low grade gliomas International conference

    Natsume A

    20th International Conference of Brain Tumor Research and Therapy 

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    Event date: 2014.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  59. Skull base brain tumor surgery navigation system based on updating preoperative images using positional information of surgical tools International conference

    Natsume A

    International conference on brain tumor research and therapy(ICBTRT) 

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    Event date: 2014.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  60. Vaccine-based immunotherapy for malignant gliomas-current trends and future perspectives International conference

    Natsume A

    SymBioPharma 

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    Event date: 2014.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  61. 脊髄損傷後急性期における自己免疫性炎症発生メカニズムの解明

    夏目敦至

    第29回日本脊髄外科学会 

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    Event date: 2014.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  62. Whole exome sequencing reveals the landscape of gene mutations and evolution in low-grade glioma International conference

    Natsume A

    AACR Annual Meeting 2014 

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    Event date: 2014.4

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  63. Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts International conference

    Natsume A

    AACR Annual Meeting 2014 

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    Event date: 2014.4

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  64. Engineering T-cells Expressing the Podoplanin Specific Chimeric Antigen Receptors

    Natsume A

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    Event date: 2014.2

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  65. 頭蓋内原発Atypical Teratoid/Rhabdoid Tumor(AT/RT) の特徴所見

    夏目敦至

    第31回日本脳腫瘍学会学術集会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:宮崎   Country:Japan  

  66. 膠芽腫関連homeoboxのcell biology

    夏目敦至

    第31回日本脳腫瘍学会学術集会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:宮崎   Country:Japan  

  67. Gliomaに対するEGFRvⅢキメラ抗原受容体発現T細胞療法とlenalidomide併用による効果

    夏目敦至

    第31回日本脳腫瘍学会学術集会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮崎   Country:Japan  

  68. GBMに対する化学療法による低免疫環境に耐性を持つ遺伝子改変T細胞療法の開発

    夏目敦至

    第31回日本脳腫瘍学会学術集会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮崎   Country:Japan  

  69. 膠芽腫の発生・進展におけるゲノム異常から誘導されるエピゲノム異常の同定

    夏目敦至

    第31回日本脳腫瘍学会学術集会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮崎   Country:Japan  

  70. 免疫染色による悪性神経膠腫のpseudoprogression予測法の開発

    夏目敦至

    第31回日本脳腫瘍学会学術集会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:宮崎   Country:Japan  

  71. Low grade gliomaにおける放射線療法の臨床意義

    夏目敦至

    第31回日本脳腫瘍学会学術集会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:宮崎   Country:Japan  

  72. 膠芽腫細胞におけるinterferon-betaの未分化性抑制効果

    夏目敦至

    第31回日本脳腫瘍学会学術集会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:宮崎   Country:Japan  

  73. 次世代医療機器ナビゲーション下経頭蓋磁気刺激(nTMS)システムによる新たな脳機能マッピング法の確立

    夏目敦至

    第31回日本脳腫瘍学会学術集会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮崎   Country:Japan  

  74. 非小細胞肺癌原発巣と脳転移巣におけるプロテオーム解析及び候補タンパクのvalidation

    夏目敦至

    第31回日本脳腫瘍学会学術集会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:宮崎   Country:Japan  

  75. ラマン分光装置による浸潤性グリオーマの術中診断への応用

    夏目敦至

    第31回日本脳腫瘍学会学術集会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:宮崎   Country:Japan  

  76. low grade gliomaにおける次世代全エクソンシークエンス

    夏目敦至

    第31回日本脳腫瘍学会学術集会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮崎   Country:Japan  

  77. Podoplaninに対するキメラ抗原受容体を発現させたT細胞の作製

    夏目敦至

    第31回日本脳腫瘍学会学術集会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:宮崎   Country:Japan  

  78. 神経膠腫から二次性膠芽腫への進展に関するゲノム異常とエピゲノム異常とメタボローム異常とのクロストーク

    夏目敦至

    日本脳神経外科学会第72 回学術総会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  79. 遺伝子解析と病理診断に基づく新たな脳腫瘍分類の展望

    夏目敦至

    日本脳神経外科学会第72 回学術総会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  80. ナビゲーション下経頭蓋磁気刺激法(nTMS)と覚醒下機能マッピング・モニタリングの融合̶functional MRIとnTMSの比較検討

    夏目敦至

    日本脳神経外科学会第72 回学術総会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  81. 非小細胞肺癌原発巣と脳転移巣におけるプロテオーム解析-候補タンパクのvalidation-

