Updated on 2024/10/07

写真a

 
SU Matthew paul
 
Organization
Institute for Advanced Research Designated assistant professor
Graduate School of Science Designated assistant professor
Title
Designated assistant professor

Degree 4

  1. PhD in Mechanosensory Biology ( 2017.2   University College London ) 

  2. MRes in Modelling Biological Complexity ( 2013.9   University College London ) 

  3. MSc in Modern Epidemiology, ( 2012.9   Imperial College London ) 

  4. MMath in Mathematics with Physics ( 2010.6   University of York ) 

Research Interests 12

  1. Mosquitoes

  2. Hearing systems and behaviors

  3. Circadian clock

  4. Sex determination pathway

  5. Courtship

  6. Neuroscience

  7. Mosquitoes (Aedes, Anopheles, Culex)

  8. Mosquito swarming

  9. Mosquito acoustic behaviors

  10. Insect mechanosensory biology

  11. Insect hearing

  12. Circadian clock

Research History 5

  1. Nagoya University   IAR/Graduate School of Science   YLC Designated Assistant Professor   YLC Designated Assistant Professor

    2021.6

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    Country:Japan

  2. Nagoya University   Graduate School of Science   Researcher   JSPS Research Fellow (Standard Fellowship)

    2020.10 - 2021.6

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    Country:Japan

  3. Nagoya University   Graduate School of Science   Researcher   Daiko-zaidan Research Fellow

    2020.3 - 2020.9

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    Country:Japan

  4. Nagoya University   Graduate School of Science   Researcher   JSPS Research Fellow (Short-term Fellowship)

    2019.8 - 2020.2

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    Country:Japan

  5. University College London   Ear Institute   PDRA   PDRA

    2017.1 - 2019.7

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    Country:United Kingdom

Professional Memberships 1

  1. Japanese Neuroscience Society

 

Papers 35

  1. MACSFeD-a database of mosquito acoustic communication and swarming features. Reviewed International journal

    YuMin M Loh, Matthew P Su, Kayla G Haruni, Azusa Kamikouchi

    Database : the journal of biological databases and curation   Vol. 2024   2024.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Acoustic communication plays an important role during the courtship of many mosquito species. Male mosquitoes show strong attraction to female wing beat frequencies, mediated via spectral matching between female wing beat frequency and male ear mechanical tuning frequency. Such acoustic communication typically occurs within swarms, male-dominated aggregations with species-specific properties. Despite hundreds of relevant publications being available, the lack of a central platform hosting all associated data hinders research efforts and limits cross-species comparisons. Here, we introduce MACSFeD (Mosquito Acoustic Communication and Swarming Features Database), an interactive platform for the exploration of our comprehensive database containing 251 unique reports focusing on different aspects of mosquito acoustic communication, including hearing function, wing beat frequency and phonotaxis, as well as male swarming parameters. MACSFeD serves as an easily accessible, efficient, and robust data visualization tool for mosquito acoustic communication research. We envision that further in-depth studies could arise following the use of this new platform. Database URL: https://minmatt.shinyapps.io/MACSFeD/.

    DOI: 10.1093/database/baae086

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  2. Differences in male Aedes aegypti and Aedes albopictus hearing systems facilitate recognition of conspecific female flight tones Reviewed International coauthorship

    Yu Min M. Loh, Yifeng Y.J. Xu, Tai Ting Lee, Takuro S. Ohashi, Yixiao D. Zhang, Daniel F. Eberl, Matthew P. Su, Azusa Kamikouchi

    iScience   Vol. 27 ( 7 ) page: 110264   2024.7

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    When Aedes albopictus mosquitoes invade regions predominated by Aedes aegypti, either the latter can be displaced or the species can coexist, with potential consequences on disease transmission. Males from both species identify females by listening for her flight sounds. Comparing male hearing systems may provide insight into how hearing could prevent interspecific mating. Here, we show that species-specific differences in female wing beat frequencies are reflected in differences in male ear mechanical tuning frequencies and sound response profiles. Though Aedes albopictus males are attracted to sound, they do not readily display abdominal bending, unlike Aedes aegypti. We observed interspecific differences in male ear mechanical, but not electrical, tuning, suggesting a conserved primary auditory processing pathway. Our work suggests a potential role for hearing in the premating isolation of Aedes aegypti and Aedes albopictus, with implications for predicting future dynamics in their sympatric relationships and our understanding of mosquito acoustic communication.

