Updated on 2022/10/27

写真a

 
SU Matthew paul
 
Organization
Institute for Advanced Research Designated assistant professor
Graduate School of Science Designated assistant professor
Title
Designated assistant professor

Degree 4

  1. PhD in Mechanosensory Biology （ 2017.2   University College London ） 

  2. MRes in Modelling Biological Complexity （ 2013.9   University College London ） 

  3. MSc in Modern Epidemiology, （ 2012.9   Imperial College London ） 

  4. MMath in Mathematics with Physics （ 2010.6   University of York ） 

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Research Interests 6

  1. Mosquitoes

  2. Hearing systems and behaviors

  3. Circadian clock

  4. Sex determination pathway

  5. Courtship

  6. Neuroscience

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Research History 5

  1. Nagoya University   IAR/Graduate School of Science   Associate Professor   YLC Designated Assistant Professor

    2021.6

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    Country：Japan

  2. Nagoya University   Graduate School of Science   Researcher   JSPS Research Fellow (Standard Fellowship)

    2020.10 - 2021.6

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    Country：Japan

  3. Nagoya University   Graduate School of Science   Researcher   Daiko-zaidan Research Fellow

    2020.3 - 2020.9

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    Country：Japan

  4. Nagoya University   Graduate School of Science   Researcher   JSPS Research Fellow (Short-term Fellowship)

    2019.8 - 2020.2

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    Country：Japan

  5. University College London   Ear Institute   PDRA   PDRA

    2017.1 - 2019.7

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    Country：United Kingdom

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Papers 25

  1. Acoustic Physiology in Mosquitoes.

    Su MP, Andrés M, Georgiades M, Bagi J, Albert JT

    Cold Spring Harbor protocols     2022.10

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    Language：English  

    DOI： 10.1101/pdb.top107685

    PubMed

  2. Electrophysiological Measurements of Compound Action Potential Responses from the Antennal Nerve in Response to Stimulation.

    Su MP, Albert JT

    Cold Spring Harbor protocols     2022.10

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    Language：English  

    DOI： 10.1101/pdb.prot108010

    PubMed

  3. Serotonin modulation in the male Aedes aegypti ear influences hearing

    Yifeng Y. J. Xu, YuMin M. Loh, Tai-Ting Lee, Takuro S. Ohashi, Matthew P. Su, Azusa Kamikouchi

    Frontiers in Physiology   Vol. 13   page： 931567   2022.8

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media SA  

    Male Aedes aegypti (Ae. aegypti) mosquitoes rely on hearing to identify conspecific females for mating, with the male attraction to the sound of flying females (“phonotaxis”) an important behavior in the initial courtship stage. Hearing thus represents a promising target for novel methods of mosquito control, and hearing behaviors (such as male phonotaxis) can be targeted via the use of sound traps. These traps unfortunately have proven to be relatively ineffective during field deployment. Shifting the target from hearing behavior to hearing function could therefore offer a novel method of interfering with Ae. aegypti mating. Numerous neurotransmitters, including serotonin (5-hydroxytryptamine, or 5-HT) and octopamine, are expressed in the male ear, with modulation of the latter proven to influence the mechanical responses of the ear to sound. The effect of serotonin modulation however remains underexplored despite its significant role in determining many key behaviors and biological processes of animals. Here we investigated the influence of serotonin on the Ae. aegypti hearing function and behaviors. Using immunohistochemistry, we found significant expression of serotonin in the male and female Ae. aegypti ears. In the male ear, presynaptic sites identified via antibody labelling showed only partial overlap with serotonin. Next, we used RT-qPCR to identify and quantify the expression levels of three different serotonin receptor families (5-HT<sub>1</sub>, 5-HT<sub>2</sub>, and 5-HT<sub>7</sub>) in the mosquito heads and ears. Although all receptors were identified in the ears of both sexes, those from the 5-HT<sub>7</sub> family were significantly more expressed in the ears relative to the heads. We then thoracically injected serotonin-related compounds into the mosquitoes and found a significant, reversible effect of serotonin exposure on the male ear mechanical tuning frequency. Finally, oral administration of a serotonin-synthesis inhibitor altered male phonotaxis. The mosquito serotonergic system and its receptors thus represent interesting targets for novel methods of mosquito, and thus disease, control.