    夏目敦至

    日本脳神経外科学会第72 回学術総会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  82. ラマン分光装置による浸潤性グリオーマの術中診断への応用

    夏目敦至

    日本脳神経外科学会第72 回学術総会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  83. Podoplaninに対するキメラ抗原受容体を発現させたT細胞の作製

    夏目敦至

    日本脳神経外科学会第72 回学術総会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  84. 頭蓋内原発Atypical Teratoid/Rhabdoid Tumor(AT/RT) の画像診断~自験6例から

    夏目敦至

    日本脳神経外科学会第72 回学術総会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  85. Gliomaに対するEGFRvⅢキメラ抗原受容体発現T細胞療法とlenalidomide併用による効果

    夏目敦至

    日本脳神経外科学会第72 回学術総会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  86. EGFRvIII 特異的キメラ抗原レセプターを発現するT細胞へのmiR-17-92遺伝子導入はマウスGBMモデルにおいて抗腫瘍活性を増強させる

    夏目敦至

    日本脳神経外科学会第72 回学術総会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  87. Whole genome/exome sequencing reveal genetic basis of low grade glioma

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  88. 神経膠腫における全ゲノム/エクソーム解析

    夏目敦至

    第72回日本癌学会学術総会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  89. BCNU waferをeloquent areaに留置すべきか?̶BCNU waferを留置した中心前回及び錐体路直上に症候性脳浮腫が遷延した症例についての検討̶

    夏目敦至

    第85回日本脳神経外科学会中部支部学術集会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長久手 (愛知)   Country:Japan  

  90. glioma

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  91. 悪性グリオーマに対する化学療法の適正使用とガイドライン

    夏目敦至

    第85回日本脳神経外科学会中部支部会学術総会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知   Country:Japan  

  92. バイオロジーに基づいたグリオーマの摘出

    夏目敦至

    第18回日本脳腫瘍の外科学会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:滋賀   Country:Japan  

  93. 頭頂葉・神経膠腫における覚醒下機能マッピング・モニタリング

    夏目敦至

    第18回日本脳腫瘍の外科学会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大津   Country:Japan  

  94. 覚醒下機能マッピング・モニタリングを駆使した左頭頂葉腫瘍への挑戦

    夏目敦至

    第37回日本神経心理学会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  95. 覚醒下手術・皮質下マッピングによる書字・音読に関わる白質線維の同定

    夏目敦至

    第11回日本Awake Surgery 研究会 

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    Event date: 2013.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  96. 診断に難渋したAtypical Teratoid / Rhabdoid Tumor (AT/RT) の自験例

    夏目敦至

    第41回日本小児神経外科学会 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪   Country:Japan  

  97. 当施設における水頭症キャリーオーバーの特徴について

    夏目敦至

    第41回日本小児神経外科学会 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  98. 術中MRI 導入後のLow grade gliomaの成績

    夏目敦至

    第31回日本脳腫瘍病理学会 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  99. WHO grade II diffuse astrocytomasにおけるPDGFRA / MET gainの腫瘍内不均一性

    夏目敦至

    第31回日本脳腫瘍病理学会 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  100. 静注テモゾロミドの利便性とテモゾロミド耐性リンパ球内microRNA

    夏目敦至

    大分脳腫瘍研究会 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大分   Country:Japan  

  101. 脳腫瘍のエピジェネティクス異常と治療感受性

    夏目敦至

    第33回日本脳神経外科コングレス総会 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  102. テモダール療法からみたイメンドの有用性

    夏目敦至

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    Event date: 2013.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  103. 悪性脳腫瘍細胞のヒエラルキーとエピゲノム変化

    夏目敦至

    脳腫瘍学術講演会 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  104. 癌が運動野、言語野の近くに転移したらどうしますか

    夏目敦至

    癌の中枢神経合併症フォーラム2013 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:三島   Country:Japan  

  105. IDH1変異のある悪性脳腫瘍のメタボローム解析

    夏目敦至

    がんと代謝シンポジウム 

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    Event date: 2013.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  106. Whole Exome SequenceによるLow Grade Glioma のsubcloneからの悪性化の解析

    第30回日本脳腫瘍学会学術集会 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:広島   Country:Japan  

  107. Adoptive transfer of chimeric antigen receptor and miR-17/92-transfected T-cells

    Natsume A

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    Event date: 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  108. 免疫組織染色解析に基づく新たな初発膠芽腫のサブタイプ分類と層別化治療への展望

    夏目敦至

    第30回日本脳腫瘍学会学術集会 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:広島   Country:Japan  