    DOI: 10.1016/j.isci.2024.110264

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  3. Sexually dimorphic auditory representation inAedes aegyptibrains International coauthorship

    Takuro S. Ohashi, Yifeng Y.J. Xu, Shunsuke Shigaki, Yukiko Nakamura, Tai-Ting Lee, YuMin M. Loh, Emi Mishiro-Sato, Daniel F. Eberl, Matthew P. Su, Azusa Kamikouchi

    bioRxiv     2024.7

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    Authorship:Corresponding author  

    DOI: 10.1101/2024.07.07.602439

  4. Targeting Sex Determination to Suppress Mosquito Populations. Reviewed International coauthorship International journal

    eLife     2024.1

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    Language:English  

    DOI: 10.7554/eLife.90199.3

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  5. The voltage-gated potassium channelShal(Kv4) contributes to active hearing inDrosophila International coauthorship

    Eli S. Gregory, YiFeng Y. J. Xu, Tai-Ting Lee, Mei-ling A. Joiner, Azusa Kamikouchi, Matthew P. Su, Daniel F. Eberl

        2024.1

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  6. Mechanical transmission of dengue virus by Aedes aegypti may influence disease transmission dynamics during outbreaks. Reviewed International coauthorship

    Li HH, Su MP, Wu SC, Tsou HH, Chang MC, Cheng YC, Tsai KN, Wang HW, Chen GH, Tang CK, Chung PJ, Tsai WT, Huang LR, Yueh YA, Chen HW, Pan CY, Akbari OS, Chang HH, Yu GY, Marshall JM, Chen CH

    EBioMedicine   Vol. 94   page: 104723   2023.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ebiom.2023.104723

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  7. Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target Reviewed International coauthorship

    Georgiades Marcos, Alampounti Alexandros, Somers Jason, Su Matthew P. P., Ellis David A., Bagi Judit, Terrazas-Duque Daniela, Tytheridge Scott, Ntabaliba Watson, Moore Sarah, Albert Joerg T., Andres Marta

    NATURE COMMUNICATIONS   Vol. 14 ( 1 ) page: 4338   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-023-40029-y

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  8. Acoustic Communication in Fruit Flies and Mosquitoes

    Matthew P. Su, Azusa Kamikouchi

    Acoustic Communication in Animals     page: 27 - 45   2023.6

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    Authorship:Lead author   Publishing type:Part of collection (book)   Publisher:Springer Nature Singapore  

    DOI: 10.1007/978-981-99-0831-8_2

  9. Acoustic Physiology in Mosquitoes Reviewed International coauthorship

    Matthew P. Su, Marta Andrés, Marcos Georgiades, Judit Bagi, Joerg T. Albert

    Cold Spring Harbor Protocols   Vol. 2023 ( 4 ) page: pdb.top107685   2023.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Cold Spring Harbor Laboratory  

    The acoustic physiology of mosquitoes is perhaps the most complex within the entire insect class. Past research has uncovered several of its—sometimes stunningly unconventional—principles, but many mysteries remain. Their solution necessitates a concerted transdisciplinary effort to successfully link the neuroanatomical and biophysical properties of mosquito flagellar ears to the behavioral ecology of entire mosquito populations. Neuroanatomically, mosquito ears can rival those of humans in both complexity and sheer size. The approximately 16,000 auditory hair cells within the human organ of Corti, for example, are matched by the approximately 16,000 auditory neurons in the Johnston's organ of a maleAnophelesmosquito. Both human and mosquito ears receive very extensive efferent innervation, which modulates their function in ways that are as yet poorly understood. Different populations of neuronal and nonneuronal cell types divide the labor of the mosquito ear amongst themselves. Yet, what exactly this labor is, and how it is achieved, is at best vaguely known. For the majority of mosquitoes, biologically relevant sounds are inextricably linked to their flight tones. Either these flight tones are (directly) the sounds of interest or they contribute (indirectly) to the production of audible sound through a process called nonlinear distortion. Finally, male ears can generate tones themselves: The generation of an internal “phantom copy” of a female flight tone (orself-sustained oscillation) is believed to aid the male hearing process. Here, we introduce protocols that target the mosquitoes’ auditory neuroanatomy, electrophysiology, and behavior to help shed light on some of these issues.