    DOI： 10.3389/fphys.2022.931567

    Web of Science

    PubMed

  4. A novel beta-adrenergic like octopamine receptor modulates the audition of malaria mosquitoes and serves as insecticide target

    Marcos Georgiades, Chantif Alexandros Alampounti, Jason Somers, Matthew Su, David Ellis, Judit Bagi, Watson Ntabaliba, Sarah J Moore, Joerg T Albert, Marta Andres

        2022.8

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    Publisher：Cold Spring Harbor Laboratory  

    Hearing is an essential sense in the life cycle of malaria mosquitoes. Within large swarms formed transiently at dusk, mosquitoes acoustically recognize their mating partners by their wingbeats. Indeed, malaria mosquitoes only respond to the flight tones of mating partners during swarm time. This phenomenon implies a sophisticated context- and time-dependent modulation of mosquito audition, the mechanisms of which are still largely unknown. Using transcriptomics, we identify a complex network of candidate neuromodulators regulating mosquito hearing. Among them, octopamine stands out as regulator of the auditory performance during swarm time. To explore octopamine roles in mosquito hearing, we carried out an in-depth analysis of octopamine-mediated effects on auditory function. We found that octopamine affects the properties of the mosquito ear on multiple levels: it modulates the tuning and stiffness of the flagellar sound receiver and it controls the erection of antennal fibrillae in males. We found that two different receptors are driving octopamine auditory roles, including a novel beta octopamine receptor. We also demonstrate that the octopaminergic auditory control system can be targeted by insecticides. Our findings identify octopamine signalling as a key component of hearing and mating partner detection in malaria mosquitoes, and as a potential novel target for mosquito control.

    DOI： 10.1101/2022.08.02.502538

  5. Prohemocytes are the main cells infected by dengue virus in Aedes aegypti and Aedes albopictus

    Lie Cheng, Wei-Liang Liu, Matthew P. Su, Shu-Chen Huang, Jen-Ren Wang, Chun-Hong Chen

    Parasites & Vectors   Vol. 15 ( 1 ) page： 137   2022.4

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Background

    The primary disease vectors for dengue virus (DENV) transmission between humans are the mosquitoes Aedes aegypti and Aedes albopictus, with Ae. aegypti population size strongly correlated with DENV outbreaks. When a mosquito is infected with DENV, the virus migrates from the midgut to the salivary glands to complete the transmission cycle. How the virus crosses the hemocoel, resulting in systemic infection, is still unclear however. During viral infection and migration, the innate immune system is activated in defense. As part of cellular-mediated immunity, hemocytes are known to defend against bacteria and Plasmodium infection and may also participate in defending against DENV infection. Hemocytes are categorized into three cell types: prohemocytes, granulocytes, and oenocytoids. Here, we investigated which hemocytes can be infected by DENV and compare hemocyte infection between Ae. aegypti and Ae. albopictus.

    Methods

    Hemocytes were collected from Ae. aegypti and Ae. albopictus mosquitoes that were intrathoracically infected with DENV2-GFP. The collected hemocytes were then identified via Giemsa staining and examined microscopically for morphological differences and viral infection.

    Results

    All three types of hemocytes were infected by DENV, though the predominantly infected cell type was prohemocytes. In Ae. aegypti, the highest and lowest infection rates at 7 days post infection occurred in prohemocytes and granulocytes, respectively. Prohemocytes were also the primary infection target of DENV in Ae. albopictus, with similar infection rates across the other two hemocyte groups. The ratios of hemocyte composition did not differ significantly between non-infected and infected mosquitoes for either species.

    Conclusions

    In this study, we showed that prohemocytes were the major type of hemocyte infected by DENV in both Ae. aegypti and Ae. albopictus. The infection rate of prohemocytes in Ae. albopictus was lower than that in Ae. aegypti, which may explain why systemic DENV infection in Ae. albopictus is less efficient than in Ae. aegypti and why Ae. albopictus is less correlated to dengue fever outbreaks. Future work in understanding the mechanisms behind these phenomena may help reduce arbovirus infection prevalence.

