2022/05/12 更新

写真a

オカモト マサムネ
岡本 眞宗
OKAMOTO Masamune
所属
医学部附属病院 小児がん治療センター 病院助教
職名
病院助教

学位 1

  1. 学士(医学) ( 2013年4月   名古屋大学 ) 

 

論文 13

  1. Patients with gastric volvulus recurrence have high incidence of wandering spleen requiring laparoscopic gastropexy and splenopexy 査読有り

    Nakagawa Yoichi, Uchida Hiroo, Amano Hizuru, Hinoki Akinari, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Takada Shunya, Kato Daiki

    PEDIATRIC SURGERY INTERNATIONAL   38 巻 ( 6 ) 頁: 875 - 881   2022年6月

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  2. Evaluation of minimally invasive surgical skills training: comparing a neonatal esophageal atresia/tracheoesophageal fistula model with a dry box 査読有り

    Deie Kyoichi, Nakagawa Yoichi, Uchida Hiroo, Hinoki Akinari, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Fujiogi Michimasa, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Takada Shunya, Maeda Takuya

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES     2022年3月

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  3. Utility of endoscopic retrograde cholangiopancreatography in management of pediatric pancreaticobiliary disease 査読有り

    Makita Satoshi, Amano Hizuru, Kawashima Hiroki, Hinoki Akinari, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi, Uchida Hiroo

    BMC PEDIATRICS   22 巻 ( 1 ) 頁: 134   2022年3月

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  4. Safety and feasibility of primary radical surgery for meconium peritonitis considering patients' general condition and perioperative findings 査読有り

    Nakagawa Yoichi, Uchida Hiroo, Amano Hizuru, Hinoki Akinari, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Takada Shunya, Maeda Takuya

    NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 1 ) 頁: 148 - 154   2022年2月

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  5. Urinary N-1,N-12-diacetylspermine as a biomarker for pediatric cancer: a case-control study 査読有り

    Yokota Kazuki, Hinoki Akinari, Hiramatsu Kyoko, Amano Hizuru, Kawamura Machiko, Kuwatsuka Yachiyo, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi, Uchida Hiroo, Kawakita Masao

    PEDIATRIC SURGERY INTERNATIONAL   37 巻 ( 12 ) 頁: 1659 - 1665   2021年12月

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    記述言語:日本語   出版者・発行元:Pediatric Surgery International  

    Purpose: Minimally invasive examinations are particularly important in pediatric patients. Although the significance of urinary N1,N12-diacetylspermine (DiAcSpm) as a tumor marker (TM) has been reported in many types of adult cancers, its usefulness in pediatric cancers has not been reported. This may be due to urinary DiAcSpm level variations with age. This study aims to measure the normal levels of urinary DiAcSpm in healthy individuals and investigate its usefulness as a TM in childhood cancer. Methods: Urinary samples were collected from pediatric patients with and without cancer. The urinary DiAcSpm levels were measured, and the values were compared. Results: A total of 32 patients with cancer and 405 controls were enrolled in the study. Of the 32 patients, 13 had neuroblastoma, 9 had malignant lymphoma (ML), and 10 had leukemia. In the control group, the urinary DiAcSpm values markedly fluctuated among those with young age, especially infants; meanwhile, the values converged among those aged roughly 10 years and above. The sensitivity of DiAcSpm was significantly different among the three types of cancers: neuroblastoma (30.8%), ML (77.8%), and leukemia (40%). Conclusion: The urinary DiAcSpm value is a useful TM for both screening and follow-up of ML.

    DOI: 10.1007/s00383-021-04987-y

    Web of Science

    Scopus

    PubMed

  6. Clinical characteristics and outcomes of the right congenital diaphragmatic hernia compared to the left: a 10-year single-center experience 査読有り

    Okamoto Masamune, Amano Hizuru, Uchida Hiroo, Hinoki Akinari, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi

    PEDIATRIC SURGERY INTERNATIONAL   37 巻 ( 12 ) 頁: 1675 - 1681   2021年12月

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    記述言語:日本語   出版者・発行元:Pediatric Surgery International  

