Updated on 2022/05/23


YOKOI Sayaka
Nagoya University Hospital Otorhinolaryngology Assistant Professor
Graduate School
Graduate School of Medicine
Assistant Professor

Degree 1

  1. 博士(医学) ( 2021.3   名古屋大学 ) 


Papers 6

  1. Safety and Clinical Benefits of Laryngeal Closure in Patients with Amyotrophic Lateral Sclerosis

    Yokoi Sayaka, Nishio Naoki, Maruo Takashi, Hiramatsu Mariko, Mukoyama Nobuaki, Tsuzuki Hidenori, Wada Akihisa, Atsuta Naoki, Ito Daisuke, Tsuboi Takashi, Sobue Gen, Katsuno Masahisa, Fujimoto Yasushi, Sone Michihiko

    DYSPHAGIA     2022.5

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    Language:Japanese   Publisher:Dysphagia  

    This study evaluated the safety of laryngeal closure and post-surgical changes in swallowing function of patients with amyotrophic lateral sclerosis (ALS) and proposed an appropriate surgical strategy for patients with ALS. Clinical and surgical data of 26 consecutive patients with ALS who underwent laryngeal closure at Nagoya University Hospital in Japan between 2003 and 2020 were retrospectively analyzed. Changes in swallowing functions were evaluated before and approximately 1 month post-surgery using Neuromuscular Disease Swallowing Status Scale (NdSSS), and Functional Oral Intake Scale (FOIS). The median operation time was 126 min (range, 51–163 min), and the median intraoperative blood loss was 20 mL (range, 0–88 mL). Among the 26 ALS patients who underwent laryngeal closure, grade 1 (mild) complications occurred in three patients (12%); however, no severe complications were observed. After surgery, 25 patients (96%) maintained the swallowing function and only one patient (4%) had deteriorating NdSSS and FOIS scores. No patients were referred to our hospital due to severe aspiration pneumonia after the surgery. Two patients did not require a feeding tube after the surgery and returned to oral intake. Laryngeal closure may be a safe surgical procedure for preventing chronic aspiration and may also maintain swallowing function of patients with ALS. Further multicenter prospective studies using the gold standard videofluoroscopic swallowing examination are required to support our findings.

    DOI: 10.1007/s00455-022-10454-0

    Web of Science



  2. Surgical Strategy for Squamous Cell Carcinoma of the External Auditory Canal: Management of Locally Advanced Cases with Skull Base Involvement

    Goto S., Nishio N., Iwami K., Yoshida T., Maruo T., Mukoyama N., Tsuzuki H., Yokoi S., Wada A., Hiramatsu M., Hayashi Y., Kamei Y., Fujii M., Sone M., Fujimoto Y.

    Journal of Neurological Surgery, Part B: Skull Base     2022

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    Language:Japanese   Publisher:Journal of Neurological Surgery, Part B: Skull Base  

    ObjectiveSurgical indications for advanced-stage squamous cell carcinoma (SCC) of the external auditory canal (EAC) are highly dependent on the skull base surgery team. The aim of this study was to evaluate the surgical outcomes in patients with SCC of the EAC and to clarify the surgical indication of far advanced cases using the T4 subclassification. MethodsPatients with SCC of the EAC who underwent curative treatment from 2002 to 2021 at our hospital were retrospectively reviewed. Clinical and surgical results, including operative data, overall survival (OS), and disease-specific survival (DSS), were analyzed. To clarify the surgical indication for advanced-stage tumors, we proposed the T4 subclassification. ResultsIn the 46 patients included in the study, 8 patients had T1 tumors, 10 had T2 tumor, 5 had T3 tumors, and 23 had T4 tumors. The 5-year DSS with T1, T2, T3, and T4 tumors were 100, 85.7, 100, and 61.7%, respectively. No prognostic impacts for margin status were found between the 5-year OS and DSS (p = 0.23 and 0.13, respectively). Patients with far-advanced-stage (T4b) tumors were significantly associated with shorter DSS than those with early-stage (T1/T2) and advanced-stage (T3/T4a) tumors (p = 0.007 and 0.03, respectively). ConclusionThe present study focused on patients with SCC of the EAC at a university hospital over a period of 20 years, especially with skull base involvement, and a T4 subclassification was proposed. Complete tumor resection in an en bloc fashion could help achieve a good survival rate even in patients with locally advanced tumors.

    DOI: 10.1055/a-1733-2585


  3. A Pediatric Case of Dermoid Cyst in the Floor of the Mouth

    Doi Kohei, Nishio Naoki, Yokoi Sayaka, Tonai Kazuya, Sone Michihiko

    Practica Oto-Rhino-Laryngologica   Vol. 115 ( 4 ) page: 277 - 282   2022

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    Language:Japanese   Publisher:The Society of Practical Otolaryngology  

    DOI: 10.5631/jibirin.115.277

    CiNii Research

  4. Safety and feasibility of fat injection therapy with adipose-derived stem cells in a rabbit hypoglossal nerve paralysis model: A pilot study

    Wada A., Nishio N., Yokoi S., Tsuzuki H., Mukoyama N., Maruo T., Hiramatsu M., Yamamoto T., Goto M., Fujimoto Y., Sone M.