    DOI: 10.1101/pdb.top107685

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  10. Electrophysiological Measurements of Compound Action Potential Responses from the Antennal Nerve in Response to Stimulation Reviewed International coauthorship

    Matthew P. Su, Joerg T. Albert

    Cold Spring Harbor Protocols   Vol. 2023 ( 4 ) page: pdb.prot108010   2023.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Cold Spring Harbor Laboratory  

    Electrophysiological recordings taken from the antennal nerve can provide essential information on the general auditory condition of the mosquito tested. Furthermore, electrophysiological recordings provide detailed information on what types of stimulation induce the largest nerve responses. When these are used in conjunction with a vibrometer to measure the corresponding movement of the antennal ear during stimulation, a comprehensive overview of hearing function can be obtained. This protocol can be applied to male and female adults from any mosquito strain and can be scaled relative to available resources.

    DOI: 10.1101/pdb.prot108010

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  11. The auditory efferent system in mosquitoes Reviewed International coauthorship

    Loh YuMin M., Su Matthew P., Ellis David A., Andres Marta

    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY   Vol. 11   page: 1123738   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fcell.2023.1123738

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  12. CLEC5A mediates Zika virus-induced testicular damage Reviewed International coauthorship

    Wang Hsin-Wei, Li Hsing-Han, Wu Shih-Cheng, Tang Cheng-Kang, Yu Hui-Ying, Chang Ya-Chen, Sung Pei-Shan, Liu Wei-Liang, Su Matthew P., Yu Guann-Yi, Huang Li-Rung, Chen Chun-Hong, Hsieh Shie-Liang

    JOURNAL OF BIOMEDICAL SCIENCE   Vol. 30 ( 1 ) page: 12   2023.2

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    DOI: 10.1186/s12929-023-00906-6

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  13. Evolutionary conservation and diversification of auditory neural circuits that process courtship songs in Drosophila Reviewed

    Takuro S. Ohashi, Yuki Ishikawa, Takeshi Awasaki, Matthew P. Su, Yusuke Yoneyama, Nao Morimoto, Azusa Kamikouchi

    Scientific Reports   Vol. 13 ( 1 ) page: 383   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Acoustic communication signals diversify even on short evolutionary time scales. To understand how the auditory system underlying acoustic communication could evolve, we conducted a systematic comparison of the early stages of the auditory neural circuit involved in song information processing between closely-related fruit-fly species. Male Drosophila melanogaster and D. simulans produce different sound signals during mating rituals, known as courtship songs. Female flies from these species selectively increase their receptivity when they hear songs with conspecific temporal patterns. Here, we firstly confirmed interspecific differences in temporal pattern preferences; D. simulans preferred pulse songs with longer intervals than D. melanogaster. Primary and secondary song-relay neurons, JO neurons and AMMC-B1 neurons, shared similar morphology and neurotransmitters between species. The temporal pattern preferences of AMMC-B1 neurons were also relatively similar between species, with slight but significant differences in their band-pass properties. Although the shift direction of the response property matched that of the behavior, these differences are not large enough to explain behavioral differences in song preferences. This study enhances our understanding of the conservation and diversification of the architecture of the early-stage neural circuit which processes acoustic communication signals.

    DOI: 10.1038/s41598-022-27349-7

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    Other Link: https://www.nature.com/articles/s41598-022-27349-7

  14. Serotonin modulation in the male Aedes aegypti ear influences hearing Reviewed

    Yifeng Y. J. Xu, YuMin M. Loh, Tai-Ting Lee, Takuro S. Ohashi, Matthew P. Su, Azusa Kamikouchi

