Updated on 2024/09/30

写真a

 
TACHIBANA Masako
 
Organization
Nagoya University Hospital Psychiatry Assistant Professor
Graduate School
Graduate School of Medicine
Title
Assistant Professor

Degree 1

  1. 医学博士 ( 2021.5   名古屋大学 ) 

Professional Memberships 1

  1. 日本精神神経学会

 

Papers 12

  1. Extremely Low Frequency, Extremely Low Magnetic Environment for depression: An open-label trial Reviewed

    Tachibana, M; Inada, T; Kimura, H; Ito, M; Kuwatsuka, Y; Kinoshita, F; Mori, D; Ohno, K

    ASIAN JOURNAL OF PSYCHIATRY   Vol. 96   page: 104036   2024.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Asian Journal of Psychiatry  

    Mitochondrial dysfunction has been suggested to play a role in depression pathogenesis. This clinical trial (jRCTs042220011) was conducted to evaluate whether depression symptoms could be alleviated by an Extremely Low Frequency, Extremely Low Magnetic Environment (ELF-ELME), which has been found in basic research studies to enhance mitochondrial membrane potential. Participants were exposed to the ELF-ELME via a head-mounted magnetic field device (10 μTesla, 4 ms, 1–8 Hz/8 s) worn for 2 h per day for 8 consecutive weeks. Four male patients with treatment-resistant depression were enrolled. Significant reductions from baseline in the average total Montgomery–Åsberg Depression Rating Scale (MADRS) score were observed at 4, 6, and 8 weeks. ELF-ELME appears to ameliorate depressive symptoms in patients with major depressive disorder safely and effectively, suggesting that it could be used as an alternative treatment for depressive patients who do not prefer to take antidepressants and in combination with antidepressant therapy for patients who only partially respond to pharmacotherapy.

    DOI: 10.1016/j.ajp.2024.104036

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  2. Machine learning algorithm-based estimation model for the severity of depression assessed using Montgomery-Asberg depression rating scale Reviewed

    Shimamoto, M; Ishizuka, K; Ohtani, K; Inada, T; Yamamoto, M; Tachibana, M; Kimura, H; Sakai, Y; Kobayashi, K; Ozaki, N; Ikeda, M

    NEUROPSYCHOPHARMACOLOGY REPORTS   Vol. 44 ( 1 ) page: 115 - 120   2024.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Neuropsychopharmacology Reports  

    Aim: Depressive disorder is often evaluated using established rating scales. However, consistent data collection with these scales requires trained professionals. In the present study, the “rater & estimation-system” reliability was assessed between consensus evaluation by trained psychiatrists and the estimation by 2 models of the AI-MADRS (Montgomery-Asberg Depression Rating Scale) estimation system, a machine learning algorithm-based model developed to assess the severity of depression. Methods: During interviews with trained psychiatrists and the AI-MADRS estimation system, patients responded orally to machine-generated voice prompts from the AI-MADRS structured interview questions. The severity scores estimated from two models of the AI-MADRS estimation system, the max estimation model and the average estimation model, were compared with those by trained psychiatrists. Results: A total of 51 evaluation interviews conducted on 30 patients were analyzed. Pearson's correlation coefficient with the scores evaluated by trained psychiatrists was 0.76 (95% confidence interval 0.62–0.86) for the max estimation model, and 0.86 (0.76–0.92) for the average estimation model. The ANOVA ICC rater & estimation-system reliability with the evaluation scores by trained psychiatrists was 0.51 (−0.09 to 0.79) for the max estimation model, and 0.75 (0.55–0.86) for the average estimation model. Conclusion: The average estimation model of AI-MADRS demonstrated substantially acceptable rater & estimation-system reliability with trained psychiatrists. Accumulating a broader training dataset and the refinement of AI-MADRS interviews are expected to improve the performance of AI-MADRS. Our findings suggest that AI technologies can significantly modernize and potentially revolutionize the realm of depression assessments.