    Graphical Abstract

    DOI： 10.1186/s13071-022-05276-w

    Web of Science

    PubMed

    Other Link： https://link.springer.com/article/10.1186/s13071-022-05276-w/fulltext.html

  6. Comparison of Fan-traps and Gravitraps for Aedes Mosquito Surveillance in Taiwan Reviewed

    Pan CP*, Cheng L*, Liu WL, Su Matthew P, Ho HP, Liao CH, Chang JH, Yang YC, Hsu CC, Huang JJ, Chen CH

    Frontiers in Public Health     2022.3

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    Language：English  

    DOI： 10.3389/fpubh.2022.778736

  7. Early Health Economic Modelling of Novel Therapeutics in Age-Related Hearing Loss Reviewed

    Landry EC, Scholte M, Su Matthew P, Horstink Y, Mandavia R, Rovers M, Schilder AGM

    Frontiers in Neuroscience     2022.3

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    Language：English  

    DOI： 10.3389/fnins.2022.769983

  8. Hitting the right note at the right time: Circadian control of audibility in Anopheles mosquito mating swarms is mediated by flight tones Reviewed

    Somers J, Georgiades M, Su Matthew P, Bagi J, Andrés M, Alampounti A, Mills G, Ntabaliba W, Moore SJ, Spaccapelo R, Albert JT

    Science Advances   Vol. 8 ( 2 )   2022.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1126/sciadv.abl4844

  9. Lab-scale characterization and semi-field trials of Wolbachia Strain wAlbB in a Taiwan Wolbachia introgressed Ae. aegypti strain Reviewed International coauthorship

    Liu WL*, Yu HY*, Chen YX, Chen BY, Leaw SN, Lin CH, Su Matthew P, Tsai LS, Chen Y, Shiao SH, Xi ZY, Jang ACC, Chen CH

    PLOS Neglected Tropical Diseases   Vol. 16 ( 1 )   2022.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pntd.0010084

  10. Transgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus

    Liu Wei-Liang, Hsu Chia-Wei, Chan Shih-Peng, Yen Pei-Shi, Su Matthew P., Li Jian-Chiuan, Li Hsing-Han, Cheng Lie, Tang Cheng-Kang, Ko Shih-Hsun, Tsai Huai-Kuang, Tsai Zing Tsung-Yeh, Akbari Omar S., Failoux Anna-Bella, Chen Chun-Hong

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page： 23865   2021.12

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  11. Generating mutant Aedes aegypti mosquitoes using the CRISPR/Cas9 system.

    Li HH, Li JC, Su MP, Liu KL, Chen CH

    STAR protocols   Vol. 2 ( 2 ) page： 100432   2021.6

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    Language：English  

    DOI： 10.1016/j.xpro.2021.100432

    PubMed

  12. Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila

    Lee Tai-Ting, Chen Po-Lin, Su Matthew P., Li Jian-Chiuan, Chang Yi-Wen, Liu Rei-Wen, Juan Hsueh-Fen, Yang Jinn-Moon, Chan Shih-Peng, Tsai Yu-Chen, von Stockum Sophia, Ziviani Elena, Kamikouchi Azusa, Wang Horng-Dar, Chen Chun-Hong

    AGING CELL   Vol. 20 ( 6 ) page： e13379   2021.6

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  13. Transgenic Expression of Human C-Type Lectin Protein CLEC18A Reduces Dengue Virus Type 2 Infectivity in Aedes aegypti

    Cheng L, Liu WL, Tsou YT, Li JC, Chien CH, Su MP, Liu KL, Huang YL, Wu SC, Tsai JJ, Hsieh SL, Chen CH

    Frontiers in immunology   Vol. 12   page： 640367   2021

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    Language：English  

    DOI： 10.3389/fimmu.2021.640367

    PubMed

  14. Assessing the acoustic behaviour of Anopheles gambiae (s.l.) dsxF mutants: implications for vector control

    Su Matthew P., Georgiades Marcos, Bagi Judit, Kyrou Kyros, Crisanti Andrea, Albert Joerg T.

