2022/01/04 更新

写真a

スナガワ マサキ
砂川 真輝
SUNAGAWA Masaki
所属
大学院医学系研究科 外科周術期管理学(ヤクルト) 特任助教
職名
特任助教
連絡先
メールアドレス

学位 2

  1. 博士(医学) ( 2017年3月   名古屋大学 ) 

  2. 学士(医学) ( 2005年3月   島根大学 ) 

研究キーワード 5

  1. Retroperitoneal sarcoma

  2. Pancreatic cancer

  3. Translational research

  4. Surgical Oncology

  5. Metabolomics

研究分野 4

  1. ライフサイエンス / 消化器外科学

  2. ライフサイエンス / 腫瘍診断、治療学

  3. ライフサイエンス / 実験動物学

  4. ライフサイエンス / 生体材料学

現在の研究課題とSDGs 2

  1. 希少癌早期発見パネルの開発

  2. アシドーシス環境下における癌悪性化機構の解明と新規治療方針の開発

経歴 2

  1. 名古屋大学医学部医学系研究科   外科周術管理学講座   特任助教

    2021年4月 - 現在

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    国名:日本国

  2. Columbia University Irving cancer research center   Division of digestive disease

    2017年5月 - 2020年3月

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    国名:アメリカ合衆国

学歴 2

  1. 名古屋大学   医学部   医学系研究科

    2013年4月 - 2017年3月

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    国名: 日本国

    備考: 博士課程

  2. 島根大学   医学部   医学科

    1999年4月 - 2005年3月

所属学協会 14

  1. 日本臨床外科学会

  2. 日本外科学会

  3. 日本消化器外科学会

  4. 日本癌学会

  5. 日本消化器外科学会   専門医・指導医

    2012年4月 - 現在

  6. 日本外科学会   専門医

    2005年4月 - 現在

  7. American Pancreatic Association

  8. 日本サルコーマ治療研究学会

  9. 日本内視鏡外科学会

  10. 日本癌治療学会

  11. 日本肝胆膵外科学会

  12. 日本胆道学会

  13. 日本膵臓学会

  14. 日本臨床腫瘍学会

▼全件表示

受賞 1

  1. 47th Young Investigator awards

    2016年10月   47th American Pancreatic Association   TFF1 might inhibit invasion but accelerate lymph node metastasis of pancreatic ductal adenocarcinoma

 

論文 7

  1. Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells 国際誌

    Dobrokhotov Oleg, Sunagawa Masaki, Torii Takeru, Mii Shinji, Kawauchi Keiko, Enomoto Atsushi, Sokabe Masahiro, Hirata Hiroaki

    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY   9 巻   頁: 728383 - 728383   2021年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Frontiers in Cell and Developmental Biology  

    Actomyosin contractility regulates various cellular processes including proliferation and differentiation while dysregulation of actomyosin activity contributes to cancer development and progression. Previously, we have reported that actomyosin-generated tension at adherens junctions is required for cell density-dependent inhibition of proliferation of normal skin keratinocytes. However, it remains unclear how actomyosin contractility affects the hyperproliferation ability of cutaneous squamous cell carcinoma (cSCC) cells. In this study, we find that actomyosin activity is impaired in cSCC cells both in vitro and in vivo. External application of tensile loads to adherens junctions by sustained mechanical stretch attenuates the proliferation of cSCC cells, which depends on intact adherens junctions. Forced activation of actomyosin of cSCC cells also inhibits their proliferation in a cell-cell contact-dependent manner. Furthermore, the cell cycle arrest induced by tensile loading to adherens junctions is accompanied by epidermal differentiation in cSCC cells. Our results show that the degree of malignant properties of cSCC cells can be reduced by applying tensile loads to adherens junctions, which implies that the mechanical status of adherens junctions may serve as a novel therapeutic target for cSCC.