    Frontiers in Physiology   Vol. 13   page: 931567   2022.8

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Frontiers Media SA  

    Male Aedes aegypti (Ae. aegypti) mosquitoes rely on hearing to identify conspecific females for mating, with the male attraction to the sound of flying females (“phonotaxis”) an important behavior in the initial courtship stage. Hearing thus represents a promising target for novel methods of mosquito control, and hearing behaviors (such as male phonotaxis) can be targeted via the use of sound traps. These traps unfortunately have proven to be relatively ineffective during field deployment. Shifting the target from hearing behavior to hearing function could therefore offer a novel method of interfering with Ae. aegypti mating. Numerous neurotransmitters, including serotonin (5-hydroxytryptamine, or 5-HT) and octopamine, are expressed in the male ear, with modulation of the latter proven to influence the mechanical responses of the ear to sound. The effect of serotonin modulation however remains underexplored despite its significant role in determining many key behaviors and biological processes of animals. Here we investigated the influence of serotonin on the Ae. aegypti hearing function and behaviors. Using immunohistochemistry, we found significant expression of serotonin in the male and female Ae. aegypti ears. In the male ear, presynaptic sites identified via antibody labelling showed only partial overlap with serotonin. Next, we used RT-qPCR to identify and quantify the expression levels of three different serotonin receptor families (5-HT<sub>1</sub>, 5-HT<sub>2</sub>, and 5-HT<sub>7</sub>) in the mosquito heads and ears. Although all receptors were identified in the ears of both sexes, those from the 5-HT<sub>7</sub> family were significantly more expressed in the ears relative to the heads. We then thoracically injected serotonin-related compounds into the mosquitoes and found a significant, reversible effect of serotonin exposure on the male ear mechanical tuning frequency. Finally, oral administration of a serotonin-synthesis inhibitor altered male phonotaxis. The mosquito serotonergic system and its receptors thus represent interesting targets for novel methods of mosquito, and thus disease, control.

    DOI: 10.3389/fphys.2022.931567

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  15. Prohemocytes are the main cells infected by dengue virus in Aedes aegypti and Aedes albopictus Reviewed International coauthorship

    Lie Cheng, Wei-Liang Liu, Matthew P. Su, Shu-Chen Huang, Jen-Ren Wang, Chun-Hong Chen

    Parasites & Vectors   Vol. 15 ( 1 ) page: 137   2022.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Background

    The primary disease vectors for dengue virus (DENV) transmission between humans are the mosquitoes Aedes aegypti and Aedes albopictus, with Ae. aegypti population size strongly correlated with DENV outbreaks. When a mosquito is infected with DENV, the virus migrates from the midgut to the salivary glands to complete the transmission cycle. How the virus crosses the hemocoel, resulting in systemic infection, is still unclear however. During viral infection and migration, the innate immune system is activated in defense. As part of cellular-mediated immunity, hemocytes are known to defend against bacteria and Plasmodium infection and may also participate in defending against DENV infection. Hemocytes are categorized into three cell types: prohemocytes, granulocytes, and oenocytoids. Here, we investigated which hemocytes can be infected by DENV and compare hemocyte infection between Ae. aegypti and Ae. albopictus.

    Methods

    Hemocytes were collected from Ae. aegypti and Ae. albopictus mosquitoes that were intrathoracically infected with DENV2-GFP. The collected hemocytes were then identified via Giemsa staining and examined microscopically for morphological differences and viral infection.

    Results

    All three types of hemocytes were infected by DENV, though the predominantly infected cell type was prohemocytes. In Ae. aegypti, the highest and lowest infection rates at 7 days post infection occurred in prohemocytes and granulocytes, respectively. Prohemocytes were also the primary infection target of DENV in Ae. albopictus, with similar infection rates across the other two hemocyte groups. The ratios of hemocyte composition did not differ significantly between non-infected and infected mosquitoes for either species.

    Conclusions

    In this study, we showed that prohemocytes were the major type of hemocyte infected by DENV in both Ae. aegypti and Ae. albopictus. The infection rate of prohemocytes in Ae. albopictus was lower than that in Ae. aegypti, which may explain why systemic DENV infection in Ae. albopictus is less efficient than in Ae. aegypti and why Ae. albopictus is less correlated to dengue fever outbreaks. Future work in understanding the mechanisms behind these phenomena may help reduce arbovirus infection prevalence.