    DOI: 10.1002/npr2.12404

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  3. Poor prognostic impact of delirium: especially on mortality and institutionalisation Reviewed

    Tachibana Masako, Inada Toshiya

    PSYCHOGERIATRICS   Vol. 23 ( 1 ) page: 187 - 195   2023.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Psychogeriatrics  

    The course of delirium is associated with increased hospital costs, healthcare complications, increased mortality, and long-term poor outcomes. Despite delirium being long recognised as one of the most important prognostic components of patients with illnesses, delirium remains poorly understood, effective management options are limited, and no effective treatment has yet been established. This review evaluated the effects of delirium on mortality, institutionalisation, and dementia in various situations to clarify its prognostic seriousness to elucidate important areas for clinical practice and future research. The effect of delirium on mortality in COVID-19 patients was similar to that in other diseases. The effect of delirium on mortality in patients with delirium between the ages of 18 and 65 may be higher than in those with delirium aged over 65, but studies are scarce. Promoting recognition of delirium at all ages is needed. With careful attention to the specific factors in younger patients that contribute to delirium, healthcare providers may be able to decrease the poor impact of delirium on clinical outcomes. Evaluation of the association between interventions for delirium such as sedation in present clinical practice and the prognosis of delirium is lacking, and further clinical studies are essential.

    DOI: 10.1111/psyg.12914

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  4. Prevalence, clinical features, and risk factors of delusions in patients with delirium. Reviewed International journal

    Masako Tachibana, Toshiya Inada, Masaru Ichida, Norio Ozaki

    International journal of geriatric psychiatry   Vol. 37 ( 6 )   2022.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: Delirium may be divided into multiple subtypes with different pathological factors. This study aimed to focus on the delirium subtype in which delusions are conspicuous and explore its prevalence, clinical characteristics, and risk factors. METHODS: The subjects were 601 delirium cases referred to the department of psychiatry over 5 years at a general hospital. The Delirium Rating Scale-Revised-98 was used to assess the delusions in patients with delirium, and the features of delusions (delusional form, object, and content) were examined. Multiple regression analysis was applied to determine whether individual factors were associated with the delusions. RESULTS: A total of 78 patients with delirium experienced delusions (13.0%). Most were classified as delusion of reference, such as persecution or poisoning, and 84.3% of patients believed that the persecutors were medical staff members. Older age (p < 0.001), female gender (p < 0.001), and living alone (p < 0.001) were significantly associated with delusions in patients with delirium. CONCLUSIONS: The content of delusions was rooted in the distress caused by the patients' medical situation, and the features and risk factors of the delusions suggested a formal similarity with late paraphrenia and "lack-of-contact paranoia." Psychological interventions that consider the isolation, anxiety, and fear behind delusions may be necessary in the care and treatment of these patients.

    DOI: 10.1002/gps.5763

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  5. Catatonia and Delirium: Similarity and Overlap of Acute Brain Dysfunction. Invited Reviewed International journal

    Masako Tachibana, Kanako Ishizuka, Toshiya Inada

    Frontiers in psychiatry   Vol. 13   page: 876727 - 876727   2022

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fpsyt.2022.876727

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  6. Possible Commonalities of Clinical Manifestations Between Dystonia and Catatonia. Invited Reviewed International journal

    Kanako Ishizuka, Masako Tachibana, Toshiya Inada

    Frontiers in psychiatry   Vol. 13   page: 876678 - 876678   2022

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fpsyt.2022.876678

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  7. Risk factors for inducing violence in patients with delirium. Reviewed International journal