    PARASITES & VECTORS   Vol. 13 ( 1 ) page： 507   2020.10

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  15. Releasing Intracellular NS1 from Mosquito Cells for the Detection of Dengue Virus-Infected Mosquitoes

    Cheng Lie, Liu Wei-Liang, Li Hsing-Han, Su Matthew P., Wu Shih-Cheng, Chen Hsin-Wei, Pan Chao-Ying, Tsai Jih-Jin, Chen Chun-Hong

    VIRUSES-BASEL   Vol. 12 ( 10 )   2020.10

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  16. C-Type Lectins Link Immunological and Reproductive Processes in Aedes aegypti

    Li Hsing-Han, Cai Yu, Li Jian-Chiuan, Su Matthew P., Liu Wei-Liang, Cheng Lie, Chou Shu-Jen, Yu Guann-Yi, Wang Horng-Dar, Chen Chun-Hong

    ISCIENCE   Vol. 23 ( 9 ) page： 101486   2020.9

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  17. Buzzkill: targeting the mosquito auditory system

    Andres Marta, Su Matthew P., Albert Joerg, Cator Lauren J.

    CURRENT OPINION IN INSECT SCIENCE   Vol. 40   page： 11 - 17   2020.8

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  18. Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster

    Chen Po-Lin, Huang Kai-Ting, Cheng Chu-Ya, Li Jian-Chiuan, Chan Hsiao-Yen, Lin Tzu-Yang, Su Matthew P., Yang Wei-Yuan, Chang Henry C., Wang Horng-Dar, Chen Chun-Hong

    NATURE COMMUNICATIONS   Vol. 11 ( 1 ) page： 2592   2020.5

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  19. Epidemiological analysis of the Kaohsiung city strategy for dengue fever quarantine and epidemic prevention

    Pan Chao-Ying, Liu Wei-Liang, Su Matthew-P, Chang Te-Pin, Ho Hui-Pin, Shu Pei-Yun, Huang Joh-Jong, Lin Li-Jen, Chen Chun-Hong

    BMC INFECTIOUS DISEASES   Vol. 20 ( 1 ) page： 347   2020.5

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  20. Local Delivery of Therapeutics to the Inner Ear: The State of the Science

    Anderson Caroline R., Xie Carol, Su Matthew P., Garcia Maria, Blackshaw Helen, Schilder Anne G. M.

    FRONTIERS IN CELLULAR NEUROSCIENCE   Vol. 13   page： 418   2019.10

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  21. Early phase trials of novel hearing therapeutics: Avenues and opportunities

    Schilder Anne G. M., Su Matthew P., Mandavia Rishi, Anderson Caroline R., Landry Evie, Ferdous Tanjinah, Blackshaw Helen

    HEARING RESEARCH   Vol. 380   page： 175 - 186   2019.9

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  22. Hearing Protection, Restoration, and Regeneration: An Overview of Emerging Therapeutics for Inner Ear and Central Hearing Disorders

    Schilder Anne G. M., Su Matthew P., Blackshaw Helen, Lustig Lawrence, Staecker Hinrich, Lenarz Thomas, Safieddine Saaid, Gomes-Santos Carina S., Holme Ralph, Warnecke Athanasia

    OTOLOGY & NEUROTOLOGY   Vol. 40 ( 5 ) page： 559 - 570   2019.6

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  23. Sex and species specific hearing mechanisms in mosquito flagellar ears.

    Su MP, Andrés M, Boyd-Gibbins N, Somers J, Albert JT

    Nature communications   Vol. 9 ( 1 ) page： 3911   2018.9

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    Language：English  

    DOI： 10.1038/s41467-018-06388-7

    PubMed

  24. Evolutionary changes in transcription factor coding sequence quantitatively alter sensory organ development and function.

    Weinberger S, Topping MP, Yan J, Claeys A, Geest N, Ozbay D, Hassan T, He X, Albert JT, Hassan BA, Ramaekers A

    eLife   Vol. 6   2017.4

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    Language：English  

    DOI： 10.7554/eLife.26402

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  25. A mechanosensory pathway to the Drosophila circadian clock.

    Simoni A, Wolfgang W, Topping MP, Kavlie RG, Stanewsky R, Albert JT

    Science (New York, N.Y.)   Vol. 343 ( 6170 ) page： 525 - 8   2014.1

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    Language：English  

    DOI： 10.1126/science.1245710

    PubMed

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