    Purpose: The features of right-sided congenital diaphragmatic hernias (RCDHs) are quite different from those of left-sided CDHs (LCDHs). We have summarized the features of RCDHs experienced in our institution. Methods: This retrospective study analyzed the cases of patients with CDH registered at our institution between 2011 and 2020. Defects on each side were compared based on prenatal diagnosis, medical treatment, type of surgery, and outcomes. Results: A total of 101 patients underwent surgery at our institution during the neonatal period, and 11 had RCDHs. RCDHs and LCDHs were significantly different in terms of extracorporeal membrane oxygenation (36% vs. 6%, p = 0.002), patch repair (81% vs. 28%, p < 0.001), recurrence rate (36% vs. 11%, p = 0.022), and length of hospital stay (117 days vs. 51 days, p = 0.012). The severity of the fetal diagnosis did not reflect postnatal severity. All patients with RCDH survived to discharge, and there was no significant difference in survival rate between the right and left sides. Conclusion: Neonates with RCDH required more intensive treatments; however, the survival rate was comparable between RCDH and LCDH. RCDH was significantly different from LCDH and an optimal treatment strategy for RCDHs should be established.

    DOI: 10.1007/s00383-021-04999-8

    Web of Science

    Scopus

    PubMed

  7. An imaging study on tracheomalacia in infants with esophageal atresia: the degree of tracheal compression by the brachiocephalic artery is a good indicator for therapeutic intervention 査読有り

    Sumida Wataru, Tainaka Takahisa, Shirota Chiyoe, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Yasui Akihiro, Okamoto Masamune, Nakagawa Yoichi, Hinoki Akinari, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   37 巻 ( 12 ) 頁: 1719 - 1724   2021年12月

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    記述言語:日本語   出版者・発行元:Pediatric Surgery International  

    Purpose: Tracheomalacia (TM) is a frequent complication after esophageal atresia (EA) repair. This study aimed to review patients who underwent aortopexy for TM after EA repair and to compare their imaging features. Methods: The patients who underwent thoracoscopic EA repair and contrast-enhanced computed tomography (CECT) at our hospital between 2013 and 2020 were retrospectively reviewed. The ratio of the lateral and anterior–posterior diameter of the trachea (LAR) where the brachiocephalic artery (BCA) crosses the trachea was defined. The LAR of the patients who underwent CECT for asymptomatic pulmonary disease was set as a normal reference. The Z-score of each LAR was calculated and compared between the patients that did or did not undergo aortopexy. Results: A total of 51 patients represented the controls, 5 patients underwent aortopexy, and 12 patients were discharged without surgery. The mean LARs in the patients who underwent aortopexy, did not undergo aortopexy, and controls were 3.54, 1.54, and 1.15, respectively. The mean Z-score of the aortopexy group was 21.2. After successful aortopexy, each patient’s LAR decreased to < 1.5. Conclusion: Aortopexy was preferred if the trachea was compressed by the BCA. The LAR is a useful indicator for predicting the therapeutic effect of aortopexy.

    DOI: 10.1007/s00383-021-04985-0

    Web of Science

    Scopus

    PubMed

  8. Single-incision laparoscopic percutaneous extraperitoneal closure (SILPEC) for inguinal hernia with prolapsed ovary 査読有り

    Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi, Hinoki Akinari, Uchida Hiroo

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES     2021年10月

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    記述言語:日本語   出版者・発行元:Surgical Endoscopy  

    Background: Most studies reporting the outcomes of laparoscopic ovarian prolapsed hernia operations with large sample sizes are based on intracorporeal closure, while studies on extraperitoneal closure have limited sample sizes. We proactively used the single-incision laparoscopic percutaneous extraperitoneal closure (SILPEC) technique and obtained favorable outcomes, which we report in this paper. Methods: We retrospectively reviewed patients who had undergone laparoscopic surgery for inguinal hernia at our institution. They were retrospectively classified into two groups based on the pre- or intraoperative diagnosis of hernia with a prolapsed ovary, namely the prolapse group and the non-prolapse group, respectively. The data were statistically analyzed and p < 0.05 was considered statistically significant. Results: A total of 771 subjects underwent SILPEC during the study period, including 400 girls. Among them, 63 girls were diagnosed with an ovarian prolapsed hernia. SILPEC was successfully performed through a single port in all cases, with a single exception, in whom the forceps was inserted directly through the right lower quadrant to pull up the ovary. The duration of surgery in the prolapse group was not higher than that in the non-prolapse group. During the SILPEC surgery, the ovaries were successfully reverted into the abdominal cavity by external compression of the inguinal area alone in 38 of the 63 patients. In the remaining 25 cases, the ovaries were reverted into the abdominal cavity by external compression of the inguinal area and traction of the round ligament with forceps. None of these cases failed to return to the ovaries. Conclusion: Our study results indicate that SILPEC may be performed safely for the treatment of ovarian prolapsed inguinal hernia. Since the ovary and fallopian tube are close to the internal inguinal ring due to the short round ligament, the procedure requires careful suturing with traction of the round ligament.

