Updated on 2022/03/17


Nagoya University Hospital Gastroenterology Assistant professor of hospital
Assistant professor of hospital

Degree 1

  1. 博士(医学) ( 2020.3   名古屋大学 ) 

Research Interests 3

  1. NAFLD

  2. 門脈圧亢進症

  3. 肝疾患

Research Areas 1

  1. Life Science / Gastroenterology

Current Research Project and SDGs 1

  1. 肝硬変の合併症に関する研究

Education 2

  1. Nagoya University

    2016.4 - 2020.3

  2. Hokkaido University

    2002.4 - 2008.3

Professional Memberships 6

  1. 日本内科学会   総合内科専門医 認定医

  2. 日本消化器病学会   専門医

  3. 日本肝臓学会   専門医

  4. 日本消化器内視鏡学会   専門医

  5. 日本門脈圧亢進症学会

  6. 日本小児外科学会

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Papers 11

  1. Changes in Body Composition Predict the Time to Treatment Failure of Lenvatinib in Patients with Advanced Hepatocellular Carcinoma: A Pilot Retrospective Study.

    Yamamoto T, Imai N, Kuzuya T, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M

    Nutrition and cancer     page: 1 - 10   2022.3

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    DOI: 10.1080/01635581.2022.2049322


  2. Absence of large portal collateral vessels is associated with spontaneous improvement of cirrhotic portal vein thrombosis

    Yokoyama Shinya, Ishizu Yoji, Honda Takashi, Imai Norihiro, Ito Takanori, Yamamoto Kenta, Tsuzuki Tomoyuki, Ishigami Masatoshi

    HEPATOLOGY RESEARCH   Vol. 52 ( 2 ) page: 199 - 209   2022.2

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    Language:Japanese   Publisher:Hepatology Research  

    Aim: Portal vein thrombosis (PVT) is a major complication in patients with liver cirrhosis (LC). In some cases, PVT decreases spontaneously, but the factors that predict this are still not fully understood. Methods: This was a retrospective, multicenter study that included 77 consecutive patients with cirrhotic PVT. Forty-eight patients did not undergo anticoagulation and 29 patients did between the time of the first diagnosis of PVT and the follow-up radiological imaging undertaken 1–6 months later. A complete disappearance and 25% shrinkage of PVT was defined as complete remission (CR) and partial remission (PR), respectively. Portosystemic collateral vessels larger than 9 mm in diameter were defined as large collateral vessels. Results: Complete remission + PR was found in 37.5% of the anticoagulation-naïve patients. On univariate analysis, the absence of large collateral vessels, absence of PVT in the main trunk of the portal vein, a high platelet count, and a low FIB-4 index were significant factors associated with CR + PR. On multivariate analysis, the absence of large collateral vessels was the unique factor associated with CR + PR of PVT (odds ratio 5.9; 95% confidence interval, 1.73–20.1). The CR + PR rate for anticoagulated patients was 44.8%. However, no predictors for a good treatment effect of anticoagulation for PVT were identified. Conclusions: Spontaneous improvement of PVT in patients with LC can be expected when large collateral vessels are absent. For these patients, the option of observing them without anticoagulation can be considered in expectation of spontaneous reduction of PVT.

    DOI: 10.1111/hepr.13725

    Web of Science



  3. Assessing the Complicated Venous Hemodynamics and Therapeutic Outcomes of Budd-Chiari Syndrome with Respiratory-gated 4D Flow MR Imaging During the Expiratory and Inspiratory Phases

    Hyodo Ryota, Takehara Yasuo, Mizuno Takashi, Ichikawa Kazushige, Yokoyama Shinya, Ishizu Yoji, Naganawa Shinji

    Magnetic Resonance in Medical Sciences   Vol. advpub ( 0 )   2021.12

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    Language:English   Publisher:Japanese Society for Magnetic Resonance in Medicine  