    Masako Tachibana, Toshiya Inada, Masaru Ichida, Norio Ozaki

    Brain and behavior   Vol. 11 ( 8 ) page: e2276   2021.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Violence in patients with delirium may occur suddenly and unpredictably in a fluctuating state of consciousness. Although various factors are involved, appropriate assessment and early response to factors related to violence in delirium are expected to prevent dangerous and distressing acts of violence against patients, their families and medical staff, and minimize the use of physical restraint and excessive drug sedation. METHODS: Subjects were 601 delirium cases referred to the department of psychiatry over the course of 5 years at a general hospital. The demographic, clinical, and pharmacological variables of patients with violence (n = 189) were compared with those of patients without violence (n = 412). Logistic regression analysis was applied to determine whether any specific individual factors were associated with violence. RESULTS: Current smoker status (p < .0005), older age (p < .0005), male gender (p = .004), and use of intensive care units (p = .043) were identified as factors associated with violence in patients with delirium. CONCLUSIONS: Screening tools for violence in patients with delirium and adequate management may assist in better outcomes for patients and medical staff. Further research should evaluate the usefulness of nicotine replacement treatment for the prevention of violence during nicotine withdrawal, including whether it is safe for elderly inpatients with a high incidence of delirium in clinical practice.

    DOI: 10.1002/brb3.2276

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  8. Factors affecting hallucinations in patients with delirium. Reviewed International journal

    Masako Tachibana, Toshiya Inada, Masaru Ichida, Norio Ozaki

    Scientific reports   Vol. 11 ( 1 ) page: 13005 - 13005   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    Delirium develops through a multifactorial process and include multiple subtypes with different pathological factors. To refine the treatment and care for delirium, a more detailed examination of these subtypes is needed. Therefore, this study aimed to explore the factors affecting delirium in cases in which hallucinations are conspicuous. In total, 602 delirium cases referred to the psychiatry department at a general hospital between May 2015 and August 2020 were enrolled. The Delirium Rating Scale-revised-98 was used to assess perceptual disturbances and hallucinations in patients with delirium. Multiple regression analysis was applied to determine whether individual factors were associated with the hallucinations. A total of 156 patients with delirium (25.9%) experienced hallucinations, with visual hallucinations being the most common subtype. Alcohol drinking (p < 0.0005), benzodiazepine withdrawal (p = 0.004), and the use of angiotensin II receptor blockers (p = 0.007) or dopamine receptor agonists (p = 0.014) were found to be significantly associated with hallucinations in patients with delirium. The four factors detected in this study could all be reversible contributing factors derived from the use of or withdrawal from exogenous substances.

    DOI: 10.1038/s41598-021-92578-1

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  9. Factors associated with the severity of delirium Reviewed International journal

    Masako Tachibana, Toshiya Inada, Masaru Ichida, Shihori Kojima, Mayumi Shioya, Kazuki Wakayama, Norio Ozaki

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL   Vol. 36 ( 5 ) page: e2787   2021.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Background Various factors affecting the development of delirium have been identified. However, the associations between the severity of delirium and potentially related factors have not been adequately investigated. The aim of the present study was to explore factors associated with the severity of delirium and to identify the reversible contributing factors.Methods A total of 577 patients with delirium referred to the Department of Psychiatry during the 5 years from May 2015 to April 2020 at a general hospital were included. The Delirium Rating Scale-revised-98 (DRS-R-98) was used to measure the severity of delirium. Multiple regression analysis was used to determine whether individual factors were associated with the severity of delirium.Results Intensive care unit admission (p = 0.003), use of benzodiazepines (p = 0.01), dementia (p = 0.02), and older age (p = 0.045) were all positively associated the severity of delirium, while use of beta-blockers (p = 0.001) was negatively associated with the severity of delirium.Conclusions Reversible contributing factors, that is use of benzodiazepines, should be avoided as much as possible, especially in elderly patients or patients with dementia or patients who need critical care in ICU. Reducing the dose of benzodiazepines or switching them to other drugs should be a priority.