  109. Low grade glioma の手術戦略 ─腫瘍制御と機能予後─

    夏目敦至

    第30回日本脳腫瘍学会学術集会 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:広島   Country:Japan  

  110. 膠芽腫細胞の可塑性とエピジェネティクス変化

    夏目敦至

    第30回日本脳腫瘍学会学術集会 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島   Country:Japan  

  111. マウスモデルを用いた神経膠腫における網羅的なエピゲノム解析とその意義の検討

    夏目敦至

    第30回日本脳腫瘍学会学術集会 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島   Country:Japan  

  112. 術中MRI時代のlow grade glioma に対する手術戦略

    夏目敦至

    第71回日本脳神経外科学会学術総会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  113. 二次性膠芽腫マウスモデルを用いた神経膠腫の発生と進展に関わるエピジェネティクスメカニズムの解析

    夏目敦至

    第71回社団法人日本脳神経外科学会総会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  114. 下垂体腺腫のエクソーム解析

    夏目敦至

    第71回日本脳神経外科学会学術総会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪   Country:Japan  

  115. Immunotherapy using gene-modified T-cells expressing chimeric antigen receptors specific to glioma that express EGFRvIII

    Natsume A

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  116. 脳腫瘍幹細胞を標的としたエピジェネティクス治療薬の創薬開発

    夏目敦至

    第71回日本脳神経外科学会学術総会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  117. 中枢神経悪性リンパ腫の治療成績と予後因子,眼球内リンパ腫の検討

    夏目敦至

    第71回日本脳神経外科学会学術総会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪   Country:Japan  

  118. Immunotherapy using gene-modified T-cells expressing chimeric antigen receptors specific to tumor-associated antigens

    Natsume A

     More details

    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  119. c-Myc induced medulloblastoma mouse models by using the RCAS/tv-a system

    Natsume A

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  120. 膠芽腫マウスモデルを用いたp53, Nf1欠失から引き起こされるエピジェネティクス異常の解析

    夏目敦至

    第71回日本癌学会学術総会 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  121. On the intratumoral heterogeneity underlying progression and/or chemoresistance of low-grade gliomas

    Natsume A

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    Event date: 2012.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  122. Intravenous administration of temozolomide as a useful alternative over oral treatment with temozolomide capsules in patients with gliomas International conference

    Natsume A

    Current Trend for Malignant glioma 

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    Event date: 2012.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  123. Epigenetics Plasticity and Clonal Evolutions in Glioblastoma International conference

    Natsume A

    NIH Seminar 

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    Event date: 2012.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  124. Epigenetic plasticity regulated by Polycomb Repressive Complex-mediated histone H3 lysine 27 trimethylation in human glioblastoma International conference

    Natsume A

    19th International Brain Tumor Research and Therapy Conference 

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    Event date: 2012.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  125. Interferon-beta and temozolomide combination therapy for malignant gliomas; phase I study and phase II clinicla study International conference

    Natsume A

    The 19 International Brain Tumor Research and Therapy Conference (Asilomar) 

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    Event date: 2012.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  126. The global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma International conference

    Natsume A

    10th International Conference of the Asian Clinical Oncology Society 

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    Event date: 2012.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  127. 先天性水頭症をきたし松果体腫瘍として発生したAT/RTの1例

    夏目敦至

    第30回日本脳腫瘍病理学会 

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    Event date: 2012.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  128. 大網弁とチタンメッシュによる頭蓋形成後に急速な腫瘍増大を来たした髄膜腫の一例

    夏目敦至

    第30回日本脳腫瘍病理学会 

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    Event date: 2012.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋   Country:Japan  

  129. The current status of image-guided neurosurgery for braintumors and its future perspective International conference

    Natsume A

    he 4th International Symposium of Brain Tumor Pathology 

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    Event date: 2012.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  130. Immunohistochemical analysis-based subclassification of gliomas with integrated genomic and epigenetic profile International conference

    Natsume A

    Asian Society of Neuro-Oncology 

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    Event date: 2012.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  131. Clinical significance of anti-mutated IDH1 antibodies International conference

    Natsume A

    Asian Society of Neuro-Oncology 

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    Event date: 2012.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  132. 髄芽腫再発例に対する新たな治療法の試み

    夏目敦至

    第2回京大・名大合同 駿河・遠江・東三河地区 脳神経外科カンファランス 

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    Event date: 2012.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:浜松   Country:Japan  

  133. Development of nano-medicine in the fields of neurosurgery International conference

    Natsume A

    The 5th International Symposium of Nanomedicine 

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    Event date: 2012.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  134. A functional analysis of HIF in the malignant meningioma

