2022/03/18 更新

写真a

スズキ マサシ
鈴木 将史
SUZUKI Masashi
所属
医学部附属病院 検査部 助教
大学院担当
大学院医学系研究科
職名
助教

学位 1

  1. 博士(医学) ( 2017年3月   名古屋大学 ) 

現在の研究課題とSDGs 1

  1. 自律神経

経歴 1

  1. 名古屋大学   医学部附属病院 検査部   助教

    2021年5月 - 現在

 

論文 15

  1. Impaired pain processing and its association with attention disturbance in patients with amyotrophic lateral sclerosis 査読有り

    Harada Yumiko, Nakamura Tomohiko, Suzuki Masashi, Ueda Masamichi, Hirayama Masaaki, Katsuno Masahisa

    NEUROLOGICAL SCIENCES   42 巻 ( 8 ) 頁: 3327 - 3335   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Neurological Sciences  

    Background: Cognitive dysfunction characterized by executive dysfunction and persistent attention function has been reported in patients with amyotrophic lateral sclerosis (ALS); however, it is unclear if this contributes to the pain processing deficits associated with the disease. Objective: We clarified the relationship between pain processing and both cognitive function and sensory symptoms in patients with ALS. Methods: We enrolled 23 patients with ALS and 14 healthy control subjects. We examined pain-related somatosensory evoked potentials (SEPs) using an intra-epidermal needle electrode. We evaluated cognitive function and the clinical characteristics of sensation and analyzed their relationships with pain-related SEPs. Results: Pain-related SEP amplitudes were significantly lower, while the rate of amplitude attenuation due to habituation or change in attention was significantly greater in patients with ALS than in control subjects. There were no significant differences in pain-related SEP parameters between patients with or without sensory symptoms. Instead, pain-related SEP amplitude and its rate of attenuation were correlated with cognitive dysfunction, particularly with attention domains. Conclusions: Our results suggest that attention deficit, but not sensory nerve involvement, is a major cause of the alterations in pain-related SEP in patients with ALS.

    DOI: 10.1007/s10072-020-05028-7

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    その他リンク: http://link.springer.com/article/10.1007/s10072-020-05028-7/fulltext.html

  2. ANCA-associated neuropathy in systemic sclerosis: A case report and review of literature 査読有り

    Takenaka Kayo, Takeichi Takuya, Nishi Ryoji, Suzuki Masashi, Koike Haruki, Katsuno Masahisa, Ogawa-Momohara Mariko, Muro Yoshinao, Akiyama Masashi

    JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY   4 巻 ( 2 ) 頁: 34 - 36   2021年4月

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    記述言語:英語   出版者・発行元:Journal of Cutaneous Immunology and Allergy  

    Systemic sclerosis (SSc) is a multi-system autoimmune disease. Anti-neutrophil cytoplasmic antibodies (ANCA) are autoantibodies directed against enzymes found within primary granules of neutrophils and lysosomes in monocytes. Although up to 12% of SSc patients have ANCA, only a minority of these patients develop an overlap syndrome with ANCA-associated vasculitis. We summarize previous reports on SSc patients with ANCA-associated neuropathy. In all the reported cases, the SSc diagnosis preceded the ANCA-associated neuropathy diagnosis. Seven of the eight patients with limited cutaneous SSc had interstitial lung disease (ILD). Thus, patients with ANCA-associated neuropathy in lSSc may be prone to complication with ILD.

    DOI: 10.1002/cia2.12153

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  3. The wide-ranging clinical and genetic features in Japanese families with valosin-containing protein proteinopathy 査読有り

    Ando Takashi, Nakamura Ryoichi, Kuru Satoshi, Yokoi Daichi, Atsuta Naoki, Koike Haruki, Suzuki Masashi, Hara Kazuhiro, Iguchi Yohei, Harada Yumiko, Yoshida Yusuke, Hattori Makoto, Murakami Ayuka, Noda Seiya, Kimura Seigo, Sone Jun, Nakamura Tomohiko, Goto Yoji, Mano Kazuo, Okada Hisashi, Okuda Satoshi, Nishino Ichizo, Ogi Tomoo, Sobue Gen, Katsuno Masahisa