    Auris Nasus Larynx   Vol. 48 ( 2 ) page: 274 - 280   2021.4

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    Language:Japanese   Publisher:Auris Nasus Larynx  

    Objective: The aim of this study is to establish a unilateral tongue atrophy model by cutting the hypoglossal nerve and to evaluate the safety and feasibility of a fat injection of adipose-derived stem cells (ADSCs) to restore swallowing function. Methods: A total of 12 rabbits were randomized to three groups; the ADSCs+fat group (n=4), the fat group (n=4) and the control group (n=4). All rabbits were treated with denervation of the left hypoglossal nerve and their conditions including body weight and food intake were checked during follow-up periods (8 weeks). At 4 weeks after the transection of the nerve, rabbits received the injection therapy into the denervated side of the tongue with 1.0mL fat tissue premixed with 0.5mL ADSCs in the ADSCs+fat group, 1.0mL fat tissue premixed with 0.5mL PBS in the fat group and 1.5mL PBS in the control group. Rabbits were euthanized 8 weeks post-treatment and resected tongues were collected, formalin-fixed and paraffin embedded. To evaluate the change of the intrinsic muscles of the tongue, muscle fibers around the treatment area was analyzed by evaluating 5 consecutive hematoxylin-eosin slides per rabbit. Results: Food intake did not decrease upon nerve denervation, and none of the rabbits displayed adverse effect such as aspiration, surgical wound dehiscence or infection. No significant body weight changes were found between the three groups at 4 and 8 weeks after nerve transection (p>0.05). In the control group, the denervated side of tongue had significantly smaller muscle fiber areas and diameters compared to the non-denervated side (p<0.05). The ADSCs+fat group demonstrated a larger area of inferior longitudinal muscle fibers compared to the control and the fat groups (582±312µm2 vs. 405±220µm2 and 413±226µm2; p<0.05). A significant thicker lesser diameter of inferior longitudinal muscle fibers was found in the ADSCs+fat group compared to the control and the fat groups (24±8µm vs. 20±6µm and 20±7µm; p<0.05). Conclusion: The rabbit tongue atrophy model was found suitable for the assessment of muscle change after nerve transection. Fat injection therapy with ADSCs demonstrated great potential to prevent the muscle atrophy after denervation and to promote the muscle regeneration around the injection area.

    DOI: 10.1016/j.anl.2020.08.003



  5. Feasibility of virtual surgical simulation in the head and neck region for soft tissue reconstruction using free flap: a comparison of preoperative and postoperative volume measurement

    Yokoi S., Nishio N., Fujimoto Y., Fujii M., Iwami K., Hayashi Y., Takanari K., Hiramatsu M., Maruo T., Mukoyama N., Tsuzuki H., Wada A., Kamei Y., Sone M.

    INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY   Vol. 50 ( 3 ) page: 316 - 322   2021.3

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    Language:Japanese   Publisher:International Journal of Oral and Maxillofacial Surgery  

    In the head and neck region, preoperative evaluation of the free flap volume is challenging. The current study validated preoperative three-dimensional (3D) virtual surgical simulation for soft tissue reconstruction by assessing flap volume and evaluated fat and muscle volume changes at follow-up in 13 head and neck cancer patients undergoing anterolateral craniofacial resection. Patients received 3D virtual surgical simulation, and the volume of the planned defects was estimated by surgical simulation. Following en bloc resection of the tumor, the defect in the skull base was covered using a rectus abdominis myocutaneous flap. Following surgery, computed tomography scans were acquired at day 1 and at 6 and 12 months. Virtual planned defect was on average 227 ml (range, 154–315) and was 10% smaller than the actual flap volume in patients without skin involvement of the tumor. Between day 1 and 12 months post-surgery, the volume of fat and muscle tissue in the free flap dropped by 9% and 58%, respectively. Our results indicate that 3D virtual surgical simulation provides essential information in determining the accurate volume of the required free flap for surgical defect repair and may thus help improve surgical planning and functional and esthetic outcome.

    DOI: 10.1016/j.ijom.2020.07.025

    Web of Science


  6. Investigation of parotid gland cancer surgery that preserved the facial nerve

    Hamabata Ryoki, Mukoyama Nobuaki, Nishio Naoki, Maruo Takashi, Hiramatsu Mariko, Yokoi Sayaka, Sone Michihiko, Fujimoto Yasushi

    Toukeibu Gan   Vol. 47 ( 3 ) page: 316 - 321   2021

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    Language:Japanese   Publisher:Japan Society for Head and Neck Cancer  

    There are few reports on the transition and prognosis of postoperative facial nerve paralysis in patients undergoing parotid gland cancer surgery that preserves the facial nerve. The treatment policy for parotid gland cancer in our department is, in principle, combined resection of the facial nerve and one-stage reconstruction of the nerve if there is facial nerve paralysis before surgery, and preservation of the nerve if there is no paralysis regardless of histological type. We examined 31 cases of parotid gland cancer surgery that preserved the facial nerve over the past 15 years. The median observation period was 60 months. Total resection was performed in 24 cases, and lobectomy was performed in 7 cases. The average score of postoperative facial nerve paralysis was 24 points, and the median score was 27 points. The transition of postoperative facial nerve paralysis, although there were cases of transient complete paralysis, eventually recovered to an average of 39.5 points. The recovery period was 6 months after surgery in many cases. The treatment results were good, with 5-year overall survival rate, 5-year disease-free survival rate, and local control rate of 96.0%, 89.5%, and 93.5%, respectively. In cases of parotid gland cancer without facial nerve paralysis, treatment results are considered to be guaranteed even if the nerve is preserved regardless of the pathological type.

    DOI: 10.5981/jjhnc.47.316


    CiNii Research

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Presentations 1

  1. 筋萎縮性側索硬化症に対する誤嚥防止手術の安全性と有効性


    嚥下医学会  2022.2.24 

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    Event date: 2022.2