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    Event date: 2012.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  135. A functional analysis of HIF in the malignant meningioma

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    Event date: 2011.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  136. 悪性髄膜腫におけるDNAメチル化標的遺伝子HIFの機能解析

    夏目敦至

    平成23年神経皮膚症候群調査研究班成果報告 

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    Event date: 2011.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  137. 神経膠腫におけるmethylator phenotype の診断と予後に対する意義の検討

    夏目敦至

    第29回日本脳腫瘍学会学術総会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:下呂(岐阜)   Country:Japan  

  138. A functional analysis of HIF in the malignant meningioma

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  139. ヒト脳腫瘍の分子異常を反映したマウスモデルの開発

    夏目敦至

    第29回日本脳腫瘍学会学術総会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:下呂(岐阜)   Country:Japan  

  140. 頭蓋内teratomaの治療成績

    夏目敦至

    第29回日本脳腫瘍学会学術総会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:下呂(岐阜)   Country:Japan  

  141. 髄芽腫マウスモデルにおけるc-Mycアイソフォームの機能の比較

    夏目敦至

    第29回日本脳腫瘍学会学術総会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:下呂(岐阜)   Country:Japan  

  142. Gliomaにおける治療戦略

    夏目敦至

    鹿児島脳神経外科セミナー 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島   Country:Japan  

  143. Remote ischemic preconditioningによる神経幹細胞の酸化ストレスからの保護作用

    夏目敦至

    第12回日本分子脳神経外科学会総会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  144. 悪性髄膜腫におけるDNAメチル化標的遺伝子HOXとHIFの機能解析

    夏目敦至

    第70回日本脳神経外科学会総会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  145. 悪性脳腫瘍の抗がん剤耐性分子を標的とする核酸医薬のconvection-enhanced deliveryシステムと先駆的ロボティック手術を導入した統合的ナノテク先端医療の実用化

    夏目敦至

    第70回日本脳神経外科学会学術総会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  146. 代謝関連遺伝子IDH1変異を中心とした免疫組織染色解析に基づく初発膠芽腫のサブタイプ診断と個別化医療への展望

    夏目敦至

    第70回日本脳神経外科学会学術総会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  147. 放射線治療の強度を落とし晩期合併症の軽減を目指した大量化学療法による小児CNS embryonal tumorの治療成績

    夏目敦至

    第70回日本脳神経外科学会学術総会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  148. Glioblastotma治療に対する外科の役割 ─術中MRI導入前後の検討から見えてきたもの─

    夏目敦至

    第70回日本脳神経外科学会総会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  149. Neural stem cell-based interferon-b delivery reduces glial scar formation in spinal cord injury: A critical role for TLR-4

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  150. 頭蓋内teratomaの長期治療成績 33年間の症例を振り返って

    夏目敦至

    第70回日本脳神経外科学会総会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  151. ロボット技術に支援された次世代機能的定位脳手術

    夏目敦至

    第70回日本脳神経外科学会総会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  152. 迅速・低侵襲な脳腫瘍マウスモデルの作成法

    夏目敦至

    第70回日本脳神経外科学会総会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  153. 小脳上面のhemangioblastomaに対するoccipital transtentorial approachの有用性

    夏目敦至

    第70回日本脳神経外科学会総会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  154. Development of novel mouse models of medulloblastomas using the RCAS. tv-a gene transfer system

    Natsume A

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  155. LINE-1 methylation is directly proportional to MGMT promoter methylation and is a better prognostic factor for glioma

    Natsume A

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  156. グリオーマの化学療法オーバービュー

    夏目敦至

    第70回日本癌学会学術総会 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  157. 悪性脳腫瘍のエピジェネティクス異常

    夏目敦至

    ナノメディシンキックオフシンポジウム 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  158. Current trends in chemotherapy for glioblastoma multiforme

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  159. 悪性脳腫瘍のエピジェネティクス異常

    夏目敦至

    神奈川脳神経外科セミナー 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神奈川   Country:Japan  

  160. Immuno-therepay using retrovirally engineered T cells expressing chimeric antigen receptors specific to glioma-associated antigens International conference

    Natsume A

    2011 Japan Society of Gene Therapy Meeting 

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    Event date: 2011.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  161. Epigenetic alteration in glioma International conference

    Natsume A

    Korea Brain Tumor Society Meeting 

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    Event date: 2011.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  162. 術中MRI ─名古屋大学での経験─

    夏目敦至

    第11回日本術中画像情報学会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  163. 当施設におけるmini-open TLIFについて