    DOI: 10.3389/fcell.2021.728383

    Web of Science

    Scopus

    PubMed

  2. Interleukin-1β-induced pancreatitis promotes pancreatic ductal adenocarcinoma via B lymphocyte-mediated immune suppression. 国際誌

    Takahashi R, Macchini M, Sunagawa M, Jiang Z, Tanaka T, Valenti G, Renz BW, White RA, Hayakawa Y, Westphalen CB, Tailor Y, Iuga AC, Gonda TA, Genkinger J, Olive KP, Wang TC

    Gut   70 巻 ( 2 ) 頁: 330 - 341   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/gutjnl-2019-319912

    PubMed

  3. Is constant negative pressure for external drainage of the main pancreatic duct useful in preventing pancreatic fistula following pancreatoduodenectomy? 国際誌

    Sunagawa Masaki, Yokoyama Yukihiro, Yamaguchi Junpei, Ebata Tomoki, Sugawara Gen, Igami Tsuyoshi, Mizuno Takashi, Nagino Masato

    PANCREATOLOGY   19 巻 ( 4 ) 頁: 602 - 607   2019年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Pancreatology  

    Background: This study sought to investigate the utility of constant negative pressure for external drainage of the main pancreatic duct in preventing postoperative pancreatic fistula (POPF) after pancreatoduodenectomy. Methods: Only patients with soft pancreas were included. In the former period (July 2013 to May 2015), gravity dependent drainage was applied (gravity dependent drainage group), and in the latter period (June 2015 to November 2016), constant negative pressure drainage (negative pressure drainage group) was applied to the main pancreatic duct stent. Results: There were 37 patients in the gravity dependent drainage group and 39 patients in the negative pressure drainage group. Clinically relevant POPF occurred in 21 patients (56.8%) in the gravity dependent drainage group and 13 patients (33.3%) in the negative pressure drainage group (p = 0.040). The incidence rate of major complications (Clavien-Dindo grade > III) was significantly lower in the negative pressure drainage group (13.2%) compared to the gravity dependent drainage group (48.7%) (p = 0.001). In-hospital stay was also significantly shorter in the negative pressure drainage group compared to the gravity dependent drainage group (median 25 vs. 33 days, p = 0.024). Multivariate analysis demonstrated that the gravity dependent drainage was one of the independent risk factors for the incidence of POPF (odds ratio, 3.33; p = 0.032). Conclusions: In patients with soft pancreas, the incidence rate of clinically relevant POPF may be reduced by applying constant negative pressure to the pancreatic duct stent. It also has a potential to reduce overall incidence of major complications and shorten in-hospital stay after pancreatoduodenectomy.

    DOI: 10.1016/j.pan.2019.04.002

    Web of Science

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    PubMed

  4. Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness. 国際誌

    Renz BW, Tanaka T, Sunagawa M, Takahashi R, Jiang Z, Macchini M, Dantes Z, Valenti G, White RA, Middelhoff MA, Ilmer M, Oberstein PE, Angele MK, Deng H, Hayakawa Y, Westphalen CB, Werner J, Remotti H, Reichert M, Tailor YH, Nagar K, Friedman RA, Iuga AC, Olive KP, Wang TC

    Cancer discovery   8 巻 ( 11 ) 頁: 1458 - 1473   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1158/2159-8290.CD-18-0046

    PubMed

  5. Trefoil factor family 1 expression in the invasion front is a poor prognostic factor associated with lymph node metastasis in pancreatic cancer

    Sunagawa Masaki, Yamaguchi Junpei, Kokuryo Toshio, Ebata Tomoki, Yokoyama Yukihiro, Sugawara Gen, Nagino Masato

    PANCREATOLOGY   17 巻 ( 5 ) 頁: 782 - 787   2017年

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    記述言語:日本語   出版者・発行元:Pancreatology  