    DOI: 10.1002/hup.2787

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  10. Significant decrease in delirium referrals after changing hypnotic from benzodiazepine to suvorexant Reviewed International journal

    Masako Tachibana, Toshiya Inada, Masaru Ichida, Shihori Kojima, Takafumi Arai, Keiko Naito, Norio Ozaki

    PSYCHOGERIATRICS   Vol. 21 ( 3 ) page: 324 - 332   2021.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Background The use of benzodiazepines (BZDs) causes delirium, especially in elderly people. For this reason, suvorexant has been recommended as the first-line hypnotic in elderly patients. The aim of this study was to determine whether the first-line use of suvorexant, instead of BZDs, decreases referrals for delirium in elderly patients.Methods Since May 2016 at Nagoya Ekisaikai Hospital, suvorexant has been recommended as the first-line hypnotic instead of BZDs. In May 2017, suvorexant was adopted as the first-line hypnotic. The number of delirium cases referred to psychiatry was compared among three consecutive periods: period A (May 2015-April 2016), during which BZDs were mainly used for insomnia; period B (May 2016-April 2017), during which the use of suvorexant was recommended instead of BZDs; and period C (May 2017-April 2018), during which suvorexant was principally adopted as the first-line hypnotic for insomnia. Potential confounding factors that may affect the development of delirium were also examined during the three periods.Results The number of delirium referral cases in elderly patients in each period decreased, from 133 in period A to 86 in period B and 53 in period C. The rate of delirium referral cases decreased significantly every year (P = 9.02 x 10(-10)). Almost no significant confounding factors other than hypnotics were detected during the three periods.Conclusion The referrals for delirium in elderly patients decreased significantly after the hypnotic was changed from BZDs to suvorexant.

    DOI: 10.1111/psyg.12672

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  11. Oral medicine psychiatric liaison clinic: study of 1202 patients attending over an 18-year period Invited Reviewed

    Umemura E., Tokura T., Ito M., Kobayashi Y., Tachibana M., Miyauchi T., Tonoike T., Nagashima W., Kimura H., Arao M., Sato (Boku) A., Ozaki N., Kurita K.

    INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY   Vol. 48 ( 5 ) page: 644 - 650   2019.5

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    Authorship:Lead author, Last author, Corresponding author   Language:English   Publisher:International Journal of Oral and Maxillofacial Surgery  

    Patients with orofacial pain and discomfort often suffer from psychiatric disorders. However, few studies involving a large sample have examined the diagnostic results of patients with orofacial pain or discomfort in relation to psychiatric disorders. The purpose of this study was to summarize and clarify the characteristics and demographic data of 1202 patients attending the psychiatric liaison clinic at Aichi Gakuin University Hospital. Psychiatric diagnosis was performed by psychiatrists for all patients, based on the Diagnostic and Statistical Manual of Mental Disorders, fifth edition. Among the 1202 patients, 992 (82.5%) were female. The average age of the patients was 57.2 ± 15.0 years. The predominant broad categories of orofacial pain and discomfort seen were burning mouth syndrome (n = 484, 40.3%), persistent idiopathic facial pain (n = 258, 21.5%), and oral dysesthesia (n = 215, 17.9%). The predominant broad categories of psychiatric diagnoses seen were somatic symptoms and related disorders (n = 934, 77.7%) and depressive disorders (n = 76, 6.3%). Among the 934 patients with somatic symptoms and related disorders, 678 had a somatic symptom disorder with predominant pain. The results confirmed that most patients with orofacial pain and discomfort were middle-aged and elderly women suffering from a somatic symptom disorder with predominant pain.

    DOI: 10.1016/j.ijom.2018.12.005

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  12. Five Patients With Burning Mouth Syndrome in Whom an Antidepressant (Serotonin-Noradrenaline Reuptake Inhibitor) Was Not Effective, but Pregabalin Markedly Relieved Pain Invited Reviewed

    Mikiko Ito, Tatsuya Tokura, Keizo Yoshida, Wataru Nagashima, Hiroyuki Kimura, Eri Umemura, Masako Tachibana, Tomoya Miyauchi, Yuka Kobayashi, Munetaka Arao, Norio Ozaki, Kenichi Kurita