    夏目敦至

    第26回日本脊髄外科学会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沼津   Country:Japan  

  164. 神経膠腫におけるジェネティクス,エピジェネティクスに基づく分子病理の解析

    夏目敦至

    第29回日本脳腫瘍病理学会 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  165. 膠芽腫における組織染色でのmIDH1など16マーカー発現とゲノム・エピゲノム解析によるsubtype分類と予後検討

    夏目敦至

    第29回日本脳腫瘍病理学会 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  166. 著明なpseudoprogressionを示した小児視床部悪性神経膠腫の一例

    夏目敦至

    第29回日本脳腫瘍病理学会 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  167. 膠芽腫における組織染色でのmIDH1など13マーカー発現とゲノム・エピゲノム解析によるsubtype分類と予後検討

    夏目敦至

    第29回日本脳腫瘍病理学会 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  168. 次世代型核酸医療の臨床応用への展開と展望

    夏目敦至

    脳腫瘍フォーラムin 名古屋 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  169. 当院におけるteratomaの治療成績

    夏目敦至

    第80回日本脳神経外科学会中部支部学術集会 

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    Event date: 2011.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:浜松   Country:Japan  

  170. 側頭葉内側腫瘍に対する手術戦略

    夏目敦至

    第3回東海脳腫瘍手術手技研究会 

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    Event date: 2011.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  171. 当施設のおける静注テモゾロミド療法の臨床経験

    夏目敦至

    東海脳腫瘍セミナー 

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    Event date: 2011.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  172. 悪性脳腫瘍の抗がん剤耐性分子を標的とする核酸医薬開発と先駆的ロボティック手術を導入した統合的ナノテク先端医療の実用化

    夏目敦至

    第7回ナノバイオフェア 

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    Event date: 2011.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  173. 抗がん剤耐性分子を標的とする核酸医薬開発

    夏目敦至

    第4回トランスレーショナル・クラブ 

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    Event date: 2010.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  174. Neural stem cell-based dual suicide gene delivery for matastatic brain tumors

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  175. IL13Rα 2を標的としたグリオーマに対する武装化T細胞療法の開発

    夏目敦至

    第28回日本脳腫瘍学会学術集会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢   Country:Japan  

  176. 膠芽腫におけるタンパク異常発現パターンの解析

    夏目敦至

    第28回日本脳腫瘍学会学術集会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢   Country:Japan  

  177. 初発膠芽腫に対する免疫組織染色を用いたGBM subtype analysisとその予後検討

    夏目敦至

    第28回日本脳腫瘍学会学術集会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢   Country:Japan  

  178. グリオーマ幹細胞におけるAkt結合蛋白Girdinによる幹細胞性の維持

    夏目敦至

    第28回日本脳腫瘍学会学術集会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢   Country:Japan  

  179. 髄芽腫・PNETの分子異常とマウスモデルの開発

    夏目敦至

    第28回日本脳腫瘍学会学術集会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢   Country:Japan  

  180. エピゲノムの見地からみた髄膜腫の再分類

    夏目敦至

    第28回日本脳腫瘍学会学術集会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢   Country:Japan  

  181. low grade gliomaの遺伝子解析と治療予後の検討

    夏目敦至

    第28回日本脳腫瘍学会学術集会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢   Country:Japan  

  182. 髄芽腫の発生機構解明とマウスモデルの開発

    夏目敦至

    第3回GCOE国内シンポジウム 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  183. The efficacy of interferon-β and temozolomide combination therapy for newly diagnosed primary

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  184. 名古屋大学におけるgrade 2 gliomaに対する手術・放射線・化学療法と治療予後についての検討

    夏目敦至

    第69回日本脳神経外科学会学術総会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  185. 初発膠芽腫に対するIFN-β +テモダール併用化学放射線療法のランダム化第2相試験

    夏目敦至

    第69回日本脳神経外科学会学術総会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  186. 小児のCNS embryonal tumorに対する末梢血幹細胞移植を用いた放射線化学療法の治療成績

    夏目敦至

    第69回日本脳神経外科学会学術総会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  187. 初発膠芽腫に対する免疫組織染色を用いたGBM subtype analysisとその予後検討

    夏目敦至

    第69回日本脳神経外科学会学術総会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  188. 統合的ゲノム・エピゲノム・プロテオーム解析による初発膠芽腫に対するテモゾロミド・インターフェロンβ 併用の有効性の評価

    夏目敦至

    第69回日本脳神経外科学会学術総会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  189. IFN遺伝子導入神経幹細胞による損傷脊髄機能回復