    NEUROBIOLOGY OF AGING   100 巻   頁: 120.e1 - 120.e6   2021年4月

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    記述言語:英語   出版者・発行元:Neurobiology of Aging  

    Mutations in the valosin-containing protein (VCP) gene are known to cause various neurodegenerative disorders. Here, we report 8 Japanese patients [6 men, 2 women; median age at onset: 49.5 (range, 35–58) years] from 5 unrelated families with VCP missense mutations. Although 7 of 8 patients were diagnosed with either inclusion body myopathy or amyotrophic lateral sclerosis, 1 patient showed demyelinating polyneuropathy, which was confirmed by longitudinal nerve conduction studies. Sural nerve biopsy of the patient revealed intranuclear ubiquitin staining in Schwann cells. Three known pathogenic VCP mutations (p.Arg191Gln, p.Arg155Cys, and p.Ile126Phe) were detected. A novel mutation, c.293 A>T (p.Asp98Val), was also identified in a patient with amyotrophic lateral sclerosis and frontotemporal dementia. This mutation was predicted to be “deleterious” or “disease causing” using in silico mutation analyses. In conclusion, demyelinating polyneuropathy may be a novel phenotype caused by VCP mutations. The p.Asp98Val mutation was found to be a novel pathogenic mutation of VCP proteinopathy. We believe our cases represent a wide clinical spectrum of VCP mutations.

    DOI: 10.1016/j.neurobiolaging.2020.10.028

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  4. Difference in cardiovascular response during orthostatic stress in Parkinson's disease and multiple system atrophy 査読有り

    Nakamura Tomohiko, Suzuki Masashi, Ueda Masamichi, Harada Yumiko, Hirayama Masaaki, Katsuno Masahisa

    JOURNAL OF NEURAL TRANSMISSION   127 巻 ( 10 ) 頁: 1377 - 1386   2020年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Neural Transmission  

    Although orthostatic hypotension is more prominent in multiple system atrophy (MSA) than in Parkinson’s disease (PD), there is no study comparing the degree of decrease in total peripheral resistance and cardiac response during orthostatic stress between both diseases. In this study, we examined whether there is a difference in cardiovascular response between MSA and PD. We examined the results of the head-up tilt test in 68 patients with MSA, 28 patients with cardiac non-denervated PD, and 70 patients with cardiac denervated PD whose total peripheral resistance after 60° tilting was lower than the value at 0°. Differences in cardiac output and blood pressure changes were compared against the decrease in total peripheral resistance. There was no difference in the degree of decrease in total peripheral resistance among the three groups. However, the slope of the regression line revealed that the increase in cardiac output against the change in total peripheral resistance was significantly lower in the MSA group than in the cardiac non-denervated and denervated PD groups, and that the decrease in systolic blood pressure against the change in total peripheral resistance was significantly greater in the MSA group than in the cardiac non-denervated and denervated PD groups. In MSA, the cardiac response during orthostatic stress is lower than that in PD, possibly underlying the fact that orthostatic hypotension is more prominent in MSA than in PD.

    DOI: 10.1007/s00702-020-02241-8

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  5. A nerve conduction study predicts the prognosis of sporadic amyotrophic lateral sclerosis 査読有り 国際誌

    Imai Eriko, Nakamura Tomohiko, Atsuta Naoki, Nakatochi Masahiro, Suzuki Masashi, Harada Yumiko, Nakamura Ryoichi, Hayashi Naoki, Sobue Gen, Katsuno Masahisa

    JOURNAL OF NEUROLOGY   267 巻 ( 9 ) 頁: 2524 - 2532   2020年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Neurology  

    Objective: To clarify the relationship between nerve conduction study (NCS) and prognosis in patients with amyotrophic lateral sclerosis (ALS). Methods: We included 190 patients with sporadic ALS. We used onset age, sex, onset site (bulbar vs. spinal), revised El Escorial criteria category (definite vs. others), and the King’s clinical systems, and the Milano–Torino (MiToS) functional staging systems, and decline rates of revised ALS functional rating scale (ALSFRS-R) as known prognostic factors. An NCS was performed on the median, ulnar, tibial, and sural nerves. The endpoint was death or the introduction of tracheostomy positive-pressure ventilation. Multivariate analysis for each NCS variable, known prognostic factors was performed using Cox stepwise proportional hazards analysis. Univariate analysis was performed for NCS variables that showed a significant association with prognosis in multivariate analysis. Survival was analyzed with a Kaplan–Meier curve and log-rank test. Results: The Cox model identified the compound muscle action potential (CMAP) and sensory nerve action potential (SNAP) amplitudes of the median nerve as prognostic factors. In the log-rank test, patients with higher median nerve CMAP amplitude had a significantly better prognosis than those with lower amplitude, regardless of age. And prognosis was better in the group with lower median nerve SNAP amplitude only in patients younger than the 25th percentile (~ 57 years). Conclusions: CMAP and SNAP amplitudes of the median nerve are considered to be independent prognostic factors of sporadic ALS.