    CLINICAL NEUROPHARMACOLOGY   Vol. 38 ( 4 ) page: 158 - 161   2015.7

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    Burning mouth syndrome (BMS) causes idiopathic pain or a burning sensation in clinically normal oral mucosa. Burning mouth syndrome is a chronic disease with an unknown etiology. Burning mouth syndrome is also idiopathic, and a consensus regarding diagnosis/treatment has not been reached yet. Recent studies have supported the suggestion that BMS is a neuropathic pain disorder in which both the peripheral and central nervous systems are involved. Tricyclic antidepressants (nortriptyline and amitriptyline), serotonin-noradrenaline reuptake inhibitors (SNRIs) (duloxetine and milnacipran), and antiepileptic drugs, potential-dependent calcium channel (2) subunit ligands (gabapentine and pregabalin), are currently recommended as the first-choice drugs for neuropathic pain. In this study, we report 5 patients with BMS in whom there was no response to SNRI (milnacipran or duloxetine), or administration was discontinued because of adverse reactions, but in whom pregabalin therapy markedly reduced or led to the disappearance of pain in a short period. Pregabalin, whose mechanism of action differs from that of SNRIs, may become a treatment option for BMS patients who are not responsive to or are resistant to SNRIs.

    DOI: 10.1097/WNF.0000000000000093

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Books 2

  1. DSM-5-TR 精神疾患の診断・統計マニュアル

    日本精神神経学会(監修)( Role: Joint translator)

    医学書院  2023.9 

  2. 身体的苦痛症群解離症群心身症食行動症または摂食症群 = Disorders of bodily distress or bodily experience dissociative disorders psychosomatic diseases feeding or eating disorders

    大饗広之,立花昌子( Role: Joint author ,  離人感・現実感喪失症)

    中山書店  2021.7  ( ISBN:9784521748245

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    Total pages:xiii, 436p   Language:Japanese

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MISC 10

  1. うつ病におけるミトコンドリア機能異常(解説) Invited

    寺西正樹、立花昌子、伊藤美佳子、大野欽司、稲田俊也

    臨床精神薬理   Vol. 27 ( 7 ) page: 663 - 672   2024.7

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  2. 精神疾患を伴う妊産婦の支援-名古屋大学における実践でみえてきた課題 Invited

    立花昌子、後藤紋香、小谷友美

    臨床精神医学   Vol. 53 ( 5 ) page: 651 - 657   2024.5

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    Authorship:Lead author   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  3. 【現代の解離症とその治療】自閉スペクトラム症における「人格の多元化」

    大饗 広之, 立花 昌子

    精神療法   Vol. 47 ( 1 ) page: 33 - 39   2021.2

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    Language:Japanese   Publisher:(株)金剛出版  

  4. 睡眠薬としてのスボレキサント導入前後におけるせん妄コンサルテーション件数の推移

    立花 昌子, 稲田 俊也, 市田 勝, 兒嶋 しほり, 新井 孝文, 内藤 桂子, 尾崎 紀夫

    精神神経学雑誌   ( 2019特別号 ) page: S621 - S621   2019.6

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

  5. 【双極性障害薬物療法のState of the Art II】双極性障害と境界性パーソナリティ 曖昧な境界の中での治療方略

    立花 昌子

    精神科治療学   Vol. 32 ( 10 ) page: 1285 - 1291   2017.10

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    Language:Japanese   Publisher:(株)星和書店  

    昨今、うつ病の典型例が減少し非定型化が進むとともに、うつ病と双極II型障害、そしてパーソナリティ障害とのあいだの境界がわかりにくくなっている。例えば、双極II型障害の軽躁にみられる衝動・破壊的な側面や病状遷延化に伴うdemoralization(士気低下)と、境界性パーソナリティ障害の衝動不耐性とを見分けるのは必ずしも容易ではなくなっている。実際に、現行の診断基準に沿った診断のみでは薬剤選択に失敗し、それによりますます病状がこじれてしまうことも少なくないと思われる。この小論では、双極性障害と境界性パーソナリティ障害の鑑別が困難であった2つのケースを提示し、曖昧な境界の中で臨床家がどのように治療を方向付けていくべきかについて若干の整理を行った。両者は横断面的にはほとんど区別できないことを前提に、患者の病態を関わりの中で縦断的かつ複合的に捉えながら、薬物療法と精神療法的アプローチを柔軟に組み合わせていくことが何よりも求められる。(著者抄録)