    夏目敦至

    第45回日本脊髄障害医学会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:松本   Country:Japan  

  190. Immuno-therepay using retrovirally engineered T cells expressing chimeric antigen receptors specific to glioma-associated antigens International conference

    Natsume A

    The 4th Indian Japanese Friendship Neurosurgicla Meeting 

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    Event date: 2010.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  191. 脳腫瘍の最新アトラス

    夏目敦至

    静岡がんセンター 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:静岡   Country:Japan  

  192. メチオニンPETとMRI-SWI画像が診断に有用であった基底核部germinomaの4例

    夏目敦至

    第79回日本脳神経外科学会中部支部学術集会 

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    Event date: 2010.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:松本   Country:Japan  

  193. The efficacy of interferon-β and temozolomide combination therapy for newly diagnosed primary

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    Event date: 2010.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  194. Akt の基質としてのGirdinの脳腫瘍幹細胞での維持の役割

    夏目敦至

    第69回日本癌学会学術総会 

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    Event date: 2010.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  195. A Multicenter Phase I Trial of Combination Therapy with Interferon-b and Temozolomide for High-grade Gliomas (INTEGRA study): The Final Report International conference

    Natsume A

    Asian society for clinical oncology 

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    Event date: 2010.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  196. 髄膜腫のエピゲノム解析

    夏目敦至

    第11回日本分子脳神経外科学会 

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    Event date: 2010.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台   Country:Japan  

  197. グリオーマ治療:発生の分子メカニズム解明からトランスレーショナルリサーチまで

    夏目敦至

    第11回日本分子脳神経外科学会 

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    Event date: 2010.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台   Country:Japan  

  198. グリオーマ幹細胞におけるAkt結合蛋白Girdinの役割とその腫瘍形成,分化,浸潤への影響

    夏目敦至

    第11回日本分子脳神経外科学会 

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    Event date: 2010.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台   Country:Japan  

  199. 東海脳腫瘍セミナーの今後

    夏目敦至

    東海脳腫瘍セミナー 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  200. 小児脳腫瘍とは

    夏目敦至

    キャンサーネットワークジャパン 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  201. Immuno-therepay using retrovirally engineered T cells expressing chimeric antigen receptors specific to glioma-associated antigens International conference

    Natsume A

    Japan Society of Gene Therapy 

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    Event date: 2010.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  202. Immunotherapy using retrovirally engineered T cell expressing chimeric antigen receptors specific

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    Event date: 2010.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  203. Epigenetic plasticity regulated by polycomb repressive complex in GBM-initiating cells International conference

    Natsume A

    Asian Society for Neurooncology 

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    Event date: 2010.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  204. The efficacy of interferon-R and temozolomide combination therapy for newly diagnosed primary glioblatoma:Multicenter study International conference

    Natsume A

    6th American Society of Clinical Oncology (ASCO) Annual Meeting 

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    Event date: 2010.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  205. Regulation of heterogeneity by Epigenetic modifications in GBM stem cells International conference

    Natsume A

    Memorial Sloan Kettering Cancer Center Seminar 

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    Event date: 2010.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  206. Gliomaの分子遺伝学の新展開

    夏目敦至

    脳腫瘍レビュー 

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    Event date: 2010.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  207. 先行する病変を有したgliosarcomaの一例

    夏目敦至

    第28回日本脳腫瘍病理学会 

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    Event date: 2010.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  208. EPIGENETIC PLASTICITY REGULATED BY POLYCOMB REPRESSIVE COMPLEX AS A MEDIATOR International conference

    Natsume A

    18th International Brain Tumor Conference 

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    Event date: 2010.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  209. テモダールをはじめとした化学療法の最新の治療成績と今後の展望

    夏目敦至

    第30回日本脳神経外科コングレス総会 

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    Event date: 2010.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  210. 言語機能の可視化と覚醒下手術

    夏目敦至

    東海脳腫瘍手術手技研究会 

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    Event date: 2010.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  211. Rhabdoid glioblastomaの一例

    夏目敦至

    第78回日本脳神経外科学会中部支部学術集会 

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    Event date: 2010.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  212. A clinical trial of interleukin-13 receptor alpha 2 peptide-pulsed DC vaccine for malignant gliomas International conference

    Natsume A

    World Congress of Vaccine 

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    Event date: 2010.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  213. 悪性神経膠腫に対する化学療法の最新知見

    夏目敦至

    名古屋neuro oncologyセミナー 

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    Event date: 2010.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  214. 悪性神経膠腫に対する化学療法の最新知見