    Graphical Abstract

    DOI: 10.1186/s13071-022-05276-w

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    Other Link: https://link.springer.com/article/10.1186/s13071-022-05276-w/fulltext.html

  16. Comparison of Fan-Traps and Gravitraps for Aedes Mosquito Surveillance in Taiwan Reviewed International coauthorship

    Chao-Ying Pan, Lie Cheng, Wei-Liang Liu, Matthew P. Su, Hui-Pin Ho, Che-Hun Liao, Jui-Hun Chang, Yu-Chieh Yang, Cheng-Chun Hsu, Joh-Jong Huang, Chun-Hong Chen

    Frontiers in Public Health   Vol. 10   page: 778736   2022.3

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    A key component of integrated vector management strategies is the efficient implementation of mosquito traps for surveillance and control. Numerous trap types have been created with distinct designs and capture mechanisms, but identification of the most effective trap type is critical for effective implementation. For dengue vector surveillance, previous studies have demonstrated that active traps utilizing CO<sub>2</sub> attractant are more effective than passive traps for capturing Aedes mosquitoes. However, maintaining CO<sub>2</sub> supply in traps is so labor intensive as to be likely unfeasible in crowded residential areas, and it is unclear how much more effective active traps lacking attractants are than purely passive traps. In this study, we analyzed Aedes capture data collected in 2019 from six urban areas in Kaohsiung City to compare Aedes mosquito catch rates between (passive) gravitraps and (active) fan-traps. The average gravitrap index (GI) and fan-trap index (FI) values were 0.68 and 3.39 respectively at peak catch times from June to August 2019, with consistently higher FI values calculated in all areas studied. We compared trap indices to reported cases of dengue fever and correlated them with weekly fluctuations in temperature and rainfall. We found that FI trends aligned more closely with case numbers and rainfall than GI values, supporting the use of fan-traps for Aedes mosquito surveillance and control as part of broader vector management strategies. Furthermore, combining fan-trap catch data with rapid testing for dengue infections may improve the early identification and prevention of future disease outbreaks.

    DOI: 10.3389/fpubh.2022.778736

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  17. Early Health Economic Modeling of Novel Therapeutics in Age-Related Hearing Loss Reviewed International coauthorship

    Evie C. Landry, Mirre Scholte, Matthew P. Su, Yvette Horstink, Rishi Mandavia, Maroeska M. Rovers, Anne G. M. Schilder

    Frontiers in Neuroscience   Vol. 16   page: 769983   2022.3

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    Background

    Health systems face challenges to accelerate access to innovations that add value and avoid those unlikely to do so. This is very timely to the field of age-related sensorineural hearing loss (ARHL), where a significant unmet market need has been identified and sizeable investments made to promote the development of novel hearing therapeutics (NT). This study aims to apply health economic modeling to inform the development of cost-effective NT.

    Methods

    We developed a decision-analytic model to assess the potential costs and effects of using regenerative NT in patients ≥50 with ARHL. This was compared to the current standard of care including hearing aids and cochlear implants. Input data was collected from systematic literature searches and expert opinion. A UK NHS healthcare perspective was adopted. Three different but related analyses were performed using probabilistic modeling: (1) headroom analysis, (2) scenario analyses, and (3) threshold analyses.

    Results

    The headroom analysis shows an incremental net monetary benefit (iNMB) of £20,017[£11,299–£28,737] compared to the standard of care due to quality-adjusted life-years (QALY) gains and cost savings. Higher therapeutic efficacy and access for patients with all degrees of hearing loss yields higher iNMBs. Threshold analyses shows that the ceiling price of the therapeutic increases with more severe degrees of hearing loss.

    Conclusion

    NT for ARHL are potentially cost-effective under current willingness-to-pay (WTP) thresholds with considerable room for improvement in the current standard of care pathway. Our model can be used to help decision makers decide which therapeutics represent value for money and are worth commissioning, thereby paving the way for urgently needed NT.