    <p>A man in his 50s with Budd-Chiari syndrome diagnosed with the suprahepatic inferior vena cava (IVC) obstruction on CT was assessed using 4D Flow MRI before and after balloon angioplasty. 4D Flow MRI acquired in two respiratory phases, depicted complex hemodynamic and respiratory variability, and a jet stream at the narrowed channel of the membranous IVC. Post-interventional 4D Flow MRI showed that the IVC blood flow increased with corrected flow directions in the infrarenal IVC.</p>

    DOI: 10.2463/mrms.ici.2021-0110


    CiNii Research

  4. Safety and Efficacy of Glass Membrane Pumping Emulsification Device in Transarterial Chemoembolization for Hepatocellular Carcinoma: First Clinical Outcomes

    Imai Norihiro, Yokoyama Shinya, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishigami Masatoshi

    ANTICANCER RESEARCH   Vol. 41 ( 11 ) page: 5817 - 5820   2021.11

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    Language:Japanese   Publisher:Anticancer Research  

    Aim: Novel glass membrane pumping emulsification devices (GMDs) enable the formation of a high-percentage water-in-oil emulsion with homogeneous and stable droplets. Although GMDs are expected to improve therapeutic effects in transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC), clinical outcomes are not yet available. Patients and Methods: A total of 26 patients with unresectable HCC who underwent TACE using a GMD were analyzed retrospectively. Ethiodized oil was mixed with epirubicin solution using a GMD. The emulsion was injected into the tumor-feeding artery, followed by embolization. Results: The median size of HCCs was 28 (range=15-60) mm, and 15 nodules were solitary. Overall treatment effects were complete response in 18 cases (90%) and partial response in two (10%). The local recurrence rate at 6 months was 24.2%. No major complication was observed except for grade 4 elevations of liver enzymes in one case. Conclusion: TACE using a GMD is effective and safe in clinical practice.

    DOI: 10.21873/anticanres.15399

    Web of Science



  5. Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine

    Yamamoto Kenta, Honda Takashi, Yokoyama Shinya, Ma Lingyun, Kato Asuka, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Nakamura Masanao, Kawashima Hiroki, Ishigami Masatoshi, Tsuji Noriko M., Fujishiro Mitsuhiro

    DIGESTIVE AND LIVER DISEASE   Vol. 53 ( 11 ) page: 1443 - 1450   2021.11

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    Language:Japanese   Publisher:Digestive and Liver Disease  

    Background & aims: Hepatocellular carcinoma in nonalcoholic steatohepatitis is caused by the complex factors of inflammation, fibrosis and microbiomes. We used network analysis to examine the interrelationships of these factors. Methods: C57Bl/6 mice were categorized into groups: choline-sufficient high-fat (CSHF, n = 8), choline-deficient high-fat (CDHF, n = 9), and CDHF+ diethylnitrosamine (DEN, n = 8). All mice were fed CSHF or CDHF for 20 weeks starting at week 8, and mice in the CDHF + DEN group received one injection of DEN at 3 weeks of age. Bacterial gene was isolated from feces and analyzed using Miseq. Results: The CSHF group had less fibrosis than the other groups. Tumors were found in 22.2% and 87.5% of the CDHF group and CDHF + DEN groups, respectively. Gene expression in the liver of Cdkn1a (p21: tumor-suppressor) and c-jun was highest in the CDHF group. Bacteroides, Roseburia, Odoribacter, and Clostridium correlated with fibrosis. Streptococcus and Dorea correlated with inflammation and tumors. Akkermansia and Bilophila were inversely correlated with fibrosis and Bifidobacterium was inversely correlated with tumors. Conclusions: DEN suppressed the overexpression of p21 caused by CDHF. Some bacteria formed a relationship networking associated with their progression and inhibition for tumors and fibrosis.