    夏目敦至

    名古屋neuro oncologyセミナー 

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    Event date: 2010.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  215. A clinical trial of interleukin-13 receptor alpha 2 peptide-pulsed DC vaccine for malignant gliomas International conference

    Natsume A

    World Congress of Vaccine 

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    Event date: 2010.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  216. JCOG 0911「初発膠芽腫に対するインターフェロン–β+テモゾロミド併用療法のランダム化第Ⅱ相試験」の付随研究について

    夏目敦至

    JCOG脳腫瘍グループ合同班会議 

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    Event date: 2010.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  217. Glioblastoma subclasses defined by signal transduction pathway activity

    第2回NAGOYAグローバルリトリート 

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    Event date: 2010.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知   Country:Japan  

  218. 初発膠芽腫に対する遺伝子解析とIFN-β ,Temozolomide併用療法の功績

    夏目敦至

    第2回静岡県立がんセンターフロンティアセミナー 

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    Event date: 2010.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:静岡   Country:Japan  

  219. 初発膠芽腫に対するIFN-b+テモダールのretrospective study

    夏目敦至

    第4回東海脳腫瘍セミナー 

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    Event date: 2009.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  220. 膠芽腫の組織不均一性を制御するエピジェネティクス機構の解明と小分子化合物の開発

    夏目敦至

    第27回日本脳腫瘍学会 

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    Event date: 2009.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪(泉佐野)   Country:Japan  

  221. Epigenetic plasticity in gliomas International conference

    Natsume A

    Seoul National University 

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    Event date: 2009.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  222. グリオーマ幹細胞の多分化能を制御するポリコームタンパク郡の分子標的治療薬の開発

    夏目敦至

    第68回日本脳神経外科学会学術総会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  223. ポリコームタンパク郡を標的とした脳腫瘍幹細胞に対するエピジェネティクス治療の開発

    夏目敦至

    第68回日本癌学会学術総会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  224. エピジェネティクス解析とポリコーム蛋白標的治療の開発

    夏目敦至

    GCOE第2回国内シンポジウム 

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    Event date: 2009.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  225. Epigenetic plasticity in gliomas International conference

    Natume A

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    Event date: 2009.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  226. bench to bed side

    夏目敦至

    平成21年度鶴舞公開セミナー 

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    Event date: 2009.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  227. Interim analysis of combination chemoradiotherapy by means of temozolomide (TMZ) and interferon(IFN) beta for malignant glioma: multicenter clinical trial (INTEGRA study) International conference

    Natsume A

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    Event date: 2009.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  228. Epigenetic plasticity in gliomas International conference

    Natsume A

    UCSF 

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    Event date: 2009.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  229. INTEGRA study安全性試験中間報告

    夏目敦至

    第4回東海脳腫瘍セミナー 

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    Event date: 2009.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  230. A Japanese multicenter clinical trial of interferon-beta and temozolomide combination therapy for high grade gliomas: from bench to bedside International conference

    Natsume A

    The 17th international conference on brain tumor research andtherapy 

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    Event date: 2008.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  231. グリオーマ幹細胞の網羅的エピジェネティクス解析

    第66回日本脳神経外科学会総会 

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    Event date: 2007.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  232. Epigenetic target for cancer-testis antigen-based tumor immunotherapy

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    Event date: 2007.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  233. HDAC inhibitorとしてのバルプロ酸とDNAメチル化酵素阻害薬によるクロマチンリモデリング:グリオーマの癌精巣抗原の再活性化増強作用