    DOI: 10.3389/fnins.2022.769983

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  18. Lab-scale characterization and semi-field trials of Wolbachia Strain wAlbB in a Taiwan Wolbachia introgressed Ae. aegypti strain Reviewed International coauthorship

    Wei-Liang Liu, Hui-Ying Yu, Yu-Xuan Chen, Bo-Yu Chen, Shiang Ning Leaw, Cheng-Han Lin, Matthew-P. Su, Ling-Shan Tsai, Yi Chen, Shin-Hong Shiao, Zhiyong Xi, Anna C-C Jang, Chun-Hong Chen

    PLOS Neglected Tropical Diseases   Vol. 16 ( 1 ) page: e0010084 - e0010084   2022.1

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    Dengue fever is one of the most severe viral diseases transmitted by Aedes mosquitoes, with traditional approaches of disease control proving insufficient to prevent significant disease burden. Release of Wolbachia-transinfected mosquitoes offers a promising alternative control methodologies; Wolbachia-transinfected female Aedes aegypti demonstrate reduced dengue virus transmission, whilst Wolbachia-transinfected males cause zygotic lethality when crossed with uninfected females, providing a method for suppressing mosquito populations. Although highly promising, the delicate nature of population control strategies and differences between local species populations means that controlled releases of Wolbachia-transinfected mosquitoes cannot be performed without extensive testing on specific local Ae. aegypti populations. In order to investigate the potential for using Wolbachia to suppress local Ae. aegypti populations in Taiwan, we performed lab-based and semi-field fitness trials. We first transinfected the Wolbachia strain wAlbB into a local Ae. aegypti population (wAlbB-Tw) and found no significant changes in lifespan, fecundity and fertility when compared to controls. In the laboratory, we found that as the proportion of released male mosquitoes carrying Wolbachia was increased, population suppression could reach up to 100%. Equivalent experiments in semi-field experiments found suppression rates of up to 70%. The release of different ratios of wAlbB-Tw males in the semi-field system provided an estimate of the optimal size of male releases. Our results indicate that wAlbB-Tw has significant potential for use in vector control strategies aimed at Ae. aegypti population suppression in Taiwan. Open field release trials are now necessary to confirm that wAlbB-Tw mediated suppression is feasible in natural environments.

    DOI: 10.1371/journal.pntd.0010084

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  19. Hitting the right note at the right time: Circadian control of audibility in <i>Anopheles</i> mosquito mating swarms is mediated by flight tones Reviewed International coauthorship

    Jason Somers, Marcos Georgiades, Matthew P. Su, Judit Bagi, Marta Andrés, Alexandros Alampounti, Gordon Mills, Watson Ntabaliba, Sarah J. Moore, Roberta Spaccapelo, Joerg T. Albert

    Science Advances   Vol. 8 ( 2 ) page: eabl4844   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Association for the Advancement of Science (AAAS)  

    By beating their wings faster around sunset, male Anopheles mosquitoes sensitize their auditory system to female flight tones.

    DOI: 10.1126/sciadv.abl4844

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  20. Transgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus Reviewed International coauthorship

    Wei-Liang Liu, Chia-Wei Hsu, Shih-Peng Chan, Pei-Shi Yen, Matthew P. Su, Jian-Chiuan Li, Hsing-Han Li, Lie Cheng, Cheng-Kang Tang, Shih-Hsun Ko, Huai-Kuang Tsai, Zing Tsung-Yeh Tsai, Omar S. Akbari, Anna-Bella Failloux, Chun-Hong Chen

    Scientific Reports   Vol. 11 ( 1 ) page: 23865   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    The areas where dengue virus (DENV) is endemic have expanded rapidly, driven in part by the global spread of Aedes species, which act as disease vectors. DENV replicates in the mosquito midgut and is disseminated to the mosquito’s salivary glands for amplification. Thus, blocking virus infection or replication in the tissues of the mosquito may be a viable strategy for reducing the incidence of DENV transmission to humans. Here we used the mariner Mos1 transposase to create an Aedes aegypti line that expresses virus-specific miRNA hairpins capable of blocking DENV replication. These microRNA are driven by the blood-meal-inducible carboxypeptidase A promoter or by the polyubiquitin promoter. The transgenic mosquitoes exhibited significantly lower infection rates and viral titers for most DENV serotypes 7 days after receiving an infectious blood meal. The treatment was also effective at day 14 post infection after a second blood meal had been administered. In viral transmission assay, we found there was significantly reduced transmission in these lines. These transgenic mosquitoes were effective in silencing most of the DENV genome; such an approach may be employed to control a dengue fever epidemic.

