Updated on 2026/07/17

写真a

 
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Degree 1

  1. Degree　text （ 2003.3   Nagoya university ） 

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Research Interests 1

  1. Research　keyword

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Current Research Project and SDGs 1

  1. Title　Text

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Research History 1

  1. Chiba University   Professor

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Education 1

  1. Nagoya University   学部Text   学科Text

    2000.4 - 2004.3

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    Country： Japan

    Notes： 備考text

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Committee Memberships 1

  1. 委員会名Text   委員名Text  

    2020.4   

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    Committee type：Academic society

    特記事項　Text

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Awards 1

  1. 賞名Text

    2024.6   授与機関Text   タイトルText

    受賞者Text

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    Award type：Honored in official journal of a scientific society, scientific journal  Country：Japan

    概要Text

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Papers 5

  1. Long-term outcomes of Qing-Dai-induced pulmonary arterial hypertension. Reviewed International coauthorship International journal Open Access

    Sarasa Isobe, Ly Tu, Yoshihiro Dohi, Takahiro Hiraide, Shiro Adachi, Naohiro Komura, Ichizo Tsujino, Takumi Inami, Fusako Sera, Yasuchika Kato, Masaru Hatano, Shuichi Ueno, Takeshi Ogo, Yoshiyuki Orihara, Hiroyuki Fujii, Kuniki Amano, David Montani, Christophe Guignabert, Marc Humbert, Koichiro Tatsumi, Yuichi Tamura

    ERJ open research   Vol. 11 ( 6 )   2025.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Qing-Dai (indigo naturalis), which is used to treat inflammatory bowel disease in Japan, has been linked to pulmonary arterial hypertension (PAH) and is recognised in the 2022 European Society of Cardiology/European Respiratory Society guidelines as a drug associated with PAH. However, the long-term clinical course of Qing-Dai-induced PAH has not been studied. METHODS: This retrospective multicentre study included 20 patients diagnosed with PAH after Qing-Dai use in Japan between 2011 and 2024. Haemodynamic data were collected when PAH was diagnosed, within 1 year after Qing-Dai discontinuation and at the final follow-up evaluation. To elucidate the underlying mechanisms, we analysed the composition of Qing-Dai and examined its effects on vascular endothelial cells. RESULTS: The study cohort comprised 11 female and nine male patients (median age: 40 years; range: 19-70 years). The median duration of Qing-Dai exposure before PAH was diagnosed was 4.8 years (range: 0.5-15 years). Discontinuation of Qing-Dai and the use of PAH medications were associated with significant improvement in haemodynamic parameters. The mean pulmonary arterial pressure decreased from 52.5 to 25.0 mmHg, and the median pulmonary vascular resistance decreased from 10.8 to 2.6 Wood units. Six (30%) patients discontinued PAH medication and remained recurrence-free. One patient experienced PAH relapse after discontinuation of PAH medications. Seven (35%) patients exhibited persistent PAH despite treatment. A mass spectrometry analysis of Qing-Dai identified indirubin, which was found to induce endothelial apoptosis. CONCLUSION: Discontinuation of Qing-Dai is important to PAH management. Routine follow-up is necessary to monitor potential recurrence.

    DOI： 10.1183/23120541.00675-2025

    Open Access

    PubMed

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  2. 論文Text Invited Reviewed International coauthorship International journal Open Access

    著者Text

      Vol. 1 ( 2 ) page： 3 - 4   2025.5

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    Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1063/5.0201870

    Research data storage URL： https://www.nagoya-u.ac.jp/

  3. 手入力 testインパクトファクター　eISSNあり　掲載誌なし Invited Reviewed

        2025.5

  4. 手入力test２　インパクトファクター　掲載誌なしINNSあり Invited Reviewed

        2025.5

  5. 手入力test２　インパクトファクター　ISSNなし Invited Reviewed

    WORLD JOURNAL OF GASTROENTEROLOGY     2025.5

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Books 1

  1. タイトルText Reviewed International journal

    著者Text（ Role： Sole author ,  担当範囲Text）

    出版社・発行元Text  2024.8  （ ISBN:9783709115718 ）

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    Total pages：50   Responsible for pages：50   Language：Japanese Book type：Scholarly book

    概要Text

    DOI： 10.1063/5.0201870

    Other Link： https://profs.provost.nagoya-u.ac.jp/search?m=home&l=ja

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Presentations 1

  1. タイトルText Invited International coauthorship International conference

    講演者Text

    会議名Text  2025.1.1  主催者Text

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    Event date： 2025.1

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：開催地Text   Country：Japan  

    概要text

    DOI： 10.1063/5.0201870

    Other Link： https://www.nagoya-u.ac.jp/

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Works 1

  1. 作品名Text International coauthorship

    発表者Text

    2023.9

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    Work type：Web Service   Location：発表場所Text  

    概要Text

    DOI： 10.1063/5.0201870

    Other Link： https://profs.provost.nagoya-u.ac.jp/search?m=home&l=ja

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Other research activities 1

  1. タイトルText

    2024.1

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    内容Text

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Research Project for Joint Research, Competitive Funding, etc. 1

  1. タイトルText International coauthorship

    Grant number：22K21345  2024.9

    制度名Text  研究種目Text

    担当研究者Text

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\20000 （ Direct Cost: \10000 、 Indirect Cost：\10000 ）

    研究概要Text

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KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. タイトルText International coauthorship

    Grant number：22K21345  2024.9

    提供機関Text  制度名Text  研究種目Text

    担当研究者Text

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    Authorship：Coinvestigator(s)  Grant type：Collaborative (industry/university)

    Grant amount：\20000 （ Direct Cost: \10000 、 Indirect Cost：\10000 ）

    研究概要Text

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Industrial property rights 1

  1. 産業財産権テキスト

    発明者等Text

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    Applicant：出願人Text

    Application no：1234-12345  Date applied：2020.9

    Announcement no：1234567890  Date announced：2024.9

    Publication no：123456733  Date published：2024.10

    Patent/Registration no：123456  Date registered：2024.10  Date issued：2024.10

    Rights holder：権利者Text   Country of applicant：Domestic   Country of acquisition：Domestic

    概要Text

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Teaching Experience (On-campus) 1

  1. 科目Text

    2025

    　詳細を見る

    概要Text

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Teaching Experience (Off-campus) 1

  1. 科目text

    2025.9 （Nagoya University）

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    Level：Undergraduate (specialized)  Country：Japan

    概要Text

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Social Contribution 1

  1. タイトルText

    Role(s)：Appearance,　Commentator,　Media coverage,　Interviewer,　Lecturer,　Informant,　Organizing member,　Investigater,　Contribution

    主催者などText  番組名Text  場所テキスト  2024.9

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    Audience： College students,　Teachers,　Researchesrs,　Scientific,　Civic organization,　Media

    Type：TV or radio program

    概要Text

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Media Coverage 1

  1. タイトルtext TV or radio program

    主催者などText  番組名Text  掲載箇所Text  1980.9

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    Author：Myself 

    概要Text

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Academic Activities 1

  1. タイトルtext

    Role(s)：Planning, management, etc.,　Panel moderator, session chair, etc.,　Supervision (editorial),　Review, evaluation,　Planning/Implementing academic research,　Peer review,　Save/Restore

    主催者Text  （ 場所Text ） 2024.9

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    Type：Academic research 

    概要Text

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