    夏目敦至

    第8回日本分子脳神経外科学会 

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    Event date: 2007.8

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 8

  1. 難治性疾患等政策研究事業(分担):多彩な内分泌異常を生じる遺伝性疾患(多発性内分泌腫瘍症およびフォンヒッペル・リンドウ病)の実態把握と診療標準化の研究

    2016.4 - 2019.3

    科学技術振興調整費 

    櫻井 晃洋

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    Grant type:Competitive

  2. 次世代がん医療創生研究事業(分担):がん細胞の分化制御に関わるエピゲノムを標的とした革新的治療法の開発

    2016.4 - 2019.3

    次世代がん医療創生研究事業 

    近藤 豊

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    Grant type:Competitive

  3. 次世代がん医療創生研究事業(分担):TGF-βシグナル制御因子CD109を標的とした抗体治療薬の開発研究

    2016.4 - 2018.3

    次世代がん医療創生研究事業 

    高橋雅英

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    Grant type:Competitive

  4. 政策科学総合研究事業(分担):医療・介護連携を目指した"脳腫瘍ノート"の開発と、地域医療連携システム構築に関する研究

    2011.4 - 2013.3

    科学技術振興調整費 

    阿部竜也

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    Grant type:Competitive

  5. 難治性疾患克服研究事業(分担):フォン・ヒッペルリンドウ病の病態調査と診断治療系確立の研究

    2011.4 - 2012.3

    科学技術振興調整費 

    執印 太郎

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    Grant type:Competitive

  6. 脳腫瘍幹細胞(BTSC:Brain tumor stem cell)の同定・解析および分子標的としてのインターフェロンβの効果の検討

    2007

    第32回(平成19年度)がんその他の悪性新生物研究助成 

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    Grant type:Competitive

  7. 悪性脳腫瘍の新規アルキル化剤の耐性機構MGMTを効率的に不活化する分子標的薬剤のトランスレーショナルリサーチ

    2005 - 2006

    平成17年度 日本脳神経財団 学術研究助成 

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    Grant type:Competitive

  8. インターフェロンβによる新規アルキル化剤テモダールの感受性増強とDNA修復遺伝子MGMTの発現抑制

    2005

    第30回(平成17年度)がんその他の悪性新生物研究助成 

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 12

  1. 新学術領域(計画班代表):分子トレーシングを基盤としたがんと神経の細胞標的分子の創製

    2017.6 - 2022.3

    科学研究費補助金  新学術領域研究

    夏目敦至

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    Authorship:Principal investigator 

  2. 基盤B(代表):スーパーエンハンサーによる脳腫瘍の発生と悪性化のクロマチンダイナミクスの解明

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(B)

    夏目 敦至

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    Authorship:Principal investigator 

  3. 総括班(分担):ナノメディシン分子科学

    2013.4 - 2016.3

    科学研究費補助金  新学術領域研究

    石原一彦

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    Authorship:Coinvestigator(s) 

  4. 基盤B(代表):悪性脳腫瘍のヒエラルキーと可塑性の解析に基づくエピゲノム創薬

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(B)

    夏目敦至

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    Authorship:Principal investigator 

  5. 基盤A(分担):抗がん剤耐性分子を標的とする核酸医薬のロボティック送達とイメージングの統合医療

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(A)

    若林俊彦

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    Authorship:Coinvestigator(s) 

  6. 新学術領域(計画班代表):遺伝子解析と分子トレーシングを基盤とした細胞標的分子の創製

    2011.4 - 2016.3

    科学研究費補助金  新学術領域研究

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    Authorship:Principal investigator 

  7. 基盤B(分担)新規抗腫瘍効果判定を目指した分子標的イメージング診断薬の開発と臨床応用

    2009.4 - 2012.3

    科学研究費補助金  基盤研究(B)

    若林俊彦

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    Authorship:Principal investigator 

  8. 基盤C(分担)ポストゲノム時代における良性脳腫瘍のエピジェネティクス・バイオマーカーの開発

    2009.4 - 2011.3

    科学研究費補助金  基盤研究(C)

    斎藤 清

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    Authorship:Coinvestigator(s) 

  9. 基盤B(代表):悪性脳腫瘍の根治に向けたエピジェネティクスによるリプログラミング創薬の開発

    2009 - 2012.3

    科学研究費補助金  基盤研究(B)

    夏目 敦至

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    Authorship:Principal investigator 

  10. 基盤C(分担) ラット辺縁系てんかんモデルにおける細胞療法と併用した定位的脳深部刺激療法の開発

    2007.4 - 2009.3

    科学研究費補助金  基盤研究(C)

    梶田 泰一

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    Authorship:Coinvestigator(s) 

  11. 基盤C(代表):ポストゲノム時代における脳腫瘍のエピジェネティクス解析による診断・治療の新展開

    2007.4 - 2009.3

    科学研究費補助金  基盤研究(C)

    夏目 敦至

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    Authorship:Principal investigator 

  12. 若手B(代表)インターフェロンβによる中枢神経の機能再生の研究

    2004.4 - 2006.3

    科学研究費補助金  若手研究(B)

    夏目 敦至

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    Authorship:Principal investigator 

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Industrial property rights 1

  1. [2] 11C標識O6-ベンジルグアニン,O6-Methyl Guanine Methyl-Transferase活性を可視化可能なPETプローブ,及びそれらの製造方法

    鈴木正昭,伊藤健吾,池沼 宏,夏目敦至,古山浩子

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    Applicant:開発法人国立長寿医療研究センター,国立大学法人岐阜大学

    Application no:2016-134187  Date applied:2016.7

    Country of applicant:Domestic