    DOI: 10.1038/s41598-021-03229-4

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    Other Link: https://www.nature.com/articles/s41598-021-03229-4

  21. Generating mutant Aedes aegypti mosquitoes using the CRISPR/Cas9 system

    Hsing-Han Li, Jian-Chiuan Li, Matthew P. Su, Kun-Lin Liu, Chun-Hong Chen

    STAR Protocols   Vol. 2 ( 2 ) page: 100432 - 100432   2021.6

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    DOI: 10.1016/j.xpro.2021.100432

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  22. Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila Reviewed International coauthorship International journal

    Tai-Ting Lee, Po-Lin Chen, Matthew P. Su, Jian-Chiuan Li, Yi-Wen Chang, Rei-Wen Liu, Hsueh-Fen Juan, Jinn-Moon Yang, Shih-Peng Chan, Yu-Chen Tsai, Sophia Stockum, Elena Ziviani, Azusa Kamikouchi, Horng-Dar Wang, Chun-Hong Chen

    Aging Cell   Vol. 20 ( 6 ) page: e13379   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Increased levels of dysfunctional mitochondria within skeletal muscle are correlated with numerous age-related physiopathological conditions. Improving our understanding of the links between mitochondrial function and muscle proteostasis, and the role played by individual genes and regulatory networks, is essential to develop treatments for these conditions. One potential player is the mitochondrial outer membrane protein Fis1, a crucial fission factor heavily involved in mitochondrial dynamics in yeast but with an unknown role in higher-order organisms. By using Drosophila melanogaster as a model, we explored the effect of Fis1 mutations generated by transposon Minos-mediated integration. Mutants exhibited a higher ratio of damaged mitochondria with age as well as elevated reactive oxygen species levels compared with controls. This caused an increase in oxidative stress, resulting in large accumulations of ubiquitinated proteins, accelerated muscle function decline, and mitochondrial myopathies in young mutant flies. Ectopic expression of Fis1 isoforms was sufficient to suppress this phenotype. Loss of Fis1 led to unbalanced mitochondrial proteostasis within fly muscle, decreasing both flight capabilities and lifespan. Fis1 thus clearly plays a role in fly mitochondrial dynamics. Further investigations into the detailed function of Fis1 are necessary for exploring how mitochondrial function correlates with muscle health during aging.

    DOI: 10.1111/acel.13379

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  23. Transgenic Expression of Human C-Type Lectin Protein CLEC18A Reduces Dengue Virus Type 2 Infectivity in Aedes aegypti Reviewed International coauthorship

    Matthew Su

    Frontiers in Immunology   Vol. 12   page: 640367   2021.3

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    DOI: 10.3389/fimmu.2021.640367

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  24. Assessing the acoustic behaviour of Anopheles gambiae s.l. dsxF mutants: Implications for Vector Control Reviewed International coauthorship

    Matthew P. Su, Marcos Georgiades, Judit Bagi, Kyros Kyrou, Andrea Crisanti, Joerg T. Albert

    Parasites & Vectors   Vol. 13 ( 1 ) page: 507   2020.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13071-020-04382-x

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  25. Releasing Intracellular NS1 from Mosquito Cells for the Detection of Dengue Virus-Infected Mosquitoes

    Lie Cheng, Wei-Liang Liu, Hsing-Han Li, Matthew P. Su, Shih-Cheng Wu, Hsin-Wei Chen, Chao-Ying Pan, Jih-Jin Tsai, Chun-Hong Chen

    Viruses   Vol. 12 ( 10 )   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/v12101105

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  26. C-Type Lectins Link Immunological and Reproductive Processes in Aedes aegypti Reviewed International coauthorship

    Hsing-Han Li, Yu Cai, Jian-Chiuan Li, Matthew P. Su, Wei-Liang Liu, Lie Cheng, Shu-Jen Chou, Guann-Yi Yu, Horng-Dar Wang, Chun-Hong Chen

    iScience   Vol. 23 ( 9 ) page: 101486   2020.9

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    DOI: 10.1016/j.isci.2020.101486

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  27. Buzzkill: targeting the mosquito auditory system Reviewed International coauthorship

    Marta Andrés, Matthew P Su, Joerg Albert, Lauren J Cator

    Current Opinion in Insect Science   Vol. 40   page: 11 - 17   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.cois.2020.04.003

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  28. Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster Reviewed International coauthorship