    DOI: 10.1016/j.dld.2021.02.013

    Web of Science



  6. Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis

    Muto Hisanori, Ito Takanori, Tanaka Taku, Yokoyama Shinya, Yamamoto Kenta, Imai Norihiro, Ishizu Yoji, Maeda Keiko, Honda Takashi, Ishikawa Tetsuya, Kato Asuka, Ohshiro Taichi, Kano Fumiya, Yamamoto Akihito, Sakai Kiyoshi, Hibi Hideharu, Ishigami Masatoshi, Fujishiro Mitsuhiro

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 18778   2021.9

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    Language:Japanese   Publisher:Scientific Reports  

    Non-alcoholic steatohepatitis (NASH) occurrence has been increasing and is becoming a major cause of liver cirrhosis and liver cancer. However, effective treatments for NASH are still lacking. We examined the benefits of serum-free conditioned medium from stem cells derived from human exfoliated deciduous teeth (SHED-CM) on a murine non-alcoholic steatohepatitis (NASH) model induced by a combination of Western diet (WD) and repeated administration of low doses of carbon tetrachloride intraperitoneally, focusing on the gut-liver axis. We showed that repeated intravenous administration of SHED-CM significantly ameliorated histological liver fibrosis and inflammation in a murine NASH model. SHED-CM inhibited parenchymal cell apoptosis and reduced the activation of inflammatory macrophages. Gene expression of pro-inflammatory and pro-fibrotic mediators (such as Tnf-α, Tgf-β, and Ccl-2) in the liver was reduced in mice treated with SHED-CM. Furthermore, SHED-CM protected intestinal tight junctions and maintained intestinal barrier function, while suppressing gene expression of the receptor for endotoxin, Toll-like receptor 4, in the liver. SHED-CM promoted the recovery of Caco-2 monolayer dysfunction induced by IFN-γ and TNF-α in vitro. Our findings suggest that SHED-CM may inhibit NASH fibrosis via the gut-liver axis, in addition to its protective effect on hepatocytes and the induction of macrophages with unique anti-inflammatory phenotypes.

    DOI: 10.1038/s41598-021-98254-8

    Web of Science



  7. Factors associated with bleeding after endoscopic variceal ligation for children

    Shinya Yokoyama, Yoji Ishizu, Masatoshi Ishigami, Takashi Hond , Teiji Kuzuya, Takanori Ito, Akinari Hinoki, Wataru Sumida, Chiyoe Shirota, Takahisa Tainaka, Satoshi Makita, Kazuki Yokota, Hiroo Uchida, Mitsuhiro Fujishiro

    Pediatrics International     2021.1

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    Authorship:Lead author  

    DOI: 10.1111/ped.14614

  8. Successful repeated endoscopic injection sclerotherapy for severe esophagogastric varices in an infant with biliary atresia: A case report

    Yokoyama S.

    Gastroenterological Endoscopy   Vol. 62 ( 12 ) page: 3064 - 3071   2020.12

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    Publisher:Gastroenterological Endoscopy  

    DOI: 10.11280/gee.62.3064



    Yokoyama Shinya, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Shirota Chiyoe, Uchida Hiroo, Fujishiro Mitsuhiro

    HEPATOLOGY   Vol. 70   page: 200A - 200A   2019.10

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  10. Spleen stiffness by 2-D shear wave elastography is the most accurate predictor of high-risk esophagogastric varices in children with biliary atresia

    Yokoyama Shinya, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Hirooka Yoshiki, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Chiba Kosuke, Uchida Hiroo, Fujishiro Mitsuhiro

    HEPATOLOGY RESEARCH   Vol. 49 ( 10 ) page: 1162 - 1168   2019.10

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    Publisher:Hepatology Research  

    DOI: 10.1111/hepr.13381

    Web of Science


  11. Antifibrotic Effects of 1,25(OH)(2)D-3 on Nonalcoholic Steatohepatitis in Female Mice

    Ma Lingyun, Ishigami Masatoshi, Honda Takashi, Yokoyama Shinya, Yamamoto Kenta, Ishizu Yoji, Kuzuya Teiji, Hayashi Kazuhiko, Hirooka Yoshiki, Goto Hidemi

    DIGESTIVE DISEASES AND SCIENCES   Vol. 64 ( 9 ) page: 2581 - 2590   2019.9

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    Publisher:Digestive Diseases and Sciences  

    DOI: 10.1007/s10620-019-05560-3

    Web of Science


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