    Objectives Trefoil Factor Family protein 1 (TFF1) is secreted from mucus-producing cells. The relationship between TFF1 expression and clinical outcome in pancreatic ductal adenocarcinoma (PDAC) remains unknown. We aimed to evaluate the prognostic significance of TFF1 expression in PDAC. Methods TFF1 expression was examined on paraffin-embedded sections from 91 patients with resected PDAC using immunohistochemistry. The relationships between TFF1 expression and clinicopathological features were analyzed. Results Among 91 PDAC patients, 71 patients (79.7%) showed TFF1 expression in cancer cells. In a subgroup of 71 patients, TFF1 expression was predominantly observed in the central part of the tumor, whereas TFF1 expression in the invasion front was reduced in 33 patients (46.4%). A significant correlation between preserved TFF1 expression in the invasion front and lymph node metastasis was observed. Univariate survival analysis revealed that preserved TFF1 expression in the invasion front, positive lymphatic invasion, lymph node metastasis and R1 resection was a significant poor prognostic factor in TFF1-positive PDAC patients. Conclusions TFF1 expression is frequently lost or decreased in the invasion front of human PDAC, and preserved TFF1 expression in the invasion front might predict poor survival in patients with PDAC.

    DOI: 10.1016/j.pan.2017.07.188

    Web of Science

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  6. Suppression of skin tumorigenesis in CD109-deficient mice 国際誌

    Sunagawa Masaki, Mii Shinji, Enomoto Atsushi, Kato Takuya, Murakumo Yoshiki, Shiraki Yukihiro, Asai Naoya, Asai Masato, Nagino Masato, Takahashi Masahide

    ONCOTARGET   7 巻 ( 50 ) 頁: 82836 - 82850   2016年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oncotarget  

    CD109 is a glycosylphosphatidylinositol-anchored glycoprotein that is highly expressed in several types of human cancers, particularly squamous cell carcinomas. We previously reported that CD109-deficient mice exhibit epidermal hyperplasia and chronic skin inflammation. Although we found that CD109 regulates differentiation of keratinocytes in vivo, the function of CD109 in tumorigenesis remains unknown. In this study, we investigated the role of CD109 in skin tumorigenesis using a twostage carcinogenesis model in CD109-deficient mice with chronic skin inflammation. Immunohistochemical analysis revealed a higher level of TGF-β protein expression in the dermis of CD109-deficient mice than in that of wild-type mice. Additionally, immunofluorescence analysis showed that Smad2 phosphorylation and Nrf2 expression were enhanced in primary keratinocytes from CD109-deficient mice compared with in those from wild-type mice. Although no significant difference was found in conversion rates from papilloma to carcinoma between wild-type and CD109- deficient mice in the carcinogenesis model, we observed fewer and smaller papillomas in CD109-deficient mice than in wild-type mice. Apoptosis and DNA damage marker levels were significantly reduced in CD109-deficient skin compared with in wildtype skin at 24 h after 7, 12-dimethylbenz (α) anthracene treatment. Furthermore, mutation-specific PCR revealed that the mutation frequency of the H-ras gene was less in CD109-deficient skin than in wild-type skin in this model. These results suggest that CD109 deficiency suppresses skin tumorigenesis by enhancing TGF-β/Smad/Nrf2 pathway activity and decreasing the mutation frequency of the H-ras gene.

    DOI: 10.18632/oncotarget.12653

    Web of Science

    Scopus

    PubMed

  7. TFF1 Might Inhibit Invasion but Accelerate Lymph Node Metastasis of Pancreatic Ductal Adenocarcinoma

    Sunagawa M., Yamaguchi J., Yokoyama Y., Kokuryo T., Nagino M.

    PANCREAS   45 巻 ( 10 ) 頁: 1540 - 1540   2016年11月

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    記述言語:日本語  

    Web of Science

▼全件表示

講演・口頭発表等 1

  1. 後腹膜肉腫初回手術後再発症例の治療選択

    砂川真輝, 横山幸浩, 伊神剛, 水野隆史, 山口淳平, 尾上俊介, 渡辺伸元, 江畑智希

    第59回日本がん治療学会学術集会  2021年10月23日 

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    開催年月日: 2021年10月

    記述言語:日本語   会議種別:ポスター発表  

科研費 1

  1. 弱酸性腫瘍間質液のpH制御による抗癌剤治療効果の検討

    研究課題/研究課題番号:21K20800  2021年8月 - 2023年3月

    日本学術振興会  科学研究費助成事業 研究活動スタート支援  研究活動スタート支援

    砂川 真輝

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    担当区分:研究代表者 

    配分額:3120000円 ( 直接経費:2400000円 、 間接経費:720000円 )