    DOI: 10.1007/s00415-020-09858-5

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  6. Relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the medulla oblongata in multiple system atrophy 査読有り 国際誌

    Suzuki Masashi, Nakamura Tomohiko, Hirayama Masaaki, Ueda Miki, Imai Eriko, Harada Yumiko, Katsuno Masahisa

    CLINICAL AUTONOMIC RESEARCH   30 巻 ( 3 ) 頁: 231 - 238   2020年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical Autonomic Research  

    Purpose: Neurodegeneration of the nucleus ambiguus and the dorsal vagal motor nucleus has been implicated in cardiac parasympathetic dysfunction in multiple system atrophy (MSA). The nucleus ambiguus and the dorsal vagal motor nucleus, which are located in the medulla oblongata (MO), control the autonomic—specifically, the parasympathetic—functions of the body. The aim of our study was to investigate the relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the MO in MSA by quantitatively analyzing magnetic resonance imaging (MRI) outcome measures. Methods: We retrospectively assessed 40 consecutive patients with probable MSA and 25 age- and sex-matched controls. The anteroposterior diameter of the MO at two locations (MO diameter-A and -B) and the diameters of the midbrain and pons were measured by conventional MRI. A cardiac parasympathetic function score (CP-score) and cardiac sympathetic function score (CS-score) were generated by calculating the z-scores of multiple autonomic function tests. The relationship between the scores and the measured diameters of the brainstem was also investigated. Results: The CP-score and CS-score were significantly lower in the patients with MSA than in the controls (CP-score: 0.61 ± 0.75 vs. − 0.38 ± 0.52, p < 0.001; CS-score: 0.91 ± 1.06 vs. − 0.57 ± 1.07, p < 0.001). Also, in the patients with MSA, the CP-score was significantly correlated with MO diameter-A (r = 0.40, p = 0.010), and the CS-score was significantly correlated with the diameter of the midbrain (r = 0.33, p = 0.038). Conclusion: The anteroposterior diameter of the MO is a potential imaging marker of parasympathetic dysfunction in MSA.

    DOI: 10.1007/s10286-020-00675-4

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  7. Steroid-responsive recurrent tumefactive demyelination with multiple petechial hemorrhages along non-displaced medullary veins 査読有り

    Tsuboi Takashi, Harada Yumiko, Suzuki Masashi, Ando Takashi, Atsuta Naoki, Ohka Fumiharu, Takeuchi Kazuhito, Taoka Toshiaki, Ohba Shigeo, Nakaguro Masato, Abe Masato, Nakashima Ichiro, Yoshida Mari, Katsuno Masahisa

    CLINICAL NEUROLOGY AND NEUROSURGERY   193 巻   頁: 105764   2020年6月

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    記述言語:日本語   出版者・発行元:Clinical Neurology and Neurosurgery  

    DOI: 10.1016/j.clineuro.2020.105764

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  8. Association of orthostatic blood pressure with the symptoms of orthostatic hypotension and cognitive impairment in patients with multiple system atrophy 査読有り 国際誌

    Ueda Miki, Nakamura Tomohiko, Suzuki Masashi, Imai Eriko, Harada Yumiko, Hara Kazuhiro, Hirayama Masaaki, Katsuno Masahisa

    JOURNAL OF CLINICAL NEUROSCIENCE   75 巻   頁: 40 - 44   2020年5月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Clinical Neuroscience  

