Updated on 2022/04/12


AKAI Nanami
Graduate School of Science Designated assistant professor
Designated assistant professor

Degree 1

  1. 博士(医学) ( 2018.3   神戸大学 ) 


Papers 2

  1. Epithelial cell-turnover ensures robust coordination of tissue growth in Drosophila ribosomal protein mutants Reviewed

    Akai Nanami, Ohsawa Shizue, Sando Yukari, Igaki Tatsushi

    PLOS GENETICS   Vol. 17 ( 1 ) page: e1009300   2021.1

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:PLoS Genetics  

    Highly reproducible tissue development is achieved by robust, time-dependent coordination of cell proliferation and cell death. To study the mechanisms underlying robust tissue growth, we analyzed the developmental process of wing imaginal discs in Drosophila Minute mutants, a series of heterozygous mutants for a ribosomal protein gene. Minute animals show significant developmental delay during the larval period but develop into essentially normal flies, suggesting there exists a mechanism ensuring robust tissue growth during abnormally prolonged developmental time. Surprisingly, we found that both cell death and compensatory cell proliferation were dramatically increased in developing wing pouches of Minute animals. Blocking the cell-turnover by inhibiting cell death resulted in morphological defects, indicating the essential role of cell-turnover in Minute wing morphogenesis. Our analyses showed that Minute wing discs elevate Wg expression and JNK-mediated Dilp8 expression that causes developmental delay, both of which are necessary for the induction of cell-turnover. Furthermore, forced increase in Wg expression together with developmental delay caused by ecdysone depletion induced cell-turnover in the wing pouches of non- Minute animals. Our findings suggest a novel paradigm for robust coordination of tissue growth by cell-turnover, which is induced when developmental time axis is distorted.

    DOI: 10.1371/journal.pgen.1009300

    Web of Science



  2. Wingless signaling regulates winner/loser status in Minute cell competition Reviewed

    Akai Nanami, Igaki Tatsushi, Ohsawa Shizue

    Genes to Cells   Vol. 23 ( 3 ) page: 234 - 240   2018.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12568