  6. 口腔領域の疼痛性障害における抗うつ薬治療下での神経炎症関連物質の経時変化

    宮内 倫也, 徳倉 達也, 木村 宏之, 長島 渉, 立花 昌子, 小林 由佳, 伊藤 陽菜, 梅村 恵理, 伊藤 幹子, 栗田 賢一, 尾崎 紀夫

    精神神経学雑誌   ( 2017特別号 ) page: S645 - S645   2017.6

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

  7. 口腔内慢性疼痛を介したうつ病バイオマーカーの探索

    宮内 倫也, 徳倉 達也, 木村 宏之, 長島 渉, 立花 昌子, 小林 由佳, 伊藤 陽菜, 梅村 恵理, 伊藤 幹子, 栗田 賢一, 尾崎 紀夫

    日本うつ病学会総会・日本認知療法学会プログラム・抄録集   Vol. 12回・15回   page: 262 - 262   2015.7

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    Language:Japanese   Publisher:日本うつ病学会・日本認知療法・認知行動療法学会  

  8. 境界性パーソナリティ障害におけるうつ病・双極性障害の診断と治療

    立花 昌子, 木村 宏之, 尾崎 紀夫

    Depression Strategy   Vol. 4 ( 4 ) page: 10 - 12   2014.12

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    Language:Japanese   Publisher:(株)先端医学社  

  9. 口腔顔面領域における疼痛性障害に対するDuloxetineの疼痛軽減効果と血中濃度の関連について

    小林 由佳, 長島 渉, 徳倉 達也, 立花 昌子, 宮内 倫也, 梅村 恵理, 伊藤 幹子, 荒尾 宗孝, 木村 宏之, 吉田 契造, 栗田 賢一, 尾崎 紀夫

    日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集   Vol. 24回・44回   page: 158 - 158   2014.11

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    Language:Japanese   Publisher:日本臨床精神神経薬理学会・日本神経精神薬理学会  

  10. 交代人格を呈したアスペルガー障害の2症例

    立花 昌子, 田中 聡, 西岡 和郎

    臨床精神病理   Vol. 31 ( 1 ) page: 33 - 33   2010.4

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    Language:Japanese   Publisher:日本精神病理学会  

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Presentations 2

  1. 機能性ディスペプシアを発症し回避・制限性食物摂取症と診断された一例

    永井里奈、立花昌子、池田匡志

    第182回東海精神神経学会  2024.1.21  東海精神神経学会

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    Event date: 2024.1

    Presentation type:Oral presentation (general)  

  2. 周産期リエゾン

    立花昌子

    日本精神分析的精神医学会  2023.8.26 

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    Event date: 2023.8

    Presentation type:Oral presentation (general)  

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. せん妄下にみられる各精神症状の要因や予後に関する研究

    Grant number:22K15747  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    立花 昌子

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    Authorship:Principal investigator 

    Grant amount:\780000 ( Direct Cost: \600000 、 Indirect Cost:\180000 )

    せん妄は認知機能悪化や入院の長期化に関わる重篤な病態であるが、その発症や遷延化に及ぼす要因は種々様々である。
    現行の診断基準における分類は活動水準にのみによるものであり、必ずしも臨床応用に即したものにはなっていない。臨床でのせん妄治療は抗精神病薬の使用に偏し、発症 要因や症状の多様性を十分に考慮に入れたものとなっていない。
    本研究では総合病院で発症・重症化し、精神科対応を求められた重篤なせん妄症例を対象として、特定の精神症状(幻覚、妄想、暴力等)に基づいて、その発症要因、臨床経過、予後を検討し、それぞれのタイプのせん妄の発症・重篤化・遷延を防止するために必要な分化した対応のあり方を検討する。

 

Teaching Experience (On-campus) 3

  1. PBLチュートリアル

    2023

  2. PBLチュートリアル

    2022

  3. PBLチュートリアル

    2021

Teaching Experience (Off-campus) 1

  1. 精神看護学方法論Ⅰ

    2015.4