    The degree and frequency of orthostatic hypotension (OH) are high in patients with multiple system atrophy (MSA); however, the association of orthostatic blood pressure (BP) with the symptoms of OH and cognitive impairment in these patients remains unclear. The aim of this study was to clarify whether absolute BP and/or changes in BP during standing are related to OH symptoms and cognitive impairment in patients with MSA. Thirty-two patients with MSA were examined using the head-up tilt and cognitive function tests. OH symptoms were evaluated using a patient-reported scale. The results were compared with those for 15 age- and sex-matched healthy controls. Seventeen of the 32 (53.1%) patients had OH, with eight of them exhibiting OH symptoms, which were related to the absolute BP value at 60° tilt. However, OH symptoms were not related to the degree of decrease in BP during the tilt test, and they were frequently observed in patients with a mean BP of <80 mmHg at 60° tilt (sensitivity, 67%; specificity, 91%). Cognitive dysfunction assessed by the Mini-Mental State Examination (MMSE; ≤ 26) was also associated with a low mean BP at 60° tilt (odds ratio, 1.32; 95% confidence interval, 1.04–1.67; p = 0.02). The upright BP value is associated with OH symptoms and the MMSE score in patients with MSA. Thus, careful observation of OH symptoms can enable early management of BP and the detection of cognitive impairment in these patients.

    DOI: 10.1016/j.jocn.2020.03.040

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  9. Impact of orthostatic hypotension on wheelchair use in patients with Parkinson's disease 査読有り

    Nakamura Tomohiko, Suzuki Masashi, Ueda Masamichi, Harada Yumiko, Hirayama Masaaki, Katsuno Masahisa

    JOURNAL OF NEURAL TRANSMISSION   127 巻 ( 3 ) 頁: 379 - 383   2020年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Neural Transmission  

    Wheelchair use is an important indicator of disease progression in Parkinson’s disease (PD). Here, we investigated whether orthostatic hypotension (OH) affects the time to wheelchair use. We examined 33 PD patients with OH and 95 without OH. Median time to start using a wheelchair calculated from the time of disease onset was significantly shorter in patients with OH than in those without OH (12.0 vs 19.0 years; p < 0.001). Thus, appropriate management of OH and motor function is necessary.

    DOI: 10.1007/s00702-019-02127-4

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  10. Aceruloplasminemia with Abnormal Compound Heterozygous Mutations Developed Neurological Dysfunction during Phlebotomy Therapy 査読有り

    Watanabe Maki, Ohyama Ken, Suzuki Masashi, Nosaki Yasunobu, Hara Takashi, Iwai Katsushige, Kono Satoshi, Miyajima Hiroaki, Mokuno Kenji

    Internal Medicine   57 巻 ( 18 ) 頁: 2713 - 2718   2018年

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    記述言語:英語   出版者・発行元:一般社団法人 日本内科学会  

    <p>Aceruloplasminemia is an autosomal recessive inherited disorder caused by ceruloplasmin gene mutations. The loss of ferroxidase activity of ceruloplasmin due to gene mutations causes a disturbance in cellular iron transport. We herein describe a patient with aceruloplasminemia, who presented with diabetes mellitus that was treated by insulin injections, liver hemosiderosis treated by phlebotomy therapy, and neurological impairment. A genetic analysis of the ceruloplasmin gene revealed novel compound heterozygous mutations of c.1286_1290insTATAC in exon 7 and c.2185delC in exon 12. This abnormal compound heterozygote had typical clinical features similar to those observed in aceruloplasminemia patients with other gene mutations. </p>

    DOI: 10.2169/internalmedicine.9855-17

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  11. Relationship between cardiac parasympathetic dysfunction and atrophy of the medulla oblongata in multiple system atrophy

    Suzuki M., Nakamura T., Hirayama M., Ueda M., Imai E., Katsuno M.