    Po-Lin Chen, Kai-Ting Huang, Chu-Ya Cheng, Jian-Chiuan Li, Hsiao-Yen Chan, Tzu-Yang Lin, Matthew P. Su, Wei-Yuan Yang, Henry C. Chang, Horng-Dar Wang, Chun-Hong Chen

    Nature Communications   Vol. 11 ( 1 ) page: 2592   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    DOI: 10.1038/s41467-020-16335-0

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  29. Epidemiological analysis of the Kaohsiung city strategy for dengue fever quarantine and epidemic prevention Reviewed International coauthorship

    Chao-Ying Pan, Wei-Liang Liu, Matthew-P. Su, Te-Pin Chang, Hui-Pin Ho, Pei-Yun Shu, Joh-Jong Huang, Li-Jen Lin, Chun-Hong Chen

    BMC Infectious Diseases   Vol. 20 ( 1 ) page: 347   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12879-020-4942-y

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  30. Local Delivery of Therapeutics to the Inner Ear: The State of the Science Reviewed

    Caroline R. Anderson, Carol Xie, Matthew P. Su, Maria Garcia, Helen Blackshaw, Anne G. M. Schilder

    Frontiers in Cellular Neuroscience   Vol. 13   page: 418   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fncel.2019.00418

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  31. Early phase trials of novel hearing therapeutics: Avenues and opportunities Reviewed International coauthorship

    Anne G.M. Schilder, Matthew P. Su, Rishi Mandavia, Caroline R. Anderson, Evie Landry, Tanjinah Ferdous, Helen Blackshaw

    Hearing Research   Vol. 380   page: 175 - 186   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.heares.2019.07.003

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  32. Hearing Protection, Restoration, and Regeneration Reviewed International coauthorship

    Anne G. M. Schilder, Matthew P. Su, Helen Blackshaw, Lawrence Lustig, Hinrich Staecker, Thomas Lenarz, Saaid Safieddine, Carina S. Gomes-Santos, Ralph Holme, Athanasia Warnecke

      Vol. 40 ( 5 ) page: 559 - 570   2019.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MAO.0000000000002194

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  33. Sex and species specific hearing mechanisms in mosquito flagellar ears Reviewed International coauthorship

    Matthew P. Su, Marta Andrés, Nicholas Boyd-Gibbins, Jason Somers, Joerg T. Albert

    Nature Communications   Vol. 9 ( 1 ) page: 3911   2018.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Nature  

    DOI: 10.1038/s41467-018-06388-7

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  34. Evolutionary changes in transcription factor coding sequence quantitatively alter sensory organ development and function Reviewed International coauthorship

    Simon Weinberger, Matthew P Topping, Jiekun Yan, Annelies Claeys, Natalie De Geest, Duru Ozbay, Talah Hassan, Xiaoli He, Joerg T Albert, Bassem A Hassan, Ariane Ramaekers

    eLife   Vol. 6   2017.4

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    DOI: 10.7554/eLife.26402

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    CiNii Research

  35. A Mechanosensory Pathway to the Drosophila Circadian Clock Reviewed

    A. Simoni, W. Wolfgang, M. P. Topping, R. G. Kavlie, R. Stanewsky, J. T. Albert

    Science   Vol. 343 ( 6170 ) page: 525 - 528   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Association for the Advancement of Science ({AAAS})  

    DOI: 10.1126/science.1245710

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MISC 1

  1. ショウジョウバエにおける聴覚ニューロン群の種特異的な応答特性

    大橋拓朗, 石川由希, 粟崎健, 蘇馬賦, 蘇馬賦, 上川内あづさ, 上川内あづさ

    日本神経化学会大会抄録集(Web)   Vol. 65th   2022

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Research Project for Joint Research, Competitive Funding, etc. 1

  1. Reducing global Aedes aegypti mosquito-borne disease transmission by developing control tools targeting the circadian clock

    2022.1 - 2026.4

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    Authorship:Principal investigator  Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. Investigating the influence of two major Ionotropic Receptors on Aedes aegypti mosquito acoustic behaviors

    2022.4 - 2025.3

    KAKENHI  Grant-in-Aid for Early-Career Scientists 

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    Authorship:Principal investigator  Grant type:Competitive