    DOI: 10.1007/s00464-021-08777-4

    Web of Science

    Scopus

    PubMed

  9. Development of a novel diagnostic system for bile duct cancer using urinary metabolites. 査読有り

    Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Terui Yasushi, Oda Hirohisa, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Okamoto Masamune, Yasui Akihiro, Nakagawa Yoichi

    CANCER RESEARCH   81 巻 ( 13 )   2021年7月

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    記述言語:日本語  

    Web of Science

  10. NOVEL BIOMARKER DISCOVERY FOR CHILDHOOD RHABDOMYOSARCOMA USING URINARY METABOLITES 査読有り

    Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Terui Yasushi, Oda Hirohisa, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Okamoto Masamune, Yasui Akihiro, Nakagawa Yoichi

    PEDIATRIC BLOOD & CANCER   68 巻   頁: S46 - S46   2021年6月

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    記述言語:日本語  

    Web of Science

  11. Urinary biomarkers for monitoring treatment response in neuroblastoma patients. 査読有り

    Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Takahashi Yoshiyuki, Narita Atsushi, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Yasui Akihiro, Okamoto Masamune, Nakagawa Yoichi

    JOURNAL OF CLINICAL ONCOLOGY   39 巻 ( 15 )   2021年5月

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  12. 先天性胆道拡張症において術前MRI 画像による胆管狭窄部位の予測と術中胆管形成の検討 査読有り

    中川 洋一, 内田 広夫, 檜 顕成, 城田 千代栄, 住田 亙, 横田 一樹, 牧田 智, 岡本 眞宗, 滝本 愛太朗, 安井 昭洋, 高田 舜也, 前田 拓也

    日本膵・胆管合流異常研究会プロシーディングス   44 巻 ( 0 ) 頁: 72 - 73   2021年

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    記述言語:日本語   出版者・発行元:日本膵・胆管合流異常研究会  

    DOI: 10.34410/jspbm.44.0_72

    CiNii Research

  13. 先天性胆道拡張症の晩期合併症についての検討 査読有り

    城田 千代栄, 天野 日出, 檜 顕成, 住田 亙, 横田 一樹, 牧田 智, 岡本 眞宗, 滝本 愛太朗, 安井 昭洋, 高田 瞬也, 中川 洋一, 前田 拓也, 内田 広夫

    日本膵・胆管合流異常研究会プロシーディングス   44 巻 ( 0 ) 頁: 50 - 51   2021年

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    記述言語:日本語   出版者・発行元:日本膵・胆管合流異常研究会  

    DOI: 10.34410/jspbm.44.0_50

    CiNii Research

▼全件表示

科研費 2

  1. 腎芽腫メタボローム解析(尿/組織)による診断マーカーとオンコメタボライト探索

    研究課題/研究課題番号:22K07276  2022年4月 - 2025年3月

    科学研究費助成事業  基盤研究(C)

    岡本 眞宗

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    担当区分:研究代表者 

    配分額:4030000円 ( 直接経費:3100000円 、 間接経費:930000円 )

  2. 小児がんの診断治療に資する新規蛍光プローブの開発研究

    研究課題/研究課題番号:21K08640  2021年4月 - 2024年3月

    科学研究費助成事業  基盤研究(C)

    城田 千代栄, 浦野 泰照, 神谷 真子, 内田 広夫, 檜 顕成, 田井中 貴久, 住田 亙, 牧田 智, 横田 一樹, 滝本 愛太朗, 安井 昭洋, 岡本 眞宗

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    担当区分:研究分担者 

    小児がんは発見時にすでに進行していることが多く、遠隔転移症例の治療法の確立は喫緊の課題である。遠隔転移巣を確実に手術で摘出できれば患児の予後は劇的に改善するが、現時点では術中に微小転移巣を同定する方法がなく完全切除が難しいため、繰り返し手術が必要となることもある。そこで、特定の分子と反応すると分子構造が変化して強い蛍光を発したり、蛍光の色調が変化したりする機能性分子であり、生理活性物質の動態をリアルタイムに観測する研究ツールである蛍光プローブに着目した。本研究では、術中に迅速に簡便に小児がんの検出が可能な蛍光プローブの開発を行う。