    JOURNAL OF THE NEUROLOGICAL SCIENCES   381 巻   頁: 921 - 921   2017年10月

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    記述言語:日本語  

    DOI: 10.1016/j.jns.2017.08.2590

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  12. Cardiac parasympathetic dysfunction in the early phase of Parkinson's disease 査読有り

    Suzuki Masashi, Nakamura Tomohiko, Hirayama Masaaki, Ueda Miki, Katsuno Masahisa, Sobue Gen

    JOURNAL OF NEUROLOGY   264 巻 ( 2 ) 頁: 333 - 340   2017年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00415-016-8348-0

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  13. Lower body mass index is associated with orthostatic hypotension in Parkinson's disease 査読有り

    Nakamura Tomohiko, Suzuki Masashi, Ueda Miki, Hirayama Masaaki, Katsuno Masahisa

    JOURNAL OF THE NEUROLOGICAL SCIENCES   372 巻   頁: 14 - 18   2017年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jns.2016.11.027

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  14. Association of leptin with orthostatic blood pressure changes in Parkinson's disease 招待有り 査読有り

    Nakamura Tomohiko, Suzuki Masashi, Okada Akinori, Suzuki Junichiro, Hasegawa Satoru, Koike Haruki, Hirayama Masaaki, Katsuno Masahisa, Sobue Gen

    MOVEMENT DISORDERS   31 巻 ( 9 ) 頁: 1417 - 1421   2016年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/mds.26678

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  15. Impaired Pain Processing Correlates with Cognitive Impairment in Parkinson's Disease

    Okada Akinori, Nakamura Tomohiko, Suzuki Junichiro, Suzuki Masashi, Hirayama Masaaki, Katsuno Masahisa, Sobue Gen

    Japanese Journal of Medicine   55 巻 ( 21 ) 頁: 3113 - 3118   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:一般社団法人 日本内科学会  

    <p><b>Objective </b>Pain and cognitive impairment are important clinical features in patients with Parkinson's disease (PD). Although pain processing is associated with the limbic system, which is also closely linked to the cognitive function, the association between pain and cognitive impairment in PD is still not well understood. The aim of the study was to investigate the association between pain processing and cognitive impairment in patients with PD. </p><p><b>Methods </b>Forty-three patients with PD and 22 healthy subjects were studied. Pain-related somatosensory evoked potentials (SEPs) were generated using a thin needle electrode to stimulate epidermal Aδ fibers. Cognitive impairment was evaluated using the Mini-Mental State Examination (MMSE), the Frontal Assessment Battery, and Japanese version of the Montreal Cognitive Assessment (MoCA-J), and their correlation with pain-related SEPs was investigated. </p><p><b>Results </b>The N1/P1 amplitude was significantly lower in PD patients than the controls. N1/P1 peak-to-peak amplitudes correlated with the MMSE (r=0.66, p<0.001) and MoCA-J scores (r=0.38, p<0.01) in patients with PD. These amplitudes also strongly correlated with the domains of attention and memory in the MMSE (attention, r=0.52, p<0.001; memory, r=0.40, p<0.01) and MoCA-J (attention, r=0.45, p<0.005; memory, r=0.48, p<0.001), but not in control subjects. </p><p><b>Conclusion </b>A good correlation was observed between the decreased amplitudes of pain-related SEPs and an impairment of attention and memory in patients with PD. Our results suggest that pathological abnormalities of the pain pathway are significantly linked to cognitive impairment in PD. </p>

    DOI: 10.2169/internalmedicine.55.7067

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    CiNii Research

▼全件表示

書籍等出版物 1

  1. 脳神経内科

    鈴木将史、中村友彦、勝野雅央( 担当: 分担執筆 ,  範囲: パーキンソン病病の自律神経障害と画像 (特集 Parkinson病の自律神経障害))

    科学評論社  2020年2月 

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    担当ページ:226-232   記述言語:日本語

講演・口頭発表等 3

  1. ウェアラブルデバイスを用いたパーキンソン病の心拍変動低下の検出

    鈴木将史

    第15回パーキンソン病・運動障害疾患コングレス  2021年7月 

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    開催年月日: 2021年7月

    記述言語:日本語   会議種別:口頭発表(一般)  

  2. ウェアラブルデバイスを用いたパーキンソン病の長時間心拍変動の解析

    鈴木将史

    第62回日本神経学会学術大会  2021年5月 

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    開催年月日: 2021年5月

    記述言語:日本語   会議種別:口頭発表(一般)  

  3. ウェアラブルデバイスを用いたパーキンソン病における睡眠障害の評価

    鈴木将史

    第61回日本神経学会学術大会  2020年9月 

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    開催年月日: 2020年8月 - 2020年9月

    記述言語:日本語   会議種別:口頭発表(一般)  

科研費 2

  1. 副交感神経障害の検出によるパーキンソン病診断マーカーの確立

    研究課題/研究課題番号:20K16597  2020年4月 - 2022年3月

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    鈴木 将史

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    担当区分:研究代表者 

    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    パーキンソン病では、便秘などの自律神経障害が運動症状の出現より早期に出現することが知られている。自律神経障害の検出はパーキンソン病の早期診断方法のひとつとして期待されるが、確立された方法はない。本研究では日常診療で行われている自律神経機能検査(心筋MIBGシンチグラフィー、ヘッドアップチルト試験など)に加え、ウェアラブルデバイスを用いた長時間の心拍変動の解析、頸部超音波を用いた迷走神経断面積の測定を行う。複数の自律神経障害の検出方法を併せて解析することにより、パーキンソン病の早期診断や鑑別に有用な自律神経障害の指標の同定を行っていく。
    パーキンソン病(PD)37例、パーキンソン症候群27例、コントロール16例において頸動脈エコーを用いて迷走神経断面積測定を行った。迷走神経断面積はPDやパーキンソン症候群において低い傾向であったが、現時点では有意差は認めなかった。迷走神経断面積と心拍変動における副交感神経パラメーターとの相関について検討したところ、PDではCVR-Rなどの一部のパラメーターに有意な相関を認め(左右面積計とCVR-R ; r = 0.46, p = 0.009など)、迷走神経断面積は副交感神経機能を反映している可能性が示唆された。またPD27例、コントロール23例においてウェアラブルデバイスを用いて取得した長時間心拍変動から副交感神経パラメーターを解析し、検討を行った。PDにおいて、CVR-R等の複数の副交感神経パラメーターが有意に低下していた(CVR-R ; 1.15 ± 0.33 vs 0.65 ± 0.24など)。さらにこれらのパラメータを用いてROC解析を行ったところ、ウェアラブルデバイスから取得した副交感神経パラメーターはPDの鑑別に有用である可能性が示された(CVR-R ; AUC = 0.90,感度 = 0.81, 特異度 = 0.91など)。PDを含む神経変性疾患では臨床症状の出現より以前に、神経の変性が始まっていると考えられている。早い段階より治療介入を行うために、非侵襲的な早期の診断マーカーの確立が必要とされている。PDにおいて副交感神経障害は、運動症状の出現に先行する可能性がある病態のひとつである。迷走神経断面積はPDの副交感神経機能を反映している可能性があり、ウェアラブルデバイスを用いた副交感神経機能の評価と組み合わせることにより、PDの副交感神経障害を検出し、非侵襲的にPDの早期診断や鑑別が行える可能性がある。
    2021年3月の時点で、頸動脈エコーを用いた迷走神経断面積測定は、パーキンソン病37例、パーキンソン症候群27例、コントロール16例に行っている。ウェアラブルデバイスを用いた副交感神経機能の評価はパーキンソン病27例、コントロール23例に行っている。概ね予定通りに進行しており、次年度も症例を蓄積していく予定である。
    症例数については、次年度も本年度と同様に蓄積していく予定である。頸動脈エコーを用いた迷走神経断面積測定については、パーキンソン病とコントロールにおいて現時点で有意差を認めておらず、解析方法については再検討が必要である可能性がある。具体的には年齢や性別、副交感神経パラメーター等を考慮したうえでの解析方法を検討していく。迷走神経断面積とウェアラブルデバイスを用いた副交感神経機能の評価を組み合わせた解析方法についても、検討を進めていく予定である。

  2. ウェアラブルデバイスを用いたパーキンソン病早期診断マーカーの検討

    研究課題/研究課題番号:18K15415  2018年4月 - 2020年3月

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    鈴木 将史

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    担当区分:研究代表者 

    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    パーキンソン病では早期より自律神経障害が起こり、心拍変動(脈拍の変化)が低下する可能性が示されている。本研究ではウェアラブルデバイスを用いてパーキンソン病患者の心拍変動を長時間に渡り記録し、活動状態と合わせて解析を行った。パーキンソン病患者では健常人と比較し心拍変動のパラメーターが有意に低下することが示され、ウェアラブルデバイスを用いて自律神経障害を検出できる可能性が示された。また長時間記録と活動状態の解析により、自律神経障害を検出に適した心拍変動パラメーターやタイミングの同定をすることができた。